Fenugreek

Name	AC	CK
Diabetes Mellitus: Type 2	15	92
Hyperlipidemia	7	48
Insulin Resistance	5	33
Breast Milk: Inadequate/Poor Quality	2	30
Hyperglycemia	5	27
Anxiety	3	21
Depression	4	15
Asthma	2	12
Diabetes Mellitus: Type 1	2	12
Dyslipidemias	2	12
Menopausal Syndrome	2	12
Polycystic Ovary Syndrome	2	11
Aging	1	10
Chronic Pain	1	10
Colic	1	10
Diabetes Mellitus: Type 2: Prevention	1	10
Fatigue: Excercise-Induced	1	10
Glycemia	1	10
Hot Flash	1	10
Lactation Disorders	1	10
Postmenopausal Disorders	1	10
Postoperative Recovery	1	10
Prediabetes	1	10
Stress	1	10
Testosterone: Too Low	1	10
Triglycerides: Elevated	1	10
Vaginal Atrophy	1	10
Alcoholic Liver Disease	5	9
Oxidative Stress	5	9
Obesity	5	8
Alcohol Toxicity	4	7
Cancers: All	3	7
Inflammation	4	7
Chemically-Induced Liver Damage	3	6
Diabetes: Oxidative Stress	3	6
Memory Disorders	3	6
Alzheimer's Disease	3	5
Aluminum Toxicity	2	4
Cataract	2	4
Chemotherapy-Induced Toxicity: Cisplatin	2	4
Diabetes: Cataract	3	4
Diabetes: Cognitive Dysfunction	2	4
High Fat Diet	2	4
Lipid Peroxidation	2	4
Gallstones	2	3
Liver Cancer	2	3
Lung Cancer	2	3
Abdominal Obesity (Midsection Fat)	1	2
Aging: Liver	1	2
Allergic Airway Diseases	1	2
Arthritis	1	2
Athletic Performance	1	2
Bisphenol Toxicity	1	2
Cadmium Poisoning	1	2
Cardiomyopathy	1	2
Diabetes: Glycation/A1C	1	2
Diabetic Complications	1	2
Diabetic Nephropathy	1	2
Fatty Liver	1	2
Hepatic Steatosis	1	2
High Fructose Diet	1	2
Human Growth Hormone: Enhancement	1	2
Kidney Damage: Chemically-Induced	1	2
Kidney Diseases	1	2
Liver Damage	1	2
Liver Fibrosis	1	2
Liver: Fatty	1	2
Myocardial Infarction	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Osteoporosis	1	2
Pyrethroid Insecticide Induced Toxicity	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Wound Healing	1	2
Acute T cell Leukemias	1	1
Acute lymphoblastic leukemia (ALL)	1	1
Bacterial Infections and Mycoses	1	1
Breast Cancer	1	1
Cardiovascular Diseases	1	1
Cervical Cancer	1	1
Colon Cancer	1	1
Coronavirus Infection	1	1
Heart Disease	1	1
Ovarian Cancer	1	1
Parkinson's Disease	1	1
Pseudomonas aeruginosa	1	1
Staphylococcus aureus infection	1	1
Hyperthyroidism	1	0

Name	AC	CK
Hypoglycemic Agents	17	99
Hypolipidemic	18	85
Antioxidants	24	54
Galactogogue	2	30
Hepatoprotective	9	26
Anti-Inflammatory Agents	8	23
Anti-Anxiety Agents	3	21
Renoprotective	5	18
Antidepressive Agents	4	15
Neuroprotective Agents	7	13
Apoptotic	7	12
Antinoceceptive	1	10
Appetite Suppresant	1	10
Interleukin-4 upregulation	1	10
Cardioprotective	5	9
Anti-Apoptotic	3	5
Radiosensitizer	1	5
Angiogenesis Inhibitors	2	4
Anticholesteremic Agents	2	4
Antiproliferative	4	4
Chemoprotective Agents	2	4
Malondialdehyde Down-regulation	2	4
Anti-Bacterial Agents	3	3
Anti-Fibrotic	1	2
Anti-metastatic	1	2
Brain-derived neurotrophic factor modulator	1	2
Chemosensitizer	1	2
Cytoprotective	1	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Gastrointestinal Agents	1	2
Insulin Sensitizers	1	2
Osteoprotective	1	2
Pancreato Protective Agents	1	2
Phase II Detoxification Enzyme Inducer	1	2
Secretagogue	1	2
Superoxide Dismutase Up-regulation	1	2
Tumor Necrosis Factor (TNF) Alpha Inhibitor	1	2
Alpha-amylase inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Antineoplastic Agents	1	1
Antioxidant	1	1
Autophagy Up-regulation	1	1
Chemopreventive	1	1
Cytotoxic	1	1
Enzyme Inhibitors	1	1
Telomerase Inhibitor	1	1
Tumor Suppressor Protein p53 Upregulation	1	1

A fenugreek transdermal patch decreases pain score and demand for morphine in post-surgery patients in comparison to diclofenac patch.Feb 04, 2019

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Pubmed Data : J Complement Integr Med. 2019 Feb 5. Epub 2019 Feb 5. PMID: 30721143

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Pubmed Data : J Food Biochem. 2020 Oct 6:e13507. Epub 2020 Oct 6. PMID: 33025616

Article Published Date : Oct 05, 2020

Study Type : Human Study

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Substances : Fenugreek

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

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Fenfuro proved safe and efficacious in ameliorating the symptoms of T2D in humans.Dec 31, 2015

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Pubmed Data : Food Nutr Res. 2016 ;60:32382. Epub 2016 Oct 11. PMID: 27733237

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Substances : Fenugreek

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Plant Extracts

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Fenugreek could be used as adjuvant therapy to anti-diabetic drugs to control blood glucose.Feb 28, 2019

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Pubmed Data : Afr Health Sci. 2019 Mar ;19(1):1594-1601. PMID: 31148988

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Pubmed Data : Int J Mol Sci. 2018 Mar 8 ;19(3). Epub 2018 Mar 8. PMID: 29518003

Article Published Date : Mar 07, 2018

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Pubmed Data : J Med Signals Sens. 2015 Jul-Sep;5(3):176-81. PMID: 26284174

Article Published Date : Jun 30, 2015

Study Type : Human In Vitro

Additional Links

Substances : Fenugreek

Diseases : Cancers: All

Pharmacological Actions : Apoptotic, Radiosensitizer

Additional Keywords : Plant Extracts

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Hyperthyroidism treatment by alternative therapies based on cupping and dietary-herbal supplementation.Aug 11, 2021

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Pubmed Data : Drug Metab Pers Ther. 2021 Aug 12. Epub 2021 Aug 12. PMID: 34388334

Article Published Date : Aug 11, 2021

Study Type : Human: Case Report

Additional Links

Substances : Barley Grass, Dandelion , Fenugreek, Nettle, Royal Jelly, Turmeric

Diseases : Hyperthyroidism

Therapeutic Actions : Cupping

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4-hydroxyisoleucine showed significant and dose-dependent antidepressant effects.Sep 30, 2015

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Dose-dependent effects of fenugreek seed extract on the biochemical and haematological parameters in high-fat diet-fed rats.Jul 31, 2019

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Pubmed Data : Pharmazie. 2007 Apr;62(4):299-304. PMID: 17484288

Article Published Date : Apr 01, 2007

Study Type : Animal Study

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Substances : Fenugreek, Flavonoids, Polyphenols

Diseases : Alcohol Toxicity , Alcoholic Liver Disease

Pharmacological Actions : Phase II Detoxification Enzyme Inducer

Additional Keywords : Plant Extracts

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Fenugreek and a-tocopherol might represent a promising medicinal combination to ameliorate the toxic effects of cadmium exposure.Dec 31, 2014

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Pubmed Data : Folia Morphol (Warsz). 2015 ;74(3):325-34. PMID: 26339813

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Fenugreek, Vitamin E: alpha tocopherol

Diseases : Cadmium Poisoning

Pharmacological Actions : Cytoprotective

Problem Substances : Cadmium

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Fenugreek contains a soluble fiber that improves blood lipid and glucose responses in rats, while also reducing abdominal fat.Nov 01, 2008

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Pubmed Data : Andrologia. 2015 May 21. Epub 2015 May 21. PMID: 25996647

Fenugreek seeds dietary supplementation regulates liver antioxidant defense systems in aging mice.Aug 23, 2020

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Pubmed Data : Vet World. 2020 Aug ;13(8):1732-1736. Epub 2020 Aug 29. PMID: 33061252

Article Published Date : Jul 31, 2020

Study Type : Animal Study

Additional Links

Substances : Fenugreek, Milk Thistle

Diseases : Diabetes Mellitus: Type 2, Hyperglycemia

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic

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Interactive effect of swimming training and fenugreek extract on glycemic indices and lipid profile.Oct 04, 2020

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Pubmed Data : Arch Physiol Biochem. 2020 Oct 5:1-5. Epub 2020 Oct 5. PMID: 33017260

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Pubmed Data : J Basic Clin Physiol Pharmacol. 2015 Aug 15. Epub 2015 Aug 15. PMID: 26280170

Article Published Date : Aug 14, 2015

Study Type : Animal Study, In Vitro Study

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Substances : Fenugreek, Garlic

Diseases : Lipid Peroxidation

Pharmacological Actions : Cardioprotective

Additional Keywords : Natural Substance Synergy

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These findings demonstrated the preventive effect of fenugreek seed extract on fat deposition and dyslipidemia possibly by improvement in glucose and lipid metabolism.Jul 20, 2015

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Pubmed Data : Drug Res (Stuttg). 2015 Jul 21. Epub 2015 Jul 21. PMID: 26198036

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Pubmed Data : Food Nutr Res. 2015 ;59:29717. Epub 2015 Dec 22. PMID: 26699937

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Fenugreek

Diseases : Diabetes Mellitus: Type 2

Therapeutic Actions : Exercise: Swimming, Integrative Medicine

Additional Keywords : Plant Extracts

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A review on therapeutic potentials of Trigonella foenum graecum (fenugreek) and its chemical constituents in neurological disordersMay 14, 2017

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Pubmed Data : Nutr Neurosci. 2017 May 15:1-7. Epub 2017 May 15. PMID: 28504078

Article Published Date : May 14, 2017

Study Type : Review

Additional Links

Substances : Fenugreek

Diseases : Alzheimer's Disease, Anxiety, Depression, Parkinson's Disease

Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents, Neuroprotective Agents

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Antibacterial and anticancer activities of fenugreek seed extract.Nov 30, 2019

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Pubmed Data : Asian Pac J Cancer Prev. 2019 Dec 1 ;20(12):3771-3776. Epub 2019 Dec 1. PMID: 31870120

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Pubmed Data : Biomed Res Int. 2015;2015:914645. Epub 2015 Oct 18. PMID: 26557712

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Fenugreek

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation

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Fenugreek seeds have therapeutic value in the treatment of type 2 diabetic patients. Jan 01, 2009

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Pubmed Data : Int J Vitam Nutr Res. 2009 Jan;79(1):34-9. PMID: 19839001

Article Published Date : Jan 01, 2009

Study Type : Commentary

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Substances : Fenugreek

Diseases : Diabetes Mellitus: Type 2

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Heat stability of the in vitro inhibitory effect of spices on lipase, amylase, and glucosidase enzymes.Jan 31, 2019

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Pubmed Data : Food Sci Nutr. 2019 Feb ;7(2):425-432. Epub 2019 Jan 28. PMID: 30847119

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View the Evidence: 132 Abstracts with Fenugreek Research

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Systematic review of the efficacy of herbal galactogogues.Apr 30, 2013

The results suggest fenugreek has the hypoglycaemic and triglyceride lowering efficacy.Dec 23, 2016

A combination of Fenugreek, Fennel and Melissa extracts improves colic in breastfed infants within 1 week. Apr 01, 2005

A fenugreek transdermal patch decreases pain score and demand for morphine in post-surgery patients in comparison to diclofenac patch.Feb 04, 2019

A novel extract of Fenugreek husk alleviates postmenopausal symptoms and helps to establish the hormonal balance.Jul 12, 2016

A randomized controlled trial of a herbal compound for improving metabolic parameters in diabetic patients with uncontrolled dyslipidemia.Feb 05, 2019

Drinking the fennel tea and fenugreek tea were significantly effective aid to suppress subjective appetite among overweight women in South Korea.Jun 30, 2015

Efficacy of a novel extract of fenugreek seeds in alleviating vasomotor symptoms and depression in perimenopausal women.Oct 05, 2020

Fenfuro proved safe and efficacious in ameliorating the symptoms of T2D in humans.Dec 31, 2015

Fenugreek could be used as adjuvant therapy to anti-diabetic drugs to control blood glucose.Feb 28, 2019

Fenugreek powder may be a useful functional ingredient to reduce postprandial glycemia.Sep 09, 2015

Fenugreek seed intake has some beneficial effects on FPG, SBP, and some liver and kidney function tests in patients with T2DM.Feb 29, 2020

Fenugreek seed intake-mediated improvement in insulin sensitivity correlated with reduction in melanin-concentrating hormone levels.Mar 07, 2018

Fenugreek seeds have a significant therapeutic effect on blood glucose and serum lipid profiles in insulin-dependant type 1 diabetic patients. Apr 01, 1990

Fenugreek seeds improved glucose metabolism, serum lipid profile and adiponectin levels in studied subjects.Dec 31, 2013

Fenugreek seeds improves triglyceride levels, glycemic control and decreases insulin resistance in mild type 2 diabetic patients. Nov 01, 2001

Fenugreek supplementation is an effective nutritional intervention for improving aging male symptoms, anxiety levels, grip strength.May 21, 2020

Fenugreek supplementation significantly improved lipid profile.May 07, 2020

Fenugreek vaginal cream was effective in treating vaginal atrophy.May 31, 2020

Furocyst was efficacious in ameliorating the symptoms of polycystic ovary syndrome.Dec 31, 2014

Maternal galactagogue herbal tea supplementation containing fenugreek seems to be useful for enhancing breast milk production and facilitating infant birth weight regain in early postnatal days.Feb 01, 2011

Supplementation of Fenugreek in prediabetes subjects was associated with lower conversion to diabetes with no adverse effects.Dec 31, 2014

T. foenum-graecum de-husked seed extract may reduce menopausal symptoms in healthy women.Jul 13, 2017

Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function.May 31, 2016

The aqueous extract of fenugreek seeds appears to be effective and safe in treatment of mild asthma.Dec 31, 2017

The effect of berberine and fenugreek seed co-supplementation on inflammatory factor, lipid and glycemic profile in patients with type 2 diabetes mellitus.Aug 22, 2022

The study demonstrated the safety, tolerance, and enhanced efficacy of CGM in comparison with unformulated standard curcumin.May 31, 2016

These findings suggested curcumin combined with fenugreek soluble fiber might delay neuromuscular fatigue.Oct 08, 2020

Trigonella foenum-graecum seed extract could enhance testosterone levels and improve sperm profiles in male volunteers.Dec 31, 2016

Trigonella foenum-graecum seed may provide new alternatives for the clinical management of type II diabetes.Dec 31, 2018

Fenugreek extract can significantly enhance radiation induced apoptosis. Jun 30, 2015

Hyperthyroidism treatment by alternative therapies based on cupping and dietary-herbal supplementation.Aug 11, 2021

4-hydroxyisoleucine showed significant and dose-dependent antidepressant effects.Sep 30, 2015

A polysaccharide extracted from fenugreek had strong wound healing potential.Nov 29, 2016

A sprouts juice and cell-free probiotic extract have promising effects towards hyperglycemia and associated disorders.Jan 31, 2019

A steroidal derivative from Trigonella foenum graecum L. that induces apoptosis in vitro and in vivo.Dec 31, 2018

Amelioration of oxidative stress by dietary fenugreek seeds is potentiated by onion in streptozotocin-induced diabetic rats.Mar 19, 2017

Ameliorative effect of Trigonella roenum graecum on lipid profile, liver histology and LDL-receptor gene expression.Mar 31, 2021

Anticancer activity of aqueous fenugreek seed extract against pancreatic cancer, histological evidence.Aug 31, 2021

Attenuation of diabetic nephropathy by dietary fenugreek and onion.Jun 30, 2019

Cardioprotective effects of Fenugreek seed extract in streptozotocin induced diabetic rats.Dec 31, 2020

Dietary fenugreek and garlic was found to ameliorate the pathological changes in heart tissue and lipid abnormalities in serum and the heart after myocardial infarction.Jul 28, 2015

Dietary fenugreek seed regresses preestablished cholesterol gallstones in mice.Sep 01, 2009

Diosgenin reorganises hyperglycaemia and distorted tissue lipid profile in high-fat diet-streptozotocin-induced diabetic rats.Nov 30, 2015

Diosgenin, a compound isolated from fenugreek, has chemosensitizing activity against human liver cancer cells. Jan 04, 2010

Dose-dependent effects of fenugreek seed extract on the biochemical and haematological parameters in high-fat diet-fed rats.Jul 31, 2019

Extracts of jambul, bitter melon (M. charantia), gymnena and fenugreek (T. gracecum) have antidiabetic and drug sparing activities. Nov 11, 2009

Fenugree protects against selenite-induced oxidative stress in experimental cataractogenesis.Oct 13, 2009

Fenugreek (Trigonella foenum graecum) seed polyphenols protects the liver from alcohol toxicity. Apr 01, 2007

Fenugreek and a-tocopherol might represent a promising medicinal combination to ameliorate the toxic effects of cadmium exposure.Dec 31, 2014

Fenugreek contains a soluble fiber that improves blood lipid and glucose responses in rats, while also reducing abdominal fat.Nov 01, 2008

Fenugreek contains polyphenols which have significant hepatoprotective and liver restorative properties.Oct 01, 2008

Fenugreek counters the effects of high fat diet on gut microbiota.Jan 26, 2020

Fenugreek ethanolic extract can serve as an antidote for dimethoate-induced pancreatic insult.Nov 24, 2017

Fenugreek has a powerful antioxidant effect and may serves as a novel and promising preventive strategy against cisplatin-induced toxicities.Dec 31, 2014

Fenugreek has a protective effecct against alcohol toxicity. Feb 01, 2006

Fenugreek has a protective effect against cypermethrin-induced hepatotoxicity and nephrotoxicity.Apr 01, 2010

Fenugreek reduces oxidative stress in diabetic rats.Sep 01, 2005

Fenugreek reduces the body weight gain induced by a high-fat diet in obese mice.Jun 01, 2005

Fenugreek reduces triglyceride accumulation in the liver of rats, indicating its potential therapeutic value in the treatment of fatty liver.Sep 01, 2009

Fenugreek seed extract ameliorates cognitive deficits in streptozotocin-induced diabetic rats.Jul 19, 2019

Fenugreek seed extract reduces cisplatin induced reproductive toxicity in rats by the suppression of testicular oxidative stress, apoptosis and inflammations.May 20, 2015

Fenugreek seed polyphenolic extract and quercetin compares favorably to metformin in improving insulin signaling, sensitivity and functioning in a rat model. Apr 01, 2009

Fenugreek seed polyphenols inhibit ethanol-induced damage in the rat liver.Nov 01, 2007

Fenugreek seed powder attenuated aluminum chloride-induced tau pathology, oxidative stress, and inflammation.Feb 24, 2017

Fenugreek seed powder nullified aluminium chloride induced memory loss.Dec 31, 2015

Fenugreek seeds attenuate thioacetamide induced liver damage.Apr 30, 2021

Fenugreek seeds can be used as a regular nutrient to alleviate the side effects of ethanol ingestion, in the kidneys, especially for chronic renal failure patients. Dec 31, 2014

Fenugreek seeds dietary supplementation regulates liver antioxidant defense systems in aging mice.Aug 23, 2020

Fenugreek seeds have lipid-lowering and antioxidant effects in high-cholesterol fed rats. Feb 24, 2010

Fenugreek seeds improve swimming endurance in miace through the increase utilization of fatty acids as an energy source. Aug 01, 2006

Fenugreek seeds increase rat growth hormone from rat pituitary cells.Jan 01, 2007

Fenugreek

View the Evidence:
132 Abstracts with Fenugreek Research