Feverfew

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40 Diseases Researched for Feverfew
NameACCKFocus
Migraine Disorders422Locked
Headache: Migraine211Locked
Headache110Locked
Migraines110Locked
Colorectal Cancer15Locked
Breast Cancer33Locked
Leishmaniasis23Locked
Leukemia: Acute myelogenous leukemia (AML) 33Locked
Anxiety12Locked
Chemically-Induced Liver Damage12Locked
Chronic Pain12Locked
Cystic Fibrosis12Locked
Depression12Locked
Diabetic Neuropathy12Locked
Kidney Damage: Chemically-Induced12Locked
Leukemia12Locked
Mastocytoma12Locked
Membranoproliferative glomerulonephritis (MPGN)12Locked
Neuropathic Pain12Locked
Nonalcoholic fatty liver disease (NAFLD)12Locked
Pain12Locked
Proteinuria12Locked
Rhabdomyosarcoma12Locked
Sleep Disorders12Locked
Acute Myeloid Leukemia11Locked
Acute lymphoblastic leukemia (ALL)11Locked
Brain Cancer11Locked
Cancer Stem Cells11Locked
Cervical Cancer11Locked
Coronavirus Infection11Locked
Epilepsy11Locked
Glioblastoma11Locked
Headaches11Locked
Hepatitis C11Locked
Herpes Simplex Virus Type 111Locked
Melanoma11Locked
Melanoma: Metastatic11Locked
Multiple Myeloma11Locked
Pancreatic Cancer11Locked
Skin Cancer11Locked
31 Pharmacological Actions Researched for Feverfew
NameACCKFocus
Prophylactic Agents431Locked
Apoptotic913Locked
Anti-metastatic15Locked
Bcl-2 protein down-regulation15Locked
Bcl-xL down-regulation15Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor15Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor15Locked
NF-kappaB Inhibitor55Locked
Analgesics24Locked
Anti-Inflammatory Agents24Locked
Antioxidants24Locked
Hepatoprotective24Locked
Antiproliferative 33Locked
Interleukin-8 downregulation23Locked
Leishmanicidal23Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor23Locked
Anti-Anxiety Agents12Locked
Antidepressive Agents12Locked
Antineoplastic Agents22Locked
Antiviral Agents22Locked
Hypnotics and Sedatives12Locked
Renoprotective12Locked
Tumor Suppressor Protein p53 Upregulation22Locked
Anticarcinogenic Agents11Locked
Benzodiazepine receptor agonist11Locked
Cyclooxygenase 2 Inhibitors11Locked
Enzyme Inhibitors11Locked
GABA Modulators11Locked
Immunomodulatory11Locked
Interleukin-2 Downregulation11Locked
Interleukin-6 Downregulation11Locked

View the Evidence:
39 Abstracts with Feverfew Research

[+]

A supercritical extract of feverfew is safe and efficacious in migraine prevention. Nov 01, 2005

Pubmed Data : Cephalalgia. 2005 Nov;25(11):1031-41. PMID: 16232154
Article Published Date : Nov 01, 2005
Study Type : Human Study
Additional Links
Substances : Feverfew
Diseases : Migraine Disorders
[+]

Feverfew and white willow are well-tolerated and effective in migraine prevention. Jan 01, 2006

Pubmed Data : Clin Drug Investig. 2006;26(5):287-96. PMID: 17163262
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Feverfew, Willow Bark
Diseases : Migraine Disorders
[+]

Proprietary supplement containing feverfew, coenzyme Q10 and magnesium assessed could be beneficial and safe for the prevention of migraine.Aug 29, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2017 Aug 30 ;17(1):433. Epub 2017 Aug 30. PMID: 28854909
Article Published Date : Aug 29, 2017
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10, Feverfew, Magnesium
Diseases : Headache: Migraine
Pharmacological Actions : Prophylactic Agents
Additional Keywords : Plant Extracts
[+]

Supplementation with a fixed combination of magnesium, vitamin B2, feverfew, Andrographis Paniculata and coenzyme Q10 for episodic migraine prophylaxis. Dec 26, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Med. 2020 Dec 27 ;10(1). Epub 2020 Dec 27. PMID: 33375459
Article Published Date : Dec 26, 2020
Study Type : Human Study
Additional Links
Substances : Andrographis, Coenzyme Q10, Feverfew, Magnesium, Riboflavin (Vitamin B-2)
Diseases : Migraines
Pharmacological Actions : Prophylactic Agents
[+]

This fixed-dose Tanacetum parthenium preparation improved headache frequency and pain intensity in children affected by tension-type headache.Mar 11, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ital J Pediatr. 2019 Mar 12 ;45(1):36. Epub 2019 Mar 12. PMID: 30871574
Article Published Date : Mar 11, 2019
Study Type : Human Study
Additional Links
Substances : Feverfew
Diseases : Headache
Pharmacological Actions : Prophylactic Agents
Additional Keywords : Plant Extracts
[+]

Parthenolide is a potential novel therapeutic agent for aggressive colorectal cancer treatment.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Intest Res. 2017 Apr ;15(2):174-181. Epub 2017 Apr 27. PMID: 28522946
Article Published Date : Mar 31, 2017
Study Type : Human In Vitro
Additional Links
Substances : Feverfew, Parthenolide
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Feverfew extract had potent nephroprotective effects against oxygen free radicals produced through carbon tetrachloride metabolism.Jun 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2018 Jul-Aug;8(4):370-379. PMID: 30377595
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Substances : Feverfew
Diseases : Kidney Damage: Chemically-Induced
Pharmacological Actions : Antioxidants, Renoprotective
[+]

Feverfew extracts could protect against carbon tetrachloride induced liver damage.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Rep. 2017 ;4:455-462. Epub 2017 Aug 30. PMID: 28959674
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Feverfew
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective
[+]

Feverfew extracts represents a promising alternative for the treatment of leishmaniasis.Jul 31, 2014

Pubmed Data : Exp Parasitol. 2014 Aug ;143:18-23. Epub 2014 May 5. PMID: 24810433
Article Published Date : Jul 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
Additional Keywords : Plant Extracts
[+]

Feverfew flower extract behaves as a potent pain reliever in acute, inflammatory, articular and neuropathic pain.Jul 14, 2015

Pubmed Data : Phytomedicine. 2015 Jul 15 ;22(7-8):752-8. Epub 2015 May 27. PMID: 26141762
Article Published Date : Jul 14, 2015
Study Type : Animal Study
Additional Links
Substances : Feverfew
Diseases : Chronic Pain, Neuropathic Pain, Pain
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
Additional Keywords : Plant Extracts
[+]

Parthenin, a compound found within feverfew, is cytotoxic to mastocytoma, leukemia and rhabdomyosarcoma cells. May 01, 1982

Pubmed Data : Planta Med. 1982 May;45(5):23-7. PMID: 17396773
Article Published Date : May 01, 1982
Study Type : Animal Study
Additional Links
Substances : Feverfew
Diseases : Leukemia, Mastocytoma, Rhabdomyosarcoma
[+]

Parthenolide (a compound from Feverfew) prevent proteinura and renal lesions. Oct 01, 2002

Pubmed Data : Am J Pathol. 2002 Oct;161(4):1497-505. PMID: 12368222
Article Published Date : Oct 01, 2002
Study Type : Animal Study
Additional Links
Substances : Feverfew
Diseases : Membranoproliferative glomerulonephritis (MPGN), Proteinuria
[+]

Parthenolide (from Feverfew) may down-regulate excessive inflammation in Cystic FibrosisJun 01, 2007

Pubmed Data : Am J Respir Cell Mol Biol. 2007 Jun;36(6):728-36. Epub 2007 Feb 1.PMID:17272824
Article Published Date : Jun 01, 2007
Study Type : Animal Study
Additional Links
Substances : Feverfew
Diseases : Cystic Fibrosis
[+]

St. John's Wort and feverfew extracts may become new therapeutic perspectives for painful diabetic peripheral neuropathy. Dec 31, 2013

Pubmed Data : Fitoterapia. 2014 Jan ;92:23-33. Epub 2013 Oct 12. PMID: 24125916
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Feverfew, St. Johns Wort
Diseases : Diabetic Neuropathy
Pharmacological Actions : Analgesics
Additional Keywords : Phytotherapy, Plant Extracts
[+]

T. parthenium exerts clear anxiolytic and antidepressant like effects in mice.Feb 13, 2017

Pubmed Data : J Ethnopharmacol. 2017 Feb 14. Epub 2017 Feb 14. PMID: 28213105
Article Published Date : Feb 13, 2017
Study Type : Animal Study
Additional Links
Substances : Feverfew
Diseases : Anxiety, Depression
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
Additional Keywords : Plant Extracts
[+]

Tanacetum parthenium enhances pentobarbital-induced sleeping behaviors.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2020 Jan-Feb;10(1):70-77. PMID: 31921609
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Feverfew
Diseases : Sleep Disorders
Pharmacological Actions : Hypnotics and Sedatives
Additional Keywords : Natural Substance/Drug Synergy
[+]

Treatment of non-alcoholic steatosis using a nutraceutical multitarget formulation.Jun 17, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Jun 18 ;12(6). Epub 2020 Jun 18. PMID: 32570937
Article Published Date : Jun 17, 2020
Study Type : Animal Study
Additional Links
Substances : Choline, Feverfew, Green Coffee Bean, Milk Thistle, Vitamin E: alpha tocopherol
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Cytokine storm in COVID-19 and parthenolide: Preclinical evidence.May 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytother Res. 2020 May 30. Epub 2020 May 30. PMID: 32472655
Article Published Date : May 29, 2020
Study Type : Commentary
Additional Links
Substances : Feverfew, Parthenolide
Diseases : Coronavirus Infection
Pharmacological Actions : Immunomodulatory, Interleukin-2 Downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Cytokine Modulation, Cytokine Storm
[+]

"The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma."Jun 01, 2011

Pubmed Data : Leuk Lymphoma. 2011 Jun ;52(6):1085-97. Epub 2011 Mar 21. PMID: 21417826
Article Published Date : Jun 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Andrographis, Feverfew
Diseases : Cancer Stem Cells, Multiple Myeloma
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Cancer Stem Cells, Plant Extracts
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Elimination of 'dietary triggers' and the inclusion of a number of natural substances may prevent migraines. Jun 01, 2008

Pubmed Data : Mol Cancer Ther. 2008 Jun;7(6):1708-19. PMID: 19454881
Article Published Date : Jun 01, 2008
Study Type : Review
Additional Links
Substances : Alpha-Lipoic Acid, Butterbur, Coenzyme Q10, Feverfew, Magnesium, Riboflavin (Vitamin B-2)
Diseases : Migraine Disorders
[+]

Extracts from the aerial parts of Tanacetum parthenium has in vivo anti-HSV-1 activity and is safe for oral and topical application.Feb 28, 2019

Pubmed Data : Phytomedicine. 2019 Mar 1 ;55:249-254. Epub 2018 Aug 13. PMID: 30668436
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Herpes Simplex Virus Type 1
Pharmacological Actions : Antiviral Agents
[+]

Feverfew contains the compound parthenolide which exhibits antileishmanial activity. Jan 01, 2005

Pubmed Data : Antimicrob Agents Chemother. 2005 Jan;49(1):176-82. PMID: 15616293
Article Published Date : Jan 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
Additional Keywords : Plant Extracts
[+]

Feverfew contains the compound parthenolide which exhibits antiproliferative activities against human and breast cancer cell lines. Jan 01, 2006

Pubmed Data : J Med Food. 2006;9(1):55-61. PMID: 16579729
Article Published Date : Jan 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Apigenin, Feverfew
Diseases : Breast Cancer, Cervical Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Drug-Plant-Vitamin Synergies, Plant Extracts
[+]

Feverfew contains the compound parthenolide which exhibits microtubule-interfering activity in human breast cancer cells. Oct 15, 2004

Pubmed Data : Chem Biol Interact. 2004 Oct 15;149(2-3):165-73. PMID: 15501437
Article Published Date : Oct 15, 2004
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Breast Cancer
Additional Keywords : Drug: Paclitaxel, Drug-Plant-Vitamin Synergies, Plant Extracts
[+]

Feverfew contains the compound parthenolide which has a chemopreventive action against UVB-induced skin caner. Aug 01, 2004

Pubmed Data : Carcinogenesis. 2004 Aug;25(8):1449-58. Epub 2004 Mar 19. PMID: 15033901
Article Published Date : Aug 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors
[+]

Feverfew contains the compound parthenolide which induces cell death in acute myelogenous leukaemia (AML), in vitro - Article 2. Jun 01, 2005

Pubmed Data : Blood. 2005 Jun 1;105(11):4163-9. Epub 2005 Feb 1. PMID: 15687234
Article Published Date : Jun 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antineoplastic Agents, Apoptotic, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Feverfew contains the compound parthenolide which induces cell death in acute myelogenous leukaemia (AML), in vitro. Sep 01, 2005

Pubmed Data : Expert Opin Biol Ther. 2005 Sep;5(9):1147-52. PMID: 16120045
Article Published Date : Sep 01, 2005
Study Type : Commentary
Additional Links
Substances : Feverfew
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor
[+]

Feverfew contains the compound parthenolide which selectively eradicates acute myelogenous leukemia stem and progenitor cells.Dec 15, 2007

Pubmed Data : Blood. 2007 Dec 15;110(13):4427-35. Epub 2007 Sep 5. PMID: 17804695
Article Published Date : Dec 15, 2007
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Selective Cytotoxicity
[+]

Feverfew could be used to reduce migraine frequency.Apr 19, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cochrane Database Syst Rev. 2015 Apr 20 ;4:CD002286. Epub 2015 Apr 20. PMID: 25892430
Article Published Date : Apr 19, 2015
Study Type : Review
Additional Links
Substances : Feverfew
Diseases : Headache: Migraine
[+]

Herbal treatments for migraine: a systematic review of randomised-controlled studies.Apr 19, 2020

Pubmed Data : Phytother Res. 2020 Apr 20. Epub 2020 Apr 20. PMID: 32310327
Article Published Date : Apr 19, 2020
Study Type : Review
Additional Links
Substances : Butterbur, Chamomile, Coriandrum sativum, Curcumin, Feverfew, Lavender, Peppermint, Rose
Diseases : Headaches
Pharmacological Actions : Prophylactic Agents
[+]

Parthenolide (a compound from Feverfew) induces significant programmed cell death in pre-B acute lymphoblastic leukemia (ALL) cell lines. Aug 28, 2007

Pubmed Data : Cancer Lett. 2007 Aug 28;254(1):119-27. Epub 2007 Apr 30. PMID: 17470383
Article Published Date : Aug 28, 2007
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Acute lymphoblastic leukemia (ALL)
Pharmacological Actions : Apoptotic
[+]

Parthenolide induced apoptosis and reduced osteopontin gene expression in U937 cells.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Rep Biochem Mol Biol. 2016 Apr ;4(2):82-8. PMID: 27536701
Article Published Date : Mar 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Acute Myeloid Leukemia
Pharmacological Actions : Apoptotic
Additional Keywords : Gene Expression Regulation
[+]

Parthenolide potentiates the anti-cancer activity of the chemotherapy drug vinorelbine against cancer stem-like cells and breast cancer cell lines.Jul 02, 2008

Pubmed Data : J Control Release. 2008 Jul 2;129(1):18-25. Epub 2008 Apr 4. PMID: 18466993
Article Published Date : Jul 02, 2008
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Drug: Vinorelbine, Drug-Plant-Vitamin Synergies
[+]

Parthenolide, a compound found within feverfew, exhibits anti-hepatitis C virus activity. Jan 01, 2006

Pubmed Data : Bioorg Med Chem. 2006 Jan 1;14(1):83-91. Epub 2005 Sep 2. PMID: 16140536
Article Published Date : Jan 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Hepatitis C
Pharmacological Actions : Antiviral Agents
[+]

Parthenolide, a compound found within Feverfew, induces rapid cell death in glioblastoma cells. Jul 01, 2008

Pubmed Data : Int J Vitam Nutr Res. 2008 Jul-Sep;78(4-5):223-9. PMID: 18277052
Article Published Date : Jul 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Brain Cancer, Glioblastoma
Pharmacological Actions : Apoptotic
[+]

Parthenolide, a compound found within feverfew, inhibits pancreatic cancer cell growth through inhibiting factor-kappa B pathway. Apr 01, 2005

Pubmed Data : Mol Cancer Ther. 2005 Apr;4(4):587-94. PMID: 15827332
Article Published Date : Apr 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Pancreatic Cancer
Pharmacological Actions : NF-kappaB Inhibitor
[+]

Parthenolide, a sesquiterpene lactone from the medical herb feverfew, shows anticancer activity against human melanoma cells in vitro.Feb 01, 2010

Pubmed Data : Melanoma Res. 2010 Feb;20(1):21-34. PMID: 19949351
Article Published Date : Feb 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Melanoma, Melanoma: Metastatic
Pharmacological Actions : Apoptotic
[+]

The therapeutic activity of feverfew on migraines and epilepsy may be due to its GABA-benzodiazepine modulatory effects. Nov 01, 2009

Pubmed Data : Phytother Res. 2009 Nov;23(11):1642-4. PMID: 19441011
Article Published Date : Nov 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Epilepsy, Migraine Disorders
Pharmacological Actions : Benzodiazepine receptor agonist, GABA Modulators
Additional Keywords : Science Confirms Tradition
[+]

Feverfew modulates genes in human monocytic cells, including CCL2, which may explain its antimigraine activity.Nov 01, 2007

Pubmed Data : Can J Physiol Pharmacol. 2007 Nov;85(11):1108-15. PMID: 18066113
Article Published Date : Nov 01, 2007
Additional Links
Substances : Feverfew

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