Fisetin

Name	AC	CK
Oxidative Stress	15	27
Colorectal Cancer	7	19
Inflammation	12	18
Lipopolysaccharide-Induced Toxicity	12	18
Cancers: All	12	13
Parkinson's Disease	8	13
Breast Cancer	8	11
Myocardial Ischemia	6	11
Brain Inflammation	6	10
Gulf War Syndrome	1	10
Stroke: Ischemic	1	10
Aging	3	9
Neurodegenerative Diseases	6	9
Osteoporosis	5	9
Acetaminophen (Tylenol) Toxicity	4	8
Diabetic Complications	3	8
Liver Damage: Drug-Induced	4	8
Ovarian Cancer	6	8
Prostate Cancer	7	8
Alzheimer's Disease	5	7
Chemotherapy-Induced Toxicity: Doxorubicin	3	7
DNA damage	3	7
High Fat Diet	4	7
Kidney Damage	4	7
Liver Cancer	6	7
Lung Cancer	6	7
Breast Cancer: Triple Negative	5	6
Chemically-Induced Liver Damage	3	6
Kidney Fibrosis	3	6
Myocardial Infarction	3	6
Nonalcoholic fatty liver disease (NAFLD)	3	6
Oral Cancer	4	6
Pancreatic Cancer	6	6
Psoriasis	2	6
Sepsis	3	6
Air Pollution Linked Toxicity	1	5
Alcoholic Liver Disease	2	5
Brain: Oxidative Stress	3	5
Hyperglycemia	1	5
Melanoma	4	5
Memory Disorders	3	5
Osteoarthritis	3	5
Aluminum Toxicity	2	4
Arsenic Poisoning	2	4
Asthma	2	4
Atherosclerosis	2	4
Cancers: Drug Resistant	3	4
Cardiomyopathy	2	4
Chronic Kidney Disease (CKD)	2	4
Cognitive Decline/Dysfunction	2	4
Colon Cancer	4	4
Dementia	2	4
Diabetic Nephropathy	2	4
Epilepsy	2	4
Head and Neck Cancer	4	4
Hyperuricemia	2	4
Liver Injury: Ischemia/reperfusion	2	4
Mercury Poisoning	2	4
Osteosarcoma	4	4
Prenatal Chemical Exposures	2	4
Testicular Injury: Chemical/Metal Induced	2	4
Coronavirus Infection	3	3
Glioma	2	3
Hypoxia	2	3
Insulin Resistance	2	3
Kidney Cancer	3	3
Lipid Peroxidation	2	3
Nephropathy	2	3
Obesity	2	3
Skin Cancer	2	3
Aging: Brain	1	2
Alopecia	1	2
Amyotrophic Lateral Sclerosis	1	2
Androgen-Induced Diseases	1	2
Autism	1	2
Autism Spectrum Disorders	1	2
Brain Injury: Traumatic	1	2
Cancer Metastasis	2	2
Carcinoma: Non-Small-Cell Lung	2	2
Cardiac Hypertrophy	1	2
Cardiovascular Diseases	1	2
Cerebral Hemorrhage	1	2
Cerebral Ischemia	1	2
Chemotherapy-Induced Toxicity: Bleomycin	1	2
Chikungunya Virus	2	2
Colitis	1	2
Degenerative Disk Disease	1	2
Dengue	2	2
Depression	1	2
Dermatitis: Contact	1	2
Diabetes Mellitus: Type 2	2	2
Diarrhea	1	2
Drug-Induced Toxicity: Methotrexate	1	2
Endometriosis	1	2
Endometritis	1	2
Endothelial Dysfunction	1	2
Fibromyalgia	1	2
Fibrosis	1	2
Fluoride Toxicity	1	2
Food Allergies	1	2
Gastric Cancer	2	2
Glaucoma	1	2
Hepatic Steatosis	1	2
High Fructose Diet	1	2
Hyperhomocysteinemia	1	2
Hypertension	2	2
Infertility: Male	1	2
Ischemia	1	2
Kidney Damage: Chemically-Induced	1	2
Lead Poisoning	1	2
Leukemia	2	2
Liver Fibrosis	1	2
Myocardial Fibrosis	1	2
Neurological Disorders	2	2
Otitis media	1	2
Ovarian Failure	1	2
Pancreatitis	1	2
Periodontitis	1	2
Polycystic Ovary Syndrome	1	2
Pre-Eclampsia	1	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Salmonella Infections	1	2
Squamous cell carcinoma	2	2
Streptococcus Infections	1	2
Systemic Lupus Erythematosus	1	2
Urticaria	1	2
Allergic Airway Diseases	1	1
Bladder Cancer	1	1
Brain: Microglial Activation	1	1
Central Nervous System Diseases	1	1
Cervical Cancer	1	1
Chemical Exposure	1	1
Cholangiocarcinoma	1	1
Chronic Lymphocytic Leukemia	1	1
Chronic Myeloid Leukemia	1	1
Chronic Obstructive Pulmonary Disease	1	1
Chronic Pain	1	1
Diabetic Retinopathy	1	1
Encephalopathy	1	1
Glioblastoma	1	1
Hair Loss	1	1
Huntington Disease	1	1
Hyperinsulinism	1	1
Laryngeal Cancer	1	1
Leiomyoma	1	1
Leishmaniasis	1	1
Liver Diseases	1	1
Lung Inflammation	1	1
Lung Injury: Smoke-Induced	1	1
Lupus Nephritis	1	1
Macular Degeneration	1	1
Malaria	1	1
Malignant Melanoma	1	1
Melanoma: Metastatic	1	1
Non-Small-Cell Lung Carcinoma	1	1
Promyelocytic leukemia	1	1
Pruritus	1	1
Retinoblastoma	1	1
Smoking	1	1
Spinal Cord Injuries	1	1
Stress	1	1
Uterine Cancer	1	1
Weight Problems	1	1

Name	AC	CK
Anti-Inflammatory Agents	68	135
Antioxidants	61	109
Neuroprotective Agents	44	78
Apoptotic	54	61
Antiproliferative	44	54
Tumor Necrosis Factor (TNF) Alpha Inhibitor	26	52
Cardioprotective	17	32
Hepatoprotective	16	32
Interleukin-1 beta downregulation	17	32
Interleukin-6 Downregulation	15	31
Anti-Apoptotic	15	30
NF-kappaB Inhibitor	17	29
Nrf2 activation	16	26
Chemotherapeutic	11	22
Cyclooxygenase 2 Inhibitors	14	21
Heme oxygenase-1 up-regulation	12	19
Renoprotective	10	18
Matrix metalloproteinase-9 (MMP-9) inhibitor	7	16
Anti-Fibrotic	8	15
Matrix metalloproteinase-2 (MMP-2) inhibitor	5	14
Anti-metastatic	11	13
Chemopreventive	11	12
Chemoprotective Agents	6	12
Interleukin-8 downregulation	2	11
Matrix Metalloproteinase-7 (MMP-7) Inhibitor	2	11
Osteoprotective	6	11
Cell cycle arrest	9	9
Antineoplastic Agents	6	8
Gastrointestinal Agents	4	8
Antiviral Agents	7	7
Autophagy Up-regulation	4	5
Immunomodulatory	3	5
Immunomodulatory: Th17 downregulation	1	5
Interferon Gamma Reducer	1	5
Superoxide Dismutase Up-regulation	3	5
Angiogenesis Inhibitors	3	4
Anticarcinogenic Agents	4	4
Chemosensitizer	4	4
Postaglandin PGE2 downregulation	3	4
Anti-Allergic Agents	2	3
Bcl-2 protein down-regulation	2	3
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	2	3
Radiosensitizer	3	3
Tumor Suppressor Protein p53 Upregulation	3	3
Wnt/β-catenin signaling pathway modulation	2	3
Androgen Antagonists	1	2
Anti-Angiogenic	2	2
Anti-Bacterial Agents	1	2
Anticonvulsants	1	2
Antidepressive Agents	1	2
Antimicrobial	1	2
Catalase Up-Regulation	1	2
Cyclin D1 Down-Regulation	2	2
Hypolipidemic	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	2
Interleukin-1 alpha downregulation	1	2
Interleukin-12 downregulation	1	2
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	2
Osteogenic	1	2
Pancreato Protective Agents	1	2
Prostaglandin PGE2 downregulation	1	2
SIRT1 Activator	1	2
Acetylcholinesterase Inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Antimalarials	1	1
Antinoceceptive	1	1
Autophagy Inhibitors	1	1
Chondroprotective	1	1
Cytoprotective	1	1
Enzyme Inhibitors	1	1
Genoprotective	1	1
Hypoglycemic Agents	1	1
Hypoxia-inducible factor-1 (HIF-1) inhibitor	1	1
Insulin Sensitizers	1	1
Interleukin-4 downregulation	1	1
Interleukin-5 downregulation	1	1
Leishmanicidal	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
Multidrug Resistance Gene Modulators	1	1
Nitric Oxide Inhibitor	1	1
P21 Activation	1	1
STAT3 Inhibitor	1	1
Topoisomerase I inhibitor	1	1
Topoisomerase II Inhibitor	1	1
Vascular Endothelial Growth Factor Inhibitors	1	1
Vascular Endothelial Growth Factor Regulator	1	1
interleukin-13 down-regulation	1	1

[+]

resveratrol may be beneficial in reducing symptoms of Gulf War Illness.Mar 02, 2021

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Pubmed Data : Int J Environ Res Public Health. 2021 Mar 3 ;18(5). Epub 2021 Mar 3. PMID: 33802381

Article Published Date : Mar 02, 2021

Study Type : Human Study

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Substances : Fisetin, Luteolin, Resveratrol

Diseases : Gulf War Syndrome

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Combination treatments with luteolin and fisetin may be a potential candidate for the treatment and prevention of diabetes and its complications.Jun 25, 2017

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Pubmed Data : J Med Food. 2017 Jun 26. Epub 2017 Jun 26. PMID: 28650731

Article Published Date : Jun 25, 2017

Study Type : Human In Vitro

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Substances : Fisetin, Luteolin

Diseases : Diabetic Complications, Hyperglycemia

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance Synergy

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Fisetin inhibits PM2.5-induced apoptosis by inhibiting the ER stress response and production of ROS.Sep 17, 2021

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Targeted fisetin-encapsulated β-cyclodextrin nanosponges for breast cancer.May 11, 2023

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Pubmed Data : Exp Ther Med. 2020 Feb ;19(2):1343-1355. Epub 2019 Dec 13. PMID: 32010308

Pubmed Data : Food Chem Toxicol. 2020 Oct ;144:111590. Epub 2020 Jul 23. PMID: 32710995

Article Published Date : Sep 30, 2020

Study Type : Animal Study

Additional Links

Substances : Fisetin

Diseases : Parkinson's Disease

Pharmacological Actions : Neuroprotective Agents

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Enhanced therapeutic efficacy of a novel self-micellizing nanoformulation-loading fisetin against acetaminophen-induced liver injury.Oct 10, 2021

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Pubmed Data : Nanomedicine (Lond). 2021 Oct 11. Epub 2021 Oct 11. PMID: 34632809

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Pubmed Data : Biomed Pharmacother. 2020 Feb ;122:109772. Epub 2019 Dec 30. PMID: 31918290

Article Published Date : Jan 31, 2020

Study Type : Animal Study

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Substances : Fisetin

Diseases : Kidney Damage, Lipopolysaccharide-Induced Toxicity, Sepsis

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Fisetin alleviates atrial inflammation, remodelling, and vulnerability to atrial fibrillation after myocardial infarction.Nov 29, 2019

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Pubmed Data : Int J Cancer. 2019 Apr 24. Epub 2019 Apr 24. PMID: 31018249

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Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:1005255. Epub 2022 Oct 20. PMID: 36310620

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Fisetin attenuates periodontitis through FGFR1/TLR4/NLRP3 inflammasome pathway.Mar 12, 2021

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Pubmed Data : Int Immunopharmacol. 2021 Mar 13 ;95:107505. Epub 2021 Mar 13. PMID: 33725636

Article Published Date : Mar 12, 2021

Study Type : Animal Study

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Substances : Fisetin

Diseases : Periodontitis

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Fisetin attenuates renal ischemia/reperfusion injury by improving mitochondrial quality, reducing apoptosis and oxidative stress.Feb 07, 2022

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Pubmed Data : J Cell Physiol. 2018 Mar 25. Epub 2018 Mar 25. PMID: 29574877

Article Published Date : Mar 24, 2018

Study Type : Animal Study, In Vitro Study

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Substances : Fisetin

Diseases : Cancers: Drug Resistant, Colorectal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

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Pubmed Data : Cell Biochem Biophys. 2021 Aug 14. Epub 2021 Aug 14. PMID: 34392494

Article Published Date : Aug 13, 2021

Study Type : Animal Study

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Substances : Fisetin

Diseases : Myocardial Ischemia

Pharmacological Actions : Cardioprotective

[+]

Fisetin prevents acetaminophen-induced liver injury by promoting autophagy.Dec 31, 2019

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Pubmed Data : Front Pharmacol. 2020 ;11:162. Epub 2020 Feb 28. PMID: 32184730

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Fisetin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Autophagy Up-regulation, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

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[+]

Natural flavonol fisetin attenuated hyperuricemic nephropathy.Mar 21, 2021

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Pubmed Data : Phytomedicine. 2021 Mar 22:153552. Epub 2021 Mar 22. PMID: 33994251

Article Published Date : Mar 21, 2021

Study Type : Animal Study

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Substances : Fisetin

Diseases : Hyperuricemia, Nephropathy

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Network pharmacology identifies fisetin as a treatment for osteoporosis.Apr 21, 2023

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Pubmed Data : J Microsc Ultrastruct. 2023 ;11(3):161-171. Epub 2023 Feb 7. PMID: 38025186

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Pubmed Data : Acta Pharmacol Sin. 2020 Jul 13. Epub 2020 Jul 13. PMID: 32661350

Article Published Date : Jul 12, 2020

Study Type : Animal Study

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Substances : Fisetin

Diseases : Sepsis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

These results indicate that fisetin prevented acetaminophen -induced hepatotoxicity.Apr 30, 2019

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Pubmed Data : Phytomedicine. 2019 May ;58:152865. Epub 2019 Feb 19. PMID: 30831465

Antiproliferative mechanisms of a polyphenolic combination of kaempferol and fisetin in triple-negative breast cancer cells.Mar 28, 2023

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Pubmed Data : Psychopharmacology (Berl). 2018 Nov 14. Epub 2018 Nov 14. PMID: 30426184

Article Published Date : Nov 13, 2018

Study Type : In Vitro Study

Additional Links

Substances : Fisetin

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

[+]

An overview of recent advances in the neuroprotective potentials of fisetin against diverse insults in neurological diseases.Oct 23, 2023

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Pubmed Data : Mol Biol Rep. 2023 Aug ;50(8):6579-6589. Epub 2023 Jun 21. PMID: 37341918

Article Published Date : Jul 31, 2023

Study Type : In Vitro Study

Additional Links

Substances : Fisetin, Flavonoids

Diseases : Chemical Exposure

Pharmacological Actions : Anti-Apoptotic, Cardioprotective

[+]

Exosomes derived from fisetin-treated keratinocytes mediate hair growth promotion.Jun 17, 2021

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Pubmed Data : Nutrients. 2021 Jun 18 ;13(6). Epub 2021 Jun 18. PMID: 34207142

Article Published Date : Jun 17, 2021

Study Type : In Vitro Study

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Substances : Fisetin

Diseases : Hair Loss

Additional Keywords : Exosomes, Hair Regeneration

[+]

Exploration of potential targets and mechanisms of fisetin in the treatment of non-small-cell lung carcinoma.Dec 31, 2021

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Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:2383527. Epub 2022 Jun 13. PMID: 35733630

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Fisetin

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Antioxidants, Antiproliferative

Additional Keywords : Gene Expression Regulation

[+]

Exploring the underlying mechanisms of fisetin in the treatment of hepatic insulin resistance.Nov 22, 2023

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Pubmed Data : Front Pharmacol. 2022 ;13:927898. Epub 2022 Jun 16. PMID: 35784747

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Fisetin

Diseases : Diabetic Retinopathy, Macular Degeneration

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

[+]

Fisetin attenuates lipopolysaccharide-induced inflammatory responses in macrophage.Dec 31, 2020

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Pubmed Data : Biomed Res Int. 2021 ;2021:5570885. Epub 2021 Apr 13. PMID: 33954178

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Fisetin

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Fisetin can be of potential use for the treatment of pruritus that cannot be treated with histamine receptor blockers alone.May 14, 2018

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Pubmed Data : Life Sci. 2018 May 15 ;201:121-129. Epub 2018 Mar 28. PMID: 29604269

Article Published Date : May 14, 2018

Study Type : In Vitro Study

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Substances : Fisetin

Diseases : Pruritus

Pharmacological Actions : Anti-Inflammatory Agents

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Fisetin can be used in the future, as a target for the treatment of metastasis of human osteosarcoma cells.Apr 30, 2019

Pubmed Data : Int Immunopharmacol. 2008 Mar;8(3):484-94. Epub 2008 Jan 16. PMID: 18279803

Article Published Date : Mar 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Fisetin, Flavonoids

Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Fisetin in cancer: attributes, developmental aspects, and nanotherapeutics. Jan 27, 2023

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Pubmed Data : Pharmaceuticals (Basel). 2023 Jan 28 ;16(2). Epub 2023 Jan 28. PMID: 37259344

Article Published Date : Jan 27, 2023

Study Type : Review

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Substances : Fisetin

Diseases : Cancers: All

Pharmacological Actions : Apoptotic

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Fisetin increases the sensitivity of chemoresistant head and neck carcinoma cells to cisplatin.Jan 10, 2023

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Pubmed Data : Phytother Res. 2023 Jan 11. Epub 2023 Jan 11. PMID: 36631292

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Pubmed Data : Int J Biol Macromol. 2021 Mar 1 ;178:381-393. Epub 2021 Mar 1. PMID: 33662414

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Pubmed Data : Int Immunopharmacol. 2018 May 11 ;60:202-210. Epub 2018 May 11. PMID: 29758489

Article Published Date : May 10, 2018

Study Type : In Vitro Study

Additional Links

Substances : Fisetin

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-8 downregulation, Postaglandin PGE2 downregulation

[+]

Fisetin inhibits the growth and migration in the A549 human lung cancer cell line.Feb 28, 2018

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Pubmed Data : Front Immunol. 2022 ;13:960601. Epub 2022 Nov 17. PMID: 36466895

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Fisetin

Diseases : Lupus Nephritis

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Renoprotective

[+]

Fisetin sensitized human pancreatic cancer cells to gemcitabine-induced cytotoxicityMay 31, 2018

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Pubmed Data : Anticancer Res. 2018 Jun ;38(6):3527-3533. PMID: 29848706

Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory.Oct 30, 2006

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Pubmed Data : Mol Biol Rep. 2023 Sep ;50(9):7489-7500. Epub 2023 Jul 22. PMID: 37480513

Article Published Date : Aug 31, 2023

Study Type : In Vitro Study

Additional Links

Substances : Fisetin, Quercetin

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Natural Substance Synergy

[+]

Neuroimmunomodulatory properties of flavonoids and derivates: a potential action as adjuvants for the treatment of glioblastoma.Jan 03, 2022

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Pubmed Data : Pharmaceutics. 2023 Sep 23 ;15(10). Epub 2023 Sep 23. PMID: 37896136

Article Published Date : Sep 22, 2023

Study Type : In Vitro Study

Additional Links

Substances : Fisetin

Diseases : Stress

Pharmacological Actions : Neuroprotective Agents

[+]

The neuroprotective role of fisetin in different neurological diseases.Jul 14, 2023

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Pubmed Data : Mol Neurobiol. 2023 Jul 15. Epub 2023 Jul 15. PMID: 37453993

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Pubmed Data : Sci Rep. 2020 May 14 ;10(1):7993. Epub 2020 May 14. PMID: 32409692

Article Published Date : May 13, 2020

Study Type : In Vitro Study

Additional Links

Substances : Fisetin

Diseases : Leiomyoma

Pharmacological Actions : Apoptotic

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These findings suggest that the cytoprotective effects of fisetin and luteolin depend on the stressor they need to combat.Jan 08, 2017

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Pubmed Data : J Nutr Biochem. 2017 Jan 9 ;42:37-42. Epub 2017 Jan 9. PMID: 28113103

Article Published Date : Jan 08, 2017

Study Type : In Vitro Study

Additional Links

Substances : Fisetin, Lutein

Diseases : DNA damage, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cytoprotective

[+]

These results suggest fisetin in combination with gemcitabine as a candidate for use in improved anticancer regimens.Jan 10, 2016

Pubmed Data : Pharm Res. 2017 Feb ;34(2):453-461. Epub 2016 Dec 21. PMID: 28004315

View the Evidence: 270 Abstracts with Fisetin Research

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Fisetin could improve the inflammatory status in colorectal cancer patients.Mar 14, 2018

Fisetin prolongs therapy window of brain ischemic stroke using tissue plasminogen activator.Dec 31, 2018

resveratrol may be beneficial in reducing symptoms of Gulf War Illness.Mar 02, 2021

Combination treatments with luteolin and fisetin may be a potential candidate for the treatment and prevention of diabetes and its complications.Jun 25, 2017

Fisetin inhibits PM2.5-induced apoptosis by inhibiting the ER stress response and production of ROS.Sep 17, 2021

Fisetin is a senotherapeutic that extends health and lifespan.Sep 30, 2018

These results suggest that fisetin has a great potential to be developed as an effective and inexpensive agent for the treatment of psoriasis.Sep 14, 2019

Fisetin ameliorates alcohol-induced liver injury.Dec 31, 2021

Fisetin attenuates doxorubicin-induced cardiotoxicity.Apr 25, 2023

Fucoidan/hyaluronic acid cross-linked zein nanoparticles loaded with fisetin as a novel targeted nanotherapy for oral cancer.Jun 29, 2023

Targeted fisetin-encapsulated β-cyclodextrin nanosponges for breast cancer.May 11, 2023

A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic mice. Oct 15, 2008

Amelioration of bleomycin and methotrexate-induced pulmonary toxicity by serratiopeptidase and fisetin.Dec 22, 2020

Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome.Jul 19, 2021

Anti-osteoporosis effect of fisetin against ovariectomy induced osteoporosis.Dec 31, 2021

Attenuation of reserpine-induced fibromyalgia via ROS and serotonergic pathway modulation by fisetin.Jan 31, 2020

Carnosic acid and fisetin combination therapy enhances inhibition of lung cancer through apoptosis induction.Apr 19, 2017

Co-encapsulation of fisetin and cisplatin into liposomes for glioma therapy.Jun 25, 2021

Combining fisetin and ionizing radiation suppresses the growth of mammalian colorectal cancers.Nov 30, 2016

Comparable efficacy of fisetin and vemurafenib for inhibiting melanoma growth was noted in this study.Oct 23, 2018

Connectivity map analysis identifies fisetin as a treatment compound for osteoporosis.Feb 28, 2021

Discovering the effects of fisetin on NF-κB/NLRP-3/NRF-2 molecular pathways in a mouse model of vascular dementia.Jun 18, 2022

Effects of fisetin on allergic contact dermatitis via regulating the balance of Th17/Treg.Dec 31, 2021

Effects of fisetin, a plant-derived flavonoid, on response to oxidative stress, aging, and age-related diseases.Dec 07, 2022

Enhanced oral bioavailability and neuroprotective effect of fisetin through its SNEDDS against rotenone-induced Parkinson's disease.Sep 30, 2020

Enhanced therapeutic efficacy of a novel self-micellizing nanoformulation-loading fisetin against acetaminophen-induced liver injury.Oct 10, 2021

Fisetin administration improves LPS-induced acute otitis media.Jun 30, 2018

Fisetin alleviated bleomycin-induced pulmonary fibrosis.Dec 31, 2019

Fisetin alleviated kidney inflammation and apoptosis to protect against lipopolysaccharide-induced septic acute kidney injury.Jan 31, 2020

Fisetin alleviates atrial inflammation, remodelling, and vulnerability to atrial fibrillation after myocardial infarction.Nov 29, 2019

Fisetin alleviates chronic urticaria by inhibiting mast cell activation via MRGPRX2.Jul 05, 2023

Fisetin alleviates hepatic and adipocyte fibrosis and insulin resistance.Aug 25, 2020

Fisetin alleviates hypoxia and reoxygenation injury in rat hepatocytes.Jun 30, 2017

Fisetin alleviates liver damage, cell apoptosis, and oxidative stress induced by liver hepatic ischemia-reperfusion injury.Jan 31, 2021

Fisetin alleviates oxidative stress after traumatic brain injury.May 21, 2018

Fisetin alleviates thioacetamide-induced hepatic fibrosis.Mar 07, 2022

Fisetin ameliorated high-fat and high-sucrose-induced NAFLD.Mar 11, 2019

Fisetin ameliorates atherosclerosis by regulating PCSK9 and LOX-1 in apoE -/- mice.Dec 31, 2020

Fisetin ameliorates cognitive impairment by activating mitophagy and suppressing neuroinflammation in rats with sepsis-associated encephalopathy.Nov 26, 2021

Fisetin ameliorates endometriosis modulating mast cells derived NLRP-3 inflammasome pathway and oxidative stress.Mar 06, 2023

Fisetin ameliorates fibrotic kidney disease.Sep 10, 2023

Fisetin ameliorates oxidative glutamate testicular toxicity.Nov 30, 2022

Fisetin ameliorates oxidative stress, inflammation and apoptosis in diabetic cardiomyopathy.Mar 14, 2019

Fisetin ameliorates the inflammation and oxidative stress in lipopolysaccharide-induced endometritis.Dec 31, 2020

Fisetin and 5-fluorouracil: Effective combination for PIK3CA-mutant colorectal cancer.Apr 23, 2019

Fisetin and fisetin nanopartical have the effect of anti-ovarian cancer cells.Jun 30, 2018

Fisetin and telmisartan each alone or in low-dose combination alleviate OVA-induced food allergy.Mar 31, 2019

Fisetin attenuates arsenic and fluoride subacute co-exposure induced neurotoxicity.Jun 30, 2023

Fisetin attenuates arsenic-induced hepatic damage.Dec 31, 2021

Fisetin attenuates diabetic nephropathy-induced podocyte injury.Dec 31, 2021

Fisetin attenuates doxorubicin-induced cardiomyopathy.Dec 31, 2020

Fisetin attenuates isoproterenol-induced cardiac ischemic injury.Mar 14, 2019

Fisetin attenuates metabolic dysfunction in mice challenged with a high-fructose diet.Aug 07, 2018

Fisetin attenuates paracetamol-induced hepatotoxicity by regulating CYP2E1 enzyme.Dec 31, 2022

Fisetin attenuates periodontitis through FGFR1/TLR4/NLRP3 inflammasome pathway.Mar 12, 2021

Fisetin attenuates renal ischemia/reperfusion injury by improving mitochondrial quality, reducing apoptosis and oxidative stress.Feb 07, 2022

Fisetin can be considered as a potential cardioprotective agent during the management of carcinoma using doxorubicin anthracyclines.Oct 24, 2018

Fisetin confers cardioprotection against myocardial ischemia reperfusion injury.Dec 31, 2017

Fisetin could be a promising therapeutic candidate for treating Streptococcus suis serotype 2 infection.Dec 31, 2017

Fisetin could effectively suppress proliferation and metastasis of triple negative breast cancer.Dec 31, 2017

Fisetin effectively alleviates intracerebral hemorrhageby downregulating proinflammatory cytokines and attenuating NF-κB signalling.Dec 31, 2017

Fisetin exerts antioxidant and neuroprotective effects in multiple mutant hsod1 models of amyotrophic lateral sclerosis.Mar 16, 2018

Fisetin exerts endothelial and neuroprotective effects against hyperhomocysteinemia induced endothelial dysfunction and vascular dementia.Dec 31, 2016

Fisetin exerts neuroprotection against aluminum chloride induced brain pathology.Feb 28, 2013

Fisetin impedes developmental methylmercury neurotoxicity.Sep 30, 2018

Fisetin improved the hippocampal-dependent synaptic and memory functions in LPS-treated adult mice.Jun 13, 2019

Fisetin improves hyperuricemia-induced chronic kidney disease.Sep 09, 2021

Fisetin induces the upregulation of AKAP12 mRNA and anti-angiogenesis in a patient-derived organoid xenograft model.Oct 02, 2023

Fisetin inhibited tumor growth in athymic nude mouse xenograft model. Mar 24, 2018

Fisetin inhibits cardiac hypertrophy by suppressing oxidative stress.Nov 30, 2018

Fisetin inhibits liver cancer growth in a mouse model.Jun 30, 2017

Fisetin inhibits NLRP3 inflammasome by suppressing TLR4/MD2-mediated mitochondrial ROS production.Jul 27, 2021

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270 Abstracts with Fisetin Research