Flavonoids

Name	AC	CK
Cardiovascular Diseases	27	173
Oxidative Stress	81	170
Hypertension	20	151
Inflammation	67	135
Endothelial Dysfunction	17	92
Colorectal Cancer	15	86
Breast Cancer	33	79
Cholesterol: Oxidation	13	61
Lipopolysaccharide-Induced Toxicity	32	50
Obesity	18	48
Diabetes Mellitus: Type 2	14	46
Arteriosclerosis	7	44
Cognitive Decline/Dysfunction	6	44
Lung Cancer	21	44
Liver Cancer	29	43
Cancers: All	30	41
Stroke	5	41
Depression	14	40
HDL: Low	4	40
Hemorrhoids	4	40
Radiation Induced Illness	13	40
Alzheimer's Disease	22	39
Aging	13	37
DNA damage	14	37
Diabetes Mellitus: Type 2: Prevention	4	33
Coronary Artery Disease	5	32
Thrombosis	4	31
All-Cause Mortality	2	30
Allergic Rhinitis	3	30
Cardiac Mortality	2	30
Cardiovascular Disease: Prevention	3	30
Smoking	3	30
Parkinson's Disease	15	29
Aging: Brain	6	28
Atherosclerosis	9	28
Lipid Peroxidation	18	28
Prostate Cancer	15	28
Colon Cancer	21	25
Aging Skin	5	24
C-Reactive Protein	4	24
Clotting	4	23
Cholesterol: LDL/HDL ratio	3	22
Glaucoma	2	22
Chemically-Induced Liver Damage	12	21
Esophageal Cancer	3	21
Neurodegenerative Diseases	15	21
Athletic Performance: Recovery	2	20
Cancer Mortality	1	20
Chronic Disease	2	20
Deep Vein Thrombosis	2	20
Diabetes: Cardiovascular Illness	2	20
Ocular Hypertension	1	20
Pancreatic Cancer	7	20
Prehypertension	1	20
Rectal Cancer	1	20
Rheumatoid Arthritis	7	19
Insulin Resistance	6	18
Colorectal Cancer: Prevention	3	17
Hypercholesterolemia	5	17
Hyperglycemia	13	17
Myocardial Infarction	5	17
Squamous cell carcinoma	6	17
Asthma	5	16
Hyperlipidemia	9	16
Ovarian Cancer	6	16
Cancer Metastasis	12	15
Diabetic Complications	10	15
Heart Failure	4	15
Brain Inflammation	10	14
Coronavirus Infection	13	14
Hyperuricemia	3	14
Metabolic Syndrome X	3	14
Pesticide Toxicity	3	13
Sunburn	3	13
Arsenic Poisoning	2	12
Bladder Cancer	3	12
Cancers: Drug Resistant	10	12
Cataract	2	12
Helicobacter Pylori Infection	3	12
Menopausal Syndrome	2	12
Osteoporosis	7	12
Pulmonary Diseases	2	12
Cerebral Ischemia	6	11
Chemotherapy-Induced Toxicity: Cisplatin	6	11
Gallbladder Cancer	2	11
Gout	2	11
High Cholesterol	2	11
High Fat Diet	6	11
Laryngeal Cancer	2	11
Periodontal Diseases	2	11
Skin Diseases: Photo-Aging	2	11
Ultraviolet Radiation Induced Damage	9	11
Aflatoxicosis	1	10
Aphthous Ulcer	1	10
Athletic Performance	1	10
Bile Duct Cancer	1	10
Bladder Degeneration	1	10
Blood Platelet Disorders	1	10
Bone Fractures	1	10
Brain Edema	1	10
Cervical Cancer	10	10
Chemotherapy	1	10
Chronic Obstructive Pulmonary Disease	1	10
Climacteric	1	10
Common Cold	1	10
Dental Caries	1	10
Depression	1	10
Dystrophic retinal detachment (DRD)	1	10
Edema	1	10
Erectile Dysfunction	1	10
Eye Diseases: Vitreous Disorders	1	10
Head and Neck Cancer	1	10
Heart Disease: Ischemic	1	10
Hematuria	1	10
Jet Lag	1	10
Leg Edema	1	10
Libido: Low	1	10
Macular Degeneration	1	10
Muscular Dystrophies	1	10
Osteoarthritis: Knee	1	10
Periodontal Wound Healing	1	10
Peripheral vitreochoreoretinal dystrophies (PVCRD)	1	10
Post-Thrombotic Syndrome	1	10
Postmenopausal Disorders: Insomnia	1	10
Postoperative Recovery	1	10
Premenstrual syndrome	1	10
Retinal Detachment	1	10
Sexaul Dysfunction	1	10
Thromboembolism	1	10
Tinnitus	1	10
Venous Thrombosis	1	10
Vericose Veins: Bladder	1	10
Wrinkles	1	10
Alcohol Toxicity	5	9
Brain Ischemia	7	9
Melanoma	7	9
Arthritis	4	8
Carcinoma: Non-Small-Cell Lung	7	8
Colitis	5	8
Coronavirus Disease	7	8
Diabetes Mellitus: Type 1	5	8
Liver Damage	5	8
Oral Cancer	6	8
Advanced Glycation End products (AGE)	5	7
Breast Cancer: Triple Negative	5	7
Gastric Ulcer	4	7
Liver Cancer: Prevention	2	7
Liver Fibrosis	4	7
Memory Disorders	4	7
Nonalcoholic fatty liver disease (NAFLD)	4	7
Breast Cancer: Metastatic	3	6
Glioma	4	6
HIV Infections	6	6
Hydrogen Peroxide Induced Toxicity	6	6
Infertility: Male	3	6
Inflammatory Bowel Diseases	3	6
Lung Injury: Acute	3	6
Mycobacterium tuberculosis	2	6
Myocardial Ischemia	3	6
Neuroblastoma	4	6
Ulcerative Colitis	3	6
Aging: Immunosenecence	3	5
Blastocystis hominis infections	1	5
Cancers: Multi-Drug Resistant	5	5
Diabetes: Oxidative Stress	3	5
Dyslipidemias	3	5
Gastric Cancer	5	5
Glioblastoma	5	5
Osteoarthritis	3	5
Osteosarcoma	5	5
Psoriasis	4	5
Staphylococcus aureus infection	5	5
Tumors	4	5
Acetaminophen (Tylenol) Toxicity	2	4
Alcoholic Liver Disease	2	4
Allergies	3	4
Anaphylaxis	2	4
Anxiety	2	4
Benzo[a]pyrene-induced Toxicity	3	4
Cardiomyopathy	2	4
Chemotherapy-Induced Kidney Damage	2	4
Diabetic Nephropathy	3	4
Escherichia coli Infections	4	4
Fatty Liver	2	4
Hypoxia	3	4
IgE-Mediated Hypersensitivity	2	4
Immune Disorders: Low Immune Function	2	4
Influenza	3	4
Liver Damage: Drug-Induced	2	4
Liver Injury: Ischemia/reperfusion	2	4
Lymphoma	3	4
Promyelocytic leukemia	4	4
Seizures	2	4
Brain Injury: Traumatic	2	3
Brain: Oxidative Stress	2	3
Chemotherapy and Radiation Toxicity	3	3
Cholera	2	3
Dementia	3	3
Dengue	2	3
Diabetes: Cataract	2	3
Dioxin Toxicity	2	3
Eye Diseases	2	3
Kidney Cancer	3	3
Kidney Damage: Drug-Induced	2	3
Liver Disease	2	3
MRSA	2	3
Periodontitis	2	3
Scars	2	3
Severe Acute Respiratory Syndrome	3	3
Skin Cancer	2	3
Snake Bite: Venom Toxicity	2	3
Abdominal Obesity (Midsection Fat)	1	2
Aging: Liver	1	2
Aluminum Toxicity	1	2
Amyotrophic Lateral Sclerosis	2	2
Aspirin-Induced Toxicity	1	2
Atopic Dermatitis	1	2
Autism	1	2
Bacterial Infections	2	2
Bone Diseases	1	2
Brain Injury: Hippocampal Damage	1	2
Brain: Microglial Activation	2	2
Breast Cancer: Lung Metastasis	1	2
Cadmium Poisoning	1	2
Candida Albicans	2	2
Cerebral Vasospasm	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Chikungunya Virus	2	2
Cholangiocarcinoma	2	2
Colon Polyps	1	2
Convulsions	1	2
Cystic Fibrosis	2	2
Diabetes: Cognitive Dysfunction	1	2
Diesel Exhaust Particle Toxicity	1	2
Dopamine Deficiency	1	2
Drug-Induced Toxicity: Indomethacin	1	2
Ehrlich carcinoma	1	2
Enterovirus 71	1	2
Estrogen Dominance	2	2
Fatigue: Excercise-Induced	1	2
Fibrosis	1	2
Food Allergies	1	2
Fructose-Induced Toxicity	1	2
Gastrointestinal Diseases	1	2
Giardiasis	2	2
Heat Stroke	1	2
Hepatic Steatosis	1	2
Hepatitis: Lectin-Induced (concanavalin)	1	2
High Fructose Diet	1	2
Hypothyroidism	1	2
IgA Deficiency	1	2
Infertility: Aging Associated	1	2
Infertility: Female	1	2
Intestinal Diseases	1	2
Intestinal Permeability	2	2
Iron Overload	1	2
Irritable Bowel Syndrome	1	2
Ischemia	1	2
Kidney Damage: Chemically-Induced	1	2
Leaky Gut Syndrome	2	2
Learning disorders	1	2
Leukemia	2	2
Leukemia: Acute myelogenous leukemia (AML)	1	2
Leukemia: Chronic myelogenous leukemia (CML)	1	2
Liver Cirrhosis	1	2
Low Immune Function: Thymus Dysfunction	1	2
Mercury Poisoning	1	2
Mouse Endogenous Retroviruses	1	2
Muscle Damage: Exercise-Induced	1	2
Myasthenia Gravis	1	2
Myocardial Fibrosis	1	2
NSAID-induced toxicity	1	2
Nasopharyngeal Cancer	2	2
Ovariectomy Associated Adverse Changes	1	2
Pesticide-Induced Toxicity: Organophosphates	1	2
Petroleum Exposure And Toxicity	1	2
Prenatal Chemical Exposures	1	2
Prenatal Nutrition: Health of the Offspring	1	2
Prostatic Hyperplasia: Benign	1	2
Pulmonary Fibrosis	1	2
Radiation	2	2
Radiation Induced Illness: Bone Marrow	1	2
Renal Fibrosis	1	2
Sepsis	1	2
Sinusitis	1	2
Skin Cancer: Prevention	1	2
Sperm Quality: Low	1	2
Systemic Lupus Erythematosus	1	2
Thyroid Cancer	2	2
Wound Healing	1	2
Actinic Keratosis	1	1
Acute lymphoblastic leukemia (ALL)	1	1
Allergic Airway Diseases	1	1
Amyloidosis	1	1
Anemia: Hemolytic	1	1
Animal Diseases: Canine Distemper Virus	1	1
Aspergillosis	1	1
Bacillus subtilis infections	1	1
Cancers	1	1
Candida Infection	1	1
Chemotherapy-Induced Toxicity: Bleomycin	1	1
Chemotherapy-Induced Toxicity: Doxorubicin	1	1
Chronic Myeloid Leukemia	1	1
Clostridium Infections	1	1
Copper Toxicity	1	1
Coronaviridae Infections	1	1
Cryptosporidiosis	1	1
Cytomegalovirus Infections	1	1
Diabetes Mellitus: Type 1: Prevention	1	1
Diarrhea	1	1
Dry Eye Syndromes	1	1
Endometrial Cancer	1	1
Epstein-Barr Virus Infections	1	1
Excitotoxicity	1	1
Fatigue	1	1
Glucosephosphate Dehydrogenase Deficiency	1	1
HSV-1	1	1
HSV-2	1	1
Hepatitis Viruses	1	1
High Homocysteine	1	1
Huntington Disease	1	1
Hyperinsulinism	1	1
Hypertension: Pulmonary	1	1
Influenza in Swine	1	1
Kidney Damage	1	1
Klebsiella Infections	1	1
Leishmaniasis	1	1
Leukemia: Monocytic	1	1
Liver Diseases	1	1
Lymphoma: Non-Hodgkin	1	1
Lymphoma: T-cell	1	1
Malaria	1	1
Malignant Melanoma	1	1
Micrococcus luteus infections	1	1
Neurological Conditions	1	1
Neuropathic Pain	1	1
Non-Small-Cell Lung Carcinoma	1	1
Otitis media	1	1
Photooxidative Stress	1	1
Phthalate Toxicity	1	1
Protozoan Infections	1	1
Pseudomonas aeruginosa	1	1
Psychiatric Disorders	1	1
Radiation-Induced Illness: Cesium-137 Exposure	1	1
Respiratory Infections	1	1
Retinoblastoma	1	1
Rhinovirus Infection	1	1
Salmonella Infections	1	1
Sarcopenia	1	1
Schizophrenia	1	1
Seizures: Drug-Induced	1	1
Simian virus 40 (SV40)	1	1
Staphylococcal Infections	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Staphylococcus epidermidis	1	1
Steptococcus Mutans Infections	1	1
Sugar (Sucrose) Toxicity	1	1
Swine Flu Associated Virus	1	1
Tertiary butyl hydroperoxide toxicity	1	1
Testicular Cancer	1	1
Tongue Cancer	1	1
Triglycerides: Elevated	1	1
Vibrio Infections	1	1
Weight Problems	1	1
disease	1	1

Name	AC	CK
Antioxidants	224	469
Anti-Inflammatory Agents	139	241
Chemopreventive	53	216
Neuroprotective Agents	61	149
Apoptotic	124	144
Antiproliferative	116	140
Tumor Necrosis Factor (TNF) Alpha Inhibitor	51	94
Cardioprotective	25	92
NF-kappaB Inhibitor	52	92
Interleukin-1 beta downregulation	33	68
Hepatoprotective	35	63
Interleukin-6 Downregulation	38	63
Platelet Aggregation Inhibitors	7	62
Cyclooxygenase 2 Inhibitors	30	60
Anti-Apoptotic	33	58
Cell cycle arrest	43	58
Antineoplastic Agents	36	52
Hypoglycemic Agents	24	51
Anticarcinogenic Agents	26	46
Hypotensive	2	40
Anti-metastatic	29	39
Antidepressive Agents	13	39
Nrf2 activation	18	38
Antihypertensive Agents	7	35
Radioprotective	16	34
Hypolipidemic	17	27
Analgesics	6	26
Immunomodulatory	14	26
Anticholesteremic Agents	5	25
MicroRNA modulator	5	24
Vasodilator Agents	4	23
Enzyme Inhibitors	18	22
Antiviral Agents	20	21
Chemotherapeutic	19	21
Anti-Bacterial Agents	18	19
Chemosensitizer	16	19
Tumor Suppressor Protein p53 Upregulation	14	18
Anti-Allergic Agents	4	15
Renoprotective	9	15
Anti-Fibrotic	8	14
Matrix metalloproteinase-3 (MMP-3) inhibitor	4	14
Chemoprotective Agents	7	13
Osteoprotective	8	13
Malondialdehyde Down-regulation	6	12
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	2	12
Matrix metalloproteinase-2 (MMP-2) inhibitor	9	12
Photoprotective	9	12
Alpha-glucosidase inhibitor	10	11
Anti-Platelet	2	11
Matrix metalloproteinase-9 (MMP-9) inhibitor	9	11
Nitric Oxide Enhancer	2	11
Vasoprotective	2	11
Anti Inflammatory	2	10
Anti-thrombotic	1	10
Calcium Channel Blockers	1	10
Cardiovascular Agents	1	10
Detoxifier	1	10
Gastroprotective	6	10
Prophylactic Agents	1	10
Gastrointestinal Agents	6	9
Anti-Ulcer Agents	4	8
Heme oxygenase-1 up-regulation	5	8
Nitric Oxide Inhibitor	5	8
Anti-Angiogenic	5	7
Bcl-2 protein down-regulation	5	7
Brain-derived neurotrophic factor modulator	4	7
Antimicrobial	5	6
Antiparasitic Agents	2	6
Glutathione Upregulation	2	6
Interleukin-8 downregulation	4	6
Superoxide Dismutase Up-regulation	4	6
Vascular Endothelial Growth Factor Inhibitors	4	6
Anticonvulsants	3	5
Antifungal Agents	5	5
Autophagy Inhibitors	4	5
Autophagy Up-regulation	5	5
Cyclooxygenase 1 Inhibitor	3	5
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor	1	5
Interleukin-10 downregulation	3	5
Matrix metalloproteinase-1 (MMP-1) inhibitor	4	5
Postaglandin PGE2 downregulation	4	5
Anti-Anxiety Agents	2	4
Anti-Glycation Agents	3	4
Antimutagenic Agents	4	4
Genoprotective	3	4
Interferon Gamma Reducer	2	4
Interleukin-2 Downregulation	2	4
Phase II Detoxification Enzyme Inducer	2	4
Angiogenesis Inhibitors	2	3
Anti-HIV Agents	3	3
Anti-atherogenic	3	3
Antinoceceptive	2	3
Cytoprotective	2	3
Iron Chelating Agents	2	3
STAT3 Inhibitor	3	3
5-Lipoxygenase Inhibitor	2	2
Aldose reductase inhibitor	1	2
Alpha-amylase inhibitor	2	2
Anti-Tumor	1	2
Antidiarrheals	1	2
Appetite Depressants	1	2
Bcl-xL down-regulation	1	2
Caspase-3 Activation	2	2
Catalase Up-Regulation	1	2
Cyclooxygenase Inhibitors	1	2
Cytotoxic	2	2
Dopaminergic	1	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Fertility Agents: Male	1	2
Heme oxygenase-1 inducer	1	2
Immunomodulatory: Th17 downregulation	1	2
Immunostimulatory	2	2
Interleukin-12 downregulation	1	2
Interleukin-17 downregulation	1	2
Interleukin-18 down-regulation	1	2
Interleukin-4 downregulation	2	2
Interleukin-5 downregulation	2	2
Neurominidase Inhibitor	2	2
Proteasome Inhibitors	2	2
Regenerative	2	2
Vascular Cell Adhesion Molecule-1 Inhibitor	2	2
Vascular Endothelial Growth Factor A Inhibitor	1	2
Wnt/β-catenin signaling pathway modulation	2	2
Acetylcholinesterase Inhibitor	1	1
Angiotensin-Converting Enzyme Inhibitors	1	1
Anti-Asthmatic Agents	1	1
Anti-Estrogenic	1	1
Antigiardial agents	1	1
Antioxidant	1	1
Antioxidant Effects	1	1
Antiprotozoal Agents	1	1
Aromatase Inhibitors	1	1
Bax/Bcl2 Ratio: Decrease	1	1
Chondroprotective	1	1
Cytotoxicity	1	1
DNA Repair Up-regulation	1	1
E-cadherin down-regulation	1	1
Estrogen Receptor Agonist	1	1
Expectorants	1	1
Forkhead Transcription Factor Family O (FOXO) Modulator	1	1
Glucagon Like Peptide 1 (GLP-1) Down-Regulation	1	1
Glucagon Like peptide 1 (GLP-1) Up-regulation	1	1
Gluconeogenesis Inhibitor	1	1
Histamine Antagonists	1	1
Histone deacetylase inhibitor	1	1
Hypoxia-inducible factor-1 (HIF-1) inhibitor	1	1
Insulin-releasing	1	1
Leishmanicidal	1	1
Leukotriene Antagonists	1	1
Metal Chelation: Copper	1	1
P-glycoprotein Inhibitors	1	1
P21 Activation	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
Pancreato Protective Agents	1	1
Prostaglandin PGE2 downregulation	1	1
Radiosensitizer	1	1
Sedative effects	1	1
Telomere Protective	1	1
Topoisomerase I inhibitor	1	1
Topoisomerase II Inhibitor	1	1
Transforming growth factor beta (TGF-β) inhibitor	1	1
Transforming growth factor beta (TGF-β) upregulation	1	1
Xanthine oxidase inhibitor	1	1
interleukin-13 down-regulation	1	1

[+]

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2018 Jul 23 ;10(7). Epub 2018 Jul 23. PMID: 30041489

Article Published Date : Jul 22, 2018

Study Type : Meta Analysis

Additional Links

Substances : Apigenin, Flavonoids, Quercetin

Diseases : Colorectal Cancer, Rectal Cancer

Pharmacological Actions : Chemopreventive

[+]

Higher intakes of total flavonoids and subclasses are associated with lower risk of T2DM.Apr 30, 2018

Article Published Date : Nov 01, 2010

Study Type : Human Study

Additional Links

Substances : Flavonoids, Polyphenols

Diseases : Cholesterol: LDL/HDL ratio, Diabetes: Cardiovascular Illness, HDL: Low

[+]

Click here to read the entire abstract

Pubmed Data : Eur J Clin Nutr. 2015 Mar ;69(3):392-8. Epub 2014 Nov 12. PMID: 25387902

Article Published Date : Feb 28, 2015

Study Type : Human Study

Additional Links

Substances : Flavonoids, Polyphenols

Diseases : Hypertension

Additional Keywords : Dietary Modification, Plant Extracts, Risk Reduction

[+]

Consumptions of citrus fruits, strawberries and grapes were found associated with a lower stroke risk in women.Jan 28, 2021

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2021 Jan 29:1-8. Epub 2021 Jan 29. PMID: 33509322

Article Published Date : Jan 28, 2021

Study Type : Human Study

Additional Links

Substances : Flavonoids, Fruit: All, Grape, Strawberry

Diseases : Stroke

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Risk Reduction

[+]

Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans.Jun 02, 2009

Click here to read the entire abstract

Pubmed Data : Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9033-8. Epub 2009 May 18. PMID: 17344491

Article Published Date : Jun 02, 2009

Study Type : Human Study

Additional Links

Substances : Catechin , Flavonoids, Polyphenols

Diseases : Cholesterol: Oxidation, HDL: Low

Pharmacological Actions : Antioxidants

[+]

Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans.Dec 01, 2008

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol.2008 Dec;46(12):3586-92. Epub 2008 Sep 3 PMID: 15454274

Article Published Date : Dec 01, 2008

Study Type : Human Study

Additional Links

Substances : Chocolate, Flavonoids, Polyphenols

Diseases : Cholesterol: LDL/HDL ratio, Cholesterol: Oxidation, HDL: Low

[+]

Flavonoid consumption reduces the risk of esophageal cancer.Jun 01, 2007

Flavonoids from vegetables and fruits may be linked with the reduced risk of colorectal cancer.Sep 30, 2016

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2016 Oct ;116(7):1275-1287. Epub 2016 Sep 21. PMID: 27650133

Article Published Date : Sep 30, 2016

Study Type : Human Study

Additional Links

Substances : Flavonoids, Fruit: All, Vegetables: All

Diseases : Colorectal Cancer, Colorectal Cancer: Prevention

Additional Keywords : COLORECTAL CANCER, Colorectal Cancer: Prevention, Flavonoids, Fruit: All, Risk Reduction, Vegetables: All

[+]

Flavonol intake and cognitive decline in middle-aged adults.Nov 30, 2015

Click here to read the entire abstract

Pubmed Data : J Med Food. 2015 Dec ;18(12):1327-32. Epub 2015 Sep 1. PMID: 26325006

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Clin Nutr. 2012 Oct ;96(4):781-8. Epub 2012 Aug 22. PMID: 22914551

Article Published Date : Sep 30, 2012

Study Type : Human Study

Additional Links

Substances : Anthocyanins, Flavonoids

Diseases : Atherosclerosis, Cardiovascular Diseases, Hypertension

Pharmacological Actions : Antihypertensive Agents, Vasoprotective

[+]

Higher consumption of red wine, tea, peppers, blueberries and strawberries, was associated with reduced risk of total and cause-specific mortality.Jun 12, 2017

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2017 Jun 13:1-8. Epub 2017 Jun 13. PMID: 28606222

Article Published Date : Jun 12, 2017

Study Type : Human Study

Additional Links

Substances : Blueberry, Flavonoids, Red Wine Extract, Strawberry

Diseases : All-Cause Mortality

Additional Keywords : Risk Reduction

[+]

Higher dietary intake of flavonoid may be inversely associated with depressive symptoms.Apr 23, 2018

Higher intakes of anthocyanins and flavonols and their anti-inflammatory effects may be a key component underlying the reduction in risk of certain chronic diseases.May 26, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Modulation of aflatoxin biomarkers in human blood and urine by green tea polyphenols intervention.Jan 31, 2008

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Carcinogenesis. 2008 Feb ;29(2):411-7. Epub 2008 Jan 12. PMID: 18192689

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2006 Sep ;96(3):482-8. PMID: 16925853

Article Published Date : Aug 31, 2006

Study Type : Human Study

Additional Links

Substances : Flavonoids, Onion, Quercetin, Soup

Diseases : Cardiovascular Disease: Prevention, Cardiovascular Diseases, Thrombosis

Pharmacological Actions : Anti-thrombotic, Cardioprotective

[+]

Prevention of edema in long flights with Pycnogenol.Jun 30, 2005

Click here to read the entire abstract

Pubmed Data : Clin Appl Thromb Hemost. 2005 Jul ;11(3):289-94. PMID: 16015414

Click here to read the entire abstract

Pubmed Data : Panminerva Med. 2021 Dec ;63(4):472-477. PMID: 34915691

Article Published Date : Nov 30, 2021

Study Type : Human Study

Additional Links

Substances : Flavonoids, Pycnogenol (Pine Bark)

Diseases : Back Pain

Pharmacological Actions : Analgesics

Additional Keywords : Plant Extracts

[+]

Pycnogenol has antidiabetic action in patients with type 2 diabetes. Oct 08, 2004

Click here to read the entire abstract

Pubmed Data : Life Sci. 2004 Oct 8;75(21):2505-13. PMID: 15363656

[+]

Rooibos tea improves the lipid profile and redox status of adults at risk of developing cardiovascular disease.Jan 07, 2011

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2011 Jan 7 ;133(1):46-52. Epub 2010 Sep 15. PMID: 20833235

Article Published Date : Jan 07, 2011

Study Type : Human Study

Additional Links

Substances : Flavonoids, Polyphenols, Rooibos

Diseases : Cardiovascular Diseases, Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Sea buckthorn leaf extracts protect neuronal PC-12 cells from oxidative stress.Jul 27, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Microbiol Biotechnol. 2017 Jul 28 ;27(7):1257-1265. PMID: 28535611

Article Published Date : Jul 27, 2017

Study Type : Human Study

Additional Links

Substances : Flavonoids, Kaempferol, Quercetin, Sea buckthorn

Diseases : Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease.Jul 10, 2001

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Pubmed Data : Circulation. 2001 Jul 10;104(2):151-6. PMID: 11447078

Pubmed Data : Environ Int. 2016 Nov ;96:167-172. Epub 2016 Aug 28. PMID: 27690147

Article Published Date : Oct 31, 2016

Study Type : Human Study

Additional Links

Substances : Flavonoids, Vegetables: All

Diseases : Breast Cancer

Pharmacological Actions : Chemopreventive

Additional Keywords : Risk Reduction

Problem Substances : Phthalates

[+]

The data support the strategy of flavonoid supplementation to mitigate post-exercise oxidative stress in endurance athletes.Nov 20, 2019

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Pubmed Data : Int J Sport Nutr Exerc Metab. 2019 Nov 21:1-8. Epub 2019 Nov 21. PMID: 31754080

Article Published Date : Nov 20, 2019

Study Type : Human Study

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Substances : Flavonoids

Diseases : Athletic Performance: Recovery , Oxidative Stress

Therapeutic Actions : Exercise: Cycling

Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, MicroRNA modulator, Nrf2 activation

[+]

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Neurology. 2021 09 7 ;97(10):e1041-e1056. Epub 2021 Jul 28. PMID: 34321362

Article Published Date : Jan 06, 2021

Study Type : Human Study

Additional Links

Substances : Flavonoids

Diseases : Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

[+]

These results indicate that flavonoid intake is associated with lower head and neck cancer risk.Jul 18, 2017

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Pubmed Data : J Nutr. 2017 Jul 19. Epub 2017 Jul 19. PMID: 28724656

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Pubmed Data : Cancer Prev Res (Phila). 2011 Jun ;4(6):907-15. Epub 2011 Mar 7. PMID: 21383028

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Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:8987173. Epub 2018 Aug 5. PMID: 30174782

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Okra

Diseases : Brain Ischemia, Cerebral Ischemia

Pharmacological Actions : Antioxidants, Heme oxygenase-1 inducer, Malondialdehyde Down-regulation, Neuroprotective Agents, Nitric Oxide Inhibitor, Nrf2 activation

[+]

Activity of compounds from temperate propolis against Trypanosoma brucei and Leishmania mexicana Jun 25, 2021

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Pubmed Data : Mol Med Rep. 2015 Jul ;12(1):71-6. Epub 2015 Feb 26. PMID: 25738969

Article Published Date : Jun 30, 2015

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Asthma, Inflammation

Pharmacological Actions : Anti-Asthmatic Agents, Anti-Inflammatory Agents

[+]

Allomelanins suppress the tumor cell growth in vitro and in vivo.Aug 01, 1997

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Pubmed Data : Cancer Biother Radiopharm. 1997 Aug;12(4):273-6. PMID: 10851475

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Pubmed Data : Pharm Biol. 2013 May ;51(5):607-13. Epub 2013 Jan 31. PMID: 23363068

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Pubmed Data : J Food Biochem. 2019 Mar ;43(3):e12744. Epub 2018 Dec 13. PMID: 31353567

Article Published Date : Feb 28, 2019

Study Type : Insect Study

Additional Links

Substances : Apple, Flavonoids

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Nrf2 activation

[+]

Apple polyphenol extracts prevent damage to human gastric epithelial cells.Jan 31, 2005

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Pubmed Data : Gut. 2005 Feb ;54(2):193-200. PMID: 15647180

Article Published Date : Jan 31, 2005

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Flavonoids, Polyphenols

Diseases : Drug-Induced Toxicity: Indomethacin, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants, Gastroprotective

Additional Keywords : Plant Extracts

[+]

Apples may exert their colon cancer protective effects through favorably altering gene patterns resulting in protection of cells against toxicological insults. Jun 15, 2008

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Pubmed Data : Int J Cancer. 2008 Jun 15;122(12):2647-55. PMID: 18351577

Astragalin promotes osteoblastic differentiation in MC3T3-E1 cells and bone formation in vivo.Dec 31, 2018

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Pubmed Data : Front Endocrinol (Lausanne). 2019 ;10:228. Epub 2019 Apr 16. PMID: 31040823

Article Published Date : Dec 31, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Flavonoids

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

[+]

Astragalin reduces hexokinase 2 through increasing miR-125b to inhibit the proliferation of hepatocellular carcinoma cells.Jul 25, 2017

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Pubmed Data : J Agric Food Chem. 2017 Jul 26 ;65(29):5961-5972. Epub 2017 Jul 11. PMID: 28654261

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Pubmed Data : Pharmacol Res. 2021 03 ;165:105444. Epub 2021 Jan 22. PMID: 33493657

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Pubmed Data : Front Pharmacol. 2021 ;12:761763. Epub 2021 Nov 8. PMID: 34819863

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Liver Cancer

Pharmacological Actions : Gastrointestinal Agents

Additional Keywords : Chemothapeutic Synergy: Sorafenib, Increased Bioavailability

[+]

Baicalin improves podocyte injury in rats with diabetic nephropathy by inhibiting PI3K/Akt/mTOR signaling pathway.Dec 31, 2020

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Pubmed Data : J Biochem Mol Toxicol. 2021 Aug 19:e22893. Epub 2021 Aug 19. PMID: 34414639

Article Published Date : Aug 18, 2021

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Diabetic Ulcer

Pharmacological Actions : Anti-Ulcer Agents

[+]

Baicalin is able to alleviate osteomyelitis by regulating TLR2. Dec 31, 2017

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Pubmed Data : Pathog Dis. 2018 03 1 ;76(2). PMID: 29253124

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Osteomyelitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Baicalin liposome alleviates lipopolysaccharide-induced acute lung injury.Dec 31, 2019

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Pubmed Data : Mediators Inflamm. 2020 ;2020:8414062. Epub 2020 Nov 11. PMID: 33223957

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View the Evidence: 1451 Abstracts with Flavonoids Research

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"Dietary flavonoid for preventing colorectal neoplasms."Dec 31, 2011

Cocoa products have blood-pressure lowering capacity.Jan 01, 2010

Dark chocolate is superior to placebo in reducing systolic hypertension or diastolic prehypertension.Jan 01, 2010

Flavonoid intake reduces all-cause mortality.Mar 31, 2015

Flavonoids have a promising role in improving visual function in patients with glaucoma and ocular hypertension.Sep 03, 2015

High intake of flavonols may reduce the risk of colon cancer and high intake of flavones may reduce the risk of rectal cancer.Jul 22, 2018

Higher intakes of total flavonoids and subclasses are associated with lower risk of T2DM.Apr 30, 2018

The present study suggests the intake of flavonols and flavones is associated with a decreased risk of breast cancer.Dec 31, 2012

The present systematic review suggests that the dietary intakes of six classes of flavonoids significantly decrease the risk of cardiovascular diseases.Jan 13, 2014

High polyphenol chocolate is effective in improving the atherosclerotic cholesterol profile in patients with diabetes by increasing HDL cholesterol and improving the cholesterol:HDL ratio.Nov 01, 2010

Plasma polyphenols and antioxidants, oxidative DNA damage and endothelial function in a diet and wine intervention study in humans.Dec 31, 1998

"Kidney function in metabolic syndrome may be improved with Pycnogenol®."May 31, 2010

A Chinese green tea polyphenol extract has evident anti-plaque effect.Sep 01, 2000

A combination of apigenin and EGCG prevent colorectal cancer recurrence. Apr 14, 2008

A combination of diosmin and hesperidin significantly reduces bleeding in patients with acute internal hemorrhoids. Jun 01, 2005

A combination of pine bark extract and nattokinase prevents venous thrombosis in long-haul flights.Sep 01, 2003

A flavonoid supplement improves leg health and reduces fluid retention in premenopausal women. Jan 01, 2004

A flavonol-rich diet may decrease the risk of advanced adenoma recurrence.May 31, 2008

A polyphenol-rich beverage reduces symptoms associated with the common cold.Oct 01, 2010

Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysunfction in smokers.Oct 04, 2005

Apple peel extract inhibits the growth of Helicobacter pylori, and attenuates damage to the gastric mucosa caused by neutrophils. Sep 09, 2009

Association of total flavonoid intake with hypo-HDL-cholesterolemia among Korean adults: effect modification by polyunsaturated fatty acid intake.Jan 09, 2020

Auricular acupressure at some specific acupoints can significantly improve the absorption of naringenin and hesperetin in the extracts form C. aurantium L.Apr 30, 2008

Baicalin capsules combined with α-lipoic acid are effective in treating patients with diabetic peripheral neuropathy.Dec 31, 2020

Bilberry has anti-inflammatory properties.Sep 01, 2010

Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate.Sep 01, 2008

Blueberry flavonoid consumption promotes a positive mood and are a possible way to prevent dysphoria and depression.Feb 19, 2017

Cocoa extract supplementation reduced cardiovascular disease death by 27%.Mar 15, 2022

Cocoa inhibits LDL oxidation both in vitro and ex vivo.Apr 06, 1999

Cocoa powder and dark chocolate may favorably affect cardiovascular disease risk status by modestly reducing LDL oxidation susceptibility and increasing serum total antioxidant capacity and HDL-cholesterol concentrations.Nov 01, 2001

Coffee appears to have a beneficial effect on pulmonary function, among non-smokers. Oct 15, 2010

Comparison of centella with flavonoids for treatment of symptoms in hemorrhoidal disease and after surgical intervention.May 13, 2020

Consumption of flavanone-rich citrus juice in quantities commonly consumed can acutely enhance blood flow to the brain in healthy young adults.Nov 30, 2016

Consumption of high flavanol dark chocolate confers modest improvements in cardiovascular function.Jul 31, 2015

Consumption of phytochemical-rich foods may prevent the development of hypertension.Feb 28, 2015

Consumptions of citrus fruits, strawberries and grapes were found associated with a lower stroke risk in women.Jan 28, 2021

Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans.Jun 02, 2009

Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans.Dec 01, 2008

Dark chocolate improves coronary vasomotion and reduces platelet reactivity.Nov 20, 2007

Dietary flavonoid intake and reduced risk of esophageal squamous cell carcinoma.Mar 06, 2021

Dietary flavonoid intake at midlife and healthy aging in women.Nov 30, 2014

Dietary flavonoids improve urinary arsenic elimination among Mexican women.Jun 30, 2018

Flavanols are effective at counteracting mental stress-induced endothelial dysfunction and improving peripheral blood flow during stress.Mar 26, 2021

Flavanone intake is inversely associated with esophageal cancer risk and may account, with vitamin C, for the protective effect of fruit, especially citrus fruit, on esophageal cancer. Apr 10, 2000

Flavonoid antioxidants may have therapeutic value in PVCRD and DRD for the purpose of improving and stabilizing the visual functions and for neuroprotection.Aug 01, 2009

Flavonoid consumption may be beneficial for disease prevention.May 14, 2017

Flavonoid consumption reduces the risk of esophageal cancer.Jun 01, 2007

Flavonoid intake and the risk of age-related cataract in China's Heilongjiang Province.Dec 31, 2014

Flavonoid-rich dark chocolate improves endothelial function and increases plasma antioxidant concentrations in healthy adults. Jun 01, 2004

Flavonoid-rich dark chocolate intake significantly improved coronary circulation in healthy adults.Jan 24, 2009

Flavonoid-rich orange juice intake and altered gut microbiome in young adults with depressive symptoms.Jun 17, 2020

Flavonoids (hesperidin) have therapeutic value in the treatment of bleeding bladder varices.Oct 01, 2003

Flavonoids and omega 3-based compoundhad beneficial effects for muscular dystrophies treatment.Dec 31, 2018

Flavonoids contained in fruits and vegetables, especially flavanones, might reduce the risk of non-allergic rhinitis.Jan 29, 2020

Flavonoids from vegetables and fruits may be linked with the reduced risk of colorectal cancer.Sep 30, 2016

Flavonol intake and cognitive decline in middle-aged adults.Nov 30, 2015

Flavonols and catechins have proved to be the most promising molecules for a potential protective role against prostate cancer.Jul 31, 2018

Hesperidin has therapeutic value in the treatment of recurrent aphthous stomatitis. Apr 01, 2006

High intake of flavonoids is associated with decreased carotid atherosclerosis in middle-aged Finnish men.Sep 30, 2007

Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women.Sep 30, 2012

Higher consumption of red wine, tea, peppers, blueberries and strawberries, was associated with reduced risk of total and cause-specific mortality.Jun 12, 2017

Higher dietary intake of flavonoid may be inversely associated with depressive symptoms.Apr 23, 2018

Higher dietary intakes of flavonols may be associated with reduced risk of developing Alzheimer dementia.Jan 28, 2020

Higher flavonoid intake is associated with lower IL-1β.Jan 29, 2020

Higher flavonoid intakes may be associated with lower depression risk.Dec 31, 2015

Higher intake of black tea and particular classes of flavonoids were associated with lower risk of fracture related hospitalizations in elderly women at high risk of fracture.Aug 11, 2015

Higher intake of flavonoids, particularly from berries, appears to reduce rates of cognitive decline in older adults.Jun 30, 2012

Higher intakes of anthocyanins and flavonols and their anti-inflammatory effects may be a key component underlying the reduction in risk of certain chronic diseases.May 26, 2015

Higher intakes of flavonols and flavanones as well as black tea consumption may be associated with lower risk of ovarian cancer.Oct 31, 2014

Higher intakes of fruit-based flavonoids were associated with a lower risk of nonfatal MI and ischemic stroke in men.Aug 02, 2016

Individuals using the Army Physical Fitness Test while supplementing with Pycnogenol had a lower increase in oxidative stress with a faster recovery to almost normal levels.Nov 30, 2013

Inhibitory effect of a combination of baicalein and quercetin flavonoids against Candida albicans strains isolated from the female reproductive system.May 31, 2022

Flavonoids

View the Evidence:
1451 Abstracts with Flavonoids Research