Flavonoids

Name	AC	CK
Hypertension	15	128
Cardiovascular Diseases	17	108
Oxidative Stress	49	93
Inflammation	33	84
Colorectal Cancer	12	83
Endothelial Dysfunction	14	79
Cholesterol: Oxidation	13	61
HDL: Low	4	40
Radiation Induced Illness	12	38
Arteriosclerosis	6	34
Breast Cancer	19	33
Diabetes Mellitus: Type 2: Prevention	4	33
Coronary Artery Disease	5	32
Diabetes Mellitus: Type 2	9	31
Thrombosis	4	31
All-Cause Mortality	2	30
Cardiovascular Disease: Prevention	3	30
Hemorrhoids	3	30
Obesity	7	29
Depression	7	28
Lipopolysaccharide-Induced Toxicity	14	28
DNA damage	12	26
Cognitive Decline/Dysfunction	4	24
Clotting	4	23
Aging	8	22
C-Reactive Protein	3	22
Cancers: All	21	22
Cholesterol: LDL/HDL ratio	3	22
Colon Cancer	18	22
Glaucoma	2	22
Alzheimer's Disease	15	21
Esophageal Cancer	3	21
Allergic Rhinitis	2	20
Cancer Mortality	1	20
Cardiac Mortality	1	20
Chronic Disease	2	20
Deep Vein Thrombosis	2	20
Diabetes: Cardiovascular Illness	2	20
Ocular Hypertension	1	20
Parkinson's Disease	9	20
Prehypertension	1	20
Rectal Cancer	1	20
Smoking	2	20
Liver Cancer	8	18
Colorectal Cancer: Prevention	3	17
Aging: Brain	4	16
Prostate Cancer	13	16
Insulin Resistance	4	15
Lipid Peroxidation	10	15
Metabolic Syndrome X	3	14
Ovarian Cancer	4	14
Chemically-Induced Liver Damage	7	13
Heart Failure	3	13
Lung Cancer	11	13
Myocardial Infarction	3	13
Pesticide Toxicity	3	13
Rheumatoid Arthritis	3	13
Sunburn	3	13
Aging Skin	3	12
Arsenic Poisoning	2	12
Helicobacter Pylori Infection	3	12
Hyperuricemia	2	12
Menopausal Syndrome	2	12
Gout	2	11
High Cholesterol	2	11
Neurodegenerative Diseases	8	11
Skin Diseases: Photo-Aging	2	11
Stroke	2	11
Aflatoxicosis	1	10
Aphthous Ulcer	1	10
Asthma	1	10
Athletic Performance	1	10
Athletic Performance: Recovery	1	10
Bile Duct Cancer	1	10
Bladder Degeneration	1	10
Blood Platelet Disorders	1	10
Bone Fractures	1	10
Brain Edema	1	10
Chemotherapy	1	10
Chronic Obstructive Pulmonary Disease	1	10
Climacteric	1	10
Common Cold	1	10
Dental Caries	1	10
Depression	1	10
Dystrophic retinal detachment (DRD)	1	10
Edema	1	10
Erectile Dysfunction	1	10
Eye Diseases: Vitreous Disorders	1	10
Gallbladder Cancer	1	10
Head and Neck Cancer	1	10
Heart Disease: Ischemic	1	10
Hematuria	1	10
Jet Lag	1	10
Leg Edema	1	10
Libido: Low	1	10
Macular Degeneration	1	10
Osteoarthritis: Knee	1	10
Peripheral vitreochoreoretinal dystrophies (PVCRD)	1	10
Post-Thrombotic Syndrome	1	10
Postmenopausal Disorders: Insomnia	1	10
Postoperative Recovery	1	10
Premenstrual syndrome	1	10
Pulmonary Diseases	1	10
Retinal Detachment	1	10
Sexaul Dysfunction	1	10
Thromboembolism	1	10
Tinnitus	1	10
Venous Thrombosis	1	10
Vericose Veins: Bladder	1	10
Wrinkles	1	10
Hyperlipidemia	5	9
Pancreatic Cancer	5	9
Brain Inflammation	6	8
Cancers: Drug Resistant	7	8
Hyperglycemia	7	8
Cancer Metastasis	4	7
Gastric Ulcer	4	7
Hypercholesterolemia	4	7
Liver Cancer: Prevention	2	7
Breast Cancer: Metastatic	3	6
Cervical Cancer	6	6
Diabetes Mellitus: Type 1	4	6
Myocardial Ischemia	3	6
Breast Cancer: Triple Negative	3	5
Cancers: Multi-Drug Resistant	5	5
Carcinoma: Non-Small-Cell Lung	5	5
Chemotherapy-Induced Toxicity: Cisplatin	3	5
Diabetic Complications	3	5
Melanoma	4	5
Memory Disorders	3	5
Oral Cancer	3	5
Tumors	4	5
Advanced Glycation End products (AGE)	3	4
Aging: Immunosenecence	2	4
Alcohol Toxicity	2	4
Alcoholic Liver Disease	2	4
Anxiety	2	4
Atherosclerosis	3	4
Cerebral Ischemia	2	4
HIV Infections	4	4
High Fat Diet	2	4
Immune Disorders: Low Immune Function	2	4
Inflammatory Bowel Diseases	2	4
Neuroblastoma	2	4
Seizures	2	4
Ultraviolet Radiation Induced Damage	4	4
Allergies	2	3
Brain Injury: Traumatic	2	3
Brain Ischemia	3	3
Cholera	2	3
Dementia	3	3
Diabetes: Cataract	2	3
Dioxin Toxicity	2	3
Dyslipidemias	2	3
Hydrogen Peroxide Induced Toxicity	3	3
Hypoxia	2	3
Liver Damage	2	3
MRSA	2	3
Nonalcoholic fatty liver disease (NAFLD)	2	3
Osteoporosis	2	3
Snake Bite: Venom Toxicity	2	3
Abdominal Obesity (Midsection Fat)	1	2
Aluminum Toxicity	1	2
Anaphylaxis	1	2
Arthritis	1	2
Aspirin-Induced Toxicity	1	2
Autism	1	2
Bladder Cancer	2	2
Bone Diseases	1	2
Brain Injury: Hippocampal Damage	1	2
Brain: Microglial Activation	2	2
Breast Cancer: Lung Metastasis	1	2
Candida Albicans	2	2
Cardiomyopathy	1	2
Cataract	1	2
Cerebral Vasospasm	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Chikungunya Virus	2	2
Colon Polyps	1	2
Convulsions	1	2
Cystic Fibrosis	2	2
Diabetes: Cognitive Dysfunction	1	2
Diabetic Nephropathy	1	2
Diesel Exhaust Particle Toxicity	1	2
Dopamine Deficiency	1	2
Estrogen Dominance	2	2
Fatty Liver	1	2
Food Allergies	1	2
Fructose-Induced Toxicity	1	2
Giardiasis	2	2
Heat Stroke	1	2
High Fructose Diet	1	2
Hypothyroidism	1	2
IgA Deficiency	1	2
IgE-Mediated Hypersensitivity	1	2
Infertility: Aging Associated	1	2
Infertility: Female	1	2
Infertility: Male	1	2
Intestinal Diseases	1	2
Intestinal Permeability	2	2
Iron Overload	1	2
Irritable Bowel Syndrome	1	2
Ischemia	1	2
Kidney Damage: Chemically-Induced	1	2
Leaky Gut Syndrome	2	2
Learning disorders	1	2
Leukemia	2	2
Leukemia: Acute myelogenous leukemia (AML)	1	2
Leukemia: Chronic myelogenous leukemia (CML)	1	2
Liver Injury: Ischemia/reperfusion	1	2
Low Immune Function: Thymus Dysfunction	1	2
Lymphoma	1	2
Mercury Poisoning	1	2
Mouse Endogenous Retroviruses	1	2
NSAID-induced toxicity	1	2
Osteoarthritis	1	2
Ovariectomy Associated Adverse Changes	1	2
Periodontitis	1	2
Pesticide-Induced Toxicity: Organophosphates	1	2
Petroleum Exposure And Toxicity	1	2
Prenatal Chemical Exposures	1	2
Prenatal Nutrition: Health of the Offspring	1	2
Promyelocytic leukemia	2	2
Prostatic Hyperplasia: Benign	1	2
Radiation Induced Illness: Bone Marrow	1	2
Scars	1	2
Skin Cancer	1	2
Skin Cancer: Prevention	1	2
Sperm Quality: Low	1	2
Squamous cell carcinoma	1	2
Staphylococcus aureus infection	2	2
Systemic Lupus Erythematosus	1	2
Thyroid Cancer	2	2
Wound Healing	1	2
Acute lymphoblastic leukemia (ALL)	1	1
Allergic Airway Diseases	1	1
Amyloidosis	1	1
Amyotrophic Lateral Sclerosis	1	1
Anemia: Hemolytic	1	1
Aspergillosis	1	1
Bacillus subtilis infections	1	1
Bacterial Infections	1	1
Benzo[a]pyrene-induced Toxicity	1	1
Brain: Oxidative Stress	1	1
Cancers	1	1
Candida Infection	1	1
Chemotherapy and Radiation Toxicity	1	1
Cholangiocarcinoma	1	1
Chronic Myeloid Leukemia	1	1
Clostridium Infections	1	1
Colitis	1	1
Copper Toxicity	1	1
Cryptosporidiosis	1	1
Cytomegalovirus Infections	1	1
Epstein-Barr Virus Infections	1	1
Escherichia coli Infections	1	1
Excitotoxicity	1	1
Fatigue	1	1
Gastric Cancer	1	1
Glioblastoma	1	1
Glioma	1	1
Glucosephosphate Dehydrogenase Deficiency	1	1
HSV-1	1	1
HSV-2	1	1
High Homocysteine	1	1
Hyperinsulinism	1	1
Hypertension: Pulmonary	1	1
Influenza in Swine	1	1
Kidney Damage: Drug-Induced	1	1
Klebsiella Infections	1	1
Leishmaniasis	1	1
Liver Disease	1	1
Malaria	1	1
Malignant Melanoma	1	1
Micrococcus luteus infections	1	1
Mycobacterium tuberculosis	1	1
Neurological Conditions	1	1
Non-Small-Cell Lung Carcinoma	1	1
Osteosarcoma	1	1
Protozoan Infections	1	1
Pseudomonas aeruginosa	1	1
Psychiatric Disorders	1	1
Radiation	1	1
Radiation-Induced Illness: Cesium-137 Exposure	1	1
Rhinovirus Infection	1	1
Schizophrenia	1	1
Simian virus 40 (SV40)	1	1
Staphylococcus epidermidis	1	1
Sugar (Sucrose) Toxicity	1	1
Swine Flu Associated Virus	1	1
Tertiary butyl hydroperoxide toxicity	1	1
Testicular Cancer	1	1
Triglycerides: Elevated	1	1
Vibrio Infections	1	1
Weight Problems	1	1

Name	AC	CK
Antioxidants	147	310
Chemopreventive	37	116
Anti-Inflammatory Agents	51	94
Antiproliferative	64	81
Apoptotic	66	79
Neuroprotective Agents	36	68
Platelet Aggregation Inhibitors	7	62
NF-kappaB Inhibitor	22	46
Tumor Necrosis Factor (TNF) Alpha Inhibitor	22	46
Anticarcinogenic Agents	22	40
Hypotensive	2	40
Cell cycle arrest	27	39
Hypoglycemic Agents	15	39
Cyclooxygenase 2 Inhibitors	21	38
Cardioprotective	11	36
Interleukin-1 beta downregulation	15	34
Antineoplastic Agents	21	33
Anti-Apoptotic	15	32
Radioprotective	12	29
Antidepressive Agents	6	27
Hepatoprotective	14	26
Interleukin-6 Downregulation	15	26
Analgesics	4	24
Antihypertensive Agents	5	24
Vasodilator Agents	4	23
Enzyme Inhibitors	17	21
Anti-metastatic	11	19
Anticholesteremic Agents	4	15
Chemotherapeutic	12	13
MicroRNA modulator	3	13
Anti-Allergic Agents	2	12
Anti-Platelet	2	11
Nitric Oxide Enhancer	2	11
Anti Inflammatory	2	10
Anti-Bacterial Agents	9	10
Anti-thrombotic	1	10
Calcium Channel Blockers	1	10
Cardiovascular Agents	1	10
Detoxifier	1	10
Hypolipidemic	7	10
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	10
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	10
Chemosensitizer	8	9
Immunomodulatory	5	9
Tumor Suppressor Protein p53 Upregulation	8	9
Anti-Ulcer Agents	4	8
Antiviral Agents	7	7
Matrix metalloproteinase-2 (MMP-2) inhibitor	4	7
Alpha-glucosidase inhibitor	4	5
Anti-Angiogenic	4	5
Antifungal Agents	5	5
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor	1	5
Interleukin-10 downregulation	3	5
Nitric Oxide Inhibitor	3	5
Nrf2 activation	3	5
Photoprotective	4	5
Renoprotective	3	5
Anti-Anxiety Agents	2	4
Anticonvulsants	2	4
Antimutagenic Agents	4	4
Brain-derived neurotrophic factor modulator	2	4
Chemoprotective Agents	2	4
Genoprotective	3	4
Malondialdehyde Down-regulation	2	4
Phase II Detoxification Enzyme Inducer	2	4
Anti-HIV Agents	3	3
Antimicrobial	2	3
Cyclooxygenase 1 Inhibitor	2	3
Cytoprotective	2	3
5-Lipoxygenase Inhibitor	2	2
Aldose reductase inhibitor	1	2
Alpha-amylase inhibitor	2	2
Anti-Tumor	1	2
Antidiarrheals	1	2
Antinoceceptive	1	2
Caspase-3 Activation	2	2
Cyclooxygenase Inhibitors	1	2
Cytotoxic	2	2
Dopaminergic	1	2
Gastroprotective	2	2
Heme oxygenase-1 up-regulation	1	2
Interferon Gamma Reducer	1	2
Interleukin-4 downregulation	2	2
Iron Chelating Agents	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	2
Proteasome Inhibitors	2	2
Superoxide Dismutase Up-regulation	1	2
Vascular Cell Adhesion Molecule-1 Inhibitor	2	2
Vascular Endothelial Growth Factor A Inhibitor	1	2
Acetylcholinesterase Inhibitor	1	1
Anti-Estrogenic	1	1
Antiprotozoal Agents	1	1
Aromatase Inhibitors	1	1
Cytotoxicity	1	1
DNA Repair Up-regulation	1	1
E-cadherin down-regulation	1	1
Estrogen Receptor Agonist	1	1
Expectorants	1	1
Forkhead Transcription Factor Family O (FOXO) Modulator	1	1
Gastrointestinal Agents	1	1
Glucagon Like Peptide 1 (GLP-1) Down-Regulation	1	1
Glucagon Like peptide 1 (GLP-1) Up-regulation	1	1
Gluconeogenesis Inhibitor	1	1
Glutathione Upregulation	1	1
Histamine Antagonists	1	1
Histone deacetylase inhibitor	1	1
Hypoxia-inducible factor-1 (HIF-1) inhibitor	1	1
Immunostimulatory	1	1
Insulin-releasing	1	1
Interleukin-5 downregulation	1	1
Leishmanicidal	1	1
Leukotriene Antagonists	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
Metal Chelation: Copper	1	1
Neurominidase Inhibitor	1	1
Osteoprotective	1	1
P-glycoprotein Inhibitors	1	1
P21 Activation	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
Postaglandin PGE2 downregulation	1	1
Prostaglandin PGE2 downregulation	1	1
Radiosensitizer	1	1
Sedative effects	1	1
Telomere Protective	1	1
Topoisomerase II Inhibitor	1	1
Vasoprotective	1	1
Wnt/β-catenin signaling pathway modulation	1	1
Xanthine oxidase inhibitor	1	1
interleukin-13 down-regulation	1	1

[+]

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2018 Jul 23 ;10(7). Epub 2018 Jul 23. PMID: 30041489

Article Published Date : Jul 22, 2018

Study Type : Meta Analysis

Additional Links

Substances : Apigenin, Flavonoids, Quercetin

Diseases : Colorectal Cancer, Rectal Cancer

Pharmacological Actions : Chemopreventive

[+]

Higher intakes of total flavonoids and subclasses are associated with lower risk of T2DM.Apr 30, 2018

Article Published Date : Nov 01, 2010

Study Type : Human Study

Additional Links

Substances : Flavonoids, Polyphenols

Diseases : Cholesterol: LDL/HDL ratio, Diabetes: Cardiovascular Illness, HDL: Low

[+]

Click here to read the entire abstract

Pubmed Data : Eur J Clin Nutr. 2015 Mar ;69(3):392-8. Epub 2014 Nov 12. PMID: 25387902

Article Published Date : Feb 28, 2015

Study Type : Human Study

Additional Links

Substances : Flavonoids, Polyphenols

Diseases : Hypertension

Additional Keywords : Dietary Modification, Plant Extracts, Risk Reduction

[+]

Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans.Jun 02, 2009

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Pubmed Data : Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9033-8. Epub 2009 May 18. PMID: 17344491

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Pubmed Data : Am J Clin Nutr. 2014 Dec ;100(6):1489-97. Epub 2014 Oct 29. PMID: 25411284

Article Published Date : Nov 30, 2014

Study Type : Human Study

Additional Links

Substances : Apple, Berries: All, Flavonoids, Onion, Orange

Diseases : Aging, Cancers: All, Cardiovascular Diseases, Diabetes Mellitus: Type 2, Hypertension, Stroke

Additional Keywords : Risk Reduction

[+]

Dietary flavonoids improve urinary arsenic elimination among Mexican women.Jun 30, 2018

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Pubmed Data : Nutr Res. 2018 Jul ;55:65-71. Epub 2018 Apr 21. PMID: 29914629

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Pubmed Data : Phytother Res. 2007 Jun;21(6):501-6. PMID: 19444905

Article Published Date : Jun 01, 2007

Study Type : Human Study

Additional Links

Substances : Anthocyanins, Flavonoids

Diseases : Esophageal Cancer

Additional Keywords : Proanthocyanidins, Risk Reduction

[+]

Flavonoid intake and the risk of age-related cataract in China's Heilongjiang Province.Dec 31, 2014

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Pubmed Data : Food Nutr Res. 2015 ;59:29564. Epub 2015 Dec 11. PMID: 26652740

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Neurol. 2019 ;10:755. Epub 2019 Jul 23. PMID: 31396142

Article Published Date : Dec 31, 2018

Study Type : Human Study

Additional Links

Substances : Flavonoids, Omega-3 Fatty Acids

Diseases : Muscular Dystrophies

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Flavonoids contained in fruits and vegetables, especially flavanones, might reduce the risk of non-allergic rhinitis.Jan 29, 2020

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Pubmed Data : Public Health Nutr. 2020 Jan 30:1-9. Epub 2020 Jan 30. PMID: 31996276

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Pubmed Data : Complement Ther Med. 2018 Aug ;39:14-18. Epub 2018 May 15. PMID: 30012385

Article Published Date : Jul 31, 2018

Study Type : Human Study

Additional Links

Substances : Flavonoids

Diseases : Prostate Cancer

Pharmacological Actions : Chemopreventive

Additional Keywords : Risk Reduction

[+]

Hesperidin has therapeutic value in the treatment of recurrent aphthous stomatitis. Apr 01, 2006

Article Published Date : Jun 12, 2017

Study Type : Human Study

Additional Links

Substances : Blueberry, Flavonoids, Red Wine Extract, Strawberry

Diseases : All-Cause Mortality

Additional Keywords : Risk Reduction

[+]

Higher dietary intake of flavonoid may be inversely associated with depressive symptoms.Apr 23, 2018

Higher intakes of anthocyanins and flavonols and their anti-inflammatory effects may be a key component underlying the reduction in risk of certain chronic diseases.May 26, 2015

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Pubmed Data : Carcinogenesis. 2008 Feb ;29(2):411-7. Epub 2008 Jan 12. PMID: 18192689

Article Published Date : Jan 31, 2008

Click here to read the entire abstract

Pubmed Data : Clin Appl Thromb Hemost. 2005 Jul ;11(3):289-94. PMID: 16015414

Click here to read the entire abstract

Pubmed Data : Life Sci. 2004 Oct 8;75(21):2505-13. PMID: 15363656

[+]

Rooibos tea improves the lipid profile and redox status of adults at risk of developing cardiovascular disease.Jan 07, 2011

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Pubmed Data : J Ethnopharmacol. 2011 Jan 7 ;133(1):46-52. Epub 2010 Sep 15. PMID: 20833235

Article Published Date : Jan 07, 2011

Study Type : Human Study

Additional Links

Substances : Flavonoids, Polyphenols, Rooibos

Diseases : Cardiovascular Diseases, Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Sea buckthorn leaf extracts protect neuronal PC-12 cells from oxidative stress.Jul 27, 2017

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Pubmed Data : J Microbiol Biotechnol. 2017 Jul 28 ;27(7):1257-1265. PMID: 28535611

Article Published Date : Jul 27, 2017

Study Type : Human Study

Additional Links

Substances : Flavonoids, Kaempferol, Quercetin, Sea buckthorn

Diseases : Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease.Jul 10, 2001

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Pubmed Data : Circulation. 2001 Jul 10;104(2):151-6. PMID: 11447078

Pubmed Data : Environ Int. 2016 Nov ;96:167-172. Epub 2016 Aug 28. PMID: 27690147

Article Published Date : Oct 31, 2016

Study Type : Human Study

Additional Links

Substances : Flavonoids, Vegetables: All

Diseases : Breast Cancer

Pharmacological Actions : Chemopreventive

Additional Keywords : Risk Reduction

Problem Substances : Phthalates

[+]

The data support the strategy of flavonoid supplementation to mitigate post-exercise oxidative stress in endurance athletes.Nov 20, 2019

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Pubmed Data : Int J Sport Nutr Exerc Metab. 2019 Nov 21:1-8. Epub 2019 Nov 21. PMID: 31754080

Article Published Date : Nov 20, 2019

Study Type : Human Study

Additional Links

Substances : Flavonoids

Diseases : Athletic Performance: Recovery , Oxidative Stress

Therapeutic Actions : Exercise: Cycling

Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, MicroRNA modulator, Nrf2 activation

[+]

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Nutr. 2017 Jul 19. Epub 2017 Jul 19. PMID: 28724656

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Pubmed Data : J Nutr Biochem. 2007 Apr ;18(4):259-71. Epub 2006 Jul 24. PMID: 16860979

Article Published Date : Mar 31, 2007

Study Type : Human In Vitro

Additional Links

Substances : Chokeberry, Flavonoids, Polyphenols

Diseases : Colorectal Cancer, Colorectal Cancer: Prevention

Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemopreventive

[+]

Flavonoid mixture inhibits Mycobacterium tuberculosis survival and infectivity.Feb 27, 2019

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Pubmed Data : Cancer Prev Res (Phila). 2011 Jun ;4(6):907-15. Epub 2011 Mar 7. PMID: 21383028

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Pharm Biol. 2013 May ;51(5):607-13. Epub 2013 Jan 31. PMID: 23363068

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Pubmed Data : J Food Biochem. 2019 Mar ;43(3):e12744. Epub 2018 Dec 13. PMID: 31353567

Article Published Date : Feb 28, 2019

Study Type : Insect Study

Additional Links

Substances : Apple, Flavonoids

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Nrf2 activation

[+]

Apple polyphenol extracts prevent damage to human gastric epithelial cells.Jan 31, 2005

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Pubmed Data : Gut. 2005 Feb ;54(2):193-200. PMID: 15647180

Article Published Date : Jan 31, 2005

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Flavonoids, Polyphenols

Diseases : Drug-Induced Toxicity: Indomethacin, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants, Gastroprotective

Additional Keywords : Plant Extracts

[+]

Apples may exert their colon cancer protective effects through favorably altering gene patterns resulting in protection of cells against toxicological insults. Jun 15, 2008

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Pubmed Data : Int J Cancer. 2008 Jun 15;122(12):2647-55. PMID: 18351577

Astragalin promotes osteoblastic differentiation in MC3T3-E1 cells and bone formation in vivo.Dec 31, 2018

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Pubmed Data : Front Endocrinol (Lausanne). 2019 ;10:228. Epub 2019 Apr 16. PMID: 31040823

Article Published Date : Dec 31, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Flavonoids

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

[+]

Astragalin reduces hexokinase 2 through increasing miR-125b to inhibit the proliferation of hepatocellular carcinoma cells.Jul 25, 2017

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Pubmed Data : J Agric Food Chem. 2017 Jul 26 ;65(29):5961-5972. Epub 2017 Jul 11. PMID: 28654261

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Pubmed Data : Oncotarget. 2017 Apr 18 ;8(16):26941-26958. PMID: 28199969

Article Published Date : Apr 17, 2017

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Lung Cancer

Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Baccharis dracunculifolia, the main botanical source of Brazilian green propolis, displays antiulcer activity.Apr 01, 2007

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Pubmed Data : J Pharm Pharmacol. 2007 Apr;59(4):603-8. PMID: 17430646

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Pubmed Data : Cancer Res. 2010 May 1;70(9):3594-605. Epub 2010 Apr 13. PMID: 20388778

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Pubmed Data : World J Gastrointest Pharmacol Ther. 2010 Dec 6 ;1(6):123-31. PMID: 21577307

Article Published Date : Dec 06, 2010

Study Type : Animal Study

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Substances : Flavonoids

Diseases : Liver Disease

Therapeutic Actions : antioxidant, Hepatoprotective

Additional Keywords : C. Sempervirens Extract, J. Phoenicea Extract, Liver Enzymes, Plant Extracts

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Pubmed Data : Nutr Neurosci. 2008 Dec;11(6):269-76. PMID: 19000380

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Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2010;56(1):68-71. PMID: 20354349

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Pubmed Data : Cell Biochem Funct. 2015 Jun ;33(4):202-10. Epub 2015 May 11. PMID: 25962994

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Pubmed Data : Lung Cancer. 2010 Jun ;68(3):366-74. Epub 2009 Sep 5. PMID: 19733932

Article Published Date : May 31, 2010

Study Type : Animal Study, In Vitro Study

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Substances : Flavonoids

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Tumor Suppressor Protein p53 Upregulation

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Dietary tricin, a flavone present in rice, oats, barley, and wheat inhibits inflammation-related mouse colon carcinogenesis. Dec 01, 2009

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Pubmed Data : Cancer Prev Res (Phila Pa). 2009 Dec;2(12):1031-8. Epub 2009 Nov 24. PMID: 19934339

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Pubmed Data : Chem Biol Interact. 2019 Apr 1 ;302:123-134. Epub 2019 Feb 19. PMID: 30794797

Article Published Date : Mar 31, 2019

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Milk Thistle

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

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Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models.May 31, 2014

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Pubmed Data : Fitoterapia. 2014 Jun ;95:83-92. Epub 2014 Mar 2. PMID: 24594241

Pubmed Data : Indian J Exp Biol. 2008 Jan;46(1):35-40. PMID: 18697569

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Pubmed Data : J Reprod Med. 2002 Oct;47(10):821-4. PMID: 12418064

Article Published Date : Oct 01, 2002

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Pycnogenol (Pine Bark)

Diseases : Infertility: Male, Sperm Quality: Low

Pharmacological Actions : Antioxidants

[+]

Galangin alleviates liver ischemia-reperfusion injury.Dec 31, 2017

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Pubmed Data : Cancer Med. 2020 Aug ;9(15):5546-5557. Epub 2020 Jun 2. PMID: 32485786

Article Published Date : Jul 31, 2020

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Tumor Suppressor Protein p53 Upregulation

[+]

Galangin provides significant protection against acetaminophen induced liver and kidney damage.Oct 31, 2015

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Pubmed Data : J Med Food. 2015 Nov ;18(11):1187-97. Epub 2015 Jun 4. PMID: 26501381

Article Published Date : Oct 31, 2015

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Pubmed Data : Mutat Res. 2009 Feb 10;661(1-2):25-34. Epub 2008 Nov 6. PMID: 19027755

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Isoliquiritigenin (ISL), a flavonoid chalcone that is present in licorice, shallot, and bean sprouts, has antitumorigenic activities in prostate tumor cells. Feb 01, 2009

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Pubmed Data : J Med Food. 2009 Feb;12(1):8-14. PMID: 19298190

Article Published Date : Feb 01, 2009

Study Type : Animal Study

Additional Links

Substances : Beans: All , Flavonoids, Isoliquiritigenin, Licorice, Shallot, Sprouts

Diseases : Prostate Cancer

Pharmacological Actions : Cell cycle arrest, Enzyme Inhibitors

Additional Keywords : Plant Extracts

[+]

Lemon flavonoid, eriocitrin, suppresses exercise-induced oxidative damage in rat liver.Feb 20, 2003

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Pubmed Data : Life Sci. 2003 Feb 21 ;72(14):1609-16. PMID: 12551749

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Melatonin and pycnogenol have a therapeutic role in the treatment fo endothelial dysfunction.Aug 01, 2003

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Pubmed Data : Int J Mol Med. 2003 Aug;12(2):269-73. PMID: 20421515

Article Published Date : Aug 01, 2003

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Melatonin

Diseases : Endothelial Dysfunction, Hypertension

Pharmacological Actions : Antihypertensive Agents, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor

[+]

Milk thistle sprouts have significant antioxidant value which increases with light exposure. Sep 05, 2005

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Pubmed Data : Br J Cancer. 2005 Sep 5;93(5):590-6. PMID: 17852500

Article Published Date : Sep 05, 2005

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Milk Thistle, Polyphenols, Sprouts

Diseases : Oxidative Stress

Therapeutic Actions : Light Therapy

Pharmacological Actions : Antioxidants

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View the Evidence: 854 Abstracts with Flavonoids Research

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"Dietary flavonoid for preventing colorectal neoplasms."Dec 31, 2011

Cocoa products have blood-pressure lowering capacity.Jan 01, 2010

Dark chocolate is superior to placebo in reducing systolic hypertension or diastolic prehypertension.Jan 01, 2010

Flavonoid intake reduces all-cause mortality.Mar 31, 2015

Flavonoids have a promising role in improving visual function in patients with glaucoma and ocular hypertension.Sep 03, 2015

High intake of flavonols may reduce the risk of colon cancer and high intake of flavones may reduce the risk of rectal cancer.Jul 22, 2018

Higher intakes of total flavonoids and subclasses are associated with lower risk of T2DM.Apr 30, 2018

The present study suggests the intake of flavonols and flavones is associated with a decreased risk of breast cancer.Dec 31, 2012

The present systematic review suggests that the dietary intakes of six classes of flavonoids significantly decrease the risk of cardiovascular diseases.Jan 13, 2014

High polyphenol chocolate is effective in improving the atherosclerotic cholesterol profile in patients with diabetes by increasing HDL cholesterol and improving the cholesterol:HDL ratio.Nov 01, 2010

Plasma polyphenols and antioxidants, oxidative DNA damage and endothelial function in a diet and wine intervention study in humans.Dec 31, 1998

"Kidney function in metabolic syndrome may be improved with Pycnogenol®."May 31, 2010

A Chinese green tea polyphenol extract has evident anti-plaque effect.Sep 01, 2000

A combination of apigenin and EGCG prevent colorectal cancer recurrence. Apr 14, 2008

A combination of diosmin and hesperidin significantly reduces bleeding in patients with acute internal hemorrhoids. Jun 01, 2005

A combination of pine bark extract and nattokinase prevents venous thrombosis in long-haul flights.Sep 01, 2003

A flavonoid supplement improves leg health and reduces fluid retention in premenopausal women. Jan 01, 2004

A flavonol-rich diet may decrease the risk of advanced adenoma recurrence.May 31, 2008

A polyphenol-rich beverage reduces symptoms associated with the common cold.Oct 01, 2010

Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysunfction in smokers.Oct 04, 2005

Apple peel extract inhibits the growth of Helicobacter pylori, and attenuates damage to the gastric mucosa caused by neutrophils. Sep 09, 2009

Association of total flavonoid intake with hypo-HDL-cholesterolemia among Korean adults: effect modification by polyunsaturated fatty acid intake.Jan 09, 2020

Auricular acupressure at some specific acupoints can significantly improve the absorption of naringenin and hesperetin in the extracts form C. aurantium L.Apr 30, 2008

Bilberry has anti-inflammatory properties.Sep 01, 2010

Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate.Sep 01, 2008

Blueberry flavonoid consumption promotes a positive mood and are a possible way to prevent dysphoria and depression.Feb 19, 2017

Cocoa inhibits LDL oxidation both in vitro and ex vivo.Apr 06, 1999

Cocoa powder and dark chocolate may favorably affect cardiovascular disease risk status by modestly reducing LDL oxidation susceptibility and increasing serum total antioxidant capacity and HDL-cholesterol concentrations.Nov 01, 2001

Coffee appears to have a beneficial effect on pulmonary function, among non-smokers. Oct 15, 2010

Comparison of centella with flavonoids for treatment of symptoms in hemorrhoidal disease and after surgical intervention.May 13, 2020

Consumption of flavanone-rich citrus juice in quantities commonly consumed can acutely enhance blood flow to the brain in healthy young adults.Nov 30, 2016

Consumption of high flavanol dark chocolate confers modest improvements in cardiovascular function.Jul 31, 2015

Consumption of phytochemical-rich foods may prevent the development of hypertension.Feb 28, 2015

Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans.Jun 02, 2009

Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans.Dec 01, 2008

Dark chocolate improves coronary vasomotion and reduces platelet reactivity.Nov 20, 2007

Dietary flavonoid intake at midlife and healthy aging in women.Nov 30, 2014

Dietary flavonoids improve urinary arsenic elimination among Mexican women.Jun 30, 2018

Flavanone intake is inversely associated with esophageal cancer risk and may account, with vitamin C, for the protective effect of fruit, especially citrus fruit, on esophageal cancer. Apr 10, 2000

Flavonoid antioxidants may have therapeutic value in PVCRD and DRD for the purpose of improving and stabilizing the visual functions and for neuroprotection.Aug 01, 2009

Flavonoid consumption may be beneficial for disease prevention.May 14, 2017

Flavonoid consumption reduces the risk of esophageal cancer.Jun 01, 2007

Flavonoid intake and the risk of age-related cataract in China's Heilongjiang Province.Dec 31, 2014

Flavonoid-rich dark chocolate improves endothelial function and increases plasma antioxidant concentrations in healthy adults. Jun 01, 2004

Flavonoid-rich dark chocolate intake significantly improved coronary circulation in healthy adults.Jan 24, 2009

Flavonoids (hesperidin) have therapeutic value in the treatment of bleeding bladder varices.Oct 01, 2003

Flavonoids and omega 3-based compoundhad beneficial effects for muscular dystrophies treatment.Dec 31, 2018

Flavonoids contained in fruits and vegetables, especially flavanones, might reduce the risk of non-allergic rhinitis.Jan 29, 2020

Flavonoids from vegetables and fruits may be linked with the reduced risk of colorectal cancer.Sep 30, 2016

Flavonol intake and cognitive decline in middle-aged adults.Nov 30, 2015

Flavonols and catechins have proved to be the most promising molecules for a potential protective role against prostate cancer.Jul 31, 2018

Hesperidin has therapeutic value in the treatment of recurrent aphthous stomatitis. Apr 01, 2006

High intake of flavonoids is associated with decreased carotid atherosclerosis in middle-aged Finnish men.Sep 30, 2007

Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women.Sep 30, 2012

Higher consumption of red wine, tea, peppers, blueberries and strawberries, was associated with reduced risk of total and cause-specific mortality.Jun 12, 2017

Higher dietary intake of flavonoid may be inversely associated with depressive symptoms.Apr 23, 2018

Higher dietary intakes of flavonols may be associated with reduced risk of developing Alzheimer dementia.Jan 28, 2020

Higher flavonoid intake is associated with lower IL-1β.Jan 29, 2020

Higher flavonoid intakes may be associated with lower depression risk.Dec 31, 2015

Higher intake of black tea and particular classes of flavonoids were associated with lower risk of fracture related hospitalizations in elderly women at high risk of fracture.Aug 11, 2015

Higher intake of flavonoids, particularly from berries, appears to reduce rates of cognitive decline in older adults.Jun 30, 2012

Higher intakes of anthocyanins and flavonols and their anti-inflammatory effects may be a key component underlying the reduction in risk of certain chronic diseases.May 26, 2015

Higher intakes of flavonols and flavanones as well as black tea consumption may be associated with lower risk of ovarian cancer.Oct 31, 2014

Higher intakes of fruit-based flavonoids were associated with a lower risk of nonfatal MI and ischemic stroke in men.Aug 02, 2016

Individuals using the Army Physical Fitness Test while supplementing with Pycnogenol had a lower increase in oxidative stress with a faster recovery to almost normal levels.Nov 30, 2013

Intake of flavonoid-rich wine, tea, and chocolate by elderly men and women is associated with better cognitive test performance.Jan 01, 2009

Intake of total polyphenols and some classes of polyphenols is inversely associated with diabetes in elderly People at high cardiovascular disease risk.Mar 08, 2016

L-arginine in combination with Pycnogenol causes a significant improvement in sexual function in men with erectile dysfunction without any side effects.May 01, 2003

Moderate consumption of chocolate might be associated with a lower risk of heart failure in male physicians.Nov 30, 2014

Modulation of aflatoxin biomarkers in human blood and urine by green tea polyphenols intervention.Jan 31, 2008

One week of dark chocolate ingestion improved lipid profiles and decreased platelet reactivity within the total group while reducing inflammation only in women.Jul 01, 1999

People who preferentially consume high amounts of quercetin-containing foods have a reduced risk of thrombosis and potential CVD risk.Aug 31, 2006

Flavonoids

View the Evidence:
854 Abstracts with Flavonoids Research