Folic Acid

Name	AC	CK
High Homocysteine	11	113
Alzheimer's Disease	13	63
Folic Acid/Folate Deficiency	8	55
Cognitive Decline/Dysfunction	6	52
Inflammation	4	41
Polycystic Ovary Syndrome	4	40
Cardiovascular Diseases	2	30
Prenatal Nutrition: Learning/Intelligence of Offspring	2	30
Air Pollution Linked Toxicity	4	24
Hyperhomocysteinemia	3	22
Cervical Cancer	3	21
C-Reactive Protein	1	20
Cervical Dysplasia	2	20
Chronic Pelvic Pain Syndrome	2	20
Congenital Defects	1	20
Coronary Artery Disease	2	20
Erectile Dysfunction	2	20
Insulin Resistance	2	20
Neurologic Disorders	2	20
Peripheral Arterial Disease	2	20
Pre-Eclampsia	2	20
Prenatal Nutrition	1	20
Preterm Birth: Prevention	1	20
Prostate Cancer	2	20
Prostatitis: Chronic	2	20
Stroke	2	20
Homocysteine: Elevated	5	16
Neurodegenerative Diseases	5	16
Endothelial Dysfunction	3	14
Dementia	3	13
Prenatal Nutrition: Health of the Offspring	3	13
Autism Spectrum Disorders	2	12
Colon Cancer	2	12
Hypertension	2	12
Breast Cancer	2	11
Diabetes Mellitus: Type 2	2	11
Drug-Induced Toxicity: Methotrexate	2	11
Migraine Disorders	2	11
Postpartum Depression	2	11
Restless Legs Syndrome	2	11
Stroke: Prevention	2	11
Vitiligo	2	11
Acne	1	10
Anemia	1	10
Arsenic Poisoning	1	10
Arthritis: Rheumatoid	1	10
Birth: Labor & Delivery	1	10
Bladder Cancer	1	10
Buerger Disease	1	10
Cardiovascular Disease	1	10
Carotid Stenosis	1	10
Chemotherapy Induced Myelotoxicity	1	10
Chemotherapy-Induced Toxicity	1	10
Cleft Lip	1	10
Colitis: Ulcerative	1	10
Common variable immunodeficiency (CVID)	1	10
Corticosteroid-Induced Toxicity	1	10
Cortisone Toxicity	1	10
Cystic Fibrosis	1	10
Diabetes Mellitus: Type 1: Prevention	1	10
Drug Induced Toxicity: Metformin	1	10
Endometrial Cancer	1	10
Esophageal Cancer	1	10
Gastritis	1	10
Gastroesophageal Reflux	1	10
Gestational Diabetes	1	10
Giant Cell Arteritis	1	10
Glaucoma	1	10
Headache: Migraine	1	10
Hepatitis	1	10
Hepatitis A	1	10
Hepatitis B	1	10
Hepatitis C	1	10
Hypercholesterolemia	1	10
Hypertension: Pre-Eclampsia Induced	1	10
Hyperuricemia	1	10
Infants: Low Birth Weight	1	10
Intima Media Thickening	1	10
Kidney Transplant	1	10
Laryngeal Cancer	1	10
Lewy Body Disease	1	10
Macular Degeneration	1	10
Mucositis	1	10
Multiple Sclerosis	1	10
Myocardial Infarction	1	10
Neutropenia: Chemotherapy Induced	1	10
Oligomenorrhea	1	10
Pancreatic Cancer	1	10
Peripheral Vascular Diseases	1	10
Polymyalgia Rheumatica	1	10
Postpartum Blood Loss	1	10
Postpartum Hemorrhage	1	10
Pregnancy Complications	1	10
Rheumatoid Arthritis	1	10
Rosacea	1	10
Sleep Apnea: Central	1	10
Small-for-gestational-age infant	1	10
Spina Bifida	1	10
Spinal Cord Diseases	1	10
Spondylitis: Ankylosing	1	10
Squamous cell carcinoma	1	10
Trigeminal Neuralgia	1	10
Vitamin B 12 Deficiency	1	10
Wernicke Encephalopathy	1	10
Prenatal Chemical Exposures	4	8
Aging: Brain	3	5
Aluminum Toxicity	3	5
Atherosclerosis	3	5
Alcohol Toxicity	2	4
Infertility: Male	2	4
Lead Poisoning	2	4
Oxidative Stress	2	4
Spinal Cord Injuries	2	4
Testicular Injury: Chemical/Metal Induced	2	4
DNA damage	2	3
Depression	2	3
Infertility: Female	2	3
Liver Cancer	2	3
Neurodevelopmental Disorders	2	3
Parkinson's Disease	2	3
Anxiety Disorders	1	2
Athletic Performance	1	2
Bacterial Meningitis	1	2
Bisphenol Toxicity	1	2
Bisphenol-A Toxicity	1	2
Brain Injury: Traumatic	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Diabetic Nephropathy	1	2
Drug Toxicity: Methotrexate	1	2
Fatigue: Excercise-Induced	1	2
Fibromyalgia	1	2
High Fat Diet	1	2
Hypertension: Pulmonary	1	2
Hyperthyroidism	1	2
Infertility	1	2
Mobile Phone-Induced Oxidative Stress	1	2
Pneumococcal Infections	1	2
Right Ventricular Hypertrophy	1	2
Seizures	1	2
Sleep Disorders	1	2
Aging	1	1
Amyotrophic Lateral Sclerosis	1	1
Autism	1	1
Cancers: All	1	1
Depressive Disorder	1	1
Diabetic Neuropathy	1	1
Hypoxia	1	1
Inflammatory Bowel Diseases	1	1
Leukemia	1	1
Melanoma	1	1
Menstrual Migraine	1	1
Migraine: Menstrual Cycle Induced	1	1
Mitochondrial Dysfunction	1	1
Nicotine/Tobacco Toxicity	1	1
Psoriasis	1	1
Stroke: Ischemic	1	1

Name	AC	CK
Anti-Inflammatory Agents	16	103
Neuroprotective Agents	23	80
Chemopreventive	6	43
Antioxidants	18	40
Analgesics	2	20
Cardioprotective	6	19
Interleukin-1 beta downregulation	3	14
Tumor Necrosis Factor (TNF) Alpha Inhibitor	2	12
Chemotherapeutic	2	11
Antineoplastic Agents	1	10
Hypoglycemic Agents	1	10
Hypolipidemic	1	10
Interleukin-10 upregulation	1	10
Interleukin-6 Downregulation	1	10
Prophylactic Agents	1	10
Proton Pump Inhibitor	1	10
Uricosuric Agents	1	10
Cytoprotective	3	6
Hepatoprotective	3	6
Anti-Apoptotic	5	5
NF-kappaB Inhibitor	2	4
Telomere Protective	2	4
Apoptotic	2	3
Radioprotective	2	3
Anti-atherogenic	1	2
Anticarcinogenic Agents	1	2
Anticonvulsants	1	2
Antidepressive Agents	1	2
Antimutagenic Agents	1	2
Antiproliferative	1	2
Brain-derived neurotrophic factor modulator	1	2
Chemoprotective Agents	1	2
Fertility Agents: Male	1	2
Genoprotective	1	2
Malondialdehyde Down-regulation	1	2
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	2
Nitric Oxide Enhancer	1	2
Regenerative	1	2
Renoprotective	1	2
Anti-metastatic	1	1
Antinoceceptive	1	1
Chemosensitizer	1	1
MicroRNA modulator	1	1
Pancreato Protective Agents	1	1

[+]

Beneficial effects of folic acid on inflammatory markers in the patients with metabolic syndrome.Dec 27, 2022

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Pubmed Data : Int Heart J. 2016 Nov 9. Epub 2016 Aug 9. PMID: 27829639

Article Published Date : Nov 08, 2016

Study Type : Meta Analysis

Additional Links

Substances : Folic Acid

Diseases : Congenital Defects

Additional Keywords : Risk Reduction

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Folic aicd combined with vitamin B6 and B12 treatment significantly reduced plasma homocysteine levelMay 31, 2015

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Pubmed Data : Zhonghua Xin Xue Guan Bing Za Zhi. 2015 Jun ;43(6):554-61. PMID: 26420127

[+]

A combination of nicotinamide 750 mg, zinc 25 mg, copper 1.5 mg, and folic acid 500 microg, marketed as Nicomide, appears to be an effective oral therapy for the treatment of acne vulgaris and rosacea. Jan 01, 2006

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Pubmed Data : Cutis. 2006 Jan;77(1 Suppl):17-28. PMID: 16871775

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Substances : Copper, Folic Acid , Vitamin B-3 (Niacin), Zinc

Diseases : Acne, Rosacea

Pharmacological Actions : Anti-Inflammatory Agents

[+]

A dietary supplement containing melatonin, l-tryptophan, vitamin B6, folic acid, vitamin B12, methionine and betaine, is superior to omeprazole in treating GERD. Oct 01, 2006

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Pubmed Data : J Pineal Res. 2006 Oct;41(3):195-200. PMID: 16948779

Article Published Date : Oct 01, 2006

Study Type : Human Study

Additional Links

Substances : Betaine , Folic Acid , Melatonin, Methionine, Tryptophan, Vitamin B-12, Vitamin B-6

Diseases : Gastroesophageal Reflux

Pharmacological Actions : Proton Pump Inhibitor

Additional Keywords : Superiority of Natural Substances versus Drugs

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A maternal daily intake of 400 µg folic acid alone significantly reduced the risks of infant low birth weight and small-for-gestational-age status.May 21, 2017

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Pubmed Data : J Pediatr. 2017 May 22. Epub 2017 May 22. PMID: 28545876

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Pubmed Data : J Am Heart Assoc. 2018 May 18 ;7(11). Epub 2018 May 18. PMID: 29776960

Article Published Date : May 17, 2018

Study Type : Human Study

Additional Links

Substances : Folic Acid , Vitamin B-12, Vitamin B-6

Diseases : Endothelial Dysfunction, Homocysteine: Elevated

Pharmacological Actions : Anti-Inflammatory Agents

[+]

D-chiro-inositol plus folic acid oral supplementation can improve metabolic control in overweight T1D patients.Dec 31, 2016

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Pubmed Data : Acta Diabetol. 2017 04 ;54(4):361-365. Epub 2016 Dec 30. PMID: 28039583

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Substances : D-Chiro-Inositol, Folic Acid

Diseases : Diabetes Mellitus: Type 1: Prevention, Insulin Resistance

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Decreased folic acid might possibly be one of the novel risk factors for erectile dysfunction.Nov 02, 2020

Pubmed Data : Am J Clin Nutr. 2017 Feb 1. Epub 2017 Feb 1. PMID: 28148501

Article Published Date : Jan 31, 2017

Study Type : Human Study

Additional Links

Substances : Folic Acid

Diseases : Hyperuricemia

Pharmacological Actions : Uricosuric Agents

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Environmental arsenic exposure reduces the effectiveness of folic acid supplementation in preventing myelomeningocele.Dec 31, 2014

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Folic acid effect on homocysteine, sortilin levels and glycemic control in type 2 diabetes mellitus patients.Jan 21, 2022

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Pubmed Data : Nutr Diabetes. 2022 06 22 ;12(1):33. Epub 2022 Jun 22. PMID: 35732620

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Pubmed Data : Sci Rep. 2016 Nov 23 ;6:37486. Epub 2016 Nov 23. PMID: 27876835

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Pubmed Data : Mediators Inflamm. 2016 ;2016:5912146. Epub 2016 Jun 2. PMID: 27340344

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Substances : Folic Acid , Vitamin B-12

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Folic acid supplementation reduced the risk of first stroke associated with elevated total cholesterol by 31% among hypertensive adults.Oct 31, 2016

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Pubmed Data : Stroke. 2016 Nov ;47(11):2805-2812. Epub 2016 Aug 11. PMID: 27729579

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Pubmed Data : J Clin Med. 2022 Dec 14 ;11(24). Epub 2022 Dec 14. PMID: 36556017

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Pubmed Data : J Nutr. 2003 Sep;133(9):2863-7. PMID: 12949378

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Pubmed Data : Arch Ital Urol Androl. 2019 Jul 2 ;91(2). Epub 2019 Jul 2. PMID: 31266276

Article Published Date : Jul 01, 2019

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Pubmed Data : Arch Intern Med. 2009 Feb 23;169(4):335-41. PMID: 19237716

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Ascorbic and folic acids have a beneficial role as antioxidants against thyroxin-induced testicular dysfunction in hyperthyroid rats.May 24, 2016

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Pubmed Data : Environ Sci Pollut Res Int. 2016 May 25. Epub 2016 May 25. PMID: 27221465

Article Published Date : May 24, 2016

Study Type : Animal Study

Additional Links

Substances : Folic Acid , Vitamin C

Diseases : Hyperthyroidism

Pharmacological Actions : Antioxidants

[+]

Boswellia sacra and folic acid attenuated the neurodegenerative effects of EMF in the hippocampus and cerebellum.Sep 30, 2017

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Pubmed Data : J Microsc Ultrastruct. 2017 Oct-Dec;5(4):216-224. Epub 2017 Sep 18. PMID: 30023257

Article Published Date : Sep 30, 2017

Study Type : Animal Study

Additional Links

Substances : Folic Acid , Frankincense

Diseases : Mobile Phone-Induced Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Radioprotective

Anti Therapeutic Actions : Mobile Phone Radiation

[+]

Curcumin could protect against the vascular side effects of methotrexate by preventing an increase in oxidative stress.Nov 15, 2015

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Pubmed Data : Can J Physiol Pharmacol. 2015 Nov 16:1-8. Epub 2015 Nov 16. PMID: 26571019

Article Published Date : Nov 15, 2015

Study Type : Animal Study

Additional Links

Substances : Curcumin, Folic Acid

Diseases : Drug Toxicity: Methotrexate, Endothelial Dysfunction, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation.Apr 30, 2010

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Pubmed Data : J Clin Invest. 2010 May ;120(5):1603-16. Epub 2010 Apr 26. PMID: 20424322

Article Published Date : Apr 30, 2010

Study Type : Animal Study

Additional Links

Substances : Folate, Folic Acid

Diseases : Brain Injury: Traumatic, Spinal Cord Injuries

Pharmacological Actions : Regenerative

Additional Keywords : DNA Methylation, Nerve Regeneration

[+]

Folate, zinc and antioxidants may prevent fertility problems. Mar 01, 2007

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Pubmed Data : Hum Reprod Update. 2007 Mar-Apr;13(2):163-74. Epub 2006 Nov 11. PMID: 17099205

Article Published Date : Mar 01, 2007

Study Type : Animal Study

Additional Links

Substances : Antioxidant formulas, Folic Acid , Zinc

Diseases : Infertility, Infertility: Female, Infertility: Male

Pharmacological Actions : Antioxidants, Apoptotic

[+]

Folic acid ameliorates alcohol-induced liver injury via gut-liver axis homeostasis.Dec 31, 2021

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Pubmed Data : Front Nutr. 2022 ;9:989311. Epub 2022 Oct 20. PMID: 36337656

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Pubmed Data : J Nutr Biochem. 2015 Dec ;26(12):1502-8. Epub 2015 Aug 8. PMID: 26345540

Article Published Date : Nov 30, 2015

Study Type : Transgenic Animal Study

Additional Links

Substances : Folic Acid

Diseases : Folic Acid/Folate Deficiency

Additional Keywords : Risk Factors

[+]

Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism.Nov 21, 2019

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Pubmed Data : Aging (Albany NY). 2019 Nov 22 ;11(22):10356-10373. Epub 2019 Nov 22. PMID: 31757935

Article Published Date : Nov 21, 2019

Study Type : Animal Study

Additional Links

Substances : Folic Acid

Diseases : Aging: Brain , Cognitive Decline/Dysfunction, Neurodegenerative Diseases

Pharmacological Actions : Neuroprotective Agents, Telomere Protective

[+]

Folic acid helps in improving the memory status by reducing oxidative stress and maintaining the integrity of neurons during aging.Jan 01, 2011

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Pubmed Data : Cell Mol Neurobiol. 2011 Jan;31(1):83-91. Epub 2010 Dec 18. PMID: 21170581

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Substances : Folic Acid

Diseases : Aging: Brain

Pharmacological Actions : Neuroprotective Agents

[+]

Folic acid improves developmental toxicity induced by aluminum sulphates.Feb 28, 2017

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Pubmed Data : Int J Mol Sci. 2017 May 5 ;18(5). Epub 2017 May 5. PMID: 28475147

Article Published Date : May 04, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Folic Acid

Diseases : Atherosclerosis

Pharmacological Actions : Anti-atherogenic

Additional Keywords : Gene Expression Regulation

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Pubmed Data : Mol Nutr Food Res. 2017 12 ;61(12). Epub 2017 Oct 26. PMID: 28921898

Article Published Date : Jan 11, 2017

Study Type : Animal Study

Additional Links

Substances : Folate, Folic Acid

Diseases : Anxiety Disorders, High Fat Diet, Prenatal Nutrition: Health of the Offspring

[+]

Melatonin plus folic acid treatment ameliorates reserpine-induced fibromyalgia.Dec 05, 2019

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[+]

The maternal combined supplementation of folic acid and Vitamin B(12) suppresses ethanol-induced developmental toxicity in mouse fetuses.Jul 01, 2006

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Pubmed Data : Reprod Toxicol. 2006 Jul;22(1):56-61. Epub 2006 Jan 24. PMID: 16439097

Article Published Date : Jul 01, 2006

Study Type : Animal Study

Additional Links

Substances : Folic Acid , Vitamin B-12

Diseases : Alcohol Toxicity , Prenatal Chemical Exposures

[+]

The toxic effects of BPA on testis might be minimized by folic acid treatment.Aug 05, 2018

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Pubmed Data : Biotech Histochem. 2018 Aug 6:1-10. Epub 2018 Aug 6. PMID: 30079777

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Pubmed Data : Clin Exp Pharmacol Physiol. 2018 Mar 6. Epub 2018 Mar 6. PMID: 29509296

Article Published Date : Mar 05, 2018

Study Type : Animal Study

Additional Links

Substances : Folic Acid , Vitamin B-12, Vitamin B-6

Diseases : Hyperhomocysteinemia

Pharmacological Actions : Cardioprotective

Additional Keywords : Cardioprotective, folic acid, Hyperhomocysteinemia, Vitamin B-12, Vitamin B-6

[+]

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Pharm Ther. 2021 Feb 9. Epub 2021 Feb 9. PMID: 33565138

Article Published Date : Feb 08, 2021

Study Type : Review

Additional Links

Substances : Folic Acid , Myo-inositol, Thiamine (B-1) , Vitamin B12, Vitamin B-6

Diseases : Diabetic Neuropathy

Pharmacological Actions : Antinoceceptive

[+]

Deficiency of dietary sources of methyl groups (e.g. methionine, choline, b12, folate, sam-e) reduce DNA methylation in the liver which leads to liver cancer.Aug 01, 2003

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Pubmed Data : Clin Chem Lab Med. 2003 Aug;41(8):1012-9. PMID: 12964806

Article Published Date : Aug 01, 2003

Study Type : In Vitro Study

Additional Links

Substances : Choline, Folic Acid , Methionine, SAMe (S-adenosylmethionine), Vitamin B-12

Diseases : Liver Cancer

[+]

Epigenetic factors in late-onset Alzheimer's disease by vitamins.Jan 13, 2019

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Pubmed Data : Int J Mol Sci. 2019 Jan 14 ;20(2). Epub 2019 Jan 14. PMID: 30646578

Article Published Date : Jan 13, 2019

Pubmed Data : Lancet. 2007 Jun 2;369(9576):1876-82. PMID: 17544768

Article Published Date : Jun 02, 2007

Study Type : Review

Additional Links

Substances : Folic Acid

Diseases : Stroke: Prevention

Additional Keywords : Meta-Analysis

[+]

Folic acid supplementation in patients taking SSRIs may reduce the risk of new onset diabetes via protection of normal beta cell function.Aug 31, 2014

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Pubmed Data : J Affect Disord. 2014 Sep ;166:6-13. Epub 2014 May 4. PMID: 25012404

Article Published Date : Aug 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Folic Acid

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Pancreato Protective Agents

Additional Keywords : Increased Risk, Risk Reduction

Problem Substances : Fluoxetine (trade name Prozac)

[+]

Click here to read the entire abstract

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Pubmed Data : Genes Nutr. 2017 ;12:14. Epub 2017 Jun 2. PMID: 28588742

Article Published Date : Dec 31, 2016

Study Type : Review

Additional Links

Substances : Folic Acid

Diseases : Folic Acid/Folate Deficiency, Leukemia

Pharmacological Actions : Chemopreventive

Additional Keywords : Chemopreventive, folic acid, Folic Acid/Folate Deficiency, leukemia, Risk Reduction

[+]

Negative effects of endocrine disruptor bisphenol A on ovarian granulosa cells and the protective role of folic acid.Jan 31, 2023

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Pubmed Data : Reproduction. 2023 Feb 1. Epub 2023 Feb 1. PMID: 36795652

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Pubmed Data : Pathogens. 2023 Mar 6 ;12(3). Epub 2023 Mar 6. PMID: 36986338

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Pubmed Data : Environ Toxicol. 2018 Sep ;33(9):988-1000. Epub 2018 Jul 4. PMID: 29972271

Article Published Date : Aug 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Folic Acid , Vitamin B-12

Diseases : Mitochondrial Dysfunction , Nicotine/Tobacco Toxicity

Pharmacological Actions : Antioxidants

[+]

These results demonstrat the radioprotective effect of folic acid supplementation on low dose ionizing radiation-induced genomic instability in vitro.Dec 31, 2015

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Pubmed Data : Indian J Exp Biol. 2016 08 ;54(8):537-43. PMID: 28577512

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Folic Acid

Diseases : DNA damage

Pharmacological Actions : Anti-Apoptotic, Radioprotective

Additional Keywords : Anti-Apoptotic, DNA damage, folic acid, Radioprotective

Anti Therapeutic Actions : Low Dose Ionizing Radiation

[+]

Vitamin supplementation shows promise for the treatment of migraines with aura and menstrual induced migraines.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Res Int. 2015;2015:469529. Epub 2015 Feb 28. PMID: 25815319

Article Published Date : Dec 31, 2014

Study Type : Review

View the Evidence: 188 Abstracts with Folic Acid Research

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Beneficial effects of folic acid on inflammatory markers in the patients with metabolic syndrome.Dec 27, 2022

Continuous use of folic acid during pregnancy may reduce the incidence of perinatal depressive symptoms.Jan 19, 2022

Dietary folate is associated with a significantly decreased risk of preterm birth.Dec 31, 2018

Folic acid supplementation during pregnancy significantly decreases the risk of congenital heart defects in newborns.Nov 08, 2016

Folic aicd combined with vitamin B6 and B12 treatment significantly reduced plasma homocysteine levelMay 31, 2015

Prenatal micronutrient supplementation, particularly iron/folic acid supplementation, was positively associated wtih aspects of intellectual functioning including working memory, inhibitory control, and fine motor functioning among offspring. Dec 22, 2010

This meta-analysis suggested that folic acid supplementation could significantly lower the serum CRP level.Dec 05, 2018

Vitamin B supplementation was effective in reducing serum homocysteine levels.Dec 31, 2016

5-methyltehydrofolate (folic acid) and vitamin B12 ameliorate red blood cell abnormalities in pediatric patients with Cystic Fibrosis. Jan 01, 2009

A case-control nutrigenomic study on the synergistic activity of folate and vitamin B12 in cervical cancer progression.Dec 31, 2011

A combination of nicotinamide 750 mg, zinc 25 mg, copper 1.5 mg, and folic acid 500 microg, marketed as Nicomide, appears to be an effective oral therapy for the treatment of acne vulgaris and rosacea. Jan 01, 2006

A dietary supplement containing melatonin, l-tryptophan, vitamin B6, folic acid, vitamin B12, methionine and betaine, is superior to omeprazole in treating GERD. Oct 01, 2006

A maternal daily intake of 400 µg folic acid alone significantly reduced the risks of infant low birth weight and small-for-gestational-age status.May 21, 2017

A multi-vitamin/nutrient formula has therapeutic value in early-stage Alzheimer's diease. Dec 01, 2008

A multi-vitamin/nutrient formula has therapeutic value in moderate-stage to later-stage Alzheimer's diease. Feb 01, 2009

Add-on supplementation with vitamin B12 improved glycaemic control and insulin resistance in patients with type 2 diabetes mellitus.Aug 31, 2020

Adequate dietary vitamin B9 and B12 intakes are significantly associated with a better cognitive performance.Dec 31, 2021

Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin. Jun 01, 2005

Air pollution exposure during the second trimester was significantly associated with gestational diabetes mellitus.Oct 09, 2020

Anemia in 85-year-old subjects is associated with folate deficiency and elevated homocysteine levels. Nov 10, 2008

B vitamins appear to slow cognitive and clinical decline in people with mild cognitive impairment, in particular in those with elevated homocysteine.Jul 21, 2011

B vitamins attenuate the epigenetic effects of ambient fine particles.Mar 12, 2017

Beneficial effects of pollen extract in association with vitamins for pain relief in patients affected by chronic prostatitis/chronic pelvic pain syndrome.Apr 23, 2013

Combined treatment with folic acid, vitamin B6, and vitamin B12 lowers homocysteine concentrations.May 17, 2018

D-chiro-inositol plus folic acid oral supplementation can improve metabolic control in overweight T1D patients.Dec 31, 2016

Decreased folic acid might possibly be one of the novel risk factors for erectile dysfunction.Nov 02, 2020

Dietary folate consumption as reflected in plasma folate and not supplementation with folic acid is inversely associated wtih prostate cancer risk. Mar 18, 2009

Dietary folate intake decreases the risk of endometrial cancer. Feb 01, 2007

Dietary folate is inversely associated with the risk of esophageal squamous-cell carcinoma.Mar 01, 2006

Effect of B vitamins supplementation on cardio-metabolic factors in patients with stable coronary artery disease.Dec 31, 2019

Elevated homocysteine levels associated with polymyalgia rheumatica and giant cell arteritis and the corticosteroid therapy used to treat these conditions may be attenuated with vitamin B12 and folic acid. Sep 01, 2003

Enalapril-folic acid therapy, compared with enalapril alone, can significantly reduce the magnitude of the increase of UA concentrations in hypertensive adultsJan 31, 2017

Environmental arsenic exposure reduces the effectiveness of folic acid supplementation in preventing myelomeningocele.Dec 31, 2014

Flower pollen extract in association with vitamins versus Serenoa repens in chronic prostatitis/chronic Pelvic pain syndrome.Dec 31, 2018

Folate improves the effect of metformin treatment on vascular endothelial function in women with polycystic ovary sydrome. Feb 01, 2010

Folate reduces plasma homocysteine and improves arterial function in patients with peripheral arterial disease. Sep 01, 2009

Folate supplementation for 8 weeks among women with PCOS had beneficial effects on metabolic profiles.Jun 30, 2014

Folate supplementation is protective against methotrexate induced side effects to the oral and gastrointestinal systems. Jan 01, 2000

Folate, riboflavin, thiamin and vitamin b12 protect against premalignant cervical lesions.Nov 01, 2003

Folic acid and vitamin B12 as biomarkers of morbidity and mortality in patients with septic shock.Feb 13, 2022

Folic acid appears to prevent and/or reverse precancerous lesions associated with gastritis. Jan 01, 2003

Folic acid deficiency may play a key role in neurodegenerative disorders. Jun 15, 2007

Folic acid deficiency should be regarded as an independent risk factor for arteriogenic erectile dysfunction.Dec 31, 2022

Folic acid effect on homocysteine, sortilin levels and glycemic control in type 2 diabetes mellitus patients.Jan 21, 2022

Folic acid may have a protective effect against cell proliferation in patients with ulcerative colitis.Jun 01, 1997

Folic acid may have a therapeutic effect in treating viral hepatitis.Jul 01, 1999

Folic acid may help with erectile dysfunction.Aug 24, 2015

Folic acid supplement in subjects with mild cognitive impairment can improve cognitive performance and reduce peripheral inflammatory levels.Nov 22, 2016

Folic acid supplement use during pregnancy is associated with improved neurodevelopment in children. May 01, 2009

Folic acid supplementation in early pregnancy, aimed to prevent neural tube defects, may also reduce mental health problems in children.Nov 01, 2003

Folic acid supplementation lowers blood arsenic concentrations. Oct 01, 2007

Folic acid supplementation may have a certain role in the treatment of children with autism.Jun 06, 2016

Folic acid supplementation mitigates Alzheimer's disease by reducing inflammation.Dec 31, 2015

Folic acid supplementation reduced the risk of first stroke associated with elevated total cholesterol by 31% among hypertensive adults.Oct 31, 2016

Folic acid supplementation reduces hypertensive disorders during pregnancy. Jan 01, 2009

Folic acid supplementation results in significant intima media thickness reduction after 18 months in patients with at least one cardiovascular risk.Feb 06, 2009

Folic acid treatment in TBI patients has the potential for preventing and treating hospital acquired pneumonia.Dec 13, 2022

High dosage of folic acid supplement from 3 months before pregnancy until the entire pregnancy reduces the recurrent pre-eclampsia.Jan 13, 2020

High dose folic acid supplementation is associated with a significant reduction in the recurrrence of colon cancers. Jul 28, 2008

High intake of dietary folate was associated with an overall decrease in bladder cancer risk.Jan 01, 2005

Higher consumption of folate may contribute to the prevention of peripheral arterial disease. Sep 01, 2003

Homocysteine levels in the tear fluid and plasma of patients with primary open-angle glaucoma is often elevated, indicating that inadequate vitamin b levels (e.g. b6, b12, and folate) may contribute to the disease.Jan 01, 2008

Homocysteine levels may be elevated in obstructive sleep apnea. Sep 01, 2001

It is possible that cervical dysplasia is caused by a derangement in folate metabolism or folate deficiency, and may be corrected through supplementation. Jan 01, 1982

L-arginine, folic acid, B6 and B12 may have therapeutic benefit in Buerger's disease. Oct 01, 2006

Low intake of folate, and b2, potassium, iron and vitamin A of plant origin, increase the risk for ischemic stroke.Dec 01, 2008

Low levels of serum folate were correlated with an increased severity of laryngeal squamous cell carcinoma.Nov 30, 2016

Lowering homocysteine with folic acids, B-6 and B-12 may have a therapeutic effect on migraine headaches. Jun 01, 2009

Moderate consumption of riboflavin may be protective against postpartum depression.Jul 31, 2000

Multi-nutrient supplementation improved cognition and mobility in able older females at clinically relevant levels.Jan 31, 2016

Myo-inositol plus folic acid has a beneficial effect in improving ovarian function in women with oligomenorrhea and polycystic ovaries. Sep 01, 2007

ncreased folate and vitamin B6 intakes seem to reduce homocysteine concentrations among transplant recipients with normal renal function, and could contribute to reducing the risk of chronic allograft dysfunction development.Mar 01, 1996

Folic Acid

View the Evidence:
188 Abstracts with Folic Acid Research