Formononetin

Name	AC	CK
Inflammation	12	19
Breast Cancer	7	10
Hyperglycemia	1	10
Alzheimer's Disease	7	9
Diabetes Mellitus: Type 2	5	9
Diabetic Nephropathy	4	8
Lipopolysaccharide-Induced Toxicity	5	8
Osteosarcoma	5	8
Oxidative Stress	5	8
Osteoarthritis	3	7
Brain Injury: Traumatic	3	6
Breast Cancer: Triple Negative	5	6
Multiple Myeloma	3	6
Brain Inflammation	3	5
Cerebral Ischemia	3	5
Cancers: All	3	4
Cancers: Drug Resistant	4	4
Cervical Cancer	4	4
Chemotherapy-Induced Kidney Damage	2	4
Chronic Kidney Disease (CKD)	2	4
Gastric Ulcer	2	4
Lung Injury: Acute	2	4
Prostate Cancer	4	4
Spinal Cord Injuries	3	4
Allergies	3	3
Bone Diseases	1	3
Chemotherapy-Induced Toxicity: Cisplatin	2	3
Depression	2	3
Endometriosis	1	3
Endothelial Dysfunction	2	3
Glioma	3	3
Myocardial Ischemia	2	3
Stroke: Ischemic	2	3
Wound Healing	2	3
Anxiety Disorders	1	2
Asthma	1	2
Atherosclerosis	1	2
Cancer Metastasis	2	2
Carcinoma: Non-Small-Cell Lung	2	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Colitis	1	2
Diabetes Mellitus: Type 1	1	2
Diabetes: Cognitive Dysfunction	1	2
Diabetes: Oxidative Stress	1	2
Diabetic Glomerular Hypertrophy	1	2
Diabetic Neuropathy	1	2
Dyslipidemias	1	2
Fractures: Bone	1	2
Gliomas	1	2
HIV Protease Inhibitor Ritonavir Toxicity	1	2
Hair Loss	1	2
Head and Neck Cancer	1	2
Helicobacter Pylori Infection	1	2
Hepatitis: Lectin-Induced (concanavalin)	1	2
High Fat Diet	1	2
Hydrogen Peroxide Induced Toxicity	2	2
Hypertension	1	2
Hypertension: Pulmonary	1	2
Hypothyroidism	1	2
Hypoxia	1	2
Insulin Resistance	1	2
Kidney Fibrosis	1	2
Liver Damage: Drug-Induced	1	2
Low Testosterone	1	2
Lymphoma	1	2
Mastitis	1	2
Memory Disorders	1	2
Muscle Atrophy	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Osteoporosis	1	2
Ovarian Cancer	2	2
Pain	1	2
Pancreatitis	1	2
Squamous cell carcinoma	1	2
Traumatic Brain Injury	2	2
Aging: Heart	1	1
Anxiety	1	1
Atopic Dermatitis	1	1
Bladder Cancer	1	1
Candida Infection	1	1
Chemotherapy-Induced Toxicity: Oxaliplatin	1	1
Chemotherapy-Induced Toxicity: Peripheral Neuropathy	1	1
Colon Cancer	1	1
Colorectal Cancer	1	1
Coronavirus Infection	1	1
Coxsackievirus Infections	1	1
Dementia	1	1
Diabetic Retinopathy	1	1
Drug-Induced Toxicity: Methotrexate	1	1
Enterovirus: Type 71	1	1
Esophageal Cancer	1	1
Gastric Cancer	1	1
Glioblastoma	1	1
Hypoxia: Brain	1	1
Ischemia	1	1
Liver Cancer	1	1
Liver Damage	1	1
Lung Cancer	1	1
Nasopharyngeal Cancer	1	1
Neurodegenerative Diseases	1	1
Obesity	1	1

Name	AC	CK
Anti-Inflammatory Agents	37	63
Antiproliferative	33	43
Apoptotic	24	30
Antioxidants	17	29
Tumor Necrosis Factor (TNF) Alpha Inhibitor	14	23
Hypoglycemic Agents	8	22
NF-kappaB Inhibitor	11	21
Neuroprotective Agents	14	21
Interleukin-1 beta downregulation	11	20
Interleukin-6 Downregulation	11	19
Renoprotective	11	19
Nrf2 activation	10	16
Anti-Apoptotic	9	15
Heme oxygenase-1 up-regulation	7	13
SIRT1 Activator	7	12
Cyclooxygenase 2 Inhibitors	7	10
MicroRNA modulator	8	10
Cell cycle arrest	7	9
Bcl-2 protein down-regulation	5	8
Anti-metastatic	7	7
Chemosensitizer	5	7
Osteoprotective	3	7
Chemoprotective Agents	4	6
Chemotherapeutic	4	6
Matrix metalloproteinase-2 (MMP-2) inhibitor	5	6
Matrix metalloproteinase-9 (MMP-9) inhibitor	5	6
Antineoplastic Agents	5	5
Hepatoprotective	3	5
Superoxide Dismutase Up-regulation	3	5
Angiogenesis Inducing Agents	2	4
Anti-Fibrotic	2	4
Anti-Ulcer Agents	2	4
Gastroprotective	2	4
Hypolipidemic	2	4
Cardioprotective	2	3
Chemopreventive	3	3
Malondialdehyde Down-regulation	2	3
Postaglandin PGE2 downregulation	2	3
STAT3 Inhibitor	2	3
Angiogenesis Inhibitors	1	2
Anti-Angiogenic	1	2
Anti-Anxiety Agents	1	2
Antidepressive Agents	1	2
Antihypertensive Agents	1	2
Antinoceceptive	1	2
Antiviral Agents	2	2
Brain-derived neurotrophic factor modulator	1	2
Insulin Sensitizers	1	2
Interleukin-10 upregulation	1	2
Pancreato Protective Agents	1	2
Secretagogue	1	2
Steroidogenesis	1	2
Vascular Endothelial Growth Factor Inhibitors	2	2
Vasodilator Agents	1	2
Anti-Allergic Agents	1	1
Anticarcinogenic Agents	1	1
Antifungal Agents	1	1
Antimicrobial	1	1
Autophagy Inhibitors	1	1
Cyclin D1 Down-Regulation	1	1
Histamine down-regulation	1	1
Histone deacetylase inhibitor	1	1
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	1
Immunomodulatory	1	1

[+]

Effects of isoflavone-rich red clover extract on blood glucose level.Mar 31, 2021

Click here to read the entire abstract

Pubmed Data : J Food Sci. 2021 Apr ;86(4):1393-1399. Epub 2021 Mar 24. PMID: 33761143

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2021 ;16(1):e0245050. Epub 2021 Jan 7. PMID: 33411783

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Formononetin

Diseases : Hypoxia, Lung Injury: Acute

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

[+]

Renoprotective effect of formononetin by suppressing Smad3 expression in Db/Db mice.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Planta Med. 2016 Jan ;82(1-2):65-9. Epub 2016 Jan 12. PMID: 26756818

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2009 Nov ;9(12):1357-65. Epub 2009 Aug 17. PMID: 19695348

Article Published Date : Oct 31, 2009

Study Type : Animal Study

Additional Links

Substances : Formononetin

Diseases : Fractures: Bone, Wound Healing

Pharmacological Actions : Angiogenesis Inducing Agents

Additional Keywords : Phytotherapy, Plant Extracts

[+]

This study has identified that calycosin and formononetin can increase the treatment effect of temozolomide.Oct 04, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : J Nutr Biochem. 2021 Nov 5:108899. Epub 2021 Nov 5. PMID: 34748924

Article Published Date : Nov 04, 2021

Study Type : In Vitro Study

Additional Links

Substances : Formononetin

Diseases : Cervical Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemopreventive

[+]

Formononetin reshapes the gut microbiota, prevents progression of obesity and improves host metabolism.Nov 24, 2021

Formononetin: A pathway to protect neurons. Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biol Pharm Bull. 2018 Aug 1 ;41(8):1194-1202. Epub 2018 May 29. PMID: 29848900

Article Published Date : Jul 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Formononetin

Diseases : Glioma

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative , Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

Additional Keywords : Chemotherapeutic Synergy: Temozolomide

[+]

The mechanism of formononetin/calycosin compound optimizing the effects of temozolomide on C6 malignant glioma.Aug 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2022 Sep ;153:113418. Epub 2022 Jul 22. PMID: 36076540

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Horm Metab Res. 2014 Oct ;46(11):753-60. Epub 2014 Jun 30. PMID: 24977660

Article Published Date : Sep 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Formononetin

Diseases : Breast Cancer, Breast Cancer: Triple Negative , Cancer Metastasis

Pharmacological Actions : Anti-metastatic, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

This is the first report of the presence of potent cyclooxygenase-2 inhibitors in Trifolium pratense L. extracts.Feb 28, 2019

Click here to read the entire abstract

Pubmed Data : J Sep Sci. 2019 Mar ;42(6):1133-1143. Epub 2019 Feb 25. PMID: 30620132

Article Published Date : Feb 28, 2019

Study Type : In Vitro Study

Additional Links

Substances : Biochanin A, Daidzein, Formononetin, Genistein, Isoflavones, Red Clover

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors

Additional Keywords : Plant Extracts

Formononetin jQuery(function ($) { $(".node-field-image").click(function () { $(".node-field-image").toggleClass("open"); }); $(".node.topic>.colfull").click(function () { $(".node.topic>.colfull").toggleClass("open"); }); })

Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 122 Abstracts with Formononetin Research

Limited to Members Only

Currently Available Sorting Options

Effects of isoflavone-rich red clover extract on blood glucose level.Mar 31, 2021

Formononetin improves the inflammatory response and bone destruction in knee joint lesions.Mar 31, 2023

Formononetin inhibits progression of endometriosis.Jun 29, 2023

A hydroalcoholic extract of red propolis presented anti-nociceptive action on inflammatory and neurogenic pain without motor side effects.Jul 16, 2015

Anti-colorectal cancer mechanisms of formononetin identified by network pharmacological approach.Apr 30, 2019

Anxiolytic effects of Formononetin in an inflammatory pain model.Jan 07, 2019

Formononetin activates the Nrf2/ARE signaling pathway Via Sirt1 to improve diabetic renal fibrosis.Dec 31, 2019

Formononetin administration ameliorates dextran sulfate sodium-induced acute colitis.Dec 31, 2017

Formononetin alleviates acute pancreatitis by reducing oxidative stress and modulating intestinal barrier.Jun 26, 2023

Formononetin alleviates chronic kidney disease by impeding ferroptosis-associated fibrosis.Feb 14, 2023

Formononetin alleviates hepatic steatosis by facilitating TFEB-mediated lysosome biogenesis and lipophagy.Jul 24, 2019

Formononetin ameliorates diabetic neuropathy.May 26, 2020

Formononetin ameliorates muscle atrophy.Jan 05, 2021

Formononetin ameliorates myocardial ischemia/reperfusion injury. May 06, 2020

Formononetin and biochanin A protects against ritonavir induced hepatotoxicity.Nov 14, 2018

Formononetin as a promising agent for preventing gentamicin-induced organ damage.Dec 31, 2021

Formononetin attenuates atherosclerosis via regulating interaction between KLF4 and SRA in apoE-/- mice.Dec 31, 2019

Formononetin attenuates renal tubular injury and mitochondrial damage in diabetic nephropathy.Dec 31, 2021

Formononetin could be a promising agent for the treatment of autoimmune hepatitis.Mar 31, 2021

Formononetin could improve the cognitive function by inhibiting neuroinflammation.Aug 06, 2019

Formononetin enhances bone regeneration in a mouse model of cortical bone defect.May 31, 2017

Formononetin enhances the tumoricidal effect of everolimus by inhibiting the activity of Akt.Dec 31, 2018

Formononetin exhibits anti-hyperglycemic activity in alloxan-induced type 1 diabetic mice.Dec 31, 2016

Formononetin had the therapeutic effects in attenuating airway inflammation and oxidative stress in asthma.Dec 31, 2019

Formononetin has a protective effect on lipopolysaccharide-induced acute lung injury in mice.Nov 30, 2013

Formononetin has inhibitory effects on the proliferation of U2SO cells.Dec 31, 2014

Formononetin induces vasorelaxation in rat thoracic aorta via regulation of the PI3K/PTEN/Akt signaling pathway.Dec 31, 2017

Formononetin inhibits IL-1β-induced inflammation in human chondrocytes and slows the progression of osteoarthritis.Oct 24, 2022

Formononetin inhibits inflammation and promotes gastric mucosal angiogenesis in gastric ulcer.Oct 25, 2020

Formononetin inhibits microglial inflammatory response and contributes to spinal cord injury repair.Oct 31, 2023

Formononetin is an effective molecule to control nephropathy in type 2 diabetes mellitus.Feb 14, 2019

Formononetin may be a promising candidate for the treatment and prevention of osteoarthritis.Jul 31, 2019

Formononetin mediates neuroprotection against cerebral ischemia/reperfusion.Sep 14, 2014

Formononetin mediates the promising anti-traumatic brain injury effects against neurocyte damage.Mar 14, 2014

Formononetin prevents ovariectomy-induced bone loss in rats.Mar 31, 2010

Formononetin protects against cisplatin‑induced acute kidney injury.Nov 30, 2020

Formononetin protects against inflammation associated with cerebral ischemia-reperfusion injury.Mar 23, 2022

Formononetin protects against ox-LDL-induced endothelial dysfunction.Nov 30, 2021

Formononetin protects LPS-induced mastitis through suppressing inflammation and enhancing blood-milk barrier integrity.Dec 31, 2021

Formononetin recovered injured nerve functions after ischemic stroke.Feb 16, 2020

Formononetin regulates multiple oncogenic signalling cascades and enhances sensitivity to bortezomib in a multiple myeloma mouse model.Jul 06, 2019

Formononetin treatment reduces insulin resistance and attenuate hyperglycemia in type 2 diabetes.Dec 31, 2017

Formononetin, a novel FGFR2 inhibitor, potently inhibits angiogenesis and tumor growth in preclinical models.Dec 28, 2015

Hydroalcoholic extracts of red propolis and formononetin are gastroprotective in acute ulcer models.Sep 25, 2020

In vitro and in vivo studies of antiosteosarcoma activities of formononetin.Jul 31, 2019

Increased miR-155 and heme oxygenase-1 expression is involved in the protective effects of formononetin in traumatic brain injury.Dec 31, 2016

Inhibitory effects of formononetin on the monocrotaline‑induced pulmonary arterial hypertension.Feb 29, 2020

Neuroprotective effect of formononetin against traumatic brain injury.Sep 30, 2018

Neuroprotective effect of formononetin in ameliorating learning and memory impairment in mouse model of Alzheimer's disease.Dec 31, 2017

Phytoestrogens can stimulate testosterone synthesis during puberty in male goats by increasing the secretion of T3; a hormone known to stimulate Leydig cell steroidogenesis.Dec 10, 2009

red clover extract and biochanin A or formononetin significantly ameliorate the lipid profiles of STZ-diabetic mice.May 31, 2012

Reduction of hyperoxic acute lung injury in mice by formononetin.Dec 31, 2020

Renoprotective effect of formononetin by suppressing Smad3 expression in Db/Db mice.Dec 31, 2019

The anti-inflammatory effects of formononetin and ononin on lipopolysaccharide-induced zebrafish models based on lipidomics and targeted transcriptomics.Jan 24, 2019

The antidepressant-like effect of formononetin on chronic corticosterone-treated mice.May 14, 2022

The oral administration of formononetin decelerated tumor growth through.Jan 31, 2020

The protective effect of formononetin on cognitive impairment in streptozotocin-induced diabetic mice.Sep 30, 2018

These findings demonstrate that formononetin exerted the hair regrowth effect on hair loss.Dec 31, 2015

These findings indicate that formononetin exhibits significant anti-cancer effects in multiple myeloma.Dec 31, 2017

These results indicate the use of formononetin in the prevention of breast cancer carcinogenesis.Aug 31, 2011

These results suggest that formononetin promotes early fracture healing through angiogenesis activation in the early stage of fracture repair.Oct 31, 2009

This study has identified that calycosin and formononetin can increase the treatment effect of temozolomide.Oct 04, 2019

A review of formononetin and its anticancer potentials and mechanisms.Dec 31, 2018

Flavonoids synergistically enhance the anti-glioblastoma effects of chemotherapeutic drugs.Jan 06, 2021

Focus on formononetin: anticancer potential and molecular targets.Apr 30, 2019

Focusing on formononetin: recent perspectives for its neuroprotective potentials.Dec 31, 2021

Formononetin ameliorated mast cell-mediated allergic inflammation.Nov 30, 2017

Formononetin ameliorates high glucose‑induced endothelial dysfunction.Aug 31, 2019

Formononetin ameliorates IL‑13‑induced inflammation and mucus formation in human nasal epithelial cells.Nov 30, 2021

Formononetin ameliorates oxaliplatin-induced peripheral neuropathy.Aug 31, 2020

Formononetin ameliorates the drug resistance of Taxol resistant triple negative breast cancer by inhibiting autophagy.Dec 31, 2020

Formononetin ameliorates the LPS-induced inflammatory response and apoptosis of neuronal cells.Oct 16, 2023

Formononetin

View the Evidence:
122 Abstracts with Formononetin Research