Fucoidan

Name	AC	CK
Cancers: All	22	52
Inflammation	23	52
Liver Cancer	18	32
Oxidative Stress	19	31
Obesity	13	30
Lung Cancer	15	29
Diabetes Mellitus: Type 2	16	28
Breast Cancer	18	23
Asthma	3	22
Lipopolysaccharide-Induced Toxicity	15	22
Chronic Pain	1	21
Atherosclerosis	10	18
Neurodegenerative Diseases	7	18
Colon Cancer	13	17
Nonalcoholic fatty liver disease (NAFLD)	5	17
Atopic Dermatitis	4	16
Colorectal Cancer	6	15
Diabetic Nephropathy	8	15
Insulin Resistance	4	15
Liver Cirrhosis	3	14
Alzheimer's Disease	8	13
Coronavirus Infection	9	13
Helicobacter Pylori Infection	3	13
Hyperlipidemia	7	13
Parkinson's Disease	8	13
Athletic Performance	2	12
Brain: Oxidative Stress	2	12
Immune Dysregulation: TH1/TH2 imbalance	2	12
Chemically-Induced Liver Damage	6	11
Colorectal Adenomas	1	10
Gastritis	1	10
Hypertension	1	10
T-lymphotropic virus type-1 Infection: Human	1	10
Ultraviolet Radiation Induced Damage	4	10
Alcohol Toxicity	4	9
Ischemia	6	9
Kidney Fibrosis	4	9
Chemotherapy-Induced Toxicity: Cisplatin	6	8
Diabetic Complications	4	8
Oral Cancer	6	8
Ulcerative Colitis	4	8
Breast Cancer: Triple Negative	5	7
Melanoma	7	7
Alcoholic Liver Disease	3	6
Cerebral Ischemia	3	6
Chemotherapy-Induced Toxicity: Doxorubicin	4	6
Chronic Kidney Disease (CKD)	3	6
Cognitive Decline/Dysfunction	3	6
Liver Damage	3	6
Liver Injury: Ischemia/reperfusion	3	6
Osteoarthritis	4	6
Osteoporosis	4	6
Thrombosis	4	6
Aspirin-Induced Toxicity	3	5
Bladder Cancer	4	5
Dyslipidemias	3	5
Fibrosis	3	5
Gastric Ulcer	3	5
HIV Infections	4	5
Prostate Cancer	4	5
Pulmonary Fibrosis	2	5
Radiation Induced Illness	3	5
Acetaminophen (Tylenol) Toxicity	2	4
Air Pollution Linked Toxicity	2	4
Cancer Metastasis	3	4
Endotoxemia	2	4
High Fat Diet	2	4
Hydrogen Peroxide Induced Toxicity	4	4
Hyperalgesia	2	4
Hyperglycemia	2	4
Hyperoxia	2	4
Inflammatory Bowel Diseases	2	4
Kidney Damage	2	4
Lipid Peroxidation	2	4
Myocardial Infarction	2	4
Neuropathic Pain	2	4
Norovirus	2	4
Osteosarcoma	4	4
Wound Healing	3	4
Brain: Microglial Activation	3	3
Cervical Cancer	3	3
Chemotherapy-Induced Kidney Damage	2	3
Chemotherapy-Induced Toxicity: Cyclophosphamide	2	3
Dengue	3	3
Gastric Cancer	3	3
Heart Failure	1	3
Hypoxia	2	3
Liver Fibrosis	2	3
Lung Cancer: Metastatic	2	3
Multiple Myeloma	2	3
Acute Myeloid Leukemia	2	2
Aging: Heart	1	2
Allergies	2	2
Aneurysm: Aortic	1	2
Aortic Aneurysm	1	2
Aortic Plaques	1	2
Arteriosclerosis	1	2
Bone Destructive Diseases: Over-Active Osteoclasts	1	2
Bone Fractures	1	2
Breast Cancer: Chemically-Induced	1	2
Cachexia: Chemotherapy Induced	1	2
Cancers: Canine	1	2
Carcinoma: Non-Small-Cell Lung	1	2
Cardiac Hypertrophy	1	2
Cardiomyopathy	1	2
Cartilage Diseases	1	2
Cartilage Injury	1	2
Coronavirus Disease (Covid-19)	2	2
Cytomegalovirus Infections	1	2
DNA damage	1	2
Depression	1	2
Depression: Restraint Stress Related	1	2
Diabetes Mellitus: Type 1	1	2
Diabetes Mellitus: Type 1: Prevention	1	2
Diabetes Mellitus: Type 2: Prevention	1	2
Dopamine Deficiency	1	2
Drug-Induced Toxicity: Gastrointestinal	1	2
Dry Eye Syndromes	1	2
Dyspepsia	1	2
Electric Injuries	1	2
Electrical Burn Injury	1	2
Endometriosis	1	2
Endothelial Dysfunction	1	2
Enterovirus	1	2
Escherichia coli Infections	2	2
Fibrosarcoma	2	2
Food Allergies	1	2
Glioma	2	2
HSV-1	1	2
HSV-2	1	2
Heart Disease: Ischemic	2	2
Hepatitis B	2	2
Hepatitis: Lectin-Induced (concanavalin)	1	2
Herpes Simplex Virus Type 1	1	2
Herpes Simplex Virus Type 2	1	2
Hip Fracture	1	2
Histamine: Elevated	1	2
Hypersensitivity: Type I	2	2
Hyperuricemia	1	2
Inflammation: Brain	1	2
Inflammation: Neutrophil-Mediated	1	2
Intima Media Thickening	1	2
Iron Overload	1	2
Ischemic Heart Disease	2	2
Kidney Damage: Chemically-Induced	1	2
Leukemia: Acute promyelocytic leukemia	1	2
Liver Damage: Aflatoxin-Induced	1	2
Liver Disease	2	2
Lung Damage	1	2
Lymphoma: B-Cell	1	2
Macular Degeneration	2	2
Malaria	1	2
Metabolic Diseases	1	2
Multiple Sclerosis	1	2
Myocardial Fibrosis	1	2
Myocardial Infarction: Prevention	1	2
Myocardial Ischemia	1	2
Myocarditis: Autoimmune	1	2
Organ Transplantation: Aorta	1	2
Pancreatic Diseases	1	2
Periodontitis	1	2
Pesticide Toxicity	1	2
Pesticide-Induced Toxicity: Organophosphates	1	2
Pneumonitis	1	2
Proliferative Vitreoretinopathy (PVR)	1	2
Pseudomonas aeruginosa	1	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Radiotherapy	1	2
Restenosis	1	2
Sarcomas	2	2
Squamous cell carcinoma	2	2
Surgical Adhseions	1	2
Traumatic Brain Injury	1	2
Ulcers	1	2
Vibrio Alginolyticus Infection	1	2
Weight Problems	2	2
Anaphylaxis	1	1
Animal Diseases: Canine Distemper Virus	1	1
Autoimmune Diseases	1	1
Avian Influenza	1	1
Bacterial Infections	1	1
Benzo[a]pyrene-induced Toxicity	1	1
Brain Inflammation	1	1
Cancers: Drug Resistant	1	1
Cardiovascular Diseases	1	1
Central Nervous System Diseases	1	1
Cholangiocarcinoma	1	1
Clotting	1	1
Colon Cancer: Prevention	1	1
Diabetes: Cognitive Dysfunction	1	1
Diesel Exhaust Particle Toxicity	1	1
Dysbiosis	1	1
Gastroenteritis	1	1
Hair Loss: Drug-Induced	1	1
Head and Neck Cancer	1	1
Hepatic Steatosis	1	1
Hepatoma	1	1
Hypertension: Pulmonary	1	1
Influenza A	1	1
Ischemia: Myocardial	1	1
Kidney Diseases	1	1
Leiomyoma	1	1
Leishmaniasis	1	1
Liver Damage: Drug-Induced	1	1
Low Immune Function: Natural Killer Cells	1	1
Lymphoma	1	1
Metabolic Syndrome X	1	1
Mitochondrial Diseases	1	1
Mycoplasma Infections	1	1
Neomycin Toxicity	1	1
Neurological Conditions	1	1
Newcastle Disease Virus	1	1
Pancreatic Cancer	1	1
Parainfluenza Virus Infections	1	1
Parkinsonian Disorders	1	1
Pigmentation Disorders	1	1
Promyelocytic leukemia	1	1
Radiation	1	1
Rheumatoid Arthritis	1	1
Rotavirus Infections	1	1
Salmonella Infections	1	1
Sepsis	1	1
Skin Cancer	1	1
Skin Diseases: Inflammatory	1	1
Staphylococcus aureus infection	1	1
Thyroid Cancer	1	1
Tuberculosis	1	1
Tumors	1	1
Wound Healing: Delayed	1	1

Name	AC	CK
Anti-Inflammatory Agents	75	168
Antioxidants	57	100
Antiproliferative	61	91
Apoptotic	67	74
Immunomodulatory	20	63
Neuroprotective Agents	29	62
Antineoplastic Agents	43	52
Hepatoprotective	22	50
Gastrointestinal Agents	17	49
Anti-metastatic	22	47
Interleukin-6 Downregulation	22	47
Tumor Necrosis Factor (TNF) Alpha Inhibitor	24	43
Antiviral Agents	27	41
Chemotherapeutic	13	33
Hypolipidemic	14	32
Interleukin-1 beta downregulation	18	29
NF-kappaB Inhibitor	17	27
Renoprotective	15	26
Analgesics	3	25
Cardioprotective	13	24
Anti-Apoptotic	15	23
Anti-Bacterial Agents	11	22
Chemosensitizer	10	21
Chemopreventive	13	20
Superoxide Dismutase Up-regulation	7	19
Anti-Fibrotic	9	18
Hypoglycemic Agents	10	18
Cell cycle arrest	16	17
Nrf2 activation	11	17
Chemoprotective Agents	11	15
MicroRNA modulator	5	15
Interleukin-8 downregulation	3	13
Antihypertensive Agents	3	12
Brain-derived neurotrophic factor modulator	2	12
Interferon Gamma Reducer	2	12
Angiogenesis Inhibitors	9	11
Anti-Angiogenic	5	11
Antimicrobial	1	10
Interleukin-4 downregulation	1	10
Photoprotective	4	10
Gastroprotective	5	9
Heme oxygenase-1 up-regulation	6	9
Interleukin-10 upregulation	4	8
Matrix metalloproteinase-2 (MMP-2) inhibitor	5	8
Cyclooxygenase 2 Inhibitors	4	7
Matrix metalloproteinase-9 (MMP-9) inhibitor	5	7
Angiogenesis Inducing Agents	4	6
Anti-Ulcer Agents	3	6
Anti-atherogenic	3	6
Bcl-2 protein down-regulation	6	6
Immunostimulatory	3	6
Pancreato Protective Agents	3	6
Radioprotective	4	6
Anti-Allergic Agents	4	5
Anti-Tumor	3	5
Malondialdehyde Down-regulation	3	5
Anti-Adipogenic	3	4
Anticarcinogenic Agents	3	4
Anticoagulants	4	4
Antidepressive Agents	2	4
Interleukin-18 down-regulation	2	4
Osteoprotective	3	4
Thrombolytic	2	4
Transforming growth factor beta (TGF-β) inhibitor	2	4
Vascular Endothelial Growth Factor Inhibitors	4	4
Autophagy Up-regulation	2	3
Insulin Sensitizers	2	3
Interleukin-1 alpha downregulation	1	3
Matrix metalloproteinase-1 (MMP-1) inhibitor	2	3
Osteogenic	2	3
Postaglandin PGE2 downregulation	1	3
SIRT1 Activator	1	3
Wnt/β-catenin pathway down-regulation	2	3
interleukin-13 down-regulation	2	3
Anti-Cachexic Agents	1	2
Anti-HIV Agents	2	2
Anticholesteremic Agents	1	2
Antinoceceptive	1	2
Antiparasitic Agents	1	2
Autophagy Inhibitors	1	2
Bax/Bcl2 Ratio: Decrease	1	2
Caspase-8 activation	2	2
Cyclooxygenase 1 Inhibitor	1	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Immunomodulatory: Innate Immunity Up-Regulation	1	2
Insulin-releasing	1	2
Neutrophil Activation: Down-Regulation	1	2
Neutrophil Rolling Inhibitor	1	2
Proteasome Inhibitors	1	2
Tumor Necrosis Factor (TNF) Alpha Enhancer	1	2
Tumor Suppressor Protein p53 Upregulation	2	2
Uricosuric Agents	1	2
Vascular Endothelial Growth Factor A Inhibitor	1	2
Vasoprotective	1	2
Acetylcholinesterase Inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Anti-Infective Agents	1	1
Anti-Platelet	1	1
Anti-thrombotic	1	1
Antifungal Agents	1	1
Caspase-3 Activation	1	1
Catalase Up-Regulation	1	1
Cytotoxic	1	1
Enzyme Inhibitors	1	1
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	1
Interleukin-2 Downregulation	1	1
Interleukin-5 downregulation	1	1
Leishmanicidal	1	1
Lipolytic	1	1
Matrix Metalloproteinases Inhibitors	1	1
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	1
Nitric Oxide Inhibitor	1	1
Prophylactic Agents	1	1
Radiosensitizer	1	1
Telomerase Inhibitor	1	1
Tyrosinase inhibitors	1	1

[+]

Fucoidan as a promising drug for pain treatment: systematic review and meta-analysis.Jun 23, 2024

Effects of L-selectin stimulation (via fucoidan) of the expression of chemokine receptor CXCR4 on NK cells of healthy donors and tumor patients.Apr 30, 2012

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Pubmed Data : Bull Exp Biol Med. 2012 May ;153(1):86-8. PMID: 22808501

Article Published Date : Apr 30, 2012

Study Type : Human Study

Additional Links

Substances : Fucoidan

[+]

Effects of oligo-fucoidan on the immune response, inflammatory status and pulmonary function in patients with asthma.Oct 27, 2022

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Pubmed Data : Sci Rep. 2022 Oct 28 ;12(1):18150. Epub 2022 Oct 28. PMID: 36307493

Article Published Date : Oct 27, 2022

Study Type : Human Study

Additional Links

Substances : Fucoidan

Diseases : Asthma

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interleukin-8 downregulation

[+]

Fermented Laminaria japonica supplementation may protect against progressive degeneration purportedly caused by reactive oxygen species.Dec 31, 2017

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[+]

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Pubmed Data : Burns. 2011 Nov ;37(7):1216-21. PMID: 21641115

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Pubmed Data : J Cardiovasc Pharmacol Ther. 2011 Mar ;16(1):79-86. Epub 2010 Dec 30. PMID: 21193680

Article Published Date : Feb 28, 2011

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Myocarditis: Autoimmune

[+]

"Suppression by fucoidan of liver fibrogenesis via the TGF-β/Smad pathway in protecting against oxidative stress."Dec 31, 2010

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Pubmed Data : Biosci Biotechnol Biochem. 2011 ;75(5):833-40. Epub 2011 May 20. PMID: 21597183

Article Published Date : Dec 31, 2010

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Liver Cirrhosis, Liver Fibrosis, Oxidative Stress

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

[+]

A combination of deep-sea water and fucoidan alleviates T2DM through modulation of gut microbiota and metabolic pathways.Mar 19, 2023

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Pubmed Data : Pharmaceuticals (Basel). 2023 Mar 20 ;16(3). Epub 2023 Mar 20. PMID: 36986561

Article Published Date : Mar 19, 2023

Study Type : Animal Study

Additional Links

Substances : Fucoidan, Water: Deep Sea

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Gastrointestinal Agents, Hypoglycemic Agents, Hypolipidemic, Insulin Sensitizers

[+]

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Pubmed Data : Int J Pharm. 2020 Jul 3 ;586:119597. Epub 2020 Jul 3. PMID: 32629067

Article Published Date : Jul 02, 2020

Study Type : Animal Study

Additional Links

Substances : Anthocyanins, Chokeberry, Fucoidan

Diseases : Cancers: All

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents

[+]

Anti-hyperlipidemic effect of fucoidan fractions prepared from Iceland brown Algae Ascophyllum nodosum.Aug 25, 2023

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Pubmed Data : Mar Drugs. 2023 Aug 26 ;21(9). Epub 2023 Aug 26. PMID: 37755081

Article Published Date : Aug 25, 2023

Study Type : Animal Study

Additional Links

Substances : Fucoidan, Seaweed: Brown

Diseases : Hyperlipidemia

Pharmacological Actions : Hypolipidemic

Additional Keywords : Natural Substances Versus Drugs

Problem Substances : Atorvastatin

[+]

Anti-metabolic syndrome effects of fucoidan from Fucus vesiculosus.Sep 11, 2019

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Pubmed Data : Nutr Res. 2023 Nov 17 ;122:1-18. Epub 2023 Nov 17. PMID: 38064857

Article Published Date : Nov 16, 2023

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Ulcerative Colitis

Pharmacological Actions : Autophagy Up-regulation, Gastrointestinal Agents

[+]

Fucoidan alleviates acetaminophen-induced hepatotoxicity.Dec 13, 2018

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Pubmed Data : Int J Mol Sci. 2018 Dec 14 ;19(12). Epub 2018 Dec 14. PMID: 30558169

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Pubmed Data : Oncotarget. 2014 Sep 15 ;5(17):7870-85. PMID: 25149540

Article Published Date : Sep 14, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Antiproliferative , Proteasome Inhibitors

[+]

Fucoidan could play a protective role in cerebral ischemia-reperfusion injury.Nov 24, 2016

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Pubmed Data : Biomol Ther (Seoul). 2016 Nov 25. Epub 2016 Nov 25. PMID: 27871155

Article Published Date : Nov 24, 2016

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Cerebral Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

Additional Keywords : Dose Response

[+]

Fucoidan could prevent the development of autoimmune diabetes.Dec 31, 2018

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Pubmed Data : Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID: 21084063

Article Published Date : Jan 31, 2011

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Pubmed Data : Carbohydr Polym. 2019 Nov 1 ;223:115034. Epub 2019 Jun 28. PMID: 31426965

Article Published Date : Oct 31, 2019

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Breast Cancer

Pharmacological Actions : Anti-Angiogenic, Chemopreventive

[+]

Fucoidan from Laminaria japonica ameliorates type 2 diabetes mellitus.Dec 21, 2022

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Pubmed Data : Foods. 2022 Dec 22 ;12(1). Epub 2022 Dec 22. PMID: 36613249

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Pubmed Data : J Agric Food Chem. 2024 May 1 ;72(17):9755-9767. Epub 2024 Apr 18. PMID: 38635872

Article Published Date : Apr 30, 2024

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Diabetic Nephropathy

Pharmacological Actions : Gastrointestinal Agents, Renoprotective

[+]

Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis in breast cancer.Mar 31, 2013

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Pubmed Data : J Pharmacol Sci. 2016 Mar 22. Epub 2016 Mar 22. PMID: 27094367

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Pubmed Data : Mol Med Rep. 2015 Sep ;12(3):4501-7. Epub 2015 Jun 23. PMID: 26130492

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Pubmed Data : J Med Food. 2021 Oct ;24(10):1058-1067. PMID: 34668763

Article Published Date : Sep 30, 2021

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : High Fat Diet, Obesity

Pharmacological Actions : Gastrointestinal Agents

Additional Keywords : Anti-Obesity Agents

[+]

Fucoidan protects against subacute diazinon-induced oxidative damage.Jan 20, 2020

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Pubmed Data : Environ Sci Pollut Res Int. 2020 Jan 21. Epub 2020 Jan 21. PMID: 31965500

[+]

Fucoidan-rich substances in E. cava could be a potential material for improving cognitive function.Oct 16, 2019

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Pubmed Data : Food Funct. 2022 Feb 7 ;13(3):1168-1179. Epub 2022 Feb 7. PMID: 35018932

Article Published Date : Feb 06, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, NF-kappaB Inhibitor, Renoprotective

[+]

Fucoidans from Pearsonothuria graeffei prevent obesity by regulating intestinal lipid metabolism and inflammation.Nov 06, 2022

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Pubmed Data : Food Funct. 2022 Nov 7. Epub 2022 Nov 7. PMID: 36342362

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Pubmed Data : J Sci Food Agric. 2021 Oct 24. Epub 2021 Oct 24. PMID: 34689333

Article Published Date : Oct 23, 2021

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Chemically-Induced Liver Damage, Chemotherapy-Induced Toxicity: Cyclophosphamide, Kidney Damage: Chemically-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Cyclophosphamide

[+]

Low molecular weight fucoidan alleviates cerebrovascular damage by promoting angiogenesis in type 2 diabetes mice.Jul 12, 2022

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Pubmed Data : Int J Biol Macromol. 2022 Jul 13 ;217:345-355. Epub 2022 Jul 13. PMID: 35841956

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Pubmed Data : Carbohydr Polym. 2021 Dec 1 ;273:118567. Epub 2021 Aug 19. PMID: 34560978

Article Published Date : Nov 30, 2021

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Interleukin-6 Downregulation, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Low molecular weight fucoidan can inhibit the fibrosis of diabetic kidneys by regulating the kidney lipid metabolism.Dec 31, 2020

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Pubmed Data : Planta Med. 2015 Oct ;81(15):1370-4. Epub 2015 Aug 19. PMID: 26287767

Article Published Date : Sep 30, 2015

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Ultraviolet Radiation Induced Damage

Therapeutic Actions : Sunlight exposure

Pharmacological Actions : Anti-Inflammatory Agents, Photoprotective

[+]

Mixture of phlorotannin and fucoidan from Ecklonia cava prevents the Aβ-induced cognitive decline.Jul 28, 2021

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Pubmed Data : J Biomed Sci. 2022 Sep 15 ;29(1):70. Epub 2022 Sep 15. PMID: 36109724

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Pubmed Data : PLoS One. 2015 ;10(6):e0128453. Epub 2015 Jun 17. PMID: 26083103

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Inflammatory Bowel Diseases, Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Pretreatment with fucoidan from fucus vesiculosus protected against ConA-induced acute liver injury.Dec 31, 2015

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Pubmed Data : PLoS One. 2016 ;11(4):e0152570. Epub 2016 Apr 1. PMID: 27035150

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Hepatitis: Lectin-Induced (concanavalin), Liver Damage

Pharmacological Actions : Anti-Apoptotic, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Concanavalin A

[+]

Probiotic-loaded calcium alginate/fucoidan hydrogels for promoting oral ulcer healing.Jul 30, 2023

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Pubmed Data : Int J Biol Macromol. 2023 Jul 31 ;244:125273. Epub 2023 Jun 9. PMID: 37301354

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Pubmed Data : Phytother Res. 2010 Jul ;24(7):1078-83. PMID: 20578121

Article Published Date : Jun 30, 2010

Study Type : Animal Study

Additional Links

Substances : Fucoidan

[+]

Sargassum fusiforme fucoidan ameliorates diet-induced obesity through enhancing thermogenesis of adipose tissues and modulating gut microbiota.Aug 31, 2022

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Pubmed Data : Int J Biol Macromol. 2022 Sep 1 ;216:728-740. Epub 2022 Jul 28. PMID: 35907465

The fucoidan from the brown seaweed Ascophyllum nodosum ameliorates atherosclerosis in apolipoprotein E-deficient mice.Jul 31, 2019

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Pubmed Data : Food Funct. 2019 Aug 1 ;10(8):5124-5139. Epub 2019 Jul 31. PMID: 31364648

Article Published Date : Jul 31, 2019

Study Type : Animal Study

Additional Links

Substances : Fucoidan, Seaweed: Brown

Diseases : Atherosclerosis, Hyperlipidemia

Pharmacological Actions : Anti-atherogenic

[+]

The regulatory effects of fucoidan and laminarin on functional dyspepsia mice induced by loperamide.Jul 16, 2023

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Pubmed Data : Food Funct. 2023 Jul 17 ;14(14):6513-6525. Epub 2023 Jul 17. PMID: 37377021

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Pubmed Data : Top Companion Anim Med. 2021 Dec 2:100616. Epub 2021 Dec 2. PMID: 34864255

These results demonstrate that fucoidan prevents endotoxin-induced damage in a mouse model of endotoxemia.Jan 30, 2014

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Pubmed Data : Mar Drugs. 2014 Jan 31 ;12(2):886-98. Epub 2014 Jan 31. PMID: 24492521

Article Published Date : Jan 30, 2014

Study Type : Animal Study

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Substances : Fucoidan

Diseases : Endotoxemia, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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These results indicate that fucoidan is a potential preventive and therapeutic agent for lung cancer.Jan 22, 2017

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Pubmed Data : Aging Dis. 2018 Aug ;9(4):590-604. Epub 2018 Aug 1. PMID: 30090649

Article Published Date : Jul 31, 2018

Study Type : Animal Study

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Substances : Fucoidan

Diseases : Parkinson's Disease

Pharmacological Actions : Neuroprotective Agents, Nrf2 activation

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Fucoidan enhances the effect of chemotherapeutic drug against drug-resistant lung cancer cells.Dec 31, 2022

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Pubmed Data : Pak J Pharm Sci. 2023 Jan ;36(1):89-97. PMID: 36967501

Pharmacological Actions : Anti-Adipogenic, Lipolytic

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"Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo."Sep 30, 2011

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Pubmed Data : Int J Biol Macromol. 2011 Oct 1 ;49(3):331-6. Epub 2011 May 23. PMID: 21624396

Article Published Date : Sep 30, 2011

Study Type : In Vitro Study

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Substances : Fucoidan

Diseases : Low Immune Function: Natural Killer Cells, Lung Cancer, Melanoma, Skin Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Immunostimulatory

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"Fucoidan from Seaweed Fucus vesiculosus Inhibits Migration and Invasion of Human Lung Cancer Cell via PI3K-Akt-mTOR Pathways."Dec 31, 2011

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Pubmed Data : Hear Res. 2011 Dec ;282(1-2):236-42. Epub 2011 Jul 23. PMID: 21810458

Article Published Date : Nov 30, 2011

Study Type : In Vitro Study

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Substances : Fucoidan

Diseases : Hair Loss: Drug-Induced, Neomycin Toxicity

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Hair Regeneration

Problem Substances : Neomycin

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"Fucoidan suppresses endocytosis in cultured HeLa cells."Aug 17, 2011

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Pubmed Data : Chin J Integr Med. 2011 Aug 18. Epub 2011 Aug 18. PMID: 21853347

Article Published Date : Aug 17, 2011

Study Type : In Vitro Study

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Substances : Fucoidan

Diseases : Cervical Cancer

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Additional Keywords : Natural Substance/Drug Synergy

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A review of the anticancer effects of fucoidan.Dec 31, 2013

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Pubmed Data : Adv Food Nutr Res. 2014 ;72:195-213. PMID: 25081084

Article Published Date : Dec 31, 2013

Study Type : Review

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Substances : Fucoidan

Diseases : Cancers: All

Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Antineoplastic Agents, Antioxidants

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A Review of the Immunomodulatory and anti-Inflammatory effects of fucoidan.Oct 12, 2020

Pubmed Data : Mar Drugs. 2018 Feb 2 ;16(2). Epub 2018 Feb 2. PMID: 29393871

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Pubmed Data : Mar Drugs. 2019 Sep 8 ;17(9). Epub 2019 Sep 8. PMID: 31500384

Article Published Date : Sep 07, 2019

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Pubmed Data : BMC Complement Altern Med. 2017 Aug 1 ;17(1):378. Epub 2017 Aug 1. PMID: 28764703

Article Published Date : Jul 31, 2017

Study Type : In Vitro Study

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Substances : Fucoidan

Diseases : Prostate Cancer

Pharmacological Actions : Anti-Angiogenic, Antineoplastic Agents, Antiproliferative

[+]

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Pubmed Data : Int J Biol Macromol. 2020 Feb 15. Epub 2020 Feb 15. PMID: 32070744

Article Published Date : Feb 14, 2020

Study Type : In Vitro Study

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Substances : Fucoidan, Seaweed

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Alpha-glucosidase inhibitor

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Fucoidan from Fucus vesiculosus attenuates doxorubicin-induced acute cardiotoxicity.Jul 21, 2020

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Pubmed Data : Biomed Pharmacother. 2020 Jul 22 ;130:110534. Epub 2020 Jul 22. PMID: 32711244

Article Published Date : Jul 21, 2020

Study Type : In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Anti-Apoptotic, Cardioprotective, Chemoprotective Agents

[+]

Fucoidan from Lessonia trabeculata induces apoptosis through caspase dependent and caspase-independent activation in 4T1 breast adenocarcinoma.May 28, 2024

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Pubmed Data : Mar Drugs. 2024 May 29 ;22(6). Epub 2024 May 29. PMID: 38921562

Article Published Date : May 28, 2024

Study Type : In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Antineoplastic Agents, Apoptotic

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View the Evidence: 451 Abstracts with Fucoidan Research

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Fucoidan as a promising drug for pain treatment: systematic review and meta-analysis.Jun 23, 2024

Antitumor activity of fucoidan: a systematic review and meta-analysis.Nov 30, 2021

"Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer."Feb 28, 2011

"Fucoidan suppresses IgE production in peripheral blood mononuclear cells from patients with atopic dermatitis."Jul 31, 2011

A fucoidan plant drink reduces Helicobacter pylori load in the stomach.Dec 31, 2022

Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection.May 13, 2012

Effects of fucoidan supplementation on inflammatory and immune response after high-intensity exercise.Nov 30, 2023

Effects of L-selectin stimulation (via fucoidan) of the expression of chemokine receptor CXCR4 on NK cells of healthy donors and tumor patients.Apr 30, 2012

Effects of oligo-fucoidan on the immune response, inflammatory status and pulmonary function in patients with asthma.Oct 27, 2022

Fermented Laminaria japonica supplementation may protect against progressive degeneration purportedly caused by reactive oxygen species.Dec 31, 2017

Fucoidan administration during a 3-month period in overweight or obese adults decreased diastolic blood pressure and LDL-C concentration.Jun 30, 2014

Fucoidan and fucoxanthin attenuate hepatic steatosis and inflammation of NAFLD.Mar 11, 2021

Fucoidan is a new potential therapeutic agent for the prevention and treatment of HTLV-1-associated diseases.Dec 31, 2010

Fucoidan supplementation restores fecal lysozyme concentrations in high-performance athletes.Aug 03, 2020

Low-molecular-weight fucoidan combined with chemotarget agents significantly improved the disease control rate.Apr 20, 2017

Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study.Feb 27, 2020

Oligo-fucoidan improved unbalance the Th1/Th2 and Treg/Th17 ratios in asthmatic patients.Dec 31, 2018

Oral administration of oligo fucoidan improves the survival rate, quality of life, and immunity in patients with lung cancer.Dec 31, 2023

Wheat peptides and fucoidan intervention could be utilized as a nutritional alternative to mitigate the progression of chronic gastritis.May 31, 2020

Fucoidan extract derived from Undaria pinnatifida exhibits anti-angiogenic properties.Jun 14, 2012

Fucoidan may be a potential treatment to diminish long-term sequelae from COVID-19.Jan 23, 2022

Protective effect of a fucose-rich fucoidan isolated from Saccharina japonica against ultraviolet B-induced photodamage.Jun 14, 2020

Anti-inflammatory effect of fucoidan isolated from fermented Sargassum fusiforme in in vitro and in vivo models.Oct 04, 2022

Anti-Inflammatory potential of fucoidan for atherosclerosis.May 16, 2022

Fucoidan alleviates renal fibrosis in diabetic kidney disease.Dec 31, 2021

Fucoidan enhances the chemotherapeutic sensitivity of capecitabine in colon cancer Sep 24, 2022

Fucoidan from Fucus vesiculosus inhibits inflammatory response.May 16, 2023

Fucoidan inhibits apoptosis and improves cardiac remodeling.Dec 31, 2022

Fucoidan/hyaluronic acid cross-linked zein nanoparticles loaded with fisetin as a novel targeted nanotherapy for oral cancer.Jun 29, 2023

Low molecular weight fucoidan inhibits pulmonary fibrosis.Dec 31, 2021

Protective effect of Sargassum fusiforme fucoidan against ethanol-induced oxidative damage.Apr 16, 2023

"Fucoidan extracted from Fucus evanescens brown algae corrects immunity and hemostasis disorders in experimental endotoxemia."Dec 31, 2008

"Fucoidan film safely inhibits surgical adhesions in a rat model."Nov 30, 2011

"Fucoidan protects against dopaminergic neuron death in vivo and in vitro."Aug 31, 2009

"Fucoidin, a neutrophil rolling inhibitor, reduces damage in a rat electrical burn injury model."Oct 31, 2011

"Hypolipidemic effect of fucoidan from Laminaria japonica in hyperlipidemic rats."Mar 31, 2010

"Low molecular weight fucoidan prevents intimal hyperplasia in rat injured thoracic aorta through the modulation of matrix metalloproteinase-2 expression."Jan 14, 2011

"Sulfated polysaccharide fucoidan ameliorates experimental autoimmune myocarditis in rats."Feb 28, 2011

"Suppression by fucoidan of liver fibrogenesis via the TGF-β/Smad pathway in protecting against oxidative stress."Dec 31, 2010

A combination of deep-sea water and fucoidan alleviates T2DM through modulation of gut microbiota and metabolic pathways.Mar 19, 2023

A fucoidan-supplemented diet can inhibit DMBA-induced tumors in rats.Oct 31, 2017

A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria.Feb 29, 2012

Administration of fucoidan to DU-145 prostate-bearing nude mice significantly reduced tumor volume and tumor weight.Jul 06, 2016

Algal fucoidan, unlike heparin, has thrombolytic activity in a murine arterial thrombosis model.Jun 30, 2012

An antithrombotic fucoidan, unlike heparin, does not prolong bleeding time in a murine arterial thrombosis model.Apr 30, 2012

Anthocyanin-fucoidan nanocomplex for preventing carcinogen induced cancer.Jul 02, 2020

Anti-hyperlipidemic effect of fucoidan fractions prepared from Iceland brown Algae Ascophyllum nodosum.Aug 25, 2023

Anti-metabolic syndrome effects of fucoidan from Fucus vesiculosus.Sep 11, 2019

Antibacterial efficacy of a fucoidan fraction extracted from Sargassum polycystum.Mar 14, 2019

Antinociceptive effects of fucoidan in rat models of vincristine-induced neuropathic pain.Jan 31, 2017

Antioxidative stress and anti-inflammatory activity of fucoidan nanoparticles against nephropathy of streptozotocin-induced diabetes.Dec 31, 2021

Antitumor activity of fucoidan against diffuse large B cell lymphoma in vitro and in vivo.Oct 31, 2015

Arabinogalactan and fucoidan have immunomodulatory effects that may contribute to the prevention of cancer. Dec 01, 2005

Curative effects of fucoidan on acetic acid induced ulcerative colitis,Jul 22, 2022

Dietary fucoidan from a brown marine algae attenuates lipid accumulation.Feb 10, 2022

Early use of fucoidan in diabetic individuals may minimize damage to testicular tissue.Mar 06, 2018

Ecklonia cava fucoidan has potential to stimulate natural killer cells in vivo.Aug 30, 2021

Effect of fucoidan on ethanol-induced liver injury and steatosis in mice and the underlying mechanism.Dec 31, 2020

Fucoidan administration enhanced morphologically healing of cartilage injury in rats.Dec 31, 2011

Fucoidan alleviated autoimmune diabetes.Dec 31, 2023

Fucoidan alleviated dextran sulfate sodium-induced ulcerative colitis.Nov 16, 2023

Fucoidan alleviates acetaminophen-induced hepatotoxicity.Dec 13, 2018

Fucoidan alleviates doxorubicin-induced cardiotoxicity.Jul 08, 2024

Fucoidan alleviates high sucrose-induced metabolic disorders and enhances intestinal homeostasis.May 30, 2024

Fucoidan ameliorated dextran sulfate sodium-induced ulcerative colitis.Nov 14, 2022

Fucoidan ameliorated the development of high fat diet-induced NAFLD.Oct 31, 2015

Fucoidan ameliorates acute and sub-chronic in vivo toxicity of the fungicide cholorothalonil.Mar 23, 2021

Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.Mar 14, 2022

Fucoidan ameliorates hepatic ischemia-reperfusion injury in mice.Sep 30, 2017

Fucoidan ameliorates hepatocellular carcinoma.Jul 27, 2020

Fucoidan ameliorates LPS-induced neuronal cell damage and cognitive impairment in mice.Sep 26, 2022

Fucoidan ameliorates oxidative stress, inflammation, DNA damage, and hepatorenal injuries in diabetic rats.Dec 31, 2019

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View the Evidence:
451 Abstracts with Fucoidan Research