Genistein

Name	AC	CK
Prostate Cancer	21	60
Postmenopausal Disorders	8	55
Osteoporosis	12	54
Breast Cancer	32	42
Insulin Resistance	8	41
Alzheimer's Disease	20	38
Osteopenia	6	36
Hot Flash	4	31
Obesity	12	27
Asthma	3	21
Postmenopausal Complications	1	20
Prostate Cancer: Prevention	2	20
Nonalcoholic fatty liver disease (NAFLD)	6	19
Ovarian Cancer	8	18
Oxidative Stress	13	18
Fatty Liver	5	17
Liver Cancer	15	17
Cancers: Drug Resistant	6	15
Aging	3	14
Diabetes Mellitus: Type 2	4	14
High Fat Diet	7	14
Hypothyroidism	3	14
Aging Skin	3	13
Cardiovascular Diseases	4	13
Pancreatic Cancer	11	13
Cancers: All	12	12
Colon Cancer	9	12
Endotoxemia	2	12
Fibroids: Uterine	3	12
Hepatic Steatosis	3	12
Brain Inflammation	6	11
Cholesterol: Oxidation	2	11
Chronic Obstructive Pulmonary Disease	2	11
Endometrial Cancer	2	11
Psoriasis	2	11
Atrophic Vaginitis (Vaginal Atrophy)	1	10
Breast Cancer: Triple Negative	5	10
Cervical Cancer	9	10
Chemotherapy Induced Myelotoxicity	1	10
Cognitive Decline/Dysfunction	5	10
Diabetic Complications	6	10
Hemodialysis	1	10
Hyperlipidemia	1	10
Liver: Fatty	1	10
Lower Urinary Tract Symptoms	1	10
Premenstrual syndrome	1	10
Prostate: PSA Doubling	1	10
Prostatic Hyperplasia: Benign	1	10
Inflammation	7	9
Hyperglycemia	4	8
Neurodegenerative Diseases	6	8
Bladder Cancer	6	7
Cystic Fibrosis	7	7
Hypertension	4	7
Ischemia	4	7
Lipopolysaccharide-Induced Toxicity	6	7
Cancer Metastasis	5	6
Endothelial Dysfunction	3	6
Lung Cancer	6	6
Radiation Induced Illness	3	6
Glioblastoma	4	5
Hyperpigmentation	1	5
Menopausal Syndrome	3	5
Osteoarthritis	4	5
Alcohol Toxicity	2	4
Autoimmune Diseases	2	4
Cerebral Ischemia	2	4
Chemically-Induced Liver Damage	2	4
Coronavirus Infection	3	4
Corticosteroid-Induced Toxicity	2	4
Diabetic Nephropathy	3	4
Liver Damage	2	4
Memory Impairment: Hormone Deficiency Induced	2	4
Polycystic Ovary Syndrome	2	4
Pulmonary Hypertension	2	4
Seizures	2	4
Wound Healing	3	4
Advanced Glycation End products (AGE)	2	3
Alcoholic Liver Disease	2	3
Arenaviral Hemorrhagic Fever	2	3
Bisphenol-A Toxicity	2	3
Breast Cancer: Chemically-Induced	2	3
Breast Cancer: Prevention	2	3
Chemotherapy-Induced Toxicity: Doxorubicin	2	3
DNA damage	3	3
Depression	2	3
Diabetes Mellitus: Type 1	2	3
Endometriosis	2	3
Estrogen Dominance	3	3
Glioma	3	3
Human Papillomavirus (HPV)	2	3
Hypoxia	2	3
Kidney Cancer	2	3
Kidney Diseases	2	3
Liver Cancer: Metastatic	2	3
Low Testosterone	2	3
Lymphoma	3	3
Melanoma	3	3
Metabolic Syndrome X	2	3
Mucopolysaccharidoses	2	3
Multiple Sclerosis	2	3
Neuroblastoma	3	3
Parkinson's Disease	2	3
Rheumatoid Arthritis	3	3
Squamous cell carcinoma	2	3
Ultraviolet Radiation Induced Damage	1	3
Acetaminophen (Tylenol) Toxicity	1	2
Amyotrophic Lateral Sclerosis	1	2
Amyotrophic lateral sclerosis (ALS)	1	2
Androgen Deficiency	1	2
B-cell prolymphocytic leukemia (B-PLL)	1	2
Bone Fractures	1	2
Brain Edema	1	2
Brain Ischemia	1	2
Burns	1	2
Cancer Stem Cells	2	2
Cancers: Multi-Drug Resistant	2	2
Chemotherapy-Induced Toxicity: Cisplatin	2	2
Clostridium Infections	1	2
Colitis	1	2
Colon Cancer: Prevention	1	2
Colorectal Cancer	2	2
Coronavirus Disease (Covid-19)	1	2
Cortisone Toxicity	1	2
Diabetes	1	2
Diabetes Mellitus: Type 1: Prevention	1	2
Diabetes: Cardiovascular Illness	1	2
Diabetes: Eye Disease	1	2
Diabetic Neuropathies	1	2
Diabetic Retinopathy	1	2
Drug-Induced Toxicity: Indomethacin	1	2
Encephalomyelitis	1	2
Esophageal Cancer	1	2
Gallbladder Cancer	2	2
Gastric Ulcer	1	2
Gastrointestinal Inflammation	1	2
HIV Infections	2	2
Heart Disease	1	2
Hemorrhagic Fevers: Viral	1	2
High Cholesterol	1	2
High Fructose Diet	1	2
High Sugar Diet	1	2
Hyperalgesia	1	2
Incontinence: Urinary	1	2
Infertility: Aging Associated	1	2
Infertility: Female	1	2
Infertility: Male	1	2
Inflammatory Bowel Diseases	1	2
Kidney Damage	1	2
Lead Poisoning	1	2
Learning disorders	1	2
Leiomyoma	2	2
Leukemia: B-Cell	1	2
Leukemia: Chronic Lymphocytic Leukemia (CLL)	1	2
Liver Cirrhosis	1	2
Liver Damage: Drug-Induced	1	2
Liver Disease	1	2
Liver Fibrosis	1	2
Low DHEA	1	2
Lupus Erythematosus: Systemic	1	2
Malaria	1	2
Mitochondrial Dysfunction	1	2
Muscle Atrophy	1	2
Myocardial Infarction	1	2
Nicotine/Tobacco Toxicity	1	2
Obsessive-Compulsive Disorder	1	2
Osteoarthritis: Knee	1	2
Osteomyelitis	1	2
Osteonecrosis	1	2
Osteoporosis: Male	1	2
Osteoporosis: Steroid-Induced	1	2
Osteosarcoma	2	2
Ovariectomy Associated Adverse Changes	1	2
Overactive Bladder	1	2
Pancreatitis	1	2
Phthalate Toxicity	1	2
Post-Traumatic Stress Disorders (PTSD)	1	2
Prediabetes	1	2
Prenatal Chemical Exposures	1	2
Prenatal Nutrition	1	2
Prenatal Nutrition: Health of the Offspring	1	2
Prostatitis: Acute	1	2
Prostatitis: Chronic	1	2
Radiation Induced Illness: Thoracic	1	2
Right Ventricular Hypertrophy	1	2
Sanfilippo Syndrome	1	2
Schistosomiasis	1	2
Sciatica	1	2
Septic Shock	1	2
Shock: Septic	1	2
Skin Cancer	2	2
Sleep Disorders	1	2
Spinal Cord Injuries	1	2
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	2
Steroid-Induced Toxicity	1	2
Stroke	1	2
Stroke: Attenuation/Recovery	1	2
Stroke: Ischemic	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Thyroid Cancer	2	2
Traumatic Brain Injury	1	2
Ulcerative Colitis	1	2
Abdominal Obesity (Midsection Fat)	1	1
Adenoviridae Infections	1	1
Aluminum Toxicity	1	1
Anxiety	1	1
Aortic Stenosis	1	1
Arteriosclerosis	1	1
Asthma: Bronchial	1	1
Atherosclerosis	1	1
BRCA1/BRCA2: Prevalence	1	1
Benzo[a]pyrene-induced Toxicity	1	1
Bone Cancer	1	1
Brain Cancer	1	1
Brain: Microglial Activation	1	1
Breast Cancer: BRCA1	1	1
Breast Cancer: Estrogen	1	1
Breast Cancer: estrogen receptor alpha-positive	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Cytomegalovirus Infections	1	1
Degenerative Disk Disease	1	1
Diabetes: Cataract	1	1
Dialysis: Renal	1	1
Dysbiosis	1	1
Ebola Virus Infections	1	1
Estrogen Deficiency	1	1
Fibroid Tumor	1	1
Fluoride Toxicity	1	1
Glioblastoma Multiforme	1	1
HSV-1	1	1
HSV-2	1	1
Head and Neck Cancer	1	1
Hemorrhagic Shock	1	1
Herpes Simplex Virus Type 2	1	1
High Cortisol	1	1
Intestinal Permeability	1	1
Iron Overload	1	1
Laryngeal Cancer	1	1
Leaky Gut Syndrome	1	1
Leukemia	1	1
Lymphoma: Burkitt	1	1
Mastocytoma	1	1
Memory Disorders	1	1
Multiple Myeloma	1	1
Myocardial Ischemia	1	1
Myocarditis	1	1
Nanoparticle Toxicity: Polystyrene	1	1
Nasopharyngeal Cancer	1	1
Ovarian Cancer: Estrogen Induced	1	1
Periodontal Diseases	1	1
Pesticide Toxicity	1	1
Pituitary Tumours	1	1
Radiotherapy	1	1
Retinoblastoma	1	1
Rotavirus Infections	1	1
Salivary Gland Adenoid Cystic Carcinoma.	1	1
Salivary Gland Diseases	1	1
Skin Diseases: Photo-Aging	1	1
Smoking	1	1
Staphylococcal Infections	1	1
Stomach Cancer	1	1
Testicular Cancer	1	1
Urinary Tract Cancer	1	1
Vascular Calcification	1	1

Name	AC	CK
Antioxidants	49	115
Anti-Inflammatory Agents	49	101
Apoptotic	69	94
Antiproliferative	62	77
Neuroprotective Agents	41	77
Tumor Necrosis Factor (TNF) Alpha Inhibitor	16	68
NF-kappaB Inhibitor	23	49
Chemopreventive	22	45
Hypoglycemic Agents	8	39
Antineoplastic Agents	14	36
Anti-Apoptotic	19	35
Cell cycle arrest	20	33
Interleukin-6 Downregulation	15	32
Anticarcinogenic Agents	14	26
Hepatoprotective	14	24
Chemosensitizer	15	22
Malondialdehyde Down-regulation	2	20
Osteoprotective	6	18
Gastrointestinal Agents	5	17
MicroRNA modulator	12	17
Chemotherapeutic	12	16
Enzyme Inhibitors	5	16
Anti-metastatic	13	15
Nrf2 activation	10	15
Cardioprotective	9	14
Insulin Sensitizers	3	14
Matrix metalloproteinase-2 (MMP-2) inhibitor	4	14
Anticholesteremic Agents	3	13
Estrogen Receptor Modulators	3	12
Immunomodulatory	8	12
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	12
Vasodilator Agents	2	12
Antiviral Agents	8	10
Interleukin-17 downregulation	1	10
Mitogen-activated protein kinase kinase 4 (MEK4)	1	10
Vascular Cell Adhesion Molecule-1 Inhibitor	1	10
Angiogenesis Inhibitors	7	9
Pancreato Protective Agents	5	9
Gastroprotective	4	8
Heme oxygenase-1 up-regulation	5	8
Hypolipidemic	5	8
Anti-Fibrotic	4	7
Interleukin-1 beta downregulation	4	7
Radiosensitizer	6	6
Renoprotective	4	6
Vascular Endothelial Growth Factor A Inhibitor	4	6
Radioprotective	3	5
Anti-Angiogenic	2	4
Cytoprotective	2	4
Histone deacetylase inhibitor	3	4
Interleukin-8 downregulation	3	4
Nitric Oxide Enhancer	2	4
Vascular Endothelial Growth Factor Inhibitors	3	4
Anti-Adipogenic	3	3
Anti-Anxiety Agents	2	3
Anti-Bacterial Agents	2	3
Anti-Glycation Agents	2	3
Bcl-2 protein down-regulation	2	3
Chemoprotective Agents	2	3
Cyclooxygenase 2 Inhibitors	3	3
Insulin-Like Growth Factor Inhibition/Downregulation	2	3
Secretagogue	2	3
Transforming growth factor beta (TGF-β) inhibitor	2	3
Tumor Suppressor Protein p53 Upregulation	3	3
Wnt/β-catenin signaling pathway modulation	2	3
Analgesics	1	2
Antidepressive Agents	1	2
Cell Differentiation Inducer	2	2
Cyclin D1 Down-Regulation	2	2
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Upregulation	1	2
Heme oxygenase-1 inducer	1	2
Hypotensive	1	2
Interleukin-10 downregulation	1	2
Interleukin-10 upregulation	1	2
Matrix Metalloproteinase-12 (MMP-12) Inhibitor	1	2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	2
Matrix metalloproteinase-8 (MMP-8) inhibitor	1	2
NF-E2-Related Factor-2 (Nrf2) Modulator	1	2
Neocardiogenic	1	2
P21 Activation	2	2
Prophylactic Agents	1	2
Protein Kinase Inhibitors	1	2
Regenerative	1	2
SIRT1 Activator	1	2
STAT3 Inhibitor	1	2
Spermatogenic	1	2
Steroidogenesis	1	2
Superoxide Dismutase Up-regulation	1	2
Antihypertensive Agents	1	1
Antimutagenic Agents	1	1
Aromatase Inhibitors	1	1
Bax/Bcl2 ratio: Increase	1	1
Bcl-xL down-regulation	1	1
Cytotoxicity	1	1
Drug synergy	1	1
Epidermal growth factor receptor (EGFR) inhibitor	1	1
Glucagon Like peptide 1 (GLP-1) Up-regulation	1	1
Glucose transporter-1 (GLUT1) expression down-regulation	1	1
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	1
Insulinotrophic	1	1
Interleukin-23 Downregulation	1	1
Phase II Detoxification Enzyme Inducer	1	1
Postaglandin PGE2 downregulation	1	1
Proteasome Inhibitors	1	1
Tyrosinase inhibitors	1	1
Vascular Endothelial Growth Factor Regulator	1	1
Wnt/β-catenin pathway down-regulation	1	1
anti-inflammatory	1	1
apoptosis	1	1

[+]

Dietary intake of isoflavone is inversely associated with the risk of lower urinary tract symptoms. Dec 01, 2007

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Pubmed Data : Br J Nutr. 2007 Dec;98(6):1237-42. Epub 2007 Jul 19. PMID: 17640419

Article Published Date : Dec 01, 2007

Study Type : Human Study

Additional Links

Substances : Genistein, Isoflavones, Soy

Diseases : Lower Urinary Tract Symptoms, Prostatic Hyperplasia: Benign

[+]

Effectiveness of genistein supplementation on metabolic factors and antioxidant Status in postmenopausal women with type 2 diabetes mellitus.Sep 30, 2019

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Pubmed Data : Can J Diabetes. 2019 Oct ;43(7):490-497. Epub 2019 May 4. PMID: 31307913

Article Published Date : Sep 30, 2019

Study Type : Human Study

Additional Links

Substances : Genistein

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Malondialdehyde Down-regulation

[+]

Effects of genistein aglycone in glucocorticoid induced osteoporosis.Jun 30, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2023 Jul ;163:114821. Epub 2023 May 9. PMID: 37167726

Pubmed Data : J Gastroenterol Hepatol. 2007 Nov;22(11):2009-14. PMID: 17914984

[+]

Higher concentrations of circulating genistein may reduce the risk of prostate cancer.Jun 02, 2009

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Pubmed Data : Br J Cancer. 2009 Jun 2;100(11):1817-23. Epub 2009 May 12. PMID: 19436304

Article Published Date : Jun 02, 2009

Study Type : Human Study

Additional Links

Substances : Genistein, phytoestrogens

Diseases : Prostate Cancer: Prevention

Pharmacological Actions : Chemopreventive

[+]

Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations.Jan 13, 2021

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Pubmed Data : Sci Rep. 2021 09 14 ;11(1):18297. Epub 2021 Sep 14. PMID: 34521933

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2016 Mar 28. Epub 2016 Mar 28. PMID: 27035424

Article Published Date : Mar 27, 2016

Study Type : Human Study

Additional Links

Substances : Genistein, Resveratrol

Diseases : Chronic Obstructive Pulmonary Disease

Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Soy extract appears to rejuvenate the structure of mature skin.Nov 01, 2004

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Pubmed Data : J Pediatr Gastroenterol Nutr. 2004 Nov;39(5):487-92. PMID: 15623355

Click here to read the entire abstract

Pubmed Data : J Med Food. 2006;9(3):368-72. PMID: 17004900

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Substances : Daidzein, Genistein, Isoflavones, Soy Protein

Diseases : Cholesterol: Oxidation, Hemodialysis

Pharmacological Actions : Antioxidants

[+]

The effect of genistein on lipid levels and LDLR, LXRα and ABCG1 expression in postmenopausal women with hyperlipidemia.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Diabetol Metab Syndr. 2019 ;11:111. Epub 2019 Dec 19. PMID: 31890045

Article Published Date : Dec 31, 2018

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Pubmed Data : J Invest Dermatol. 2003 May ;120(5):835-41. PMID: 12713590

Article Published Date : May 01, 2003

Study Type : Human Study

Additional Links

Substances : Genistein, NAC (N-acetyl-L-cysteine)

Diseases : Aging

Pharmacological Actions : Antioxidants

[+]

[+]

Biochanin A ameliorates histological changes of renal and cutaneous tissue related to ovariectomy and/or anastrozole treatment.May 15, 2018

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Pubmed Data : Life Sci. 2018 May 15 ;201:9-16. Epub 2018 Mar 19. PMID: 29567078

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Pubmed Data : Vascul Pharmacol. 2008 Jul;49(1):1-5. Epub 2008 Mar 27. PMID: 18468493

Article Published Date : Jul 01, 2008

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Diabetes: Cardiovascular Illness

Pharmacological Actions : Cardioprotective, Enzyme Inhibitors

[+]

Coffee contains the isoflavones genistein, daidzein and formononetin.Mar 10, 2010

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2010 Mar 10;58(5):3002-7. PMID: 20131840

Article Published Date : Mar 10, 2010

Study Type : Animal Study

Additional Links

Substances : Coffee, Daidzein, Genistein, Isoflavones

Additional Keywords : Substances that are Linked

[+]

Cytoprotective effect of genistein against dexamethasone-induced pancreatic β-cell apoptosis.Jul 27, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2022 Jul 28 ;12(1):12950. Epub 2022 Jul 28. PMID: 35902739

Article Published Date : Jul 27, 2022

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Inflammation

Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Cytoprotective, NF-kappaB Inhibitor, Pancreato Protective Agents

Problem Substances : Dexamethasone

[+]

Dietary genistein rescues reduced basal chloride secretion in diabetic jejunum.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Am J Epidemiol. 2008 Aug 27. [Epub ahead of print] PMID: 17554580

Article Published Date : Aug 27, 2008

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Osteoporosis: Male

[+]

Effects of genistein and exercise training on brain damage induced by a high-fat high-sucrose diet.Dec 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:1560435. Epub 2022 May 17. PMID: 35620577

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Reprod Biomed (Yazd). 2016 Feb ;14(2):95-102. PMID: 27200423

Article Published Date : Jan 31, 2016

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Infertility: Male

Pharmacological Actions : Spermatogenic

Problem Substances : Morphine

[+]

Genistein administration might improve liver damages induced by morphine in mice.Jul 04, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Chin Med J (Engl). 2018 Jul 5 ;131(13):1598-1604. PMID: 29941714

[+]

Genistein alleviates testicular ischemia and reperfusion injury-induced spermatogenic damage and oxidative stress.Jan 31, 2016

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Pubmed Data : J Physiol Pharmacol. 2016 Feb ;67(1):129-37. PMID: 27010902

Article Published Date : Jan 31, 2016

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Ischemia

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cytoprotective

[+]

Genistein ameliorated experimentally induced gastric ulcer.Nov 30, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Neurotox Res. 2020 Jul 1. Epub 2020 Jul 1. PMID: 32613603

Article Published Date : Jun 30, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Genistein

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Genistein and moderate intensity exercise were effective in reducing the severity of NASH.May 31, 2020

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Pubmed Data : BMC Complement Med Ther. 2020 Jun 1 ;20(1):162. Epub 2020 Jun 1. PMID: 32482167

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Med Ther. 2022 Aug 4 ;22(1):208. Epub 2022 Aug 4. PMID: 35927726

Article Published Date : Aug 03, 2022

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Inflammation, Oxidative Stress, Pancreatitis

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, NF-kappaB Inhibitor

[+]

Genistein attenuates acute cerebral ischemic damage. Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Eur J Pharmacol. 2010 Dec 15;649(1-3):242-8. Epub 2010 Sep 18. PMID: 20854807

Article Published Date : Dec 15, 2010

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Pulmonary Hypertension

Pharmacological Actions : Nitric Oxide Enhancer

[+]

Genistein attenuates renal ischemia-reperfusion injury.Dec 31, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Hum Exp Toxicol. 2023 ;42:9603271231164913. PMID: 36932924

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Ischemia, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Renoprotective

[+]

Genistein diet improves body weight, serum glucose and triglyceride levels.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Diabetes Metab Syndr Obes. 2019 ;12:2011-2021. Epub 2019 Oct 3. PMID: 31686880

Pubmed Data : Urology. 2004 Aug;64(2):389-93. PMID: 15302513

Article Published Date : Aug 01, 2004

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Kidney Cancer

[+]

Genistein Inhibits Clostridioides difficile Infection.Mar 27, 2023

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Pubmed Data : J Infect Dis. 2023 Mar 28 ;227(6):806-819. PMID: 36628948

Article Published Date : Mar 27, 2023

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Clostridium Infections

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents

[+]

Genistein inhibits high fat diet-induced obesity through miR-222 by targeting BTG2 and adipor1.Feb 29, 2020

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Pubmed Data : Food Funct. 2020 Mar 1 ;11(3):2418-2426. Epub 2020 Mar 4. PMID: 32129363

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Pubmed Data : Shock. 2019 Oct 15. Epub 2019 Oct 15. PMID: 31626039

Article Published Date : Oct 14, 2019

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Burns

Pharmacological Actions : Antioxidants, Cardioprotective

[+]

Genistein protects against hyperglycemia and fatty liver disease in diet-induced prediabetes.Dec 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Neurotoxicology. 2016 Mar ;53:153-164. Epub 2016 Jan 18. PMID: 26797587

Article Published Date : Feb 29, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Genistein

Diseases : Lead Poisoning, Neurodegenerative Diseases

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Superoxide Dismutase Up-regulation

Problem Substances : Lead

[+]

Genistein reduces hyperglycemia and pancreatic islet cell loss in a rat model of diabetic pancreatic damage.Feb 01, 2007

Genistein supplementation might be a potential therapeutic line for the management and prevention of diabetes-associated OCD.Mar 20, 2018

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Pubmed Data : J Basic Clin Physiol Pharmacol. 2018 Mar 21. Epub 2018 Mar 21. PMID: 29561730

Article Published Date : Mar 20, 2018

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Diabetic Complications, Obsessive-Compulsive Disorder

Pharmacological Actions : Neuroprotective Agents

[+]

Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer.Feb 07, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Low dose of genistein alleviates phthalate-induced fetal testis disorder.Dec 31, 2019

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Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:4569268. Epub 2020 May 27. PMID: 32566080

Article Published Date : Dec 31, 2019

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Pubmed Data : Nutrients. 2022 Apr 29 ;14(9). Epub 2022 Apr 29. PMID: 35565830

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Pubmed Data : J Environ Pathol Toxicol Oncol. 2019 ;38(2):143-152. PMID: 31679277

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Pubmed Data : PLoS One. 2014 ;9(5):e96155. Epub 2014 May 15. PMID: 24830850

Soy has an anti-inflammatory effect on experimentally-induced prostatitis in rats. May 01, 2007

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Pubmed Data : Exp Biol Med (Maywood). 2007 May;232(5):674-81. PMID: 17463164

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Pubmed Data : Lupus. 2008 Sep;17(9):814-21. PMID: 18755863

Article Published Date : Sep 01, 2008

Study Type : Animal Study

Additional Links

Substances : Genistein, Isoflavones

Diseases : Autoimmune Diseases, Lupus Erythematosus: Systemic

[+]

Soy phytochemicals prevent growth and metastasis of bladder cancer in mice. Feb 01, 2006

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Pubmed Data : Cancer Res. 2006 Feb 1;66(3):1851-8. PMID: 16452247

Article Published Date : Feb 01, 2006

Study Type : Animal Study

Additional Links

Substances : Daidzein, Genistein, Isoflavones

Diseases : Bladder Cancer

Pharmacological Actions : Apoptotic, Cell cycle arrest, Insulin-Like Growth Factor Inhibition/Downregulation, NF-kappaB Inhibitor

[+]

Soy phytochemicals synergistically enhance the preventive effect of tamoxifen on the growth of estrogen-dependent human breast carcinoma in mice.Jun 01, 2007

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Pubmed Data : Carcinogenesis. 2007 Jun;28(6):1217-23. Epub 2007 Jan 18. PMID: 17234721

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Pubmed Data : Biochem Cell Biol. 2010 Aug;88(4):737-45. PMID: 20651847

Article Published Date : Aug 01, 2010

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Genistein, Polyphenols, Resveratrol

Diseases : Aging, Infertility: Aging Associated, Infertility: Female

Additional Keywords : Plant Extracts, Stilbenes

[+]

The regulatory effect of genistein on granulosa cell in ovary of rat with polycystic ovarian syndrome.Aug 29, 2018

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Pubmed Data : J Tradit Complement Med. 2021 Nov ;11(6):503-512. Epub 2021 May 3. PMID: 34765514

Article Published Date : Oct 31, 2021

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : High Fat Diet, High Fructose Diet, Nonalcoholic fatty liver disease (NAFLD)

Therapeutic Actions : Exercise

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, Matrix Metalloproteinase-12 (MMP-12) Inhibitor

[+]

This study concluded that genistein prevented endometriosis by performing the antiangiogenic activity and showed a similar function to estradiol.Dec 31, 2023

Antiobesity effects of phytochemicals from an epigenetic perspective.Dec 20, 2020

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Pubmed Data : Nutrition. 2020 Dec 21 ;84:111119. Epub 2020 Dec 21. PMID: 33476999

Article Published Date : Dec 20, 2020

Study Type : Review

Additional Links

Substances : Curcumin, Genistein, Isothiocyanates

Diseases : Obesity

Pharmacological Actions : Antioxidants

Additional Keywords : Anti-Obesity Agents, Epigenetic Modification

[+]

Beneficial role of the phytoestrogen genistein on vascular calcification.Aug 23, 2017

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Pubmed Data : J Nutr Biochem. 2017 Aug 24 ;50:26-37. Epub 2017 Aug 24. PMID: 28968518

Article Published Date : Aug 23, 2017

Study Type : In Vitro Study

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Substances : Genistein

Diseases : Vascular Calcification

[+]

BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.Feb 12, 2006

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Pubmed Data : Biochem Biophys Res Commun. 1997 Apr 28;233(3):692-6. PMID: 9168916

Article Published Date : Apr 28, 1997

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Genistein, Isoflavones

Diseases : Breast Cancer, Pesticide Toxicity

Pharmacological Actions : Antiproliferative

Additional Keywords : Drug-Plant-Vitamin Synergies

[+]

Dietary factors modify miRNA expression and their mRNA targets in various cancer processes.Oct 31, 2011

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Pubmed Data : Adv Nutr. 2011 Nov ;2(6):472-85. Epub 2011 Nov 3. PMID: 22332090

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Pubmed Data : J Food Sci. 2019 Aug ;84(8):2330-2336. Epub 2019 Jul 17. PMID: 31313321

Article Published Date : Jul 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Atherosclerosis

Pharmacological Actions : Anticholesteremic Agents

[+]

Effects of genistein on anti-tumor activity of cisplatin in human cervical cancer cell lines.Aug 31, 2019

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Pubmed Data : Obstet Gynecol Sci. 2019 Sep ;62(5):322-328. Epub 2019 Aug 6. PMID: 31538075

Article Published Date : Aug 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Cervical Cancer

Pharmacological Actions : Chemotherapeutic, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

Effects of genistein on common kidney diseases. Sep 12, 2022

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Pubmed Data : Phytother Res. 2021 Mar 30. Epub 2021 Mar 30. PMID: 33786876

Article Published Date : Mar 29, 2021

Study Type : Review

Additional Links

Substances : Biochanin A, Diosmin , EGCG (Epigallocatechin gallate), Epicatechin, Flavonoids, Genistein, Hesperidin, Luteolin, Naringenin , Quercetin, Rutin, Silymarin

Diseases : Coronavirus Infection

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Cytokine Storm

[+]

Flavonoids on diabetic nephropathy: advances and therapeutic opportunities. Aug 06, 2021

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Pubmed Data : Int J Mol Sci. 2023 Feb 12 ;24(4). Epub 2023 Feb 12. PMID: 36835090

Article Published Date : Feb 11, 2023

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids, Genistein, Procyanidin B2

Diseases : DNA damage, Oxidative Stress

Pharmacological Actions : Antioxidants, Nrf2 activation

Additional Keywords : Proanthocyanidins

[+]

Genistein and resveratrol can reverse the cell death and oxidant production associated with benzo(e)pyrene exposure.Sep 14, 2010

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Pubmed Data : World J Gastroenterol. 2010 Sep 14;16(34):4313-20. PMID: 19959636

Article Published Date : Sep 14, 2010

Study Type : In Vitro Study

Additional Links

Substances : Genistein, Resveratrol, Stilbenes

Diseases : Benzo[a]pyrene-induced Toxicity , Smoking

Pharmacological Actions : Anti-Apoptotic, Antioxidants

[+]

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Pubmed Data : Int J Prev Med. 2015 ;6:54. Epub 2015 Jun 17. PMID: 26180625

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Dose Response

[+]

Genistein combined polysaccharide can inhibit intracrine androgen synthesis in prostate cancer cells.Aug 10, 2020

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Pubmed Data : Biomedicines. 2020 Aug 11 ;8(8). Epub 2020 Aug 11. PMID: 32796613

Article Published Date : Aug 10, 2020

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Prostate Cancer

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Polysaccharides

[+]

Genistein combined with doxorubicin had a synergistic effect on MCF-7/Adr cells.Sep 30, 2014

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Pubmed Data : Oncol Rep. 2014 Oct ;32(4):1647-53. Epub 2014 Jul 29. PMID: 25109508

Article Published Date : Sep 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Breast Cancer, Cancers: Drug Resistant

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Cell cycle arrest

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

[+]

Genistein counteracts the antilipolytic action of insulin in rat fat cells. Mar 01, 2008

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Pubmed Data : J Steroid Biochem Mol Biol. 2008 Mar;109(1-2):108-14. Epub 2007 Dec 7. PMID: 18207734

Article Published Date : Mar 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Genistein

[+]

Genistein derivatives inhibit estrogen receptor alpha-positive breast cancer.May 15, 2011

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Pubmed Data : Cancer Biol Ther. 2011 May 15 ;11(10):883-92. Epub 2011 May 15. PMID: 21389782

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[+]

Genistein inhibits A549 human lung cancer cell proliferation.Aug 31, 2016

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Pubmed Data : Oncol Lett. 2016 Sep ;12(3):2189-2193. Epub 2016 Jul 6. PMID: 27602162

Article Published Date : Aug 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, MicroRNA modulator

Additional Keywords : Dose Response

[+]

Genistein inhibits angiogenesis developed during rheumatoid arthritis.Apr 30, 2020

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Pubmed Data : J Orthop Translat. 2020 May ;22:92-100. Epub 2019 Aug 23. PMID: 32440504

Article Published Date : Apr 30, 2020

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Interleukin-6 Downregulation, Vascular Endothelial Growth Factor Inhibitors

[+]

Genistein inhibits cell proliferation and increases programmed cell death in human colon cancer cells. Jan 01, 2005

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Pubmed Data : J Med Food. 2005;8(4):431-8. PMID: 16379552

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Pubmed Data : Mol Med Rep. 2018 May ;17(5):7265-7273. Epub 2018 Mar 16. PMID: 29568950

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Pubmed Data : Int J Cancer. 2006 Apr 15;118(8):1930-6. PMID: 16284950

Article Published Date : Apr 15, 2006

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Pancreatic Cancer

Pharmacological Actions : NF-kappaB Inhibitor

[+]

Genistein inhibits proliferation and metastasis in human cervical cancer cells.Feb 16, 2023

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Pubmed Data : Molecules. 2023 Feb 17 ;28(4). Epub 2023 Feb 17. PMID: 36838908

Article Published Date : Feb 16, 2023

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Cervical Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative

[+]

Genistein inhibits the growth and regulates the migration and invasion abilities of melanoma.Mar 27, 2017

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Pubmed Data : Oncotarget. 2017 Mar 28 ;8(13):21674-21691. PMID: 28423510

Article Published Date : Mar 27, 2017

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Melanoma

Pharmacological Actions : Anti-metastatic

Additional Keywords : Anti-metastatic, Genistein, melanoma

[+]

Click here to read the entire abstract

Pubmed Data : Menopause. 2006 Sep-Oct;13(5):831-9. PMID: 16932241

Article Published Date : Sep 01, 2006

Study Type : Review

Additional Links

Substances : Genistein

Diseases : Hot Flash

[+]

Genistein may be a dietary phytochemical with potential to target prostate cancer stem cells (CSCs). Apr 03, 2012

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Pubmed Data : Cancer Lett. 2012 Apr 3. Epub 2012 Apr 3. PMID: 22484470

Article Published Date : Apr 03, 2012

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Cancer Stem Cells, Prostate Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Cancer Stem Cells

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View the Evidence: 431 Abstracts with Genistein Research

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Genistein significantly improves glucose control and insulin sensitivity in postmenopausal women.Feb 28, 2017

Dietary intake of isoflavone is inversely associated with the risk of lower urinary tract symptoms. Dec 01, 2007

Effectiveness of genistein supplementation on metabolic factors and antioxidant Status in postmenopausal women with type 2 diabetes mellitus.Sep 30, 2019

Effects of genistein aglycone in glucocorticoid induced osteoporosis.Jun 30, 2023

Fermented soy therapy may have therapeutic value in treating platinum-resistant ovarian cancer. Jan 01, 2006

Genistein and daidzein consumption are associated with a lower risk of prostate cancer. Aug 01, 2009

Genistein and puerarin could inhibit the pathway of NF-kappaB and TNF-alpha in asthma patients.Jan 31, 2010

Genistein appears to have a positive effect on hot flushes without a negative impact on endometrial thickness in early postmenopausal women.Jul 01, 2004

Genistein can reduce insulin resistance, oxidative and inflammatory indices along with improvement in fat metabolism in patients with NAFLD.May 31, 2017

Genistein compares favorably to HRT in supporting bone health in early postmenopausal women.Oct 01, 2002

Genistein has a positive effect on bone metabolism in osteopenic postmenopausal women, without increasing endometrial thickness. Jun 19, 2007

Genistein has favorable effects on some predictors of cardiovascular risk in osteopenic, postmenopausal women.Jan 18, 2010

Genistein has therapeutic value in reducing PSA levels in men with prostate cancer. Feb 01, 2004

Genistein induces long-term expression of progesterone receptor regardless of estrogen receptor status and improves the prognosis of endometrial cancer patients.Jun 17, 2022

Genistein inhibits nonalcoholic fatty liver disease.Nov 01, 2007

Genistein is safe and effective in improving bone density without adverse responses in breast density or endometrium thickness in osteopenic, postmenopausal women. Dec 01, 2008

Genistein may block metastasis and mortality in prostate cancer through blocking the activation of MEK4 and MMP-2 expression. Aug 19, 2009

Genistein reduces vasomotor symptoms, e.g. hot flush, within postmenopausal women.Jul 01, 2007

Genistein significantly decreases hot flash symptoms in healthy postmenopausal women.Feb 01, 2011

Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects. Dec 31, 2019

Higher concentrations of circulating genistein may reduce the risk of prostate cancer.Jun 02, 2009

Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations.Jan 13, 2021

Increased consumption of genistein is associated with better lung function in patients with asthma. Jan 01, 2004

Lycopene and soy isoflavones have activity in prostate cancer patients with PSA relapse disease and may delay progression of both hormone-refractory and hormone-sensitive prostate cancer.Jul 01, 2009

Resveratrol and genistein may be potential drugs candidates for use in the treatment of COPD.Mar 27, 2016

Soy extract appears to rejuvenate the structure of mature skin.Nov 01, 2004

Soy isoflavone consumption reduce symptoms of premenstrual syndrome. May 01, 2005

Soy isoflavones ameliorate the adverse effects of chemotherapy in children.Oct 01, 1996

Soy isoflavones may benefit some patients with prostate cancer. Jan 01, 2003

Soy protein reduces cholesterol oxidation in patients on hemodialysis. Jan 01, 2006

The effect of genistein on lipid levels and LDLR, LXRα and ABCG1 expression in postmenopausal women with hyperlipidemia.Dec 31, 2018

The soy isoflavone genistein does not adversely effect thyroid function in osteopenic, postmenopausal women. Mar 31, 2010

There is a modest inverse association between lignan excretion and uterine fibroid risk. Jan 01, 2005

This study shows that genistein may have a role in therapeutics to delay the onset of Alzheimer's dementia.Nov 03, 2022

Topical N-acetyl cysteine and genistein prevent ultraviolet-light-induced signaling that leads to photoaging in human skin in vivo.May 01, 2003

Vaginally administered genistein and hyaluronic acid both improve symptoms of vaginal atrophy in postmenopausal women.May 31, 2011

Biochanin A from red clover inhibits melanogenesis and may be helpful for hyperpigmentation disorders.Jan 01, 2011

The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.Oct 31, 2016

Genistein attenuates memory impairment in Alzheimer's disease.Aug 02, 2022

Genistein protects against ultraviolet B-induced wrinkling and photoinflammation in in vitro and in vivo models.Feb 23, 2022

Dietary genistein supplementation protects against lipopolysaccharide-induced intestinal injury through altering transcriptomic profile.Jun 30, 2020

Genistein attenuates cognitive deficits and neuroapoptosis in hippocampus induced by ketamine exposure.Jul 07, 2020

"Genistein reduced insulin resistance index through modulating lipid metabolism in ovariectomized rats."Oct 31, 2012

"Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome."Mar 31, 2006

A soy extract may be more effective than purified genistein in improving tibial trabecular bone quality in ovariectomized mice. Jul 01, 2009

Administration of genistein was found to have an effect on the amount of trace elements in the bone tissue of rats with breast cancer.Mar 20, 2024

Administration of N- acetylcysteine and genistein have an additive gastroprotective effect in indomethacin induced gastric injury.Jul 15, 2018

Antibacterial and anti-inflammatory effects of genistein in Staphylococcus aureus induced osteomyelitis.Mar 31, 2023

As mono-therapy the natural isoflavone genistein has a powerful therapeutic effect in vivo on A431 and Colo205 tumors.Apr 06, 2016

Biochanin A ameliorates histological changes of renal and cutaneous tissue related to ovariectomy and/or anastrozole treatment.May 15, 2018

Bone strength is improved with genistein treatment in mice with diet-induced obesity.Oct 31, 2019

Chemopreventive and hepatoprotective effects of genistein.Nov 30, 2022

Chronic treatment of diabetic rats with genistein could prevent the abnormal functional changes in vascular reactivity in diabetic rats. Jul 01, 2008

Coffee contains the isoflavones genistein, daidzein and formononetin.Mar 10, 2010

Cytoprotective effect of genistein against dexamethasone-induced pancreatic β-cell apoptosis.Jul 27, 2022

Dietary genistein rescues reduced basal chloride secretion in diabetic jejunum.Dec 31, 2015

Dietary soy isoflavones and estrone protect ovariectomized mice from carcinogen-induced colon cancer.Jan 01, 2004

Dietary soy protein isolate attenuates metabolic syndrome in rats. Aug 01, 2009

Dried plum supplementation reverses bone loss in osteopenic castrated rats.Aug 27, 2008

Effects of genistein and exercise training on brain damage induced by a high-fat high-sucrose diet.Dec 31, 2021

Enterolactone and enterodiol have been shown to negate the tumor-stimulating effect of genistein in a mouse model of breast cancer.Jul 01, 2007

Equol and genistein compare favorably with hormone replacement therapy (estradiol) on bone quality in a rat osteopenia model. Dec 09, 2009

Genistein owers blood pressure in spontaneously hypertensive rats.Feb 01, 2008

Genistein administration could increase the quality of spermatozoa and prevent morphine- induced adverse effects on sperm parameters.Jan 31, 2016

Genistein administration might improve liver damages induced by morphine in mice.Jul 04, 2018

Genistein administration reduces cytokine induction in whole-body gamma irradiated mice.Nov 01, 2009

Genistein aglycone might be an effective alternative therapy for the management of age-related skin changes in postmenopausal women.Jan 31, 2012

Genistein alleviated DSS-caused colonic injury, inflammation, and gut dysfunction.Sep 21, 2017

Genistein alleviates dextran sulfate sodium-induced colitis.Apr 08, 2024

Genistein alleviates high-fat diet-induced obesity.Apr 07, 2022

Genistein alleviates testicular ischemia and reperfusion injury-induced spermatogenic damage and oxidative stress.Jan 31, 2016

Genistein

View the Evidence:
431 Abstracts with Genistein Research