Ginkgo biloba

Name	AC	CK
Alzheimer's Disease	55	162
Dementia	17	161
Cognitive Decline/Dysfunction	17	121
Stroke: Ischemic	20	104
Tinnitus	12	97
Cerebral Ischemia	29	64
Inflammation	38	59
Depression	10	56
Oxidative Stress	38	56
Tardive Dyskinesia	5	52
Parkinson's Disease	19	49
Angina Pectoris	2	41
Lipopolysaccharide-Induced Toxicity	23	39
Glaucoma	9	37
Memory Disorders	9	34
Cardiovascular Diseases	8	32
Aging Skin	3	30
Smell Disorders	3	30
Atherosclerosis	13	29
Brain Ischemia	16	29
Diabetes Mellitus: Type 2	7	28
Anxiety	5	26
Arsenic Poisoning	2	25
Aging: Brain	9	23
Intracerebral Hemorrhage	2	23
Liver Cancer	10	22
Ischemia: Myocardial	1	21
Migraine Disorders	3	21
Stroke	6	21
Vitiligo	3	21
Anxiety Disorders	1	20
Arteriosclerosis	2	20
Generalized Anxiety Disorder	1	20
Intermittent Claudication	2	20
Migraines	2	20
Brain Inflammation	10	19
Neurodegenerative Diseases	13	16
Pulmonary Fibrosis	4	16
Osteoarthritis	7	15
Asthma	5	14
Endothelial Dysfunction	9	14
Macular Degeneration	5	14
Hearing Loss	3	13
Myocardial Ischemia	7	13
Stroke: Attenuation/Recovery	3	13
Brain Damage	2	12
Colitis	6	12
Hypertension	2	12
Raynaud Disease	2	12
Schizophrenia	3	12
Traumatic Brain Injury	2	12
Attention Deficit Disorder	2	11
Attention Deficit Disorder with Hyperactivity	2	11
Breast Cancer	8	11
Chemically-Induced Liver Damage	7	11
Chemotherapy-Induced Toxicity: Bleomycin	5	11
Vertigo	2	11
Aging	7	10
Aluminum Toxicity	5	10
Anosmia	1	10
Arterial Thickening	1	10
Asthma: Bronchial	1	10
Athletic Performance	1	10
Autism	1	10
Autism Spectrum Disorders	1	10
Chemotherapy-Induced Toxicity: Cisplatin	5	10
Conjunctivitis	1	10
Corticosteroid-Induced Toxicity	1	10
Diabetic Microangiopathy	1	10
Diabetic Nephropathy	6	10
Dizziness	1	10
Dystrophic retinal detachment (DRD)	1	10
Eye Diseases: Vitreous Disorders	1	10
Gastric Cancer	6	10
Graves Disease: Radioiodine therapy	1	10
Head Injuries	1	10
Headache	1	10
Interstitial Lung Diseases	1	10
Multiple Sclerosis	6	10
Nonalcoholic fatty liver disease (NAFLD)	6	10
Olfaction Disorders	1	10
Peripheral Arterial Disease	1	10
Peripheral Vascular Diseases	1	10
Peripheral vitreochoreoretinal dystrophies (PVCRD)	1	10
Premenstrual syndrome	1	10
Radiation-Induced Illness: Radioiodine (Iodine-131)	1	10
Retinal Detachment	1	10
Schizophrenic Disorders	1	10
Vertebrobasilar Insufficiency	1	10
Wrinkles	1	10
Liver Damage: Drug-Induced	5	9
Cholesterol: Oxidation	6	8
Diabetic Complications	5	8
Liver Fibrosis	4	8
Lung Cancer	6	8
Obesity	5	8
Osteoporosis	4	8
Cancers: All	7	7
Cardiomyopathy	4	7
Pulmonary Fibrosis: Bleomycin-Induced	3	7
DNA damage	2	6
Drug-Induced Toxicity: Methotrexate	3	6
Hearing Loss: Noise-Induced	3	6
Hypoxia	5	6
Lung Damage	2	6
Mitochondrial Dysfunction	5	6
Myocardial Infarction	4	6
Neuropathic Pain	4	6
Polycystic Kidney Diseases	2	6
Staphylococcus aureus infection	5	6
Subarachnoid hemorrhage	3	6
Brain: Oxidative Stress	3	5
Carcinoma: Non-Small-Cell Lung	5	5
Cervical Cancer	3	5
Colon Cancer	4	5
Coronavirus Disease (Covid-19)	5	5
Coronavirus Infection	5	5
Hydrogen Peroxide Induced Toxicity	4	5
Kidney Damage	3	5
Brain: Microglial Activation	3	4
Cancer Metastasis	4	4
Diabetic Retinopathy	3	4
Fluoride Toxicity	2	4
Gastric Ulcer	2	4
Herpes Simplex Virus Type 1	3	4
Hypertension: Pulmonary	2	4
Ischemia	2	4
Kidney Damage: Chemically-Induced	2	4
Kidney Damage: Drug-Induced	2	4
Learning disorders	2	4
Liver Cirrhosis	2	4
Melanoma	3	4
Memory Loss	2	4
Oral Cancer	4	4
Ovarian Cancer	4	4
Pancreatic Cancer	3	4
Rheumatoid Arthritis	3	4
Sepsis	2	4
Spinal Cord Injuries	2	4
Squamous cell carcinoma	4	4
Streptococcus Infections	2	4
Testicular Injury: Chemical/Metal Induced	2	4
Amyotrophic Lateral Sclerosis	2	3
Cancers: Multi-Drug Resistant	2	3
Chemotherapy-Induced Toxicity: Doxorubicin	2	3
Chemotherapy-Induced Toxicity: Peripheral Neuropathy	1	3
Colorectal Cancer	3	3
Cysts	1	3
Endometrial Cancer	1	3
Fatty Liver	2	3
Heart Disease	1	3
Heart Failure	2	3
Insulin Resistance	2	3
Lipid Peroxidation	3	3
Metabolic Diseases	2	3
Nasopharyngeal Cancer	2	3
Neurological Conditions	3	3
Parkinsonian Disorders	1	3
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	3
Surgery: Anesthesiology	2	3
Ulcerative Colitis	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Acrylamide-induced toxicity	1	2
Acute lymphoblastic leukemia (ALL)	1	2
Advanced Glycation End products (AGE)	1	2
Aging: Heart	1	2
Aging: Liver	1	2
Alcohol Toxicity	2	2
Allergic Airway Diseases	1	2
Altitude Sickness	1	2
Amnesia	1	2
Aneurysm: Aortic	1	2
Aspirin-Induced Toxicity	1	2
Atopic Dermatitis	1	2
Bisphenol Toxicity	1	2
Brain Injury: Traumatic	1	2
Burns	1	2
Burns: Severe	1	2
Cancers: Drug Resistant	2	2
Cardiac Hypertrophy	1	2
Cartilage Injury	1	2
Cataract	1	2
Cataract: Radiation-Induced	1	2
Cerebral Hypoperfusion	1	2
Cerebral Stroke	1	2
Cerebral Vasospasm	1	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Kidney Damage	1	2
Chronic Obstructive Lung Disease	1	2
Chronic Obstructive Pulmonary Disease	1	2
Cirrhosis	1	2
Clotting	1	2
Cochlear Neuronal Damage	1	2
Covid: Long	2	2
Degenerative Disk Disease	2	2
Diabetes Mellitus: Type 1	1	2
Diabetes: Cataract	1	2
Diabetic Neuropathy	1	2
Diesel Exhaust Particle Toxicity	1	2
Dopamine Deficiency	1	2
Drug Toxicity: Methotrexate	1	2
Dyslipidemias	1	2
Dysmensia	1	2
Ebola	2	2
Edema	1	2
Electromagnetic Radiation Mitigation	1	2
Escherichia coli Infections	2	2
Fibrosis	1	2
Glioblastoma	2	2
Glomerulosclerosis	1	2
Glyphosate Toxicity	1	2
Guillain-Barre Syndrome	1	2
HIV Infections	2	2
Hair Loss	1	2
Hemorrhagic Shock	1	2
High Fat Diet	1	2
Homocysteine: Elevated	1	2
Immune Dysregulation: TH1/TH2 imbalance	1	2
Infertility: Male	1	2
Inflammatory Bowel Diseases	1	2
Influenza	1	2
Influenza A	2	2
Iron Overload	1	2
Kidney Cancer	2	2
Kidney Diseases	1	2
Klebsiella Infections	2	2
Lead Poisoning	1	2
Liver Cancer: Hepatitis B Associated	1	2
Liver Cancer: Prevention	1	2
Liver Damage	2	2
Liver Injury: Ischemia/reperfusion	1	2
Low Libido	1	2
Lymphoma	1	2
Mercury Poisoning	1	2
Microplastic Toxicity	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Mobile Phone-Induced Oxidative Stress	1	2
Morphine Tolerance/Dependence	1	2
Multiple Myeloma	2	2
Muscle Atrophy	1	2
Myocardial Fibrosis	1	2
Myopia	1	2
Myringosclerosis	1	2
Neuroblastoma	1	2
Neurological Disorders	1	2
Ocular Hypertension: Steroid-Induced	1	2
Orofacial Dyskinesia	1	2
Otosclerosis	1	2
Pancreatic Cancer: Metastatic	1	2
Pancreatitis	1	2
Peripheral Nerve Diseases	1	2
Peripheral Neuropathies	1	2
Pesticide Toxicity	2	2
Petroleum Exposure And Toxicity	1	2
Pets: Behavior Disturbances in Elderly Animals	1	2
Pneumonia	1	2
Postoperative Recovery	1	2
Prion Diseases	2	2
Prostate Cancer	2	2
Psychiatric Disorder: Conditioned Fear	1	2
Psychiatric Disorders	2	2
Renal Fibrosis	1	2
Retinopathy of Prematurity	1	2
Right Ventricular Hypertrophy	1	2
Sarcopenia	1	2
Sperm Quality: Low	1	2
Statin-Induced Pathologies	1	2
Steroid-Induced Toxicity	1	2
Stroke: Hemorrhagic	1	2
Thrombosis	1	2
Uranium Poisoning	1	2
Wound Healing	1	2
Acinetobacter baumannii infection	1	1
Bladder Cancer	1	1
Candida Albicans	1	1
Cardiomegaly	1	1
Central Nervous System Diseases	1	1
Chemotherapy-Induced Toxicity: Gentamicin	1	1
Chikungunya Virus	1	1
Cyanide Poisoning	1	1
Endothelial Damage	1	1
Enterococcus Infections	1	1
Epstein-Barr Virus Infections	1	1
Excitotoxicity	1	1
Eye Damage	1	1
Gram-Negative Bacterial Infections	1	1
H3N2 Infection	1	1
Hepatitis B	1	1
Herpes Simplex Virus Type 2	1	1
Hypoxia: Brain	1	1
Low Testosterone	1	1
Malaria	1	1
Mastalgia	1	1
Measles	1	1
Medulloblastoma	1	1
Metabolic Syndrome X	1	1
Neurologic Disorders	1	1
Optic Neuritis	1	1
Osteosarcoma	1	1
Pseudomonas aeruginosa	1	1
Retinal Diseases	1	1
Smoking Cessation: Nicotine Addiction	1	1
Streptococcus pyogenes	1	1
Tin Poisoning	1	1
Toxoplasma gondii Infection	1	1
Upper Respiratory Infections	1	1
Vasculitis	1	1
Vesicular Stomatitis Virus	1	1
Zika Virus	1	1

Name	AC	CK
Neuroprotective Agents	196	589
Anti-Inflammatory Agents	138	289
Antioxidants	105	245
Anti-Apoptotic	70	143
Tumor Necrosis Factor (TNF) Alpha Inhibitor	43	110
Cardioprotective	29	91
Interleukin-6 Downregulation	34	84
Antiproliferative	46	65
NF-kappaB Inhibitor	36	59
Antidepressive Agents	10	57
Interleukin-1 beta downregulation	30	53
Apoptotic	34	48
Hepatoprotective	25	42
Prophylactic Agents	5	34
Brain-derived neurotrophic factor modulator	8	30
Superoxide Dismutase Up-regulation	16	30
Hypoglycemic Agents	6	28
Malondialdehyde Down-regulation	15	28
Hypolipidemic	6	27
Anti-Anxiety Agents	4	25
Renoprotective	12	24
Vasodilator Agents	4	24
Nrf2 activation	14	23
Chemoprotective Agents	11	22
Cyclooxygenase 2 Inhibitors	13	21
Immunomodulatory	5	20
Neurorestorative	2	20
Anti-metastatic	14	19
Nitric Oxide Inhibitor	10	19
Radioprotective	4	19
Anti-Bacterial Agents	12	18
Antiviral Agents	16	18
Gastrointestinal Agents	8	16
Anti-Fibrotic	7	15
Interleukin-8 downregulation	5	15
Acetylcholinesterase Inhibitor	3	14
Chemotherapeutic	5	14
Antihypertensive Agents	3	13
Interleukin-17 downregulation	3	13
Interleukin-10 upregulation	2	12
Interleukin-5 downregulation	2	11
Anti-Asthmatic Agents	1	10
Anti-collagenase	1	10
Antimutagenic Agents	1	10
Cardiovascular Agents	1	10
Dermatologic Agents	1	10
Genoprotective	1	10
Heme oxygenase-1 up-regulation	5	10
Matrix metalloproteinase-9 (MMP-9) inhibitor	8	10
Nitric Oxide Enhancer	1	10
Osteoprotective	5	10
Chemopreventive	6	9
Angiogenesis Inducing Agents	4	8
Angiogenesis Inhibitors	5	8
Antineoplastic Agents	6	8
Gastroprotective	4	8
Matrix metalloproteinase-2 (MMP-2) inhibitor	5	8
MicroRNA modulator	5	8
Analgesics	4	6
Anticarcinogenic Agents	3	6
Cell cycle arrest	5	6
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	3	6
Neurogenesis	4	6
Chemosensitizer	5	5
Interleukin-18 down-regulation	3	5
Vascular Endothelial Growth Factor Inhibitors	3	5
Wnt/β-catenin signaling pathway modulation	4	5
Autophagy Up-regulation	3	4
Bcl-2 protein down-regulation	4	4
Remyelination	2	4
STAT3 Inhibitor	4	4
Transforming growth factor beta (TGF-β) inhibitor	2	4
Vasoprotective	3	4
Anti-atherogenic	2	3
Chondroprotective	2	3
Enzyme Inhibitors	3	3
Heat Shock Protein Down-Regulation	2	3
Neuritogenic	2	3
Platelet Aggregation Inhibitors	2	3
Postaglandin PGE2 downregulation	2	3
Radiosensitizer	1	3
5-Lipoxygenase Inhibitor	2	2
Anti-Glycation Agents	1	2
Anti-Ulcer Agents	1	2
Anti-thrombotic	1	2
Antimicrobial	2	2
Antioxidant Effects	1	2
Aphrodisiac	1	2
Aromatase Inhibitors	1	2
Bax/Bcl2 ratio: Increase	1	2
Dopaminergic	1	2
HIV Protease Inhibitors	2	2
Heat Shock Protein Inducer	1	2
Insulin Down-Regulation	1	2
Interferon Gamma Reducer	1	2
Interleukin-1 alpha downregulation	1	2
Interleukin-12 downregulation	1	2
Iron Chelating Agents	1	2
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	2
Multidrug Resistance Gene Modulators	1	2
Neurominidase Inhibitor	1	2
Nootropic Agents	2	2
Pancreato Protective Agents	1	2
Regenerative	1	2
STAT3 Activation	1	2
Tumor Suppressor Protein p53 Upregulation	1	2
Vascular Endothelial Growth Factor A Enhancer	1	2
Wnt/β-catenin pathway down-regulation	1	2
Anti-Adipogenic	1	1
Anti-Estrogenic	1	1
Antifungal Agents	1	1
Antinoceceptive	1	1
Antiparasitic Agents	1	1
Caspase-3 Activation	1	1
Caspase-8 activation	1	1
Cholinesterase Inhibitors	1	1
Cyclin D1 Down-Regulation	1	1
Cyclin-Dependent Kinase Inhibitor	1	1
Cyclin-Dependent Kinase Inhibitor: P16	1	1
Cyclooxygenase 1 Inhibitor	1	1
Cytotoxic	1	1
DNA Repair Up-regulation	1	1
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor	1	1
Immunostimulatory	1	1
Interleukin-13 Up-Regulation	1	1
Matrix Metalloproteinase-7 (MMP-7) Inhibitor	1	1
Neuromodulatory	1	1
Neuroplasticity enhancement	1	1
P21 Activation	1	1
Quorum Sensing Inhibition	1	1
Reverse Transcriptase Inhibitors	1	1
SIRT1 Activator	1	1
Secretagogue	1	1
Survivin Down-Regulation	1	1
Telomerase Upregulation	1	1
Vascular Cell Adhesion Molecule-1 Inhibitor	1	1
Vascular Endothelial Growth Factor A Inhibitor	1	1
Viral Hemagglutinin Inhibitor	1	1
interleukin-13 down-regulation	1	1

[+]

Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome.Jul 31, 2024

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Pubmed Data : Metab Brain Dis. 2022 Feb ;37(2):329-341. Epub 2022 Jan 20. PMID: 35050445

Article Published Date : Jan 31, 2022

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Alzheimer's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

[+]

Ginkgolide B mediated alleviation of inflammatory cascades and altered lipid metabolism.Dec 31, 2018

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Pubmed Data : Neuroreport. 2014 Mar 5 ;25(4):267-73. PMID: 24264075

Article Published Date : Mar 04, 2014

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Cerebral Ischemia

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

[+]

Ginkgolide B promotes neuronal differentiation through the Wnt/β-catenin pathway in neural stem cells of the postnatal mammalian subventricular zone.Oct 07, 2018

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Pubmed Data : Acta Pharmacol Sin. 2016 Feb ;37(2):177-86. Epub 2016 Jan 18. PMID: 26775663

Article Published Date : Jan 31, 2016

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Endothelial Dysfunction

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents

[+]

Ginkgolide B reduces atherogenesis and vascular inflammation.Dec 31, 2011

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Pubmed Data : Zhong Yao Cai. 2010 May ;33(5):759-62. PMID: 20873561

Article Published Date : Apr 30, 2010

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Hypertension, Myocardial Ischemia

Pharmacological Actions : Cardioprotective

[+]

Ginkgolide K attenuates neuronal injury after ischemic stroke.Jul 03, 2017

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Pubmed Data : Eur J Pharmacol. 2018 Aug 15 ;833:221-229. Epub 2018 Jun 8. PMID: 29890157

Article Published Date : Aug 14, 2018

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Stroke: Ischemic

Pharmacological Actions : Angiogenesis Inducing Agents

[+]

Ginkgolide K protects SH‑SY5Y cells against oxygen‑glucose deprivation‑induced injury by inhibiting the p38 and JNK signaling pathways.Aug 31, 2018

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Pubmed Data : Bratisl Lek Listy. 2017 ;118(11):676-683. PMID: 29216724

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Pharmacological inhibition of SUMO-1 with ginkgolic acid alleviates cardiac fibrosis induced by myocardial infarction.Apr 14, 2018

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Pubmed Data : Toxicol Appl Pharmacol. 2018 Apr 15 ;345:1-9. Epub 2018 Mar 7. PMID: 29524504

Article Published Date : Apr 14, 2018

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Myocardial Fibrosis , Myocardial Infarction

Pharmacological Actions : Cardioprotective

[+]

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Pubmed Data : Chin Med. 2020 Nov 19 ;15(1):122. Epub 2020 Nov 19. PMID: 33292377

Article Published Date : Nov 18, 2020

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Liver Injury: Ischemia/reperfusion

Pharmacological Actions : Hepatoprotective

[+]

Protective effects of Ginkgo biloba extract EGb 761 against noise trauma-induced hearing loss and tinnitus development.Dec 31, 2013

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Pubmed Data : Molecules. 2022 Aug 31 ;27(17). Epub 2022 Aug 31. PMID: 36080365

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Pubmed Data : Neural Regen Res. 2017 Aug ;12(8):1287-1293. PMID: 28966643

Article Published Date : Jul 31, 2017

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Acrylamide-induced toxicity

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Hippocampus Regeneration, Plant Extracts

Problem Substances : Acrylamide

[+]

These findings suggest that G. biloba and dandelion extracts confer protective effects against TAA-induced liver damage.May 31, 2025

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Pubmed Data : Toxicol Res (Camb). 2025 Jun ;14(3):tfaf075. Epub 2025 Jun 8. PMID: 40491504

Article Published Date : May 31, 2025

Study Type : Animal Study

Additional Links

Substances : Dandelion , Ginkgo biloba

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective

[+]

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Pubmed Data : Adv Pharm Bull. 2018 Nov ;8(4):575-590. Epub 2018 Nov 29. PMID: 30607330

Article Published Date : Oct 31, 2018

Study Type : Review

Additional Links

Substances : Cannabis, Cranberry, Frankincense, Ginger, Ginkgo biloba, Ginseng, Grape, Kava Kava, Nigella sativa (aka Black Seed), Saffron, St. Johns Wort, Turmeric, Valerian

Diseases : Multiple Sclerosis

[+]

Anti-influenza virus activity of Ginkgo biloba leaf extracts.Nov 21, 2012

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Pubmed Data : J Nat Med. 2012 Nov 22. Epub 2012 Nov 22. PMID: 23179317

Article Published Date : Nov 21, 2012

Study Type : In Vitro Study

Additional Links

Substances : Ginkgo biloba

Diseases : H3N2 Infection , Influenza A

Pharmacological Actions : Viral Hemagglutinin Inhibitor

[+]

Anti-neoplastic effect of ginkgolide C through modulating c-Met phosphorylation in hepatocellular carcinoma cells.Nov 04, 2020

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Artemisinin-Ginkgo biloba extract combination therapy for Plasmodium yoelii.Jan 31, 2021

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Pubmed Data : Parasitol Int. 2021 Feb ;80:102226. Epub 2020 Nov 1. PMID: 33137498

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Pubmed Data : Free Radic Res. 2014 Oct ;48(10):1206-17. PMID: 25039303

Article Published Date : Sep 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Ginkgo biloba

Diseases : Hypoxia, Inflammation, Obesity, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Bilobalide attenuates lipopolysaccharide‑induced HepG2 cell injury.Dec 31, 2023

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Pubmed Data : Exp Ther Med. 2024 Jan ;27(1):24. Epub 2023 Nov 22. PMID: 38125341

Article Published Date : Dec 31, 2023

Study Type : In Vitro Study

Additional Links

Substances : Ginkgo biloba

Diseases : Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

[+]

Bilobalide induces apoptosis in 3T3-L1 mature adipocytes through ROS.Sep 01, 2023

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Pubmed Data : Molecules. 2023 Sep 2 ;28(17). Epub 2023 Sep 2. PMID: 37687239

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Pubmed Data : Am J Chin Med. 2024 ;52(4):1053-1086. Epub 2024 Jun 21. PMID: 38904550

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Pubmed Data : Neurochem Res. 2017 Feb ;42(2):606-614. Epub 2016 Nov 25. PMID: 27885578

Article Published Date : Jan 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Ginkgo biloba

Diseases : Fluoride Toxicity

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts

Problem Substances : Sodium Fluoride

[+]

Enhanced neuroprotective effects of Panax ginseng G115 and Ginkgo biloba GK501 combinations in vitro models of excitotoxicity.Nov 21, 2019

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Pubmed Data : Iran J Basic Med Sci. 2016 Nov ;19(11):1245-1250. PMID: 27917282

Article Published Date : Oct 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Ginkgo biloba

Diseases : Kidney Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Ginkgetin prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation.Dec 31, 2018

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Pubmed Data : Pharmacol Res. 2019 Jan ;139:325-336. Epub 2018 Nov 22. PMID: 30472463

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Pubmed Data : Food Chem Toxicol. 2020 Nov ;145:111642. Epub 2020 Aug 9. PMID: 32783998

Article Published Date : Oct 31, 2020

Study Type : Review

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Substances : Ginkgo biloba

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation

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Ginkgo biloba and its chemical components in the management of Alzheimer's disease.Dec 31, 2023

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Pubmed Data : Am J Chin Med. 2024 ;52(3):625-666. Epub 2024 Apr 24. PMID: 38654507

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Pubmed Data : Curr Opin Ophthalmol. 2017 Dec 4. Epub 2017 Dec 4. PMID: 29206653

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Pubmed Data : Neuropsychiatr Dis Treat. 2023 ;19:647-660. Epub 2023 Mar 23. PMID: 36994422

Article Published Date : Dec 31, 2022

Study Type : Review

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Substances : Ginkgo biloba

Diseases : Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

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Ginkgo biloba extract EGb 761-induced upregulation of LincRNA-p21 inhibits colorectal cancer metastasis.Oct 30, 2017

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Pubmed Data : PLoS One. 2019 ;14(12):e0225761. Epub 2019 Dec 2. PMID: 31790465

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Pubmed Data : J Int Adv Otol. 2015 Dec ;11(3):179-82. PMID: 26915145

Article Published Date : Nov 30, 2015

Study Type : In Vitro Study

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Substances : Ginkgo biloba

Diseases : Chemotherapy-Induced Toxicity: Gentamicin

Pharmacological Actions : Chemoprotective Agents

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Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic

Additional Keywords : Plant Extracts

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Ginkgo biloba in the aging process: a narrative review. Mar 08, 2022

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Pubmed Data : Antioxidants (Basel). 2022 Mar 9 ;11(3). Epub 2022 Mar 9. PMID: 35326176

Article Published Date : Mar 08, 2022

Study Type : Review

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Substances : Ginkgo biloba

Diseases : Aging, Cancers: All, Cardiovascular Diseases, Neurodegenerative Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Ginkgo biloba in the management of the COVID-19 severity.Jun 06, 2022

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Pubmed Data : Plants (Basel). 2019 Nov 29 ;8(12). Epub 2019 Nov 29. PMID: 31795413

Article Published Date : Nov 28, 2019

Study Type : In Vitro Study

Additional Links

Substances : Ginkgo biloba

Diseases : Chemically-Induced Liver Damage, DNA damage, Oxidative Stress, Pesticide Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Paraquat

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Ginkgo biloba leaf extract reverses amyloid beta-peptide-induced isoprostane production in rat brain in vitro.Oct 31, 2006

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Pubmed Data : Planta Med. 2006 Nov ;72(14):1296-9. Epub 2006 Oct 4. PMID: 17022004

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Pubmed Data : Exp Ther Med. 2020 Apr ;19(4):2949-2956. Epub 2020 Feb 27. PMID: 32256780

Article Published Date : Mar 31, 2020

Study Type : In Vitro Study

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Substances : Ginkgo biloba

Diseases : Kidney Cancer

Pharmacological Actions : Antiproliferative

[+]

Ginkgolic acid inhibits the invasiveness of colon cancer cells through AMPK activation.Oct 31, 2017

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Pubmed Data : Oncol Lett. 2017 Nov ;14(5):5831-5838. Epub 2017 Sep 15. PMID: 29113214

Article Published Date : Oct 31, 2017

Study Type : In Vitro Study

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Substances : Ginkgo biloba

Diseases : Colon Cancer

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

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Pubmed Data : J Med Food. 2021 Aug ;24(8):806-816. Epub 2021 Aug 11. PMID: 34382859

Article Published Date : Jul 31, 2021

Study Type : In Vitro Study

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Substances : Ginkgo biloba

Diseases : Nasopharyngeal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, NF-kappaB Inhibitor

[+]

Ginkgolic acid suppresses the invasion of HepG2 cells.Dec 31, 2018

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Ginkgolide B inhibits hydrogen peroxide‑induced apoptosis and attenuates cytotoxicity via activating the PI3K/Akt/mTOR signaling pathway in H9c2 cells.Jun 30, 2020

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Pubmed Data : Mol Med Rep. 2020 Jul ;22(1):310-316. Epub 2020 Apr 30. PMID: 32377729

Article Published Date : Jun 30, 2020

Study Type : In Vitro Study

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Substances : Ginkgo biloba

Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Cardioprotective

[+]

Pubmed Data : Eur J Pharmacol. 2010 Nov 25 ;647(1-3):48-54. Epub 2010 Aug 13. PMID: 20709055

Article Published Date : Nov 24, 2010

Study Type : In Vitro Study

Additional Links

Substances : Ginkgo biloba

Diseases : Alzheimer's Disease

Pharmacological Actions : Anti-Apoptotic, Brain-derived neurotrophic factor modulator, Neuroprotective Agents

[+]

Ginkgolide B protects neurons from ischemic injury.Sep 30, 2015

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Pubmed Data : Saudi Pharm J. 2018 Dec ;26(8):1178-1184. Epub 2018 Jul 20. PMID: 30532639

Article Published Date : Nov 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Ginkgo biloba

Diseases : Fatty Liver

Pharmacological Actions : Hepatoprotective, Hypolipidemic

[+]

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Isoginkgetin, a natural biflavonoid proteasome inhibitor, sensitizes cancer cells to apoptosis.May 14, 2019

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Pubmed Data : Mol Cell Biol. 2019 May 15 ;39(10). Epub 2019 Apr 30. PMID: 30910794

Article Published Date : May 14, 2019

Study Type : In Vitro Study

Additional Links

Substances : Ginkgo biloba

Diseases : Multiple Myeloma

Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor

[+]

Isoginkgetin-loaded reactive oxygen species scavenging nanoparticles ameliorate intervertebral disc degeneration.Mar 20, 2023

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Pubmed Data : Int Psychogeriatr. 2012 Aug ;24 Suppl 1:S18-20. PMID: 22784423

Article Published Date : Jul 31, 2012

Study Type : Review

Additional Links

Substances : Ginkgo biloba

Diseases : Aging: Brain , Mitochondrial Dysfunction , Oxidative Stress

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts

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View the Evidence: 662 Abstracts with Ginkgo biloba Research

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Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome.Jul 31, 2024

Ginkgolide B exerted protective effects against cisplatin-induced ototoxicity in vitro and in vivo.Apr 30, 2015

Ginkgolide B facilitates glutamate exocytosis from rat hippocampal nerve terminals.May 08, 2005

Ginkgolide B has protective effects on cerebral injury by inhibiting the inflammation induced by ischemia/reperfusion injury.Mar 31, 2010

Ginkgolide B improved postoperative cognitive dysfunction.Jul 17, 2022

Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer's disease.Jan 31, 2022

Ginkgolide B mediated alleviation of inflammatory cascades and altered lipid metabolism.Dec 31, 2018

Ginkgolide B monotherapy reverses osteoporosis by regulating oxidative stress-mediated bone homeostasis.May 19, 2021

Ginkgolide B preconditioning protects neurons against ischaemia-induced apoptosis.Dec 31, 2008

Ginkgolide B prevents cathepsin-mediated cell death following cerebral ischemia/reperfusion injury.Mar 04, 2014

Ginkgolide B promotes neuronal differentiation through the Wnt/β-catenin pathway in neural stem cells of the postnatal mammalian subventricular zone.Oct 07, 2018

Ginkgolide B promotes osteoblast differentiation via activation of canonical Wnt signalling and alleviates osteoporosis.Jul 31, 2019

Ginkgolide B promotes spontaneous recovery and enhances endogenous netrin-1 after neonatal hypoxic-ischemic brain damage.Sep 28, 2023

Ginkgolide B protects against ischemic strokeAug 31, 2016

Ginkgolide B protects against ischemic stroke.Dec 31, 2021

Ginkgolide B protects human pulmonary alveolar epithelial A549 cells from lipopolysaccharide-induced inflammatory responses.Oct 31, 2020

Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation.Jan 31, 2016

Ginkgolide B reduces atherogenesis and vascular inflammation.Dec 31, 2011

Ginkgolide B reduces inflammatory protein expression in oxidized low-density lipoprotein-stimulated human vascular endothelial cells.May 31, 2011

Ginkgolide B reduces neuronal cell apoptosis in the hemorrhagic brain.Oct 10, 2011

Ginkgolide B reduces neuronal cell apoptosis in the traumatic rat brain.Nov 30, 2012

Ginkgolide B reduces the degradation of membrane phospholipids to prevent ischemia/reperfusion myocardial injury.Dec 31, 2014

Ginkgolide B targets and inhibits creatine kinase B to regulate the CCT/TRiC-SK1 axis and exerts pro-angiogenic activity in middle cerebral artery occlusion.May 31, 2022

Ginkgolide B treatment regulated intestinal flora to improve high-fat diet induced atherosclerosis.Jan 31, 2021

Ginkgolide B treatment restored the bone-to-muscle endocrine axis to reverse aging-related declines in muscle regeneration.May 31, 2023

Ginkgolide BN 52021 protects against hemorrhagic shock-induced renal injury.Dec 31, 1994

Ginkgolide B‑mediated therapeutic effects on perioperative neurocognitive dysfunction.Jun 30, 2021

Ginkgolide C alleviates myocardial ischemia/reperfusion-induced inflammatory injury.Dec 31, 2017

Ginkgolide C attenuated Western diet-induced non-alcoholic fatty liver disease.Jun 30, 2024

Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis.May 09, 2024

Ginkgolide can improve the hemodynamic conditions and oxygen metabolism of myocardial ischemic dogs.Apr 30, 2010

Ginkgolide K attenuates neuronal injury after ischemic stroke.Jul 03, 2017

Ginkgolide K delays the progression of osteoarthritis.Jul 31, 2023

Ginkgolide K is revealed as a promising therapeutic agent to ameliorate ER stress for treating cardiovascular diseases.Jul 31, 2016

Ginkgolide K promotes angiogenesis in a middle cerebral artery occlusion model.Aug 14, 2018

Ginkgolide K protects SH‑SY5Y cells against oxygen‑glucose deprivation‑induced injury by inhibiting the p38 and JNK signaling pathways.Aug 31, 2018

Ginkgolide-A attenuates bacterial translocation through activating PXR and improving antimicrobial peptide Reg 3A in experimental cirrhosis.Sep 14, 2020

Hepatoprotective effect of Ginkgo biloba extract against methotrexate-induced hepatotoxicity.Dec 20, 2020

Highly stabilized nanocrystals delivering Ginkgolide B in protecting against the Parkinson's disease.Mar 14, 2020

Hyperbaric oxygen and Ginkgo biloba extract improved cognitive and memory capacity in a rat model of Alzheimer's disease.Dec 31, 1969

In vivo protective effects of Ginkgo biloba L. leaf extract against hydrogen peroxide toxicity: cytogenetic and biochemical evaluation.Dec 13, 2019

Inhibition by Egb761 of the effect of cellphone radiation on the male reproductive system.Dec 31, 2016

Inhibitory effect of bilobalide on Staphylococcus aureus.Oct 03, 2023

Inhibitory effect of ginkgolide B on angiogenesis in chronic inflammation.Mar 31, 2005

Isoginkgetin attenuates endoplasmic reticulum stress-induced autophagy of brain after ischemic reperfusion injury.Nov 16, 2021

Isoginkgetin, a potential CDK6 inhibitor, suppresses SLC2A1/GLUT1 enhancer activity to induce AMPK-ULK1-mediated cytotoxic autophagy in hepatocellular carcinoma.Sep 12, 2022

L-carnitine and ginkgo biloba extract exhibits a protective agent in an animal model of bleomycin-induced lung fibrosis Jun 01, 2002

L-carnitine and Ginkgo biloba supplementation in vivo ameliorates HCD-induced steatohepatitis and dyslipidemia.Apr 22, 2024

Local administration of ginkgolide B using a hyaluronan-based hydrogel improves wound healing in diabetes.Dec 31, 2021

Long-term treatment with EGb 761 may reduce cerebral Aβ pathology by inhibiting β-secretase activity and Aβ aggregation.Apr 30, 2015

Mechanism and dose-effect of Ginkgolide B on severe acute pancreatitis.May 06, 2011

Mitochondria protection with ginkgolide B-loaded polymeric nanocapsules prevents diethylnitrosamine-induced hepatocarcinoma.Feb 28, 2014

Modulation of bleomycin-induced oxidative stress and pulmonary fibrosis by ginkgetin.Dec 31, 2022

Multiple mechanistic models reveal the neuroprotective effects of diterpene ginkgolides against astrocyte-mediated demyelination.Dec 31, 2021

Myocardium-protective effects of Ginkgo biloba extract (EGb 761) in old rats against acute isobaric hypoxia. An electron microscopic morphometric study. I. Protection of cardiomyocytes.Dec 31, 1995

Natural product, bilobalide, improves joint health in rabbits with osteoarthritis.Dec 31, 2021

Neuroprotection by bilobalide in ischemia: improvement of mitochondrial function.Jun 30, 2013

Neuroprotective effect of aspirin combined with ginkgolide injection on cerebral ischemic stroke.May 31, 2021

Neuroprotective effect of ginkgetin in experimental cerebral ischemia/reperfusion.Sep 30, 2019

Neuroprotective effect of ginkgolide K against acute ischemic stroke on middle cerebral ischemia.Dec 31, 2011

Neuroprotective effect of ginkgolide K on glutamate-induced cytotoxicity in PC 12 cells.Dec 31, 2011

Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury.Sep 25, 2014

Neuroprotective effects of Ginkgolide B in focal cerebral ischemia.Jan 14, 2021

Orally administered Ginkgolide C alleviates MPTP-induced neurodegeneration.Oct 08, 2024

Orally administered ginkgolide C attenuates DSS-induced colitis.Nov 22, 2022

PAF receptor antagonist Ginkgolide B inhibits tumourigenesis and angiogenesis in colitis-associated cancer.Dec 31, 2014

Pharmacological inhibition of SUMO-1 with ginkgolic acid alleviates cardiac fibrosis induced by myocardial infarction.Apr 14, 2018

Pharmacotherapeutic potential of ginkgetin against polystyrene microplastics-instigated testicular toxicity.Jan 31, 2024

Prevention of bleomycin-induced pulmonary inflammation and fibrosis by bilobalide.Dec 31, 2022

Preventive effects of ginkgo-extract EGb 761® on noise trauma-induced cochlear synaptopathy.Jul 21, 2022

Protective effect of bilobalide on learning and memory impairment in rats with vascular dementia.Aug 31, 2013

Protective effect of ginkgolide B against acute spinal cord injury.Feb 28, 2013

Ginkgo biloba

View the Evidence:
662 Abstracts with Ginkgo biloba Research