Glycyrrhizin

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47 Diseases Researched for Glycyrrhizin
NameACCKFocus
Psoriasis120Locked
Addison's Disease110Locked
Stroke: Ischemic110Locked
Vitiligo110Locked
Inflammation68Locked
Coronavirus Infection55Locked
Liver Damage24Locked
Nonalcoholic fatty liver disease (NAFLD)24Locked
Oxidative Stress24Locked
Brain Inflammation 23Locked
Encephalomyelitis23Locked
Hepatitis C23Locked
Lipopolysaccharide-Induced Toxicity23Locked
Liver Injury: Ischemia/reperfusion 23Locked
Acetaminophen (Tylenol) Toxicity 12Locked
Atopic Dermatitis12Locked
Chemotherapy and Radiation Toxicity12Locked
Chemotherapy-Induced Toxicity: Doxorubicin12Locked
Cognitive Decline/Dysfunction12Locked
Colorectal Cancer12Locked
Coronavirus Disease22Locked
Dyslipidemias12Locked
Fatty Liver12Locked
H5N1 Infection22Locked
Hepatitis: Lectin-Induced (concanavalin)12Locked
Influenza A22Locked
Insulin Resistance12Locked
Iron Poisoning12Locked
Liver Damage: Drug-Induced12Locked
Metabolic Diseases12Locked
Multiple Sclerosis12Locked
Obesity12Locked
Venous Thrombosis12Locked
Aging11Locked
Allergic Rhinitis11Locked
Carcinoma: Non-Small-Cell Lung11Locked
Degenerative Disk Disease11Locked
Herpex Simplex Virus11Locked
Liver Cancer11Locked
Melanoma11Locked
Osteoporosis11Locked
Periodontal Diseases11Locked
Periodontitis11Locked
Pseudomonas aeruginosa11Locked
Pseudorabies Herpesvirus11Locked
Skin Diseases: Photo-Aging11Locked
Traumatic Brain Injury11Locked
34 Pharmacological Actions Researched for Glycyrrhizin
NameACCKFocus
Anti-Inflammatory Agents2037Locked
Neuroprotective Agents415Locked
Hepatoprotective713Locked
CYP3A enzyme induction110Locked
Antiviral Agents99Locked
Interleukin-6 Downregulation59Locked
NF-kappaB Inhibitor78Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor47Locked
Interleukin-1 beta downregulation45Locked
Antioxidants34Locked
Antiproliferative 34Locked
Nrf2 activation23Locked
Apoptotic22Locked
Cardioprotective12Locked
Chemopreventive12Locked
Chemoprotective Agents12Locked
Heme oxygenase-1 up-regulation12Locked
Hypoglycemic Agents12Locked
Hypolipidemic12Locked
Immunomodulatory22Locked
Insulin Sensitizers12Locked
Interferon Gamma Reducer12Locked
Interleukin-17 downregulation12Locked
MicroRNA modulator12Locked
Radioprotective12Locked
Analgesics11Locked
Anti-Apoptotic11Locked
Anti-Bacterial Agents11Locked
Anti-metastatic11Locked
Cell cycle arrest11Locked
Cyclooxygenase 2 Inhibitors11Locked
Immunostimulatory11Locked
Osteoprotective 11Locked
Postaglandin PGE2 downregulation 11Locked
Related Topics

Glycyrrhizin is a Sub of the following Topic

View the Evidence:
60 Abstracts with Glycyrrhizin Research

[+]

Compound glycyrrhizin plus conventional therapy for psoriasis vulgaris.Dec 31, 2016

Pubmed Data : Curr Med Res Opin. 2017 02 ;33(2):279-287. Epub 2016 Nov 10. PMID: 27786567
Article Published Date : Dec 31, 2016
Study Type : Meta Analysis, Review
Additional Links
Substances : Glycyrrhizin
Diseases : Psoriasis
[+]

Administration of glycyrrhizin resulted in a modest induction of CYP3A that was clinically relevant according to the bioequivalence analysis.Jul 31, 2010

Pubmed Data : Eur J Clin Pharmacol. 2010 Aug ;66(8):805-810. Epub 2010 Apr 15. PMID: 20393696
Article Published Date : Jul 31, 2010
Study Type : Human Study
Additional Links
Substances : Glycyrrhizin
Pharmacological Actions : Anti-Inflammatory Agents, CYP3A enzyme induction
[+]

Glycyrrhizin and ultraviolet B light therapy improved active-stage generalized vitiligo.Jul 24, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Braz J Med Biol Res. 2016 Jul 25 ;49(8). PMID: 27464024
Article Published Date : Jul 24, 2016
Study Type : Human Study
Additional Links
Substances : Glycyrrhizin
Diseases : Vitiligo
Therapeutic Actions : Integrative Medicine, Light Therapy
[+]

Glycyrrhizin prevents hemorrhagic transformation and improves neurological outcome in ischemic stroke with delayed thrombolysis.Dec 23, 2019

Pubmed Data : Transl Stroke Res. 2019 Dec 24. Epub 2019 Dec 24. PMID: 31872339
Article Published Date : Dec 23, 2019
Study Type : Animal Study, Human Study
Additional Links
Substances : Glycyrrhizin
Diseases : Stroke: Ischemic
Pharmacological Actions : Neuroprotective Agents
[+]

Liquorice and soy sauce has been reported a life-saving concoction in a patient with Addison's disease.Jun 30, 2007

Pubmed Data : Ann Clin Biochem. 2007 Jul ;44(Pt 4):397-9. PMID: 17594790
Article Published Date : Jun 30, 2007
Study Type : Human Study
Additional Links
Substances : Glycyrrhizin, Soy Sauce
Diseases : Addison's Disease
[+]

[Extraction of miRNA from Glycyrrhiza uralensis Decoction and Its Effect on Immune Cells].Jun 30, 2015

Pubmed Data : Zhong Yao Cai. 2015 Jul ;38(7):1449-53. PMID: 26946842
Article Published Date : Jun 30, 2015
Study Type : Human Study
Additional Links
Substances : Glycyrrhizin
Additional Keywords : MicroRNA, Plant Extracts
[+]

"A glycyrrhizin-containing preparation reduces hepatic steatosis induced by hepatitis C virus protein and iron in mice."Apr 01, 2011

Pubmed Data : Liver Int. 2011 Apr ;31(4):552-60. Epub 2011 Feb 15. PMID: 21382166
Article Published Date : Apr 01, 2011
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Fatty Liver, Hepatitis C, Iron Poisoning, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Cardioprotective action of glycyrrhizin on diabetic rats with myocardial remodeling.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Healthc Eng. 2021 ;2021:6343677. Epub 2021 Aug 31. PMID: 34512937
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Cardiovascular Diseases, Diabetic Complications
Pharmacological Actions : Cardioprotective
[+]

Cardioprotective effect of glycyrrhizin on myocardial remodelling in diabetes.Apr 12, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2021 Apr 13 ;11(4). Epub 2021 Apr 13. PMID: 33924458
Article Published Date : Apr 12, 2021
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Diabetic Complications
Pharmacological Actions : Cardioprotective
[+]

Glycyrrhizic acid protects against non-alcoholic fatty liver disease in mice due to regulation of genes involved in lipid, glucose homeostasis and insulin sensitivity.Jul 05, 2017

Pubmed Data : Eur J Pharmacol. 2017 Jul 5 ;806:75-82. Epub 2017 Apr 14. PMID: 28414056
Article Published Date : Jul 05, 2017
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Dyslipidemias, Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic, Insulin Sensitizers
[+]

Glycyrrhizin alleviates Con A-induced hepatitis.Jan 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Feb ;110:692-699. Epub 2018 Dec 12. PMID: 30553196
Article Published Date : Jan 31, 2019
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Hepatitis: Lectin-Induced (concanavalin)
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interferon Gamma Reducer, Interleukin-17 downregulation, Interleukin-6 Downregulation
Problem Substances : Concanavalin A
[+]

Glycyrrhizin alleviates non-alcoholic steatohepatitis.Jun 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Metab Dispos. 2018 Jun 29. Epub 2018 Jun 29. PMID: 29959134
Article Published Date : Jun 28, 2018
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
[+]

Glycyrrhizin ameliorates atopic dermatitis-like symptoms.Apr 23, 2018

Pubmed Data : Int Immunopharmacol. 2018 Apr 24 ;60:9-17. Epub 2018 Apr 24. PMID: 29702284
Article Published Date : Apr 23, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Atopic Dermatitis
[+]

Glycyrrhizin attenuates carcinogenesis by inhibiting the inflammatory response in a murine model of colorectal cancer.Mar 04, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2021 Mar 5 ;22(5). Epub 2021 Mar 5. PMID: 33807620
Article Published Date : Mar 04, 2021
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Colorectal Cancer, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Chemopreventive, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Glycyrrhizin attenuates Salmonella typhimurium-induced tissue injury.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Vet Sci. 2021 ;8:648698. Epub 2021 Jun 22. PMID: 34239908
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Dysbiosis, Salmonella Infections
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents, Interferon Gamma Reducer, Interleukin-10 upregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Glycyrrhizin could be a potential candidate for the prevention of doxorubicin induced cardiotoxicity.Dec 31, 2019

Pubmed Data : Toxicology. 2020 08 ;441:152508. Epub 2020 Jun 7. PMID: 32525084
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress
Pharmacological Actions : Cardioprotective, Chemoprotective Agents
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Glycyrrhizin improves inflammation and apoptosis via suppressing HMGB1 and PI3K/mTOR pathway in lipopolysaccharide-induced acute liver injury.May 31, 2020

Pubmed Data : Eur Rev Med Pharmacol Sci. 2020 Jun ;24(12):7122-7130. PMID: 32633407
Article Published Date : May 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
[+]

Glycyrrhizin improves the pathogenesis of psoriasis.May 26, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Immunol. 2021 May 27 ;22(1):34. Epub 2021 May 27. PMID: 34044769
Article Published Date : May 26, 2021
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Psoriasis
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-17 downregulation
[+]

Glycyrrhizin mitigates radiation‐induced acute lung injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2020 Jan ;24(1):214-226. Epub 2019 Oct 27. PMID: 31657123
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Chemotherapy and Radiation Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Radioprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Glycyrrhizin modulates chronic seizures-induced memory dysfunction.Aug 30, 2021

Pubmed Data : ACS Chem Neurosci. 2021 Aug 31. Epub 2021 Aug 31. PMID: 34463468
Article Published Date : Aug 30, 2021
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Memory Disorders, Seizures
Pharmacological Actions : Neuroprotective Agents
[+]

Glycyrrhizin possesses therapeutic potential against hepatocellular damage in metabolic syndrome. Oct 31, 2015

Pubmed Data : Mol Cell Biochem. 2015 Nov ;409(1-2):177-89. Epub 2015 Sep 23. PMID: 26400710
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Liver Damage, Metabolic Diseases
Pharmacological Actions : Hepatoprotective
[+]

Glycyrrhizin protects mice against experimental autoimmune encephalomyelitis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2018 ;9:1518. Epub 2018 Jul 2. PMID: 30013568
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Brain Inflammation , Encephalomyelitis, Multiple Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

N-acetylcysteine and glycyrrhizin combination: Benefit outcome in a murine model of acetaminophen-induced liver failure.Sep 26, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Hepatol. 2020 Sep 27 ;12(9):596-618. PMID: 33033567
Article Published Date : Sep 26, 2020
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin, NAC (N-acetyl-L-cysteine)
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Pre-treatment with glycyrrhizin inhibited venous thrombosis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Vasc Dis. 2016 ;9(2):95-101. Epub 2016 Apr 26. PMID: 27375802
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Venous Thrombosis
Pharmacological Actions : MicroRNA modulator
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Spirulina and glycyrrhizin has a potential role in reversing cognitive dysfunctions associated with aging and obesity.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Indian J Pharmacol. 2015 Jan-Feb;47(1):39-44. PMID: 25821309
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin, Spirulina
Diseases : Cognitive Decline/Dysfunction, Obesity
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Natural Substance Synergy
Problem Substances : Monosodium Glutamate (MSG)
[+]

The protective effect of glycyrrhizin on hepatic ischemia-reperfusion injury in rats and possible related signal pathway.Aug 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2020 Sep ;23(9):1232-1238. PMID: 32963746
Article Published Date : Aug 31, 2020
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome? Jan 09, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Ther. 2020 10 ;214:107618. Epub 2020 Jun 24. PMID: 32592716
Article Published Date : Jan 09, 2020
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

"Glycyrrhizic acid (GA), a triterpenoid saponin glycoside alleviates ultraviolet-B irradiation-induced photoaging in human dermal fibroblasts."May 14, 2012

Pubmed Data : Phytomedicine. 2012 May 15 ;19(7):658-64. Epub 2012 Apr 18. PMID: 22516896
Article Published Date : May 14, 2012
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin, Licorice
Diseases : Aging, Skin Diseases: Photo-Aging
Therapeutic Actions : Sunlight exposure
Pharmacological Actions : NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

"Glycyrrhizin exerts antioxidative effects in H5N1 influenza A virus-infected cells and inhibits virus replication and pro-inflammatory gene expression."Jan 01, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2011 ;6(5):e19705. Epub 2011 May 17. PMID: 21611183
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : H5N1 Infection, Influenza A
Pharmacological Actions : Antioxidants, Antiviral Agents, Cell cycle arrest, NF-kappaB Inhibitor
[+]

A review of natural products, their effects on SARS-CoV-2 and their utility as lead compounds in the discovery of drugs for the treatment of COVID-19.Dec 01, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Chem Res. 2021 Dec 2:1-12. Epub 2021 Dec 2. PMID: 34873386
Article Published Date : Dec 01, 2021
Study Type : Review
Additional Links
Substances : Baicalein, Flavonoids, Glycyrrhizin, Kaempferol, Polyphenols, Quercetin
Diseases : Coronavirus Infection
Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents
[+]

Anti-inflammatory effect of glycyrrhizin with Equisetum arvense extract.Mar 31, 2021

Pubmed Data : Odontology. 2021 Apr ;109(2):464-473. Epub 2020 Nov 3. PMID: 33141307
Article Published Date : Mar 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin, Horsetail
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Periodontal Diseases
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

Beneficial effects of glycyrrhizin in chronic periodontitis through the inhibition of inflammatory response.Jun 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Dose Response. 2020 Jul-Sep;18(3):1559325820952660. Epub 2020 Sep 10. PMID: 32963505
Article Published Date : Jun 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Can antiviral activity of licorice help fight COVID-19 infection? Jan 07, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2021 06 8 ;11(6). Epub 2021 Jun 8. PMID: 34201172
Article Published Date : Jan 07, 2021
Study Type : Review
Additional Links
Substances : Glycyrrhizin
Diseases : Coronavirus Infection
Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents
[+]

Diammonium glycyrrhizin inhibits pseudorabies herpesvirus infection. Feb 01, 2010

Pubmed Data : Antiviral Res. 2010 Feb ;85(2):346-53. Epub 2009 Oct 30. PMID: 19879899
Article Published Date : Feb 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Pseudorabies Herpesvirus
Pharmacological Actions : Antiviral Agents, Apoptotic
Additional Keywords : Plant Extracts
[+]

Effects of glycyrrhizin on multi-drug tesistant Pseudomonas aeruginosa.Sep 17, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pathogens. 2020 Sep 18 ;9(9). Epub 2020 Sep 18. PMID: 32962036
Article Published Date : Sep 17, 2020
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Pseudomonas aeruginosa
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation
[+]

Glycyrrhizic acid and its hydrolyzed metabolite 18β-glycyrrhetinic acid as specific ligands for targeting nanosystems in the treatment of liver cancer.Oct 25, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceutics. 2021 Oct 26 ;13(11). Epub 2021 Oct 26. PMID: 34834206
Article Published Date : Oct 25, 2021
Study Type : In Vitro Study
Additional Links
Substances : 18β-Glycyrrhetinic Acid, Glycyrrhizin
Diseases : Liver Cancer
Pharmacological Actions : Chemotherapeutic
[+]

Glycyrrhizic acid can be used as a potential COVID-19 treatment.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:707205. Epub 2021 Jul 9. PMID: 34305613
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Glycyrrhizic acid facilitates anti-tumor immunity by attenuating Tregs and MDSCs: An immunotherapeutic approach.Sep 01, 2020

Pubmed Data : Int Immunopharmacol. 2020 Sep 2 ;88:106932. Epub 2020 Sep 2. PMID: 32890791
Article Published Date : Sep 01, 2020
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Melanoma
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Immunomodulatory, Postaglandin PGE2 downregulation
[+]

Glycyrrhizic acid-induced differentiation repressed stemness in hepatocellular carcinoma by targeting c-Jun N-terminal Kinase 1.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Oncol. 2019 ;9:1431. Epub 2020 Jan 9. PMID: 31998631
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Cancer Stem Cells
[+]

Glycyrrhizin affects monocyte migration and apoptosis by blocking HMGB1 signaling.Mar 31, 2018

Pubmed Data : Mol Med Rep. 2018 Apr ;17(4):5970-5975. Epub 2018 Feb 13. PMID: 29436639
Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Glycyrrhizin attenuates hepatic ischemia-reperfusion injury.Feb 28, 2019

Pubmed Data : Int Immunopharmacol. 2019 Mar ;68:145-155. Epub 2019 Jan 8. PMID: 30634142
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation
[+]

Glycyrrhizin effectively inhibits SARS-CoV-2 replication.Apr 01, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Viruses. 2021 Apr 2 ;13(4). Epub 2021 Apr 2. PMID: 33918301
Article Published Date : Apr 01, 2021
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Glycyrrhizin exhibits antiviral effects agent against Hepatitis C Virus.Jan 01, 2011

Pubmed Data : J Transl Med. 2011 ;9:112. Epub 2011 Jul 18. PMID: 21762538
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Hepatitis C
Pharmacological Actions : Antiviral Agents
Additional Keywords : Drug Synergy
[+]

Glycyrrhizin improved the neurological function recovery, reduced the lesion volume, and inhibited the release and expression of HMGB1 after TBI.Jan 25, 2018

Pubmed Data : Biochem Biophys Res Commun. 2018 02 26 ;497(1):430-436. Epub 2018 Feb 12. PMID: 29448108
Article Published Date : Jan 25, 2018
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

Glycyrrhizin inhibits highly pathogenic H5N1 influenza A virus-associated adverse cellular changes.Nov 01, 2010

Pubmed Data : Med Microbiol Immunol. 2010 Nov ;199(4):291-7. Epub 2010 Apr 13. PMID: 20386921
Article Published Date : Nov 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : H5N1 Infection, Influenza A
Pharmacological Actions : Apoptotic, Interleukin-6 Downregulation
[+]

Glycyrrhizin inhibits porcine epidemic diarrhea virus infection (coronaviridiae) and attenuates the proinflammatory responses by inhibition of high mobility group box-1 protein.Jun 01, 2017

Pubmed Data : Arch Virol. 2017 Jun ;162(6):1467-1476. Epub 2017 Feb 7. PMID: 28175983
Article Published Date : Jun 01, 2017
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Coronavirus Disease, Coronavirus Infection, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents
[+]

Glycyrrhizin may act as a promising therapeutic avenue for the treatment of inflammatory pain.May 11, 2018

Pubmed Data : Exp Cell Res. 2018 May 12. Epub 2018 May 12. PMID: 29763588
Article Published Date : May 11, 2018
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Brain Inflammation , Inflammation
Pharmacological Actions : Analgesics
[+]

Glycyrrhizin may be used as an effective therapeutic agent against osteoporosis and bone resorption.May 01, 2018

Pubmed Data : Calcif Tissue Int. 2018 May 2. Epub 2018 May 2. PMID: 29721581
Article Published Date : May 01, 2018
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Osteoporosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Nrf2 activation, Osteoprotective
[+]

Glycyrrhizin may become a novel cytokine for the therapy of intervertebral disc degeneration in the future.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2019 ;11(8):5105-5113. Epub 2019 Aug 15. PMID: 31497226
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

Glycyrrhizin may reduce the severity of an infection with COVID-19 at the two stages of the COVID-19 induced disease process.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2020;11:1239. Epub 2020 May 28. PMID: 32574273
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Coronavirus Infection
Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents
[+]

Glycyrrhizin might be used for complementary and alternative therapeutics of allergic rhinitis.Feb 12, 2018

Pubmed Data : Chem Biol Interact. 2018 Feb 13 ;285:21-26. Epub 2018 Feb 13. PMID: 29452068
Article Published Date : Feb 12, 2018
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Allergic Rhinitis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Glycyrrhizin prevents SARS-CoV-2 S1 and Orf3a induced high mobility group box 1 (HMGB1) release and inhibits viral replication.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cytokine. 2021 06 ;142:155496. Epub 2021 Mar 12. PMID: 33773396
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Coronavirus Infection
Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation
[+]

Glycyrrhizin suppresses the growth of human NSCLC cell line HCC827. Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2018 ;2018:6916797. Epub 2018 Jan 15. PMID: 29568761
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

Glycyrrhizin, a potential drug for autoimmune encephalomyelitis by inhibiting high-mobility group box 1.Nov 30, 2018

Pubmed Data : DNA Cell Biol. 2018 Dec ;37(12):941-946. Epub 2018 Oct 16. PMID: 30325653
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Encephalomyelitis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Glycyrrhizin.inhibits herpex simplex virus infection. Jan 01, 2012

Pubmed Data : Cell Biochem Biophys. 2012 Jan ;62(1):137-40. PMID: 21874590
Article Published Date : Jan 01, 2012
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Herpex Simplex Virus
Pharmacological Actions : Antiviral Agents
[+]

Glycyrrhizin: An old weapon against a novel coronavirus.Sep 08, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytother Res. 2020 Sep 9. Epub 2020 Sep 9. PMID: 32902005
Article Published Date : Sep 08, 2020
Study Type : Review
Additional Links
Substances : Glycyrrhizin
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Identification of potential natural inhibitors of the receptor-binding domain of the SARS-CoV-2 spike protein using a computational docking approach.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Qatar Med J. 2021 ;2021(1):12. Epub 2021 Mar 12. PMID: 34604010
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Glycyrrhizin, Theaflavins
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Mechanism of action of glycyrrhizin against Plasmodium falciparum.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mem Inst Oswaldo Cruz. 2021 ;116:e210084. Epub 2021 Aug 20. PMID: 34431854
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Malaria
Pharmacological Actions : Antimalarials
Additional Keywords : Plant Extracts
[+]

This review shows the enhancing effects of bioenhancers of drugs, nutrients and vitamins in animals and humans.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ScientificWorldJournal. 2012 ;2012:637953. Epub 2012 Sep 17. PMID: 23028251
Article Published Date : Dec 31, 2011
Study Type : Review
Additional Links
Substances : Allicin, Aloe Vera, Capsaicin, Citrus naringin, Curcumin, Genistein, Glycyrrhizin, Piperine, Quercetin
Additional Keywords : Drug Interaction, Natural Substance/Drug Synergy, Supplementation
[+]

This review summarizes all the potential interventions for COVID‐19 infection according to previous treatments of SARS and MERS.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Virol. 2020 05 ;92(5):479-490. Epub 2020 Mar 3. PMID: 32052466
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : Alpha-Lipoic Acid, Emodin, Flavonoids, Glycyrrhizin, Iron , Omega-3 Fatty Acids, Riboflavin (Vitamin B-2), Selenium, Vitamin A, Vitamin C, Vitamin D, Vitamin E, Zinc
Diseases : Coronavirus Disease, Coronavirus Infection
Pharmacological Actions : Antiviral Agents, Immunomodulatory, Immunostimulatory
Additional Keywords : Risk Reduction

Copyright: limpido / 123RF Stock Photo

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Licorice has a rich and ancient history of use as a medicine, being rooted in Indian, Chinese, Greek and Egyptian traditions, alike. Technically a legume, related to beans and peas, its sweetness results from the presence of glycyrrhizin, a compound 30-50 times sweeter than sugar. This compound is what gave licorice its name, which derives from the Greek word γλυκύρριζα (glukurrhiza), meaning "sweet” (gluku) "root" (rrhiza)

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