Glycyrrhizin

Name	AC	CK
Psoriasis	3	24
Coronavirus Infection	12	21
Inflammation	10	17
Oxidative Stress	7	15
Coronavirus Disease (Covid-19)	4	13
Stroke: Ischemic	2	11
Acute Respiratory Distress Syndrome	1	10
Addison's Disease	1	10
Hepatitis: Autoimmune	1	10
Oral Lichen Planus	1	10
Rosacea	1	10
Vitiligo	1	10
Wound Healing	5	10
Diabetic Complications	5	9
Liver Damage: Drug-Induced	4	9
Brain Inflammation	5	8
Colorectal Cancer	3	8
Diabetes Mellitus: Type 2	2	8
Fatty Liver	3	7
Lipopolysaccharide-Induced Toxicity	4	7
Nonalcoholic fatty liver disease (NAFLD)	4	7
Sepsis	3	6
Colitis	2	5
Liver Cancer	5	5
Acetaminophen (Tylenol) Toxicity	2	4
Atopic Dermatitis	2	4
Chemotherapy-Induced Toxicity: Cisplatin	3	4
Epilepsy	2	4
Liver Damage	2	4
Lung Damage	2	4
Lung Injury: Acute	2	4
Obesity	2	4
Chemotherapy-Induced Toxicity: Paclitaxel	1	3
Encephalomyelitis	2	3
Gastric Ulcer	1	3
Hepatitis C	2	3
Hepatitis: Lectin-Induced (concanavalin)	2	3
Insulin Resistance	2	3
Liver Injury: Ischemia/reperfusion	2	3
Middle Cerebral Artery Occlusion (MCAO)	1	3
Alzheimer's Disease	2	2
Animal Diseases: Infectious	1	2
Anxiety	1	2
Asthma	1	2
Brain Ischemia	1	2
Cancers: All	2	2
Cancers: Drug Resistant	2	2
Cardiovascular Diseases	1	2
Cerebral Ischemia	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Cognitive Decline/Dysfunction	1	2
Diabetic Nephropathy	1	2
Dysbiosis	1	2
Dyslipidemias	1	2
H5N1 Infection	2	2
High Fat Diet	1	2
Influenza A	2	2
Iron Poisoning	1	2
Kidney Damage: Drug-Induced	1	2
Liver Fibrosis	1	2
Mastitis	1	2
Melanoma	2	2
Memory Disorders	1	2
Metabolic Diseases	1	2
Multiple Sclerosis	1	2
Pancreatitis	1	2
Peripheral Neuropathies	1	2
Premature Birth	1	2
Puberty: Precocious	1	2
Pulmonary Fibrosis	2	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Respiratory Distress Syndrome	1	2
Salmonella Infections	1	2
Seizures	1	2
Tardive Dyskinesia	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Ulcerative Colitis	1	2
Venous Thrombosis	1	2
Aging	1	1
Allergic Rhinitis	1	1
Alopecia	1	1
Breast Cancer	1	1
Carcinoma: Non-Small-Cell Lung	1	1
DNA damage	1	1
Degenerative Disk Disease	1	1
Gastric Cancer	1	1
Hepatitis	1	1
Herpex Simplex Virus	1	1
Liver Cirrhosis	1	1
Malaria	1	1
Methicillin-resistant Staphylococcus aureus	1	1
Necrotising enterocolitis	1	1
Neurodegenerative Diseases	1	1
Osteoporosis	1	1
Ovarian Cancer	1	1
Parkinson's Disease	1	1
Periodontal Diseases	1	1
Periodontitis	1	1
Peripheral Nerve Damage	1	1
Photooxidative Stress	1	1
Prostate Cancer	1	1
Pseudomonas aeruginosa	1	1
Pseudorabies Herpesvirus	1	1
Silicosis	1	1
Skin Diseases: Photo-Aging	1	1
Traumatic Brain Injury	1	1

Name	AC	CK
Anti-Inflammatory Agents	51	92
Hepatoprotective	19	53
Neuroprotective Agents	19	42
Antiviral Agents	18	36
Interleukin-6 Downregulation	11	28
Tumor Necrosis Factor (TNF) Alpha Inhibitor	11	28
Antioxidants	14	24
Immunomodulatory	7	17
Interleukin-1 beta downregulation	12	17
NF-kappaB Inhibitor	11	16
Anti-Apoptotic	8	15
Nrf2 activation	6	11
Angiotensin-Converting Enzyme Inhibitors	1	10
CYP3A enzyme induction	1	10
Chemoprotective Agents	4	10
Antiproliferative	6	9
Chemopreventive	4	9
Cytoprotective	2	9
Apoptotic	6	8
Cardioprotective	4	8
Gastrointestinal Agents	4	8
Anti-Bacterial Agents	4	6
Heme oxygenase-1 up-regulation	3	6
Interferon Gamma Reducer	3	6
Interleukin-17 downregulation	3	6
Anti-Fibrotic	3	5
Hypolipidemic	2	4
Interleukin-18 down-regulation	2	4
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	4
MicroRNA modulator	2	4
Angiogenesis Inhibitors	2	3
Anti-Ulcer Agents	1	3
Antineoplastic Agents	3	3
Chemotherapeutic	3	3
Cyclin D1 Down-Regulation	1	3
Gastroprotective	1	3
Hypoglycemic Agents	2	3
Interleukin-10 upregulation	2	3
Anti-Anxiety Agents	1	2
Autophagy Inhibitors	1	2
Autophagy Up-regulation	1	2
Chemosensitizer	2	2
Insulin Sensitizers	1	2
Interleukin-12 downregulation	1	2
Interleukin-23 Downregulation	1	2
Radioprotective	1	2
Renoprotective	1	2
Analgesics	1	1
Anti-metastatic	1	1
Antimalarials	1	1
Bcl-2 protein down-regulation	1	1
Cell cycle arrest	1	1
Cyclooxygenase 2 Inhibitors	1	1
Immunostimulatory	1	1
Interleukin-8 downregulation	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Multidrug Resistance Gene Modulators	1	1
Osteoprotective	1	1
Postaglandin PGE2 downregulation	1	1
Superoxide Dismutase Up-regulation	1	1
Transforming growth factor beta (TGF-β) inhibitor	1	1
Vascular Endothelial Growth Factor Inhibitors	1	1

Additional Keywords : Cytokine Storm

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[Extraction of miRNA from Glycyrrhiza uralensis Decoction and Its Effect on Immune Cells].Jun 30, 2015

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Pubmed Data : Zhong Yao Cai. 2015 Jul ;38(7):1449-53. PMID: 26946842

Article Published Date : Jun 30, 2015

Study Type : Human Study

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Substances : Glycyrrhizin

Additional Keywords : MicroRNA, Plant Extracts

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Glycyrrhizin ameliorates vascular endothelial cell senescence by inhibiting HMGB1 in HFD/STZ-induced diabetes.Sep 14, 2022

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Pubmed Data : Eur J Pharmacol. 2022 Sep 15 ;931:175196. Epub 2022 Aug 18. PMID: 35987259

Article Published Date : Sep 14, 2022

Study Type : Animal Study, Human In Vitro

Additional Links

Substances : Glycyrrhizin

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Cytoprotective

Additional Keywords : Senescence-associated Secretory Phenotype

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Bioactive glycyrrhizic acid-astragalus polysaccharide hydrogel facilitates gastric ulcer healing.Aug 14, 2025

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Pubmed Data : Carbohydr Polym. 2025 Aug 15 ;362:123685. Epub 2025 Apr 29. PMID: 40409809

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Pubmed Data : J Ethnopharmacol. 2025 Feb 11 ;341:119337. Epub 2025 Jan 7. PMID: 39788166

Article Published Date : Feb 10, 2025

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Glycyrrhizin

Diseases : Colitis, Colorectal Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Glycyrrhizin ameliorates colorectal cancer progression.Oct 22, 2024

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Pubmed Data : Nutrients. 2022 Oct 8 ;14(19). Epub 2022 Oct 8. PMID: 36235833

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Pubmed Data : Neurochem Res. 2025 Jan 9 ;50(1):75. Epub 2025 Jan 9. PMID: 39786594

Article Published Date : Jan 08, 2025

Study Type : Animal Study

Additional Links

Substances : Glycyrrhizin

Diseases : Tardive Dyskinesia

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation

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Glycyrrhizic acid hydrogel microparticles encapsulated with mesenchymal stem cell exosomes for wound healing.Dec 31, 2023

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Pubmed Data : Research (Wash D C). 2024 ;7:0496. Epub 2024 Oct 14. PMID: 39403257

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Pubmed Data : J Ethnopharmacol. 2025 Jun 12 ;349:119895. Epub 2025 Apr 28. PMID: 40306499

Article Published Date : Jun 11, 2025

Study Type : Animal Study

Additional Links

Substances : Glycyrrhizin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

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Glycyrrhizic acid promotes sciatic nerves recovery in type 1 diabetic rats and protects Schwann cells from high glucose-induced cytotoxicity.May 14, 2022

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Pubmed Data : Biomed Pharmacother. 2019 Feb ;110:692-699. Epub 2018 Dec 12. PMID: 30553196

Article Published Date : Jan 31, 2019

Study Type : Animal Study

Additional Links

Substances : Glycyrrhizin

Diseases : Hepatitis: Lectin-Induced (concanavalin)

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interferon Gamma Reducer, Interleukin-17 downregulation, Interleukin-6 Downregulation

Problem Substances : Concanavalin A

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Glycyrrhizin alleviates non-alcoholic steatohepatitis.Jun 28, 2018

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Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:8438528. Epub 2022 Apr 7. PMID: 35432719

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Glycyrrhizin

Diseases : Brain Inflammation , Brain Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

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Glycyrrhizin attenuates Salmonella typhimurium-induced tissue injury.Dec 31, 2020

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Pubmed Data : Indian J Pharmacol. 2015 Jan-Feb;47(1):39-44. PMID: 25821309

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Pubmed Data : PLoS One. 2011 ;6(5):e19705. Epub 2011 May 17. PMID: 21611183

Article Published Date : Jan 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Glycyrrhizin

Diseases : H5N1 Infection, Influenza A

Pharmacological Actions : Antioxidants, Antiviral Agents, Cell cycle arrest, NF-kappaB Inhibitor

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A review of natural products, their effects on SARS-CoV-2 and their utility as lead compounds in the discovery of drugs for the treatment of COVID-19.Dec 01, 2021

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Pubmed Data : Med Chem Res. 2021 Dec 2:1-12. Epub 2021 Dec 2. PMID: 34873386

Article Published Date : Dec 01, 2021

Study Type : Review

Additional Links

Substances : Baicalein, Flavonoids, Glycyrrhizin, Kaempferol, Polyphenols, Quercetin

Diseases : Coronavirus Infection

Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents

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Pubmed Data : Pathogens. 2020 Sep 18 ;9(9). Epub 2020 Sep 18. PMID: 32962036

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Pubmed Data : Front Oncol. 2019 ;9:1431. Epub 2020 Jan 9. PMID: 31998631

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Glycyrrhizin is a Sub of the following Topic

View the Evidence: 130 Abstracts with Glycyrrhizin Research

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Compound glycyrrhizin plus conventional therapy for psoriasis vulgaris.Dec 31, 2016

Administration of glycyrrhizin resulted in a modest induction of CYP3A that was clinically relevant according to the bioequivalence analysis.Jul 31, 2010

Compared with the hormone treatment, glycyrrhizic acid preparation might be a safe and effective treatment for autoimmune hepatitis.Jan 17, 2023

Efficacy of diammonium glycyrrhizinate in the treatment of rosacea with papules and pustules.Nov 30, 2022

Glycyrrhizin alleviates the toxicity of hydroxychloroquine in treating oral lichen planus.Nov 30, 2024

Glycyrrhizin and ultraviolet B light therapy improved active-stage generalized vitiligo.Jul 24, 2016

Glycyrrhizin prevents hemorrhagic transformation and improves neurological outcome in ischemic stroke with delayed thrombolysis.Dec 23, 2019

Liquorice and soy sauce has been reported a life-saving concoction in a patient with Addison's disease.Jun 30, 2007

Liquorice intake modulates ACE2 and HMGB1 levels in healthy individuals.Dec 31, 2021

Nebulized glycyrrhizin/enoxolone drug modulates IL-17A in COVID-19 patients.Dec 31, 2022

[Extraction of miRNA from Glycyrrhiza uralensis Decoction and Its Effect on Immune Cells].Jun 30, 2015

Glycyrrhizin ameliorates vascular endothelial cell senescence by inhibiting HMGB1 in HFD/STZ-induced diabetes.Sep 14, 2022

Bioactive glycyrrhizic acid-astragalus polysaccharide hydrogel facilitates gastric ulcer healing.Aug 14, 2025

Glycyrrhizic acid alleviates gefitinib-induced liver injury.May 31, 2025

Glycyrrhizic acid inhibits hippocampal neuron apoptosis.Oct 07, 2024

Glycyrrhizic acid mitigates hepatocyte steatosis and inflammation.Sep 04, 2025

Glycyrrhizic acid prevents paclitaxel-induced neuropathy.Apr 24, 2023

Glycyrrhizic acid reduces neutrophil extracellular trap formation to ameliorate colitis-associated colorectal cancer.Feb 10, 2025

Glycyrrhizin ameliorates colorectal cancer progression.Oct 22, 2024

Glycyrrhizin mitigates acute lung injury by inhibiting the NLRP3 inflammasome.Feb 28, 2023

"A glycyrrhizin-containing preparation reduces hepatic steatosis induced by hepatitis C virus protein and iron in mice."Apr 01, 2011

Ameliorative effect of glycyrrhizic acid on diosbulbin B-induced liver injury.Dec 31, 2024

Cardioprotective action of glycyrrhizin on diabetic rats with myocardial remodeling.Dec 31, 2020

Cardioprotective effect of glycyrrhizin on myocardial remodelling in diabetes.Apr 12, 2021

Effect of glycyrrhizin administration followed by symptom-based antimicrobial selection therapy on antimicrobial use in clinical mastitis.Sep 11, 2022

Effect of loaded glycyrrhizic acid on PLGA nano-particle on treatment of allergic asthma.Feb 05, 2022

Ethanol extract of licorice alleviates HFD-induced liver fat accumulation.Oct 07, 2022

Glycyrrhetinic acid triggers a protective autophagy by inhibiting the JAK2/STAT3 pathway in cerebral ischemia/reperfusion injury.Aug 29, 2024

Glycyrrhizic acid alleviates concanavalin A-induced acute liver injury.Sep 30, 2024

Glycyrrhizic acid ameliorates hepatic fibrosis by inhibiting oxidative stress.Sep 30, 2024

Glycyrrhizic acid ameliorates sepsis-induced acute lung injury.Apr 30, 2025

Glycyrrhizic acid and glycyrrhetinic acid loaded cyclodextrin MOFs with enhanced antibacterial and anti-inflammatory effects.Dec 31, 2024

Glycyrrhizic acid and patchouli alcohol in Huoxiang Zhengqi attenuate intestinal inflammation and barrier injury.Feb 09, 2025

Glycyrrhizic acid can be a therapeutic agent for tardive dyskinesia and other neurological disorders.Jan 08, 2025

Glycyrrhizic acid hydrogel microparticles encapsulated with mesenchymal stem cell exosomes for wound healing.Dec 31, 2023

Glycyrrhizic acid improves tacrolimus-induced renal injury by regulating autophagy.Jan 31, 2023

Glycyrrhizic acid inhibits core fucosylation modification modulated EMT and attenuates bleomycin-induced pulmonary fibrosis.Dec 31, 2021

Glycyrrhizic acid promotes liver regeneration through activating β-catenin in acetaminophen-induced liver injury.Jun 11, 2025

Glycyrrhizic acid promotes sciatic nerves recovery in type 1 diabetic rats and protects Schwann cells from high glucose-induced cytotoxicity.May 14, 2022

Glycyrrhizic acid protects against non-alcoholic fatty liver disease in mice due to regulation of genes involved in lipid, glucose homeostasis and insulin sensitivity.Jul 05, 2017

Glycyrrhizic acid protects against temporal lobe epilepsy.Jan 16, 2023

Glycyrrhizic acid protects experimental sepsis rats against acute lung injury and inflammation.Dec 31, 2021

Glycyrrhizic acid suppresses atopic dermatitis-like symptoms by regulating the immune balance.Sep 12, 2022

Glycyrrhizic acid treatment ameliorates anxiety-like behaviour.Jun 27, 2024

Glycyrrhizin alleviates BoAHV-1-induced lung injury.Jul 31, 2024

Glycyrrhizin alleviates Con A-induced hepatitis.Jan 31, 2019

Glycyrrhizin alleviates non-alcoholic steatohepatitis.Jun 28, 2018

Glycyrrhizin alleviates sepsis-induced acute respiratory distress syndrome.Jun 30, 2022

Glycyrrhizin ameliorates atopic dermatitis-like symptoms.Apr 23, 2018

Glycyrrhizin ameliorates cardiac injury in rats with severe acute pancreatitis.Jun 30, 2024

Glycyrrhizin ameliorates the progression of alcoholic fatty liver.Mar 07, 2024

Glycyrrhizin attenuates carcinogenesis by inhibiting the inflammatory response in a murine model of colorectal cancer.Mar 04, 2021

Glycyrrhizin attenuates hypoxic-ischemic brain damage by inhibiting ferroptosis and neuroinflammation.Dec 31, 2021

Glycyrrhizin attenuates Salmonella typhimurium-induced tissue injury.Dec 31, 2020

Glycyrrhizin attenuates white matter injury by inhibiting neuroinflammation. Apr 30, 2025

Glycyrrhizin could be a potential candidate for the prevention of doxorubicin induced cardiotoxicity.Dec 31, 2019

Glycyrrhizin has been proven to be a strong antioxidant as well as antiapoptotic and cytoprotective against CIS testicular damage.Dec 31, 2024

Glycyrrhizin improves inflammation and apoptosis via suppressing HMGB1 and PI3K/mTOR pathway in lipopolysaccharide-induced acute liver injury.May 31, 2020

Glycyrrhizin improves the pathogenesis of psoriasis.May 26, 2021

Glycyrrhizin mitigates radiation‐induced acute lung injury.Dec 31, 2019

Glycyrrhizin modulates chronic seizures-induced memory dysfunction.Aug 30, 2021

Glycyrrhizin possesses therapeutic potential against hepatocellular damage in metabolic syndrome. Oct 31, 2015

Glycyrrhizin protects mice against experimental autoimmune encephalomyelitis.Dec 31, 2017

Glycyrrhizin regulates the HMGB1/P38MAPK signalling pathway in status epilepticus.Jan 31, 2023

Glycyrrhizin-based hydrogels accelerate wound healing of normoglycemic and diabetic mouse skin.Dec 20, 2022

N-acetylcysteine and glycyrrhizin combination: Benefit outcome in a murine model of acetaminophen-induced liver failure.Sep 26, 2020

Natural sweetener glycyrrhizin protects against precocious puberty by modulating the gut microbiome.Jul 31, 2024

Pre-treatment with glycyrrhizin inhibited venous thrombosis.Dec 31, 2015

Pulmonary delivery of curcumin-loaded glycyrrhizic acid nanoparticles for anti-inflammatory therapy.Oct 19, 2022

Spirulina and glycyrrhizin has a potential role in reversing cognitive dysfunctions associated with aging and obesity.Dec 31, 2014

The protective effect of glycyrrhizin on hepatic ischemia-reperfusion injury in rats and possible related signal pathway.Aug 31, 2020

The therapeutic effect of glycyrrhizic acid compound ointment on imiquimod-induced psoriasis-like disease.Dec 31, 2022

Glycyrrhizin

View the Evidence:
130 Abstracts with Glycyrrhizin Research