Grape Seed Extract

Name	AC	CK
Hypertension	9	85
Oxidative Stress	27	80
Obesity	16	55
Cardiovascular Diseases	7	53
Inflammation	8	41
Atherosclerosis	4	32
C-Reactive Protein	3	32
Insulin Resistance	4	32
Lung Cancer	4	22
Blood Diseases	1	20
Prehypertension	2	20
Diabetes Mellitus: Type 2	6	18
Hyperlipidemia	3	14
Periodontitis	3	14
Aging Skin	3	12
Chemically-Induced Liver Damage	6	12
Diabetic Retinopathy	2	12
High Fat Diet	6	12
Triglycerides: Elevated	2	12
Radiation	2	11
Wound Healing	2	11
Chloasma	1	10
Cognitive Decline/Dysfunction	1	10
Coronary Bypass Surgery	1	10
DNA damage	6	10
Endothelial Dysfunction	1	10
Hypercholesterolemia	1	10
Leg Edema	1	10
Menopausal Syndrome	1	10
Metabolic Syndrome X	1	10
Muscle Damage: Exercise-Induced	1	10
Overweight	1	10
Postmenopausal Disorders	1	10
Sclerosis: Systemic	1	10
Sitting Sickness	1	10
Streptococcus Infections	1	10
Chemotherapy-Induced Toxicity: Doxorubicin	5	9
Prostate Cancer	7	9
Diabetes Mellitus: Type 1	4	8
Diabetic Nephropathy	4	8
Kidney Damage	4	8
Chemotherapy-Induced Toxicity: Cisplatin	4	7
Squamous cell carcinoma	3	7
Aging: Brain	3	6
Breast Cancer	5	6
Colorectal Cancer	4	6
Hyperglycemia	3	6
Kidney Damage: Chemically-Induced	3	6
Lead Poisoning	3	6
Neurodegenerative Diseases	3	6
Acetaminophen (Tylenol) Toxicity	2	4
Advanced Glycation End products (AGE)	2	4
Alzheimer's Disease	2	4
Arsenic Poisoning	2	4
Bisphenol Toxicity	2	4
Brain Ischemia	2	4
Cataract	2	4
Colitis	2	4
Colon Cancer	3	4
Diabetes: Cardiovascular Illness	2	4
Diabetes: Cognitive Dysfunction	2	4
Diabetes: Oxidative Stress	2	4
Diabetic Complications	2	4
Fluoride Toxicity	2	4
Gout	2	4
Hypertension: Pulmonary	2	4
Iron Overload	2	4
Kidney Damage: Drug-Induced	2	4
Liver Cancer	2	4
Parkinson's Disease	2	4
Testicular Injury: Chemical/Metal Induced	2	4
Aging	2	3
Dyslipidemias	2	3
Lipid Peroxidation	2	3
Pancreatic Cancer	2	3
Periodontal Diseases	2	3
Ultraviolet Radiation Induced Damage	2	3
Air Pollution Linked Toxicity	1	2
Alcohol Toxicity	1	2
Allodynia	1	2
Androgenic Alopecia	2	2
Appetite Disorders	1	2
Arteriosclerosis	1	2
Bladder Cancer	2	2
Blood Sugar Problems	1	2
Bone Diseases	1	2
Brain Inflammation	1	2
Cadmium Poisoning	1	2
Cancers: All	2	2
Cancers: Canine	1	2
Candida Albicans	1	2
Candidiasis: Vulvovaginal	1	2
Cardiomyopathy	1	2
Cardiotoxicity: Chemotherapy-Induced	1	2
Cerebral Hypoperfusion	1	2
Cerebral Ischemia	1	2
Chemical Exposure: Nitrobenzene	1	2
Chemotherapy Induced Myelotoxicity	1	2
Chemotherapy-Induced Toxicity: Arsenic Trioxide	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Chemotherapy-Induced Toxicity: Tamoxifen	1	2
Circadian Dysregulation	1	2
Deep Vein Thrombosis	1	2
Depression	1	2
Diabetic Neuropathy	1	2
Drug-Induced Toxicity	1	2
Dysbiosis	1	2
Ehrlich carcinoma	1	2
Endotoxemia	1	2
Excitotoxicity	1	2
Fatigue: Excercise-Induced	1	2
Fructose-Induced Toxicity	1	2
Gastrointestinal Complaints	1	2
Hyperinsulinism	1	2
Hyperthyroidism	1	2
Hyperuricemia	1	2
Inflammatory Bowel Diseases	1	2
Insulin Disorders	1	2
Intestinal Cancer	1	2
Intestinal Polyps	1	2
Irritable Bowel Syndrome	1	2
Ischemia	1	2
Kidney Diseases	1	2
Kidney Failure	1	2
Kidney Fibrosis	1	2
Lipopolysaccharide-Induced Toxicity	1	2
Liver Damage	1	2
Liver Damage: Drug-Induced	1	2
Liver Fibrosis	1	2
Lung Injury: Acute	1	2
MRSA	1	2
Memory Disorders	1	2
Memory Disorders: Sleep Deprivation Induced	1	2
Morphine Tolerance/Dependence	1	2
Muscle Atrophy	1	2
Myocardial Infarction	1	2
Neuropathic Pain	1	2
Osteoarthritis: Knee	1	2
Pesticide-Induced Toxicity: Organophosphates	1	2
Polycystic Ovary Syndrome	1	2
Pulmonary Fibrosis	1	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Respiratory Syncytial Virus Infections	2	2
Sperm Count: Low	1	2
Steroid-Induced Toxicity	1	2
Stroke	1	2
Stroke: Attenuation/Recovery	1	2
Stroke: Ischemic	1	2
Testicular Injury: Cadmium-Induced	1	2
Thrombosis	1	2
Ulcerative Colitis	1	2
Varicocele	1	2
Acute Myeloid Leukemia	1	1
Alopecia: Androgenic	1	1
Cancer Metastasis	1	1
Cancers: Drug Resistant	1	1
Candida Infection	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Cholesterol: Oxidation	1	1
Dental Caries	1	1
Enterococcus Infections	1	1
Esophageal Cancer	1	1
Glioma	1	1
HIV Infections	1	1
Hair Loss	1	1
Head and Neck Cancer	1	1
Helicobacter Pylori Infection	1	1
Hepatitis A	1	1
Hepatitis C	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Hypoxia	1	1
Leukemia	1	1
Male Pattern Baldness	1	1
Melanoma: Metastatic	1	1
Melasma	1	1
Mitochondrial Dysfunction	1	1
Mucositis	1	1
Myocardial Ischemia	1	1
Nicotine/Tobacco Toxicity	1	1
Oral Cancer	1	1
Osteoarthritis	1	1
Ovarian Cancer	1	1
Peptic Ulcer	1	1
Pulmonary Cancer	1	1
Sepsis	1	1
Skin Cancer: Squamous Cell	1	1
Staphylococcus aureus infection	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Tongue Cancer	1	1
Water Contamination	1	1

Name	AC	CK
Antioxidants	77	214
Anti-Inflammatory Agents	25	88
Antihypertensive Agents	8	74
Cardioprotective	11	53
Neuroprotective Agents	20	48
Apoptotic	23	39
Antiproliferative	21	35
Chemopreventive	9	34
Anti-Apoptotic	19	33
Anti-atherogenic	3	30
Hypotensive	2	30
Renoprotective	15	30
Hepatoprotective	10	20
Hypolipidemic	6	19
Malondialdehyde Down-regulation	4	16
Nrf2 activation	8	16
Anti-Bacterial Agents	5	15
Chemoprotective Agents	7	13
Interleukin-6 Downregulation	7	13
Insulin Sensitizers	2	12
Radioprotective	3	12
Tumor Necrosis Factor (TNF) Alpha Inhibitor	6	12
Antimicrobial	2	11
Antineoplastic Agents	6	11
Cytoprotective	5	10
Gastrointestinal Agents	5	10
Glutathione Upregulation	1	10
NF-kappaB Inhibitor	6	10
Nitric Oxide Enhancer	1	10
Vasoprotective	1	10
Cell cycle arrest	5	8
Genoprotective	5	8
Cyclooxygenase 2 Inhibitors	4	7
Interleukin-1 beta downregulation	4	7
Superoxide Dismutase Up-regulation	4	7
Heme oxygenase-1 up-regulation	3	6
Hypoglycemic Agents	3	5
MicroRNA modulator	3	5
Adiponectin upregulation	2	4
Anti-Fibrotic	2	4
Anticarcinogenic Agents	2	4
Gastroprotective	2	4
Heme oxygenase-1 inducer	2	4
Interleukin-10 downregulation	2	4
Osteoprotective	2	4
Antifungal Agents	2	3
Antiviral Agents	3	3
Aromatase Inhibitors	2	3
Bcl-2 protein down-regulation	2	3
Chemotherapeutic	3	3
Survivin Down-Regulation	2	3
Adiponectin Down-Regulation	1	2
Alpha-glucosidase inhibitor	1	2
Anti-Angiogenic	1	2
Anti-thrombotic	1	2
Anticholesteremic Agents	1	2
Antidepressive Agents	1	2
Antinoceceptive	1	2
Appetite Stimulants	1	2
Brain-derived neurotrophic factor modulator	1	2
Catalase Up-Regulation	1	2
DNA Repair Up-regulation	1	2
Heat Shock Protein Down-Regulation	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	2
Insulin-Like Growth Factor Inhibition/Downregulation	1	2
Matrix metalloproteinase-8 (MMP-8) inhibitor	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	2
Multidrug Resistance Gene Modulators	2	2
Neurorestorative	1	2
Nitric Oxide Inhibitor	1	2
Pancreato Protective Agents	1	2
Thermogenic	1	2
Wnt/β-catenin signaling pathway modulation	1	2
Anti-Adipogenic	1	1
Anti-HIV Agents	1	1
Anti-Ulcer Agents	1	1
Anti-metastatic	1	1
Autophagy Up-regulation	1	1
Caspase-3 Inhibition	1	1
Chemosensitizer	1	1
Cyclin D1 Down-Regulation	1	1
Epidermal growth factor receptor (EGFR) inhibitor	1	1
Interleukin-8 downregulation	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Photoprotective	1	1
Tumor Suppressor Protein p53 Upregulation	1	1

[+]

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Front Nutr. 2023 ;10:1139880. Epub 2023 Jun 7. PMID: 37351191

Article Published Date : Dec 31, 2022

Study Type : Human Study

Additional Links

Substances : Bilberry, Grape Seed Extract

Diseases : Diabetes Mellitus: Type 2, Hypertension

Pharmacological Actions : Antihypertensive Agents

[+]

A grape seed extract reduces the inflammatory response and oxidative stress in patients with systemic sclerosis.Aug 01, 2002

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Pubmed Data : Free Radic Res. 2002 Aug;36(8):819-25. PMID: 12420739

Pubmed Data : J Biol Regul Homeost Agents. 2021 ;35(2 Suppl. 1):89-96. PMID: 34281305

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : Grape Seed Extract

Diseases : Periodontitis

[+]

Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome.Nov 30, 2009

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Pubmed Data : Metabolism. 2009 Dec ;58(12):1743-6. Epub 2009 Jul 15. PMID: 19608210

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Pubmed Data : Phytother Res. 2019 Nov 11. Epub 2019 Nov 11. PMID: 31713941

Article Published Date : Nov 10, 2019

Study Type : Human Study

Additional Links

Substances : Grape Seed Extract

Diseases : Inflammation, Obesity, Overweight

Therapeutic Actions : Dietary Modification: Low Calorie Diet

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Anti-Obesity Agents

[+]

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Pubmed Data : J Med Food. 2018 May ;21(5):445-453. Epub 2018 Apr 23. PMID: 29683391

Article Published Date : Apr 30, 2018

Study Type : Human Study

Additional Links

Substances : Grape Seed Extract

Diseases : Prehypertension

Therapeutic Actions : Exercise

Pharmacological Actions : Antihypertensive Agents

[+]

Grape seed extract showed complete repair of wounds averagely on day 8 for the treatment group and on day 14 for the placebo group.Apr 30, 2015

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Grape seed proanthocyanidin extract had beneficial effects on the progression of carotid atherosclerotic plaques.Jun 30, 2015

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Pubmed Data : Mol Nutr Food Res. 2008 Aug 20; PMID: 18720348

Article Published Date : Aug 01, 2008

Study Type : Human Study

Additional Links

Substances : Grape Seed Extract

Diseases : Triglycerides: Elevated

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GSE and Vitamin C had antioxidative effects and reduced deleterious effects of coronary artery bypass grafting surgery.Dec 31, 2016

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Pubmed Data : Ann Card Anaesth. 2017 Jan-Mar;20(1):45-51. PMID: 28074795

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Pubmed Data : Pharm Biol. 2022 Dec ;60(1):347-358. PMID: 35171066

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Pubmed Data : Sao Paulo Med J. 2016 May 13 ;134(3):234-9. PMID: 27191247

Article Published Date : May 12, 2016

Study Type : Human Study

Additional Links

Substances : Grape Seed Extract

Diseases : Atherosclerosis, Hyperlipidemia

Pharmacological Actions : Anti-atherogenic, Antioxidants

Additional Keywords : Phytotherapy

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The aqueous extracts of the chosen herbal plants showed an acceptable antibacterial efficacy against oral streptococci.Oct 30, 2017

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Pubmed Data : J Clin Pediatr Dent. 2017 Oct 31. Epub 2017 Oct 31. PMID: 29087796

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Pubmed Data : Chin J Integr Med. 2023 May ;29(5):394-404. Epub 2023 Jan 6. PMID: 36607588

Article Published Date : Apr 30, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Grape Seed Extract

Diseases : Multiple Sclerosis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Pubmed Data : Environ Pollut. 2018 Jun ;237:377-387. Epub 2018 Mar 15. PMID: 29502000

Grape seed and skin extract acts at multiple levels to protect dopamine neurons from degeneration in a model of Parkinson's disease.May 24, 2019

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Pubmed Data : Nutr Neurosci. 2019 May 25:1-15. Epub 2019 May 25. PMID: 31131731

Pubmed Data : Andrologia. 2018 Jun ;50(5):e13002. Epub 2018 Mar 12. PMID: 29527700

Article Published Date : May 31, 2018

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants

Problem Substances : Dexamethasone

[+]

Grape seed extract attenuates silica-induced pulmonary fibrosis in rats. Aug 01, 2009

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Pubmed Data : Reproduction. 2009 Aug;138(2):279-87. Epub 2009 Jun 3. PMID: 18547852

Article Published Date : Aug 01, 2009

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Pulmonary Fibrosis

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Grape seed extract can be used as an auxiliary treatment for muscle loss associated with chronic inflammation and frailty.May 19, 2014

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Pubmed Data : J Med Food. 2010 Aug;13(4):917-25. PMID: 20553142

Article Published Date : Aug 01, 2010

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Cardiotoxicity: Chemotherapy-Induced, Chemotherapy-Induced Toxicity: Doxorubicin, DNA damage

Pharmacological Actions : Cardioprotective, Genoprotective

Additional Keywords : Drug: Doxorubicin

[+]

Grape seed extract has a rejuvenating effect in the central nervous system of aged rats. Aug 05, 2005

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Pubmed Data : Neurosci Lett. 2005 Aug 5;383(3):295-300. PMID: 15955424

Article Published Date : Aug 05, 2005

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Pubmed Data : Toxics. 2017 Apr 11 ;5(2). Epub 2017 Apr 11. PMID: 29051443

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Pubmed Data : Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6194-202. PMID: 17062697

Article Published Date : Oct 15, 2006

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Colorectal Cancer

Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemopreventive

Additional Keywords : Antineoplastic Agents, Antiproliferative, Plant Extracts

[+]

Grape seed extract may be beneficial as a complementary migraine therapeutic.Dec 31, 2021

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Pubmed Data : Toxicol Mech Methods. 2022 Jul 27:1-10. Epub 2022 Jul 27. PMID: 35850572

Article Published Date : Jul 26, 2022

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Grape seed extract protected against cadmium-induced testicular toxicity.Jan 12, 2020

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Pubmed Data : J Med Life. 2020 Oct-Dec;13(4):580-586. PMID: 33456610

Article Published Date : Sep 30, 2020

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Atherosclerosis, C-Reactive Protein, Periodontitis

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation

[+]

Grape seed extract supplementation prevents high-fructose diet-induced insulin resistance in rats by improving insulin and adiponectin signalling pathways.May 31, 2011

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Pubmed Data : Br J Nutr. 2011 May 31:1-9. Epub 2011 May 31. PMID: 21736810

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Pubmed Data : Front Nutr. 2021 ;8:786682. Epub 2022 Jan 28. PMID: 35155513

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract, Proanthocyanidins

Diseases : Gastrointestinal Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents

[+]

Grape seed proanthocyanidin ameliorates cardiac toxicity induced by boldenone undecylenate.Dec 31, 2017

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Pubmed Data : Free Radic Biol Med. 2021 10 ;174:144-156. Epub 2021 Aug 11. PMID: 34389464

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Pubmed Data : Food Chem Toxicol. 2023 Jul ;177:113795. Epub 2023 Apr 26. PMID: 37116776

Article Published Date : Jun 30, 2023

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Chronic Obstructive Pulmonary Disease, Emphysema: Pulmonary, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Grape seed proanthocyanidin extract can ameliorate abnormal spermatogenesis and testicular injury in varicocele rats.Dec 31, 2017

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Pubmed Data : Mol Med Rep. 2018 Jan ;17(1):1799-1806. Epub 2017 Nov 10. PMID: 29138814

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Oxidative Stress, Sperm Count: Low, Varicocele

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 inducer, Nrf2 activation, Superoxide Dismutase Up-regulation

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Grape seed proanthocyanidin extract supplementation alleviates DSS-induced colitis.Sep 22, 2020

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Pubmed Data : Food Funct. 2020 Sep 23 ;11(9):7817-7829. PMID: 32808642

Article Published Date : Sep 22, 2020

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Gastrointestinal Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Grape seed proanthocyanidin extract supplementation has anti-hypertrophic and hyperplasic activities in rats with established obesity.Apr 03, 2017

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Pubmed Data : Int J Obes (Lond). 2017 Apr 4. Epub 2017 Apr 4. PMID: 28373675

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Pubmed Data : Mol Nutr Food Res. 2015 May ;59(5):865-78. Epub 2015 Mar 23. PMID: 25677201

Article Published Date : Apr 30, 2015

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract, Melatonin, Proanthocyanidins

Diseases : Circadian Dysregulation

Additional Keywords : Chronobiotic, Circadian Clock Proteins, Plant Extracts

[+]

Grape seed proanthocyanidin inhibit advanced glycation end products in diabetic rats. Jun 01, 2009

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Pubmed Data : Biosci Biotechnol Biochem. 2009 Jun;73(6):1348-54. Epub 2009 Jun 7. PMID: 19502731

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Advanced Glycation End products (AGE), Diabetes: Cardiovascular Illness

Additional Keywords : Plant Extracts, Proanthocyanidins

[+]

Grape seed proanthocyanidin reverses pulmonary vascular remodeling in monocrotaline-induced pulmonary arterial hypertension.Apr 30, 2018

Pubmed Data : Food Funct. 2021 Sep 20 ;12(18):8467-8477. Epub 2021 Sep 20. PMID: 34296715

Article Published Date : Sep 19, 2021

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Obesity

Pharmacological Actions : Gastrointestinal Agents

Additional Keywords : Anti-Obesity Agents

[+]

Grape seed procyanidin B2 had hepatoprotective effects on CCl4-induced hepatic fibrosis in Sprague-Dawley rats and inhibited the inflammatory response and oxidative stress.Dec 31, 2014

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Pubmed Data : Altern Ther Health Med. 2015 ;21 Suppl 2:12-21. PMID: 26308756

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Chemically-Induced Liver Damage, Liver Fibrosis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

[+]

Grape seed procyanidin extract ameliorates lead-induced liver injury.Jan 31, 2018

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Pubmed Data : J Nutr Biochem. 2018 Feb ;52:115-123. Epub 2017 Oct 12. PMID: 29175668

Article Published Date : Jan 31, 2018

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective, MicroRNA modulator, Nrf2 activation

Additional Keywords : Procyanidins

Problem Substances : Lead

[+]

Grape seed procyanidin extract attenuate sodium fluoride-induced oxidative damage and apoptosis in rat kidneys.Jun 19, 2020

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Pubmed Data : Biomed Environ Sci. 2020 Jun 20 ;33(6):454-457. PMID: 32641209

Article Published Date : Jun 19, 2020

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Fluoride Toxicity , Kidney Damage: Chemically-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Renoprotective

Additional Keywords : Proanthocyanidins

Problem Substances : Sodium Fluoride

[+]

Grape seed procyanidin extract can protect against the toxicity of titanium dioxide nanoparticles.Sep 24, 2017

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Pubmed Data : Chem Biol Interact. 2017 Sep 25 ;275:133-144. Epub 2017 Aug 2. PMID: 28780322

[+]

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Pubmed Data : Brain Sci. 2022 Apr 28 ;12(5). Epub 2022 Apr 28. PMID: 35624958

Article Published Date : Apr 27, 2022

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Cognitive Decline/Dysfunction

Pharmacological Actions : Chemoprotective Agents, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Grapeseed exhibits neuroprotective properties against excitotoxicity associated neuronal injury. Jan 01, 2011

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Pubmed Data : PLoS One. 2011;6(1):e14575. Epub 2011 Jan 24. PMID: 21283677

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Excitotoxicity

Pharmacological Actions : Neuroprotective Agents

[+]

Grapeseed extract ameliorates glycation-induced cardiac damage. Nov 01, 2007

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Pubmed Data : J Cardiovasc Pharmacol. 2007 Nov;50(5):503-9. PMID: 18030059

Article Published Date : Nov 01, 2007

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Advanced Glycation End products (AGE), Cardiomyopathy

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[+]

GSSE treatment protected efficiently against all the deleterious effects of diabetes-induced kidney dysfunction.Jul 22, 2016

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Pubmed Data : Biomed Pharmacother. 2016 Jul 23 ;83:584-592. Epub 2016 Jul 23. PMID: 27459114

Article Published Date : Jul 22, 2016

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Diabetic Complications, Kidney Damage, Oxidative Stress

Pharmacological Actions : Antioxidants, Renoprotective

[+]

Hepatoprotective effect of grape seed and skin extract against lithium exposure.Dec 31, 2021

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Pubmed Data : Mol Med Rep. 2017 Dec ;16(6):9393-9400. Epub 2017 Oct 19. PMID: 29152654

Phenolics from commercialized grape extracts prevent early atherosclerotic lesions.Aug 10, 2004

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Pubmed Data : J Agric Food Chem. 2004 Aug 11 ;52(16):5297-302. PMID: 15291511

Article Published Date : Aug 10, 2004

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Arteriosclerosis

Pharmacological Actions : Antioxidants

Additional Keywords : Plant Extracts

[+]

Potential protective effects of red grape seed extract in a rat model of malathion-induced neurotoxicity.Jan 31, 2023

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Pubmed Data : Vet World. 2023 Feb ;16(2):380-385. Epub 2023 Feb 26. PMID: 37042003

The results suggest anti-inflammatory activities of grape seed extract on periodontitis. Feb 28, 2017

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Pubmed Data : J Appl Oral Sci. 2017 Mar-Apr;25(2):121-129. PMID: 28403352

Article Published Date : Feb 28, 2017

Study Type : Animal Study

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Substances : Grape Seed Extract

Diseases : Periodontal Diseases

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Plant Extracts

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These data strongly support grape seed extract as an effective therapeutic approach in multiple sclerosis treatment.Dec 31, 2021

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These results suggested that grape seed proanthocyanidins might be promising phytochemicals against liver cancer.Dec 05, 2019

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Pubmed Data : Foodborne Pathog Dis. 2012 Jun ;9(6):573-8. PMID: 22663188

Article Published Date : May 31, 2012

Study Type : In Vitro Study

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Substances : Cranberry Proanthocyanidins, Grape Seed Extract, Pomegranate Polyphenols

Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Plant Extracts, Proanthocyanidins

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A grape seed extract rich in procyanidins achieves direct and indirect (i.e. cell-mediated) protection of LDL against oxidation.May 01, 2003

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Pubmed Data : Free Radic Res. 2003 May;37(5):573-84. PMID: 12797479

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Pubmed Data : Cells. 2023 Jan 4 ;12(2). Epub 2023 Jan 4. PMID: 36672146

Article Published Date : Jan 03, 2023

Study Type : In Vitro Study

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Substances : Grape Seed Extract

Diseases : Cancers: All

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Proanthocyanidins

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An overview of herbal alternatives in androgenetic alopecia.Apr 12, 2019

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Pubmed Data : J Cosmet Dermatol. 2019 Apr 13. Epub 2019 Apr 13. PMID: 30980598

Article Published Date : Apr 12, 2019

Study Type : Review

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Substances : Grape Seed Extract, Green Tea, Licorice, Rosemary, Saw Palmetto

Diseases : Androgenic Alopecia

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Antimicrobial effectiveness of grape seed extract against Enterococcus faecalis biofilm.Dec 07, 2019

Differential effect of grape seed extract and its active constituent procyanidin B2 3,3″-di-O-gallate against prostate cancer stem cells.Mar 02, 2019

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Pubmed Data : Mol Carcinog. 2019 Mar 3. Epub 2019 Mar 3. PMID: 30828884

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Pubmed Data : Nutrients. 2021 May 17 ;13(5). Epub 2021 May 17. PMID: 34067538

Article Published Date : May 16, 2021

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Pubmed Data : Biol Res. 2002;35(3-4):421-31. PMID: 12462994

Article Published Date : Jan 01, 2002

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Pubmed Data : Res Pharm Sci. 2020 Aug ;15(4):390-400. Epub 2020 Aug 28. PMID: 33312217

Article Published Date : Jul 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Grape Seed Extract

Diseases : Cancers: Drug Resistant, Ovarian Cancer

Pharmacological Actions : Apoptotic

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Grape seed extract remineralizes artificial root caries in vitro. Jan 01, 2005

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Pubmed Data : Indian J Physiol Pharmacol. 2005 Jan;49(1):111-4. PMID: 18819742

Article Published Date : Jan 01, 2005

Study Type : In Vitro Study

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Substances : Grape Seed Extract

Diseases : Dental Caries

Additional Keywords : Remineralization of Root Caries

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Grape seed extract significantly enhanced the growth-inhibitory effects of 5-Fluorouracil by 26%.Dec 31, 2013

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Pubmed Data : PLoS One. 2014 ;9(1):e85184. Epub 2014 Jan 21. PMID: 24465501

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Pubmed Data : Biomed Res Int. 2014 ;2014:127021. Epub 2014 Apr 23. PMID: 24864227

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

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Substances : Grape Seed Extract

Diseases : Candida Infection

Pharmacological Actions : Antifungal Agents

Additional Keywords : Plant Extracts

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Grape seed proanthocyanidin (GSP) enhances the anti cancer effect of interferon on T24 human bladder carcinoma cellsJan 01, 2012

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Pubmed Data : J Cancer. 2012 ;3:107-12. Epub 2012 Mar 1. PMID: 22393334

Article Published Date : Jan 01, 2012

Study Type : In Vitro Study

Additional Links

Substances : Grape Seed Extract, Proanthocyanidins

Diseases : Bladder Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Plant Extracts, Proanthocyanidins

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Grape seed proanthocyanidin could be a potent therapeutic agent to suppress excessive mucus production and RSV viral replication.Jun 06, 2017

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Pubmed Data : J Agric Food Chem. 2017 Jun 7 ;65(22):4472-4483. Epub 2017 May 23. PMID: 28502165

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Pubmed Data : Arch Rheumatol. 2022 Sep ;37(3):393-403. Epub 2022 Jul 22. PMID: 36589610

Article Published Date : Aug 31, 2022

Study Type : In Vitro Study

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Substances : Grape Seed Extract

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Antioxidants

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Grape seed proanthocyanidin extract inhibits DNA and protein damage and labile iron, enzyme, and cancer cell activities.Jan 19, 2022

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Pubmed Data : Sci Rep. 2022 07 20 ;12(1):12393. Epub 2022 Jul 20. PMID: 35859159

Article Published Date : Jan 19, 2022

Study Type : In Vitro Study

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Substances : Grape Seed Extract

Diseases : Breast Cancer, DNA damage, Liver Cancer

Pharmacological Actions : Alpha-amylase inhibitor, Antioxidants, Antiproliferative

Additional Keywords : Plant Extracts, Proanthocyanidins

[+]

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Pubmed Data : Nutr Cancer. 2014 ;66(1):88-96. Epub 2013 Dec 10. PMID: 24325191

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Grape Seed Extract

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Proanthocyanidins

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Grape seed procyanidin extract inhibits cell proliferation by inducing cell cycle arrest and apoptosis in BIU87 cells.Jun 30, 2016

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Pubmed Data : Eur Rev Med Pharmacol Sci. 2016 Jul ;20(15):3282-91. PMID: 27467005

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Pubmed Data : Food Microbiol. 2020 Sep ;90:103461. Epub 2020 Feb 12. PMID: 32336357

Article Published Date : Aug 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Gingerol , Grape Seed Extract

Diseases : Hepatitis A

Pharmacological Actions : Antiviral Agents

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In this review, they have summarized the recent progress on dietary nutraceuticals in reversing multidrug resistance.Dec 31, 2014

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Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(16):6831-9. PMID: 26514453

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Substances : beta-Carotene, Bitter Melon, Capsaicin, Curcumin, EGCG (Epigallocatechin gallate), Fruit: All, Fucoxanthin , Gingerol , Grape Seed Extract, Indole-3-Carbinol, Piperine, Quercetin, Resveratrol, Vegetables: All

Diseases : Cancers: All

Pharmacological Actions : Multidrug Resistance Gene Modulators

Additional Keywords : Multidrug Resistance, Natural Substance/Drug Synergy

[+]

Induction of apoptosis by grape seed extract in oral squamous cell carcinoma.Jul 31, 2013

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Pubmed Data : Foods. 2020 Sep 26 ;9(10). Epub 2020 Sep 26. PMID: 32993186

Article Published Date : Sep 25, 2020

Study Type : In Vitro Study

Additional Links

Substances : Grape Seed Extract

Diseases : Helicobacter Pylori Infection

Pharmacological Actions : Anti-Bacterial Agents

[+]

Quercetin, green tea extract and grape seed extract acted synergistically in combination with lettuce extract against oxidation of peroxidating liposomes.Dec 31, 2015

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Pubmed Data : Food Chem. 2016 Jan 1 ;190:25-32. Epub 2015 May 16. PMID: 26212937

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Pubmed Data : Int J Mol Sci. 2023 Apr 6 ;24(7). Epub 2023 Apr 6. PMID: 37047797

Article Published Date : Apr 05, 2023

Study Type : In Vitro Study

Additional Links

Substances : Grape Seed Extract

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Anti-metastatic

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View the Evidence: 311 Abstracts with Grape Seed Extract Research

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Garlic and grape seed supplement use is inversely associated with hematological malignancies.Jul 29, 2011

Grape seed extract exerted a beneficial impact on blood pressure.Jul 31, 2016

Grape seed extract reduces blood pressure, a cardiovascular risk marker.Aug 01, 2011

The effect of grape products containing polyphenols on C-reactive protein levels.Sep 13, 2020

The effect of grape seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate.Dec 31, 2021

The effect of grape seed extract supplementation on oxidative stress and inflammation.Jun 08, 2021

A combination of polyphenols reduced diastolic pressure by potentiating eNOS activation and nitric oxide production.Jun 09, 2015

A grape seed and bilberry extract reduces blood pressure in individuals at risk of developing type 2 diabetes.Dec 31, 2022

A grape seed extract reduces the inflammatory response and oxidative stress in patients with systemic sclerosis.Aug 01, 2002

A multi-nutrient mixture of soy extract, fish protein polysaccharides, extracts from white tea, grape seed and tomato, vitamins C and E as well as zinc and chamomile extract improves signs of skin aging in post-menopausal women. Oct 01, 2006

A pilot study of a grape seed procyanidin extract for lung cancer chemoprevention.Jul 31, 2019

Acute grape seed extract supplement can be an effective way to decrease cellular membrane damage after eccentric exercise.Jan 19, 2019

An isoflavonoid-rich herbal preparation Karinat may play an important role in the prevention of atherosclerosis progression in postmenopausal women.Dec 31, 2015

Beneficial effects of grape seed extract on malondialdehyde-modified LDL.Mar 31, 2007

Clinical efficacy of grape seed extract as an adjuvant to scaling and root planing in treatment of periodontal pockets.Dec 31, 2020

Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome.Nov 30, 2009

Efficacy of grape seed extract gel in the treatment of chronic periodontitisApr 30, 2018

Grape seed extract alleviates radiation-induced damages in human blood lymphocytes.Jun 30, 2020

Grape seed extract and low calorie diet has favourable effects on anthropometric measurements and inflammatory markers in obese or overweight individuals.Nov 10, 2019

Grape seed extract appears to be an ergogenic nutraceutical that can improve exercise performance in elite athletes.Oct 30, 2022

Grape seed extract can be a dietary supplement to treat augmented blood pressure responses in obese and overweight males at rest and during exercise.May 19, 2021

Grape seed extract for eight weeks had beneficial effects on the plasma GSH, MDA levels, and markers of insulin metabolism of female volleyball players.Aug 31, 2016

Grape seed extract improves insulin concentration and insulin resistance in adolescents with metabolic syndrome.Dec 31, 2020

Grape seed extract in combination with deferasirox ameliorates iron overload, oxidative stress, inflammation, and liver dysfunction in beta thalassemia children.Oct 10, 2023

Grape seed extract may act as an ergogenic aid that can improve O2 delivery to exercising muscles.Dec 31, 2022

Grape seed extract positively modulates blood pressure and perceived stress.Feb 16, 2021

Grape seed extract represents an intervention that may minimize potential increases in the risk of cardiovascular events during exercise in prehypertensives.Apr 30, 2018

Grape seed extract showed complete repair of wounds averagely on day 8 for the treatment group and on day 14 for the placebo group.Apr 30, 2015

Grape seed extract significantly improved markers of inflammation and glycaemia and a sole marker of oxidative stress in obese Type 2 diabetic subjects at high risk of cardiovascular events over a 4-week period, which suggests it may have a therapeutic roMay 01, 2009

Grape seed extract supplementation along with a restricted-calorie diet improves cardiovascular risk factors in obese or overweight adult individuals.Oct 11, 2020

Grape seed extract was found to be safe and to improve blood pressure in people with pre-hypertension.Nov 15, 2015

Grape seed polyphenol extract and cognitive function in healthy young adults.Jan 15, 2020

Grape seed proanthocyanidin extract consumption could help maintain vascular elasticity and normal blood pressure.Nov 19, 2019

Grape seed proanthocyanidin extract had beneficial effects on the progression of carotid atherosclerotic plaques.Jun 30, 2015

Grape seed proanthocyanidin extract is effective in improving the physical and psychological symptoms of menopause while increasing muscle mass and reducing blood pressure.Aug 31, 2014

Grape seed procyanidin extract mediates antineoplastic effects against lung cancer.Nov 30, 2016

Grapeseed procyanidin decreases plasma levels of triglycerides.Aug 01, 2008

GSE and Vitamin C had antioxidative effects and reduced deleterious effects of coronary artery bypass grafting surgery.Dec 31, 2016

Ingestion of biscuits rich in plant-derived phenols significantly lowered the redox potential of urine by 33%. Dec 31, 2014

Niacin-bound chromium and grape seed extract can decrease total cholesterol and LDL levels significantly. Jan 01, 2000

Nrf2 regulates downstream genes by targeting miR-29b in severe asthma and the role of grape seed proanthocyanidin extract.Nov 30, 2022

Oral grape seed proanthocyanidin extract therapy for 1 year improved hard exudates in patients with non-proliferative diabetic retinopathy.Apr 30, 2019

Oral intake of proanthocyanidin-rich extract from grape seeds improves chloasma.Oct 31, 2004

Oral intake of proanthocyanidin-rich grape seed extract up to 2500 mg for 4 weeks was found to be generally safe and well tolerated in humans.Sep 30, 2017

Proanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sitting.Jan 31, 2013

Red grape seed extract may have potential beneficial effects in preventing oxidative stress and atherosclerosis in patients with mild hyperlipidemia.May 12, 2016

The aqueous extracts of the chosen herbal plants showed an acceptable antibacterial efficacy against oral streptococci.Oct 30, 2017

The effect of polyphenol-rich chardonnay seed supplements on peripheral endothelial function.Nov 30, 2020

Combinations of grape seed procyanidin extract and milk thistle silymarin extract against lung cancer.Mar 31, 2023

Grape seed extract attenuates demyelination in experimental autoimmune encephalomyelitis.Apr 30, 2023

A grape seed procyanidin extract ameliorates fructose induced hypertriglyceridemia in rats.Dec 31, 2014

A mixed grape and blueberry extract is safe for dogs to consume.Dec 31, 2015

A multicomponent powder allows the prevention of any metal deposition within the stratum corneum following exposure in a polluted environment.Dec 31, 2017

Accelerated skeletal muscle recovery after in vivo polyphenol administration.Aug 31, 2012

Aged garlic extract and grape seed proanthocyanidin protect against doxorubicin-induced cardiotoxicity.Aug 01, 2009

Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a D-galactose-induced aging mouse model.Feb 06, 2022

Anthocyanins may exhibit protective effects against high glucose induced renal injury in diabetic nephropathy via antioxidant activity.Feb 28, 2018

Bioactive dietary polyphenol preparations could be potential therapeutic agents in promoting resilience against sleep deprivation-induced cognitive dysfunction.Jul 29, 2015

Black grape extract could be considered as a suitable candidate for treating or preventing ulcerative colitis.Dec 31, 2019

Central administration of ampelopsin A isolated from Vitis vinifera ameliorates cognitive and memory function.May 23, 2021

Chronic consumption of a moderate dose of grape seed proanthocyanidin extract can correct an energy imbalance in a situation of diet-induced obesity, thereby improving the mitochondrial function and thermogenic capacity.Jun 28, 2011

Consuming grape seed extract in the elderly can potentially alleviate the age-related reduction of hippocampal neurogenesis and synaptogenesis.May 09, 2021

Dietary constituents inhibit chemically-induced DNA and hemoglobin adductions associated with cancer.Mar 01, 2003

Dietary feeding of grape seed extract prevents intestinal tumorigenesis in mice.Jan 01, 2010

Dietary grape seed proanthocyanidin extract may be a protector against lead-induced metabolic dysfunction and liver injury.May 31, 2018

Dietary grape seed procyanidin extract protects against lead-induced heart injury.Nov 30, 2018

Effect of a combination of pea protein, grape seed extract and lactic acid in an in vivo model of bacterial vaginosis.Feb 16, 2023

Effect of grape seed extract on oxidative stress and pathological changes of aorta in rats with chronic periodontitis and arteriosclerosis.Nov 30, 2022

Effect of pea protein plus grape seed dry extract on a murine model of Candida albicans induced vaginitis.Dec 31, 2017

Effects of acute grape seed extract supplementation on hemodynamics in normal body weight and obese males. Dec 31, 2019

Effects of grape polyphenols on the Life span and neuroinflammatory alterations related to neurodegenerative disease-like disturbances.Nov 15, 2020

Effects of grape seed proanthocyanidin B2 pretreatment on oxidative stress and renal tubular epithelial cell apoptosis after renal ischemia.Sep 03, 2020

Grape Seed Extract

View the Evidence:
311 Abstracts with Grape Seed Extract Research