Harmine

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1 Diseases Researched for Harmine
NameACCKFocus
Breast Cancer11Locked
3 Pharmacological Actions Researched for Harmine
NameACCKFocus
Antiproliferative 11Locked
Apoptotic11Locked
Bcl-2 protein down-regulation11Locked

View the Evidence:
29 Abstracts with Harmine Research

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Harmine alleviates atherogenesis by inhibiting disturbed flow-mediated endothelial activation via protein tyrosine phosphatase PTPN14 and YAP.Dec 31, 2020

Pubmed Data : Br J Pharmacol. 2021 04 ;178(7):1524-1540. Epub 2021 Feb 15. PMID: 33474722
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Harmine
Diseases : Atherosclerosis
Pharmacological Actions : Anti-atherogenic
[+]

Harmine ameliorates cognitive impairment by inhibiting NLRP3 inflammasome activation.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:535. Epub 2020 May 1. PMID: 32425784
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Harmine
Diseases : Diabetes: Cognitive Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Brain-derived neurotrophic factor modulator, Neuroprotective Agents
[+]

Harmine is an effective therapeutic small molecule for the treatment of cardiac hypertrophy.Mar 29, 2021

Pubmed Data : Acta Pharmacol Sin. 2021 Mar 30. Epub 2021 Mar 30. PMID: 33785860
Article Published Date : Mar 29, 2021
Study Type : Animal Study
Additional Links
Substances : Harmine
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, NF-kappaB Inhibitor
[+]

Harmine mitigates cisplatin-induced renal injury.Jul 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Res Pharm Sci. 2022 Aug ;17(4):417-427. Epub 2022 Jul 14. PMID: 36034080
Article Published Date : Jul 31, 2022
Study Type : Animal Study
Additional Links
Substances : Harmine
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Harmine protects mercuric chloride kidney-induced injury by antioxidant activity in male mice: a biochemical and histological study.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Res Pharm Sci. 2020 Dec ;15(6):541-550. Epub 2020 Nov 27. PMID: 33828597
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Harmine
Diseases : Kidney Damage: Chemically-Induced
Pharmacological Actions : Antioxidants, Renoprotective
Problem Substances : Mercury
[+]

Harmine shows therapeutic activity on nicotine-induced liver failure in mice.May 02, 2019

Pubmed Data : Histol Histopathol. 2019 May 3:18122. Epub 2019 May 3. PMID: 31049922
Article Published Date : May 02, 2019
Study Type : Animal Study
Additional Links
Substances : Harmine
Diseases : Chemically-Induced Liver Damage, Nicotine/Tobacco Toxicity
Pharmacological Actions : Hepatoprotective
[+]

Harmine suppresses hyper-activated Ras-MAPK pathway by selectively targeting oncogenic mutated Ras/Raf.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2019 ;19:159. Epub 2019 Jun 11. PMID: 31198408
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Harmine
Diseases : Cancers: All
Pharmacological Actions : Chemotherapeutic
[+]

It seems that harmine administration improved kidney injury induced by nicotine.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Prev Med. 2019 ;10:97. Epub 2019 Jun 7. PMID: 31360344
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Harmine
Diseases : Kidney Damage: Chemically-Induced, Nicotine/Tobacco Toxicity
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Renoprotective
[+]

Structure-activity insights of harmine targeting DNA, ROS inducing cytotoxicity with PARP mediated apoptosis against cervical cancer, anti-biofilm formation.Jan 21, 2021

Pubmed Data : J Biomol Struct Dyn. 2021 Jan 22:1-23. Epub 2021 Jan 22. PMID: 33480316
Article Published Date : Jan 21, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Harmine
Diseases : Cervical Cancer, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation
[+]

Enhanced glioblastoma selectivity of harmine via the albumin carrier. Mar 31, 2022

Pubmed Data : J Biomed Nanotechnol. 2022 Apr 1 ;18(4):1052-1063. PMID: 35854453
Article Published Date : Mar 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Glioblastoma
Pharmacological Actions : Antineoplastic Agents
[+]

Harmine alleviated sepsis-induced cardiac dysfunction.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Dev Biol. 2021 ;9:792257. Epub 2022 Jan 17. PMID: 35111758
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Sepsis
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cardioprotective, NF-kappaB Inhibitor, STAT3 Inhibitor
[+]

Harmine and piperlongumine revert TRIB2-mediated drug resistance.Dec 08, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancers (Basel). 2020 Dec 9 ;12(12). Epub 2020 Dec 9. PMID: 33316942
Article Published Date : Dec 08, 2020
Study Type : In Vitro Study
Additional Links
Substances : Harmine, Piperlongumine
Diseases : Cancers: Drug Resistant
Pharmacological Actions : Chemotherapeutic
[+]

Harmine hydrochloride triggers G2/M cell cycle arrest and apoptosis in HCT116 cells.Dec 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Prev Nutr Food Sci. 2021 Dec 31 ;26(4):445-452. PMID: 35047441
Article Published Date : Dec 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Harmine induces anticancer activity in breast cancer cells via targeting TAZ.May 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2019 Jun ;54(6):1995-2004. Epub 2019 Apr 9. PMID: 31081045
Article Published Date : May 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Harmine inhibits breast cancer cell migration and invasion by inducing the degradation of Twist1.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2021 ;16(2):e0247652. Epub 2021 Feb 24. PMID: 33626096
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

Harmine inhibits the proliferation and migration of glioblastoma cells via the FAK/AKT pathway.Mar 31, 2021

Pubmed Data : Life Sci. 2021 Apr 1 ;270:119112. Epub 2021 Jan 26. PMID: 33508300
Article Published Date : Mar 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Glioblastoma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Harmine may provide potential therapeutic targets for bone loss diseases. Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2021 06 ;25(12):5525-5533. Epub 2021 May 7. PMID: 33960660
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
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Harmine might have potential in curing human bladder tumor.May 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Rep. 2019 May 31 ;39(5). Epub 2019 May 2. PMID: 30910851
Article Published Date : May 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Bladder Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Apoptotic, Vascular Endothelial Growth Factor Inhibitors
[+]

Harmine reinforces the effects of regorafenib on suppressing cell proliferation and inducing apoptosis in liver cancer cells.Feb 28, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2022 Mar ;23(3):209. Epub 2022 Jan 7. PMID: 35126712
Article Published Date : Feb 28, 2022
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Harmine suppresses breast cancer cell migration and invasion.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Cancer Res. 2022 ;12(6):2612-2626. Epub 2022 Jun 15. PMID: 35812064
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

Harmine suppresses collagen production in hepatic stellate cells by inhibiting DYRK1B.Jan 15, 2022

Pubmed Data : Biochem Biophys Res Commun. 2022 04 16 ;600:136-141. Epub 2022 Feb 16. PMID: 35219102
Article Published Date : Jan 15, 2022
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Harmine suppresses the proliferation of pancreatic cancer cells and sensitizes pancreatic cancer to gemcitabine treatment.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2019 ;12:4585-4593. Epub 2019 Jun 12. PMID: 31354292
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Improving anti-tumor outcomes for colorectal cancer therapy through in situ thermosensitive gel loading harmine.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2020 ;12(5):1658-1671. Epub 2020 May 15. PMID: 32509167
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative
[+]

In vitro effect of harmine alkaloid and its N-methyl derivatives against Toxoplasma gondii.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Microbiol. 2021 ;12:716534. Epub 2021 Aug 5. PMID: 34421876
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Toxoplasma gondii Infection
Pharmacological Actions : Antiparasitic Agents
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In vitro effects of harmine against Echinococcus granulosus protoscoleces by stimulating DNA damage.Jun 30, 2021

Pubmed Data : Exp Parasitol. 2021 Jul-Aug;226-227:108121. Epub 2021 Jun 9. PMID: 34097889
Article Published Date : Jun 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Parasitic Diseases
Pharmacological Actions : Antiparasitic Agents
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Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation.Jul 31, 2019

Pubmed Data : Phytomedicine. 2019 Aug ;61:152842. Epub 2019 Jan 30. PMID: 31048127
Article Published Date : Jul 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
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Preparation and effect against cervical cancer invasion in vitro of harmine-loaded photosensitive liposomes.Apr 30, 2022

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2022 May ;47(10):2643-2651. PMID: 35718482
Article Published Date : Apr 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative
[+]

The impact of harmine hydrochloride on growth, apoptosis and migration, invasion of gastric cancer cells.Jul 31, 2020

Pubmed Data : Pathol Res Pract. 2020 Aug ;216(8):152995. Epub 2020 Apr 25. PMID: 32402536
Article Published Date : Jul 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Gastric Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor, P21 Activation, Survivin Down-Regulation
[+]

β-carbolines are multi-target antidepressant compounds and may be useful in the treatment of depressive disorders.Aug 31, 2019

Pubmed Data : Fitoterapia. 2019 Sep ;137:104196. Epub 2019 Jun 6. PMID: 31175948
Article Published Date : Aug 31, 2019
Study Type : Review
Additional Links
Substances : Harmine
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Neurogenesis

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