Hawthorn

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87 Diseases Researched for Hawthorn
NameACCKFocus
Heart Failure744Locked
Congestive Heart Failure321Locked
Oxidative Stress1521Locked
Diabetes Mellitus: Type 2517Locked
DNA damage312Locked
Inflammation912Locked
Coronary Artery Disease211Locked
Hypertension611Locked
Lipid Peroxidation211Locked
Radiation Induced Illness211Locked
C-Reactive Protein110Locked
Hyperlipidemia610Locked
Left Ventricular Dysfunction110Locked
Nonalcoholic fatty liver disease (NAFLD)610Locked
Alzheimer's Disease58Locked
Myocardial Ischemia47Locked
Obesity47Locked
Breast Cancer: Triple Negative 26Locked
Hypercholesterolemia36Locked
High Fat Diet35Locked
Aging24Locked
Chemotherapy-Induced Toxicity: Doxorubicin24Locked
Colitis24Locked
Depression24Locked
Diabetes Mellitus: Type 124Locked
Diabetic Nephropathy24Locked
Dysbiosis24Locked
Ultraviolet Radiation Induced Damage24Locked
Alcoholic Liver Disease23Locked
Arteriosclerosis23Locked
Atherosclerosis23Locked
Cardiovascular Diseases33Locked
Chemically-Induced Liver Damage23Locked
Dyslipidemias23Locked
High Cholesterol23Locked
High Fructose Diet23Locked
Hyperglycemia33Locked
Liver Cancer33Locked
Aging Skin12Locked
Arrhythmias: Cardiac12Locked
Breast Cancer22Locked
Cholesterol: Oxidation12Locked
Colorectal Cancer22Locked
Constipation12Locked
Diabetes Mellitus: Type 2: Prevention12Locked
Diabetes: Cognitive Dysfunction12Locked
Diabetic Complications12Locked
Diarrhea12Locked
Gastric Ulcer12Locked
Glyphosate Toxicity12Locked
Gram-Positive Bacterial Infections12Locked
Hair Loss12Locked
Hydrogen Peroxide Induced Toxicity22Locked
Insulin Resistance22Locked
Liver Cirrhosis12Locked
Liver Fibrosis12Locked
Liver Steatosis12Locked
Metabolic Diseases12Locked
Neurodegenerative Diseases22Locked
Osteoarthritis12Locked
Osteoporosis12Locked
Pesticide Toxicity 12Locked
Space Flight Associated Adverse Changes12Locked
Spinal Cord Injuries12Locked
Ulcerative Colitis12Locked
Advanced Glycation End products (AGE)11Locked
Alcohol Toxicity 11Locked
Arterial Calcification11Locked
Brain Inflammation 11Locked
Brain: Oxidative Stress11Locked
Cancers: All11Locked
Congestive Heart Failure: NYHA functional class II11Locked
Diabetes: Oxidative Stress11Locked
Diabetic Retinopathy11Locked
Gastrointestinal Cancer11Locked
Gaucher Disease11Locked
Glioblastoma11Locked
Heart Disease11Locked
Lipid Metabolism: Abnormalities11Locked
Lipopolysaccharide-Induced Toxicity11Locked
Liver Damage11Locked
Lung Cancer11Locked
Metabolic Syndrome X11Locked
Myocardial Infarction11Locked
Promyelocytic leukemia 11Locked
Radiation Induced Illness: Bone Marrow11Locked
Tay-Sachs Disease11Locked
61 Pharmacological Actions Researched for Hawthorn
NameACCKFocus
Antioxidants4268Locked
Anti-Inflammatory Agents2641Locked
Hypolipidemic1734Locked
Hepatoprotective1423Locked
Neuroprotective Agents1218Locked
Cardioprotective1116Locked
Gastrointestinal Agents814Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor712Locked
Radioprotective211Locked
Antihypertensive Agents510Locked
Interleukin-1 beta downregulation610Locked
Interleukin-6 Downregulation610Locked
Antiproliferative 59Locked
Hypoglycemic Agents69Locked
Apoptotic77Locked
Wnt/β-catenin signaling pathway modulation27Locked
Anticholesteremic Agents36Locked
Nrf2 activation36Locked
NF-kappaB Inhibitor35Locked
Superoxide Dismutase Up-regulation35Locked
Anti-Apoptotic34Locked
Antidepressive Agents24Locked
Chemoprotective Agents24Locked
Heme oxygenase-1 up-regulation24Locked
Immunomodulatory34Locked
Photoprotective24Locked
Anti-Fibrotic23Locked
Malondialdehyde Down-regulation23Locked
Vasodilator Agents33Locked
Anti-atherogenic12Locked
Antidiarrheals12Locked
Bax/Bcl2 ratio: Increase12Locked
Chemopreventive22Locked
Cyclooxygenase 2 Inhibitors12Locked
Enzyme Inhibitors12Locked
Interleukin-1 alpha downregulation12Locked
Matrix metalloproteinase-1 (MMP-1) inhibitor12Locked
MicroRNA modulator12Locked
Osteoprotective 12Locked
Renoprotective12Locked
SIRT1 Activator12Locked
Transforming growth factor beta (TGF-β) upregulation12Locked
anti-inflammatory12Locked
Acetylcholinesterase Inhibitor11Locked
Alpha-glucosidase inhibitor 11Locked
Angiogenesis Inducing Agents11Locked
Anti-Glycation Agents11Locked
Anticoagulants11Locked
Antineoplastic Agents11Locked
Caspase-3 Activation11Locked
Caspase-9 Activation11Locked
Cell cycle arrest11Locked
Chemosensitizer11Locked
Chemotherapeutic11Locked
Cyclin D1 Down-Regulation11Locked
Insulin Sensitizers11Locked
Interleukin-8 downregulation11Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor11Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor11Locked
Pancreato Protective Agents11Locked
Regenerative11Locked

View the Evidence:
121 Abstracts with Hawthorn Research

[+]

C. laevigata decreased neutrophil elastase and showed a trend to lower LDL-C.Jun 14, 2011

Pubmed Data : Phytomedicine. 2011 Jun 15 ;18(8-9):769-75. Epub 2011 Jan 15. PMID: 21242072
Article Published Date : Jun 14, 2011
Study Type : Human Study
Additional Links
Substances : Hawthorn
Diseases : C-Reactive Protein, Coronary Artery Disease, Diabetes Mellitus: Type 2, Lipid Peroxidation
Pharmacological Actions : Hypolipidemic
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Hawthorn (Crataegus) reduces the incidence of sudden cardiac death in patients with less compromised left ventricular function.Dec 01, 2008

Pubmed Data : Eur J Heart Fail. 2008 Dec;10(12):1255-63. Epub 2008 Nov 18. PMID: 19019730
Article Published Date : Dec 01, 2008
Study Type : Human Study
Additional Links
Substances : Hawthorn
Diseases : Heart Failure, Left Ventricular Dysfunction
Additional Keywords : Plant Extracts, Risk Reduction
[+]

Hawthorn berry extract is safe and effective in improving exercise tolerance and quality of life in patients with congestive heart failure Oct 01, 2001

Pubmed Data : Arzneimittelforschung. 2001 Oct;51(10):793-8. PMID: 11715631
Article Published Date : Oct 01, 2001
Study Type : Human Study
Additional Links
Substances : Hawthorn
Diseases : Congestive Heart Failure, Heart Failure
[+]

Hawthorn berry improves symptoms in patients with congestive heart failure. Sep 26, 2007

Pubmed Data : JAMA. 2007 Sep 26;298(12):1420-8. PMID: 12833999
Article Published Date : Sep 26, 2007
Study Type : Human Study
Additional Links
Substances : Hawthorn
Diseases : Congestive Heart Failure
[+]

Hawthorn protects against gamma radiation induced genotoxicity in human blood lymphocytes.Feb 01, 2009

Pubmed Data : Radiat Environ Biophys. 2009 Feb;48(1):95-8. Epub 2008 Sep 4. PMID: 18769933
Article Published Date : Feb 01, 2009
Study Type : Human Study
Additional Links
Substances : Hawthorn
Diseases : DNA damage, Radiation Induced Illness
Pharmacological Actions : Radioprotective
Additional Keywords : Plant Extracts
[+]

Hawthorn provides benefits as an adjunctive treatment for chronic heart failure. - Article 1Jun 01, 2003

Pubmed Data : Am J Med. 2003 Jun 1;114(8):665-74. PMID: 12798455
Article Published Date : Jun 01, 2003
Study Type : Human Study
Additional Links
Substances : Hawthorn
Diseases : Heart Failure
[+]

Hawthorn provides benefits as an adjunctive treatment for chronic heart failure. - Article 2Jan 23, 2008

Pubmed Data : Cochrane Database Syst Rev. 2008 Jan 23;(1):CD005312. PMID: 18254076
Article Published Date : Jan 23, 2008
Study Type : Human Study
Additional Links
Substances : Hawthorn
Diseases : Heart Failure
[+]

In vitro anti-cancer effect of Crataegus oxyacantha berry extract on hormone receptor positive and triple negative breast cancers.Mar 08, 2022

Pubmed Data : Appl Biochem Biotechnol. 2022 Mar 9. Epub 2022 Mar 9. PMID: 35262883
Article Published Date : Mar 08, 2022
Study Type : Human In Vitro
Additional Links
Substances : Hawthorn
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Wnt/β-catenin signaling pathway modulation
Additional Keywords : Cancer Stem Cells
[+]

Hyperoside Prevents Aβ42-Induced Neurotoxicity in PC12 Cells and Caenorhabditis elegans.Nov 30, 2023

Pubmed Data : Mol Neurobiol. 2023 Dec ;60(12):7136-7150. Epub 2023 Aug 3. PMID: 37535309
Article Published Date : Nov 30, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Alzheimer's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

A herbal complex is an effective herbal formulation in the attenuation of obesity and obesity-induced metabolic dysfunction including NAFLD.Jan 07, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Jan 8 ;26(2). Epub 2021 Jan 8. PMID: 33435558
Article Published Date : Jan 07, 2021
Study Type : Animal Study
Additional Links
Substances : Cinnamon, Hawthorn, Raspberry
Diseases : Metabolic Diseases, Nonalcoholic fatty liver disease (NAFLD), Obesity
Pharmacological Actions : Enzyme Inhibitors, Hepatoprotective, Hypolipidemic
[+]

A phenol-rich fraction of hawthorn fruit exhibited satisfactory hypolipidemic and antioxidant effects.Sep 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Mag. 2017 Oct-Dec;13(52):725-731. Epub 2017 Nov 13. PMID: 29200740
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Hyperlipidemia
Pharmacological Actions : Antioxidants, Hypolipidemic
[+]

Antihypertensive effects of hydroalcoholic extract of Crataegus Azarolus subspecies Aronia fruit in rats with renovascular hypertension.Apr 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Med Sci. 2017 May ;42(3):266-274. PMID: 28533575
Article Published Date : Apr 30, 2017
Study Type : Animal Study
Additional Links
Substances : Chokeberry, Hawthorn
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
[+]

Anxiolytic and antidepressants' effect of Crataegus pinnatifida.Jan 18, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Transl Psychiatry. 2022 05 19 ;12(1):208. Epub 2022 May 19. PMID: 35589704
Article Published Date : Jan 18, 2022
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
[+]

Astragalus polysaccharides combined with Crataegus flavonoids may facilitate the treatment of type 1 or 2 diabetes.Apr 14, 2016

Pubmed Data : Mol Med Rep. 2016 Apr 15. Epub 2016 Apr 15. PMID: 27081750
Article Published Date : Apr 14, 2016
Study Type : Animal Study
Additional Links
Substances : Astragalus, Hawthorn
Diseases : Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 2
Pharmacological Actions : Anti-Inflammatory Agents, Hypoglycemic Agents
Additional Keywords : Natural Substance Synergy
[+]

Beneficial effects of crataegus oxyacantha extract on neurobehavioral deficits and brain tissue damages induced by an insecticide mixtures.May 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jun ;114:108795. Epub 2019 Mar 22. PMID: 30909143
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Pesticide Toxicity
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Chlorpyrifos, Deltamethrin
[+]

C. aronia exhibits therapeutic and protective effects on NAFLD in an animal model.Jul 15, 2016

Pubmed Data : Arch Physiol Biochem. 2016 Jul 16:1-8. Epub 2016 Jul 16. PMID: 27424611
Article Published Date : Jul 15, 2016
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Antioxidants, Hepatoprotective, Hypolipidemic
Additional Keywords : Risk Reduction
[+]

C. aronia inhibits high fat diet-induced vascular inflammation.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2019 Dec ;57(1):38-48. PMID: 30702358
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Cholesterol: Oxidation, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

C. oxyacantha has both a therapeutic and a protective effect for NAFLD.May 01, 2018

Pubmed Data : Drug Res (Stuttg). 2018 May 2. Epub 2018 May 2. PMID: 29719880
Article Published Date : May 01, 2018
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Antioxidants, Hepatoprotective
[+]

Cardioprotective effect of resistance training and Crataegus oxyacantha extract on ischemia reperfusion-induced oxidative stress in diabetic rats.Mar 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Apr ;100:455-460. Epub 2018 Feb 22. PMID: 29477090
Article Published Date : Mar 31, 2018
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Diabetic Complications, Myocardial Ischemia
Therapeutic Actions : Exercise: Resistance Training
Pharmacological Actions : Antioxidants, Cardioprotective
Additional Keywords : Plant Extracts
[+]

Chemical basis of hawthorn processed with honey protecting against myocardial ischaemia.Mar 31, 2020

Pubmed Data : Food Funct. 2020 Apr 1 ;11(4):3134-3143. Epub 2020 Mar 24. PMID: 32207479
Article Published Date : Mar 31, 2020
Study Type : Animal Study
Additional Links
Substances : Hawthorn, Honey
Diseases : Myocardial Ischemia
Pharmacological Actions : Cardioprotective
Additional Keywords : Plant Extracts
[+]

Chemoprevention with a tea from hawthorn leaves and flowers attenuates colitis.Jan 29, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Chem X. 2021 12 30 ;12:100139. Epub 2021 Oct 7. PMID: 34712949
Article Published Date : Jan 29, 2021
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Chinese hawthorn fruit reduces inflammation and oxidative stress in rats with doxorubicin-Induced chronic heart failure.Nov 23, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2020 Nov 24 ;26:e926654. Epub 2020 Nov 24. PMID: 33232307
Article Published Date : Nov 23, 2020
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Chemoprotective Agents, Interleukin-1 beta downregulation
[+]

Chlorogenic acid and Crataegus pinnatifida extracts prevented depressive behaviour and thereby have potential as natural antidepressants.Jun 11, 2018

Pubmed Data : Mol Nutr Food Res. 2018 Jun 12:e1800029. Epub 2018 Jun 12. PMID: 29893510
Article Published Date : Jun 11, 2018
Study Type : Animal Study
Additional Links
Substances : Chlorogenic Acid, Hawthorn
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
[+]

Corosolic acid ameliorates non-alcoholic steatohepatitis induced by high-fat diet and carbon tetrachloride.Aug 31, 2021

Pubmed Data : Phytother Res. 2021 Sep ;35(9):5214-5226. Epub 2021 Jul 2. PMID: 34213784
Article Published Date : Aug 31, 2021
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : High Fat Diet, Liver Cirrhosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : anti-inflammatory, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Transforming growth factor beta (TGF-β) upregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crataegus aronia prevents high-fat diet-induced hepatic steatosis.Jan 10, 2021

Pubmed Data : J Food Biochem. 2021 11 ;45(11):e13945. Epub 2021 Sep 29. PMID: 34585409
Article Published Date : Jan 10, 2021
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : High Fat Diet, Liver Steatosis
Pharmacological Actions : Hepatoprotective
[+]

Crataegus azarolus berry extract protected against acetic acid-induced ulcerative colitis.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Dose Response. 2024 ;22(1):15593258241226890. Epub 2024 Jan 10. PMID: 38223297
Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Gastrointestinal Agents
[+]

Crataegus pinnatifida Bunge could be a potential alternative medicine for bone diseases.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:5521562. Epub 2021 Mar 27. PMID: 33859705
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
[+]

Crataegus pinnatifida polysaccharide alleviates colitis via modulation of gut microbiota and SCFAs metabolism.Mar 23, 2021

Pubmed Data : Int J Biol Macromol. 2021 Mar 24 ;181:357-368. Epub 2021 Mar 24. PMID: 33774071
Article Published Date : Mar 23, 2021
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crataegus sinaica defatted methanolic extract ameliorated monosodium iodoacetate-induced oxidative stress andinhibited inflammation.Sep 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Res Pharm Sci. 2022 Oct ;17(5):493-507. Epub 2022 Sep 8. PMID: 36386489
Article Published Date : Sep 30, 2022
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : IBRO Rep. 2019 Dec ;7:90-96. Epub 2019 Oct 22. PMID: 31720488
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Diabetes: Cognitive Dysfunction
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic, Neuroprotective Agents
[+]

Effect of flavonoids in hawthorn and vitamin C prevents hypertension in rats induced by heat exposure.Jan 26, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2022 Jan 27 ;27(3). Epub 2022 Jan 27. PMID: 35164138
Article Published Date : Jan 26, 2022
Study Type : Animal Study
Additional Links
Substances : Hawthorn, Vitamin C
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents, Antioxidants
Additional Keywords : Natural Substance Synergy
[+]

Effects of hawthorn seed oil on plasma cholesterol and gut microbiota.Aug 11, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Metab (Lond). 2022 Aug 12 ;19(1):55. Epub 2022 Aug 12. PMID: 35962418
Article Published Date : Aug 11, 2022
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Dysbiosis, Hypercholesterolemia
Pharmacological Actions : Anticholesteremic Agents, Gastrointestinal Agents
[+]

Hair growth activity of Crataegus pinnatifida on C57BL/6 mouse model.Aug 31, 2013

Pubmed Data : Phytother Res. 2013 Sep ;27(9):1352-7. Epub 2012 Nov 12. PMID: 23148028
Article Published Date : Aug 31, 2013
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Hair Loss
Pharmacological Actions : Anti-Apoptotic, Bax/Bcl2 ratio: Increase
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Hawthorn and kiwi fruit extracts are superior to simvastatin in lowering cholesterol in mice fed a high cholesterol diet.Jan 01, 2009

Pubmed Data : Am J Chin Med. 2009;37(5):903-8. PMID: 19885950
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Hawthorn, Kiwifruit
Diseases : Arteriosclerosis, Hyperlipidemia
Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic
Additional Keywords : Plant Extracts, Superiority of Natural Substances versus Drugs
[+]

Hawthorn and Rosemary treatments have different mechanisms of action; however they show hepatoprotective effect against alcoholic liver disease.Jun 30, 2019

Pubmed Data : Altern Ther Health Med. 2019 Jul ;25(4):54-63. PMID: 31202212
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Hawthorn, Rosemary
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
[+]

Hawthorn could partially restore liver histomorphology and has anti-hypertensive effect by regulating lipid metabolism.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:963280. Epub 2022 Aug 9. PMID: 36016567
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents, Hypolipidemic
[+]

Hawthorn demonstrates a modest beneficial effects on cardiac remodeling and function during long-term, pressure overload-induced heart failure in rats.Jun 01, 2009

Pubmed Data : Pharmacotherapy. 2009 Jun;29(6):639-48. PMID: 19476417
Article Published Date : Jun 01, 2009
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Heart Failure
Additional Keywords : Plant Extracts
[+]

Hawthorn extract could have protective effects in ovariectomized rats.May 12, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2016 May 13 ;8(5). Epub 2016 May 13. PMID: 27187458
Article Published Date : May 12, 2016
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Ovariectomy-Induced Changes, Plant Extracts
[+]

Hawthorn extract has the potential to become a functional food or an alternative therapy for hypertension.May 19, 2024

Pubmed Data : Food Funct. 2024 May 20 ;15(10):5627-5640. Epub 2024 May 20. PMID: 38722076
Article Published Date : May 19, 2024
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
Additional Keywords : Plant Extracts
[+]

Hawthorn extract represents a useful agent for the prevention or treatment of T2DM.Mar 22, 2017

Pubmed Data : J Sci Food Agric. 2017 Mar 23. Epub 2017 Mar 23. PMID: 28337770
Article Published Date : Mar 22, 2017
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Diabetes Mellitus: Type 2, Diabetes Mellitus: Type 2: Prevention
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Diabetes mellitus: Type 2, Diabetes Mellitus: Type 2: Prevention, Hawthorn, Hypoglycemic Agents
[+]

Hawthorn extracts are able to protect from hypercholesterolemia-induced oxidative stress and hepatic injuries.Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2015 Jul ;18(7):691-9. PMID: 26361538
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Hypercholesterolemia, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
[+]

Hawthorn flower extract has hypotensive and potential antiarrhtymic action. Apr 01, 2005

Pubmed Data : Helicobacter. 2005 Apr;10(2):139-45. PMID: 10960896
Article Published Date : Apr 01, 2005
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Arrhythmias: Cardiac
[+]

Hawthorn fruit acid consumption attenuates hyperlipidemia-associated oxidative damage in rats.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Nutr. 2022 ;9:936229. Epub 2022 Aug 3. PMID: 35990322
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Hyperlipidemia
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Hawthorn fruit extract ameliorates H2O2-induced oxidative damage in neuronal PC12 cells and prolongs the lifespan.Oct 16, 2022

Pubmed Data : Food Funct. 2022 Oct 17 ;13(20):10680-10694. Epub 2022 Oct 17. PMID: 36172739
Article Published Date : Oct 16, 2022
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Aging, Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

Hawthorn fruit, especially its peel, is an excellent source of natural chemopreventive agents in the treatment of liver disorders.Aug 12, 2016

Pubmed Data : Chem Biol Interact. 2016 Aug 13. Epub 2016 Aug 13. PMID: 27531227
Article Published Date : Aug 12, 2016
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Dyslipidemias, High Fructose Diet, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Hawthorn has anti-inflammatory, gastroprotective, free-radical-scavenging, and antimicrobial activities. Sep 10, 2008

Pubmed Data : J Agric Food Chem. 2008 Sep 10;56(17):7700-9. Epub 2008 Aug 13. PMID: 18698794
Article Published Date : Sep 10, 2008
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Gastric Ulcer, Gram-Positive Bacterial Infections, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Drug: Ranitidine, Histamine H2-Receptor Antagonist Alternatives, Natural Substances Versus Drugs, Plant Extracts
[+]

Hawthorn herbal preparation from Crataegus oxyacantha attenuates carbon tetrachloride-induced hepatic fibrosis.Nov 23, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Nov 24 ;9(12). Epub 2020 Nov 24. PMID: 33255507
Article Published Date : Nov 23, 2020
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Hawthorn leave flavonoids can slow down the development of atherosclerosis in apoE knockout mice.Feb 22, 2017

Pubmed Data : J Ethnopharmacol. 2017 Feb 23 ;198:479-488. Epub 2017 Jan 21. PMID: 28119096
Article Published Date : Feb 22, 2017
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Atherosclerosis
Pharmacological Actions : Anti-atherogenic
Additional Keywords : Anti-atherogenic, Atherosclerosis, Hawthorn
[+]

Hawthorn leaves flavonoids attenuate cardiac remodeling induced by simulated microgravity.Nov 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2023 Dec ;61(1):683-695. PMID: 37096968
Article Published Date : Nov 30, 2023
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Hawthorn
Diseases : Space Flight Associated Adverse Changes
Pharmacological Actions : Cardioprotective
[+]

Hawthorn polyphenol extract could be used as a functional food component in the adjuvant treatment of T2D.Mar 31, 2021

Pubmed Data : Food Res Int. 2021 Apr ;142:110239. Epub 2021 Feb 25. PMID: 33773689
Article Published Date : Mar 31, 2021
Study Type : Animal Study
Additional Links
Substances : Hawthorn, Polyphenols
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic, Interleukin-6 Downregulation, NF-kappaB Inhibitor, SIRT1 Activator, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Wnt/β-catenin signaling pathway modulation
[+]

Hawthorn polyphenol extract inhibits UVB-induced skin photoaging.Aug 14, 2018

Pubmed Data : J Agric Food Chem. 2018 Aug 15 ;66(32):8537-8546. Epub 2018 Jul 31. PMID: 30032605
Article Published Date : Aug 14, 2018
Study Type : Animal Study
Additional Links
Substances : Hawthorn, Polyphenols
Diseases : Aging Skin, Ultraviolet Radiation Induced Damage
Therapeutic Actions : Sunlight exposure
Pharmacological Actions : Matrix metalloproteinase-1 (MMP-1) inhibitor, Photoprotective
Additional Keywords : Plant Extracts
[+]

Hawthorn-leaf flavonoid alleviate intestinal health and microbial dysbiosis problems induced by glyphosate.Aug 21, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ecotoxicol Environ Saf. 2024 Aug 22 ;284:116901. Epub 2024 Aug 22. PMID: 39178762
Article Published Date : Aug 21, 2024
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Dysbiosis, Glyphosate Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Problem Substances : Glyphosate
[+]

Hawthorne leaf flavonoids prevent oxidative stress injury of renal tissues in rats with diabetic kidney disease.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Pathol. 2019 ;12(9):3440-3446. Epub 2019 Sep 1. PMID: 31934188
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Diabetic Nephropathy
Pharmacological Actions : Antioxidants, Renoprotective
[+]

Hepatoprotective effects of Algerian Crataegus oxyacantha leaves.Jul 28, 2018

Pubmed Data : Recent Pat Food Nutr Agric. 2018 Jul 29. Epub 2018 Jul 29. PMID: 30058501
Article Published Date : Jul 28, 2018
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Hepatoprotective
[+]

In vivo effects of Crataegus pinnatifida extract for healthy longevity. May 27, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Microbiol Biotechnol. 2023 May 28 ;33(5):680-686. Epub 2023 Mar 10. PMID: 37218439
Article Published Date : May 27, 2023
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Aging
[+]

Interval training and Crataegus persica ameliorate diabetic nephropathy.Aug 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2022 Sep ;153:113411. Epub 2022 Jul 19. PMID: 36076481
Article Published Date : Aug 31, 2022
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Diabetes Mellitus: Type 1, Diabetic Nephropathy, Myocardial Ischemia
Therapeutic Actions : Exercise
Pharmacological Actions : Cardioprotective, MicroRNA modulator, Nrf2 activation
Additional Keywords : Plant Extracts
[+]

Investigation on the lipid-lowering effect and mechanism by combining turmeric with hawthorn in C57BL/6 obese mice.Jun 30, 2024

Pubmed Data : J Food Sci. 2024 Jul ;89(7):4493-4504. Epub 2024 May 28. PMID: 38804852
Article Published Date : Jun 30, 2024
Study Type : Animal Study
Additional Links
Substances : Hawthorn, Turmeric
Diseases : Obesity
Additional Keywords : Plant Extracts
[+]

Soluble dietary fiber of hawthorn relieves constipation induced by loperamide hydrochloride.Jul 14, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2024 Jul 15 ;13(14). Epub 2024 Jul 15. PMID: 39063304
Article Published Date : Jul 14, 2024
Study Type : Animal Study
Additional Links
Substances : Fiber, Hawthorn
Diseases : Constipation
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents
[+]

Structural characterization of a heteropolysaccharide from the fruit of Crataegus pinnatifida and its bioactivity on the gut microbiota of immunocompromised mice.Jun 30, 2023

Pubmed Data : Food Chem. 2023 Jul 1 ;413:135658. Epub 2023 Feb 9. PMID: 36780857
Article Published Date : Jun 30, 2023
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Pharmacological Actions : Immunomodulatory
Additional Keywords : Polysaccharides
[+]

The Crataegus azarolus berries aqueous extract significantly protected against diarrhea.Dec 14, 2020

Pubmed Data : Neurogastroenterol Motil. 2020 Dec 15:e14065. Epub 2020 Dec 15. PMID: 33320393
Article Published Date : Dec 14, 2020
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Diarrhea
Pharmacological Actions : Anti-Inflammatory Agents, Antidiarrheals, Antioxidants
Problem Substances : Hydrogenated Castor Oil
[+]

The effects of Crataegus pinnatifida and Wolfiporia extensa combination on diet-induced obesity.May 23, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2024 May 24 ;13(11). Epub 2024 May 24. PMID: 38890862
Article Published Date : May 23, 2024
Study Type : Animal Study
Additional Links
Substances : Hawthorn, Wolfiporia extensa
Diseases : Obesity
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Anti-Obesity Agents
[+]

The fruit of Crataegus pinnatifida ameliorates memory deficits in β-amyloid protein-induced Alzheimer's disease model.Jul 22, 2019

Pubmed Data : J Ethnopharmacol. 2019 Jul 23 ;243:112107. Epub 2019 Jul 23. PMID: 31349027
Article Published Date : Jul 22, 2019
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

The lipid-lowering effects of fenugreek gum, hawthorn pectin, and burdock inulin.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Nutr. 2023 ;10:1149094. Epub 2023 Mar 23. PMID: 37032784
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Burdock, Fenugreek, Hawthorn
Diseases : Hyperlipidemia
Pharmacological Actions : Gastrointestinal Agents, Hypolipidemic
[+]

The protective role of hawthorn fruit extract against high salt-induced hypertension.Feb 19, 2019

Pubmed Data : Food Funct. 2019 Feb 20 ;10(2):849-858. PMID: 30681096
Article Published Date : Feb 19, 2019
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Hypertension, Oxidative Stress
Pharmacological Actions : Antihypertensive Agents, Antioxidants
Additional Keywords : Plant Extracts
[+]

The results of this study demonstrate that hawthorn leaves and flowers are a promising treatment for hypercholesterolemia.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2012 ;12:105. Epub 2012 Jul 23. PMID: 22824306
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : High Cholesterol, Hypercholesterolemia
Pharmacological Actions : Anticholesteremic Agents
[+]

These findings suggest that hawthorn polyphenol extract can be used as the base ingredient for antiphotoaging food products.Jan 31, 2019

Pubmed Data : J Food Biochem. 2019 Feb ;43(2):e12708. Epub 2018 Nov 11. PMID: 31353662
Article Published Date : Jan 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Ultraviolet Radiation Induced Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Photoprotective
[+]

Total flavonoids of hawthorn leaves protect spinal motor neurons.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:925568. Epub 2022 Aug 22. PMID: 36071834
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Hawthorn
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

A new dineolignan with anti-β-amyloid aggregation activity from the fruits of crataegus pinnatifida bge.Aug 19, 2019

Pubmed Data : Nat Prod Res. 2019 Aug 20:1-4. Epub 2019 Aug 20. PMID: 31429298
Article Published Date : Aug 19, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

A review of the effects of Chinese hawthorn on metabolic syndrome.Apr 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2019 May ;22(5):460-468. PMID: 31217924
Article Published Date : Apr 30, 2019
Study Type : Review
Additional Links
Substances : Hawthorn
Diseases : Atherosclerosis, Dyslipidemias, Metabolic Syndrome X, Obesity
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic
[+]

A study on the treatment effects of Crataegus pinnatifida polysaccharide on non-alcoholic fatty liver.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Vet Sci. 2024 ;11:1383801. Epub 2024 Mar 27. PMID: 38601914
Article Published Date : Dec 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Gastrointestinal Agents, Hepatoprotective, Hypolipidemic
Additional Keywords : Polysaccharides
[+]

All data reviewed indicate that hawthorn is well tolerated, but more data are needed on concomitant use of hawthorn and other medications.Jan 01, 2006

Pubmed Data : Drug Saf. 2006 ;29(6):523-35. PMID: 16752934
Article Published Date : Jan 01, 2006
Study Type : Review
Additional Links
Substances : Hawthorn
Diseases : Heart Failure
Additional Keywords : Phytotherapy, Plant Extracts, Safety Study
[+]

Antioxidant activity of Crataegus aronia aqueous extract used in traditional Arab medicine in Israel.Oct 02, 2005

Pubmed Data : J Ethnopharmacol. 2005 Oct 3 ;101(1-3):153-61. PMID: 15970411
Article Published Date : Oct 02, 2005
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Antioxidant and anti-α-glucosidase activities of various solvent extracts and major bioactive components from the fruits of Crataegus pinnatifida.Feb 05, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2022 Feb 6 ;11(2). Epub 2022 Feb 6. PMID: 35204203
Article Published Date : Feb 05, 2022
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Diabetes: Oxidative Stress, Hyperglycemia
Pharmacological Actions : Alpha-glucosidase inhibitor , Antioxidants, Hypoglycemic Agents
[+]

Aqueous extract of Crataegus azarolus protects against DNA damage in human lymphoblast Cell K562 and enhances antioxidant activity.Jan 31, 2014

Pubmed Data : Appl Biochem Biotechnol. 2014 Feb ;172(4):2266-75. Epub 2013 Dec 19. PMID: 24347159
Article Published Date : Jan 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : DNA damage, Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Artificial intelligence-based application to explore inhibitors of neurodegenerative diseases.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurorobot. 2020 ;14:617327. Epub 2020 Dec 22. PMID: 33414713
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Brain Inflammation , Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
[+]

At therapeutic doses, hawthorn may cause a variety of side effects, but limited data suggest that it may be useful in the treatment of NYHA functional class II congestive heart failure.Mar 01, 2002

Pubmed Data : Am J Health Syst Pharm. 2002 Mar 1 ;59(5):417-22. PMID: 11887407
Article Published Date : Mar 01, 2002
Study Type : Review
Additional Links
Substances : Hawthorn
Diseases : Congestive Heart Failure, Congestive Heart Failure: NYHA functional class II
Pharmacological Actions : Cardioprotective
Additional Keywords : Phytotherapy
[+]

Characterization of procyanidin extracts from hawthorn (Crataegus pinnatifida) in human colorectal adenocarcinoma cell line.Feb 28, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Res Int. 2023 Mar ;165:112393. Epub 2022 Dec 28. PMID: 36869464
Article Published Date : Feb 28, 2023
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Prebiotics
Diseases : Colorectal Cancer
Pharmacological Actions : Chemopreventive, Gastrointestinal Agents
Additional Keywords : Proanthocyanidins
[+]

Chiral resolution and neuroprotective activities of enantiomeric 8-O-4' neolignans from the fruits of Crataegus pinnatifida Bge.May 05, 2019

Pubmed Data : Fitoterapia. 2019 May 6. Epub 2019 May 6. PMID: 31071436
Article Published Date : May 05, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Brain: Oxidative Stress, Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Neuroprotective Agents
[+]

Crataegus aronia has protective effects against high-fat diet-induced vascular inflammation.Jun 10, 2019

Pubmed Data : Cardiovasc Toxicol. 2019 Jun 11. Epub 2019 Jun 11. PMID: 31183600
Article Published Date : Jun 10, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : High Fat Diet, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hypolipidemic
[+]

Crataegus azarolus ethyl acetate extract-induced apoptosis in colorectal cancer.Apr 30, 2016

Pubmed Data : J Cell Biochem. 2016 May ;117(5):1262-72. Epub 2015 Nov 5. PMID: 26495895
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Colorectal Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Plant Extracts
[+]

Crataegus azarolus L. could be used for treating diseases related to oxidative stress, inflammatory reactions, and uncontrolled cell growth.Aug 02, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit Basic Res. 2017 Aug 3 ;23:270-284. Epub 2017 Aug 3. PMID: 28769026
Article Published Date : Aug 02, 2017
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Cancers: All, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiproliferative
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Crataegus azarolus var. eu- azarolus Maire has the efficiency to control hyperglycemia with its associated complications.Apr 17, 2017

Pubmed Data : BMC Complement Altern Med. 2017 Apr 18 ;17(1):218. Epub 2017 Apr 18. PMID: 28420354
Article Published Date : Apr 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Hawthorn
Diseases : Hyperglycemia
Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Hypolipidemic
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Crataegus extract WS1442 stimulates cardiomyogenesis and angiogenesis from stem cellsDec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:1357. Epub 2019 Nov 27. PMID: 31849643
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Myocardial Infarction
Pharmacological Actions : Angiogenesis Inducing Agents, Regenerative
Additional Keywords : Cardiac Stem Cells, Heart Regeneration, Plant Extracts
[+]

Crataegus laevigata suppresses LPS-induced oxidative stress during inflammatory response in human keratinocytes.Feb 05, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Feb 6 ;26(4). Epub 2021 Feb 6. PMID: 33562140
Article Published Date : Feb 05, 2021
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Development of a quantified herbal extract of hawthorn Crataegus mexicana leaves with vasodilator effect.Oct 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi Pharm J. 2021 Nov ;29(11):1258-1266. Epub 2021 Oct 19. PMID: 34819787
Article Published Date : Oct 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Cardiovascular Diseases, Hypertension
Pharmacological Actions : Vasodilator Agents
[+]

Dibenzofurans from Crataegus oresbia and their lipid-lowering activity.Feb 05, 2022

Pubmed Data : Nat Prod Res. 2022 Feb 6:1-7. Epub 2022 Feb 6. PMID: 35129009
Article Published Date : Feb 05, 2022
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Hyperlipidemia
Pharmacological Actions : Hypolipidemic
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Docking studies on potential mechanisms for decreasing insulin resistance by the tangzhiqing herbal formula.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:1057648. Epub 2020 Oct 9. PMID: 33133211
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Mulberry, Paeoniflorin, Peony, Rutin, Salvia miltiorrhiza
Diseases : Diabetes Mellitus: Type 2, Insulin Resistance
Pharmacological Actions : Insulin Sensitizers
[+]

Effect of Shan Zha (Hawthorn or Crataegus) on gastrointestinal cancer.Sep 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Pathog Ther. 2023 Oct ;1(4):229-237. Epub 2023 Feb 7. PMID: 38327605
Article Published Date : Sep 30, 2023
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Gastrointestinal Cancer
Pharmacological Actions : Chemotherapeutic
[+]

Exploring the mechanism of hawthorn leaves against coronary heart disease.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cardiovasc Med. 2022 ;9:804801. Epub 2022 Jun 16. PMID: 35783840
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Coronary Artery Disease, Heart Disease
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Extracts of Crataegus oxyacantha and Rosmarinus officinalis attenuate ischemic myocardial damage. Nov 13, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Nov 14 ;18(11). Epub 2017 Nov 14. PMID: 29135932
Article Published Date : Nov 13, 2017
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Rosemary
Diseases : Myocardial Ischemia
Pharmacological Actions : Cardioprotective, Vasodilator Agents
[+]

Gingko biloba, motherwort and hawthorn have antioxidant properties. Mar 01, 2006

Pubmed Data : Exp Oncol. 2006 Mar;28(1):30-5 PMID: 19702174
Article Published Date : Mar 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba, Hawthorn, Motherwort
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Hawthorn can be used as a new source for treating cardiovascular diseases.Jul 02, 2023

Pubmed Data : Food Funct. 2023 Jul 3 ;14(13):5870-5890. Epub 2023 Jul 3. PMID: 37337667
Article Published Date : Jul 02, 2023
Study Type : Review
Additional Links
Substances : Hawthorn
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective
Additional Keywords : Plant Extracts
[+]

Hawthorn extract may be used as an immunomodulator.Nov 18, 2019

Pubmed Data : Planta Med. 2019 Nov 19. Epub 2019 Nov 19. PMID: 31745939
Article Published Date : Nov 18, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Pharmacological Actions : Immunomodulatory
[+]

Hawthorn fruit extract protect against MC-LR-induced hepatotoxicity by attenuating oxidative stress and apoptosis.May 31, 2023

Pubmed Data : Environ Toxicol. 2023 Jun ;38(6):1239-1250. Epub 2023 Mar 7. PMID: 36880395
Article Published Date : May 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Chemically-Induced Liver Damage, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective
[+]

Hawthorn has radioprotective properties against gamma irradiation in mouse bone marrow cells.Jan 01, 2007

Pubmed Data : J Radiat Res (Tokyo). 2007 Jan;48(1):63-8. Epub 2006 Dec 22. PMID: 17185880
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Radiation Induced Illness, Radiation Induced Illness: Bone Marrow
Pharmacological Actions : Radioprotective
Additional Keywords : Plant Extracts
[+]

Hawthorn polyphenols reduce high glucose-induced inflammation and apoptosis in ARPE-19 cells.Jan 31, 2021

Pubmed Data : J Food Biochem. 2021 Feb ;45(2):e13623. Epub 2021 Jan 24. PMID: 33491221
Article Published Date : Jan 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Polyphenols
Diseases : Diabetic Retinopathy, Hyperglycemia
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants
[+]

Hawthorn, onion and garlic may dissolve hydroxapatite crystals associated with arteriosclerosis. Jan 01, 2003

Pubmed Data : Folia Med Cracov. 2003;44(1-2):187-99. PMID: 15232901
Article Published Date : Jan 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Garlic, Hawthorn, Onion
Diseases : Arterial Calcification, Arteriosclerosis
Additional Keywords : Decalcification
[+]

In this review authors present current state of knowledge about possible beneficial effects of WS 1442 special extract on cardiovascular system.Jul 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Physiol Pharmacol. 2017 Aug ;68(4):521-526. PMID: 29151068
Article Published Date : Jul 31, 2017
Study Type : Review
Additional Links
Substances : Hawthorn
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective, Vasodilator Agents
Additional Keywords : Plant Extracts
[+]

Insight into isolation and characterization of phenolic compounds from hawthorn.Aug 18, 2022

Pubmed Data : Plant Foods Hum Nutr. 2022 Aug 19. Epub 2022 Aug 19. PMID: 35986175
Article Published Date : Aug 18, 2022
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Neurodegenerative Diseases, Oxidative Stress
Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Neuroprotective Agents
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Lignans from the seeds of Chinese hawthorn against β-amyloid aggregation.Jun 30, 2018

Pubmed Data : Nat Prod Res. 2018 Jul ;32(14):1706-1713. Epub 2017 Nov 8. PMID: 29115158
Article Published Date : Jun 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Lignans
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Lignans with neuroprotective activity from the fruits of Crataegus pinnatifida.May 11, 2022

Pubmed Data : Fitoterapia. 2022 May 12:105216. Epub 2022 May 12. PMID: 35569638
Article Published Date : May 11, 2022
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Lignans
Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress
Pharmacological Actions : Neuroprotective Agents
[+]

Major triterpenoids in Chinese hawthorn inhibited proliferation and induced apoptosis in MDA-MB-231 cancer cells.Jan 31, 2017

Pubmed Data : Food Chem Toxicol. 2017 Feb ;100:149-160. Epub 2016 Dec 23. PMID: 28025124
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Ursolic Acid
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, Cyclin D1 Down-Regulation
Additional Keywords : Antiproliferative, Breast Cancer: Triple Negative, Dose Response, Hawthorn, Ursolic Acid
[+]

Mexican hawthorn stems and leaves induce cell death on breast cancer cells.Oct 21, 2019

Pubmed Data : Nutr Cancer. 2019 Oct 22:1-11. Epub 2019 Oct 22. PMID: 31635496
Article Published Date : Oct 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
[+]

Neuroprotective effects of hawthorn leaf flavonoids in Aβ25-35 -induced Alzheimer's disease model.Nov 28, 2022

Pubmed Data : Phytother Res. 2022 Nov 29. Epub 2022 Nov 29. PMID: 36447359
Article Published Date : Nov 28, 2022
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Hawthorn
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

New constituents from the low polar fraction of the fruits of Crataegus dahurica and their anti-inflammatory activity in RAW264.7 cells.Jan 31, 2020

Pubmed Data : Chem Biodivers. 2020 Feb ;17(2):e1900609. Epub 2020 Jan 29. PMID: 31916412
Article Published Date : Jan 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Pectin oligosaccharides from hawthorn inhibit the formation of advanced glycation end products in infant formula milk powder.Dec 10, 2019

Pubmed Data : Food Funct. 2019 Dec 11 ;10(12):8081-8093. PMID: 31735943
Article Published Date : Dec 10, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Oligosaccharides
Diseases : Advanced Glycation End products (AGE)
Pharmacological Actions : Anti-Glycation Agents
Problem Substances : Infant Formula
[+]

Phenolic compounds from the leaves of Crataegus pinnatifida Bge. var. major N.E.Br. And their lipid-lowering effects.Aug 31, 2021

Pubmed Data : Bioorg Med Chem Lett. 2021 Sep 1 ;47:128211. Epub 2021 Jun 19. PMID: 34157392
Article Published Date : Aug 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Hyperlipidemia
Pharmacological Actions : Hypolipidemic
[+]

Phenylpropanoids from the fruit of Crataegus pinnatifida exhibit cytotoxicity on hepatic carcinoma cells through apoptosis induction.May 31, 2018

Pubmed Data : Fitoterapia. 2018 Jun ;127:301-307. Epub 2018 Mar 11. PMID: 29534982
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic
[+]

Polyphenol contents and antioxidant activities of extracts from flowers of two Crataegus azarolus L. varieties.Apr 30, 2009

Pubmed Data : Pak J Biol Sci. 2009 May 1 ;12(9):660-8. PMID: 19634468
Article Published Date : Apr 30, 2009
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Hawthorn, Polyphenols
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Polyphenolic compounds of Crataegus berry, leaf, and flower extracts affect viability and invasive potential of human glioblastoma cells.Apr 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 May 1 ;26(9). Epub 2021 May 1. PMID: 34062758
Article Published Date : Apr 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Polyphenols
Diseases : Glioblastoma
Pharmacological Actions : Apoptotic
[+]

Polyphenolic-polysaccharide conjugates from flowers and fruits of hawthorn have anticoagulant activity.Aug 31, 2018

Pubmed Data : Int J Biol Macromol. 2018 Sep ;116:869-879. Epub 2018 May 17. PMID: 29777813
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Polyphenols
Pharmacological Actions : Anticoagulants
Additional Keywords : Plant Extracts
[+]

Potential roles and key mechanisms of hawthorn extract against various liver diseases.Feb 17, 2022

Pubmed Data : Nutrients. 2022 Feb 18 ;14(4). Epub 2022 Feb 18. PMID: 35215517
Article Published Date : Feb 17, 2022
Study Type : Review
Additional Links
Substances : Hawthorn
Diseases : Alcoholic Liver Disease, High Cholesterol, Liver Cancer, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Apoptotic, Hypolipidemic
Additional Keywords : Plant Extracts
[+]

Procyanidins from hawthorn alleviate lipid metabolism disorder via inhibiting insulin resistance and oxidative stress, normalizing the gut microbiota structure.Jul 17, 2022

Pubmed Data : Food Funct. 2022 Jul 18 ;13(14):7901-7917. Epub 2022 Jul 18. PMID: 35781311
Article Published Date : Jul 17, 2022
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Gaucher Disease, Inflammation, Insulin Resistance, Lipid Metabolism: Abnormalities, Oxidative Stress, Tay-Sachs Disease
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Hypolipidemic, NF-kappaB Inhibitor
Additional Keywords : Procyanidins
[+]

Protective effect of hawthorn fruit extract against high fructose-induced oxidative stress and endoplasmic reticulum stress in pancreatic β-cells.Mar 07, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2023 Mar 8 ;12(6). Epub 2023 Mar 8. PMID: 36981057
Article Published Date : Mar 07, 2023
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : High Fructose Diet
Pharmacological Actions : Antioxidants, Pancreato Protective Agents
[+]

Protective effect of hawthorn vitexin on the ethanol-injured DNA of BRL-3A hepatocytes.Dec 16, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicine (Baltimore). 2021 Dec 17 ;100(50):e28228. PMID: 34918685
Article Published Date : Dec 16, 2021
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Vitexins
Diseases : Alcohol Toxicity , DNA damage, Liver Damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

Scientific evidence shows that WS 1442 is safe and has a beneficial effect in patients with heart failure.Jan 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Cardiovasc Drugs. 2018 Feb ;18(1):25-36. PMID: 29080984
Article Published Date : Jan 31, 2018
Study Type : Review
Additional Links
Substances : Flavonoids, Hawthorn
Diseases : Heart Failure
Pharmacological Actions : Cardioprotective
Additional Keywords : Phytotherapy, Plant Extracts
[+]

The results suggested that C. aronia L. could be used as a potential treatment against human lung cancer.Sep 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2020 Oct 1 ;21(10):2993-3003. Epub 2020 Oct 1. PMID: 33112559
Article Published Date : Sep 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Lung Cancer
Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Therapeutic effects of Crataegus monogyna inhibitors against breast cancer.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2023 ;14:1187079. Epub 2023 Apr 27. PMID: 37180727
Article Published Date : Dec 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Breast Cancer
Pharmacological Actions : Chemopreventive
[+]

These findings highlight the untapped potential of C. monogyna for further exploration in treating liver damage, inflammation, and leukemia.Jun 14, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2024 Jun 15 ;17(6). Epub 2024 Jun 15. PMID: 38931453
Article Published Date : Jun 14, 2024
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Liver Cancer, Promyelocytic leukemia
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
[+]

These findings suggest that C. azarolus should be explored as a novel potential immunomodulatory agent for the treatment of inflammatory diseases.May 31, 2016

Pubmed Data : Tumour Biol. 2016 Jun ;37(6):7967-80. Epub 2015 Dec 28. PMID: 26711781
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Immunomodulatory
Additional Keywords : Plant Extracts
[+]

Total Flavonoid extract from hawthorn improves inflammatory cytokines-evoked epithelial barrier deficit.Feb 16, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2020 Feb 17 ;26:e920170. Epub 2020 Feb 17. PMID: 32065826
Article Published Date : Feb 16, 2020
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Copyright: marilyna / 123RF Stock Photo

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