Hawthorn

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62 Diseases Researched for Hawthorn
NameACCKFocus
Heart Failure744Locked
Congestive Heart Failure321Locked
Diabetes Mellitus: Type 2517Locked
Oxidative Stress914Locked
DNA damage211Locked
Inflammation811Locked
Lipid Peroxidation211Locked
Radiation Induced Illness211Locked
C-Reactive Protein110Locked
Coronary Artery Disease110Locked
Left Ventricular Dysfunction110Locked
Nonalcoholic fatty liver disease (NAFLD)36Locked
Alzheimer's Disease34Locked
Chemotherapy-Induced Toxicity: Doxorubicin24Locked
Hypercholesterolemia24Locked
Hyperlipidemia24Locked
Hypertension24Locked
Ultraviolet Radiation Induced Damage24Locked
Arteriosclerosis23Locked
Atherosclerosis23Locked
Dyslipidemias23Locked
Myocardial Ischemia23Locked
Obesity23Locked
Aging Skin12Locked
Alcoholic Liver Disease12Locked
Arrhythmias: Cardiac12Locked
Cholesterol: Oxidation12Locked
Depression12Locked
Diabetes Mellitus: Type 112Locked
Diabetes Mellitus: Type 2: Prevention12Locked
Diabetes: Cognitive Dysfunction12Locked
Diabetic Complications12Locked
Diabetic Nephropathy12Locked
Diarrhea12Locked
Gastric Ulcer12Locked
Gram-Positive Bacterial Infections12Locked
High Cholesterol12Locked
High Fructose Diet12Locked
Hyperglycemia22Locked
Metabolic Diseases12Locked
Pesticide Toxicity 12Locked
Advanced Glycation End products (AGE)11Locked
Arterial Calcification11Locked
Brain Inflammation 11Locked
Brain: Oxidative Stress11Locked
Breast Cancer11Locked
Breast Cancer: Triple Negative 11Locked
Cancers: All11Locked
Cardiovascular Diseases11Locked
Colorectal Cancer11Locked
Congestive Heart Failure: NYHA functional class II11Locked
Diabetic Retinopathy11Locked
High Fat Diet11Locked
Hydrogen Peroxide Induced Toxicity11Locked
Insulin Resistance11Locked
Lipopolysaccharide-Induced Toxicity11Locked
Liver Cancer11Locked
Lung Cancer11Locked
Metabolic Syndrome X11Locked
Myocardial Infarction11Locked
Neurodegenerative Diseases11Locked
Radiation Induced Illness: Bone Marrow11Locked
45 Pharmacological Actions Researched for Hawthorn
NameACCKFocus
Antioxidants2743Locked
Hypolipidemic1025Locked
Anti-Inflammatory Agents1523Locked
Hepatoprotective714Locked
Radioprotective211Locked
Neuroprotective Agents710Locked
Cardioprotective68Locked
Hypoglycemic Agents58Locked
Apoptotic55Locked
Interleukin-6 Downregulation35Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor35Locked
Anticholesteremic Agents24Locked
Antihypertensive Agents24Locked
Antiproliferative 44Locked
Chemoprotective Agents24Locked
Photoprotective24Locked
Interleukin-1 beta downregulation23Locked
Anti-atherogenic12Locked
Antidepressive Agents12Locked
Antidiarrheals12Locked
Enzyme Inhibitors12Locked
Heme oxygenase-1 up-regulation12Locked
Immunomodulatory22Locked
Interleukin-1 alpha downregulation12Locked
Matrix metalloproteinase-1 (MMP-1) inhibitor12Locked
NF-kappaB Inhibitor12Locked
Nrf2 activation12Locked
Renoprotective12Locked
SIRT1 Activator12Locked
Superoxide Dismutase Up-regulation12Locked
Vasodilator Agents22Locked
Wnt/β-catenin signaling pathway modulation12Locked
Angiogenesis Inducing Agents11Locked
Anti-Apoptotic11Locked
Anti-Glycation Agents11Locked
Anticoagulants11Locked
Antineoplastic Agents11Locked
Caspase-3 Activation11Locked
Caspase-9 Activation11Locked
Cell cycle arrest11Locked
Chemosensitizer11Locked
Cyclin D1 Down-Regulation11Locked
Insulin Sensitizers11Locked
Interleukin-8 downregulation11Locked
Regenerative11Locked

View the Evidence:
78 Abstracts with Hawthorn Research

[+]

C. laevigata decreased neutrophil elastase and showed a trend to lower LDL-C.Jun 14, 2011

Pubmed Data : Phytomedicine. 2011 Jun 15 ;18(8-9):769-75. Epub 2011 Jan 15. PMID: 21242072
Article Published Date : Jun 14, 2011
Study Type : Human Study
Additional Links
Substances : Hawthorn
Diseases : C-Reactive Protein, Coronary Artery Disease, Diabetes Mellitus: Type 2, Lipid Peroxidation
Pharmacological Actions : Hypolipidemic
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Hawthorn (Crataegus) reduces the incidence of sudden cardiac death in patients with less compromised left ventricular function.Dec 01, 2008

Pubmed Data : Eur J Heart Fail. 2008 Dec;10(12):1255-63. Epub 2008 Nov 18. PMID: 19019730
Article Published Date : Dec 01, 2008
Study Type : Human Study
Additional Links
Substances : Hawthorn
Diseases : Heart Failure, Left Ventricular Dysfunction
Additional Keywords : Plant Extracts, Risk Reduction
[+]

Hawthorn berry extract is safe and effective in improving exercise tolerance and quality of life in patients with congestive heart failure Oct 01, 2001

Pubmed Data : Arzneimittelforschung. 2001 Oct;51(10):793-8. PMID: 11715631
Article Published Date : Oct 01, 2001
Study Type : Human Study
Additional Links
Substances : Hawthorn
Diseases : Congestive Heart Failure, Heart Failure
[+]

Hawthorn berry improves symptoms in patients with congestive heart failure. Sep 26, 2007

Pubmed Data : JAMA. 2007 Sep 26;298(12):1420-8. PMID: 12833999
Article Published Date : Sep 26, 2007
Study Type : Human Study
Additional Links
Substances : Hawthorn
Diseases : Congestive Heart Failure
[+]

Hawthorn protects against gamma radiation induced genotoxicity in human blood lymphocytes.Feb 01, 2009

Pubmed Data : Radiat Environ Biophys. 2009 Feb;48(1):95-8. Epub 2008 Sep 4. PMID: 18769933
Article Published Date : Feb 01, 2009
Study Type : Human Study
Additional Links
Substances : Hawthorn
Diseases : DNA damage, Radiation Induced Illness
Pharmacological Actions : Radioprotective
Additional Keywords : Plant Extracts
[+]

Hawthorn provides benefits as an adjunctive treatment for chronic heart failure. - Article 1Jun 01, 2003

Pubmed Data : Am J Med. 2003 Jun 1;114(8):665-74. PMID: 12798455
Article Published Date : Jun 01, 2003
Study Type : Human Study
Additional Links
Substances : Hawthorn
Diseases : Heart Failure
[+]

Hawthorn provides benefits as an adjunctive treatment for chronic heart failure. - Article 2Jan 23, 2008

Pubmed Data : Cochrane Database Syst Rev. 2008 Jan 23;(1):CD005312. PMID: 18254076
Article Published Date : Jan 23, 2008
Study Type : Human Study
Additional Links
Substances : Hawthorn
Diseases : Heart Failure
[+]

A herbal complex is an effective herbal formulation in the attenuation of obesity and obesity-induced metabolic dysfunction including NAFLD.Jan 07, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Jan 8 ;26(2). Epub 2021 Jan 8. PMID: 33435558
Article Published Date : Jan 07, 2021
Study Type : Animal Study
Additional Links
Substances : Cinnamon, Hawthorn, Raspberry
Diseases : Metabolic Diseases, Nonalcoholic fatty liver disease (NAFLD), Obesity
Pharmacological Actions : Enzyme Inhibitors, Hepatoprotective, Hypolipidemic
[+]

A phenol-rich fraction of hawthorn fruit exhibited satisfactory hypolipidemic and antioxidant effects.Sep 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Mag. 2017 Oct-Dec;13(52):725-731. Epub 2017 Nov 13. PMID: 29200740
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Hyperlipidemia
Pharmacological Actions : Antioxidants, Hypolipidemic
[+]

Antihypertensive effects of hydroalcoholic extract of Crataegus Azarolus subspecies Aronia fruit in rats with renovascular hypertension.Apr 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Med Sci. 2017 May ;42(3):266-274. PMID: 28533575
Article Published Date : Apr 30, 2017
Study Type : Animal Study
Additional Links
Substances : Chokeberry, Hawthorn
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
[+]

Astragalus polysaccharides combined with Crataegus flavonoids may facilitate the treatment of type 1 or 2 diabetes.Apr 14, 2016

Pubmed Data : Mol Med Rep. 2016 Apr 15. Epub 2016 Apr 15. PMID: 27081750
Article Published Date : Apr 14, 2016
Study Type : Animal Study
Additional Links
Substances : Astragalus, Hawthorn
Diseases : Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 2
Pharmacological Actions : Anti-Inflammatory Agents, Hypoglycemic Agents
Additional Keywords : Natural Substance Synergy
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Beneficial effects of crataegus oxyacantha extract on neurobehavioral deficits and brain tissue damages induced by an insecticide mixtures.May 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jun ;114:108795. Epub 2019 Mar 22. PMID: 30909143
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Pesticide Toxicity
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Chlorpyrifos, Deltamethrin
[+]

C. aronia exhibits therapeutic and protective effects on NAFLD in an animal model.Jul 15, 2016

Pubmed Data : Arch Physiol Biochem. 2016 Jul 16:1-8. Epub 2016 Jul 16. PMID: 27424611
Article Published Date : Jul 15, 2016
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Antioxidants, Hepatoprotective, Hypolipidemic
Additional Keywords : Risk Reduction
[+]

C. aronia inhibits high fat diet-induced vascular inflammation.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2019 Dec ;57(1):38-48. PMID: 30702358
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Cholesterol: Oxidation, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

C. oxyacantha has both a therapeutic and a protective effect for NAFLD.May 01, 2018

Pubmed Data : Drug Res (Stuttg). 2018 May 2. Epub 2018 May 2. PMID: 29719880
Article Published Date : May 01, 2018
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Antioxidants, Hepatoprotective
[+]

Cardioprotective effect of resistance training and Crataegus oxyacantha extract on ischemia reperfusion-induced oxidative stress in diabetic rats.Mar 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Apr ;100:455-460. Epub 2018 Feb 22. PMID: 29477090
Article Published Date : Mar 31, 2018
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Diabetic Complications, Myocardial Ischemia
Therapeutic Actions : Exercise: Resistance Training
Pharmacological Actions : Antioxidants, Cardioprotective
Additional Keywords : Plant Extracts
[+]

Chemical basis of hawthorn processed with honey protecting against myocardial ischaemia.Mar 31, 2020

Pubmed Data : Food Funct. 2020 Apr 1 ;11(4):3134-3143. Epub 2020 Mar 24. PMID: 32207479
Article Published Date : Mar 31, 2020
Study Type : Animal Study
Additional Links
Substances : Hawthorn, Honey
Diseases : Myocardial Ischemia
Pharmacological Actions : Cardioprotective
Additional Keywords : Plant Extracts
[+]

Chinese hawthorn fruit reduces inflammation and oxidative stress in rats with doxorubicin-Induced chronic heart failure.Nov 23, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2020 Nov 24 ;26:e926654. Epub 2020 Nov 24. PMID: 33232307
Article Published Date : Nov 23, 2020
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Chemoprotective Agents, Interleukin-1 beta downregulation
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Chlorogenic acid and Crataegus pinnatifida extracts prevented depressive behaviour and thereby have potential as natural antidepressants.Jun 11, 2018

Pubmed Data : Mol Nutr Food Res. 2018 Jun 12:e1800029. Epub 2018 Jun 12. PMID: 29893510
Article Published Date : Jun 11, 2018
Study Type : Animal Study
Additional Links
Substances : Chlorogenic Acid, Hawthorn
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
[+]

Crataegus pinnatifida Bunge could be a potential alternative medicine for bone diseases.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:5521562. Epub 2021 Mar 27. PMID: 33859705
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
[+]

Crataegus pinnatifida polysaccharide alleviates colitis via modulation of gut microbiota and SCFAs metabolism.Mar 23, 2021

Pubmed Data : Int J Biol Macromol. 2021 Mar 24 ;181:357-368. Epub 2021 Mar 24. PMID: 33774071
Article Published Date : Mar 23, 2021
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : IBRO Rep. 2019 Dec ;7:90-96. Epub 2019 Oct 22. PMID: 31720488
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Diabetes: Cognitive Dysfunction
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic, Neuroprotective Agents
[+]

Hawthorn and kiwi fruit extracts are superior to simvastatin in lowering cholesterol in mice fed a high cholesterol diet.Jan 01, 2009

Pubmed Data : Am J Chin Med. 2009;37(5):903-8. PMID: 19885950
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Hawthorn, Kiwifruit
Diseases : Arteriosclerosis, Hyperlipidemia
Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic
Additional Keywords : Plant Extracts, Superiority of Natural Substances versus Drugs
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Hawthorn and Rosemary treatments have different mechanisms of action; however they show hepatoprotective effect against alcoholic liver disease.Jun 30, 2019

Pubmed Data : Altern Ther Health Med. 2019 Jul ;25(4):54-63. PMID: 31202212
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Hawthorn, Rosemary
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
[+]

Hawthorn demonstrates a modest beneficial effects on cardiac remodeling and function during long-term, pressure overload-induced heart failure in rats.Jun 01, 2009

Pubmed Data : Pharmacotherapy. 2009 Jun;29(6):639-48. PMID: 19476417
Article Published Date : Jun 01, 2009
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Heart Failure
Additional Keywords : Plant Extracts
[+]

Hawthorn extract could have protective effects in ovariectomized rats.May 12, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2016 May 13 ;8(5). Epub 2016 May 13. PMID: 27187458
Article Published Date : May 12, 2016
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Ovariectomy-Induced Changes, Plant Extracts
[+]

Hawthorn extract represents a useful agent for the prevention or treatment of T2DM.Mar 22, 2017

Pubmed Data : J Sci Food Agric. 2017 Mar 23. Epub 2017 Mar 23. PMID: 28337770
Article Published Date : Mar 22, 2017
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Diabetes Mellitus: Type 2, Diabetes Mellitus: Type 2: Prevention
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Diabetes mellitus: Type 2, Diabetes Mellitus: Type 2: Prevention, Hawthorn, Hypoglycemic Agents
[+]

Hawthorn extracts are able to protect from hypercholesterolemia-induced oxidative stress and hepatic injuries.Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2015 Jul ;18(7):691-9. PMID: 26361538
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Hypercholesterolemia, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
[+]

Hawthorn flower extract has hypotensive and potential antiarrhtymic action. Apr 01, 2005

Pubmed Data : Helicobacter. 2005 Apr;10(2):139-45. PMID: 10960896
Article Published Date : Apr 01, 2005
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Arrhythmias: Cardiac
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Hawthorn fruit, especially its peel, is an excellent source of natural chemopreventive agents in the treatment of liver disorders.Aug 12, 2016

Pubmed Data : Chem Biol Interact. 2016 Aug 13. Epub 2016 Aug 13. PMID: 27531227
Article Published Date : Aug 12, 2016
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Dyslipidemias, High Fructose Diet, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Hawthorn has anti-inflammatory, gastroprotective, free-radical-scavenging, and antimicrobial activities. Sep 10, 2008

Pubmed Data : J Agric Food Chem. 2008 Sep 10;56(17):7700-9. Epub 2008 Aug 13. PMID: 18698794
Article Published Date : Sep 10, 2008
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Gastric Ulcer, Gram-Positive Bacterial Infections, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Drug: Ranitidine, Histamine H2-Receptor Antagonist Alternatives, Natural Substances Versus Drugs, Plant Extracts
[+]

Hawthorn herbal preparation from Crataegus oxyacantha attenuates carbon tetrachloride-induced hepatic fibrosis.Nov 23, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Nov 24 ;9(12). Epub 2020 Nov 24. PMID: 33255507
Article Published Date : Nov 23, 2020
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Hawthorn leave flavonoids can slow down the development of atherosclerosis in apoE knockout mice.Feb 22, 2017

Pubmed Data : J Ethnopharmacol. 2017 Feb 23 ;198:479-488. Epub 2017 Jan 21. PMID: 28119096
Article Published Date : Feb 22, 2017
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Atherosclerosis
Pharmacological Actions : Anti-atherogenic
Additional Keywords : Anti-atherogenic, Atherosclerosis, Hawthorn
[+]

Hawthorn polyphenol extract could be used as a functional food component in the adjuvant treatment of T2D.Mar 31, 2021

Pubmed Data : Food Res Int. 2021 Apr ;142:110239. Epub 2021 Feb 25. PMID: 33773689
Article Published Date : Mar 31, 2021
Study Type : Animal Study
Additional Links
Substances : Hawthorn, Polyphenols
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic, Interleukin-6 Downregulation, NF-kappaB Inhibitor, SIRT1 Activator, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Wnt/β-catenin signaling pathway modulation
[+]

Hawthorn polyphenol extract inhibits UVB-induced skin photoaging.Aug 14, 2018

Pubmed Data : J Agric Food Chem. 2018 Aug 15 ;66(32):8537-8546. Epub 2018 Jul 31. PMID: 30032605
Article Published Date : Aug 14, 2018
Study Type : Animal Study
Additional Links
Substances : Hawthorn, Polyphenols
Diseases : Aging Skin, Ultraviolet Radiation Induced Damage
Therapeutic Actions : Sunlight exposure
Pharmacological Actions : Matrix metalloproteinase-1 (MMP-1) inhibitor, Photoprotective
Additional Keywords : Plant Extracts
[+]

Hawthorne leaf flavonoids prevent oxidative stress injury of renal tissues in rats with diabetic kidney disease.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Pathol. 2019 ;12(9):3440-3446. Epub 2019 Sep 1. PMID: 31934188
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Diabetic Nephropathy
Pharmacological Actions : Antioxidants, Renoprotective
[+]

Hepatoprotective effects of Algerian Crataegus oxyacantha leaves.Jul 28, 2018

Pubmed Data : Recent Pat Food Nutr Agric. 2018 Jul 29. Epub 2018 Jul 29. PMID: 30058501
Article Published Date : Jul 28, 2018
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Hepatoprotective
[+]

The Crataegus azarolus berries aqueous extract significantly protected against diarrhea.Dec 14, 2020

Pubmed Data : Neurogastroenterol Motil. 2020 Dec 15:e14065. Epub 2020 Dec 15. PMID: 33320393
Article Published Date : Dec 14, 2020
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Diarrhea
Pharmacological Actions : Anti-Inflammatory Agents, Antidiarrheals, Antioxidants
Problem Substances : Hydrogenated Castor Oil
[+]

The fruit of Crataegus pinnatifida ameliorates memory deficits in β-amyloid protein-induced Alzheimer's disease model.Jul 22, 2019

Pubmed Data : J Ethnopharmacol. 2019 Jul 23 ;243:112107. Epub 2019 Jul 23. PMID: 31349027
Article Published Date : Jul 22, 2019
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

The protective role of hawthorn fruit extract against high salt-induced hypertension.Feb 19, 2019

Pubmed Data : Food Funct. 2019 Feb 20 ;10(2):849-858. PMID: 30681096
Article Published Date : Feb 19, 2019
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Hypertension, Oxidative Stress
Pharmacological Actions : Antihypertensive Agents, Antioxidants
Additional Keywords : Plant Extracts
[+]

The results of this study demonstrate that hawthorn leaves and flowers are a promising treatment for hypercholesterolemia.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2012 ;12:105. Epub 2012 Jul 23. PMID: 22824306
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : High Cholesterol, Hypercholesterolemia
Pharmacological Actions : Anticholesteremic Agents
[+]

These findings suggest that hawthorn polyphenol extract can be used as the base ingredient for antiphotoaging food products.Jan 31, 2019

Pubmed Data : J Food Biochem. 2019 Feb ;43(2):e12708. Epub 2018 Nov 11. PMID: 31353662
Article Published Date : Jan 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Ultraviolet Radiation Induced Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Photoprotective
[+]

A new dineolignan with anti-β-amyloid aggregation activity from the fruits of crataegus pinnatifida bge.Aug 19, 2019

Pubmed Data : Nat Prod Res. 2019 Aug 20:1-4. Epub 2019 Aug 20. PMID: 31429298
Article Published Date : Aug 19, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

A review of the effects of Chinese hawthorn on metabolic syndrome.Apr 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2019 May ;22(5):460-468. PMID: 31217924
Article Published Date : Apr 30, 2019
Study Type : Review
Additional Links
Substances : Hawthorn
Diseases : Atherosclerosis, Dyslipidemias, Metabolic Syndrome X, Obesity
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic
[+]

All data reviewed indicate that hawthorn is well tolerated, but more data are needed on concomitant use of hawthorn and other medications.Jan 01, 2006

Pubmed Data : Drug Saf. 2006 ;29(6):523-35. PMID: 16752934
Article Published Date : Jan 01, 2006
Study Type : Review
Additional Links
Substances : Hawthorn
Diseases : Heart Failure
Additional Keywords : Phytotherapy, Plant Extracts, Safety Study
[+]

Antioxidant activity of Crataegus aronia aqueous extract used in traditional Arab medicine in Israel.Oct 02, 2005

Pubmed Data : J Ethnopharmacol. 2005 Oct 3 ;101(1-3):153-61. PMID: 15970411
Article Published Date : Oct 02, 2005
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Aqueous extract of Crataegus azarolus protects against DNA damage in human lymphoblast Cell K562 and enhances antioxidant activity.Jan 31, 2014

Pubmed Data : Appl Biochem Biotechnol. 2014 Feb ;172(4):2266-75. Epub 2013 Dec 19. PMID: 24347159
Article Published Date : Jan 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : DNA damage, Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Artificial intelligence-based application to explore inhibitors of neurodegenerative diseases.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurorobot. 2020 ;14:617327. Epub 2020 Dec 22. PMID: 33414713
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Brain Inflammation , Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
[+]

At therapeutic doses, hawthorn may cause a variety of side effects, but limited data suggest that it may be useful in the treatment of NYHA functional class II congestive heart failure.Mar 01, 2002

Pubmed Data : Am J Health Syst Pharm. 2002 Mar 1 ;59(5):417-22. PMID: 11887407
Article Published Date : Mar 01, 2002
Study Type : Review
Additional Links
Substances : Hawthorn
Diseases : Congestive Heart Failure, Congestive Heart Failure: NYHA functional class II
Pharmacological Actions : Cardioprotective
Additional Keywords : Phytotherapy
[+]

Chiral resolution and neuroprotective activities of enantiomeric 8-O-4' neolignans from the fruits of Crataegus pinnatifida Bge.May 05, 2019

Pubmed Data : Fitoterapia. 2019 May 6. Epub 2019 May 6. PMID: 31071436
Article Published Date : May 05, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Brain: Oxidative Stress, Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Neuroprotective Agents
[+]

Crataegus aronia has protective effects against high-fat diet-induced vascular inflammation.Jun 10, 2019

Pubmed Data : Cardiovasc Toxicol. 2019 Jun 11. Epub 2019 Jun 11. PMID: 31183600
Article Published Date : Jun 10, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : High Fat Diet, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hypolipidemic
[+]

Crataegus azarolus ethyl acetate extract-induced apoptosis in colorectal cancer.Apr 30, 2016

Pubmed Data : J Cell Biochem. 2016 May ;117(5):1262-72. Epub 2015 Nov 5. PMID: 26495895
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Colorectal Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Plant Extracts
[+]

Crataegus azarolus L. could be used for treating diseases related to oxidative stress, inflammatory reactions, and uncontrolled cell growth.Aug 02, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit Basic Res. 2017 Aug 3 ;23:270-284. Epub 2017 Aug 3. PMID: 28769026
Article Published Date : Aug 02, 2017
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Cancers: All, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiproliferative
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Crataegus azarolus var. eu- azarolus Maire has the efficiency to control hyperglycemia with its associated complications.Apr 17, 2017

Pubmed Data : BMC Complement Altern Med. 2017 Apr 18 ;17(1):218. Epub 2017 Apr 18. PMID: 28420354
Article Published Date : Apr 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Hawthorn
Diseases : Hyperglycemia
Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Hypolipidemic
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Crataegus extract WS1442 stimulates cardiomyogenesis and angiogenesis from stem cellsDec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:1357. Epub 2019 Nov 27. PMID: 31849643
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Myocardial Infarction
Pharmacological Actions : Angiogenesis Inducing Agents, Regenerative
Additional Keywords : Cardiac Stem Cells, Heart Regeneration, Plant Extracts
[+]

Crataegus laevigata suppresses LPS-induced oxidative stress during inflammatory response in human keratinocytes.Feb 05, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Feb 6 ;26(4). Epub 2021 Feb 6. PMID: 33562140
Article Published Date : Feb 05, 2021
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Docking studies on potential mechanisms for decreasing insulin resistance by the tangzhiqing herbal formula.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:1057648. Epub 2020 Oct 9. PMID: 33133211
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Mulberry, Paeoniflorin, Peony, Rutin, Salvia miltiorrhiza
Diseases : Diabetes Mellitus: Type 2, Insulin Resistance
Pharmacological Actions : Insulin Sensitizers
[+]

Extracts of Crataegus oxyacantha and Rosmarinus officinalis attenuate ischemic myocardial damage. Nov 13, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Nov 14 ;18(11). Epub 2017 Nov 14. PMID: 29135932
Article Published Date : Nov 13, 2017
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Rosemary
Diseases : Myocardial Ischemia
Pharmacological Actions : Cardioprotective, Vasodilator Agents
[+]

Gingko biloba, motherwort and hawthorn have antioxidant properties. Mar 01, 2006

Pubmed Data : Exp Oncol. 2006 Mar;28(1):30-5 PMID: 19702174
Article Published Date : Mar 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba, Hawthorn, Motherwort
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Hawthorn extract may be used as an immunomodulator.Nov 18, 2019

Pubmed Data : Planta Med. 2019 Nov 19. Epub 2019 Nov 19. PMID: 31745939
Article Published Date : Nov 18, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Pharmacological Actions : Immunomodulatory
[+]

Hawthorn has radioprotective properties against gamma irradiation in mouse bone marrow cells.Jan 01, 2007

Pubmed Data : J Radiat Res (Tokyo). 2007 Jan;48(1):63-8. Epub 2006 Dec 22. PMID: 17185880
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Radiation Induced Illness, Radiation Induced Illness: Bone Marrow
Pharmacological Actions : Radioprotective
Additional Keywords : Plant Extracts
[+]

Hawthorn polyphenols reduce high glucose-induced inflammation and apoptosis in ARPE-19 cells.Jan 31, 2021

Pubmed Data : J Food Biochem. 2021 Feb ;45(2):e13623. Epub 2021 Jan 24. PMID: 33491221
Article Published Date : Jan 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Polyphenols
Diseases : Diabetic Retinopathy, Hyperglycemia
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants
[+]

Hawthorn, onion and garlic may dissolve hydroxapatite crystals associated with arteriosclerosis. Jan 01, 2003

Pubmed Data : Folia Med Cracov. 2003;44(1-2):187-99. PMID: 15232901
Article Published Date : Jan 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Garlic, Hawthorn, Onion
Diseases : Arterial Calcification, Arteriosclerosis
Additional Keywords : Decalcification
[+]

In this review authors present current state of knowledge about possible beneficial effects of WS 1442 special extract on cardiovascular system.Jul 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Physiol Pharmacol. 2017 Aug ;68(4):521-526. PMID: 29151068
Article Published Date : Jul 31, 2017
Study Type : Review
Additional Links
Substances : Hawthorn
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective, Vasodilator Agents
Additional Keywords : Plant Extracts
[+]

Lignans from the seeds of Chinese hawthorn against β-amyloid aggregation.Jun 30, 2018

Pubmed Data : Nat Prod Res. 2018 Jul ;32(14):1706-1713. Epub 2017 Nov 8. PMID: 29115158
Article Published Date : Jun 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Lignans
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Major triterpenoids in Chinese hawthorn inhibited proliferation and induced apoptosis in MDA-MB-231 cancer cells.Jan 31, 2017

Pubmed Data : Food Chem Toxicol. 2017 Feb ;100:149-160. Epub 2016 Dec 23. PMID: 28025124
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Ursolic Acid
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, Cyclin D1 Down-Regulation
Additional Keywords : Antiproliferative, Breast Cancer: Triple Negative, Dose Response, Hawthorn, Ursolic Acid
[+]

Mexican hawthorn stems and leaves induce cell death on breast cancer cells.Oct 21, 2019

Pubmed Data : Nutr Cancer. 2019 Oct 22:1-11. Epub 2019 Oct 22. PMID: 31635496
Article Published Date : Oct 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
[+]

New constituents from the low polar fraction of the fruits of Crataegus dahurica and their anti-inflammatory activity in RAW264.7 cells.Jan 31, 2020

Pubmed Data : Chem Biodivers. 2020 Feb ;17(2):e1900609. Epub 2020 Jan 29. PMID: 31916412
Article Published Date : Jan 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Pectin oligosaccharides from hawthorn inhibit the formation of advanced glycation end products in infant formula milk powder.Dec 10, 2019

Pubmed Data : Food Funct. 2019 Dec 11 ;10(12):8081-8093. PMID: 31735943
Article Published Date : Dec 10, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Oligosaccharides
Diseases : Advanced Glycation End products (AGE)
Pharmacological Actions : Anti-Glycation Agents
Problem Substances : Infant Formula
[+]

Phenolic compounds from the leaves of Crataegus pinnatifida Bge. var. major N.E.Br. And their lipid-lowering effects.Aug 31, 2021

Pubmed Data : Bioorg Med Chem Lett. 2021 Sep 1 ;47:128211. Epub 2021 Jun 19. PMID: 34157392
Article Published Date : Aug 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Hyperlipidemia
Pharmacological Actions : Hypolipidemic
[+]

Phenylpropanoids from the fruit of Crataegus pinnatifida exhibit cytotoxicity on hepatic carcinoma cells through apoptosis induction.May 31, 2018

Pubmed Data : Fitoterapia. 2018 Jun ;127:301-307. Epub 2018 Mar 11. PMID: 29534982
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic
[+]

Polyphenol contents and antioxidant activities of extracts from flowers of two Crataegus azarolus L. varieties.Apr 30, 2009

Pubmed Data : Pak J Biol Sci. 2009 May 1 ;12(9):660-8. PMID: 19634468
Article Published Date : Apr 30, 2009
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Hawthorn, Polyphenols
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Polyphenolic compounds of Crataegus berry, leaf, and flower extracts affect viability and invasive potential of human glioblastoma cells.Apr 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 May 1 ;26(9). Epub 2021 May 1. PMID: 34062758
Article Published Date : Apr 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Polyphenols
Diseases : Glioblastoma
Pharmacological Actions : Apoptotic
[+]

Polyphenolic-polysaccharide conjugates from flowers and fruits of hawthorn have anticoagulant activity.Aug 31, 2018

Pubmed Data : Int J Biol Macromol. 2018 Sep ;116:869-879. Epub 2018 May 17. PMID: 29777813
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Polyphenols
Pharmacological Actions : Anticoagulants
Additional Keywords : Plant Extracts
[+]

Scientific evidence shows that WS 1442 is safe and has a beneficial effect in patients with heart failure.Jan 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Cardiovasc Drugs. 2018 Feb ;18(1):25-36. PMID: 29080984
Article Published Date : Jan 31, 2018
Study Type : Review
Additional Links
Substances : Flavonoids, Hawthorn
Diseases : Heart Failure
Pharmacological Actions : Cardioprotective
Additional Keywords : Phytotherapy, Plant Extracts
[+]

The results suggested that C. aronia L. could be used as a potential treatment against human lung cancer.Sep 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2020 Oct 1 ;21(10):2993-3003. Epub 2020 Oct 1. PMID: 33112559
Article Published Date : Sep 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Lung Cancer
Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

These findings suggest that C. azarolus should be explored as a novel potential immunomodulatory agent for the treatment of inflammatory diseases.May 31, 2016

Pubmed Data : Tumour Biol. 2016 Jun ;37(6):7967-80. Epub 2015 Dec 28. PMID: 26711781
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Immunomodulatory
Additional Keywords : Plant Extracts
[+]

Total Flavonoid extract from hawthorn improves inflammatory cytokines-evoked epithelial barrier deficit.Feb 16, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2020 Feb 17 ;26:e920170. Epub 2020 Feb 17. PMID: 32065826
Article Published Date : Feb 16, 2020
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Copyright: marilyna / 123RF Stock Photo

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