Hawthorn

Name	AC	CK
Heart Failure	7	44
Congestive Heart Failure	3	21
Oxidative Stress	15	21
Diabetes Mellitus: Type 2	5	17
DNA damage	3	12
Inflammation	9	12
Coronary Artery Disease	2	11
Hypertension	6	11
Lipid Peroxidation	2	11
Radiation Induced Illness	2	11
C-Reactive Protein	1	10
Hyperlipidemia	6	10
Left Ventricular Dysfunction	1	10
Nonalcoholic fatty liver disease (NAFLD)	6	10
Alzheimer's Disease	5	8
Myocardial Ischemia	4	7
Obesity	4	7
Breast Cancer: Triple Negative	2	6
Hypercholesterolemia	3	6
High Fat Diet	3	5
Aging	2	4
Chemotherapy-Induced Toxicity: Doxorubicin	2	4
Colitis	2	4
Depression	2	4
Diabetes Mellitus: Type 1	2	4
Diabetic Nephropathy	2	4
Dysbiosis	2	4
Ultraviolet Radiation Induced Damage	2	4
Alcoholic Liver Disease	2	3
Arteriosclerosis	2	3
Atherosclerosis	2	3
Cardiovascular Diseases	3	3
Chemically-Induced Liver Damage	2	3
Dyslipidemias	2	3
High Cholesterol	2	3
High Fructose Diet	2	3
Hyperglycemia	3	3
Liver Cancer	3	3
Aging Skin	1	2
Arrhythmias: Cardiac	1	2
Breast Cancer	2	2
Cholesterol: Oxidation	1	2
Colorectal Cancer	2	2
Constipation	1	2
Diabetes Mellitus: Type 2: Prevention	1	2
Diabetes: Cognitive Dysfunction	1	2
Diabetic Complications	1	2
Diarrhea	1	2
Gastric Ulcer	1	2
Glyphosate Toxicity	1	2
Gram-Positive Bacterial Infections	1	2
Hair Loss	1	2
Hydrogen Peroxide Induced Toxicity	2	2
Insulin Resistance	2	2
Liver Cirrhosis	1	2
Liver Fibrosis	1	2
Liver Steatosis	1	2
Metabolic Diseases	1	2
Neurodegenerative Diseases	2	2
Osteoarthritis	1	2
Osteoporosis	1	2
Pesticide Toxicity	1	2
Space Flight Associated Adverse Changes	1	2
Spinal Cord Injuries	1	2
Ulcerative Colitis	1	2
Advanced Glycation End products (AGE)	1	1
Alcohol Toxicity	1	1
Arterial Calcification	1	1
Brain Inflammation	1	1
Brain: Oxidative Stress	1	1
Cancers: All	1	1
Congestive Heart Failure: NYHA functional class II	1	1
Diabetes: Oxidative Stress	1	1
Diabetic Retinopathy	1	1
Gastrointestinal Cancer	1	1
Gaucher Disease	1	1
Glioblastoma	1	1
Heart Disease	1	1
Lipid Metabolism: Abnormalities	1	1
Lipopolysaccharide-Induced Toxicity	1	1
Liver Damage	1	1
Lung Cancer	1	1
Metabolic Syndrome X	1	1
Myocardial Infarction	1	1
Promyelocytic leukemia	1	1
Radiation Induced Illness: Bone Marrow	1	1
Tay-Sachs Disease	1	1

Name	AC	CK
Antioxidants	42	68
Anti-Inflammatory Agents	26	41
Hypolipidemic	17	34
Hepatoprotective	14	23
Neuroprotective Agents	12	18
Cardioprotective	11	16
Gastrointestinal Agents	8	14
Tumor Necrosis Factor (TNF) Alpha Inhibitor	7	12
Radioprotective	2	11
Antihypertensive Agents	5	10
Interleukin-1 beta downregulation	6	10
Interleukin-6 Downregulation	6	10
Antiproliferative	5	9
Hypoglycemic Agents	6	9
Apoptotic	7	7
Wnt/β-catenin signaling pathway modulation	2	7
Anticholesteremic Agents	3	6
Nrf2 activation	3	6
NF-kappaB Inhibitor	3	5
Superoxide Dismutase Up-regulation	3	5
Anti-Apoptotic	3	4
Antidepressive Agents	2	4
Chemoprotective Agents	2	4
Heme oxygenase-1 up-regulation	2	4
Immunomodulatory	3	4
Photoprotective	2	4
Anti-Fibrotic	2	3
Malondialdehyde Down-regulation	2	3
Vasodilator Agents	3	3
Anti-atherogenic	1	2
Antidiarrheals	1	2
Bax/Bcl2 ratio: Increase	1	2
Chemopreventive	2	2
Cyclooxygenase 2 Inhibitors	1	2
Enzyme Inhibitors	1	2
Interleukin-1 alpha downregulation	1	2
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	2
MicroRNA modulator	1	2
Osteoprotective	1	2
Renoprotective	1	2
SIRT1 Activator	1	2
Transforming growth factor beta (TGF-β) upregulation	1	2
anti-inflammatory	1	2
Acetylcholinesterase Inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Angiogenesis Inducing Agents	1	1
Anti-Glycation Agents	1	1
Anticoagulants	1	1
Antineoplastic Agents	1	1
Caspase-3 Activation	1	1
Caspase-9 Activation	1	1
Cell cycle arrest	1	1
Chemosensitizer	1	1
Chemotherapeutic	1	1
Cyclin D1 Down-Regulation	1	1
Insulin Sensitizers	1	1
Interleukin-8 downregulation	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1
Pancreato Protective Agents	1	1
Regenerative	1	1

[+]

C. laevigata decreased neutrophil elastase and showed a trend to lower LDL-C.Jun 14, 2011

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Pubmed Data : Phytomedicine. 2011 Jun 15 ;18(8-9):769-75. Epub 2011 Jan 15. PMID: 21242072

Article Published Date : Jun 14, 2011

Study Type : Human Study

Additional Links

Substances : Hawthorn

Diseases : C-Reactive Protein, Coronary Artery Disease, Diabetes Mellitus: Type 2, Lipid Peroxidation

Pharmacological Actions : Hypolipidemic

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Hawthorn (Crataegus) reduces the incidence of sudden cardiac death in patients with less compromised left ventricular function.Dec 01, 2008

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Pubmed Data : Eur J Heart Fail. 2008 Dec;10(12):1255-63. Epub 2008 Nov 18. PMID: 19019730

Pubmed Data : Radiat Environ Biophys. 2009 Feb;48(1):95-8. Epub 2008 Sep 4. PMID: 18769933

Article Published Date : Feb 01, 2009

Pubmed Data : Appl Biochem Biotechnol. 2022 Mar 9. Epub 2022 Mar 9. PMID: 35262883

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Pubmed Data : IBRO Rep. 2019 Dec ;7:90-96. Epub 2019 Oct 22. PMID: 31720488

Article Published Date : Nov 30, 2019

Study Type : Animal Study

Additional Links

Substances : Hawthorn

Diseases : Diabetes: Cognitive Dysfunction

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic, Neuroprotective Agents

[+]

Effect of flavonoids in hawthorn and vitamin C prevents hypertension in rats induced by heat exposure.Jan 26, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacotherapy. 2009 Jun;29(6):639-48. PMID: 19476417

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Hawthorn

Diseases : Heart Failure

Additional Keywords : Plant Extracts

[+]

Hawthorn extract could have protective effects in ovariectomized rats.May 12, 2016

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Pubmed Data : Helicobacter. 2005 Apr;10(2):139-45. PMID: 10960896

Article Published Date : Apr 01, 2005

Study Type : Animal Study

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Substances : Hawthorn

Diseases : Arrhythmias: Cardiac

[+]

Hawthorn fruit acid consumption attenuates hyperlipidemia-associated oxidative damage in rats.Dec 31, 2021

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Pubmed Data : Front Nutr. 2022 ;9:936229. Epub 2022 Aug 3. PMID: 35990322

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Hawthorn

Diseases : Hyperlipidemia

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

[+]

Hawthorn fruit extract ameliorates H2O2-induced oxidative damage in neuronal PC12 cells and prolongs the lifespan.Oct 16, 2022

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Pubmed Data : Food Funct. 2022 Oct 17 ;13(20):10680-10694. Epub 2022 Oct 17. PMID: 36172739

Hawthorne leaf flavonoids prevent oxidative stress injury of renal tissues in rats with diabetic kidney disease.Dec 31, 2018

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Pubmed Data : Biomed Pharmacother. 2022 Sep ;153:113411. Epub 2022 Jul 19. PMID: 36076481

Article Published Date : Aug 31, 2022

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Pubmed Data : Food Chem. 2023 Jul 1 ;413:135658. Epub 2023 Feb 9. PMID: 36780857

Article Published Date : Jun 30, 2023

Study Type : Animal Study

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Substances : Hawthorn

Pharmacological Actions : Immunomodulatory

Additional Keywords : Polysaccharides

[+]

The Crataegus azarolus berries aqueous extract significantly protected against diarrhea.Dec 14, 2020

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Pubmed Data : Neurogastroenterol Motil. 2020 Dec 15:e14065. Epub 2020 Dec 15. PMID: 33320393

Article Published Date : Dec 14, 2020

Study Type : Animal Study

Additional Links

Substances : Hawthorn

Diseases : Diarrhea

Pharmacological Actions : Anti-Inflammatory Agents, Antidiarrheals, Antioxidants

Problem Substances : Hydrogenated Castor Oil

[+]

The effects of Crataegus pinnatifida and Wolfiporia extensa combination on diet-induced obesity.May 23, 2024

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Pubmed Data : Foods. 2024 May 24 ;13(11). Epub 2024 May 24. PMID: 38890862

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Pubmed Data : Food Funct. 2019 Feb 20 ;10(2):849-858. PMID: 30681096

Article Published Date : Feb 19, 2019

Study Type : Animal Study

Additional Links

Substances : Hawthorn

Diseases : Hypertension, Oxidative Stress

Pharmacological Actions : Antihypertensive Agents, Antioxidants

Additional Keywords : Plant Extracts

[+]

The results of this study demonstrate that hawthorn leaves and flowers are a promising treatment for hypercholesterolemia.Dec 31, 2011

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Pubmed Data : Nat Prod Res. 2019 Aug 20:1-4. Epub 2019 Aug 20. PMID: 31429298

Article Published Date : Aug 19, 2019

Study Type : In Vitro Study

Additional Links

Substances : Hawthorn

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

A review of the effects of Chinese hawthorn on metabolic syndrome.Apr 30, 2019

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Pubmed Data : Iran J Basic Med Sci. 2019 May ;22(5):460-468. PMID: 31217924

Article Published Date : Apr 30, 2019

Study Type : Review

Additional Links

Substances : Hawthorn

Diseases : Atherosclerosis, Dyslipidemias, Metabolic Syndrome X, Obesity

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic

[+]

A study on the treatment effects of Crataegus pinnatifida polysaccharide on non-alcoholic fatty liver.Dec 31, 2023

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Pubmed Data : Front Vet Sci. 2024 ;11:1383801. Epub 2024 Mar 27. PMID: 38601914

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[+]

Insight into isolation and characterization of phenolic compounds from hawthorn.Aug 18, 2022

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Pubmed Data : Plant Foods Hum Nutr. 2022 Aug 19. Epub 2022 Aug 19. PMID: 35986175

Polyphenolic compounds of Crataegus berry, leaf, and flower extracts affect viability and invasive potential of human glioblastoma cells.Apr 30, 2021

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Scientific evidence shows that WS 1442 is safe and has a beneficial effect in patients with heart failure.Jan 31, 2018

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Pubmed Data : Am J Cardiovasc Drugs. 2018 Feb ;18(1):25-36. PMID: 29080984

Article Published Date : Jan 31, 2018

Study Type : Review

Additional Links

Substances : Flavonoids, Hawthorn

Diseases : Heart Failure

Pharmacological Actions : Cardioprotective

Additional Keywords : Phytotherapy, Plant Extracts

[+]

The results suggested that C. aronia L. could be used as a potential treatment against human lung cancer.Sep 30, 2020

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View the Evidence: 121 Abstracts with Hawthorn Research

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C. laevigata decreased neutrophil elastase and showed a trend to lower LDL-C.Jun 14, 2011

Hawthorn (Crataegus) reduces the incidence of sudden cardiac death in patients with less compromised left ventricular function.Dec 01, 2008

Hawthorn berry extract is safe and effective in improving exercise tolerance and quality of life in patients with congestive heart failure Oct 01, 2001

Hawthorn berry improves symptoms in patients with congestive heart failure. Sep 26, 2007

Hawthorn protects against gamma radiation induced genotoxicity in human blood lymphocytes.Feb 01, 2009

Hawthorn provides benefits as an adjunctive treatment for chronic heart failure. - Article 1Jun 01, 2003

Hawthorn provides benefits as an adjunctive treatment for chronic heart failure. - Article 2Jan 23, 2008

In vitro anti-cancer effect of Crataegus oxyacantha berry extract on hormone receptor positive and triple negative breast cancers.Mar 08, 2022

Hyperoside Prevents Aβ42-Induced Neurotoxicity in PC12 Cells and Caenorhabditis elegans.Nov 30, 2023

A herbal complex is an effective herbal formulation in the attenuation of obesity and obesity-induced metabolic dysfunction including NAFLD.Jan 07, 2021

A phenol-rich fraction of hawthorn fruit exhibited satisfactory hypolipidemic and antioxidant effects.Sep 30, 2017

Antihypertensive effects of hydroalcoholic extract of Crataegus Azarolus subspecies Aronia fruit in rats with renovascular hypertension.Apr 30, 2017

Anxiolytic and antidepressants' effect of Crataegus pinnatifida.Jan 18, 2022

Astragalus polysaccharides combined with Crataegus flavonoids may facilitate the treatment of type 1 or 2 diabetes.Apr 14, 2016

Beneficial effects of crataegus oxyacantha extract on neurobehavioral deficits and brain tissue damages induced by an insecticide mixtures.May 31, 2019

C. aronia exhibits therapeutic and protective effects on NAFLD in an animal model.Jul 15, 2016

C. aronia inhibits high fat diet-induced vascular inflammation.Nov 30, 2019

C. oxyacantha has both a therapeutic and a protective effect for NAFLD.May 01, 2018

Cardioprotective effect of resistance training and Crataegus oxyacantha extract on ischemia reperfusion-induced oxidative stress in diabetic rats.Mar 31, 2018

Chemical basis of hawthorn processed with honey protecting against myocardial ischaemia.Mar 31, 2020

Chemoprevention with a tea from hawthorn leaves and flowers attenuates colitis.Jan 29, 2021

Chinese hawthorn fruit reduces inflammation and oxidative stress in rats with doxorubicin-Induced chronic heart failure.Nov 23, 2020

Chlorogenic acid and Crataegus pinnatifida extracts prevented depressive behaviour and thereby have potential as natural antidepressants.Jun 11, 2018

Corosolic acid ameliorates non-alcoholic steatohepatitis induced by high-fat diet and carbon tetrachloride.Aug 31, 2021

Crataegus aronia prevents high-fat diet-induced hepatic steatosis.Jan 10, 2021

Crataegus azarolus berry extract protected against acetic acid-induced ulcerative colitis.Dec 31, 2023

Crataegus pinnatifida Bunge could be a potential alternative medicine for bone diseases.Dec 31, 2020

Crataegus pinnatifida polysaccharide alleviates colitis via modulation of gut microbiota and SCFAs metabolism.Mar 23, 2021

Crataegus sinaica defatted methanolic extract ameliorated monosodium iodoacetate-induced oxidative stress andinhibited inflammation.Sep 30, 2022

Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters.Nov 30, 2019

Effect of flavonoids in hawthorn and vitamin C prevents hypertension in rats induced by heat exposure.Jan 26, 2022

Effects of hawthorn seed oil on plasma cholesterol and gut microbiota.Aug 11, 2022

Hair growth activity of Crataegus pinnatifida on C57BL/6 mouse model.Aug 31, 2013

Hawthorn and kiwi fruit extracts are superior to simvastatin in lowering cholesterol in mice fed a high cholesterol diet.Jan 01, 2009

Hawthorn and Rosemary treatments have different mechanisms of action; however they show hepatoprotective effect against alcoholic liver disease.Jun 30, 2019

Hawthorn could partially restore liver histomorphology and has anti-hypertensive effect by regulating lipid metabolism.Dec 31, 2021

Hawthorn demonstrates a modest beneficial effects on cardiac remodeling and function during long-term, pressure overload-induced heart failure in rats.Jun 01, 2009

Hawthorn extract could have protective effects in ovariectomized rats.May 12, 2016

Hawthorn extract has the potential to become a functional food or an alternative therapy for hypertension.May 19, 2024

Hawthorn extract represents a useful agent for the prevention or treatment of T2DM.Mar 22, 2017

Hawthorn extracts are able to protect from hypercholesterolemia-induced oxidative stress and hepatic injuries.Jun 30, 2015

Hawthorn flower extract has hypotensive and potential antiarrhtymic action. Apr 01, 2005

Hawthorn fruit acid consumption attenuates hyperlipidemia-associated oxidative damage in rats.Dec 31, 2021

Hawthorn fruit extract ameliorates H2O2-induced oxidative damage in neuronal PC12 cells and prolongs the lifespan.Oct 16, 2022

Hawthorn fruit, especially its peel, is an excellent source of natural chemopreventive agents in the treatment of liver disorders.Aug 12, 2016

Hawthorn has anti-inflammatory, gastroprotective, free-radical-scavenging, and antimicrobial activities. Sep 10, 2008

Hawthorn herbal preparation from Crataegus oxyacantha attenuates carbon tetrachloride-induced hepatic fibrosis.Nov 23, 2020

Hawthorn leave flavonoids can slow down the development of atherosclerosis in apoE knockout mice.Feb 22, 2017

Hawthorn leaves flavonoids attenuate cardiac remodeling induced by simulated microgravity.Nov 30, 2023

Hawthorn polyphenol extract could be used as a functional food component in the adjuvant treatment of T2D.Mar 31, 2021

Hawthorn polyphenol extract inhibits UVB-induced skin photoaging.Aug 14, 2018

Hawthorn-leaf flavonoid alleviate intestinal health and microbial dysbiosis problems induced by glyphosate.Aug 21, 2024

Hawthorne leaf flavonoids prevent oxidative stress injury of renal tissues in rats with diabetic kidney disease.Dec 31, 2018

Hepatoprotective effects of Algerian Crataegus oxyacantha leaves.Jul 28, 2018

In vivo effects of Crataegus pinnatifida extract for healthy longevity. May 27, 2023

Interval training and Crataegus persica ameliorate diabetic nephropathy.Aug 31, 2022

Investigation on the lipid-lowering effect and mechanism by combining turmeric with hawthorn in C57BL/6 obese mice.Jun 30, 2024

Soluble dietary fiber of hawthorn relieves constipation induced by loperamide hydrochloride.Jul 14, 2024

Structural characterization of a heteropolysaccharide from the fruit of Crataegus pinnatifida and its bioactivity on the gut microbiota of immunocompromised mice.Jun 30, 2023

The Crataegus azarolus berries aqueous extract significantly protected against diarrhea.Dec 14, 2020

The effects of Crataegus pinnatifida and Wolfiporia extensa combination on diet-induced obesity.May 23, 2024

The fruit of Crataegus pinnatifida ameliorates memory deficits in β-amyloid protein-induced Alzheimer's disease model.Jul 22, 2019

The lipid-lowering effects of fenugreek gum, hawthorn pectin, and burdock inulin.Dec 31, 2022

The protective role of hawthorn fruit extract against high salt-induced hypertension.Feb 19, 2019

The results of this study demonstrate that hawthorn leaves and flowers are a promising treatment for hypercholesterolemia.Dec 31, 2011

These findings suggest that hawthorn polyphenol extract can be used as the base ingredient for antiphotoaging food products.Jan 31, 2019

Total flavonoids of hawthorn leaves protect spinal motor neurons.Dec 31, 2021

A new dineolignan with anti-β-amyloid aggregation activity from the fruits of crataegus pinnatifida bge.Aug 19, 2019

A review of the effects of Chinese hawthorn on metabolic syndrome.Apr 30, 2019

A study on the treatment effects of Crataegus pinnatifida polysaccharide on non-alcoholic fatty liver.Dec 31, 2023

All data reviewed indicate that hawthorn is well tolerated, but more data are needed on concomitant use of hawthorn and other medications.Jan 01, 2006

Antioxidant activity of Crataegus aronia aqueous extract used in traditional Arab medicine in Israel.Oct 02, 2005

Hawthorn

View the Evidence:
121 Abstracts with Hawthorn Research