Hesperidin

Name	AC	CK
Hemorrhoids	7	61
Oxidative Stress	15	39
Metabolic Syndrome X	4	23
Inflammation	8	21
Hypertension	5	16
Obesity	5	15
Liver Cancer	8	13
Athletic Performance	2	12
Depression	6	12
Exercise-Induced Tissue Damage	2	12
Chronic Venous Insufficency	2	11
Venous Ulcer	2	11
Aphthous Ulcer	1	10
Bladder Degeneration	1	10
Brain Inflammation	5	10
Cerebral Hemorrhage	1	10
Chronic Pelvic Pain Syndrome	1	10
Diabetes Mellitus: Type 2: Prevention	1	10
Epistaxis	1	10
Hematuria	1	10
Leg Ulcer	1	10
Nonalcoholic fatty liver disease (NAFLD)	1	10
Nose Bleed	1	10
Pelvic Inflammatory Disease	1	10
Postoperative Recovery	1	10
Prediabetes	1	10
Prehypertension	1	10
Stroke: Ischemic	1	10
Ultraviolet Radiation Induced Damage	2	10
Vericose Veins: Bladder	1	10
Coronavirus Infection	8	8
Ischemia	4	8
Lipid Peroxidation	4	8
Radiation Induced Illness	5	8
Alzheimer's Disease	4	7
Diabetic Complications	4	7
Aluminum Toxicity	3	6
Brain: Oxidative Stress	3	6
Chemically-Induced Liver Damage	3	6
Drug Toxicity: Methotrexate	3	6
Gastric Ulcer	3	6
Osteoporosis	3	6
Atherosclerosis	3	5
Breast Cancer	4	5
Cancers: All	4	5
Chemotherapy and Radiation Toxicity	3	5
Diabetes Mellitus: Type 2	3	5
Hyperglycemia	3	5
Osteoarthritis	3	5
Parkinson's Disease	3	5
Rheumatoid Arthritis	3	5
Alcohol Toxicity	2	4
Chemotherapy-Induced Toxicity: Cisplatin	2	4
Colon Cancer	2	4
DNA damage	2	4
Diabetes Mellitus: Type 1	2	4
Diabetic Ulcer	2	4
Ehrlich carcinoma	2	4
Kidney Damage	2	4
Kidney Damage: Chemically-Induced	2	4
Myocardial Ischemia	2	4
Oral Cancer	2	4
Radiation	3	4
Sepsis	2	4
Tongue Cancer	2	4
Cardiovascular Diseases	2	3
Chemotherapy-Induced Toxicity: Cyclophosphamide	2	3
Colitis	2	3
Diabetic Retinopathy	3	3
Influenza A	2	3
Kidney Cancer	2	3
Lipopolysaccharide-Induced Toxicity	2	3
Multiple Sclerosis	2	3
Skin Cancer	2	3
Acrylamide-induced toxicity	1	2
Acute Respiratory Distress Syndrome	1	2
Advanced Glycation End products (AGE)	1	2
Allergic Rhinitis	1	2
Arterial Hardening: Elasticity	1	2
Arthritis: Rheumatoid	1	2
Brain Injury: Traumatic	1	2
C-Reactive Protein	1	2
Cancers: Drug Resistant	1	2
Cardiac Hypertrophy	1	2
Cardiomyopathy	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Chronic Obstructive Pulmonary Disease	1	2
Chronic Pain	1	2
Cognitive Decline/Dysfunction	1	2
Constipation	1	2
Endothelial Dysfunction	1	2
Epilepsy	1	2
Epilepsy: Drug-Induced	1	2
Fatty Liver	1	2
Gastric Cancer	1	2
Gastrointestinal Inflammation	1	2
Gastrointestinal Surgical Procedures	1	2
Gout	1	2
Hepatic Steatosis	1	2
High Fat Diet	1	2
Hydrogen Peroxide Induced Toxicity	1	2
Hyperlipidemia	1	2
Hyperuricemia	1	2
Insulin Resistance	2	2
Iron Overload	1	2
Kidney Damage: Drug-Induced	1	2
Liver Cirrhosis	1	2
Liver Damage: Drug-Induced	1	2
Liver Fibrosis	1	2
Liver Injury: Ischemia/reperfusion	1	2
Lung Cancer	1	2
Lung Cancer: Prevention	1	2
Lymphatic Diseases	1	2
Lymphatic Stasis	1	2
Lymphedema	1	2
Memory Disorders	1	2
Motion Sickness	1	2
Neurodegenerative Diseases	2	2
Neuropathic Pain	1	2
Osteosarcoma	1	2
Otitis media	1	2
Pancreatic Cancer	1	2
Pancreatitis	1	2
Periodontitis	1	2
Pesticide Toxicity	1	2
Petroleum Exposure And Toxicity	1	2
Pleurisy	1	2
Post-Traumatic Stress Disorders (PTSD)	1	2
Proctitis	1	2
Psoriasis	1	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Spinal Cord Injuries	1	2
Squamous cell carcinoma	1	2
Subarachnoid hemorrhage	1	2
Sugar (Sucrose) Toxicity	1	2
Ulcerative Colitis	1	2
Ulcers	1	2
Vaccine-induced Toxicity	1	2
Varicocele	1	2
Wound Healing	1	2
Acute Myeloid Leukemia	1	1
Adiponectin: Low Levels	1	1
Aging	1	1
Allergic Airway Diseases	1	1
Amyotrophic Lateral Sclerosis	1	1
Amyotrophic lateral sclerosis (ALS)	1	1
Animal Diseases: Canine Distemper Virus	1	1
Asthma	1	1
Breast Cancer: Triple Negative	1	1
Cartilage Diseases	1	1
Central Nervous System Diseases	1	1
Chikungunya Virus	1	1
Coronavirus Disease	1	1
Diabetes: Oxidative Stress	1	1
Gallbladder Cancer	1	1
Glioma	1	1
HIV Infections	1	1
Hypoglycemia	1	1
Influenza	1	1
Leishmaniasis	1	1
Liver Cancer: Prevention	1	1
Neuroblastoma	1	1
Neutropenia	1	1
Neutropenia: Chemotherapy Induced	1	1
Non-Small-Cell Lung Carcinoma	1	1
Promyelocytic leukemia	1	1
Prostate Cancer	1	1
Surgery: Anesthesiology	1	1
Zika Virus	1	1

Name	AC	CK
Anti-Inflammatory Agents	58	143
Antioxidants	56	124
Tumor Necrosis Factor (TNF) Alpha Inhibitor	24	52
Neuroprotective Agents	19	42
Hepatoprotective	12	31
Interleukin-1 beta downregulation	15	30
Hypolipidemic	8	29
NF-kappaB Inhibitor	11	28
Interleukin-6 Downregulation	13	23
Anti-Apoptotic	11	22
Antihypertensive Agents	3	22
Cardioprotective	7	22
Chemopreventive	12	20
Hypoglycemic Agents	8	20
Radioprotective	11	18
Anticarcinogenic Agents	10	17
Renoprotective	9	17
Nrf2 activation	9	16
Antiproliferative	9	13
Matrix metalloproteinase-9 (MMP-9) inhibitor	4	13
Antidepressive Agents	6	12
Apoptotic	10	12
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	11
Analgesics	1	10
Antiviral Agents	10	10
Chemoprotective Agents	5	10
Insulin Sensitizers	1	10
Photoprotective	2	10
Transforming growth factor beta (TGF-β) inhibitor	1	10
Cyclooxygenase 2 Inhibitors	5	9
Anti-Ulcer Agents	4	8
Immunomodulatory	5	8
Superoxide Dismutase Up-regulation	4	8
Chemosensitizer	4	6
Heme oxygenase-1 up-regulation	4	6
Malondialdehyde Down-regulation	3	6
Osteoprotective	3	6
Gastroprotective	3	5
Interleukin-4 downregulation	3	5
Nitric Oxide Inhibitor	3	5
Anti-metastatic	3	4
Brain-derived neurotrophic factor modulator	2	4
Catalase Up-Regulation	2	4
Cell cycle arrest	3	4
Gastrointestinal Agents	2	4
MicroRNA modulator	3	4
Neurogenesis	2	4
Postaglandin PGE2 downregulation	2	4
Prophylactic Agents	3	4
Chemotherapeutic	3	3
Interleukin-10 downregulation	2	3
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	2	3
Angiogenesis Inducing Agents	1	2
Anti-Angiogenic	1	2
Anti-Fibrotic	1	2
Anti-Glycation Agents	1	2
Anticonvulsants	1	2
Antinoceceptive	1	2
Autophagy Inhibitors	1	2
Dermatologic Agents	1	2
Genoprotective	1	2
Glutathione Upregulation	1	2
Heat Shock Protein Down-Regulation	1	2
Histamine up-regulation	1	2
Laxative	1	2
Lymphagogue	1	2
Nitric Oxide Enhancer	1	2
Pancreato Protective Agents	1	2
Vascular Endothelial Growth Factor C Inhibitor	1	2
Vascular Endothelial Growth Factor Inhibitors	1	2
Vascular Endothelial Growth Factor Regulator	1	2
Vasodilator Agents	1	2
Wnt/β-catenin signaling pathway modulation	1	2
Acetylcholinesterase Inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Anti-Asthmatic Agents	1	1
Bcl-2 protein down-regulation	1	1
C-Jun N-Terminal Kinases (JNK) Modulator	1	1
Chondroprotective	1	1
Enzyme Inhibitors	1	1
Enzyme Inhibitors: Pancreatic Lipase	1	1
Expectorants	1	1
Extracellular Signal-Regulated Kinases Modulator	1	1
Inhibitor of Nuclear Factor Kappa-B Kinase (IKK)	1	1
Interferon Gamma Reducer	1	1
Interleukin-5 downregulation	1	1
Leishmanicidal	1	1
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	1
NF-kappa-B-inducing kinase (NIK) modulator	1	1
Neurominidase Inhibitor	1	1
P21 Activation	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
Prostaglandin PGE2 downregulation	1	1
Protease Inhibitors	1	1

[+]

8 weeks of 2 S-Hesperidin supplementation improves muscle mass and reduces fat in amateur competitive cyclists.May 10, 2021

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Pubmed Data : Food Funct. 2021 May 11 ;12(9):3872-3882. PMID: 33977947

Article Published Date : May 10, 2021

Study Type : Human Study

Additional Links

Substances : Hesperidin

Diseases : Athletic Performance

Therapeutic Actions : Exercise: Cycling

[+]

8-week supplementation of 2S-hesperidin modulates antioxidant and inflammatory status after exercise until exhaustion in amateur cyclists.Mar 10, 2021

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Pubmed Data : Antioxidants (Basel). 2021 Mar 11 ;10(3). Epub 2021 Mar 11. PMID: 33799833

Article Published Date : Mar 10, 2021

Study Type : Human Study

Additional Links

Substances : Hesperidin

Diseases : Exercise-Induced Tissue Damage, Inflammation, Oxidative Stress

Therapeutic Actions : Exercise: Cycling

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

A combination of 500-mg G-hesperidin and 75-mg caffeine for 12 weeks significantly reduced abdominal fat.Dec 31, 2015

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Pubmed Data : Nutr J. 2016 ;15(1):6. Epub 2016 Jan 19. PMID: 26786000

Pubmed Data : Eur J Nutr. 2020 Apr 15. Epub 2020 Apr 15. PMID: 32296931

Article Published Date : Apr 14, 2020

Study Type : Human Study

Additional Links

Substances : Flaxseed, Hesperidin

Diseases : Metabolic Syndrome X

Pharmacological Actions : Hypolipidemic, Insulin Sensitizers

Additional Keywords : Natural Substance Synergy

[+]

Combination therapy of flaxseed and hesperidin enhances the effectiveness of lifestyle modification in cardiovascular risk control in prediabetes.Jan 05, 2021

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Pubmed Data : Diabetol Metab Syndr. 2021 Jan 6 ;13(1):3. Epub 2021 Jan 6. PMID: 33402222

Article Published Date : Jan 05, 2021

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Pubmed Data : Mol Nutr Food Res. 2021 Jul 17:e2001175. Epub 2021 Jul 17. PMID: 34272817

Reversal of insulin resistance in overweight and obese subjects by trans-resveratrol and hesperetin combination.Jul 10, 2021

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Pubmed Data : Nutrients. 2021 Jul 11 ;13(7). Epub 2021 Jul 11. PMID: 34371884

Article Published Date : Jul 10, 2021

Study Type : Human Study

Additional Links

Substances : Hesperidin, Resveratrol

Diseases : Dyslipidemias, Hypertension, Inflammation, Insulin Resistance, Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Supplementation with an orange extract (2S-hesperdin) 500 mg/day improves estimated FTP and maximum power performance in amateur cyclists.Dec 20, 2020

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Pubmed Data : Nutrients. 2020 Dec 21 ;12(12). Epub 2020 Dec 21. PMID: 33371483

Article Published Date : Dec 20, 2020

Study Type : Human Study

Additional Links

Substances : Hesperidin

Diseases : Athletic Performance

Therapeutic Actions : Exercise: Cycling

[+]

The combined effect of green tea and α-glucosyl hesperidin in preventing obesity.Jan 23, 2021

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Pubmed Data : Sci Rep. 2021 09 24 ;11(1):19067. Epub 2021 Sep 24. PMID: 34561541

Article Published Date : Jan 23, 2021

Study Type : Human Study

Additional Links

Substances : Green Tea, Hesperidin

Diseases : Obesity

Therapeutic Actions : Placebo Effect

Additional Keywords : Anti-Obesity Agents

[+]

The effect of dietary antioxidant supplementation in patients with glaucoma.Dec 31, 2020

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Pubmed Data : Acta Chir Belg. 2004 Nov-Dec;104(6):715-8. PMID: 15663281

Article Published Date : Nov 01, 2004

Study Type : Animal Study

Additional Links

Substances : Diosmin , Hesperidin

Diseases : Gastrointestinal Surgical Procedures

[+]

A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury.Dec 31, 2015

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Pubmed Data : Front Pharmacol. 2018 ;9:1028. Epub 2018 Sep 11. PMID: 30254586

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

[+]

Hesperetin promotes cisplatin-induced apoptosis of gastric cancer.Dec 31, 2019

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Pubmed Data : Exp Toxicol Pathol. 2017 Jan 26. Epub 2017 Jan 26. PMID: 28132802

Article Published Date : Jan 25, 2017

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Diabetes Mellitus: Type 1, Osteoporosis

Pharmacological Actions : Osteoprotective , Prophylactic Agents

Additional Keywords : Risk Reduction

[+]

Hesperidin could be used to enhance wound healing in chronic diabetic foot ulcers.Dec 31, 2017

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Pubmed Data : Life Sci. 2017 Jul 25. Epub 2017 Jul 25. PMID: 28754618

Article Published Date : Jul 24, 2017

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Liver Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Wnt/β-catenin signaling pathway modulation

[+]

Hesperidin has a protective effect on sodium arsenite-induced nephrotoxicity and hepatotoxicity.Jul 30, 2018

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Pubmed Data : Biol Trace Elem Res. 2018 Jul 31. Epub 2018 Jul 31. PMID: 30066062

Article Published Date : Sep 30, 2016

Study Type : Animal Study

Additional Links

Substances : Hesperidin, Nuts

Diseases : Breast Cancer, Kidney Cancer, Liver Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

[+]

Hesperidin reduces the effects of ischemia/reperfusion injury damage.Sep 30, 2016

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Pubmed Data : Eur J Nutr. 2020 May 27. Epub 2020 May 27. PMID: 32462317

Article Published Date : May 26, 2020

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Metabolic Syndrome X

Pharmacological Actions : Cardioprotective

[+]

Hesperidin was found to offer protection against γ-irradiation induced pulmonary damage.Aug 31, 2016

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Pubmed Data : J Biomed Phys Eng. 2016 Sep ;6(3):165-174. Epub 2016 Sep 1. PMID: 27853724

Article Published Date : Aug 31, 2016

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Chemotherapy and Radiation Toxicity

Pharmacological Actions : Radioprotective

[+]

Hesperidin, a flavonoid obtained from citrus fruits, has sedative properties. Mar 01, 2009

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Pubmed Data : : Planta Med. 2009 Mar;75(4):295-301. Epub 2009 Feb 13. PMID: 19219759

Article Published Date : Mar 01, 2009

Study Type : Animal Study

Additional Links

Substances : Hesperidin

[+]

Hesperidin, a novel candidate for the successful treatment of high fat diet plus ethanol-induced fatty liver disease.Mar 31, 2021

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Pubmed Data : J Physiol Pharmacol. 2021 Apr ;72(2). Epub 2021 Aug 6. PMID: 34374658

Article Published Date : Mar 31, 2021

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Liver: Fatty

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

[+]

Hesperidin-rich ethanol extract from waste peels of Citrus limetta mitigates rheumatoid arthritis and related complications.May 31, 2021

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Pubmed Data : Phytother Res. 2021 Jun ;35(6):3325-3336. Epub 2021 Feb 24. PMID: 33624898

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Pubmed Data : Oxid Med Cell Longev. 2021 ;2021:9990091. Epub 2021 Aug 11. PMID: 34422219

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Citrus naringin, Hesperidin

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Diclofenac

[+]

Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity.Apr 30, 2022

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Pubmed Data : Neurotoxicology. 2022 May ;90:197-204. Epub 2022 Apr 10. PMID: 35413380

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2018 May 20 ;36(5):336-342. PMID: 29996377

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Pubmed Data : Vopr Pitan. 2016 ;85(5):28-35. PMID: 29381299

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Hesperidin, Rutin

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

Additional Keywords : Antioxidants, Calcium Carbonate, Gene Expression Regulation, Heme oxygenase-1 up-regulation, Hesperidin, Nrf2 activation, Rutin

Problem Substances : Calcium Carbonate

[+]

The flavonoid hesperidin induces synapse formation and improves memory performance.Dec 31, 2016

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Pubmed Data : Front Aging Neurosci. 2017 ;9:184. Epub 2017 Jun 13. PMID: 28659786

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These results show the immunomodulatory actions of hesperidin on the gut-associated lymphoid tissue and reinforce its role as a prebiotic.Feb 01, 2019

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Pubmed Data : Nutrients. 2019 Feb 2 ;11(2). Epub 2019 Feb 2. PMID: 30717392

Article Published Date : Feb 01, 2019

Study Type : Animal Study

Additional Links

Substances : Hesperidin, Prebiotics

Pharmacological Actions : Gastrointestinal Agents, Immunomodulatory

Additional Keywords : Microbiota, Plant Extracts

[+]

These results suggest that hesperidin can prevent exhausting exercise-induced immune alterations.Apr 30, 2020

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Pubmed Data : An Acad Bras Cienc. 2018 Apr 16:0. Epub 2018 Apr 16. PMID: 29668805

Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds.Oct 01, 2005

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Pubmed Data : Antiviral Res. 2005 Oct ;68(1):36-42. PMID: 16115693

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Pubmed Data : Food Chem. 2020 Apr 11 ;326:126785. Epub 2020 Apr 11. PMID: 32438224

Article Published Date : Apr 10, 2020

Study Type : In Vitro Study

Additional Links

Substances : Citrus naringin, Citrus Peel , Hesperidin, neohesperidin

Diseases : Metabolic Syndrome X, Obesity, Oxidative Stress

Pharmacological Actions : Antioxidants, Enzyme Inhibitors: Pancreatic Lipase

[+]

Antiviral zinc oxide nanoparticles mediated by hesperidin and in silico comparison study between antiviral phenolics as anti-SARS-CoV-2.Mar 25, 2021

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Pubmed Data : Colloids Surf B Biointerfaces. 2021 Mar 26 ;203:111724. Epub 2021 Mar 26. PMID: 33838582

Article Published Date : Mar 25, 2021

Study Type : In Vitro Study

Additional Links

Substances : Hesperidin, Zinc

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

[+]

Apigenin and hesperidin augment the toxic effect of doxorubicin against HepG2 cells.May 02, 2019

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Article Published Date : Mar 29, 2021

Study Type : Review

Additional Links

Substances : Biochanin A, Diosmin , EGCG (Epigallocatechin gallate), Epicatechin, Flavonoids, Genistein, Hesperidin, Luteolin, Naringenin , Quercetin, Rutin, Silymarin

Diseases : Coronavirus Infection

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Cytokine Storm

[+]

Flavonoids on diabetic nephropathy: advances and therapeutic opportunities. Aug 06, 2021

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Pubmed Data : Chem Biol Interact. 2019 Apr 4. Epub 2019 Apr 4. PMID: 30954464

Article Published Date : Apr 03, 2019

Study Type : In Vitro Study

Additional Links

Substances : Hesperidin

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Hesperidin inhibits the p53-MDMX interaction-induced apoptosis of non-small-cell lung cancer and enhances the antitumor effect of carboplatin.Dec 31, 2021

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Hesperidin targets Leishmania donovani Sterol C-24 reductase to fight against Leishmaniasis.Mar 29, 2021

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Pubmed Data : Front Public Health. 2020 ;8:600427. Epub 2021 Jan 25. PMID: 33569370

Article Published Date : Dec 31, 2019

Study Type : Review

Additional Links

Substances : Ginger, Hesperidin

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Neuroprotective effects and therapeutic potential of the citrus flavonoid hesperetin in neurodegenerative diseases.May 25, 2022

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Pubmed Data : Pharmaceuticals (Basel). 2022 Mar 21 ;15(3). Epub 2022 Mar 21. PMID: 35337182

Article Published Date : Mar 20, 2022

Study Type : In Vitro Study

Additional Links

Substances : Chlorogenic Acid, Citrus naringin, Ferulic acid, Gallic Acid, Hesperidin, Naringenin , P-Coumaric Acid, Rutin

Diseases : Pseudomonas aeruginosa

Pharmacological Actions : Anti-Bacterial Agents

[+]

Polyphenols in the Mediterranean diet: from dietary sources to microRNA modulation.Feb 22, 2021

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Pubmed Data : Antioxidants (Basel). 2021 Feb 23 ;10(2). Epub 2021 Feb 23. PMID: 33672251

Article Published Date : Feb 22, 2021

Study Type : Review

Additional Links

Substances : Apigenin, Ellagic Acid, Hesperidin, Kaempferol, Naringenin , Oleuropein, Polyphenols

Diseases : Cancers: All

Therapeutic Actions : Dietary Modification: Mediterranean Diet

Pharmacological Actions : Chemotherapeutic, MicroRNA modulator

[+]

Potential therapeutic use of plant flavonoids in Alzheimer's diseaseand Parkinson's disease.Oct 31, 2022

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Pubmed Data : Molecules. 2021 May 26 ;26(11). Epub 2021 May 26. PMID: 34073447

View the Evidence: 291 Abstracts with Hesperidin Research

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8 weeks of 2 S-Hesperidin supplementation improves muscle mass and reduces fat in amateur competitive cyclists.May 10, 2021

8-week supplementation of 2S-hesperidin modulates antioxidant and inflammatory status after exercise until exhaustion in amateur cyclists.Mar 10, 2021

A combination of 500-mg G-hesperidin and 75-mg caffeine for 12 weeks significantly reduced abdominal fat.Dec 31, 2015

A combination of diosmin and hesperidin (Daflon) has been shown to be effective in alleviating (variable degree) haemorrhoidal symptoms and improving the proctoscopic appearance of haemorrhoids.Dec 01, 2004

A combination of diosmin and hesperidin (Daflon) has been shown to be safe and effective in the treatment of all hemorrhoidal symptoms.Dec 01, 2002

A combination of diosmin and hesperidin significantly reduces bleeding in patients with acute internal hemorrhoids. Jun 01, 2005

A micronized purified flavonoid fraction (MPFF) consisting of diosmin and hesperidin significantly improves the symptoms of patients with acute hemorrhoids. - Article 1. Jun 01, 2006

A micronized purified flavonoid fraction (MPFF) consisting of diosmin and hesperidin significantly improves the symptoms of patients with acute hemorrhoids. - Article 2. Jul 01, 2000

Co-administration of flaxseed and hesperidin appears to be superior to either supplementation alone on metabolic syndrome treatment.Apr 14, 2020

Combination therapy of flaxseed and hesperidin enhances the effectiveness of lifestyle modification in cardiovascular risk control in prediabetes.Jan 05, 2021

Daflon, a form of micronized diosmin and hesperidin, improves symptoms of chronic venous insufficiency. Nov 01, 2001

Daflon, a form of micronized diosmin and hesperidin, improves the healing of venous leg ulcers. Sep 01, 2005

Daflon, a form of micronized diosmin and hesperidin, restores pelvic circulation and relieves pelvic symptomatology in women with pelvic pain. Jan 01, 2007

Effect of the consumption of hesperidin in orange juice on the transcriptomic profile of subjects with elevated blood pressure.Nov 30, 2021

Effects of hesperidin consumption on the cardiovascular system in pre- and stage 1 hypertensive subjects.Jul 16, 2021

Flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) in the treatment of I-III degree hemorroidal disease.Oct 31, 2018

Flavonoids (hesperidin) have therapeutic value in the treatment of bleeding bladder varices.Oct 01, 2003

Hesperidin has therapeutic value in the treatment of recurrent aphthous stomatitis. Apr 01, 2006

Hesperidin reduces adverse symptomatic intracerebral hemorrhage.Sep 01, 2019

Hesperidin supplementation accompanied with lifestyle modification is superior to lifestyle modification alone in management of NAFLD.Jun 30, 2019

Hesperidin supplementation can improve metabolic abnormalities and inflammatory status in patients with metabolic syndrome.Dec 15, 2019

Hesperidin-enriched orange juice could be a useful co-adjuvant tool for BP and pulse pressures management in pre- and stage-1 hypertensive individuals.Jul 12, 2020

Reversal of insulin resistance in overweight and obese subjects by trans-resveratrol and hesperetin combination.Jul 10, 2021

Supplementation with an orange extract (2S-hesperdin) 500 mg/day improves estimated FTP and maximum power performance in amateur cyclists.Dec 20, 2020

The combined effect of green tea and α-glucosyl hesperidin in preventing obesity.Jan 23, 2021

The effect of dietary antioxidant supplementation in patients with glaucoma.Dec 31, 2020

The efficacy of flaxseed and hesperidin on non-alcoholic fatty liver disease.Dec 31, 2020

The flavonoids hesperidin and diosmin reduce bleeding and pain after stapled hemorrhoidopexy. Aug 01, 2005

The flavonoids hesperidin and diosmin strengthen capillaries in patients with epistaxis. Mar 01, 1993

These results suggest that hesperidin may have antihypertensive and anti-inflammatory effects in type 2 diabetes.Feb 21, 2018

Hesperidin shielded human keratinocytes from UVB radiation-induced damage and apoptosis.Jan 14, 2016

Hesperidin treatment effectively protected HaCaT keratinocytes from these UVA radiation-induced skin injuries.Nov 30, 2016

The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study Mar 25, 2020

The protective effects of hesperidin and curcumin on 5-fluorouracil-induced nephrotoxicity.Apr 21, 2021

A combination of diosmin and hesperidin (Daflon) improves lymphatic flow indicating its therapeutic role in conditions like perivascular edema. Sep 01, 1995

A combination of diosmin and hesperidin (Detralex) attenuates adjuvant-induced arthritis in rats treated with methotrexate. May 01, 2008

A combination of diosmin and hesperidin is effective in the prevention of intestinal reperfusion injury in an experimental model in rats. Nov 01, 2004

A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury.Dec 31, 2015

A mixture of curcumin, hesperidin and rutin ameliorates hepatic oxidative stress caused by STZ-induced hyperglycemia.Aug 11, 2015

Ameliorative effect of hesperidin against motion sickness.Nov 27, 2019

Ameliorative effects of hesperidin and N-acetylcysteine against formaldehyde-induced-hemato- and genotoxicity.Sep 30, 2021

Antifibrotic activity of hesperidin against dimethylnitrosamine-induced liver fibrosis in rats.May 31, 2014

Antinociceptive synergy between metamizole and hesperidin. Jan 18, 2021

Antiosteoporotic effect of hesperidin against ovariectomy-induced osteoporosis.May 23, 2021

Based on activation of p62-Keap1-Nrf2 pathway, hesperidin protects arsenic-trioxide-induced cardiotoxicity.Dec 31, 2020

Bee venom plus hesperidin particularly seemed to be the most potent in improving rheumatoid arthritis in Wistar rats.May 31, 2018

Beta-Cryptoxanthin and Hesperidin are potential cancer chemopreventive agents against tongue, colon, and lung cancers. Jan 01, 2012

Both hesperidin and thymol were effective in suppressing allergic symptoms and inflammation in the treatment of allergic rhinitis.Nov 27, 2018

Citrus flavanones prevent systemic inflammation and ameliorate oxidative stress.Jun 14, 2016

Combined treatment with naringenin and hesperetin might be a promising anti-cancer strategy for pancreatic cancers.Nov 19, 2018

Consumption of foods enriched with flavonoid fractions of diosmin and hesperidin may be beneficial for individuals inhabiting lead-polluted environments.Sep 30, 2021

Curcumin, beta-carontein and hesperidin prevent chemically-induced oral cancer.Sep 01, 1994

Dietary hesperidin suppresses lipopolysaccharide-induced inflammation in male mice.Dec 31, 2021

Diosmin and hesperidin may have protective effects against radiation-induced acute proctitis.Mar 31, 2011

Effect of hesperidin treatment on α-Klotho/FGF-23 pathway in rats with experimentally-induced diabetes.Dec 31, 2018

Effects in vitro and in vivo of hesperidin administration in an experimental model of acute lung inflammation.Jan 19, 2022

Egyptian sweet orange hesperidin ameliorates the cytotoxic effect of doxorubicin while enhancing its anti-tumor effect.Mar 31, 2018

Four citrus flavanones exert atherosclerosis alleviation effects.May 04, 2021

Gallic and hesperidin ameliorate electrolyte imbalances in AlCl3-induced nephrotoxicity.Dec 31, 2021

Hesperetin attenuates testicular damage in diabetic rats.Sep 30, 2018

Hesperetin confers neuroprotection by regulating Nrf2/TLR4/NF-κB signaling in an Aβ mouse model.Feb 11, 2019

Hesperetin may be a potential novel therapeutic candidate for protection against ventilator-induced acute lung injury.Dec 14, 2015

Hesperetin possesses a potential chemopreventive activity against Benzo[a]pyrene induced lung cancer.Dec 04, 2015

Hesperetin prevents bone resorption by inhibiting RANKL-induced osteoclastogenesis.Dec 31, 2017

Hesperetin promotes cisplatin-induced apoptosis of gastric cancer.Dec 31, 2019

Hesperetin protects against cisplatin-induced ototoxicity in a animal model.May 31, 2016

Hesperetin treatment leads to a decrease in oxidative stress, and associated histological damage.Dec 31, 2015

Hesperidin a flavanoglycone protects against gamma-irradiation induced liver damage and oxidative stress in rats.Jun 10, 2008

Hesperidin a positive immunomodulatory effect in a clinically relevant model of Acute Respiratory Distress Syndrome.Apr 24, 2007

Hesperidin accelerates the gastric healing process of acetic acid-induced ulcer.May 12, 2019

Hesperidin administration could have significant therapeutic value for the prevention and clinical treatment of psoriasis.Feb 14, 2019

Hesperidin alleviated inflammation and oxidative stress responses in cigarette smoke-induced COPD.Mar 12, 2020

Hesperidin

View the Evidence:
291 Abstracts with Hesperidin Research