Hesperidin

Name	AC	CK
Hemorrhoids	8	71
Hypertension	9	67
Oxidative Stress	31	67
Inflammation	17	44
Obesity	8	36
Athletic Performance	4	32
Rheumatoid Arthritis	6	29
Diabetes Mellitus: Type 2	5	28
Nonalcoholic fatty liver disease (NAFLD)	6	26
Cardiovascular Diseases	3	24
Insulin Resistance	5	23
Metabolic Syndrome X	4	23
Cardiovascular Disease	1	21
Liver Cancer	9	15
Aluminum Toxicity	7	14
Chemically-Induced Liver Damage	8	14
Depression	7	14
Kidney Damage: Chemically-Induced	8	14
Alzheimer's Disease	9	13
Coronavirus Infection	13	13
Diabetic Complications	7	12
Dyslipidemias	2	12
Exercise-Induced Tissue Damage	2	12
Chemotherapy-Induced Toxicity: Cisplatin	5	11
Chronic Venous Insufficency	2	11
Glaucoma	2	11
Testicular Injury: Chemical/Metal Induced	6	11
Venous Ulcer	2	11
Aphthous Ulcer	1	10
Bladder Degeneration	1	10
Brain Inflammation	5	10
Breast Cancer	8	10
Cerebral Hemorrhage	1	10
Chronic Pelvic Pain Syndrome	1	10
Dental Caries	1	10
Diabetes Mellitus: Type 2: Prevention	1	10
Epistaxis	1	10
Hematuria	1	10
Leg Ulcer	1	10
Lipid Peroxidation	5	10
Metabolic Diseases	1	10
Nose Bleed	1	10
Osteoporosis	6	10
Parkinson's Disease	6	10
Pelvic Inflammatory Disease	1	10
Postoperative Recovery	1	10
Prediabetes	1	10
Prehypertension	1	10
Primary Sclerosing Cholangitis	1	10
Stroke: Ischemic	1	10
Ultraviolet Radiation Induced Damage	2	10
Vericose Veins: Bladder	1	10
Neurodegenerative Diseases	7	9
Drug Toxicity: Methotrexate	4	8
Ischemia	4	8
Pesticide Toxicity	4	8
Radiation Induced Illness	5	8
Atherosclerosis	4	7
Cancers: All	6	7
Chemotherapy-Induced Toxicity: Cyclophosphamide	4	7
Oral Cancer	3	7
Alcohol Toxicity	3	6
Brain: Oxidative Stress	3	6
Chemotherapy-Induced Toxicity: Paclitaxel	3	6
Fluoride Toxicity	3	6
Gastric Ulcer	3	6
Hyperglycemia	4	6
Hypothyroidism	3	6
Lipopolysaccharide-Induced Toxicity	4	6
Osteoarthritis	4	6
Chemotherapy and Radiation Toxicity	3	5
Memory Disorders	3	5
Arthritis	2	4
Chemotherapy-Induced Toxicity: Doxorubicin	2	4
Colon Cancer	2	4
DNA damage	2	4
Diabetes Mellitus: Type 1	2	4
Diabetic Ulcer	2	4
Ehrlich carcinoma	2	4
Hyperlipidemia	2	4
Kidney Damage	2	4
Liver Damage	2	4
Liver Damage: Drug-Induced	2	4
Lung Inflammation	2	4
Myocardial Ischemia	2	4
Pseudomonas aeruginosa	3	4
Pulmonary Fibrosis: Bleomycin-Induced	2	4
Radiation	3	4
Sepsis	2	4
Tongue Cancer	2	4
Wound Healing	3	4
C-Reactive Protein	2	3
Colitis	2	3
Coronavirus Disease (Covid-19)	3	3
Diabetic Nephropathy	2	3
Diabetic Retinopathy	3	3
Hydrogen Peroxide Induced Toxicity	2	3
Influenza A	2	3
Kidney Cancer	2	3
Lung Cancer	2	3
Multiple Sclerosis	2	3
Pancreatitis	2	3
Periodontitis	2	3
Skin Cancer	2	3
Acrylamide-induced toxicity	1	2
Acute Respiratory Distress Syndrome	1	2
Advanced Glycation End products (AGE)	1	2
Aging: Brain	1	2
Allergic Rhinitis	1	2
Anxiety	1	2
Arterial Hardening: Elasticity	1	2
Arthritis: Rheumatoid	1	2
Aspirin-Induced Toxicity	1	2
Benzo[a]pyrene-induced Toxicity	1	2
Brain Injury: Traumatic	1	2
Breast Cancer: Triple Negative	2	2
Bronchiolitis	1	2
Cancers: Drug Resistant	1	2
Cardiac Hypertrophy	1	2
Cardiomyopathy	1	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Chemotherapy-Induced Toxicity: Arsenic Trioxide	1	2
Chemotherapy-Induced Toxicity: Peripheral Neuropathy	1	2
Chronic Obstructive Pulmonary Disease	1	2
Chronic Pain	1	2
Cognitive Decline/Dysfunction	1	2
Constipation	1	2
Diabetes: Cognitive Dysfunction	1	2
Diabetic Neuropathy	1	2
Endometriosis	1	2
Endothelial Dysfunction	1	2
Epilepsy	1	2
Epilepsy: Drug-Induced	1	2
Fatty Liver	1	2
Formaldehyde Toxicity	1	2
Gastric Cancer	1	2
Gastrointestinal Complaints	1	2
Gastrointestinal Inflammation	1	2
Gastrointestinal Surgical Procedures	1	2
Gout	1	2
Hepatic Encephalopathy	1	2
Hepatic Steatosis	1	2
High Fat Diet	1	2
Hyperthyroidism	1	2
Hyperuricemia	1	2
Infertility: Male	1	2
Intestinal Ischemia	1	2
Iron Overload	1	2
Keratitis	1	2
Kidney Damage: Drug-Induced	1	2
Lead Poisoning	1	2
Liver Cirrhosis	1	2
Liver Disease	1	2
Liver Fibrosis	1	2
Liver Injury: Ischemia/reperfusion	1	2
Liver: Fatty	1	2
Low Immune Function: Exercise-Induced	1	2
Lung Cancer: Prevention	1	2
Lung Damage	1	2
Lung Injury: Smoke-Induced	1	2
Lymphatic Diseases	1	2
Lymphatic Stasis	1	2
Lymphedema	1	2
Melanoma	1	2
Motion Sickness	1	2
Mycotoxin Toxicity	1	2
Neuropathic Pain	1	2
Osteosarcoma	1	2
Otitis media	1	2
Pancreatic Cancer	1	2
Petroleum Exposure And Toxicity	1	2
Pleurisy	1	2
Post-Traumatic Stress Disorders (PTSD)	1	2
Pre-Eclampsia	1	2
Prenatal Chemical Exposures	1	2
Proctitis	1	2
Prostate Cancer	2	2
Prostatic Hyperplasia: Benign	1	2
Psoriasis	1	2
Radiotherapy	1	2
Sarcopenia	1	2
Spinal Cord Injuries	1	2
Squamous cell carcinoma	1	2
Subarachnoid hemorrhage	1	2
Sugar (Sucrose) Toxicity	1	2
Ulcerative Colitis	1	2
Ulcers	1	2
Vaccine-induced Toxicity	1	2
Varicocele	1	2
Acute Myeloid Leukemia	1	1
Adiponectin: Low Levels	1	1
Aging	1	1
Allergic Airway Diseases	1	1
Amyotrophic Lateral Sclerosis	1	1
Amyotrophic lateral sclerosis (ALS)	1	1
Animal Diseases: Canine Distemper Virus	1	1
Arsenic Poisoning	1	1
Asthma	1	1
Bacillus Cereus infection	1	1
Bisphenol Toxicity	1	1
Burns	1	1
Cancer Metastasis	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Cartilage Diseases	1	1
Central Nervous System Diseases	1	1
Chikungunya Virus	1	1
Cholangiocarcinoma	1	1
Dengue	1	1
Diabetes: Oxidative Stress	1	1
Escherichia coli Infections	1	1
Gallbladder Cancer	1	1
Glioma	1	1
HIV Infections	1	1
Helicobacter Pylori Infection	1	1
Hepatitis C	1	1
Hypoglycemia	1	1
Influenza	1	1
Leishmaniasis	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Liver Cancer: Prevention	1	1
Mitochondrial Dysfunction	1	1
Neuroblastoma	1	1
Neutropenia	1	1
Neutropenia: Chemotherapy Induced	1	1
Non-Small-Cell Lung Carcinoma	1	1
Periodontal Diseases	1	1
Promyelocytic leukemia	1	1
Pulmonary Fibrosis	1	1
Staphylococcus aureus infection	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Surgery: Anesthesiology	1	1
Zika Virus	1	1

Name	AC	CK
Anti-Inflammatory Agents	108	270
Antioxidants	102	220
Tumor Necrosis Factor (TNF) Alpha Inhibitor	39	95
Hypolipidemic	14	75
Cardioprotective	13	72
Antihypertensive Agents	7	65
Hepatoprotective	26	64
Hypoglycemic Agents	12	63
Neuroprotective Agents	34	63
Anti-Apoptotic	24	47
Interleukin-1 beta downregulation	23	43
NF-kappaB Inhibitor	19	41
Interleukin-6 Downregulation	23	37
Nrf2 activation	15	35
Renoprotective	19	34
Chemoprotective Agents	13	27
Antiproliferative	16	24
Chemopreventive	13	22
Insulin Sensitizers	3	21
Apoptotic	16	20
Radioprotective	12	20
Antiviral Agents	19	19
Anticarcinogenic Agents	10	17
Matrix metalloproteinase-9 (MMP-9) inhibitor	6	16
Antidepressive Agents	7	14
Superoxide Dismutase Up-regulation	7	14
Transforming growth factor beta (TGF-β) inhibitor	3	13
Cyclooxygenase 2 Inhibitors	7	12
Chemosensitizer	7	11
Immunomodulatory	7	11
Malondialdehyde Down-regulation	6	11
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	11
Analgesics	1	10
Anti-metastatic	8	10
Heme oxygenase-1 up-regulation	6	10
Photoprotective	2	10
Gastroprotective	5	9
Anti-Ulcer Agents	4	8
Chemotherapeutic	6	7
Osteoprotective	4	7
Cell cycle arrest	5	6
Gastrointestinal Agents	3	6
Anti-Fibrotic	3	5
Interleukin-4 downregulation	3	5
MicroRNA modulator	4	5
Nitric Oxide Inhibitor	3	5
Prophylactic Agents	4	5
Angiogenesis Inducing Agents	2	4
Anti-Bacterial Agents	4	4
Autophagy Inhibitors	2	4
Brain-derived neurotrophic factor modulator	2	4
Catalase Up-Regulation	2	4
Genoprotective	2	4
Neurogenesis	2	4
Pancreato Protective Agents	3	4
Postaglandin PGE2 downregulation	2	4
Vascular Endothelial Growth Factor Inhibitors	2	4
Bcl-2 protein down-regulation	2	3
Heat Shock Protein Down-Regulation	2	3
Interleukin-10 downregulation	2	3
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	2	3
SIRT1 Activator	2	3
Tumor Suppressor Protein p53 Upregulation	2	3
Alpha-glucosidase inhibitor	2	2
Angiogenesis Inhibitors	1	2
Anti-Angiogenic	1	2
Anti-Anxiety Agents	1	2
Anti-Glycation Agents	1	2
Anti-atherogenic	1	2
Anticonvulsants	1	2
Antinoceceptive	1	2
Cytoprotective	1	2
Dermatologic Agents	1	2
Fertility Agents: Male	1	2
Glutathione Upregulation	1	2
Histamine up-regulation	1	2
Laxative	1	2
Lymphagogue	1	2
Nitric Oxide Enhancer	1	2
Tumor Necrosis Factor (TNF) Alpha Enhancer	1	2
Vascular Endothelial Growth Factor C Inhibitor	1	2
Vascular Endothelial Growth Factor Regulator	1	2
Vasodilator Agents	1	2
Wnt/β-catenin signaling pathway modulation	1	2
Acetylcholinesterase Inhibitor	1	1
Alpha-amylase inhibitor	1	1
Angiotensin-Converting Enzyme Inhibitors	1	1
Anti-Asthmatic Agents	1	1
C-Jun N-Terminal Kinases (JNK) Modulator	1	1
Chondroprotective	1	1
Enzyme Inhibitors	1	1
Enzyme Inhibitors: Pancreatic Lipase	1	1
Expectorants	1	1
Extracellular Signal-Regulated Kinases Modulator	1	1
Inhibitor of Nuclear Factor Kappa-B Kinase (IKK)	1	1
Interferon Gamma Reducer	1	1
Interleukin-5 downregulation	1	1
Interleukin-8 downregulation	1	1
Leishmanicidal	1	1
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	1
NF-kappa-B-inducing kinase (NIK) modulator	1	1
Neurominidase Inhibitor	1	1
P21 Activation	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
Prostaglandin PGE2 downregulation	1	1
Protease Inhibitors	1	1
STAT3 Inhibitor	1	1

[+]

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Pubmed Data : Food Funct. 2021 May 11 ;12(9):3872-3882. PMID: 33977947

Article Published Date : May 10, 2021

Study Type : Human Study

Additional Links

Substances : Hesperidin

Diseases : Athletic Performance

Therapeutic Actions : Exercise: Cycling

[+]

8-week supplementation of 2S-hesperidin modulates antioxidant and inflammatory status after exercise until exhaustion in amateur cyclists.Mar 10, 2021

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Pubmed Data : Antioxidants (Basel). 2021 Mar 11 ;10(3). Epub 2021 Mar 11. PMID: 33799833

Article Published Date : Mar 10, 2021

Study Type : Human Study

Additional Links

Substances : Hesperidin

Diseases : Exercise-Induced Tissue Damage, Inflammation, Oxidative Stress

Therapeutic Actions : Exercise: Cycling

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

A combination of 500-mg G-hesperidin and 75-mg caffeine for 12 weeks significantly reduced abdominal fat.Dec 31, 2015

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Pubmed Data : Nutr J. 2016 ;15(1):6. Epub 2016 Jan 19. PMID: 26786000

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Pubmed Data : Mol Nutr Food Res. 2021 Jul 17:e2001175. Epub 2021 Jul 17. PMID: 34272817

Article Published Date : Jul 16, 2021

Study Type : Human Study

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Substances : Hesperidin

Diseases : Hypertension

Pharmacological Actions : Antihypertensive Agents

[+]

Effects of hesperidin supplementation on cardiometabolic markers.Jul 21, 2024

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Pubmed Data : Nutr Rev. 2024 Jul 22. Epub 2024 Jul 22. PMID: 39038797

Propolis and hesperidin agents showed promising effects in terms of remineralization of carious dental tissue and hindering the progression of caries.Dec 31, 2022

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Pubmed Data : Sci Rep. 2021 09 24 ;11(1):19067. Epub 2021 Sep 24. PMID: 34561541

Article Published Date : Jan 23, 2021

Study Type : Human Study

Additional Links

Substances : Green Tea, Hesperidin

Diseases : Obesity

Therapeutic Actions : Placebo Effect

Additional Keywords : Anti-Obesity Agents

[+]

The effect of dietary antioxidant supplementation in patients with glaucoma.Dec 31, 2020

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Pubmed Data : Acta Chir Belg. 2004 Nov-Dec;104(6):715-8. PMID: 15663281

Article Published Date : Nov 01, 2004

Study Type : Animal Study

Additional Links

Substances : Diosmin , Hesperidin

Diseases : Gastrointestinal Surgical Procedures

[+]

A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury.Dec 31, 2015

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Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2014 Jun ;387(6):559-67. Epub 2014 Mar 14. PMID: 24627177

Article Published Date : May 31, 2014

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Liver Cirrhosis, Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic

[+]

Antinociceptive synergy between metamizole and hesperidin. Jan 18, 2021

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Pubmed Data : Arch Med Res. 2021 Jan 19. Epub 2021 Jan 19. PMID: 33483148

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Pubmed Data : Phytomedicine. 2018 Nov 20 ;58:152762. Epub 2018 Nov 20. PMID: 31005717

Article Published Date : Nov 19, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Hesperidin, Naringenin

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Selective Antiproliferation

[+]

Consumption of foods enriched with flavonoid fractions of diosmin and hesperidin may be beneficial for individuals inhabiting lead-polluted environments.Sep 30, 2021

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Pubmed Data : Toxicol Res. 2021 Oct ;37(4):473-484. Epub 2021 Apr 29. PMID: 34631504

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Pubmed Data : J Cancer Res Ther. 2011 Apr-Jun;7(2):152-6. PMID: 21768702

Article Published Date : Mar 31, 2011

Study Type : Animal Study

Additional Links

Substances : Diosmin , Hesperidin

Diseases : Chemotherapy and Radiation Toxicity, Proctitis

Pharmacological Actions : Radioprotective

[+]

Effect of hesperidin in the prevention of aluminum chloride-induced testicular dysfunction.Dec 31, 2023

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Pubmed Data : Mol Pharm. 2024 Jun 3 ;21(6):3061-3076. Epub 2024 May 17. PMID: 38757678

Article Published Date : Jun 02, 2024

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Melanoma

Pharmacological Actions : Anti-metastatic, Chemotherapeutic

[+]

Four citrus flavanones exert atherosclerosis alleviation effects.May 04, 2021

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Pubmed Data : J Agric Food Chem. 2021 May 5 ;69(17):5226-5237. Epub 2021 Apr 23. PMID: 33890787

Article Published Date : May 04, 2021

Study Type : Animal Study

Additional Links

Substances : Citrus naringin, Flavonoids, Hesperidin, Naringenin

Diseases : Atherosclerosis

Pharmacological Actions : Anti-atherogenic

[+]

Gallic and hesperidin ameliorate electrolyte imbalances in AlCl3-induced nephrotoxicity.Dec 31, 2021

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Pubmed Data : Biochem Res Int. 2022 ;2022:6151684. Epub 2022 Oct 10. PMID: 36263197

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Pubmed Data : Front Pharmacol. 2018 ;9:1028. Epub 2018 Sep 11. PMID: 30254586

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

[+]

Hesperetin promotes cisplatin-induced apoptosis of gastric cancer.Dec 31, 2019

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Pubmed Data : Biomed Pharmacother. 2023 Apr ;160:114389. Epub 2023 Feb 13. PMID: 36791565

Article Published Date : Mar 31, 2023

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Prostatic Hyperplasia: Benign

Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Transforming growth factor beta (TGF-β) inhibitor

[+]

Hesperidin ameliorates bleomycin-induced experimental pulmonary fibrosis.Dec 31, 2018

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Pubmed Data : Cells. 2023 Aug 7 ;12(15). Epub 2023 Aug 7. PMID: 37566094

Article Published Date : Aug 06, 2023

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Sarcopenia

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Hesperidin and capsaicin prevent hepatic steatosis and other metabolic syndrome-related alterations in western diet-fed rats.Oct 09, 2018

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Pubmed Data : Sci Rep. 2018 Oct 10 ;8(1):15100. Epub 2018 Oct 10. PMID: 30305645

Article Published Date : Oct 09, 2018

Study Type : Animal Study

Additional Links

Substances : Capsaicin, Hesperidin

Diseases : Hepatic Steatosis, Obesity

Pharmacological Actions : Hepatoprotective, Hypolipidemic

Anti Therapeutic Actions : Western Diet

[+]

Hesperidin and chrysin alleviated the renal injury induced by colistin via anti-oxidant and anti-inflammatory activities.Nov 30, 2018

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Pubmed Data : Tumour Biol. 2015 Jun 23. Epub 2015 Jun 23. PMID: 26099723

Article Published Date : Jun 22, 2015

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Cancers: Drug Resistant, Ehrlich carcinoma

Pharmacological Actions : Vascular Endothelial Growth Factor Inhibitors

Problem Substances : Doxorubicin

[+]

Hesperidin attenuated apoptotic-related genes in testicle of a male rat model of varicocoele.Dec 31, 2019

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Pubmed Data : Andrology. 2020 Jan ;8(1):249-258. Epub 2019 Jul 19. PMID: 31325243

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Pubmed Data : Exp Toxicol Pathol. 2017 Jan 26. Epub 2017 Jan 26. PMID: 28132802

Article Published Date : Jan 25, 2017

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Diabetes Mellitus: Type 1, Osteoporosis

Pharmacological Actions : Osteoprotective , Prophylactic Agents

Additional Keywords : Risk Reduction

[+]

Hesperidin could be used to enhance wound healing in chronic diabetic foot ulcers.Dec 31, 2017

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Pubmed Data : FEBS Open Bio. 2023 Mar ;13(3):532-544. Epub 2023 Feb 7. PMID: 36700348

Article Published Date : Feb 28, 2023

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Gastrointestinal Complaints

Pharmacological Actions : Gastroprotective

[+]

Hesperidin exhibits in vitro and in vivo antitumor effects in human osteosarcoma MG-63 cells and xenograft mice models.Oct 31, 2018

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Pubmed Data : Exp Gerontol. 2023 Feb ;172:112064. Epub 2022 Dec 15. PMID: 36528304

Article Published Date : Jan 31, 2023

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Diabetic Neuropathy, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, SIRT1 Activator

[+]

Hesperidin inhibits tobacco smoke-induced pulmonary cell proliferation and EMT in mouse lung tissues.Dec 31, 2022

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Hesperidin protects against cisplatin-induced cardiotoxicity.Mar 23, 2022

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Pubmed Data : Chem Biol Interact. 2018 Jun 23 ;291:153-161. Epub 2018 Jun 23. PMID: 29944876

Article Published Date : Jun 22, 2018

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Diabetic Ulcer, Gastric Ulcer

Pharmacological Actions : Anti-Inflammatory Agents, Anti-Ulcer Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Nrf2 activation

Additional Keywords : Natural Substances Versus Drugs

[+]

Hesperidin protects against the chlorpyrifos-induced chronic hepato-renal toxicity.Apr 27, 2021

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Pubmed Data : Environ Toxicol. 2021 Apr 28. Epub 2021 Apr 28. PMID: 33908150

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Pubmed Data : Biomed Pharmacother. 2016 Oct ;83:718-724. Epub 2016 Jul 29. PMID: 27470573

Article Published Date : Sep 30, 2016

Study Type : Animal Study

Additional Links

Substances : Hesperidin, Nuts

Diseases : Breast Cancer, Kidney Cancer, Liver Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

[+]

Hesperidin reduces the effects of ischemia/reperfusion injury damage.Sep 30, 2016

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Pubmed Data : J Cell Mol Med. 2023 Sep ;27(18):2756-2769. Epub 2023 Aug 15. PMID: 37581480

Article Published Date : May 31, 2021

Study Type : Animal Study

Additional Links

Substances : Hesperidin, Lemon

Diseases : Arthritis, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Hesperidin/chitosan nanogel mitigates apoptosis and endoplasmic reticulum stress in fluoride and aluminum-induced testicular injury.Dec 12, 2023

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Pubmed Data : Biol Trace Elem Res. 2023 Dec 13. Epub 2023 Dec 13. PMID: 38087036

Article Published Date : Dec 12, 2023

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Aluminum Toxicity , Fluoride Toxicity , Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Anti-Apoptotic, Antioxidants

Problem Substances : Aluminum, Sodium Fluoride

[+]

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Pubmed Data : Oxid Med Cell Longev. 2021 ;2021:9990091. Epub 2021 Aug 11. PMID: 34422219

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Citrus naringin, Hesperidin

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Diclofenac

[+]

Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity.Apr 30, 2022

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Pubmed Data : Neurotoxicology. 2022 May ;90:197-204. Epub 2022 Apr 10. PMID: 35413380

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Pubmed Data : Food Funct. 2024 Feb 5 ;15(3):1460-1475. Epub 2024 Feb 5. PMID: 38226659

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Pubmed Data : Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2018 May 20 ;36(5):336-342. PMID: 29996377

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Pubmed Data : Vopr Pitan. 2016 ;85(5):28-35. PMID: 29381299

Article Published Date : Dec 31, 2015

Study Type : Animal Study

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Substances : Hesperidin, Rutin

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

Additional Keywords : Antioxidants, Calcium Carbonate, Gene Expression Regulation, Heme oxygenase-1 up-regulation, Hesperidin, Nrf2 activation, Rutin

Problem Substances : Calcium Carbonate

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The flavonoid hesperidin induces synapse formation and improves memory performance.Dec 31, 2016

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Pubmed Data : Front Aging Neurosci. 2017 ;9:184. Epub 2017 Jun 13. PMID: 28659786

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Pubmed Data : Nutrients. 2019 Feb 2 ;11(2). Epub 2019 Feb 2. PMID: 30717392

Article Published Date : Feb 01, 2019

Study Type : Animal Study

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Substances : Hesperidin, Prebiotics

Pharmacological Actions : Gastrointestinal Agents, Immunomodulatory

Additional Keywords : Microbiota, Plant Extracts

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These results suggest that hesperidin can prevent exhausting exercise-induced immune alterations.Apr 30, 2020

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Pubmed Data : An Acad Bras Cienc. 2018 Apr 16:0. Epub 2018 Apr 16. PMID: 29668805

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Pubmed Data : Drug Des Devel Ther. 2019 ;13:3855-3866. Epub 2019 Nov 12. PMID: 32009777

Article Published Date : Dec 31, 2018

Study Type : Review

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Substances : Hesperidin

Diseases : Hyperglycemia, Obesity

Pharmacological Actions : Hypoglycemic Agents

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A review of the benefits of hesperidin in central nervous system disorders.Nov 30, 2019

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Pubmed Data : J Vet Sci. 2022 Jan ;23(1):e4. PMID: 35088951

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

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Substances : Flavonoids, Hesperidin, Nobiletin , Tangeretin

Diseases : Obesity

Pharmacological Actions : Hypolipidemic

Additional Keywords : Anti-Obesity Agents

[+]

Anti-inflammatory effect of hesperidin enhances chondrogenesis of human mesenchymal stem cells for cartilage tissue repair.Dec 31, 2017

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Pubmed Data : J Inflamm (Lond). 2018 ;15:14. Epub 2018 Jul 20. PMID: 30038551

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Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2021 Aug 31 ;67(2):178-186. Epub 2021 Aug 31. PMID: 34817319

Article Published Date : Aug 30, 2021

Study Type : In Vitro Study

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Substances : Citrus naringin, Hesperidin, Naringenin , Nobiletin , Tangeretin

Diseases : Cancer Metastasis, Cancers: All

Pharmacological Actions : Anti-metastatic

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Antioxidant and anti-inflammatory effects of citrus flavonoid hesperetin.Jul 09, 2020

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Pubmed Data : BMC Pharmacol Toxicol. 2019 May 3 ;20(1):22. Epub 2019 May 3. PMID: 31053173

Article Published Date : May 02, 2019

Study Type : In Vitro Study

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Substances : Apigenin, Hesperidin

Diseases : Liver Cancer

Pharmacological Actions : Chemosensitizer, Chemotherapeutic

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

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Apigenin and hesperidin downregulate DNA repair genes in MCF-7 breast cancer cells and augment doxorubicin toxicity. Sep 25, 2020

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Pubmed Data : Molecules. 2020 Sep 26 ;25(19). Epub 2020 Sep 26. PMID: 32993087

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Pubmed Data : Biosci Biotechnol Biochem. 2019 Apr 24:1-9. Epub 2019 Apr 24. PMID: 31017523

Article Published Date : Apr 23, 2019

Study Type : In Vitro Study

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Substances : Citrus Peel , Flavonoids, Hesperidin, Nobiletin , Tangeretin

Pharmacological Actions : Hypolipidemic, MicroRNA modulator

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Co-delivery of hesperidin and clarithromycin in a nanostructured lipid carrier for the eradication of Helicobacter pylori.Apr 06, 2021

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Pubmed Data : Bioorg Chem. 2021 Apr 7 ;112:104896. Epub 2021 Apr 7. PMID: 33901764

Article Published Date : Apr 06, 2021

Study Type : In Vitro Study

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Substances : Hesperidin

Diseases : Helicobacter Pylori Infection

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Effects of hesperidin on the histological structure, oxidative stress, and apoptosis in the liver and kidney induced by NiCl2.Dec 31, 2023

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Pubmed Data : Diabetol Metab Syndr. 2021 Apr 29 ;13(1):50. Epub 2021 Apr 29. PMID: 33926520

Article Published Date : Apr 28, 2021

Study Type : In Vitro Study

Additional Links

Substances : Hesperidin

Diseases : Insulin Resistance, Mitochondrial Dysfunction

Pharmacological Actions : Antioxidants, Insulin Sensitizers, MicroRNA modulator

[+]

Hesperidin ameliorates dexamethasone-induced osteoporosis by inhibiting p53.Dec 31, 2021

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Pubmed Data : Front Cell Dev Biol. 2022 ;10:820922. Epub 2022 Apr 11. PMID: 35478958

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Hesperidin

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

Problem Substances : Dexamethasone

[+]

Hesperidin ameliorates H2O2-induced bovine mammary epithelial cell oxidative stress.Apr 08, 2024

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Pubmed Data : Life (Basel). 2021 Sep 10 ;11(9). Epub 2021 Sep 10. PMID: 34575098

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Pubmed Data : J Cancer Res Ther. 2015 Apr-Jun;11(2):352-7. PMID: 26148599

Article Published Date : Mar 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Hesperidin, Silibinin

Diseases : Acute Myeloid Leukemia

Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic

Additional Keywords : Dose Response, Drug: Cytarabine, Natural Substance/Drug Synergy

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View the Evidence: 358 Abstracts with Hesperidin Research

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Hesperidin administration could benefit patients with CVD by reducing LDL, TC, and TG.Mar 09, 2024

Hesperidin reduces systolic blood pressure in diabetic patients.Jun 30, 2024

The effects of hesperidin supplementation on cardiovascular risk factors in adults.Dec 31, 2022

Efficacy and safety of dietary polyphenols in rheumatoid arthritis.Dec 31, 2022

8 weeks of 2 S-hesperidin prevents a decrease in p O2 at submaximal intensity in amateur cyclists in off-season.Mar 19, 2023

8 weeks of 2 S-Hesperidin supplementation improves muscle mass and reduces fat in amateur competitive cyclists.May 10, 2021

8-week supplementation of 2S-hesperidin modulates antioxidant and inflammatory status after exercise until exhaustion in amateur cyclists.Mar 10, 2021

A combination of 500-mg G-hesperidin and 75-mg caffeine for 12 weeks significantly reduced abdominal fat.Dec 31, 2015

A combination of diosmin and hesperidin (Daflon) has been shown to be effective in alleviating (variable degree) haemorrhoidal symptoms and improving the proctoscopic appearance of haemorrhoids.Dec 01, 2004

A combination of diosmin and hesperidin (Daflon) has been shown to be safe and effective in the treatment of all hemorrhoidal symptoms.Dec 01, 2002

A combination of diosmin and hesperidin significantly reduces bleeding in patients with acute internal hemorrhoids. Jun 01, 2005

A micronized purified flavonoid fraction (MPFF) consisting of diosmin and hesperidin significantly improves the symptoms of patients with acute hemorrhoids. - Article 1. Jun 01, 2006

A micronized purified flavonoid fraction (MPFF) consisting of diosmin and hesperidin significantly improves the symptoms of patients with acute hemorrhoids. - Article 2. Jul 01, 2000

Benefit of glucosyl Hesperidin in patients with primary biliary cholangitis.Dec 01, 2022

Co-administration of flaxseed and hesperidin appears to be superior to either supplementation alone on metabolic syndrome treatment.Apr 14, 2020

Combination therapy of flaxseed and hesperidin enhances the effectiveness of lifestyle modification in cardiovascular risk control in prediabetes.Jan 05, 2021

Daflon, a form of micronized diosmin and hesperidin, improves symptoms of chronic venous insufficiency. Nov 01, 2001

Daflon, a form of micronized diosmin and hesperidin, improves the healing of venous leg ulcers. Sep 01, 2005

Daflon, a form of micronized diosmin and hesperidin, restores pelvic circulation and relieves pelvic symptomatology in women with pelvic pain. Jan 01, 2007

Effect of the consumption of hesperidin in orange juice on the transcriptomic profile of subjects with elevated blood pressure.Nov 30, 2021

Effects of hesperidin consumption on the cardiovascular system in pre- and stage 1 hypertensive subjects.Jul 16, 2021

Effects of hesperidin supplementation on cardiometabolic markers.Jul 21, 2024

Flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) in the treatment of I-III degree hemorroidal disease.Oct 31, 2018

Flavonoids (hesperidin) have therapeutic value in the treatment of bleeding bladder varices.Oct 01, 2003

Hesperidin has therapeutic value in the treatment of recurrent aphthous stomatitis. Apr 01, 2006

Hesperidin reduces adverse symptomatic intracerebral hemorrhage.Sep 01, 2019

Hesperidin supplementation accompanied with lifestyle modification is superior to lifestyle modification alone in management of NAFLD.Jun 30, 2019

Hesperidin supplementation can improve metabolic abnormalities and inflammatory status in patients with metabolic syndrome.Dec 15, 2019

Hesperidin-enriched orange juice could be a useful co-adjuvant tool for BP and pulse pressures management in pre- and stage-1 hypertensive individuals.Jul 12, 2020

Propolis and hesperidin agents showed promising effects in terms of remineralization of carious dental tissue and hindering the progression of caries.Dec 31, 2022

Reversal of insulin resistance in overweight and obese subjects by trans-resveratrol and hesperetin combination.Jul 10, 2021

Supplementation with an orange extract (2S-hesperdin) 500 mg/day improves estimated FTP and maximum power performance in amateur cyclists.Dec 20, 2020

The combined effect of green tea and α-glucosyl hesperidin in preventing obesity.Jan 23, 2021

The effect of dietary antioxidant supplementation in patients with glaucoma.Dec 31, 2020

The efficacy of flaxseed and hesperidin on non-alcoholic fatty liver disease.Dec 31, 2020

The flavonoids hesperidin and diosmin reduce bleeding and pain after stapled hemorrhoidopexy. Aug 01, 2005

The flavonoids hesperidin and diosmin strengthen capillaries in patients with epistaxis. Mar 01, 1993

These results suggest that hesperidin may have antihypertensive and anti-inflammatory effects in type 2 diabetes.Feb 21, 2018

Hesperidin shielded human keratinocytes from UVB radiation-induced damage and apoptosis.Jan 14, 2016

Hesperidin treatment effectively protected HaCaT keratinocytes from these UVA radiation-induced skin injuries.Nov 30, 2016

Hesperidin activates Nrf2 to protect cochlear hair cells from cisplatin-induced damage.Nov 30, 2024

Hesperidin inhibits oral cancer cell growth.Jan 31, 2024

The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study Mar 25, 2020

The protective effects of hesperidin and curcumin on 5-fluorouracil-induced nephrotoxicity.Apr 21, 2021

A combination of diosmin and hesperidin (Daflon) improves lymphatic flow indicating its therapeutic role in conditions like perivascular edema. Sep 01, 1995

A combination of diosmin and hesperidin (Detralex) attenuates adjuvant-induced arthritis in rats treated with methotrexate. May 01, 2008

A combination of diosmin and hesperidin is effective in the prevention of intestinal reperfusion injury in an experimental model in rats. Nov 01, 2004

A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury.Dec 31, 2015

A mixture of curcumin, hesperidin and rutin ameliorates hepatic oxidative stress caused by STZ-induced hyperglycemia.Aug 11, 2015

Ameliorative effect of hesperidin against motion sickness.Nov 27, 2019

Ameliorative effects of hesperidin and N-acetylcysteine against formaldehyde-induced-hemato- and genotoxicity.Sep 30, 2021

Ameliorative potentials of diosmin and hesperidin fractions on chlorpyriphos-induced changes in reproductive hormones, sperm characteristics, and testicular glycogen.Jun 20, 2024

Antifibrotic activity of hesperidin against dimethylnitrosamine-induced liver fibrosis in rats.May 31, 2014

Antinociceptive synergy between metamizole and hesperidin. Jan 18, 2021

Antiosteoporotic effect of hesperidin against ovariectomy-induced osteoporosis.May 23, 2021

Antioxidant responses driven by hesperetin and hesperidin counteract Parkinson's disease-like phenotypes.Feb 29, 2024

Based on activation of p62-Keap1-Nrf2 pathway, hesperidin protects arsenic-trioxide-induced cardiotoxicity.Dec 31, 2020

Bee venom plus hesperidin particularly seemed to be the most potent in improving rheumatoid arthritis in Wistar rats.May 31, 2018

Beta-Cryptoxanthin and Hesperidin are potential cancer chemopreventive agents against tongue, colon, and lung cancers. Jan 01, 2012

Both hesperidin and thymol were effective in suppressing allergic symptoms and inflammation in the treatment of allergic rhinitis.Nov 27, 2018

Citrus flavanones prevent systemic inflammation and ameliorate oxidative stress.Jun 14, 2016

Combination of metformin and hesperidin mitigates cyclophosphamide-induced hepatotoxicity.Mar 31, 2023

Combined treatment with naringenin and hesperetin might be a promising anti-cancer strategy for pancreatic cancers.Nov 19, 2018

Consumption of foods enriched with flavonoid fractions of diosmin and hesperidin may be beneficial for individuals inhabiting lead-polluted environments.Sep 30, 2021

Curcumin, beta-carontein and hesperidin prevent chemically-induced oral cancer.Sep 01, 1994

Dietary hesperidin suppresses lipopolysaccharide-induced inflammation in male mice.Dec 31, 2021

Diosmin and hesperidin may have protective effects against radiation-induced acute proctitis.Mar 31, 2011

Effect of hesperidin in the prevention of aluminum chloride-induced testicular dysfunction.Dec 31, 2023

Effect of hesperidin on chronic unpredictable mild stress-related depression.Aug 12, 2024

Effect of hesperidin on fluoride-induced neurobehavioral and biochemical changes in rats.Oct 31, 2020

Effect of hesperidin treatment on α-Klotho/FGF-23 pathway in rats with experimentally-induced diabetes.Dec 31, 2018

Effects in vitro and in vivo of hesperidin administration in an experimental model of acute lung inflammation.Jan 19, 2022

Hesperidin

View the Evidence:
358 Abstracts with Hesperidin Research