Hibiscus sabdariffa

Name	AC	CK
Hypertension	19	133
Obesity	11	51
Oxidative Stress	7	36
Inflammation	5	24
Urinary Tract Infections	5	24
Cardiovascular Diseases	5	23
Metabolic Syndrome X	4	23
Endothelial Dysfunction	2	20
Hypertension: Arterial	1	20
Dyslipidemias	3	13
Metabolic Diseases	2	12
Nonalcoholic fatty liver disease (NAFLD)	2	12
Anemia: Iron Deficiency	1	10
Chronic Kidney Disease (CKD)	1	10
Overweight	1	10
Triglycerides: Elevated	1	10
Diabetes Mellitus: Type 1	3	6
Diabetes Mellitus: Type 2	4	6
Kidney Stones	3	5
Chemically-Induced Liver Damage	2	4
Diabetes: Cognitive Dysfunction	2	4
Diabetic Nephropathy	2	4
Escherichia coli Infections	4	4
Hyperlipidemia	3	4
Insulin Resistance	2	4
Ovarian Diseases	2	4
Aging Skin	3	3
Alzheimer's Disease	2	3
DNA damage	2	3
Leukemia	2	3
Nephropathy	1	3
Pseudomonas aeruginosa	2	3
Staphylococcus aureus infection	3	3
Alcohol Toxicity	1	2
Aluminum Toxicity	1	2
Alzheimer’s disease	1	2
Anxiety	1	2
Brain Inflammation	1	2
Breast Cancer	2	2
Cadmium Poisoning	1	2
Candida Albicans	2	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Cognitive Decline/Dysfunction	1	2
Diabetes: Cardiovascular Illness	1	2
Diabetic Complications	1	2
Eye Damage	1	2
Fructose-Induced Toxicity	1	2
Gram-Positive Bacterial Infections	2	2
Helicobacter Pylori Infection	2	2
Hepatic Steatosis	1	2
High Fat Diet	1	2
Hypercholesterolemia	1	2
Hyperglycemia	1	2
Iron Overload	1	2
Lipopolysaccharide-Induced Toxicity	1	2
Liver Disease: Oxidative Stress	1	2
Melanoma	2	2
Memory Disorders	1	2
Multiple Sclerosis	1	2
Myocardial Infarction	1	2
Neurodegenerative Diseases	2	2
Prehypertension	1	2
Promyelocytic leukemia	2	2
Prostate Cancer	1	2
Prostate Cancer: Metastatic	1	2
Retinal Diseases	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Thrombus	1	2
Ultraviolet Radiation Induced Damage	1	2
Vitamin B 12 Deficiency	1	2
Aging	1	1
Autoimmune Diseases	1	1
Bacillus subtilis infections	1	1
Brain: Oxidative Stress	1	1
Breast Cancer: Triple Negative	1	1
Chronic Disease	1	1
Dental Caries	1	1
Foodborne Pathogens: Prevention/Food Preservation	1	1
Gastric Cancer	1	1
Gastric Ulcer	1	1
Gastroenteritis	1	1
Gingivitis	1	1
Gram-Negative Bacterial Infections	1	1
Herpes Simplex Virus Type 2	1	1
Heterocyclic Aromatic Amine Induced Toxicity	1	1
Klebsiella Infections	1	1
Macular Degeneration	1	1
Multiple Myeloma	1	1
Oral Cancer	1	1
Periodontal Diseases	1	1
Photooxidative Stress	1	1
Squamous cell carcinoma	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Streptococcus Infections	1	1

Name	AC	CK
Antihypertensive Agents	17	140
Antioxidants	25	82
Hypolipidemic	14	63
Anti-Inflammatory Agents	15	41
Hypoglycemic Agents	7	36
Anti-Bacterial Agents	10	29
Renoprotective	6	28
Hepatoprotective	7	22
Neuroprotective Agents	12	21
Cardioprotective	6	17
Angiotensin-Converting Enzyme Inhibitors	1	10
Appetite Suppresant	1	10
Malondialdehyde Down-regulation	1	10
Vasodilator Agents	5	9
Interleukin-6 Downregulation	4	7
Tumor Necrosis Factor (TNF) Alpha Inhibitor	4	6
Apoptotic	4	5
Antimicrobial	4	4
Antiproliferative	4	4
Cytoprotective	2	4
Anti-metastatic	2	3
Anticholesteremic Agents	2	3
Interleukin-1 beta downregulation	2	3
Acetylcholinesterase Inhibitor	1	2
Anti-Anxiety Agents	1	2
Anti-Apoptotic	1	2
Anti-Fibrotic	1	2
Anti-Platelet	1	2
Anti-leukemia Effects	1	2
Anticarcinogenic Agents	1	2
Antimutagenic Agents	1	2
Antiviral Agents	2	2
Autophagy Up-regulation	2	2
Brain-derived neurotrophic factor modulator	1	2
Cardiovascular Agents	1	2
Catalase Up-Regulation	1	2
Chemoprotective Agents	1	2
Gastrointestinal Agents	1	2
Interleukin-10 downregulation	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	2
Monocyte chemotattractant protein-1 (MCP-1) Inhibitor	1	2
NF-kappaB Inhibitor	1	2
Pancreato Protective Agents	1	2
Vasoprotective	1	2
Alpha-amylase inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Angiogenesis Inhibitors	1	1
Antifungal Agents	1	1
Antiparasitic Agents	1	1
Cell cycle arrest	1	1
Enzyme Inhibitors: Pancreatic Lipase	1	1
Genoprotective	1	1
Immunomodulatory	1	1
Superoxide Dismutase Up-regulation	1	1

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Pubmed Data : J Sci Food Agric. 2012 Feb 13. Epub 2012 Feb 13. PMID: 22331521

Article Published Date : Feb 13, 2012

Study Type : Human Study

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Substances : Hibiscus sabdariffa

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants

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Drinking H. sabdariffa tea twice a day can be effective in managing blood pressure in stage 1 hypertension along with lifestyle and dietary modification.Jun 30, 2019

Pubmed Data : Urol Res. 2011 Nov 5. Epub 2011 Nov 5. PMID: 22057204

Article Published Date : Nov 05, 2011

Study Type : Animal Study

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Substances : Hibiscus sabdariffa

Diseases : Kidney Stones

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An anthocyanin-rich extract of Hibiscus sabdariffa calyces had hepatoprotective activity.Aug 25, 2016

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Pubmed Data : Pharm Biol. 2016 Aug 26:1-10. Epub 2016 Aug 26. PMID: 27564372

Article Published Date : Aug 25, 2016

Study Type : Animal Study

Additional Links

Substances : Anthocyanins, Hibiscus sabdariffa

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

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An aqueous extract of Hibiscus sabdariffa palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in high-fructose induced metabolic syndrome rats.May 11, 2015

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Pubmed Data : J Sci Food Agric. 2015 May 12. Epub 2015 May 12. PMID: 25965053

Pubmed Data : J Sci Food Agric. 2018 Jun 26. Epub 2018 Jun 26. PMID: 29943479

Article Published Date : Jun 25, 2018

Study Type : Animal Study

Additional Links

Substances : Hibiscus sabdariffa

Diseases : Hepatic Steatosis

Pharmacological Actions : Hepatoprotective

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Combination of Lemon verbena and Hibiscus flower extract prevents high-fat diet-induced obesity.Aug 31, 2018

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Pubmed Data : Nutrients. 2018 Sep 1 ;10(9). Epub 2018 Sep 1. PMID: 30200432

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : Hibiscus sabdariffa , Lemon Verbena

Diseases : Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Anti-Obesity Agents

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Effect of Hibiscus sabdariffa on reducing steatosis and steatohepatitis in vitamin B12 deficiency.May 27, 2023

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Pubmed Data : J Urol. 2010 Nov 13. Epub 2010 Nov 13. PMID: 21075390

Article Published Date : Nov 13, 2010

Study Type : Animal Study

Additional Links

Substances : Hibiscus sabdariffa , Phyllanthus amarus

Diseases : Kidney Stones

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Hibiscus sabdariffa aqueous extract can reduce blood pressure.Dec 31, 2018

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Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:9694212. Epub 2019 Jul 17. PMID: 31379972

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Hibiscus sabdariffa

Diseases : Hypertension

Pharmacological Actions : Antihypertensive Agents

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Hibiscus sabdariffa calyx protect against oxidative stress and aluminium chloride-induced neurotoxicity in the brain.Dec 31, 2022

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Pubmed Data : In Vitro Cell Dev Biol Anim. 2010 Nov 17. Epub 2010 Nov 17. PMID: 21082285

Article Published Date : Nov 17, 2010

Study Type : Animal Study

Additional Links

Substances : Hibiscus sabdariffa

Diseases : Chemically-Induced Liver Damage, Liver Disease: Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

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Hibiscus sabdariffa holds therapeutic potential to counter iron neurotoxicity.Jan 26, 2022

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Nephroprotective effect of Hibiscus sabdariffa leaf flavonoid extracts.Apr 29, 2024

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Pubmed Data : ACS Omega. 2024 Apr 30 ;9(17):19334-19344. Epub 2024 Apr 19. PMID: 38708257

Article Published Date : Apr 29, 2024

Study Type : Animal Study

Additional Links

Substances : Hibiscus sabdariffa

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective

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OEE and HSE exerted negative inotropic and vasorelaxant effects without any chronotropic property with higher cytoprotective effects and antioxidant activities.Dec 31, 2014

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Pubmed Data : Oxid Med Cell Longev. 2015;2015:318125. Epub 2015 Jun 9. PMID: 26180582

Pubmed Data : J Ethnopharmacol. 2016 Oct 20. Epub 2016 Oct 20. PMID: 27773797

Article Published Date : Oct 19, 2016

Study Type : Animal Study

Additional Links

Substances : Hibiscus sabdariffa

Diseases : Lipopolysaccharide-Induced Toxicity, Urinary Tract Infections

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

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This review is an attempt to assess the antimicrobial efficacy of 10 plant extracts on dental caries and plaque microorganisms.Jun 30, 2015

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Pubmed Data : Int J Sci Eng Res. 2017 Feb ;8(2):299-307. PMID: 28459020

Article Published Date : Jan 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Anthocyanins, Hibiscus sabdariffa

Diseases : Macular Degeneration

Pharmacological Actions : Angiogenesis Inhibitors

Additional Keywords : Plant Extracts

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Anthocyanins from roselle extract arrest cell cycle G2/M phase transition via ATM/Chk pathway in p53-deficient leukemia HL-60 cells.Mar 31, 2017

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Pubmed Data : Environ Toxicol. 2017 Apr ;32(4):1290-1304. Epub 2016 Jul 22. PMID: 27444805

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Pubmed Data : Nutrients. 2022 Sep 16 ;14(18). Epub 2022 Sep 16. PMID: 36145217

Article Published Date : Sep 15, 2022

Study Type : In Vitro Study

Additional Links

Substances : Hibiscus sabdariffa

Diseases : Aging Skin

Pharmacological Actions : Antioxidants

Additional Keywords : Plant Extracts

Problem Substances : Phenanthrene, Polycyclic aromatic hydrocarbon

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Hibiscus sabdariffa has protective effects against Serum/glucose deprivation induced cytotoxicity in PC12 cells.Dec 31, 1969

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Study Type : In Vitro Study

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Substances : Hibiscus sabdariffa

Diseases : Neurodegenerative Diseases, Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

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Hibiscus sabdariffa in diabetes prevention and treatment-does it work.Jul 18, 2022

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Pubmed Data : Foods. 2022 Jul 19 ;11(14). Epub 2022 Jul 19. PMID: 35885378

Article Published Date : Jul 18, 2022

Study Type : Review

Additional Links

Substances : Hibiscus sabdariffa

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Hypolipidemic

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Hibiscus sabdariffa inhibits heterocyclic aromatic amine formation in fried meat.Aug 01, 2010

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Pubmed Data : Phytother Res. 2021 Mar 16. Epub 2021 Mar 16. PMID: 33724587

Article Published Date : Mar 15, 2021

Study Type : Review

Additional Links

Substances : Ginger, Hibiscus sabdariffa

Diseases : Cardiovascular Diseases

Pharmacological Actions : Cardioprotective

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Potential of Hibiscus sabdariffa and hibiscus acid to reverse skin aging. Sep 16, 2022

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Pubmed Data : J Sci Food Agric. 2020 Jan 30 ;100(2):672-681. Epub 2019 Nov 15. PMID: 31583701

Article Published Date : Jan 29, 2020

Study Type : In Vitro Study

Additional Links

Substances : Hibiscus sabdariffa

Diseases : Aging Skin, Photooxidative Stress

Therapeutic Actions : Sunlight exposure

Pharmacological Actions : Antioxidants

Additional Keywords : Plant Extracts

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Roselle is a potential genoprotectant agent against oxidative damage to cultured hematopoietic stem cells.Dec 31, 2013

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Pubmed Data : ScientificWorldJournal. 2014 ;2014:258192. Epub 2014 Oct 21. PMID: 25405216

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View the Evidence: 117 Abstracts with Hibiscus sabdariffa Research

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Efficacy of Hibiscus sabdariffa on reducing blood pressure in patients with mild to moderate hypertension.Oct 19, 2021

This meta-analysis of RCTs showed a significant effect of H. sabdariffa in lowering both SBP and DBP. May 31, 2015

Bioavailability of bioactive compounds in Hibiscus sabdariffa beverage as a potential anti-inflammatory.Nov 30, 2023

Consumption of hibiscus sabdariffa extracts reduced obesity, abdominal fat, serum FFA and improved liver steatosis.Mar 31, 2014

Consumption of Hibiscus sabdariffa L. water extract improves systemic antioxidant potential in healthy subjects.Feb 13, 2012

Drinking H. sabdariffa tea twice a day can be effective in managing blood pressure in stage 1 hypertension along with lifestyle and dietary modification.Jun 30, 2019

Effectiveness of D-mannose, Hibiscus sabdariffa and Lactobacillus plantarum therapy in prevention of infectious events following urodynamic study.Jul 31, 2019

Green tea and sour tea supplementation has beneficial effects on oxidative stress status in male athletes.May 03, 2017

H. sabdariffa extract improved metabolism, displayed potent anti-inflammatory and antioxidant activities, and significantly reduced blood pressure.May 31, 2014

H. sabdariffa is generally well tolerated and seems to be helpful in treating uncontrolled hypertension, with or without medication.Oct 09, 2019

H. sabdariffa significantly reduced serum triglycerides and systolic blood pressure.May 31, 2016

Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects.Jun 19, 2018

Hibiscus sabdariffa and Lippia citriodora) for could be used in reducing blood pressure in prehypertensive and type 1 hypertensive subjects. Mar 21, 2021

Hibiscus sabdariffa and Olea europaea had comparable antihypertensive efficacy and safety to captopril in Egyptian patients with grade 1 hypertension.Jul 28, 2020

Hibiscus sabdariffa consumption improved indices of renal function in patients with mild to moderate hypertension.May 23, 2016

Hibiscus sabdariffa could be a treatment for uncontrolled hypertension.May 18, 2021

Hibiscus sabdariffa exerts beneficial effects on inflammation, endothelial dysfunction, and oxidation, systemically inhibits the renin-angiotensin system and angiotensin-converting enzyme.Sep 01, 2015

Hibiscus sabdariffa extract as an adjunct to valsartan in patients with mild chronic kidney disease.Dec 31, 2023

Hibiscus sabdariffa may be a useful dietary strategy to reduce endothelial dysfunction and cardiovascular disease risk.Feb 04, 2019

Hibiscus sabdariffa meal improves iron status of childbearing age women and prevents stunting in their toddlers.Jan 18, 2019

It is concluded that Hibiscus sabdariffa lowered BP, HR and DP by modulating autonomic mechanisms.Jun 29, 2022

L-Methionine associated with Hibiscus sabdariffa and Boswellia serrata extracts for symptoms relief in patients affected by recurrent uncomplicated urinary tract infections.Jun 29, 2018

Lippia citriodora and Hibiscus sabdariffa is useful for the treatment of obesity and/or weight control in subjects without a controlled diet.Jan 05, 2020

Rosella has shown evidence to control and lower blood pressure, blood glucose, lipid profile, and cortisol in the elderly with metabolic syndrome.Dec 31, 2019

Sour tea may have significant positive effects on lipid profile of polygenic dyslipidemia subjectsDec 31, 2017

The supplementation with the Lc-Hs extract decreases appetite sensation in overweight and obese population.Sep 29, 2021

The nephroprotective effects of Hibiscus sabdariffa leaf and ellagic acid.Dec 22, 2022

Effects of Hibiscus sabdariffa calyces on spatial memory and hippocampal expression of BDNF in ovariectomized rats.Aug 12, 2020

A water extract of Hibiscus sabdariffa significantly lowers the deposition of stone-forming constituents in the kidneys and serum of urolithiatic rats.Nov 05, 2011

An anthocyanin-rich extract of Hibiscus sabdariffa calyces had hepatoprotective activity.Aug 25, 2016

An aqueous extract of Hibiscus sabdariffa palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in high-fructose induced metabolic syndrome rats.May 11, 2015

An extract of Hibiscus sabdariffa improves short-term memory in rats with experimental diabetic hyperglycemia.Jan 08, 2024

Anthocyanin content in Hibiscus sabdariffa and their antiplatelet and vasorelaxant properties.Apr 28, 2023

Anti-fibrotic actions of roselle extract in rat model of myocardial infarction.Aug 19, 2018

Anti-hypertensive effects of anthocyanins from Hibiscus sabdarifa.Jun 29, 2022

Anti-virulence activity of a dietary phytochemical: Hibiscus acid isolated from Hibiscus sabdariffa L. reduces the virulence of Pseudomonas aeruginosa.Mar 21, 2021

Antiapoptotic and antioxidant capacity of phytochemicals from Hibiscus sabdariffa and their potential effects on monosodium glutamate-induced testicular damage.Sep 03, 2020

Aqueous fraction from Hibiscus sabdariffa relaxes mesenteric arteries of normotensive and hypertensive rats.Jun 14, 2020

Calyxes from Hibiscus sabdariffa contain compounds that are different from anthocyanins, with potential benefits to health.Jun 25, 2018

Combination of Lemon verbena and Hibiscus flower extract prevents high-fat diet-induced obesity.Aug 31, 2018

Effect of Hibiscus sabdariffa on reducing steatosis and steatohepatitis in vitamin B12 deficiency.May 27, 2023

H. sabdariffa is a potent anti-inflammatory substance that prevents impairments in spatial memory consolidation.Oct 14, 2018

H. sabdariffa L. presented a protective effect to cyclophosphamide induced damage to DNA.Dec 31, 2016

H. sabdariffa may prevent the ethanol-induced deficits of motor coordination and estimated total number of Purkinje cells of the cerebellums in adolescent ratsDec 31, 2014

Hibiscus attenuates renovascular hypertension-induced aortic remodeling dose dependently.Dec 31, 2022

Hibiscus represents a promising safe agent that can be repurposed for Alzheimer's disease.Jul 31, 2020

Hibiscus sabdariffa and Olive leaf extracts could be useful in the treatment of preclinical hypertension.Apr 30, 2016

Hibiscus sabdariffa and Phyllanthus amaraus inhibit calcium oxalate stone formation in the rats.Nov 13, 2010

Hibiscus sabdariffa aqueous extract can reduce blood pressure.Dec 31, 2018

Hibiscus sabdariffa calyx protect against oxidative stress and aluminium chloride-induced neurotoxicity in the brain.Dec 31, 2022

Hibiscus sabdariffa exerts effects similar to those of linagliptin, which improves insulin resistance and epithelial to mesenchymal transition.Oct 07, 2014

Hibiscus sabdariffa extract ameliorated the biochemical and histological changes in the liver of Wistar rats following experimental induction of diabetes mellitus.Dec 31, 2013

Hibiscus sabdariffa extract led to the reduced invasiveness of prostate cancer cells.Dec 31, 2014

Hibiscus sabdariffa extract protects against cadmium-induced ovarian toxicity.Dec 31, 2019

Hibiscus sabdariffa has a lipid lowering effect in hyperlipidemic rats.Mar 01, 2010

Hibiscus sabdariffa has a remarkable potential to counteract UVC-caused impairments, probably through its antioxidant and free radical defusing effects.Mar 17, 2015

Hibiscus sabdariffa has cholesterol lowering and antioxidant effects in an experimental model of type 1 diabetes.Jun 01, 2009

Hibiscus sabdariffa has hepatoprotective and antioxidant effects against chemically-induced liver damage.Nov 17, 2010

Hibiscus sabdariffa holds therapeutic potential to counter iron neurotoxicity.Jan 26, 2022

Hibiscus sabdariffa L. attenuates diabetes-associated cognitive impairment in mice.Feb 28, 2018

Hibiscus sabdariffa L. calyx extract prevents the adipogenesis of 3T3-L1 adipocytes, and obesity-related insulin resistance.May 31, 2021

Hibiscus sabdariffa L. extracts increases lifespan and protects against amyloid-β toxicity in the model organism C. elegans.Jan 31, 2019

Hibiscus sabdariffa renews pancreatic β-cells in experimental type 1 diabetic model.May 31, 2019

Modulation of renal function in a metabolic syndrome rat model by antioxidants in Hibiscus sabdariffa.Apr 03, 2021

Nephroprotective effect of Hibiscus sabdariffa leaf flavonoid extracts.Apr 29, 2024

OEE and HSE exerted negative inotropic and vasorelaxant effects without any chronotropic property with higher cytoprotective effects and antioxidant activities.Dec 31, 2014

Oral administration of Hibiscus sabdariffa anthocyanins remarkably inhibited progression of NMU-induced leukemia by approximately 33% in rats.Feb 18, 2014

Rosella extract increase the catalase activity and expression of catalase antioxidant gene.Apr 30, 2018

Roselle seed oil reduces hyperlipidemia and hypercholesterolemia.Dec 31, 2016

The hibiscus anthocyanin delphinidin 3-sambubioside possessed potential anti-inflammatory properties.Dec 31, 2014

The prebiotic properties of Hibiscus sabdariffa extract contribute to the beneficial effects in diet-induced obesity.Dec 31, 2019

The results propose that the ethanol extract of Hibiscus rosa sinensis has prospective anxiolytic effect.Jan 24, 2018

Hibiscus sabdariffa

View the Evidence:
117 Abstracts with Hibiscus sabdariffa Research