Honeysuckle

Name	AC	CK
Coronavirus Infection	9	30
Inflammation	22	30
Oxidative Stress	20	23
Lipopolysaccharide-Induced Toxicity	10	16
Athletic Performance	1	10
Chemically-Induced Liver Damage	5	10
Nonalcoholic fatty liver disease (NAFLD)	5	9
Chemotherapy-Induced Toxicity: Cyclophosphamide	4	8
Aging	3	6
Diabetes Mellitus: Type 2	3	6
Obesity	3	6
Alzheimer's Disease	4	5
Atopic Dermatitis	2	5
Hydrogen Peroxide Induced Toxicity	4	5
Ulcerative Colitis	3	5
Alcoholic Liver Disease	2	4
Cerebral Ischemia	2	4
Colitis	2	4
Depression	2	4
High Fat Diet	2	4
Hyperuricemia	2	4
Influenza	4	4
Lung Injury: Acute	2	4
Alcohol Toxicity	2	3
Bacterial Infections	3	3
Coronavirus Disease	2	3
DNA damage	2	3
Endothelial Dysfunction	2	3
Escherichia coli Infections	3	3
Liver Cancer	3	3
Neurodegenerative Diseases	3	3
Rheumatoid Arthritis	2	3
Sepsis	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Animal Diseases: Porcine Epidemic Diarrhea Virus (PEDV)	1	2
Arthritis	1	2
Cancers: All	2	2
Candida Albicans	1	2
Chronic Obstructive Pulmonary Disease	1	2
Citrobacter Infection	1	2
Dermatitis: Contact	1	2
Diabetic Nephropathy	1	2
Dysbiosis	1	2
Dyslipidemias	1	2
Endotoxemia	1	2
Enterovirus 71	1	2
Gastric Ulcer	1	2
Hyperglycemia	1	2
Inflammatory Bowel Diseases	1	2
Liver Cirrhosis	1	2
Liver Fibrosis	1	2
Lung Cancer	2	2
Memory Disorders	1	2
Metabolic Diseases	1	2
Prediabetes	1	2
Radiotherapy	1	2
Ultraviolet Radiation Induced Damage	1	2
Air Pollution Linked Toxicity	1	1
Allergic Rhinitis	1	1
Bacillus Cereus infection	1	1
Brain: Oxidative Stress	1	1
Cadmium Poisoning	1	1
Cardiovascular Diseases	1	1
Cervical Cancer	1	1
Colon Cancer	1	1
Coxsackievirus Infections	1	1
Dermatophyte Infections	1	1
Fever	1	1
Gingivitis	1	1
HIV Infections	1	1
Hepatitis B	1	1
Hepatitis C	1	1
Histamine: Elevated	1	1
Human Papillomavirus (HPV)	1	1
Iron Overload	1	1
Leukemia	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Lung Damage	1	1
Osteomyelitis	1	1
Parkinson's Disease	1	1
Porphyromonas gingivalis	1	1
Pseudomonas aeruginosa	1	1
Rabies	1	1
Respiratory Infections	1	1
Rhinovirus Infection	1	1
Severe Acute Respiratory Syndrome	1	1
Wound Healing	1	1

Name	AC	CK
Anti-Inflammatory Agents	44	66
Antioxidants	36	46
Antiviral Agents	14	35
Hepatoprotective	14	24
Tumor Necrosis Factor (TNF) Alpha Inhibitor	14	24
Interleukin-6 Downregulation	12	19
Interleukin-1 beta downregulation	10	16
Gastrointestinal Agents	8	15
Neuroprotective Agents	11	14
Immunomodulatory	8	12
Anti-Apoptotic	8	11
Anti-Bacterial Agents	10	11
Hypoglycemic Agents	5	10
NF-kappaB Inhibitor	6	8
Antiproliferative	6	7
Apoptotic	6	6
Cyclooxygenase 2 Inhibitors	5	6
Hypolipidemic	3	6
Anti-Fibrotic	3	5
Cardioprotective	4	5
Interferon Gamma Reducer	3	5
Malondialdehyde Down-regulation	3	5
Superoxide Dismutase Up-regulation	3	5
Antidepressive Agents	2	4
Interleukin-17 downregulation	2	4
STAT3 Inhibitor	2	4
Uricosuric Agents	2	4
Antifungal Agents	2	3
Immunomodulatory: Th17 downregulation	2	3
Nrf2 activation	2	3
Anti-Allergic Agents	1	2
Anti-Ulcer Agents	1	2
Antidiarrheals	1	2
Antimicrobial	2	2
Autophagy Inhibitors	1	2
Brain-derived neurotrophic factor modulator	1	2
Cell cycle arrest	2	2
Chemoprotective Agents	1	2
Cytoprotective	2	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Gastroprotective	1	2
Heme oxygenase-1 up-regulation	2	2
Immunostimulatory	1	2
Interleukin-12 downregulation	1	2
Interleukin-2 Downregulation	1	2
Nitric Oxide Inhibitor	1	2
Photoprotective	1	2
Postaglandin PGE2 downregulation	1	2
Radioprotective	1	2
Renoprotective	1	2
Tyrosinase inhibitors	2	2
Xanthine oxidase inhibitor	1	2
Acetylcholinesterase Inhibitor	1	1
Anti-pyretic	1	1
Antineoplastic Agents	1	1
Antioxidant Effects	1	1
Bcl-2 protein down-regulation	1	1
Chemopreventive	1	1
Cholinesterase Inhibitors	1	1
HIV Protease Inhibitors	1	1
Histamine down-regulation	1	1
Interleukin-8 downregulation	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
Neuritogenic	1	1
Transforming growth factor beta (TGF-β) inhibitor	1	1
Wnt/β-catenin signaling pathway modulation	1	1

[+]

Honeysuckle combined with conventional therapy may be beneficial for the treatment of COVID-19 in improving lung CT, clinical cure rate, clinical symptoms.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Ethnopharmacol. 2020 Sep 9 ;264:113364. Epub 2020 Sep 9. PMID: 32916233

Article Published Date : Sep 08, 2020

Study Type : Animal Study

Additional Links

Substances : Honeysuckle

Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute

Pharmacological Actions : Anti-Inflammatory Agents

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Anti-hyperuricemic and anti-gouty arthritis activities of polysaccharide purified from Lonicera japonica.Feb 14, 2019

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2020 Aug ;45(16):3938-3944. PMID: 32893592

Flos Lonicera and metformin in combination exerts a synergistic effect on the improvement of hepatosteatosis and insulin sensitivity.Dec 31, 2016

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Pubmed Data : Front Microbiol. 2017 ;8:2271. Epub 2017 Nov 17. PMID: 29204141

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Honeysuckle

Diseases : Diabetes Mellitus: Type 2, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Gastrointestinal Agents, Hepatoprotective, Hypoglycemic Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Galuteolin exerts neuroprotective effects against CIRI by inhibiting apoptosis, oxidation, and inflammation.Dec 31, 2018

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Pubmed Data : Food Funct. 2013 Nov ;4(11):1654-61. PMID: 24081320

Article Published Date : Oct 31, 2013

Study Type : Animal Study

Additional Links

Substances : Anthocyanins, Honeysuckle

Diseases : Obesity

Additional Keywords : Anti-Obesity Agents, Plant Extracts

[+]

Honeysuckle aqueous extracts induced let-7a suppress EV71 replication and pathogenesis.Feb 15, 2021

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Pubmed Data : Viruses. 2021 Feb 16 ;13(2). Epub 2021 Feb 16. PMID: 33669264

Article Published Date : Feb 15, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Honeysuckle

Diseases : Coronavirus Infection, Enterovirus 71

Pharmacological Actions : Antiviral Agents

[+]

Honeysuckle berry inhibits lipase activity and modulates the gut microbiota in high-fat diet-fed mice.Jul 23, 2022

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Pubmed Data : Molecules. 2022 Jul 24 ;27(15). Epub 2022 Jul 24. PMID: 35897908

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Pubmed Data : PLoS One. 2018 ;13(10):e0204152. Epub 2018 Oct 8. PMID: 30296293

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Honeysuckle

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Immunomodulatory, Interferon Gamma Reducer, Interleukin-2 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts, Polysaccharides

[+]

Immunomodulatory effect of polysaccharides isolated from Lonicera japonica Thunb. in cyclophosphamide-treated BALB/c mice.Oct 31, 2022

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Pubmed Data : Int J Biol Macromol. 2023 Aug 1 ;245:125517. Epub 2023 Jun 22. PMID: 37353132

Article Published Date : Jul 31, 2023

Study Type : Animal Study

Additional Links

Substances : Honeysuckle

Diseases : Dysbiosis, Oxidative Stress

Pharmacological Actions : Antioxidants, Gastrointestinal Agents, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

Additional Keywords : Polysaccharides

[+]

Lonicera japonica flower bud may be useful for treating Citrobacter rodentium-induced digestive tract infection.Aug 26, 2020

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Pubmed Data : Br J Nutr. 2013 Jan 28 ;109(2):283-92. Epub 2012 May 9. PMID: 22569277

Article Published Date : Jan 27, 2013

Study Type : Animal Study

Additional Links

Substances : Honeysuckle

Diseases : Colitis, Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory: Th17 downregulation, Interferon Gamma Reducer, Interleukin-12 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Protective effect of a novel polysaccharide from Lonicera japonica on cardiomyocytes of mice injured by hydrogen peroxide.Dec 31, 2019

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Pubmed Data : Biomed Res Int. 2020 ;2020:5279193. Epub 2020 Jun 23. PMID: 32685499

[+]

This data uncovers the role of Lonicera japonica polysaccharides in extending lifespan and healthspan through DAF-16.Feb 27, 2023

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Pubmed Data : J Ethnopharmacol. 2021 Mar 1 ;267:113502. Epub 2020 Nov 12. PMID: 33189843

Article Published Date : Feb 28, 2021

Study Type : In Vitro Study

Additional Links

Substances : Honeysuckle

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells.Oct 14, 2013

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Pubmed Data : RSC Adv. 2023 May 22 ;13(23):15379-15390. Epub 2023 May 22. PMID: 37223411

Article Published Date : May 21, 2023

Study Type : In Vitro Study

Additional Links

Substances : Honeysuckle

Diseases : Bacillus Cereus infection

Pharmacological Actions : Anti-Bacterial Agents

[+]

Lonicera japonica extract inhibits lipopolysaccharide-stimulated inflammatory responses.Jun 30, 2015

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Pubmed Data : J Med Food. 2015 Jul ;18(7):762-75. Epub 2015 Apr 21. PMID: 25897683

Article Published Date : Jun 30, 2015

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation

[+]

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Pubmed Data : Food Chem Toxicol. 2020 May 12:111404. Epub 2020 May 12. PMID: 32413456

Article Published Date : May 11, 2020

Study Type : In Vitro Study

Additional Links

Substances : Anthocyanins, Honeysuckle

Diseases : DNA damage

Pharmacological Actions : Antioxidants, Cytoprotective

[+]

The results suggested that L. japonica polyphenols could be explored as a natural antioxidant and tyrosinase inhibitor.Apr 30, 2019

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Pubmed Data : Food Sci Nutr. 2019 May ;7(5):1786-1794. Epub 2019 Apr 21. PMID: 31139392

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Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2020 Mar ;45(6):1225-1231. PMID: 32281329

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View the Evidence: 130 Abstracts with Honeysuckle Research

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Honeysuckle combined with conventional therapy may be beneficial for the treatment of COVID-19 in improving lung CT, clinical cure rate, clinical symptoms.Dec 31, 2020

Improved endurance running performance following Lonicera caerulea ingestion.Feb 12, 2022

A homogeneous Lonicera japonica polysaccharide attenuates atopic dermatitis.Nov 25, 2023

A homogeneous Lonicera japonica polysaccharide alleviates atopic dermatitis.Jun 11, 2023

A water extract of Lonicera japonica has a gastroprotective effect via antioxidant and anti-inflammatory activities.Jan 31, 2019

An herbal formula inhibits STAT3 signalling and attenuates bone erosion in collagen-induced arthritis.May 29, 2020

An integrated network pharmacology and RNA-Seq approach for exploring the preventive effect of Lonicerae japonicae flos on LPS-induced acute lung injury.Sep 08, 2020

Anti-hyperuricemic and anti-gouty arthritis activities of polysaccharide purified from Lonicera japonica.Feb 14, 2019

Antiarthritic effect of lonicerin on Candida albicans arthritis in mice.Apr 30, 2011

Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid.Oct 31, 2023

Antihyperglycemic and antiobesity effects of JAL2 on db/db mice.Dec 31, 2015

Characterization and anti-allergic effect of a polysaccharide from the flower buds of Lonicera japonica.Nov 05, 2012

Chrysoeriol ameliorates TPA-induced acute skin inflammation.Feb 29, 2020

Comparative study on anti-inflammatory effect of Lonicerae Japonicae Flos and Lonicerae Flos.Jul 31, 2020

Constituents of L. fulvotomentosa and L. macranthoide are effective in decreasing carbon tetrachloride and D-Galactosamine-induced liver injuries.May 31, 1999

Effects of inhalable microparticle of flower of Lonicera japonica in a mouse model of COPD.Dec 31, 2013

Effects of Lonicera japonica on type 2 diabetes via PPAR-γ activation in rats.Sep 30, 2015

Effects of oral administration of Lonicera caerulea berries on UVB-induced damage in SKH-1 mice.Sep 30, 2013

Epimedium koreanum nakai water extract exhibits antiviral activity against porcine epidermic diarrhea virus.Dec 31, 2011

Flos Lonicera ameliorates obesity and associated endotoxemia.Dec 31, 2013

Flos Lonicera and metformin in combination exerts a synergistic effect on the improvement of hepatosteatosis and insulin sensitivity.Dec 31, 2016

Galuteolin exerts neuroprotective effects against CIRI by inhibiting apoptosis, oxidation, and inflammation.Dec 31, 2018

Galuteolin Inhibited Autophagy for neuroprotection against transient focal cerebral Ischemia.Jan 11, 2020

Hepatorotective activity of honeysuckle fruit extract in carbon tetrachloride intoxicated rats.Dec 31, 2013

Honeysuckle anthocyanin supplementation prevents diet-induced obesity in C57BL/6 mice.Oct 31, 2013

Honeysuckle aqueous extracts induced let-7a suppress EV71 replication and pathogenesis.Feb 15, 2021

Honeysuckle berry inhibits lipase activity and modulates the gut microbiota in high-fat diet-fed mice.Jul 23, 2022

Honeysuckle extract (Lonicera pallasii L.) exerts antioxidant properties and extends the lifespan and healthspan of Drosophila melanogaster.Feb 04, 2022

HS-23, Lonicera japonica extract, attenuates septic injury by suppressing toll-like receptor 4 signaling.Aug 07, 2014

Hydroxytyrosol alleviates dextran sulfate sodium-induced colitis.Feb 07, 2022

Hypoglycemic and hypolipidemic effects of a polysaccharide from flower buds of Lonicera japonica in streptozotocin-induced diabetic rats.Aug 31, 2017

Immunomodulatory activity of a novel polysaccharide from Lonicera japonica in immunosuppressed mice induced by cyclophosphamide.Dec 31, 2017

Immunomodulatory effect of polysaccharides isolated from Lonicera japonica Thunb. in cyclophosphamide-treated BALB/c mice.Oct 31, 2022

Lonicera caerulea juice alleviates alcoholic liver disease by regulating intestinal flora.Sep 16, 2023

Lonicera hypoglauca inhibits xanthine oxidase and reduces serum uric acid in mice.Feb 28, 2009

Lonicera japonica extends lifespan and healthspan in Caenorhabditis elegans.Jan 11, 2018

Lonicera japonica polysaccharide improved behavioral changes and neuronal loss associated with LPS-induced learning and memory impairments. Sep 14, 2020

Lonicera japonica polysaccharides alleviate D-galactose-induced oxidative stress and restore gut microbiota.Jul 31, 2023

Lonicera japonica flower bud may be useful for treating Citrobacter rodentium-induced digestive tract infection.Aug 26, 2020

Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease.Nov 30, 2023

Lonicerae japonicae flos ameliorates radiotherapy-induced mesenteric artery endothelial dysfunction.Jul 19, 2022

Lonicerae Japonicae Flos extract and chlorogenic acid attenuates high-fat-diet- induced prediabetes.Dec 31, 2021

Lonicerin prevents inflammation and apoptosis in LPS-induced acute lung injury.Dec 31, 2019

Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation.Aug 31, 2021

Metabonomics study of the protective effects of Lonicera japonica extract on acute liver injury. Sep 20, 2010

Optimization of protein removal process of Lonicera japonica polysaccharide and its immunomodulatory mechanism in a cyclophosphamide model.Dec 31, 2022

Prophylactic effects of Lonicera japonica extract on dextran sulphate sodium-induced colitis.Jan 27, 2013

Protective effect of a novel polysaccharide from Lonicera japonica on cardiomyocytes of mice injured by hydrogen peroxide.Dec 31, 2019

Protective effects of Flos lonicera extract on acute liver injury by dimethylnitrosamine.Jun 30, 2010

Protective effects of fulvotomentosides on acetaminophen-induced hepatotoxicity.Apr 30, 1992

Protective effects of fulvotomentosides on cadmium-induced hepatotoxicity.Apr 30, 1992

Protective effects of Lonicerae Japonicae Flos against acute alcoholic liver injury.Aug 31, 2021

Protective role of a new polysaccharide extracted from Lonicera japonica in mice with ulcerative colitis.Dec 31, 2020

Structural characterization and protective effect of Lonicerae flos polysaccharide on cyclophosphamide-induced immunosuppression in mice.Jan 05, 2022

The combination of Lonicerae Japonicae Flos and Forsythiae Fructus herb-pair alleviated inflammation in liver fibrosis.Dec 31, 2021

The ethanol extract of Lonicera japonica attenuates diabetic nephropathy.Jan 31, 2014

The protective effect of Lonicera japonica polysaccharide on mice with depression by inhibiting NLRP3 inflammasome.Nov 30, 2019

This data uncovers the role of Lonicera japonica polysaccharides in extending lifespan and healthspan through DAF-16.Feb 27, 2023

This reports of Caulis Lonicerae japonicae especially its anti-inflammatory effects and correlative components.May 31, 2016

This study demonstrated the protective role of L. japonica ethanol extract in ameliorating nutritional steatohepatitis.Oct 20, 2015

A glucan isolated from flowers of Lonicera japonica Thunb. inhibits aggregation and neurotoxicity of Aβ42.Sep 21, 2014

A novel polysaccharide from Lonicerae Japonicae Caulis: Characterization and effects on the function of fibroblast-like synoviocytes.Sep 14, 2022

Anti-inflammatory property and functional substances of Lonicerae Japonicae Caulis.Feb 28, 2021

Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells.Oct 14, 2013

Antifungal potential of essential oil and ethanol extracts of Lonicera japonica Thunb. against dermatophytes.Dec 31, 2013

Antioxidant effects of phenolic compounds in through the distillation of Lonicera japonica & Chenpi extract and anti-inflammation.Nov 27, 2023

Application of proteomics to identify the target molecules involved in Lonicera japonica-induced photokilling in human lung cancer CH27 cells.Sep 30, 2013

Berry derived constituents in suppressing viral infection: Potential avenues for viral pandemic management.Jan 11, 2021

Bioactivity-guided screening identifies pheophytin a as a potent anti-hepatitis C virus compound from Lonicera hypoglauca Miq.Jul 23, 2009

Characterization of a pectin from Lonicera japonica Thunb. and its inhibition effect on Aβ42 aggregation and promotion of neuritogenesis.Jan 31, 2018

Chemical constituents of Lonicera japonica roots and their anti-inflammatory effects.Dec 31, 2015

Comparison of anti-bacterial activity of three types of di-O-caffeoylquinic acids in Lonicera japonica flowers based on microcalorimetry.Jan 31, 2014

Honeysuckle

View the Evidence:
130 Abstracts with Honeysuckle Research