Horse Chestnut

Name	AC	CK
Aging	1	10
Aging Skin	1	10
Chronic Venous Insufficency	1	10
Thyroid Cancer	1	10
Venous Insufficiency	1	10
Lipopolysaccharide-Induced Toxicity	5	8
Inflammation	5	7
Oxidative Stress	4	7
Osteosarcoma	4	6
Neuropathic Pain	3	5
Pancreatic Cancer	3	5
Cerebral Ischemia	3	4
Hepatitis: Lectin-Induced (concanavalin)	2	4
Lipid Peroxidation	2	4
Liver Damage: Drug-Induced	2	4
Lung Cancer	3	4
Obesity	2	4
Osteoarthritis	2	4
Asthma	1	3
Bladder Cancer	1	3
Cancer Metastasis	3	3
Parkinson's Disease	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Atopic Dermatitis	1	2
Brain Inflammation	1	2
Cancers: All	2	2
Candida Glabrata	2	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chronic Pain	1	2
Diabetic Nephropathy	1	2
Diabetic Neuropathy	1	2
Drug-Induced Toxicity: Indomethacin	1	2
Endotoxemia	1	2
Gastric Ulcer	1	2
High Fat Diet	1	2
Hyperalgesia	1	2
Intracerebral Hemorrhage	1	2
Liver Cancer	2	2
Liver Damage	1	2
Lymphedema	1	2
Melanoma	2	2
Osteopenia	1	2
Respiratory Syncytial Virus Infections	1	2
Sciatic Nerve Crush Injury	1	2
Sperm Quality: Low	1	2
Stroke: Ischemic	1	2
Brain: Oxidative Stress	1	1
Breast Cancer	1	1
Breast Cancer: Triple Negative	1	1
Cancers: Drug Resistant	1	1
Cancers: Multi-Drug Resistant	1	1
Chemotherapy-Induced Toxicity: Cisplatin	1	1
Cholangiocarcinoma	1	1
Colon Cancer	1	1
Colorectal Cancer	1	1
Coronavirus Disease (Covid-19)	1	1
Coronavirus Infection	1	1
Dementia	1	1
Diabetes Mellitus: Type 2	1	1
Endothelial Dysfunction	1	1
Gastric Cancer	1	1
Glioblastoma	1	1
Glioma	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Hypoxia	1	1
Kidney Cancer	1	1
Memory Disorders	1	1
Periodontitis	1	1
Prostate Cancer	1	1
Smoking	1	1
Wound Healing	1	1

Name	AC	CK
Anti-Inflammatory Agents	19	31
Antiproliferative	19	25
Apoptotic	20	24
Tumor Necrosis Factor (TNF) Alpha Inhibitor	9	17
Antioxidants	9	16
NF-kappaB Inhibitor	9	14
Neuroprotective Agents	7	11
Anti-Apoptotic	6	10
Chemotherapeutic	1	10
Interleukin-1 beta downregulation	6	10
Chemoprotective Agents	3	6
Hepatoprotective	3	6
Analgesics	3	5
Anti-Allergic Agents	2	5
Antineoplastic Agents	3	5
Interleukin-6 Downregulation	3	5
Autophagy Inhibitors	2	4
Osteoprotective	2	4
Superoxide Dismutase Up-regulation	2	4
Antiviral Agents	2	3
Cell cycle arrest	3	3
Chemosensitizer	3	3
Anti-Ulcer Agents	1	2
Anti-metastatic	2	2
Antinoceceptive	1	2
Cyclooxygenase 2 Inhibitors	1	2
Fertility Agents: Male	1	2
Immunomodulatory	1	2
Interferon Gamma Reducer	1	2
Interleukin-17 downregulation	1	2
Neuritogenic	1	2
Renoprotective	1	2
Alpha-glucosidase inhibitor	1	1
Angiogenesis Inhibitors	1	1
Anti-Bacterial Agents	1	1
Antifungal Agents	1	1
Cardioprotective	1	1
Cyclin D1 Down-Regulation	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1

[+]

Horse chesnut is an effective and safe treatment for Chronic Venous InsufficiencyJan 01, 2004

Click here to read the entire abstract

Pubmed Data : Cochrane Database Syst Rev. 2004;(2):CD003230. PMID: 15106197

Article Published Date : Jan 01, 2004

Study Type : Human Study

Additional Links

Substances : Horse Chestnut

Diseases : Chronic Venous Insufficency, Venous Insufficiency

[+]

Horse chestnut extract exhibits potent anti-aging properties in human skin.Sep 01, 2006

Click here to read the entire abstract

Pubmed Data : J Cosmet Sci. 2006 Sep-Oct;57(5):369-76. PMID: 17111071

Article Published Date : Sep 01, 2006

Study Type : Human Study

Additional Links

Substances : Horse Chestnut

Diseases : Aging, Aging Skin

Additional Keywords : Plant Extracts

[+]

The positive clinical therapeutically effects of Escin on advanced thyroid cancer.Apr 30, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Med. 2017 May ;6(5):937-943. Epub 2017 Apr 4. PMID: 28378396

Article Published Date : Apr 30, 2017

Study Type : Human Study

Additional Links

Substances : Horse Chestnut

Diseases : Thyroid Cancer

Pharmacological Actions : Chemotherapeutic

[+]

Beta-escin has potent anti-allergic efficacy and reduces allergic airway inflammation.May 20, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Immunol. 2010 May 21 ;11:24. Epub 2010 May 21. PMID: 20487574

Article Published Date : May 20, 2010

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Asthma

Pharmacological Actions : Anti-Allergic Agents

[+]

Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-κB and nuclear factor-κB-regulated gene products in pancreatic cancer.Apr 30, 2012

Click here to read the entire abstract

Pubmed Data : J Cancer Res Clin Oncol. 2012 May ;138(5):785-97. Epub 2012 Jan 24. PMID: 22270965

Article Published Date : Apr 30, 2012

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Pancreatic Cancer

Pharmacological Actions : Anti-Apoptotic, Antiproliferative , NF-kappaB Inhibitor

Additional Keywords : Chemotherapeutic Synergy: Gemcitabine

[+]

Escin induces apoptosis in human bladder cancer cells.Dec 04, 2018

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2018 Dec 5 ;840:79-88. Epub 2018 Oct 1. PMID: 30287153

Article Published Date : Dec 04, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Bladder Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

[+]

Escin induces caspase-dependent apoptosis and autophagy through the ROS/p38 MAPK signalling pathway in human osteosarcoma cells.Oct 11, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Death Dis. 2017 Oct 12 ;8(10):e3113. Epub 2017 Oct 12. PMID: 29022891

Article Published Date : Oct 11, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Osteosarcoma

Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Inhibitors

[+]

Ameliorative effects of escin on neuropathic pain induced by chronic constriction injury of sciatic nerve.Feb 28, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Ethnopharmacol. 2021 Mar 1 ;267:113503. Epub 2020 Oct 19. PMID: 33091488

Article Published Date : Feb 28, 2021

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Neuropathic Pain, Sciatic Nerve Crush Injury

Pharmacological Actions : Analgesics, Neuritogenic, NF-kappaB Inhibitor

[+]

Anti-inflammatory effects of escin are correlated with the glucocorticoid receptor/NF-κB signaling pathway.Jul 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Ther Med. 2013 Aug ;6(2):419-422. Epub 2013 May 22. PMID: 24137201

Article Published Date : Jul 31, 2013

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Antiobese effects of novel saponins from edible seeds of Japanese horse chestnut.Jun 24, 2008

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2008 Jun 25 ;56(12):4783-8. Epub 2008 May 31. PMID: 18512932

Article Published Date : Jun 24, 2008

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Obesity

Additional Keywords : Anti-Obesity Agents

[+]

Effects of alpha-Escin on mechanical features of the femoral bone in rats with experimental post-steroid osteopenia.Dec 31, 1999

Click here to read the entire abstract

Pubmed Data : Acta Pol Pharm. 2000 ;57(4):317-20. PMID: 11126622

Article Published Date : Dec 31, 1999

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Osteopenia

Pharmacological Actions : Osteoprotective

[+]

Effects of escin mixture from the seeds of Aesculus hippocastanum on obesity in mice fed a high fat diet.Feb 28, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharm Biol. 2010 Mar ;48(3):247-52. PMID: 20645808

Article Published Date : Feb 28, 2010

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : High Fat Diet, Obesity

Additional Keywords : Anti-Obesity Agents, Phytotherapy, Plant Extracts

Problem Substances : Insulin

[+]

Effects of escin on acute inflammation and the immune system in mice.Dec 31, 2008

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacol Rep. 2009 ;61(4):697-704. PMID: 19815952

Article Published Date : Dec 31, 2008

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Escin alleviates chemotherapy-induced peripheral neuropathic pain.Nov 29, 2020

Click here to read the entire abstract

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2020 Nov 30 ;40(11):1634-1638. PMID: 33243746

Article Published Date : Nov 29, 2020

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Hyperalgesia, Neuropathic Pain

Pharmacological Actions : Chemoprotective Agents, Neuroprotective Agents

[+]

Escin alleviates peripheral neuropathy in streptozotocin induced diabetes in rats.Jul 31, 2020

Click here to read the entire abstract

Pubmed Data : Life Sci. 2020 Aug 1 ;254:117777. Epub 2020 May 11. PMID: 32407839

Article Published Date : Jul 31, 2020

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Diabetic Neuropathy

Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation

[+]

Escin alleviates stress-induced intestinal dysfunction to protect brain injury.Jan 31, 2023

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2023 Feb ;115:109659. Epub 2023 Jan 4. PMID: 36608442

Article Published Date : Jan 31, 2023

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Lipopolysaccharide-Induced Toxicity, Stroke: Ischemic

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor

Additional Keywords : Gut-brain Axis

[+]

Escin ameliorates the impairments of neurological function and blood brain barrier by inhibiting systemic inflammation in intracerebral hemorrhagic mice.Feb 28, 2021

Click here to read the entire abstract

Pubmed Data : Exp Neurol. 2021 Mar ;337:113554. Epub 2020 Dec 10. PMID: 33309746

Article Published Date : Feb 28, 2021

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Intracerebral Hemorrhage

Pharmacological Actions : Neuroprotective Agents

[+]

Escin attenuates acute lung injury induced by endotoxin in mice.Jan 17, 2011

Click here to read the entire abstract

Pubmed Data : Eur J Pharm Sci. 2011 Jan 18 ;42(1-2):73-80. Epub 2010 Oct 30. PMID: 21040784

Article Published Date : Jan 17, 2011

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Antioxidants, Interleukin-1 beta downregulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Escin attenuates behavioral impairments, oxidative stress and inflammation in model of Parkinson's disease.Oct 16, 2014

Click here to read the entire abstract

Pubmed Data : Brain Res. 2014 Oct 17 ;1585:23-36. Epub 2014 Mar 20. PMID: 24657313

Article Published Date : Oct 16, 2014

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Brain Inflammation , Oxidative Stress, Parkinson's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Escin attenuates cognitive deficits and hippocampal injury after transient global cerebral ischemia.Aug 31, 2010

Click here to read the entire abstract

Pubmed Data : Neurochem Int. 2010 Sep ;57(2):119-27. Epub 2010 May 11. PMID: 20466027

Article Published Date : Aug 31, 2010

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Cerebral Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

[+]

Escin attenuates oxidative damage, apoptosis and lipid peroxidation in a model of cyclophosphamide-induced liver damage.Apr 30, 2022

Click here to read the entire abstract

Pubmed Data : Drug Chem Toxicol. 2022 May ;45(3):1180-1187. Epub 2020 Aug 24. PMID: 32838567

Article Published Date : Apr 30, 2022

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Lipid Peroxidation, Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Chemoprotective Agents, Hepatoprotective

[+]

Escin improves sperm quality in male patients with varicocele-associated infertility.Feb 28, 2010

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2010 Mar ;17(3-4):192-6. Epub 2009 Aug 13. PMID: 19682880

Article Published Date : Feb 28, 2010

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Sperm Quality: Low

Pharmacological Actions : Fertility Agents: Male

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Escin increases the survival rate of LPS-induced septic mice.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : Cell Physiol Biochem. 2015 ;36(4):1577-86. PMID: 26159678

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Endotoxemia, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Escin inhibits type I allergic dermatitis in a novel porcine model.Dec 31, 2012

Click here to read the entire abstract

Pubmed Data : Int Arch Allergy Immunol. 2013 ;161(1):44-52. Epub 2012 Dec 14. PMID: 23257653

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Atopic Dermatitis

Pharmacological Actions : Anti-Allergic Agents

[+]

Escin protects against acetaminophen-induced liver injury.Dec 31, 2018

Click here to read the entire abstract

Pubmed Data : Am J Transl Res. 2019 ;11(8):5170-5182. Epub 2019 Aug 15. PMID: 31497232

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Escin shows extended antioxidant, anti-inflammatory, antinecrotic, and anti-apoptotic effects against Con A-induced immune-mediated hepatitis.Nov 30, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Inflammopharmacology. 2022 Dec ;30(6):2317-2329. Epub 2022 Sep 5. PMID: 36063304

Article Published Date : Nov 30, 2022

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Hepatitis: Lectin-Induced (concanavalin)

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Concanavalin A

[+]

Evaluation of the effect of polyphenol of escin compared with ibuprofen and dexamethasone in synoviocyte model for osteoarthritis.Aug 31, 2018

Click here to read the entire abstract

Pubmed Data : Clin Rheumatol. 2018 Sep ;37(9):2471-2478. Epub 2018 Apr 16. PMID: 29663159

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Dexamethasone, Ibuprofen

[+]

Horse chestnut extract could significantly protect the concanavalin A-induced acute liver injury.Jul 22, 2019

Click here to read the entire abstract

Pubmed Data : Pharmacology. 2019 Jul 23:1-11. Epub 2019 Jul 23. PMID: 31336368

Article Published Date : Jul 22, 2019

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Hepatitis: Lectin-Induced (concanavalin), Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interferon Gamma Reducer, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Concanavalin A

[+]

Horse chestnut seeds had beneficial effects on the functional properties of the kidney and microscopic improvements in diabetic nephropathy.Sep 30, 2016

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2016 Oct ;83:392-396. Epub 2016 Jul 15. PMID: 27424320

Article Published Date : Sep 30, 2016

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Diabetic Nephropathy, Oxidative Stress

Pharmacological Actions : Antioxidants, Renoprotective

[+]

Horse chestnut. seed extract shows virucidal and antiviral activities against respiratory syncytial virusMar 31, 2019

Click here to read the entire abstract

Pubmed Data : Antiviral Res. 2019 Apr ;164:1-11. Epub 2019 Jan 31. PMID: 30711418

Article Published Date : Mar 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Respiratory Syncytial Virus Infections

Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents, Immunomodulatory

[+]

Influence of alpha-escin on the femoral bone strength in ovariectomized rats.Dec 31, 1998

Click here to read the entire abstract

Pubmed Data : Pol J Pharmacol. 1999 ;51(6):511-5. PMID: 10817529

Article Published Date : Dec 31, 1998

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Osteoarthritis

Pharmacological Actions : Osteoprotective

Additional Keywords : Ovariectomy-Induced Changes

[+]

Protective effects of escin against indomethacin-induced gastric ulcer.Nov 30, 2014

Click here to read the entire abstract

Pubmed Data : Toxicol Mech Methods. 2014 Dec ;24(8):560-6. PMID: 25137224

Article Published Date : Nov 30, 2014

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Drug-Induced Toxicity: Indomethacin, Gastric Ulcer, Lipid Peroxidation

Pharmacological Actions : Anti-Inflammatory Agents, Anti-Ulcer Agents, Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Indomethacin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

The antinociceptive effect of intrathecal escin in the rat formalin test.Jan 14, 2012

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2012 Jan 15 ;674(2-3):234-8. Epub 2011 Oct 26. PMID: 22061687

Article Published Date : Jan 14, 2012

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Chronic Pain

Pharmacological Actions : Analgesics, Antinoceceptive

[+]

The role of escin as a topical agent for lymphedema treatment.Aug 21, 2023

Click here to read the entire abstract

Pubmed Data : Int J Low Extrem Wounds. 2023 Aug 22:15347346231195944. Epub 2023 Aug 22. PMID: 37605640

Article Published Date : Aug 21, 2023

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Lymphedema

[+]

β-Escin inhibits NNK-induced lung adenocarcinoma.Sep 30, 2013

Click here to read the entire abstract

Pubmed Data : Cancer Prev Res (Phila). 2013 Oct ;6(10):1140-9. Epub 2013 Aug 20. PMID: 23963803

Article Published Date : Sep 30, 2013

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Lung Cancer

Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Plant Extracts

[+]

A review of edible nuts for memory.Dec 31, 2019

Click here to read the entire abstract

Pubmed Data : Curr Pharm Des. 2020 ;26(37):4712-4720. PMID: 32767923

Article Published Date : Dec 31, 2019

Study Type : Review

Additional Links

Substances : Almond, Brazil nut, Cashew, Hazelnut , Horse Chestnut, Peanut, Pecan, Pistachio nut , Walnut

Diseases : Dementia, Memory Disorders

Pharmacological Actions : Neuroprotective Agents

[+]

Aescin protects neuron from ischemia-reperfusion injury.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:7815325. Epub 2020 Sep 30. PMID: 33062146

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Cerebral Ischemia, Hypoxia

Pharmacological Actions : Neuroprotective Agents

[+]

Armoracia Rusticana might potentially be used in the amelioration of type 2 diabetes.May 25, 2020

Click here to read the entire abstract

Pubmed Data : Comb Chem High Throughput Screen. 2020 May 26. Epub 2020 May 26. PMID: 32452324

Article Published Date : May 25, 2020

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Alpha-glucosidase inhibitor

[+]

Cytotoxic effects of escin on human castration-resistant prostate cancer cells.Sep 30, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Urology. 2014 Oct ;84(4):982.e1-7. Epub 2014 Aug 12. PMID: 25123426

Article Published Date : Sep 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Prostate Cancer

Pharmacological Actions : Apoptotic

[+]

Deciphering the molecular mechanism of escin against neuropathic pain.Dec 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2023 ;2023:3734861. Epub 2023 Oct 16. PMID: 37876856

Article Published Date : Dec 31, 2022

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Neuropathic Pain

Pharmacological Actions : Analgesics

[+]

Effect of escin alone or in combination with antifungal agents on resistant Candida glabrata biofilms.Jul 19, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antibiotics (Basel). 2023 Jul 20 ;12(7). Epub 2023 Jul 20. PMID: 37508306

Article Published Date : Jul 19, 2023

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Candida Glabrata

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation

[+]

Effects of escin on oxidative stress and apoptosis of H9c2 cells induced by H2O2.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Dis Markers. 2022 ;2022:7765353. Epub 2022 Jan 27. PMID: 35126791

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Hydrogen Peroxide Induced Toxicity, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective

[+]

Escin alleviates cerebral ischemia-induced intestinal pyroptosis via the GR-dependent p38 MAPK/NF-κB signaling and NLRP3 inflammasome activation.Sep 09, 2024

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2024 Sep 10 ;138:112592. Epub 2024 Jul 2. PMID: 38955024

Article Published Date : Sep 09, 2024

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Cerebral Ischemia, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor

[+]

Escin ameliorates inflammation via inhibiting mechanical stretch and chemically induced Piezo1 activation.Oct 04, 2023

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2023 Oct 5 ;956:175951. Epub 2023 Aug 2. PMID: 37541373

Article Published Date : Oct 04, 2023

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Escin could be used as a novel molecular therapy for pancreatic cancer.Apr 30, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Rep. 2021 May ;45(5). Epub 2021 Mar 24. PMID: 33760162

Article Published Date : Apr 30, 2021

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative

[+]

Escin enhanced the efficacy of sorafenib by autophagy-mediated apoptosis in lung cancer cells.Sep 30, 2023

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2023 Oct ;37(10):4819-4837. Epub 2023 Jul 19. PMID: 37468281

Article Published Date : Sep 30, 2023

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Inhibitors, Cell cycle arrest

[+]

Escin Ia suppresses the metastasis of triple-negative breast cancer.Apr 25, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2016 Apr 26 ;7(17):23684-99. PMID: 27008697

Article Published Date : Apr 25, 2016

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Breast Cancer: Triple Negative , Cancer Metastasis

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

[+]

Escin induces apoptosis in human renal cancer cells.Jan 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Rep. 2017 Feb ;37(2):1002-1010. Epub 2017 Jan 3. PMID: 28075477

Article Published Date : Jan 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Kidney Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

[+]

Escin induces cell death in human skin melanoma cells through apoptotic mechanisms.Jul 31, 2024

Click here to read the entire abstract

Pubmed Data : Toxicol Res (Camb). 2024 Aug ;13(4):tfae124. Epub 2024 Aug 5. PMID: 39108844

Article Published Date : Jul 31, 2024

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Melanoma

Pharmacological Actions : Apoptotic

[+]

Escin inhibits lipopolysaccharide-induced inflammation in human periodontal ligament cells.Oct 31, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2012 Nov ;6(5):1150-4. Epub 2012 Aug 10. PMID: 22895831

Article Published Date : Oct 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Periodontitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Escin mitigates chronic MPTP/p-induced dopaminergic toxicity.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : J Mol Neurosci. 2015 Jan ;55(1):184-197. Epub 2014 May 2. PMID: 24788336

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Brain: Oxidative Stress, Parkinson's Disease

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

[+]

Escin reduces cell proliferation and induces apoptosis on glioma and lung adenocarcinoma cell lines.Sep 30, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cytotechnology. 2015 Oct ;67(5):893-904. Epub 2015 Apr 24. PMID: 25906387

Article Published Date : Sep 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Glioma, Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Selective Cytotoxicity

[+]

Escin sensitized pancreatic cancer cells to chemotherapy.Dec 31, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biochem Res Int. 2013 ;2013:251752. Epub 2013 Oct 27. PMID: 24282639

Article Published Date : Dec 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Pancreatic Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Chemosensitizer, Cyclin D1 Down-Regulation, NF-kappaB Inhibitor

Additional Keywords : Drug: Gemcitabine

[+]

Escin suppresses HMGB1-induced overexpression of aquaporin-1 and increased permeability in endothelial cells.Apr 30, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : FEBS Open Bio. 2019 May ;9(5):891-900. Epub 2019 Apr 10. PMID: 30972964

Article Published Date : Apr 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Endothelial Dysfunction

[+]

Escin suppresses migration and invasion involving the alteration of CXCL16/CXCR6 axis in human gastric adenocarcinoma AGS cells.Dec 31, 2013

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2014 ;66(6):938-45. Epub 2014 Jun 9. PMID: 24911042

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Cancer Metastasis, Gastric Cancer

Pharmacological Actions : Antiproliferative

[+]

Escin's multifaceted therapeutic profile in treatment and post-treatment of vrious cancers.Feb 06, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomolecules. 2023 Feb 7 ;13(2). Epub 2023 Feb 7. PMID: 36830684

Article Published Date : Feb 06, 2023

Study Type : Review

Additional Links

Substances : Horse Chestnut

Diseases : Cancers: All

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Anti-metastatic, Apoptotic

Additional Keywords : Plant Extracts

[+]

Escin, a natural mixture of triterpene saponins, exhibits antitumor activity against hepatocellular carcinoma.Nov 30, 2009

Click here to read the entire abstract

Pubmed Data : Planta Med. 2009 Dec ;75(15):1580-5. PMID: 19579181

Article Published Date : Nov 30, 2009

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.Apr 30, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Pharmacol. 2010 May ;77(5):818-27. Epub 2010 Jan 26. PMID: 20103608

Article Published Date : Apr 30, 2010

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Cancer Metastasis

Pharmacological Actions : Apoptotic, Chemosensitizer, NF-kappaB Inhibitor

[+]

Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells.Sep 30, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Pharmacol Sin. 2018 Oct ;39(10):1645-1660. Epub 2018 May 31. PMID: 29849127

Article Published Date : Sep 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Colorectal Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

[+]

Escin-sorafenib synergy up-regulates LC3-II and p62 to induce apoptosis in hepatocellular carcinoma cells.Jan 31, 2024

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Environ Toxicol. 2024 Feb ;39(2):840-856. Epub 2023 Oct 18. PMID: 37853854

Article Published Date : Jan 31, 2024

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Liver Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

[+]

Horse chestnut contains compounds which inhibit the growth of colon cancer cells. Jun 01, 2006

Click here to read the entire abstract

Pubmed Data : Mol Cancer Ther. 2006 Jun;5(6):1459-66. PMID: 16818504

Article Published Date : Jun 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Colon Cancer

[+]

Inhibition of migration and invasion in melanoma cells.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biol Pharm Bull. 2018 ;41(10):1606-1610. PMID: 30270331

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Melanoma

Pharmacological Actions : Antiproliferative , Apoptotic, NF-kappaB Inhibitor

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Japanese horse chestnuts display antiviral activity against porcine epidemic diarrhea virus of the coronaviridiae family.Jan 01, 2017

Click here to read the entire abstract

Pubmed Data : Bioorg Med Chem Lett. 2017 07 1 ;27(13):3019-3025. Epub 2017 May 8. PMID: 28527823

Article Published Date : Jan 01, 2017

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Coronavirus Disease (Covid-19), Coronavirus Infection

Pharmacological Actions : Antiviral Agents

[+]

Role of escin in breast cancer therapy: potential mechanism for inducing ferroptosis and synergistic antitumor activity with cisplatin.Jul 31, 2023

Click here to read the entire abstract

Pubmed Data : Apoptosis. 2023 Aug ;28(7-8):1154-1167. Epub 2023 May 6. PMID: 37149513

Article Published Date : Jul 31, 2023

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Breast Cancer, Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Apoptotic

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

These results demonstrated that β-escin has apoptotic effects in human cancer cells.Dec 31, 2015

Click here to read the entire abstract

Pubmed Data : Acta Biochim Pol. 2016 ;63(1):79-87. Epub 2016 Jan 27. PMID: 26824290

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Cancers: All

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

This study indicates that Horse chestnut extract could be an effective agent for wound healing in diabetic wound model.Feb 28, 2019

Click here to read the entire abstract

Pubmed Data : J Food Biochem. 2019 Mar ;43(3):e12758. Epub 2019 Jan 3. PMID: 31353546

Article Published Date : Feb 28, 2019

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Wound Healing

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Matrix metalloproteinase-9 (MMP-9) inhibitor

Additional Keywords : Plant Extracts

[+]

β-Aescin at subinhibitory concentration (sub-MIC) enhances susceptibility of Candida glabrata clinical isolates to nystatin.Oct 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Med Mycol. 2015 Nov ;53(8):845-51. Epub 2015 Jun 19. PMID: 26092104

Article Published Date : Oct 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Candida Glabrata

Pharmacological Actions : Antifungal Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

β-Aescin shows potent antiproliferative activity in osteosarcoma cells.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J BUON. 2017 ;22(6):1582-1586. PMID: 29332356

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Osteosarcoma

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

β-Aescin shows potent antiproliferative activity in osteosarcoma cells.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J BUON. 2017 ;22(6):1582-1586. PMID: 29332356

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Osteosarcoma

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

β-escin activates ALDH and prevents cigarette smoke-induced cell death.Dec 31, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2024 Jan ;170:115924. Epub 2023 Nov 28. PMID: 38016364

Article Published Date : Dec 31, 2023

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Smoking

Pharmacological Actions : Anti-Apoptotic

[+]

β-Escin inhibits the proliferation of osteosarcoma cells.Aug 19, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : RSC Adv. 2018 Aug 20 ;8(52):29637-29644. Epub 2018 Aug 21. PMID: 35547316

Article Published Date : Aug 19, 2018

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Osteosarcoma

Pharmacological Actions : Antiproliferative

[+]

β-escin reverses multidrug resistance through inhibition of the GSK3β/β-catenin pathway in cholangiocarcinoma.Jan 27, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Gastroenterol. 2015 Jan 28 ;21(4):1148-57. PMID: 25632187

Article Published Date : Jan 27, 2015

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Cholangiocarcinoma

Pharmacological Actions : Antiproliferative , Chemosensitizer

[+]

β-escin selectively targets the glioblastoma-initiating cell population and reduces cell viability.Oct 10, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2016 Oct 11 ;7(41):66865-66879. PMID: 27589691

Article Published Date : Oct 10, 2016

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Glioblastoma

Pharmacological Actions : Antiproliferative , Apoptotic

Horse Chestnut jQuery(function ($) { $(".node-field-image").click(function () { $(".node-field-image").toggleClass("open"); }); $(".node.topic>.colfull").click(function () { $(".node.topic>.colfull").toggleClass("open"); }); })

Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 73 Abstracts with Horse Chestnut Research

Limited to Members Only

Currently Available Sorting Options

Horse chesnut is an effective and safe treatment for Chronic Venous InsufficiencyJan 01, 2004

Horse chestnut extract exhibits potent anti-aging properties in human skin.Sep 01, 2006

The positive clinical therapeutically effects of Escin on advanced thyroid cancer.Apr 30, 2017

Beta-escin has potent anti-allergic efficacy and reduces allergic airway inflammation.May 20, 2010

Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-κB and nuclear factor-κB-regulated gene products in pancreatic cancer.Apr 30, 2012

Escin induces apoptosis in human bladder cancer cells.Dec 04, 2018

Escin induces caspase-dependent apoptosis and autophagy through the ROS/p38 MAPK signalling pathway in human osteosarcoma cells.Oct 11, 2017

Ameliorative effects of escin on neuropathic pain induced by chronic constriction injury of sciatic nerve.Feb 28, 2021

Anti-inflammatory effects of escin are correlated with the glucocorticoid receptor/NF-κB signaling pathway.Jul 31, 2013

Antiobese effects of novel saponins from edible seeds of Japanese horse chestnut.Jun 24, 2008

Effects of alpha-Escin on mechanical features of the femoral bone in rats with experimental post-steroid osteopenia.Dec 31, 1999

Effects of escin mixture from the seeds of Aesculus hippocastanum on obesity in mice fed a high fat diet.Feb 28, 2010

Effects of escin on acute inflammation and the immune system in mice.Dec 31, 2008

Escin alleviates chemotherapy-induced peripheral neuropathic pain.Nov 29, 2020

Escin alleviates peripheral neuropathy in streptozotocin induced diabetes in rats.Jul 31, 2020

Escin alleviates stress-induced intestinal dysfunction to protect brain injury.Jan 31, 2023

Escin ameliorates the impairments of neurological function and blood brain barrier by inhibiting systemic inflammation in intracerebral hemorrhagic mice.Feb 28, 2021

Escin attenuates acute lung injury induced by endotoxin in mice.Jan 17, 2011

Escin attenuates behavioral impairments, oxidative stress and inflammation in model of Parkinson's disease.Oct 16, 2014

Escin attenuates cognitive deficits and hippocampal injury after transient global cerebral ischemia.Aug 31, 2010

Escin attenuates oxidative damage, apoptosis and lipid peroxidation in a model of cyclophosphamide-induced liver damage.Apr 30, 2022

Escin improves sperm quality in male patients with varicocele-associated infertility.Feb 28, 2010

Escin increases the survival rate of LPS-induced septic mice.Dec 31, 2014

Escin inhibits type I allergic dermatitis in a novel porcine model.Dec 31, 2012

Escin protects against acetaminophen-induced liver injury.Dec 31, 2018

Escin shows extended antioxidant, anti-inflammatory, antinecrotic, and anti-apoptotic effects against Con A-induced immune-mediated hepatitis.Nov 30, 2022

Evaluation of the effect of polyphenol of escin compared with ibuprofen and dexamethasone in synoviocyte model for osteoarthritis.Aug 31, 2018

Horse chestnut extract could significantly protect the concanavalin A-induced acute liver injury.Jul 22, 2019

Horse chestnut seeds had beneficial effects on the functional properties of the kidney and microscopic improvements in diabetic nephropathy.Sep 30, 2016

Horse chestnut. seed extract shows virucidal and antiviral activities against respiratory syncytial virusMar 31, 2019

Influence of alpha-escin on the femoral bone strength in ovariectomized rats.Dec 31, 1998

Protective effects of escin against indomethacin-induced gastric ulcer.Nov 30, 2014

The antinociceptive effect of intrathecal escin in the rat formalin test.Jan 14, 2012

The role of escin as a topical agent for lymphedema treatment.Aug 21, 2023

β-Escin inhibits NNK-induced lung adenocarcinoma.Sep 30, 2013

A review of edible nuts for memory.Dec 31, 2019

Aescin protects neuron from ischemia-reperfusion injury.Dec 31, 2019

Armoracia Rusticana might potentially be used in the amelioration of type 2 diabetes.May 25, 2020

Cytotoxic effects of escin on human castration-resistant prostate cancer cells.Sep 30, 2014

Deciphering the molecular mechanism of escin against neuropathic pain.Dec 31, 2022

Effect of escin alone or in combination with antifungal agents on resistant Candida glabrata biofilms.Jul 19, 2023

Effects of escin on oxidative stress and apoptosis of H9c2 cells induced by H2O2.Dec 31, 2021

Escin alleviates cerebral ischemia-induced intestinal pyroptosis via the GR-dependent p38 MAPK/NF-κB signaling and NLRP3 inflammasome activation.Sep 09, 2024

Escin ameliorates inflammation via inhibiting mechanical stretch and chemically induced Piezo1 activation.Oct 04, 2023

Escin could be used as a novel molecular therapy for pancreatic cancer.Apr 30, 2021

Escin enhanced the efficacy of sorafenib by autophagy-mediated apoptosis in lung cancer cells.Sep 30, 2023

Escin Ia suppresses the metastasis of triple-negative breast cancer.Apr 25, 2016

Escin induces apoptosis in human renal cancer cells.Jan 31, 2017

Escin induces cell death in human skin melanoma cells through apoptotic mechanisms.Jul 31, 2024

Escin inhibits lipopolysaccharide-induced inflammation in human periodontal ligament cells.Oct 31, 2012

Escin mitigates chronic MPTP/p-induced dopaminergic toxicity.Dec 31, 2014

Escin reduces cell proliferation and induces apoptosis on glioma and lung adenocarcinoma cell lines.Sep 30, 2015

Escin sensitized pancreatic cancer cells to chemotherapy.Dec 31, 2012

Escin suppresses HMGB1-induced overexpression of aquaporin-1 and increased permeability in endothelial cells.Apr 30, 2019

Escin suppresses migration and invasion involving the alteration of CXCL16/CXCR6 axis in human gastric adenocarcinoma AGS cells.Dec 31, 2013

Escin's multifaceted therapeutic profile in treatment and post-treatment of vrious cancers.Feb 06, 2023

Escin, a natural mixture of triterpene saponins, exhibits antitumor activity against hepatocellular carcinoma.Nov 30, 2009

Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.Apr 30, 2010

Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells.Sep 30, 2018

Escin-sorafenib synergy up-regulates LC3-II and p62 to induce apoptosis in hepatocellular carcinoma cells.Jan 31, 2024

Horse chestnut contains compounds which inhibit the growth of colon cancer cells. Jun 01, 2006

Inhibition of migration and invasion in melanoma cells.Dec 31, 2017

Japanese horse chestnuts display antiviral activity against porcine epidemic diarrhea virus of the coronaviridiae family.Jan 01, 2017

Role of escin in breast cancer therapy: potential mechanism for inducing ferroptosis and synergistic antitumor activity with cisplatin.Jul 31, 2023

These results demonstrated that β-escin has apoptotic effects in human cancer cells.Dec 31, 2015

This study indicates that Horse chestnut extract could be an effective agent for wound healing in diabetic wound model.Feb 28, 2019

β-Aescin at subinhibitory concentration (sub-MIC) enhances susceptibility of Candida glabrata clinical isolates to nystatin.Oct 31, 2015

β-Aescin shows potent antiproliferative activity in osteosarcoma cells.Dec 31, 2016

β-Aescin shows potent antiproliferative activity in osteosarcoma cells.Dec 31, 2016

β-escin activates ALDH and prevents cigarette smoke-induced cell death.Dec 31, 2023

β-Escin inhibits the proliferation of osteosarcoma cells.Aug 19, 2018

β-escin reverses multidrug resistance through inhibition of the GSK3β/β-catenin pathway in cholangiocarcinoma.Jan 27, 2015

Horse Chestnut

View the Evidence:
73 Abstracts with Horse Chestnut Research