Hydroxytyrosol

Name	AC	CK
Nonalcoholic fatty liver disease (NAFLD)	5	25
Breast Cancer	4	13
Cardiovascular Diseases	4	13
Lipopolysaccharide-Induced Toxicity	8	13
High Fat Diet	6	12
Inflammation	8	11
Atherosclerosis	1	10
Candidiasis: Vulvovaginal	1	10
Upper Respiratory Infections	1	10
Obesity	5	9
Oxidative Stress	7	9
HIV Infections	3	7
Cancers: All	6	6
Insulin Resistance	3	6
Liver Steatosis	3	6
Parkinson's Disease	4	6
Alzheimer's Disease	3	5
Fibromyalgia	1	5
DNA damage	3	4
Liver Damage	2	4
Brain Inflammation	2	3
Colon Cancer	3	3
Neurodegenerative Diseases	3	3
Air Pollution Linked Toxicity	1	2
Arsenic Poisoning	1	2
Asthma	1	2
Athletic Performance	1	2
Bisphenol Toxicity	1	2
Bisphenol-A Toxicity	1	2
Breast Cancer: Triple Negative	2	2
Chemically-Induced Liver Damage	1	2
Cholesterol: LDL/HDL ratio	1	2
Cholesterol: Oxidation	2	2
Cognitive Decline/Dysfunction	1	2
Colitis	1	2
Diabetes Mellitus: Type 1	1	2
Diabetes Mellitus: Type 2	2	2
Diabetes: Oxidative Stress	1	2
Diabetic Complications	1	2
Diabetic Retinopathy	1	2
Glioma	2	2
Hyperlipidemia	1	2
Infants: Low Birth Weight	1	2
Ischemia	1	2
Kidney Damage	1	2
Kidney Damage: Chemically-Induced	1	2
Lung Injury: Acute	1	2
Mastitis	1	2
Metabolic Syndrome X	2	2
Mycotoxin Toxicity	1	2
Myocardial Infarction	1	2
Myocardial Ischemia	1	2
Pancreatitis	1	2
Sepsis	1	2
Stroke: Ischemic	1	2
Triglycerides: Elevated	1	2
Wound Healing	2	2
Acquired Immunodeficiency Syndrome	1	1
Arteriosclerosis	1	1
Blue Light Toxicity	1	1
Brain: Oxidative Stress	1	1
Colorectal Cancer	1	1
Coronavirus Infection	1	1
Endothelial Dysfunction	1	1
High Homocysteine	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Lymphedema	1	1
Melanoma	1	1
Mercury Poisoning	1	1
Mitochondrial Dysfunction	1	1
Multiple Sclerosis	1	1
Mycobacterium Infections	1	1
Osteoarthritis	1	1
Osteoporosis	1	1
Pancreatic Cancer	1	1
Prostate Cancer	1	1
Rheumatoid Arthritis	1	1
Vibrio Infections	1	1

Name	AC	CK
Anti-Inflammatory Agents	33	79
Antioxidants	35	68
Hepatoprotective	11	37
Neuroprotective Agents	13	21
Tumor Necrosis Factor (TNF) Alpha Inhibitor	7	20
Interleukin-6 Downregulation	3	14
Anti-atherogenic	1	10
Antifungal Agents	1	10
Interleukin-10 upregulation	1	10
NF-kappaB Inhibitor	6	10
Anti-Apoptotic	5	9
Antiproliferative	8	8
Cardioprotective	5	7
Autophagy Up-regulation	4	6
Gastrointestinal Agents	3	6
Hypolipidemic	4	6
Renoprotective	3	6
Anti-Retroviral Agents	1	5
Apoptotic	5	5
Cyclooxygenase 2 Inhibitors	3	5
Chemotherapeutic	4	4
Interleukin-1 beta downregulation	2	4
Nrf2 activation	3	4
Anti-metastatic	3	3
Hypoglycemic Agents	2	3
Antineoplastic Agents	2	2
Antiviral Agents	2	2
Cell cycle arrest	2	2
Chemopreventive	2	2
Gastroprotective	1	2
Neurogenesis	1	2
Vascular Cell Adhesion Molecule-1 Inhibitor	2	2
Anti-Bacterial Agents	1	1
Antimicrobial	1	1
Antimycobacterial	1	1
Autophagy Inhibitors	1	1
Chondroprotective	1	1
Cytoprotective	1	1
Epidermal growth factor receptor (EGFR) inhibitor	1	1
Genoprotective	1	1
HIV Fusion Inhibitors	1	1
HIV-1 Integrase Inhibitor	1	1
Insulin Sensitizers	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1
MicroRNA modulator	1	1
Pancreato Protective Agents	1	1
Photoprotective	1	1
Proteasome Inhibitors	1	1
SIRT1 Activator	1	1
Topoisomerase II Inhibitor	1	1

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Malondialdehyde Down-regulation

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Hydroxytyrosol changed body composition parameters and modulated the antioxidant profile, the expression of inflammation and oxidative stress-related genes.Dec 31, 2016

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Pubmed Data : Nutrients. 2022 Apr 29 ;14(9). Epub 2022 Apr 29. PMID: 35565844

Article Published Date : Apr 28, 2022

Study Type : Human Study

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Substances : Hydroxytyrosol, Punicalagin

Diseases : Dyslipidemias

Pharmacological Actions : Cardioprotective, Gastrointestinal Agents, Hypolipidemic

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Supplementation with hydroxytyrosol and punicalagin improves early atherosclerosis markers.Mar 15, 2019

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Biochemical evaluation of the antioxidant effects of hydroxytyrosol on pancreatitis-associated gut injury.Aug 21, 2020

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Pubmed Data : Antioxidants (Basel). 2020 Aug 22 ;9(9). Epub 2020 Aug 22. PMID: 32842687

Article Published Date : Aug 21, 2020

Study Type : Animal Study

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Substances : Hydroxytyrosol

Diseases : Pancreatitis

Pharmacological Actions : Gastroprotective

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Combined hydroxytyrosol and eicosapentaenoic acid drastically decreases NAFLD development.Dec 31, 2017

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Pubmed Data : Biol Pharm Bull. 2019 ;42(7):1120-1127. PMID: 31257288

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Hydroxytyrosol

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Gastrointestinal Agents

Problem Substances : Aspirin

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Protective effect of hydroxytyrosol against oxidative stress induced by the ochratoxin in kidney cells.Dec 31, 2019

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Pubmed Data : Front Vet Sci. 2020 ;7:136. Epub 2020 Mar 31. PMID: 32296717

Article Published Date : Dec 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Hydroxytyrosol

Diseases : Kidney Damage: Chemically-Induced, Mycotoxin Toxicity

Pharmacological Actions : Antioxidants, Renoprotective

Problem Substances : Ochratoxin A

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Protective effect of hydroxytyrosol against oxidative stress mediated by arsenic-induced neurotoxicity in rats.Mar 01, 2018

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Pubmed Data : Appl Biochem Biotechnol. 2018 Mar 2. Epub 2018 Mar 2. PMID: 29497947

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Pubmed Data : Antioxidants (Basel). 2022 Jul 27 ;11(8). Epub 2022 Jul 27. PMID: 36009185

Article Published Date : Jul 26, 2022

Study Type : Animal Study

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Substances : Hydroxytyrosol

Diseases : Coronavirus Infection

Pharmacological Actions : Antioxidants

Additional Keywords : Long Covid

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Pubmed Data : Acta Pharm. 2021 Mar 1 ;71(1):131-141. PMID: 32697745

Article Published Date : Feb 28, 2021

Study Type : In Vitro Study

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Substances : Hydroxytyrosol, Oleuropein

Diseases : DNA damage, Hydrogen Peroxide Induced Toxicity

Pharmacological Actions : Genoprotective

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"Naturally occurring hydroxytyrosol: synthesis and anticancer potential."Nov 18, 2012

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Pubmed Data : Curr Med Chem. 2012 Nov 19. Epub 2012 Nov 19. PMID: 23244583

Article Published Date : Nov 18, 2012

Study Type : Review

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Substances : Hydroxytyrosol

Diseases : Cancers: All

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A Mediterranean diet may protect against homocysteine-induced cardiovascular damage. Sep 01, 2010

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Pubmed Data : Chemosphere. 2010 Sep;81(4):464-8. PMID: 17586618

Article Published Date : Sep 01, 2010

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Pubmed Data : Acta Biomed. 2020 11 9 ;91(13-S):e2020007. Epub 2020 Nov 9. PMID: 33170159

Article Published Date : Jan 08, 2020

Study Type : Review

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Substances : Hydroxytyrosol, Palmitoylethanolamide

Diseases : Brain Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

Additional Keywords : Plant Extracts

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HIDROX-containing cream can be applied topically as an antiviral hand cream.Jan 01, 2021

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Pubmed Data : J Vet Med Sci. 2018 Dec 11 ;80(12):1801-1807. Epub 2018 Oct 5. PMID: 30298817

Article Published Date : Dec 10, 2018

Study Type : In Vitro Study

Additional Links

Substances : Hydroxytyrosol

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

Additional Keywords : Plant Extracts

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Hydroxytyrosol restores proper insulin signaling in an astrocytic model of Alzheimer's disease.Jul 07, 2017

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Pubmed Data : Int J Mol Sci. 2018 Jul 2 ;19(7). Epub 2018 Jul 2. PMID: 30004416

Article Published Date : Jul 01, 2018

Study Type : In Vitro Study

Additional Links

Substances : Hydroxytyrosol, Oleuropein

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Selective Antiproliferation

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Oleuropein and hydroxytyrosol, two polyphenols contianed within extra-virgin olive oil, inhibit MCF-7 breast cancer cell proliferation. Dec 10, 2009

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Pubmed Data : Mol Nutr Food Res. 2009 Dec 10. PMID: 20013881

Article Published Date : Dec 10, 2009

Study Type : In Vitro Study

Additional Links

Substances : Hydroxytyrosol, Oleuropein, Olive, Olive Oil, Polyphenols

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Chemopreventive

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Oleuropein may represent a novel therapeutic approach against glioblastoma cells.Feb 07, 2023

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Pubmed Data : Life (Basel). 2023 Feb 8 ;13(2). Epub 2023 Feb 8. PMID: 36836827

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Pubmed Data : Biotechnol Bioeng. 2020 Sep 5. Epub 2020 Sep 5. PMID: 32889748

Article Published Date : Sep 04, 2020

Study Type : In Vitro Study

Additional Links

Substances : Hydroxytyrosol, Quercetin

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants, Hepatoprotective, Hypolipidemic

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Resveratrol, tyrosol and hydroxytyrosol may have therapeutic value in multiple sclerosis. Mar 01, 2011

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Pubmed Data : Neurochem Res. 2011 Mar;36(3):518-27. Epub 2011 Jan 5. PMID: 21207142

Article Published Date : Mar 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Hydroxytyrosol, Resveratrol, Tyrosol

Diseases : Multiple Sclerosis

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Click here to read the entire abstract

Pubmed Data : Pharmacol Res. 2019 May ;143:58-72. Epub 2019 Mar 7. PMID: 30853597

Article Published Date : Apr 30, 2019

Study Type : Review

Additional Links

Substances : Hydroxytyrosol

Diseases : Cancers: All, Metabolic Syndrome X, Neurodegenerative Diseases, Osteoporosis

Pharmacological Actions : Antioxidants

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Wide biological role of hydroxytyrosol: possible therapeutic and preventive properties in cardiovascular diseases.Aug 20, 2020

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Pubmed Data : Cells. 2020 Aug 21 ;9(9). Epub 2020 Aug 21. PMID: 32825589

Article Published Date : Aug 20, 2020

Study Type : Review

Additional Links

Substances : Hydroxytyrosol

Diseases : Cardiovascular Diseases

Pharmacological Actions : Cardioprotective

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View the Evidence: 130 Abstracts with Hydroxytyrosol Research

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A combination of hydroxytyrosol, omega-3 fatty acids and curcumin improves pain and inflammation among early stage breast cancer patients.Mar 31, 2019

Antioxidant activity of hydroxytyrosol and vitamin E reduces systemic inflammation in children with paediatric NAFLD.Oct 11, 2020

Association of hydroxytyrosol enriched olive oil with vascular function in chronic coronary disease.Jun 30, 2023

Hydroxytyrosol changed body composition parameters and modulated the antioxidant profile, the expression of inflammation and oxidative stress-related genes.Dec 31, 2016

Hydroxytyrosol is effective and safe in preventing recurrent candida episodes.Jun 30, 2020

Olive leaf extract has a beneficial effects on upper respiratory illness in high school athletes. Feb 08, 2019

Oral supplement containing hydroxytyrosol and punicalagin improves dyslipidemia.Apr 28, 2022

Supplementation with hydroxytyrosol and punicalagin improves early atherosclerosis markers.Mar 15, 2019

Vitamin E and hydroxytyrosol may be a promising strategy that could be easily diet integrated to improve NAFLD-related liver damage in children.Feb 10, 2019

5-Hydroxytyrosol inhibits HIV-1 replication in primary cells of the lower and upper female reproductive tract.Dec 31, 2016

Hydroxytyrosol as a promising ally in the treatment of fibromyalgia.Aug 08, 2020

Combination treatment with hydroxytyrosol and vitamin E improves NAFLD-related fibrosis.Sep 13, 2022

Hydroxytyrosol ameliorates oxidative challenge and inflammatory response associated with lipopolysaccharide-mediated sepsis.Aug 24, 2020

Administration of olive leaf and hydroxytyrosol extracts significantly improved the antioxidant state in asthma disease.Oct 22, 2019

Anti-inflammatory and anti-oxidant activity of Hidroxin in rotenone-induced Parkinson's disease.Sep 02, 2020

Biochemical evaluation of the antioxidant effects of hydroxytyrosol on pancreatitis-associated gut injury.Aug 21, 2020

Combined hydroxytyrosol and eicosapentaenoic acid drastically decreases NAFLD development.Dec 31, 2017

Combined treatment of hydroxytyrosol, oleic acid and n-3 fatty acids exhibit huge therapeutic benefits in colitis.Mar 22, 2016

Diet supplementation with hydroxytyrosol ameliorates brain pathology and restores cognitive functions in a mouse model of amyloid-β deposition.Apr 24, 2018

Docosahexaenoic acid and hydroxytyrosol co-administration fully prevents liver steatosis.Aug 26, 2019

Effects of hydroxytyrosol dose on the redox status of exercised rats.Dec 31, 2017

Hydroxtyrosol has antioxidant and lipid-lowering effects in cholesterol-fed rats. Apr 23, 2008

Hydroxytyrosol acetate improves the cognitive function of APP/PS1 transgenic mice in ERβ-dependent manner.Dec 08, 2020

Hydroxytyrosol alleviate intestinal inflammation, oxidative stress and apoptosis resulted in ulcerative colitis.Sep 30, 2021

Hydroxytyrosol alleviates dextran sodium sulfate-induced colitis.Dec 25, 2021

Hydroxytyrosol alleviates oxidative stress and neuroinflammation and enhances hippocampal neurotrophic signaling.May 16, 2021

Hydroxytyrosol ameliorates insulin resistance by modulating endoplasmic reticulum stress and prevents hepatic steatosis in diet-induced obesity.Jun 30, 2018

Hydroxytyrosol ameliorates intervertebral disc degeneration and neuropathic pain.Dec 31, 2021

Hydroxytyrosol and olive leaf extract exert cardioprotective effects by inhibiting GRP78 and CHOP expression.Dec 31, 2016

Hydroxytyrosol as anti-parkinsonian molecule.Apr 17, 2021

Hydroxytyrosol attenuates ethanol-induced liver injury.Nov 30, 2023

Hydroxytyrosol attenuates hepatic fat accumulation.Sep 01, 2020

Hydroxytyrosol attenuates LPS-induced acute lung injury in mice by regulating autophagy and sirtuin expression.Dec 31, 2016

Hydroxytyrosol exerted a neuroprotective effect on diabetic retinopathy.Jan 23, 2018

Hydroxytyrosol improves obesity and insulin resistance by modulating gut microbiota.Dec 31, 2018

Hydroxytyrosol influences exercise-induced mitochondrial respiratory complex assembly into supercomplexes in rats.Jan 23, 2019

Hydroxytyrosol inhibits apoptosis in ischemia/reperfusion-induced acute kidney injury.Nov 30, 2020

Hydroxytyrosol may reduce the liver alterations induced in high fat diet-fed mice.Apr 18, 2017

Hydroxytyrosol prevents fine particular matter-induced adiposity and insulin resistance.Aug 31, 2019

Hydroxytyrosol protects against myocardial ischemia reperfusion injury.Dec 31, 2018

Hydroxytyrosol reduces foam cell formation and endothelial inflammation. Jan 19, 2023

Hydroxytyrosol represents an interesting molecule for the development of new nutraceuticals and functional food useful in chronic diseases prevention.Dec 04, 2018

Hydroxytyrosol stimulates neurogenesis in aged dentate gyrus by enhancing stem and progenitor cell proliferation and neuron survival.Feb 05, 2020

Hydroxytyrosol suppresses LPS-induced intrahepatic inflammatory responses.May 31, 2020

Hydroxytyrosol-enriched diet could serve as a beneficial therapeutic approach to attenuate ischemic stroke-associated damage.Oct 10, 2019

Insight into the molecular mechanism underlying the inhibition of α-synuclein aggregation by hydroxytyrosol.Nov 18, 2019

Nephroprotective effect of the virgin olive oil polyphenol hydroxytyrosol in type 1-like experimental diabetes mellitus.Nov 07, 2021

Oleuropein and hydroxytyrosol exhibit anti-diabetic and antioxidant actions. Oct 14, 2009

Oleuropein and hydroxytyrosol-rich olive leaf extracts possessed hypolipidemic and hepatoprotective effects against HFD-induced metabolic disorders.Dec 31, 2019

Olive leaf extracts possess hypolipidemic and hepatoprotective effects against BPA-induced metabolic disorders.May 20, 2018

Olive-derived hydroxytyrosol shows anti-inflammatory effect without gastric damage in rats.Dec 31, 2018

Protective effect of hydroxytyrosol against oxidative stress induced by the ochratoxin in kidney cells.Dec 31, 2019

Protective effect of hydroxytyrosol against oxidative stress mediated by arsenic-induced neurotoxicity in rats.Mar 01, 2018

Reduction of high-fat diet-induced liver proinflammatory state by eicosapentaenoic acid plus hydroxytyrosol supplementation.Dec 31, 2018

Role of hydroxytyrosol and oleuropein in the prevention of aging and related disorders.Apr 03, 2023

SARS-CoV-2 PLpro remaining in host cells after viral clearance may contribute to the pathogenetic mechanisms of long-COVID.Jul 26, 2022

Supplementation with hydroxytyrosol improve the WAT dysfunction induced by high-fat diet.Dec 31, 2018

The present study demonstrates the hepato-protective and reno-protective effects of oleuropein and hydroxytyrosol olive leaves extracts from BPA and its derivates toxicity.May 07, 2015

Therapeutic prospects of hydroxytyrosol on experimentally induced diabetic testicular damage: potential interplay with AMPK expression.Dec 13, 2019

These findings suggest that maternal supplementation with hydroxytyrosol may improve juvenile development of offspring in at-risk pregnancies.Nov 07, 2019

These results indicate that nutritional consumption of Hidrox can be considered as a new therapeutic approach for human fibromyalgia.Nov 12, 2021

These results indicated a possible important therapeutic role for hydroxytyrosol in the prevention or management of bovine mastitis.Aug 02, 2020

Extrapolation of hydroxytyrosol and its analogues as potential anti-inflammatory agents.Jul 15, 2020

Protective effects of olive oil phenolics oleuropein and hydroxytyrosol against hydrogen peroxide-induced DNA damage in human peripheral lymphocytes.Feb 28, 2021

"Naturally occurring hydroxytyrosol: synthesis and anticancer potential."Nov 18, 2012

A Mediterranean diet may protect against homocysteine-induced cardiovascular damage. Sep 01, 2010

A review of emerging trends in potential therapeutic applications of hydroxytyrosol.May 20, 2018

A review of hydroxytyrosol in the prevention of the metabolic syndrome and related disorders.Mar 19, 2017

A review of natural antioxidants in the management of Parkinson's disease.Mar 26, 2021

Anti-inflammatory and antitumor effects of hydroxytyrosol.Jan 25, 2018

Effects of extra virgin olive oil polyphenols on beta-cell function and survival.Feb 02, 2021

Effects of hydroxytyrosol in endothelial functioning.Feb 15, 2023

Hydroxytyrosol

View the Evidence:
130 Abstracts with Hydroxytyrosol Research