Icariin

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13 Diseases Researched for Icariin
NameACCKFocus
Oxidative Stress24Locked
Stroke23Locked
Aging12Locked
Aging: Brain 12Locked
Aluminum Toxicity 12Locked
Cognitive Decline/Dysfunction12Locked
Learning disorders12Locked
Memory Disorders12Locked
Alzheimer's Disease11Locked
Brain Ischemia11Locked
Liver Cancer11Locked
Neurodegenerative Diseases11Locked
Osteoporosis11Locked
3 Pharmacological Actions Researched for Icariin
NameACCKFocus
Neuroprotective Agents46Locked
Antioxidants12Locked
Apoptotic11Locked

View the Evidence:
123 Abstracts with Icariin Research

[+]

Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization.Mar 17, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Redox Biol. 2022 Mar 18 ;52:102297. Epub 2022 Mar 18. PMID: 35334248
Article Published Date : Mar 17, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Icariin
Diseases : Uveitis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Icariin ameliorates endothelial dysfunction in type 1 diabetes.Dec 31, 2020

Pubmed Data : J Cell Physiol. 2021 03 ;236(3):1889-1902. Epub 2020 Aug 7. PMID: 32770555
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Diabetes Mellitus: Type 1, Endothelial Dysfunction
Pharmacological Actions : Antioxidants
[+]

Icariin attenuates renal fibrosis in vivo and in vitro by inhibiting the Notch2/Hes-1 pathway.Apr 14, 2022

Pubmed Data : Growth Factors. 2022 Apr 15:1-11. Epub 2022 Apr 15. PMID: 35426327
Article Published Date : Apr 14, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Icariin
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Icariin exhibits protective effects on cisplatin-induced cardiotoxicity.Aug 31, 2022

Pubmed Data : Phytomedicine. 2022 Sep ;104:154331. Epub 2022 Jul 10. PMID: 35878553
Article Published Date : Aug 31, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Icariin
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents
[+]

Icariin inhibits the malignant progression of lung cancer.May 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2022 Jun ;47(6). Epub 2022 May 6. PMID: 35514319
Article Published Date : May 31, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Icariin
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, MicroRNA modulator
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Multifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer's disease.Nov 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Deliv. 2022 Dec ;29(1):1648-1662. PMID: 35616263
Article Published Date : Nov 30, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Icariin, Tanshinone IIA
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

A phytomolecule icariin protects from sarcopenia.Nov 30, 2022

Pubmed Data : Adv Biol (Weinh). 2022 Dec ;6(12):e2200162. Epub 2022 Aug 26. PMID: 36026561
Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Sarcopenia
Pharmacological Actions : MicroRNA modulator
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Cardioprotective effect of icariin against myocardial fibrosis and its molecular mechanism in diabetic cardiomyopathy.Sep 30, 2021

Pubmed Data : Phytomedicine. 2021 Oct ;91:153607. Epub 2021 May 24. PMID: 34411833
Article Published Date : Sep 30, 2021
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Cardiomyopathy, Diabetes Mellitus: Type 2, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Effect of icariin in a rat model of colchicine-induced cognitive deficit: role of β - amyloid proteolytic enzymes.Nov 06, 2022

Pubmed Data : Nutr Neurosci. 2022 Nov 7:1-11. Epub 2022 Nov 7. PMID: 36342068
Article Published Date : Nov 06, 2022
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
[+]

Effects of icariin on alleviating schizophrenia-like symptoms.Nov 19, 2022

Pubmed Data : Neurosci Lett. 2022 Nov 20 ;791:136918. Epub 2022 Oct 17. PMID: 36261079
Article Published Date : Nov 19, 2022
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Schizophrenia
Pharmacological Actions : Anti-Apoptotic, MicroRNA modulator, Neuroprotective Agents
[+]

Effects of icariin on modulating gut microbiota and regulating metabolite alterations to prevent bone loss in ovariectomized rat model.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Endocrinol (Lausanne). 2022 ;13:874849. Epub 2022 Mar 24. PMID: 35399950
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Osteoporosis: Age-Related
Pharmacological Actions : Gastrointestinal Agents, Osteoprotective
[+]

Exploration of the effect of icariin on nude mice with lung cancer bone metastasis.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Comput Math Methods Med. 2022 ;2022:2011625. Epub 2022 May 28. PMID: 35669373
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Cancer Metastasis, Lung Cancer
Pharmacological Actions : Anti-Cachexic Agents, Anti-metastatic
[+]

Icariin alleviates Escherichia coli lipopolysaccharide-mediated endometritis.Sep 05, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2022 Sep 6 ;23(18). Epub 2022 Sep 6. PMID: 36142129
Article Published Date : Sep 05, 2022
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Endometritis, Escherichia coli Infections, Inflammation, Lipopolysaccharide-Induced Toxicity, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-10 downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Icariin alleviates glucocorticoid-induced osteoporosis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:2982480. Epub 2020 May 17. PMID: 32508946
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
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Icariin alleviates nonalcoholic fatty liver disease in polycystic ovary syndrome.Jan 04, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2023 Jan 5 ;28(2). Epub 2023 Jan 5. PMID: 36677577
Article Published Date : Jan 04, 2023
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Nonalcoholic fatty liver disease (NAFLD), Polycystic Ovary Syndrome
Pharmacological Actions : Antioxidants, Hepatoprotective, Hypolipidemic
[+]

Icariin ameliorates Alzheimer's disease pathology.Mar 31, 2022

Pubmed Data : Neurochem Res. 2022 Apr ;47(4):1049-1059. Epub 2022 Jan 17. PMID: 35037164
Article Published Date : Mar 31, 2022
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Alzheimer's Disease, Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
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Icariin ameliorates diabetic cardiomyopathy.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:256. Epub 2020 Mar 19. PMID: 32265695
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Cardiomyopathy, Diabetic Complications
Pharmacological Actions : Cardioprotective
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Icariin ameliorates diabetic renal tubulointerstitial fibrosis.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:720387. Epub 2021 Jul 19. PMID: 34349660
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Fibrotic, Autophagy Up-regulation, MicroRNA modulator, Renoprotective
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Icariin ameliorates learning and memory impairments.Aug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Sep ;117:109077. Epub 2019 Jun 6. PMID: 31177064
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Learning disorders, Memory Disorders
Pharmacological Actions : Neuroprotective Agents
[+]

Icariin ameliorates lower back pain.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2020 ;2020:4670604. Epub 2020 Aug 5. PMID: 32802846
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Hyperalgesia, Low Back Pain
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
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Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2023 Jan ;18(1):183-188. PMID: 35799540
Article Published Date : Dec 31, 2022
Study Type : Transgenic Animal Study
Additional Links
Substances : Icariin
Diseases : Memory Disorders
Pharmacological Actions : Neuroprotective Agents
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Icariin ameliorates metabolic syndrome-induced benign prostatic hyperplasia in rats.Feb 28, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Sci Pollut Res Int. 2022 Mar ;29(14):20370-20378. Epub 2021 Nov 4. PMID: 34734339
Article Published Date : Feb 28, 2022
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Metabolic Diseases, Prostatic Hyperplasia: Benign
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
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Icariin ameliorates streptozocin-induced diabetic nephropathy through suppressing the TLR4/NF-κB signal pathway.Feb 14, 2021

Pubmed Data : Food Funct. 2021 Feb 15 ;12(3):1241-1251. PMID: 33433547
Article Published Date : Feb 14, 2021
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
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Icariin ameliorates the cognitive function in an epilepsy neonatal rat model.Dec 31, 2019

Pubmed Data : Folia Neuropathol. 2020 ;58(3):245-252. PMID: 33099294
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Brain: Oxidative Stress, Epilepsy
Pharmacological Actions : Anti-Apoptotic, Anticonvulsants, Neuroprotective Agents
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Icariin ameliorates the progression of experimental autoimmune encephalomyelitis.Oct 14, 2020

Pubmed Data : Eur J Pharmacol. 2020 Oct 15 ;885:173523. Epub 2020 Aug 29. PMID: 32871176
Article Published Date : Oct 14, 2020
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Brain Inflammation , Multiple Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents
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Icariin and competing endogenous RNA network: A potential protective strategy against contrast-induced acute kidney injury.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2022 ;16:2343-2363. Epub 2022 Jul 23. PMID: 35910780
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Kidney Damage
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Renoprotective
[+]

Icariin attenuates bleomycin-induced pulmonary fibrosis by targeting Hippo/YAP pathway.Oct 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2021 Nov ;143:112152. Epub 2021 Sep 15. PMID: 34536758
Article Published Date : Oct 31, 2021
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents
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Icariin attenuates cyclophosphamide-induced cystitis.Apr 30, 2022

Pubmed Data : Int Immunopharmacol. 2022 May ;106:108604. Epub 2022 Feb 8. PMID: 35149295
Article Published Date : Apr 30, 2022
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Cystitis
Pharmacological Actions : Chemoprotective Agents, NF-kappaB Inhibitor
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Icariin attenuates ischemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signaling pathway in rats.Apr 21, 2022

Pubmed Data : Clin Exp Pharmacol Physiol. 2022 Apr 22. Epub 2022 Apr 22. PMID: 35451526
Article Published Date : Apr 21, 2022
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Stroke: Ischemic
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents
[+]

Icariin attenuates monocrotaline-induced pulmonary arterial hypertension.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:9238428. Epub 2020 Dec 1. PMID: 33335559
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents, Transforming growth factor beta (TGF-β) inhibitor
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Icariin attenuates perfluorooctane sulfonate-induced testicular toxicity.Mar 20, 2022

Pubmed Data : Food Funct. 2022 Mar 21 ;13(6):3674-3689. Epub 2022 Mar 21. PMID: 35262540
Article Published Date : Mar 20, 2022
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Matrix metalloproteinase-9 (MMP-9) inhibitor
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Icariin attenuates the tumor growth by targeting miR-1-3p/TNKS2/Wnt/β-catenin signaling axis in ovarian cancer.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Oncol. 2022 ;12:940926. Epub 2022 Sep 14. PMID: 36185280
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative
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Icariin attenuates thioacetamide‑induced bone loss via the RANKL‑p38/ERK‑NFAT signaling pathway.Mar 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2022 Apr ;25(4). Epub 2022 Feb 16. PMID: 35169865
Article Published Date : Mar 31, 2022
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
[+]

Icariin enhances AMP-activated protein kinase and prevents high fructose and high salt-induced metabolic syndrome.Oct 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi Pharm J. 2020 Nov ;28(11):1309-1316. Epub 2020 Sep 2. PMID: 33250640
Article Published Date : Oct 31, 2020
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : High Fructose Diet, Metabolic Syndrome X
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Icariin enhances youth-like features by attenuating the declined gut microbiota in the aged mice.Dec 31, 2020

Pubmed Data : Pharmacol Res. 2021 06 ;168:105587. Epub 2021 Mar 31. PMID: 33798737
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Aging
Pharmacological Actions : Gastrointestinal Agents
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Icariin has a neuroprotective effect on memory impairment and neurochemical deficits in age-acceleration prone mice.Jun 02, 2010

Pubmed Data : Brain Res. 2010 Jun 2;1334:73-83. Epub 2010 Apr 7. PMID: 20380820
Article Published Date : Jun 02, 2010
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Aging, Aging: Brain , Cognitive Decline/Dysfunction, Memory Disorders, Oxidative Stress
Pharmacological Actions : Neuroprotective Agents
[+]

Icariin has a synergistic effect on the osteoinductivity of bone morphogenetic protein 2 at ectopic sites.Jan 09, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Orthop Surg. 2023 Jan 10. Epub 2023 Jan 10. PMID: 36628510
Article Published Date : Jan 09, 2023
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Bone Diseases
Pharmacological Actions : Osteoprotective
[+]

Icariin improves brain function decline in aging rats.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2021 Dec ;59(1):183-191. PMID: 33556283
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Aging
Pharmacological Actions : Neuroprotective Agents
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Icariin improves cognitive deficits by reducing the deposition of β-amyloid peptide and inhibition of neurons apoptosis.Jan 06, 2020

Pubmed Data : Neuroreport. 2020 06 7 ;31(9):663-671. PMID: 32427716
Article Published Date : Jan 06, 2020
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Icariin improves cutaneous wound healing in streptozotocin-induced diabetes.Jan 31, 2022

Pubmed Data : J Tissue Viability. 2022 Feb ;31(1):197-206. Epub 2021 Sep 21. PMID: 34565677
Article Published Date : Jan 31, 2022
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Diabetic Complications, Wound Healing: Delayed
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
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Icariin improves erectile function in spontaneously hypertensive rats by up-regulating Nrf2.Jan 31, 2021

Pubmed Data : Zhonghua Nan Ke Xue. 2021 Feb ;27(2):106-113. PMID: 34914325
Article Published Date : Jan 31, 2021
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Erectile Dysfunction, Hypertension
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Icariin improves glucocorticoid resistance in a murine model of asthma with depression.Aug 21, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Planta Med. 2022 Aug 22. Epub 2022 Aug 22. PMID: 35850481
Article Published Date : Aug 21, 2022
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Asthma, Depression
Pharmacological Actions : Anti-Inflammatory Agents
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Icariin improves renal interstitial fibrosis in a rat model of chronic renal failure.Mar 31, 2022

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2022 Apr ;47(8):2170-2177. PMID: 35531733
Article Published Date : Mar 31, 2022
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Fibrosis, Kidney Failure: Chronic
Pharmacological Actions : Anti-Fibrotic, Gastroprotective
[+]

Icariin improves the cognitive function of APP/PS1 mice via suppressing endoplasmic reticulum stress.Sep 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Life Sci. 2019 Oct 1 ;234:116739. Epub 2019 Aug 7. PMID: 31400352
Article Published Date : Sep 30, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Icariin inhibits intestinal inflammation of DSS-induced colitis.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Turk J Gastroenterol. 2021 04 ;32(4):382-392. PMID: 34231485
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Colitis, Inflammation, Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Icariin inhibits the formation of mitochondria-associated membranes (MAMs) and improves erectile function in rats treated with prostate radiation.Aug 31, 2022

Pubmed Data : Andrology. 2022 Sep ;10(6):1208-1216. Epub 2022 Jul 11. PMID: 35765205
Article Published Date : Aug 31, 2022
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Erectile Dysfunction, Radiation
Pharmacological Actions : Radioprotective
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Icariin may accelerate fracture healing by activating the BMP-2/Smad5/Runx2 pathway.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2021 Dec ;59(1):1245-1255. PMID: 34511043
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Fractures: Bone
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Icariin may exert as a protector in type 2 diabetes mellitus-induced diabetic cardiomyopathy.Dec 31, 2019

Pubmed Data : Pharmacology. 2020 ;105(9-10):576-585. Epub 2020 Feb 25. PMID: 32097949
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Cardiomyopathy, Diabetes Mellitus: Type 2
Pharmacological Actions : Cardioprotective
[+]

Icariin modulates eNOS activity via effect on post-translational protein-protein interactions to improve erectile functio.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Andrology. 2021 01 ;9(1):342-351. Epub 2020 Aug 9. PMID: 33507631
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Erectile Dysfunction, Hypertension
Additional Keywords : Phytotherapy
[+]

Icariin protects against against learning and memory deficits induced by aluminium in rats.Aug 01, 2007

Pubmed Data : Clin Exp Pharmacol Physiol. 2007 Aug;34(8):792-5. PMID: 17600559
Article Published Date : Aug 01, 2007
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Aluminum Toxicity , Learning disorders, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Icariin protects against brain injury in an experimental model of stroke.Jul 01, 2010

Pubmed Data : Neuropharmacology. 2010 Jul-Aug;59(1-2):70-6. Epub 2010 Apr 8. PMID: 20381504
Article Published Date : Jul 01, 2010
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Stroke
Pharmacological Actions : Neuroprotective Agents
[+]

Icariin protects podocytes from NLRP3 activation by Sesn2-induced mitophagy through the Keap1-Nrf2/HO-1 axis in diabetic nephropathy.Feb 26, 2022

Pubmed Data : Phytomedicine. 2022 Feb 27 ;99:154005. Epub 2022 Feb 27. PMID: 35247669
Article Published Date : Feb 26, 2022
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Renoprotective
[+]

Icariin protects rotenone-induced neurotoxicity through induction of SIRT3.Jan 14, 2019

Pubmed Data : Toxicol Appl Pharmacol. 2019 09 15 ;379:114639. Epub 2019 Jun 25. PMID: 31251943
Article Published Date : Jan 14, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Neurodegenerative Diseases, Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Superoxide Dismutase Up-regulation
Problem Substances : Rotenone
[+]

Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:937502. Epub 2022 Sep 13. PMID: 36176424
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Antioxidants, Chondroprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Icariin reduces LPS-induced acute lung injury in mice undergoing bilateral adrenalectomy by regulating GRα.Jun 04, 2020

Pubmed Data : Eur J Pharmacol. 2020 Jun 5 ;876:173032. Epub 2020 Mar 5. PMID: 32147435
Article Published Date : Jun 04, 2020
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Icariin treatment reduces blood glucose levels in type 2 diabetes.Mar 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2020 Apr ;19(4):2690-2696. Epub 2020 Feb 4. PMID: 32256750
Article Published Date : Mar 31, 2020
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents
[+]

Icariin treatment rescues diabetes induced bone loss.Dec 15, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2022 Dec 16 ;11(24). Epub 2022 Dec 16. PMID: 36552853
Article Published Date : Dec 15, 2022
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Diabetic Complications, Osteoporosis
Pharmacological Actions : Antioxidants, Osteoprotective
[+]

Long-term icariin treatment ameliorates cognitive deficits.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Interv Aging. 2019 ;14:817-826. Epub 2019 May 7. PMID: 31190768
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Protective effects of icariin on traumatic brain injury. Dec 31, 2020

Pubmed Data : Curr Neurovasc Res. 2021 ;18(5):508-514. PMID: 34951380
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Traumatic Brain Injury
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

The effect of icariin on autoimmune premature ovarian insufficiency via modulation of Nrf2/HO-1/Sirt1 pathway in mice.Mar 24, 2022

Pubmed Data : Reprod Biol. 2022 Mar 25 ;22(2):100638. Epub 2022 Mar 25. PMID: 35344846
Article Published Date : Mar 24, 2022
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Ovarian Failure
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

The inhibitory effect of icariin nanoparticles on angiogenesis in pulmonary fibrosis.Dec 31, 2020

Pubmed Data : J Nanosci Nanotechnol. 2021 11 1 ;21(11):5429-5435. PMID: 33980352
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Fibrotic
[+]

This study may provide new mechanistic insights into the asthma prevention and treatment of icariin.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:1660. Epub 2020 Jan 31. PMID: 32082160
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Verification of pain-related neuromodulation mechanisms of icariin in knee osteoarthritis.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2021 Dec ;144:112259. Epub 2021 Oct 1. PMID: 34607107
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Arthritis, Osteoarthritis: Knee
Pharmacological Actions : Analgesics
[+]

Anti-inflammatory and immunoregulatory effects of icariin and icaritin.Jun 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2022 Jul ;151:113180. Epub 2022 May 27. PMID: 35676785
Article Published Date : Jun 30, 2022
Study Type : Review
Additional Links
Substances : Icariin
Diseases : Asthma, Atherosclerosis, Inflammatory Bowel Diseases, Lupus Nephritis, Multiple Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
[+]

Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.Dec 29, 2022

Pubmed Data : Biofactors. 2022 Dec 30. Epub 2022 Dec 30. PMID: 36585763
Article Published Date : Dec 29, 2022
Study Type : In Vitro Study
Additional Links
Substances : Curcumol, Icariin
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
Additional Keywords : Natural Substance Synergy
[+]

HIF-1 signalling pathway was identified as a potential new pathway for Icariin's treatment against Alzheimer's disease.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:1066819. Epub 2022 Dec 1. PMID: 36532735
Article Published Date : Dec 31, 2021
Study Type : Review
Additional Links
Substances : Icariin
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Icariin accelerates cartilage defect repair by promoting chondrogenic differentiation of BMSCs.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2022 01 ;26(1):202-215. Epub 2021 Dec 3. PMID: 34859578
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective
[+]

Icariin affects cell cycle progression and proliferation of human retinal pigment epithelial cells.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PeerJ. 2020 ;8:e8830. Epub 2020 Mar 20. PMID: 32219038
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Proliferative Vitreoretinopathy (PVR)
Pharmacological Actions : Antiproliferative
[+]

Icariin alleviates IL-1β-induced matrix degradation and eliminates ROS.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2019 ;13:3949-3961. Epub 2019 Nov 21. PMID: 31819369
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Chondroprotective
[+]

Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis.Sep 10, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Orthop Surg Res. 2019 Sep 11 ;14(1):307. Epub 2019 Sep 11. PMID: 31511005
Article Published Date : Sep 10, 2019
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Arthritis, Lipopolysaccharide-Induced Toxicity, Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Osteoprotective
[+]

Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes.Jan 11, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bioengineered. 2021 12 ;12(1):2984-2999. PMID: 34167449
Article Published Date : Jan 11, 2021
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective
[+]

Icariin alleviates osteoarthritis through PI3K/Akt/mTOR/ULK1 signaling pathway.Oct 16, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Med Res. 2022 Oct 17 ;27(1):204. Epub 2022 Oct 17. PMID: 36253872
Article Published Date : Oct 16, 2022
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Autophagy Up-regulation, Interleukin-1 beta downregulation, Matrix metalloproteinase-3 (MMP-3) inhibitor
[+]

Icariin alleviates rheumatoid arthritis via regulating miR-223-3p/NLRP3 signalling axis.Jan 11, 2020

Pubmed Data : Autoimmunity. 2020 12 ;53(8):450-458. Epub 2020 Oct 21. PMID: 33084415
Article Published Date : Jan 11, 2020
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator, NF-kappaB Inhibitor
[+]

Icariin ameliorate Alzheimer's disease by influencing SIRT1 and inhibiting Aβ cascade pathogenesis.Jan 10, 2021

Pubmed Data : J Chem Neuroanat. 2021 11 ;117:102014. Epub 2021 Aug 15. PMID: 34407393
Article Published Date : Jan 10, 2021
Study Type : Review
Additional Links
Substances : Icariin
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents, SIRT1 Activator
[+]

Icariin ameliorates estrogen-deficiency induced bone loss.Jan 31, 2021

Pubmed Data : Phytomedicine. 2021 Feb ;82:153413. Epub 2020 Nov 19. PMID: 33339654
Article Published Date : Jan 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Osteoporosis, Postmenopausal Disorders
Pharmacological Actions : Osteoprotective
[+]

Icariin and its metabolites as potential protective phytochemicals against cardiovascular disease.Feb 28, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2022 Mar ;147:112642. Epub 2022 Jan 21. PMID: 35078094
Article Published Date : Feb 28, 2022
Study Type : Review
Additional Links
Substances : Icariin
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective
[+]

Icariin and its metabolites regulate lipid metabolism: From effects to molecular mechanisms.Oct 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Nov ;131:110675. Epub 2020 Aug 28. PMID: 32861069
Article Published Date : Oct 31, 2020
Study Type : Review
Additional Links
Substances : Flavonoids, Icariin
Diseases : Hyperlipidemia
[+]

Icariin arrests cell cycle progression and induces cell apoptosis through the mitochondrial pathway in human fibroblast-like synoviocytes.Dec 04, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Pharmacol. 2021 Dec 5 ;912:174585. Epub 2021 Oct 19. PMID: 34678240
Article Published Date : Dec 04, 2021
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Icariin as an emerging candidate drug for anticancer treatment: Current status and perspective.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2023 Jan ;157:113991. Epub 2022 Nov 9. PMID: 36370524
Article Published Date : Dec 31, 2022
Study Type : Review
Additional Links
Substances : Icariin
Diseases : Cancers: All
Pharmacological Actions : Apoptotic
[+]

Icariin attenuates amyloid-β (Aβ)-induced neuronal insulin resistance through PTEN downregulation.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:880. Epub 2020 Jun 9. PMID: 32581820
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Icariin attenuates excessive alcohol consumption-induced susceptibility to atrial fibrillation through SIRT3 signaling.Sep 30, 2022

Pubmed Data : Biochim Biophys Acta Mol Basis Dis. 2022 Oct 1 ;1868(10):166483. Epub 2022 Jul 5. PMID: 35798229
Article Published Date : Sep 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Cardiac Arrhythmias
Pharmacological Actions : Cardioprotective
Additional Keywords : Risk Reduction
[+]

Icariin attenuates renal fibrosis in chronic kidney disease.Oct 31, 2021

Pubmed Data : Phytother Res. 2021 Nov ;35(11):6204-6215. Epub 2021 Aug 23. PMID: 34426999
Article Published Date : Oct 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Chronic Kidney Disease (CKD)
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

Icariin attenuates β-amyloid-induced neurotoxicity.Nov 01, 2010

Pubmed Data : Neuropharmacology. 2010 Nov;59(6):542-50. Epub 2010 Aug 12. PMID: 20708632
Article Published Date : Nov 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Alzheimer's Disease, Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
[+]

Icariin attenuation of diabetic kidney disease.Jan 31, 2022

Pubmed Data : J Biomed Nanotechnol. 2022 Feb 1 ;18(2):488-497. PMID: 35484747
Article Published Date : Jan 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Apoptotic, Renoprotective
[+]

Icariin can promote the levels of bone-formation markers, accelerate fracture healing.Dec 31, 2019

Pubmed Data : Curr Pharm Biotechnol. 2020 ;21(15):1645-1653. PMID: 32525771
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Fractures: Bone
[+]

Icariin could attenuate AGE-induced oxidative stress and mitochondrial apoptosis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:7940808. Epub 2019 Apr 22. PMID: 31178973
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Advanced Glycation End products (AGE), Diabetes: Cognitive Dysfunction, Encephalopathy
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
[+]

Icariin could promote gastric cancer cell apoptosis.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:1955101. Epub 2022 Jul 15. PMID: 35873631
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Icariin enhances cell survival in lipopolysaccharide-induced synoviocytes.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2021 Jan ;21(1):72. Epub 2020 Nov 25. PMID: 33365072
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Lipopolysaccharide-Induced Toxicity, Osteoarthritis, Rheumatoid Arthritis
Pharmacological Actions : Antioxidants
[+]

Icariin induces apoptosis of human lung adenocarcinoma cells.Dec 14, 2019

Pubmed Data : Life Sci. 2019 Dec 15 ;239:116879. Epub 2019 Nov 2. PMID: 31682849
Article Published Date : Dec 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Icariin inhibits gastric cancer cell growth.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221097363. PMID: 35532261
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , MicroRNA modulator
[+]

Icariin inhibits oral squamous cell carcinoma cell proliferation and induces apoptosis.Aug 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2021 Sep ;22(3):942. Epub 2021 Jul 1. PMID: 34306206
Article Published Date : Aug 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Icariin inhibits RANKL-induced osteoclastogenesis in RAW264.7 cells.Jan 15, 2022

Pubmed Data : Biochem Biophys Res Commun. 2022 04 16 ;600:6-13. Epub 2022 Feb 9. PMID: 35182975
Article Published Date : Jan 15, 2022
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Osteoporosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor
[+]

Icariin inhibits the growth of human cervical cancer cells.Apr 30, 2019

Pubmed Data : J BUON. 2019 May-Jun;24(3):990-996. PMID: 31424652
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
[+]

Icariin inhibits the inflammation through down-regulating NF-κB/HIF-2α signal pathways in chondrocytes.Jan 26, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Rep. 2020 11 27 ;40(11). PMID: 33155655
Article Published Date : Jan 26, 2020
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
[+]

Icariin may play a protective role in atherosclerosis, and H19 may be a potential therapeutic target.Mar 04, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Ther Nucleic Acids. 2021 Mar 5 ;23:464-475. Epub 2020 Dec 3. PMID: 33510936
Article Published Date : Mar 04, 2021
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Atherosclerosis
Pharmacological Actions : Antioxidants, MicroRNA modulator
[+]

Icariin mitigates the growth and invasion ability of human oral squamous cell carcinoma.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2020 ;13:299-307. Epub 2020 Jan 10. PMID: 32021276
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Oral Cancer
Pharmacological Actions : Antiproliferative
[+]

Icariin prevents oestrogen deficiency-induced alveolar bone loss.Jan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Prolif. 2020 Feb ;53(2):e12743. Epub 2020 Jan 13. PMID: 31943455
Article Published Date : Jan 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
[+]

Icariin promotes osteoblast differentiation and mineralization in vitro.Dec 29, 2010

Pubmed Data : J Cell Biochem. 2010 Dec 29. Epub 2010 Dec 29. PMID: 21192042
Article Published Date : Dec 29, 2010
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Osteoporosis
[+]

Icariin promotes survival, proliferation, and differentiation of neural stem cells.Dec 31, 2020

Pubmed Data : Stem Cells Int. 2021 ;2021:9974625. Epub 2021 Jun 23. PMID: 34257671
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Icariin promotes the repair of PC12 cells by inhibiting endoplasmic reticulum stress.Feb 18, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2021 Feb 19 ;21(1):69. Epub 2021 Feb 19. PMID: 33607999
Article Published Date : Feb 18, 2021
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Icariin protects H9c2 rat cardiomyoblasts from doxorubicin-induced cardiotoxicity.Nov 13, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2021 Nov 14 ;13(11). Epub 2021 Nov 14. PMID: 34836326
Article Published Date : Nov 13, 2021
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress
Pharmacological Actions : Cardioprotective, Chemoprotective Agents
[+]

Icariin protects neurons from endoplasmic reticulum stress-induced apoptosis.Aug 14, 2020

Pubmed Data : Life Sci. 2020 Aug 15 ;255:117847. Epub 2020 May 27. PMID: 32470450
Article Published Date : Aug 14, 2020
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Stroke: Ischemic
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Icariin regulates stem cell migration for endogenous repair of intervertebral disc degeneration.Mar 09, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2022 Mar 10 ;22(1):63. Epub 2022 Mar 10. PMID: 35272637
Article Published Date : Mar 09, 2022
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Chondroprotective
[+]

Icariin represses the inflammatory responses and survival of rheumatoid arthritis fibroblast-like synoviocytes.Jul 01, 2022

Pubmed Data : Int Immunopharmacol. 2022 Jul 2 ;110:108991. Epub 2022 Jul 2. PMID: 35792272
Article Published Date : Jul 01, 2022
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Icariin sensitizes human colon cancer cells to TRAIL‑induced apoptosis via ERK‑mediated upregulation of death receptors.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2020 03 ;56(3):821-834. Epub 2020 Jan 24. PMID: 32124960
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Icariin treatment protects against gentamicin-induced ototoxicity.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:620741. Epub 2021 Feb 18. PMID: 33679402
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions : Chemoprotective Agents
[+]

Icariin, a natural flavonol glycoside, induces apoptosis in human hepatoma cells.Dec 08, 2010

Pubmed Data : Cancer Lett. 2010 Dec 8 ;298(2):222-30. Epub 2010 Jul 31. PMID: 20674153
Article Published Date : Dec 08, 2010
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic
[+]

Icariin-induced inhibition of SIRT6/NF-κB triggers redox mediated apoptosis and enhances anti-tumor immunity.Oct 31, 2020

Pubmed Data : Cancer Sci. 2020 Nov ;111(11):4242-4256. Epub 2020 Oct 7. PMID: 32926492
Article Published Date : Oct 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Immunomodulatory, NF-kappaB Inhibitor
[+]

Icariin: a potential molecule for treatment of knee osteoarthritis. Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:811808. Epub 2022 Apr 5. PMID: 35479319
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-9 (MMP-9) inhibitor, Osteoprotective , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Icariin: A potential neuroprotective agent in Alzheimer's disease and Parkinson's disease.Jul 07, 2022

Pubmed Data : Neurochem Res. 2022 Jul 8. Epub 2022 Jul 8. PMID: 35802286
Article Published Date : Jul 07, 2022
Study Type : Review
Additional Links
Substances : Icariin
Diseases : Alzheimer's Disease, Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Icarinn may have a neuroprotective effect for ischemia-related brain injury.May 01, 2009

Pubmed Data : Eur J Pharmacol. 2009 May 1;609(1-3):40-4. Epub 2009 Mar 20. PMID: 19303870
Article Published Date : May 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Brain Ischemia, Stroke
Pharmacological Actions : Neuroprotective Agents
[+]

Immunomodulatory effects of icariin in a myocardial infarction mouse model.Apr 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bioengineered. 2022 May ;13(5):12504-12515. PMID: 35579292
Article Published Date : Apr 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Myocardial Infarction
Pharmacological Actions : Anti-Apoptotic, Cardioprotective, Immunomodulatory
[+]

Impact of Icariin and its derivatives on inflammatory diseases and relevant signaling pathways.May 17, 2022

Pubmed Data : Int Immunopharmacol. 2022 May 18 ;108:108861. Epub 2022 May 18. PMID: 35597118
Article Published Date : May 17, 2022
Study Type : Review
Additional Links
Substances : Icariin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Influence of icariin on inflammation, apoptosis, invasion, and tumor immunity in cervical cancer.Apr 12, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2021 Apr 13 ;21(1):206. Epub 2021 Apr 13. PMID: 33849528
Article Published Date : Apr 12, 2021
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Cervical Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Long term therapeutic effects of icariin-loaded PLGA microspheres in an experimental model of optic nerve ischemia.Apr 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bioeng Transl Med. 2022 May ;7(2):e10289. Epub 2022 Jan 7. PMID: 35600664
Article Published Date : Apr 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Ischemia, Ischemic Optic Neuropathy
Pharmacological Actions : Neuroprotective Agents
[+]

Optimized icariin phytosomes exhibit enhanced cytotoxicity and apoptosis-inducing activities in ovarian cancer cells.Apr 10, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceutics. 2020 Apr 11 ;12(4). Epub 2020 Apr 11. PMID: 32290412
Article Published Date : Apr 10, 2020
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Ovarian Cancer
Pharmacological Actions : Apoptotic
[+]

Osteoprotective effects of flavonoids: Evidence from in vivo and in vitro studies.May 31, 2022

Pubmed Data : Mol Med Rep. 2022 Jun ;25(6). Epub 2022 Apr 27. PMID: 35475514
Article Published Date : May 31, 2022
Study Type : Review
Additional Links
Substances : Chrysin, Citrus naringin, Flavonoids, Icariin, Quercetin
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
[+]

Potential effects of icariin, the Epimedium-derived bioactive compound in the treatment of COVID-19: a hypothesis.Aug 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2022 Sep ;395(9):1019-1027. Epub 2022 Jun 3. PMID: 35657423
Article Published Date : Aug 31, 2022
Study Type : Review
Additional Links
Substances : Icariin
Diseases : Coronavirus Infection
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiviral Agents
[+]

Proapoptotic effect of icariin on human ovarian cancer cells.Dec 31, 2021

Pubmed Data : Am J Chin Med. 2022 ;50(2):589-619. Epub 2022 Feb 3. PMID: 35114909
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Ovarian Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, NF-kappaB Inhibitor
[+]

Research progress on icariin, a traditional Chinese medicine extract, in the treatment of asthma.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Allergol Immunopathol (Madr). 2022 ;50(1):9-16. Epub 2022 Jan 1. PMID: 34873891
Article Published Date : Dec 31, 2021
Study Type : Review
Additional Links
Substances : Flavonoids, Icariin
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Plant Extracts
[+]

The anti-inflammatory effect of icariin may provide a potential therapeutic strategy for the treatment of brain injury after stroke.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2021 Dec ;59(1):1473-1479. PMID: 34711127
Article Published Date : Nov 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Icariin
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The neuroprotective effects of icariin on ageing, various neurological, neuropsychiatric disorders, and brain injury induced by radiation exposure.Jan 13, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging (Albany NY). 2022 02 14 ;14(3):1562-1588. Epub 2022 Feb 14. PMID: 35165207
Article Published Date : Jan 13, 2022
Study Type : Review
Additional Links
Substances : Flavonoids, Icariin
Diseases : Aging: Brain , Alzheimer's Disease, Cerebral Ischemia, Depression, Multiple Sclerosis, Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Therapeutic effects of icariin and icariside II on diabetes mellitus and its complications.Jan 01, 2023

Pubmed Data : Crit Rev Food Sci Nutr. 2023 Jan 2:1-26. Epub 2023 Jan 2. PMID: 36591787
Article Published Date : Jan 01, 2023
Study Type : Review
Additional Links
Substances : Icariin
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Cardioprotective, Pancreato Protective Agents

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