Icariin

Name	AC	CK
Osteoporosis	10	23
Alzheimer's Disease	14	21
Diabetes Mellitus: Type 2	5	17
Neurodegenerative Diseases	6	10
Oxidative Stress	5	9
Inflammation	5	8
Memory Disorders	4	8
Multiple Sclerosis	5	8
Asthma	5	7
Diabetic Nephropathy	4	7
Lipopolysaccharide-Induced Toxicity	5	7
Osteoarthritis	7	7
Aging	3	6
Brain Inflammation	3	6
Cardiomyopathy	3	6
Diabetic Complications	3	6
Erectile Dysfunction	3	6
Hypertension	3	6
Lung Cancer	3	6
Nonalcoholic fatty liver disease (NAFLD)	3	6
Rheumatoid Arthritis	5	6
Cancer Metastasis	2	5
Depression	3	5
Diabetes Mellitus: Type 1	2	5
Prostate Cancer	3	5
Cognitive Decline/Dysfunction	2	4
Epilepsy	2	4
Fractures: Bone	3	4
High Fat Diet	2	4
Learning disorders	2	4
Ovarian Cancer	3	4
Parkinson's Disease	3	4
Polycystic Ovary Syndrome	2	4
Aging: Brain	2	3
Arthritis	2	3
Atherosclerosis	3	3
Brain Ischemia	2	3
Chemotherapy-Induced Toxicity: Cisplatin	1	3
Chronic Kidney Disease (CKD)	2	3
Degenerative Disk Disease	2	3
Endothelial Dysfunction	1	3
Kidney Fibrosis	1	3
Myocardial Infarction	2	3
Osteoarthritis: Knee	2	3
Schizophrenia	2	3
Stroke	2	3
Stroke: Ischemic	2	3
Uveitis	1	3
Aluminum Toxicity	1	2
Atopic Dermatitis	1	2
Autism Spectrum Disorders	1	2
Bisphenol Toxicity	1	2
Bone Diseases	1	2
Brain: Oxidative Stress	1	2
Breast Cancer: Triple Negative	2	2
Cerebral Ischemia	2	2
Cervical Cancer	2	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Colitis	1	2
Cystitis	1	2
Endometritis	1	2
Escherichia coli Infections	1	2
Fibrosis	1	2
Gastric Cancer	2	2
Heart Failure	1	2
High Fructose Diet	1	2
Hyperalgesia	1	2
Infertility: Male	1	2
Insulin Resistance	1	2
Kidney Damage	1	2
Kidney Failure: Chronic	1	2
Low Back Pain	1	2
Lung Injury: Acute	1	2
Mercury Poisoning	1	2
Metabolic Diseases	1	2
Metabolic Syndrome X	1	2
Myocardial Fibrosis	1	2
Obesity	1	2
Oral Cancer	2	2
Osteoporosis: Age-Related	1	2
Ovarian Failure	1	2
Postoperative Recovery	1	2
Prostatic Hyperplasia: Benign	1	2
Pulmonary Fibrosis	1	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Radiation	1	2
Sarcopenia	1	2
Seizures	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Traumatic Brain Injury	1	2
Ulcerative Colitis	1	2
Wound Healing: Delayed	1	2
Advanced Glycation End products (AGE)	1	1
Breast Cancer	1	1
Cancers: All	1	1
Cardiac Arrhythmias	1	1
Cardiovascular Diseases	1	1
Chemotherapy-Induced Toxicity: Doxorubicin	1	1
Chemotherapy-Induced Toxicity: Gentamicin	1	1
Colon Cancer	1	1
Coronavirus Infection	1	1
Diabetes: Cognitive Dysfunction	1	1
Encephalopathy	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Hyperlipidemia	1	1
Inflammatory Bowel Diseases	1	1
Ischemia	1	1
Ischemic Optic Neuropathy	1	1
Liver Cancer	1	1
Lupus Nephritis	1	1
Postmenopausal Disorders	1	1
Proliferative Vitreoretinopathy (PVR)	1	1
Spinal Cord Injuries	1	1
Squamous cell carcinoma	1	1
Vascular Calcification	1	1

Name	AC	CK
Anti-Inflammatory Agents	46	75
Neuroprotective Agents	37	61
Antioxidants	24	41
Osteoprotective	12	27
Interleukin-6 Downregulation	14	25
Anti-Apoptotic	15	23
Tumor Necrosis Factor (TNF) Alpha Inhibitor	12	21
Apoptotic	16	18
Cardioprotective	11	18
NF-kappaB Inhibitor	12	18
Antiproliferative	14	17
Nrf2 activation	8	15
Renoprotective	7	14
Interleukin-1 beta downregulation	9	13
MicroRNA modulator	7	12
Anti-Fibrotic	5	11
Heme oxygenase-1 up-regulation	6	11
Chemoprotective Agents	5	9
Anti-metastatic	4	7
Autophagy Up-regulation	5	7
Chondroprotective	5	6
Gastrointestinal Agents	3	6
Immunomodulatory	4	5
Analgesics	2	4
Hepatoprotective	2	4
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	4
Transforming growth factor beta (TGF-β) inhibitor	2	4
Hypolipidemic	2	3
Angiogenesis Inhibitors	1	2
Anti-Cachexic Agents	1	2
Anticonvulsants	1	2
Antidepressive Agents	1	2
Antihypertensive Agents	1	2
Antioxidant	1	2
Brain-derived neurotrophic factor modulator	1	2
Cell cycle arrest	2	2
Fertility Agents: Male	1	2
Gastroprotective	1	2
Hypoglycemic Agents	1	2
Interleukin-10 downregulation	1	2
Interleukin-10 upregulation	1	2
Interleukin-12 downregulation	1	2
Malondialdehyde Down-regulation	1	2
Neuroplasticity enhancement	1	2
Radioprotective	1	2
Superoxide Dismutase Up-regulation	1	2
Antiviral Agents	1	1
Chemosensitizer	1	1
Interleukin-8 downregulation	1	1
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	1
Pancreato Protective Agents	1	1
SIRT1 Activator	1	1
Tumor Suppressor Protein p53 Upregulation	1	1
Vasoprotective	1	1

[+]

Icariin promoted the proliferation and osteogenic differentiation of impaired BMSCs by upregulating GLI-1. Jul 14, 2023

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Pubmed Data : J Orthop Surg Res. 2023 Jul 15 ;18(1):500. Epub 2023 Jul 15. PMID: 37454090

Article Published Date : Jul 14, 2023

Study Type : Human Study

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Substances : Icariin

Diseases : Diabetes Mellitus: Type 2, Osteoporosis

Pharmacological Actions : Osteoprotective

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Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization.Mar 17, 2022

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Pubmed Data : Iran J Basic Med Sci. 2023 ;26(5):517-525. PMID: 37051097

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Icariin improves brain function decline in aging rats.Nov 30, 2021

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Pubmed Data : Pharm Biol. 2021 Dec ;59(1):183-191. PMID: 33556283

Article Published Date : Nov 30, 2021

Study Type : Animal Study

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Substances : Flavonoids, Icariin

Diseases : Aging

Pharmacological Actions : Neuroprotective Agents

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Icariin improves cardiac function and remodeling via the TGF-β1/Smad signaling pathway in rats following myocardial infarction.Dec 18, 2023

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Icariin inhibits intestinal inflammation of DSS-induced colitis.Dec 31, 2020

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Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2023 Jul 31 ;69(7):196-204. Epub 2023 Jul 31. PMID: 37715385

Article Published Date : Jul 30, 2023

Study Type : Animal Study

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Substances : Icariin

Diseases : Depression

Pharmacological Actions : Anti-Apoptotic, Antidepressive Agents

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Icariin prevents methylmercury-induced experimental neurotoxicity.Jan 14, 2024

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Pubmed Data : Heliyon. 2024 Jan 15 ;10(1):e24050. Epub 2024 Jan 6. PMID: 38226245

Article Published Date : Jan 14, 2024

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Pubmed Data : Front Pharmacol. 2022 ;13:937502. Epub 2022 Sep 13. PMID: 36176424

Article Published Date : Dec 31, 2021

Study Type : Animal Study

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Substances : Icariin

Diseases : Degenerative Disk Disease

Pharmacological Actions : Antioxidants, Chondroprotective, Heme oxygenase-1 up-regulation, Nrf2 activation

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Icariin reduces cognitive dysfunction induced by surgical trauma.Dec 31, 2022

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Pubmed Data : Front Behav Neurosci. 2023 ;17:1162009. Epub 2023 Jun 7. PMID: 37351155

Article Published Date : Dec 31, 2022

Study Type : Animal Study

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Substances : Icariin

Diseases : Brain Inflammation , Cognitive Decline/Dysfunction, Postoperative Recovery

Pharmacological Actions : Neuroprotective Agents

[+]

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Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:1330928. Epub 2022 Nov 15. PMID: 36425058

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Pubmed Data : Phytother Res. 2021 Nov ;35(11):6204-6215. Epub 2021 Aug 23. PMID: 34426999

Article Published Date : Oct 31, 2021

Study Type : In Vitro Study

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Substances : Icariin

Diseases : Chronic Kidney Disease (CKD)

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation

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Icariin attenuates the calcification of vascular smooth muscle cells.Nov 30, 2023

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Pubmed Data : Aging Med (Milton). 2023 Dec ;6(4):379-385. Epub 2023 Oct 10. PMID: 38239714

Article Published Date : Nov 30, 2023

Study Type : In Vitro Study

Additional Links

Substances : Icariin

Diseases : Vascular Calcification

Pharmacological Actions : Vasoprotective

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Icariin enhances cell survival in lipopolysaccharide-induced synoviocytes.Dec 31, 2020

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Pubmed Data : Exp Ther Med. 2021 Jan ;21(1):72. Epub 2020 Nov 25. PMID: 33365072

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

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Substances : Icariin

Diseases : Lipopolysaccharide-Induced Toxicity, Osteoarthritis, Rheumatoid Arthritis

Pharmacological Actions : Antioxidants

[+]

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Pubmed Data : Biochem Biophys Res Commun. 2022 04 16 ;600:6-13. Epub 2022 Feb 9. PMID: 35182975

Article Published Date : Jan 15, 2022

Study Type : In Vitro Study

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Substances : Icariin

Diseases : Osteoporosis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor

[+]

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Pubmed Data : J Cell Biochem. 2010 Dec 29. Epub 2010 Dec 29. PMID: 21192042

Article Published Date : Dec 29, 2010

Study Type : In Vitro Study

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Substances : Icariin

Diseases : Osteoporosis

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Icariin promotes survival, proliferation, and differentiation of neural stem cells.Dec 31, 2020

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Pubmed Data : Stem Cells Int. 2021 ;2021:9974625. Epub 2021 Jun 23. PMID: 34257671

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

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Substances : Icariin

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Icariin promotes the repair of PC12 cells by inhibiting endoplasmic reticulum stress.Feb 18, 2021

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Pubmed Data : BMC Complement Med Ther. 2021 Feb 19 ;21(1):69. Epub 2021 Feb 19. PMID: 33607999

Article Published Date : Feb 18, 2021

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids, Icariin

Diseases : Spinal Cord Injuries

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

Additional Keywords : Plant Extracts

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Icariin protects H9c2 rat cardiomyoblasts from doxorubicin-induced cardiotoxicity.Nov 13, 2021

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Pubmed Data : BMC Complement Med Ther. 2022 Mar 10 ;22(1):63. Epub 2022 Mar 10. PMID: 35272637

Article Published Date : Mar 09, 2022

Study Type : In Vitro Study

Additional Links

Substances : Icariin

Diseases : Degenerative Disk Disease

Pharmacological Actions : Chondroprotective

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Icariin represses the inflammatory responses and survival of rheumatoid arthritis fibroblast-like synoviocytes.Jul 01, 2022

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Pubmed Data : Int Immunopharmacol. 2022 Jul 2 ;110:108991. Epub 2022 Jul 2. PMID: 35792272

Article Published Date : Jul 01, 2022

Study Type : In Vitro Study

Additional Links

Substances : Icariin

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents

[+]

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Pubmed Data : Mol Med Rep. 2022 Jun ;25(6). Epub 2022 Apr 27. PMID: 35475514

Article Published Date : May 31, 2022

Study Type : Review

Additional Links

Substances : Chrysin, Citrus naringin, Flavonoids, Icariin, Quercetin

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

[+]

Therapeutic effects of icariin and icariside II on diabetes mellitus and its complications.Jan 01, 2023

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Pubmed Data : Crit Rev Food Sci Nutr. 2023 Jan 2:1-26. Epub 2023 Jan 2. PMID: 36591787

Article Published Date : Jan 01, 2023

Study Type : Review

Additional Links

Substances : Icariin

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Cardioprotective, Pancreato Protective Agents

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View the Evidence: 157 Abstracts with Icariin Research

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Icariin promoted the proliferation and osteogenic differentiation of impaired BMSCs by upregulating GLI-1. Jul 14, 2023

Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization.Mar 17, 2022

Icariin ameliorates endothelial dysfunction in type 1 diabetes.Dec 31, 2020

Icariin attenuates renal fibrosis in vivo and in vitro by inhibiting the Notch2/Hes-1 pathway.Apr 14, 2022

Icariin exhibits protective effects on cisplatin-induced cardiotoxicity.Aug 31, 2022

Icariin inhibits prostate cancer bone metastasis and destruction.Oct 31, 2023

Icariin inhibits the malignant progression of lung cancer.May 31, 2022

Multifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer's disease.Nov 30, 2022

A phytomolecule icariin protects from sarcopenia.Nov 30, 2022

Anti-inflammatory effects of icariin in the acute and chronic phases of the mouse pilocarpine model of epilepsy.Dec 04, 2023

Cardioprotective effect of icariin against myocardial fibrosis and its molecular mechanism in diabetic cardiomyopathy.Sep 30, 2021

Effect of icariin in a rat model of colchicine-induced cognitive deficit: role of β - amyloid proteolytic enzymes.Nov 06, 2022

Effects of icariin on alleviating schizophrenia-like symptoms.Nov 19, 2022

Effects of icariin on modulating gut microbiota and regulating metabolite alterations to prevent bone loss in ovariectomized rat model.Dec 31, 2021

Exploration of the effect of icariin on nude mice with lung cancer bone metastasis.Dec 31, 2021

Icariin alleviates autistic-like behavior, hippocampal inflammation and vGlut1 expression in adult BTBR mice.May 07, 2023

Icariin alleviates Escherichia coli lipopolysaccharide-mediated endometritis.Sep 05, 2022

Icariin alleviates glucocorticoid-induced osteoporosis.Dec 31, 2019

Icariin alleviates high-fat diet-induced nonalcoholic fatty liver disease.Dec 31, 2023

Icariin alleviates nonalcoholic fatty liver disease in polycystic ovary syndrome.Jan 04, 2023

Icariin ameliorated chronic kidney disease.Aug 09, 2023

Icariin ameliorates Alzheimer's disease pathology.Mar 31, 2022

Icariin ameliorates behavioral deficits and neuropathology in a mouse model of multiple sclerosis.Mar 31, 2023

Icariin ameliorates diabetic cardiomyopathy.Dec 31, 2019

Icariin ameliorates diabetic renal tubulointerstitial fibrosis.Dec 31, 2020

Icariin ameliorates learning and memory impairments.Aug 31, 2019

Icariin ameliorates lower back pain.Dec 31, 2019

Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters.Dec 31, 2022

Icariin ameliorates metabolic syndrome-induced benign prostatic hyperplasia in rats.Feb 28, 2022

Icariin ameliorates osteoporosis by activating autophagy in ovariectomized rats.Jan 17, 2024

Icariin ameliorates oxidative stress-induced inflammation, apoptosis, and heart failure.Dec 31, 2022

Icariin ameliorates spermatogenesis disorder in obesity.Jun 30, 2023

Icariin ameliorates streptozocin-induced diabetic nephropathy through suppressing the TLR4/NF-κB signal pathway.Feb 14, 2021

Icariin ameliorates the cognitive function in an epilepsy neonatal rat model.Dec 31, 2019

Icariin ameliorates the cuprizone-induced demyelination associated with antioxidation and anti-inflammation.Jan 31, 2024

Icariin ameliorates the progression of experimental autoimmune encephalomyelitis.Oct 14, 2020

Icariin and competing endogenous RNA network: A potential protective strategy against contrast-induced acute kidney injury.Dec 31, 2021

Icariin attenuates bleomycin-induced pulmonary fibrosis by targeting Hippo/YAP pathway.Oct 31, 2021

Icariin attenuates cyclophosphamide-induced cystitis.Apr 30, 2022

Icariin attenuates dopaminergic neural loss in haloperidol-induced Parkinsonism.Dec 29, 2023

Icariin attenuates ischemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signaling pathway in rats.Apr 21, 2022

Icariin attenuates monocrotaline-induced pulmonary arterial hypertension.Dec 31, 2019

Icariin attenuates perfluorooctane sulfonate-induced testicular toxicity.Mar 20, 2022

Icariin attenuates the tumor growth by targeting miR-1-3p/TNKS2/Wnt/β-catenin signaling axis in ovarian cancer.Dec 31, 2021

Icariin attenuates thioacetamide‑induced bone loss via the RANKL‑p38/ERK‑NFAT signaling pathway.Mar 31, 2022

Icariin decreases cell proliferation and inflammation of rheumatoid arthritis-fibroblast like synoviocytes.Jan 31, 2024

Icariin enhances AMP-activated protein kinase and prevents high fructose and high salt-induced metabolic syndrome.Oct 31, 2020

Icariin enhances youth-like features by attenuating the declined gut microbiota in the aged mice.Dec 31, 2020

Icariin has a neuroprotective effect on memory impairment and neurochemical deficits in age-acceleration prone mice.Jun 02, 2010

Icariin has a synergistic effect on the osteoinductivity of bone morphogenetic protein 2 at ectopic sites.Jan 09, 2023

Icariin improves brain function decline in aging rats.Nov 30, 2021

Icariin improves cardiac function and remodeling via the TGF-β1/Smad signaling pathway in rats following myocardial infarction.Dec 18, 2023

Icariin improves cognitive deficits by reducing the deposition of β-amyloid peptide and inhibition of neurons apoptosis.Jan 06, 2020

Icariin improves cutaneous wound healing in streptozotocin-induced diabetes.Jan 31, 2022

Icariin improves erectile function in spontaneously hypertensive rats by up-regulating Nrf2.Jan 31, 2021

Icariin improves glucocorticoid resistance in a murine model of asthma with depression.Aug 21, 2022

Icariin improves learning and memory function in Aβ1-42-induced AD mice.Jan 09, 2024

Icariin improves renal interstitial fibrosis in a rat model of chronic renal failure.Mar 31, 2022

Icariin improves the cognitive function of APP/PS1 mice via suppressing endoplasmic reticulum stress.Sep 30, 2019

Icariin inhibits intestinal inflammation of DSS-induced colitis.Dec 31, 2020

Icariin inhibits the formation of mitochondria-associated membranes (MAMs) and improves erectile function in rats treated with prostate radiation.Aug 31, 2022

Icariin may accelerate fracture healing by activating the BMP-2/Smad5/Runx2 pathway.Nov 30, 2021

Icariin may exert as a protector in type 2 diabetes mellitus-induced diabetic cardiomyopathy.Dec 31, 2019

Icariin modulates eNOS activity via effect on post-translational protein-protein interactions to improve erectile functio.Dec 31, 2020

Icariin prevents depression-like behaviors in chronic unpredictable mild stress.Jul 30, 2023

Icariin prevents methylmercury-induced experimental neurotoxicity.Jan 14, 2024

Icariin protects against against learning and memory deficits induced by aluminium in rats.Aug 01, 2007

Icariin protects against brain injury in an experimental model of stroke.Jul 01, 2010

Icariin protects podocytes from NLRP3 activation by Sesn2-induced mitophagy through the Keap1-Nrf2/HO-1 axis in diabetic nephropathy.Feb 26, 2022

Icariin protects rotenone-induced neurotoxicity through induction of SIRT3.Jan 14, 2019

Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration.Dec 31, 2021

Icariin reduces cognitive dysfunction induced by surgical trauma.Dec 31, 2022

Icariin

View the Evidence:
157 Abstracts with Icariin Research