Indole-3-Carbinol

Name	AC	CK
Systemic Lupus Erythematosus	3	22
Breast Cancer	14	18
Prostate Cancer	13	15
Lung Cancer	6	11
Lupus Erythematosus: Systemic	1	10
Wound Healing	1	10
Inflammation	5	9
Melanoma	7	8
Cancers: All	7	7
Nasopharyngeal Cancer	4	7
Cervical Cancer	4	6
Oxidative Stress	4	6
Chemotherapy-Induced Toxicity: Doxorubicin	3	5
Liver Fibrosis	3	5
Obesity	3	5
Pancreatic Cancer	4	5
Cancers: Drug Resistant	2	4
Cervical Dysplasia	2	4
Liver Cancer	3	4
Acute Myeloid Leukemia	2	3
Liver Damage	2	3
Alcohol Toxicity	1	2
Atherosclerosis	1	2
Autoimmune Diseases	1	2
Bisphenol Toxicity	1	2
Brain Inflammation	1	2
Breast Cancer: BRCA1	2	2
Breast Cancer: Bone Metastasis	1	2
Breast Cancer: Triple Negative	1	2
Cancers: Multi-Drug Resistant	1	2
Cerebral Stroke	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Citrobacter Infection	1	2
Clostridium Infections	1	2
Colitis	1	2
Diabetes Mellitus: Type 2	1	2
Diabetes: Oxidative Stress	1	2
Drug Toxicity: Methotrexate	1	2
Dysbiosis	1	2
Food Allergies	1	2
High Fat Diet	1	2
Hyperglycemia	1	2
Hyperlipidemia	1	2
Ischemia	1	2
Laryngeal Cancer	1	2
Leukemia	1	2
Lipopolysaccharide-Induced Toxicity	1	2
Liver Steatosis	1	2
Lung Cancer: Prevention	1	2
Metabolic Diseases	1	2
Pain	1	2
Papillomavirus Infections	1	2
Parkinson's Disease	1	2
Polycystic Ovary Syndrome	1	2
Prenatal Chemical Exposures	1	2
Prostate Cancer: Prevention	2	2
Rheumatoid Arthritis	1	2
Skin Cancer	2	2
Staphylococcal Infections	1	2
Acute lymphoblastic leukemia (ALL)	1	1
Benzo[a]pyrene-induced Toxicity	1	1
Burkitt Lymphoma	1	1
Cancer Metastasis	1	1
Cancers	1	1
Candida Albicans	1	1
Candida Infection	1	1
Cardiovascular Diseases	1	1
Chronic Lymphocytic Leukemia	1	1
Colorectal Cancer	1	1
Endometrial Cancer	1	1
Estrogen Dominance	1	1
Glioma	1	1
Gram-Positive Bacterial Infections	1	1
High-Grade Prostatic Intraepithelial Neoplastic Lesions	1	1
Human Papillomavirus (HPV)	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Liver Disease	1	1
Neurodegenerative Diseases	1	1
Osteoporosis	1	1
Osteosarcoma	1	1
Ovarian Cancer	1	1

Name	AC	CK
Apoptotic	40	55
Antiproliferative	35	48
Anti-Inflammatory Agents	15	28
Anticarcinogenic Agents	20	28
Chemopreventive	17	23
Antioxidants	11	18
Cell cycle arrest	12	16
Interleukin-6 Downregulation	7	14
Tumor Necrosis Factor (TNF) Alpha Inhibitor	7	14
Antineoplastic Agents	9	10
Chemosensitizer	6	9
Hepatoprotective	5	9
Chemoprotective Agents	5	8
MicroRNA modulator	5	8
NF-kappaB Inhibitor	5	8
Nrf2 activation	5	8
Cardioprotective	4	6
Chemotherapeutic	4	6
Cyclooxygenase 2 Inhibitors	3	6
Anti-Apoptotic	4	5
Neuroprotective Agents	3	5
Angiogenesis Inhibitors	3	4
Heme oxygenase-1 up-regulation	2	4
Immunomodulatory	2	4
Anti-Fibrotic	2	3
Bcl-2 protein down-regulation	2	3
Tumor Suppressor Protein p53 Upregulation	3	3
Anti-Allergic Agents	1	2
Antifungal Agents	2	2
Antinoceceptive	1	2
Catalase Up-Regulation	1	2
Cytoprotective	1	2
Gastrointestinal Agents	1	2
Hypolipidemic	1	2
Immunomodulatory: Th17 downregulation	1	2
Interleukin-1 beta downregulation	1	2
Interleukin-10 downregulation	1	2
Superoxide Dismutase Up-regulation	1	2
Telomerase Inhibitor	2	2
Anti-Estrogenic	1	1
Anti-metastatic	1	1
Antiviral Agents	1	1
Autophagy Up-regulation	1	1
Estrogen Receptor Modulators	1	1
Histone deacetylase inhibitor	1	1
Multidrug Resistance Gene Modulators	1	1
P21 Activation	1	1
Proteasome Inhibitors	1	1
Wnt/β-catenin signaling pathway modulation	1	1

Attenuation of hyperglycemia-mediated oxidative stress by indole-3-carbinol and its metabolite 3, 3'- diindolylmethane.May 31, 2014

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Pubmed Data : J Physiol Biochem. 2014 Jun ;70(2):525-34. Epub 2014 Apr 9. PMID: 24715233

Article Published Date : May 31, 2014

Study Type : Animal Study

Additional Links

Substances : Indole-3-Carbinol

Diseases : Diabetes: Oxidative Stress, Diabetes Mellitus: Type 2, Hyperglycemia

Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Superoxide Dismutase Up-regulation

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Both indole-3-carbinol and myo-inositol inhibit the development of vinyl carbamate induced pulmonary adenocarcinoma in mice.Jan 31, 2010

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Indole-3-carbinol ameliorated the isoproterenol-induced myocardial infarction.Feb 16, 2022

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Pubmed Data : Nat Prod Res. 2022 Feb 17:1-6. Epub 2022 Feb 17. PMID: 35175868

Article Published Date : Feb 16, 2022

Study Type : Animal Study

Additional Links

Substances : Indole-3-Carbinol

Diseases : Myocardial Infarction

Pharmacological Actions : Anti-Apoptotic, Cardioprotective

Problem Substances : Isoproterenol

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Indole-3-carbinol ameliorated the thioacetamide-induced hepatic encephalopathy.Jun 14, 2023

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Pubmed Data : Toxicology. 2023 Jun 15 ;492:153542. Epub 2023 May 5. PMID: 37150287

Article Published Date : Jun 14, 2023

Study Type : Animal Study

Additional Links

Substances : Indole-3-Carbinol

Diseases : Chemically-Induced Liver Damage, Encephalopathy, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Neuroprotective Agents

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Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Lett. 2011 Dec 1 ;311(1):57-65. Epub 2011 Jul 2. PMID: 21767909

Article Published Date : Nov 30, 2011

Study Type : Animal Study

Additional Links

Substances : Indole-3-Carbinol

Diseases : Lung Cancer

Pharmacological Actions : Anticarcinogenic Agents

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Indole-3-carbinol inhibits cell proliferation and induces apoptosis in Hep-2 laryngeal cancer cells.Jun 30, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Ann Surg. 2016 Jun 8. Epub 2016 Jun 8. PMID: 27280500

Article Published Date : Jun 07, 2016

Study Type : Animal Study

Additional Links

Substances : Indole-3-Carbinol

Diseases : Clostridium Infections

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nature. 2022 Jul ;607(7919):585-592. Epub 2022 Jun 22. PMID: 35732737

Pubmed Data : Carcinogenesis. 2015 Jun ;36(6):666-75. Epub 2015 Apr 20. PMID: 25896445

Article Published Date : May 31, 2015

Study Type : Animal Study

Additional Links

Substances : Indole-3-Carbinol, Silibinin

Diseases : Inflammation, Lung Cancer: Prevention

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antiproliferative

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These results unraveled complex relationships among indole-3-carbinol ingestion, gut microbiota, and prostate tumor development.Feb 21, 2019

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Pubmed Data : J Biomed Res. 2014 Sep ;28(5):339-48. Epub 2014 Apr 20. PMID: 25332705

Article Published Date : Aug 31, 2014

Study Type : Review

Additional Links

Substances : Cruciferous Vegetables, Indole-3-Carbinol

Diseases : High-Grade Prostatic Intraepithelial Neoplastic Lesions, Prostate Cancer, Prostate Cancer: Prevention

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Estrogenic, Anti-Inflammatory Agents, Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemopreventive

Additional Keywords : Risk Reduction

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3,3'-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment.Aug 25, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Published Date : Apr 30, 2015

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Indole-3-carbinol and 3,3'-diindolylmethane could inhibit cancer development and progression by regulating multiple cellular signalling pathways.Jul 09, 2013

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Pubmed Data : Chem Biol Drug Des. 2023 Jun ;101(6):1367-1381. Epub 2023 Mar 5. PMID: 36798994

Article Published Date : May 31, 2023

Study Type : In Vitro Study

Additional Links

Substances : Indole-3-Carbinol

Diseases : Gastric Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic

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Indole-3-carbinol induces apoptosis in human osteosarcoma MG-63 and U2OS cells.Dec 31, 2017

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Pubmed Data : Mol Nutr Food Res. 2016 06 ;60(6):1228-38. Epub 2016 May 23. PMID: 26840393

Article Published Date : Dec 31, 2015

Study Type : Review

Additional Links

Substances : Indole-3-Carbinol

Diseases : Benzo[a]pyrene-induced Toxicity , Cancers: All

Pharmacological Actions : Chemopreventive

Additional Keywords : Epigenetic Modification

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Some degree of the cytotoxic and proapoptotic effects of indole-3-carbinol on colon cancer cells is dependent on activation of the aryl hydrocarbon receptor.Dec 31, 2015

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Pubmed Data : J Korean Med Sci. 2013 Apr ;28(4):527-33. Epub 2013 Mar 27. PMID: 23580227

Article Published Date : Mar 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Genistein, Indole-3-Carbinol

Diseases : Endometrial Cancer

Pharmacological Actions : Anticarcinogenic Agents, Apoptotic

Additional Keywords : Natural Substance Synergy

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The vegetable compound indole-3-carbinol as a dietary supplement may benefit cancer prevention and improve adenovirus oncolytic therapies.Aug 31, 2014

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Pubmed Data : Biosci Biotechnol Biochem. 2008 Aug;72(8):2243-6. Epub 2008 Aug 7. PMID: 18685185

Article Published Date : Aug 01, 2008

Additional Links

Substances : Indole-3-Carbinol

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View the Evidence: 128 Abstracts with Indole-3-Carbinol Research

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Indole-3 carbinol may be beneficial in the treatment of systemic lupus erythematosus. Jan 01, 2001

Indole-3-carbinol could modulate the gene expression involved in wound healing in systemic lupus erythematosus cases and healthy controls.Jun 30, 2020

Indole-3-carbinol in vitro antiviral activity against SARS-Cov-2 virus and in vivo toxicity.Dec 14, 2022

Anti-cancer and cardioprotective effects of indol-3-carbinol in doxorubicin-treated mice.Dec 31, 2015

Anti-inflammatory, antioxidant, antihypertensive, and antiarrhythmic effect of indole-3-carbinol.Jan 31, 2022

Anticancer effects of combination of indole-3-carbinol and hydroxychloroquine on ehrlich ascites carcinoma.Aug 10, 2021

Antiobesity activities of indole-3-carbinol in high-fat-diet-induced obese mice.Mar 31, 2011

Attenuation of hyperglycemia-mediated oxidative stress by indole-3-carbinol and its metabolite 3, 3'- diindolylmethane.May 31, 2014

Both indole-3-carbinol and myo-inositol inhibit the development of vinyl carbamate induced pulmonary adenocarcinoma in mice.Jan 31, 2010

Dietary indole-3-carbinol alleviated spleen enlargement, enhanced IgG response in C3H/HeN mice infected with Citrobacter rodentium.Oct 14, 2020

Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin.Mar 31, 2011

Immunoregulatory effects of indole-3-carbinol on monocyte-derived macrophages in systemic lupus erythematosus.Jul 31, 2018

In vivo pharmacodynamics of indole-3-carbinol in the inhibition of prostate cancer in transgenic adenocarcinoma.Sep 30, 2012

Indole-3 carbinol inhibits lung tumorigenesis and DNA methylation.May 01, 1990

Indole-3 carbinol prevents human papilloma virus induced cervical cancer and cervical dysplasia in transgenic mice.Aug 15, 1999

Indole-3 carbinol reverses multidrug resistant melanoma in vivo. Feb 01, 1996

Indole-3 carbinol, a compound found in cabbage, may prevent and treat breast cancer bone metastasis. Nov 01, 2006

Indole-3-carbinol affects murine leukemia WEHI-3 cells both in vitro and in vivo.Aug 07, 2012

Indole-3-carbinol ameliorated the isoproterenol-induced myocardial infarction.Feb 16, 2022

Indole-3-carbinol ameliorated the thioacetamide-induced hepatic encephalopathy.Jun 14, 2023

Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats.Dec 31, 2013

Indole-3-carbinol diminishes proliferation and increases apoptosis of tumor cells in an experimental model of inflammatory breast cancer.Jun 03, 2018

Indole-3-carbinol enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin.Jun 24, 2018

Indole-3-carbinol has anti-proliferative effects in human breast cancer cells.Sep 11, 2014

Indole-3-carbinol improves neurobehavioral symptoms in a cerebral ischemic stroke model.Dec 31, 2017

Indole-3-carbinol inhibited the growth of nasopharyngeal carcinoma cells and induced apoptosis effectively in vivo and in vitro.Aug 04, 2016

Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma.Nov 30, 2011

Indole-3-carbinol inhibits cell proliferation and induces apoptosis in Hep-2 laryngeal cancer cells.Jun 30, 2013

Indole-3-carbinol inhibits lipid deposition and promotes autophagy in hyperlipidemia.Jul 31, 2019

Indole-3-carbinol inhibits LPS-induced inflammatory response by blocking TRIF-dependent signaling pathway in macrophages.Jun 30, 2013

Indole-3-carbinol inhibits nasopharyngeal carcinoma cell growth.Jun 30, 2014

Indole-3-carbinol inhibits nasopharyngeal carcinoma growth through cell cycle arrest in vivo and in vitro.Dec 31, 2012

Indole-3-carbinol inhibits the growth of endometriotic lesions.Nov 20, 2022

Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells.Dec 31, 2014

Indole-3-carbinol is a potent inhibitor of ischemia-reperfusion-induced inflammation.Jun 30, 2017

Indole-3-carbinol is a powerful treatment to reduce impact of clostridium difficile infection in mice.Jun 07, 2016

Indole-3-carbinol mitigates oxidative stress and inhibits inflammation in rat cerebral ischemia/reperfusion model.Sep 30, 2023

Indole-3-carbinol prevented ethanol-induced liver injury via attenuating the damaging effect of ethanol on the gut-liver-adipose tissue axis.Apr 30, 2018

Indole-3-carbinol prevents colitis and associated microbial dysbiosis in an IL-22-dependent manner.Jan 15, 2020

Indole-3-carbinol prevents the loss of the tumor suppressor gene PTEN in cervical cancer in vivo.Jan 01, 2011

Indole-3-carbinol provides protection against cisplatin-induced nephrotoxicity.Jul 14, 2016

Indole-3-carbinol selectively prevents chronic stress-induced depression.Dec 31, 2021

Indole-3-carbinol supports oral tolerance against OVA and improves peanut allergy symptoms in mice.Dec 31, 2016

Indole-3-carbinol would be effective for enhancing sensitivity of pancreatic cancer cells to gemcitabine.Mar 31, 2013

Indoles can effectively suppress acute hepatic inflammation caused by Staphylococcal enterotoxin B.Dec 31, 2014

Intranasal administration of Indole-3-carbinol liposomes led to a 100-fold higher lung exposure than the oral route of administration.Dec 29, 2014

Involvement of SIRT1-AMPK signaling in the protective action of indole-3-carbinol against hepatic steatosis in mice fed a high-fat diet.Jun 30, 2013

Linagliptin and indole-3-carbinol combination might represent a beneficial therapeutic modality for amelioration of polycystic ovarian syndrome.Jul 31, 2017

Nanocapsules improve indole-3-carbinol photostability and prolong its antinociceptive action in acute pain models.Dec 31, 2017

Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease.Jan 14, 2022

OSU-A9, an indole-3-carbinol derivative, induces cytotoxicity in acute myeloid leukemia.Nov 14, 2013

Protective effect of Indole-3-carbinol, an NF-κB inhibitor in experimental paradigm of Parkinson's disease.Oct 31, 2020

The gut metabolite indole-3 propionate promotes nerve regeneration and repair.Jun 30, 2022

Therapeutic benefits of Indole-3-Carbinol in adjuvant-induced arthritis and its protective effect against methotrexate induced-hepatic toxicity.Dec 18, 2018

Therapeutic effect of indole-3-carbinol on pig serum-induced hepatic fibrosis in rats.Jul 31, 2011

These findings suggest that Indole-3-carbinol has a potential benefit in preventing obesity and metabolic disorders.Nov 30, 2012

These results demonstrated that indole-3-carbinol could induce apoptosis of hepatic stellate cells.Dec 31, 2016

These results showed the potential lung cancer chemopreventive effects of I3C + Sil in smokers/former smokers with chronic pulmonary inflammatory conditions.May 31, 2015

These results unraveled complex relationships among indole-3-carbinol ingestion, gut microbiota, and prostate tumor development.Feb 21, 2019

This study suggests that Indole-3-carbinol has promising chemoprotective efficacy against doxorubicin-induced toxicities.Apr 30, 2018

1-Benzyl-indole-3-carbinol is a highly potent new small molecule inhibitor of Wnt/β-catenin signaling in melanoma cells.Jan 06, 2017

3,3'-diindolylmethane (DIM) has multiple anticancer properties making it one of the most hopeful phytochemicals in treating and preventing prostate cancer and HGPIN.Aug 31, 2014

3,3'-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment.Aug 25, 2023

Anticarcinogenic effect of indole-3-carbinol on human hepatocellular carcinoma SNU449 cells.Dec 31, 2018

BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.Feb 12, 2006

Broccoli-derived phytochemicals indole-3-carbinol and 3,3'-diindolylmethane exerts concentration-dependent pleiotropic effects on prostate cancer cells.Feb 29, 2012

Chemoprevention of prostate cancer by natural agents: evidence from molecular and epidemiological studies.Sep 30, 2019

Combination of fenretinide and indole-3-carbinol results in synergistic cytotoxic activity inducing apoptosis against human breast cancer cells.Jun 30, 2013

Cruciferous vegetable-derived indole-3-carbinol prevents coronavirus cell egression mechanisms in tracheal and intestinal 3D in vitro models.Jul 31, 2023

Enhanced efficacy of gemcitabine by indole-3-carbinol in pancreatic cell lines.Sep 30, 2011

Enhanced photostability, radical scavenging and antitumor activity of indole-3-carbinol-loaded rose hip oil nanocapsules.Apr 30, 2017

Glucosinolate-degradation products as co-adjuvant therapy on prostate cancer in vitro.Oct 08, 2019

Indole-3-Carbinol

View the Evidence:
128 Abstracts with Indole-3-Carbinol Research