Isoflavones

Name	AC	CK
Breast Cancer	27	77
Prostate Cancer	12	77
Osteoporosis	7	64
Endothelial Dysfunction	9	59
Postmenopausal Disorders	5	52
Menopausal Syndrome	6	51
Inflammation	18	45
C-Reactive Protein	5	42
Perimenopausal Syndrome	4	42
Mastalgia	2	31
Hot Flash	2	30
Cardiovascular Diseases	7	27
Lung Cancer	5	25
Coronary Artery Disease	3	24
Aging Skin	4	23
Hypertension	4	23
Lipopolysaccharide-Induced Toxicity	9	21
Stroke	3	21
Cardiac Mortality	1	20
Diabetes Mellitus: Type 2: Prevention	1	20
Hemodialysis	2	20
Hypothyroidism	1	20
Prostate: PSA Doubling	2	20
Smoking	2	20
Arteriosclerosis	3	14
Bladder Cancer	4	14
Estrogen Deficiency	3	14
Cholesterol: Oxidation	2	13
Hyperglycemia	2	13
Oxidative Stress	9	13
Androgen-Induced Diseases	2	12
Cerebral Ischemia	2	12
Endometrial Cancer	3	12
Infertility: Male	2	12
Ovarian Cancer	3	12
Cancers: Drug Resistant	2	11
Prostatic Hyperplasia: Benign	2	11
Rotavirus Infections	2	11
Abdominal Obesity (Midsection Fat)	1	10
Allergic Rhinitis	1	10
Alopecia	1	10
Angina Pectoris	1	10
Arterial Hardening: Elasticity	1	10
Atherosclerosis	1	10
COPD	1	10
Chemotherapy Induced Myelotoxicity	1	10
Dry Skin	1	10
Fibrocystic Breast Disease	1	10
Fibroids: Uterine	1	10
Hip Fracture	1	10
Infant Infections	1	10
Kidney Failure	1	10
Lower Urinary Tract Symptoms	1	10
Memory Loss	1	10
Myocardial Infarction	1	10
Obesity	5	10
Periodontal Diseases	1	10
Premenstrual syndrome	1	10
Prostate Cancer: Prevention	1	10
Radiation Induced Illness	1	10
Vaginal Atrophy	1	10
Vaginal Diseases	1	10
Diabetes Mellitus: Type 2	5	8
Colon Cancer	4	6
Fatty Liver	3	6
Insulin Resistance	4	6
Liver Cancer	4	6
Estrogen Dominance	4	5
Parkinson's Disease	3	5
Asthma	2	4
Cancer Metastasis	2	4
Cancers: All	4	4
Intima Media Thickening	2	4
Learning disorders	2	4
Metabolic Syndrome X	3	4
Neurodegenerative Diseases	3	4
Osteoarthritis	2	4
Prenatal Nutrition: Health of the Offspring	2	4
Pyrethroid Insecticide Induced Toxicity	2	4
Thrombosis	2	4
Atopic Dermatitis	2	3
Cadmium Poisoning	1	3
Candida Albicans	3	3
Cervical Cancer	3	3
Chemotherapy-Induced Toxicity: Cisplatin	3	3
Lung Damage	2	3
Musculoskeletal Diseases	1	3
Nonalcoholic fatty liver disease (NAFLD)	2	3
Pesticide Toxicity	3	3
Staphylococcus aureus: Methicillin-resistant (MRSA)	3	3
Acetaminophen (Tylenol) Toxicity	1	2
Adiponectin: Low Levels	1	2
Aging	1	2
Aging: Immunosenecence	1	2
Alcohol Toxicity	1	2
Allergies	1	2
Alzheimer's Disease	1	2
Aneurysm: Aortic	1	2
Arterial Plaque	1	2
Autoimmune Diseases	1	2
Benzo[a]pyrene-induced Toxicity	1	2
Breast Cancer: Chemically-Induced	1	2
Breast Cancer: Metastatic	1	2
Breast Cancer: Prevention	1	2
Breast Cancer: Triple Negative	2	2
Cancers: Multi-Drug Resistant	2	2
Carcinoma: Non-Small-Cell Lung	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Cognitive Decline/Dysfunction	1	2
Colitis	1	2
Dementia	1	2
Depression	1	2
Dermatitis: Contact	1	2
Diabetic Nephropathy	1	2
Encephalopathy	1	2
Fatigue: Excercise-Induced	1	2
Fungal Infection	2	2
Gastric Cancer	2	2
Gastrointestinal Inflammation	1	2
Glioma	2	2
Gliomas	1	2
Heart Failure	1	2
Hepatoma	1	2
High Cholesterol	1	2
Hormone Replacement Therapy	1	2
Hypertension: Pulmonary	1	2
Infant Nutrition	1	2
Inflammatory Bowel Diseases	1	2
Liver Damage: Drug-Induced	1	2
Lupus Erythematosus: Systemic	1	2
Memory Disorders	1	2
Metabolic Diseases	1	2
Muscle Atrophy	1	2
Osteopenia	1	2
Osteoporosis: Inflammation Induced	1	2
Osteoporosis: Male	1	2
Overactive Bladder	1	2
Pancreatic Cancer	2	2
Peripheral Nerve Diseases	1	2
Polio	1	2
Postmenopausal Disorders: Weight Gain/Obesity	1	2
Prenatal Chemical Exposures	1	2
Prostatitis: Acute	1	2
Prostatitis: Chronic	1	2
Psoriasis	1	2
Sepsis	1	2
Sperm Quality: Low	1	2
Sunburn	1	2
Testosterone: Too Low	1	2
Ulcerative Colitis	1	2
Uterine Cancer	1	2
5alpha-dihydrotestosterone (DHT): Elevated Levels/Activity	1	1
Acidosis	1	1
Anxiety	1	1
Aspergillosis	1	1
BRCA1/BRCA2: Prevalence	1	1
Benzene Toxicity	1	1
Brain Cancer	1	1
Brain Inflammation	1	1
Brain Ischemia	1	1
Brain: Microglial Activation	1	1
Cancer Stem Cells	1	1
Cancers	1	1
Candida Glabrata	1	1
Candida Infection	1	1
Cystic Fibrosis	1	1
Drug Toxicity: Methotrexate	1	1
Glioblastoma	1	1
HIV Drug-Induced Toxicity	1	1
Helicobacter Pylori Infection	1	1
Homocysteine: Elevated	1	1
Kidney Cancer	1	1
Kidney Damage: Drug-Induced	1	1
Lymphoma	1	1
Optic Nerve Diseases	1	1
Oral Cancer	1	1
Oral Submucous Fibrosis	1	1
Osteonecrosis	1	1
Osteosarcoma	1	1
Plasmodium Infections	1	1
Promyelocytic leukemia	1	1
Spinal Cord Injuries	1	1
Squamous cell carcinoma	1	1
Staphylococcal Infections	1	1
Stomach Cancer	1	1
Thyroid Cancer	1	1
Ultraviolet Radiation Induced Damage	1	1
Urinary Tract Cancer	1	1
Xenobiotic Exposures	1	1

Name	AC	CK
Chemopreventive	13	86
Anti-Inflammatory Agents	26	50
Apoptotic	34	50
Antioxidants	18	45
Antiproliferative	30	40
Osteoprotective	3	32
Antineoplastic Agents	11	31
Cardioprotective	7	29
Tumor Necrosis Factor (TNF) Alpha Inhibitor	11	26
Hypolipidemic	3	24
Interleukin-6 Downregulation	4	22
Hypoglycemic Agents	7	21
NF-kappaB Inhibitor	8	21
Neuroprotective Agents	12	20
Anticarcinogenic Agents	9	19
Antiviral Agents	3	13
Matrix metalloproteinase-2 (MMP-2) inhibitor	3	13
Anticholesteremic Agents	2	12
Gastrointestinal Agents	2	12
Cell cycle arrest	8	10
Photoprotective	1	10
Vascular Cell Adhesion Molecule-1 Inhibitor	1	10
Interleukin-1 beta downregulation	6	9
Anti-Apoptotic	5	7
Anti-metastatic	4	7
Antifungal Agents	7	7
Anti-Bacterial Agents	6	6
Interleukin-18 down-regulation	4	6
Chemoprotective Agents	4	5
Chemosensitizer	4	5
Hepatoprotective	3	5
Angiogenesis Inhibitors	3	4
Chemotherapeutic	4	4
Malondialdehyde Down-regulation	2	4
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	4
MicroRNA modulator	3	4
Renoprotective	3	4
Superoxide Dismutase Up-regulation	2	4
Autophagy Up-regulation	2	3
Cyclooxygenase 2 Inhibitors	2	3
Enzyme Inhibitors	2	3
Insulin-Like Growth Factor Inhibition/Downregulation	2	3
Tumor Suppressor Protein p53 Upregulation	2	3
Vasodilator Agents	2	3
Alpha-glucosidase inhibitor	1	2
Analgesics	1	2
Anti-Angiogenic	1	2
Anti-thrombotic	1	2
Antidepressive Agents	1	2
Antinoceceptive	1	2
Chondroprotective	1	2
Estradiol 3-glucuronide enhancer	2	2
Gene Protective	1	2
Interleukin-10 upregulation	1	2
Lipolytic	1	2
Lipoxygenase Inhibitors	1	2
Neuritogenic	1	2
Nitric Oxide Enhancer	1	2
Nrf2 activation	1	2
Osteogenic	1	2
Platelet Aggregation Inhibitors	1	2
Stearoyl coenzyme A desaturase-1 modulator	1	2
Transforming growth factor beta (TGF-β) upregulation	1	2
Vascular Endothelial Growth Factor Inhibitors	1	2
Anti-Androgen	1	1
Anti-Fibrotic	1	1
Anti-atherogenic	1	1
Antimutagenic Agents	1	1
Antiparasitic Agents	1	1
Arginase 1 (Arg1) up-regulation	1	1
Bcl-2 protein down-regulation	1	1
Caspase-7 Activation	1	1
Caspase-9 Activation	1	1
Cytotoxic	1	1
GABA Modulators	1	1
Glucagon Like peptide 1 (GLP-1) Up-regulation	1	1
Hypnotics and Sedatives	1	1
Insulinotrophic	1	1
Malonaldehyde (MDA) Down-Regulation	1	1
Neocardiogenic	1	1
Nitric Oxide Inhibitor	1	1
P21 Activation	1	1
Topoisomerase I inhibitor	1	1
Topoisomerase II Inhibitor	1	1
Transforming growth factor beta (TGF-β) inhibitor	1	1
Vascular Endothelial Growth Factor Regulator	1	1

[+]

The effectiveness of herbal medicines on cyclic mastalgia.Sep 30, 2022

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Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women.Aug 31, 2017

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Pubmed Data : Am J Clin Nutr. 2017 Sep ;106(3):909-920. Epub 2017 Aug 2. PMID: 28768651

Article Published Date : Aug 31, 2017

Study Type : Human Study

Additional Links

Substances : Isoflavones, Probiotics, Red Clover

Diseases : Osteoporosis, Postmenopausal Disorders

Pharmacological Actions : Osteoprotective

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Combined red clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms.Dec 31, 2016

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[+]

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Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2007 Feb;53(1):57-62. PMID: 17484381

Article Published Date : Feb 01, 2007

Study Type : Human Study

Additional Links

Substances : Beta-glucan, Isoflavones, Soy

Diseases : Aging Skin

[+]

Puerarin acts as an anti-inflammatory agent by blocking NF-kappaB signalling.Jul 31, 2010

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Pubmed Data : Basic Clin Pharmacol Toxicol. 2010 Aug ;107(2):637-42. Epub 2010 Mar 22. PMID: 20346059

Article Published Date : Jul 31, 2010

Study Type : Human Study

Additional Links

Substances : Isoflavones

Diseases : Angina Pectoris, Atherosclerosis, C-Reactive Protein, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

Additional Keywords : Plant Extracts

[+]

Quercetin and isoflavone intake is associated with a reduced risk for endometrial cancer. Sep 01, 2009

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Pubmed Data : Cancer Causes Control. 2009 Sep;20(7):1117-27. Epub 2009 Apr 8. PMID: 19353280

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Substances : Isoflavones, phytoestrogens, Quercetin

Diseases : Endometrial Cancer

[+]

Red clover isoflavones enriched with formononetin lowers serum LDL cholesterol.Dec 31, 2014

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Pubmed Data : Eur J Clin Nutr. 2015 Jan ;69(1):134-42. Epub 2014 Nov 5. PMID: 25369831

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Isoflavones, Red Clover

Diseases : Menopausal Syndrome

Pharmacological Actions : Anticholesteremic Agents

Additional Keywords : Plant Extracts

[+]

Additional Keywords : Risk Reduction

[+]

Soy formula and soy isoflavone consumption is associated with reduced rotavirus infectivity. Nov 01, 2009

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Pubmed Data : Nutr Rev. 2009 Nov;67 Suppl 2:S192-200. PMID: 19906223

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Pubmed Data : Clin Nutr ESPEN. 2022 Dec ;52:158-168. Epub 2022 Oct 26. PMID: 36513449

Article Published Date : Nov 30, 2022

Study Type : Human Study

Additional Links

Substances : Isoflavones, Soy

Diseases : Breast Cancer

Pharmacological Actions : Chemopreventive

[+]

Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause.Apr 09, 2018

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Pubmed Data : Nutr Metab Cardiovasc Dis. 2018 Apr 10. Epub 2018 Apr 10. PMID: 29739677

Article Published Date : Apr 09, 2018

Study Type : Human Study

Additional Links

Substances : Isoflavones, Soy

Diseases : Cardiovascular Diseases, Menopausal Syndrome

Pharmacological Actions : Cardioprotective

Additional Keywords : Risk Reduction

[+]

Soy isoflavones may benefit some patients with prostate cancer. Jan 01, 2003

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Pubmed Data : Nutr Cancer. 2003;47(2):111-7. PMID: 15087261

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Pubmed Data : Nutr Neurosci. 2008 Dec;11(6):251-62. PMID: 19000378

Article Published Date : Dec 01, 2008

Study Type : Human Study

Additional Links

Substances : Isoflavones, phytoestrogens, Soy

Diseases : Memory Loss

[+]

Soy product consumption is inversely associated with the risk for hip fracture in men and women. Oct 01, 2009

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Pubmed Data : Am J Epidemiol. 2009 Oct 1;170(7):901-9. Epub 2009 Aug 31. PMID: 19720865

Article Published Date : Oct 01, 2009

Study Type : Human Study

Additional Links

Substances : Isoflavones, Soy

Diseases : Hip Fracture, Osteoporosis

Additional Keywords : Risk Reduction

[+]

Soy protein containing isoflavones improves facial figns of photoaging and skin hydration.Sep 22, 2023

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Pubmed Data : Int J Cancer. 2008 Aug 1 ;123(3):664-71. PMID: 18491403

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Pubmed Data : Mol Med Rep. 2013 Apr ;7(4):1278-82. Epub 2013 Feb 19. PMID: 23426874

Article Published Date : Mar 31, 2013

Study Type : Animal Study

Additional Links

Substances : Isoflavones

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

[+]

A combination of caffeine, arginine, soy isoflavones, and L-carnitine enhances both lipolysis and fatty acid oxidation in animal model of obesity. Oct 01, 2007

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Pubmed Data : J Nutr. 2007 Oct;137(10):2252-7. PMID: 17885007

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Pubmed Data : J Med Food. 2008 Jun;11(2):215-23. PMID: 18598161

Article Published Date : Jun 01, 2008

Study Type : Animal Study

Additional Links

Substances : Fermented Foods and Beverages, Isoflavones, Soy Protein

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents

[+]

AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity.Jun 30, 2012

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Pubmed Data : Molecules. 2021 Jul 7 ;26(14). Epub 2021 Jul 7. PMID: 34299411

Article Published Date : Jul 06, 2021

Study Type : Animal Study

Additional Links

Substances : Butterfly Pea, Flavonoids, Isoflavones

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Plant Extracts

[+]

Coffee contains the isoflavones genistein, daidzein and formononetin.Mar 10, 2010

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Pubmed Data : J Agric Food Chem. 2010 Mar 10;58(5):3002-7. PMID: 20131840

Article Published Date : Mar 10, 2010

Study Type : Animal Study

Additional Links

Substances : Coffee, Daidzein, Genistein, Isoflavones

Additional Keywords : Substances that are Linked

[+]

Additional Keywords : Bone Regeneration

[+]

Formononetin protects against acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.Dec 31, 2016

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Pubmed Data : Pulm Pharmacol Ther. 2020 08 ;63:101936. Epub 2020 Aug 9. PMID: 32783990

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Isoflavones

Diseases : Asthma, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Glabridin attenuates colonic inflammation in mice.Dec 31, 2007

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Pubmed Data : J Environ Sci Health B. 2003 Jul;38(4):463-78. PMID: 12856928

Article Published Date : Jul 01, 2003

Study Type : Animal Study

Additional Links

Substances : Isoflavones

Diseases : Infertility: Male, Pyrethroid Insecticide Induced Toxicity, Sperm Quality: Low, Testosterone: Too Low

[+]

MiR-34a-5p/Sirt1 axis: A novel pathway for puerarin-mediated hepatoprotection against benzo(a)pyrene.May 31, 2022

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Pubmed Data : Free Radic Biol Med. 2022 Jun ;186:53-65. Epub 2022 May 10. PMID: 35561843

[+]

Soy has an anti-inflammatory effect on experimentally-induced prostatitis in rats. May 01, 2007

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Pubmed Data : Exp Biol Med (Maywood). 2007 May;232(5):674-81. PMID: 17463164

Article Published Date : May 01, 2007

Study Type : Animal Study

Additional Links

Substances : Daidzein, Genistein, Isoflavones, Soy Protein

Diseases : Prostatitis: Acute, Prostatitis: Chronic

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Soy isoflavone may ameliorate insulin sensitivity by decreasing visceral adipose deposition and adjusting low-grade inflammatory molecules derived from white adipose tissue.Sep 05, 2003

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Pubmed Data : Life Sci. 2003 Sep 5;73(16):2127-36. PMID: 17062358

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Pubmed Data : Lupus. 2008 Sep;17(9):814-21. PMID: 18755863

Article Published Date : Sep 01, 2008

Study Type : Animal Study

Additional Links

Substances : Genistein, Isoflavones

Diseases : Autoimmune Diseases, Lupus Erythematosus: Systemic

[+]

Soy meal is a potential alternative to estrogen in the prevention and treatment of Alzheimer's disease.Apr 15, 2008

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Pubmed Data : Pak J Biol Sci. 2008 Apr 15;11(8):1114-9. PMID: 18819549

Article Published Date : Apr 15, 2008

Study Type : Animal Study

Additional Links

Substances : Isoflavones, Soy

Diseases : Alzheimer's Disease, Dementia, Estrogen Deficiency, Learning disorders

Additional Keywords : Natural Substances Versus Drugs, Ovariectomy-Induced Changes

[+]

Soy meal may have the potential neuroprotective effect against post-menopausal cognitive deficiency and weight gain.Oct 15, 2009

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Pubmed Data : Pak J Biol Sci. 2009 Oct 15;12(20):1338-45. PMID: 20128500

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Pubmed Data : J Nutr. 2005 Dec;135(12):2852-6. PMID: 16317131

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Pubmed Data : Adv Mater. 2022 Sep ;34(39):e2204976. Epub 2022 Sep 1. PMID: 35973230

Article Published Date : Aug 31, 2022

Study Type : Animal Study

Additional Links

Substances : Isoflavones, Licorice

Diseases : Cerebral Ischemia

Pharmacological Actions : Neuroprotective Agents

[+]

The isoflavone daidzein reduces food intake, weight gain and reduces fat content in the livers of animals on an obesity-generating diet. May 10, 2011

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Pubmed Data : Br J Pharmacol. 2011 May 10. Epub 2011 May 10. PMID: 21557739

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Pubmed Data : J Ethnopharmacol. 2019 Oct 5 ;242:111699. Epub 2019 Apr 18. PMID: 31005632

Article Published Date : Oct 04, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Formononetin, Isoflavones

Diseases : Gliomas

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Temozolomide

[+]

A diet rich in a variety of fruits, vegetables, whole grains, legumes, oils, and nuts is recommended after a review of various studiesDec 29, 2002

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Pubmed Data : Am J Med. 2002 Dec 30 ;113 Suppl 9B:71S-88S. PMID: 12566142

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Pubmed Data : Dose Response. 2019 Apr-Jun;17(2):1559325819852243. Epub 2019 May 26. PMID: 31205459

Article Published Date : Mar 31, 2019

Study Type : Review

Additional Links

Substances : Catechin , Diosgenin, Isoflavones, Quercetin, Sulforaphane

Diseases : Cardiovascular Diseases

Pharmacological Actions : Cardioprotective

[+]

A review of the role of phytochemicals in cancer prevention.Oct 08, 2019

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Pubmed Data : Life Sci. 2008 Aug 15;83(7-8):293-300. Epub 2008 Jun 28. PMID: 18640131

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Pubmed Data : J Neurosci. 2010 Jan 13;30(2):739-48. PMID: 20071539

Article Published Date : Jan 13, 2010

Study Type : In Vitro Study

Additional Links

Substances : Daidzein, Isoflavones

Diseases : Optic Nerve Diseases, Spinal Cord Injuries, Stroke

Pharmacological Actions : Arginase 1 (Arg1) up-regulation, Enzyme Inhibitors, Neuroprotective Agents

[+]

DIM and isoflavone may lead to the reversal of a gemcitabine-resistant pancreatic cancer phenotype. Aug 15, 2009

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Pubmed Data : Cancer Res. 2009 Aug 15;69(16):6704-12. Epub 2009 Aug 4. PMID: 19654291

Article Published Date : Aug 15, 2009

Study Type : In Vitro Study

Additional Links

Substances : Isoflavones

Diseases : Pancreatic Cancer

Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Epigenetic Modification

[+]

Effect of licorice compounds licochalcone A, glabridin and glycyrrhizic acid on growth and virulence properties of Candida albicans.Oct 31, 2011

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Pubmed Data : Front Microbiol. 2020 ;11:1779. Epub 2020 Sep 17. PMID: 33071991

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Isoflavones

Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)

Pharmacological Actions : Anti-Bacterial Agents

[+]

Glabridin induces apoptosis and autophagy through JNK1/2 pathway in human hepatoma cells.Apr 14, 2016

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Pubmed Data : Phytomedicine. 2016 Apr 15 ;23(4):359-66. Epub 2016 Feb 13. PMID: 27002406

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Pubmed Data : J Glob Antimicrob Resist. 2017 12 ;11:52-56. Epub 2017 Aug 24. PMID: 28844974

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Pubmed Data : J Gen Appl Microbiol. 2021 Dec 31 ;67(6):269-272. Epub 2021 Oct 23. PMID: 34690227

Article Published Date : Dec 30, 2021

Study Type : In Vitro Study

Additional Links

Substances : Isoflavones

Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

Glabridin triggers over-expression of apoptosis inducing factor (AIF) gene in Candida albicans.Aug 31, 2018

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Pubmed Data : Drug Dev Res. 2019 Aug ;80(5):573-584. Epub 2019 Mar 27. PMID: 30916421

Article Published Date : Jul 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Isoflavones, NAC (N-acetyl-L-cysteine)

Diseases : Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, NF-kappaB Inhibitor

[+]

In vitro anti-Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action.Jan 29, 2013

Pubmed Data : Phytother Res. 2015 Feb ;29(2):210-9. Epub 2014 Oct 7. PMID: 25287332

Article Published Date : Jan 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Chickpea, Isoflavones

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-7 Activation , Caspase-9 Activation, Chemopreventive, P21 Activation, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Dose Response, Plant Extracts

[+]

Isoflavones isolated from the seeds of Millettia ferruginea induced apoptotic cell death in human ovarian cancer cells.Jan 02, 2020

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Pubmed Data : Biochem Biophys Res Commun. 2009 Jan 23;378(4):683-8. Epub 2008 Nov 14. PMID: 19013426

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Pubmed Data : Phytother Res. 2023 Jun ;37(6):2693-2737. Epub 2023 May 17. PMID: 37195042

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Pubmed Data : Menopause. 2008 Nov-Dec;15(6):1120-31. PMID: 18724264

Article Published Date : Nov 01, 2008

Study Type : Commentary

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Substances : Isoflavones, Red Clover

Diseases : Menopausal Syndrome, Metabolic Syndrome X

Additional Keywords : Plant Extracts

[+]

Red Clover isoflavones induce programmed cell death in human prostate cells.Dec 01, 2002

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Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1689-96. PMID: 12496063

Pubmed Data : Int J Mol Sci. 2016 Aug 31 ;17(9). Epub 2016 Aug 31. PMID: 27589739

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2014 ;9(7):e103442. Epub 2014 Jul 24. PMID: 25058485

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Isoflavones

Diseases : Candida Infection

Pharmacological Actions : Antifungal Agents

Additional Keywords : Natural Substance/Drug Synergy

[+]

The combinatory effects of glabridin and tamoxifen on Ishikawa and MCF-7 cell lines.Aug 31, 2015

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Pubmed Data : Nat Prod Commun. 2015 Sep ;10(9):1573-6. PMID: 26594762

Article Published Date : Aug 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Isoflavones

Diseases : Breast Cancer, Endometrial Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Synergy with Tamoxifen

[+]

The isoflavone content of soybeans increases during germination. Sep 01, 2005

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Pubmed Data : Plant Foods Hum Nutr. 2005 Sep;60(3):147-51. PMID: 16187018

Article Published Date : Sep 01, 2005

Study Type : In Vitro Study

Additional Links

Substances : Daidzein, Genistein, Isoflavones, Sprouts

[+]

The isoflavones biochanin A and genistein inhibit the cell growth of stomach cancer lines by inducing programmed cell death. Dec 01, 1993

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Pubmed Data : Cancer Res. 1993 Dec 1;53(23):5815-21. PMID: 8242641

Article Published Date : Dec 01, 1993

Study Type : In Vitro Study

Additional Links

Substances : Biochanin A, Genistein, Isoflavones

Diseases : Stomach Cancer

Pharmacological Actions : Apoptotic

[+]

The isoflavones biochanin A, daidzein and especially genistein inhibit the growth of breast cancer cells, including those expressing the multi-drug resistance gene.Aug 30, 1991

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Pubmed Data : Biochem Biophys Res Commun. 1991 Aug 30;179(1):661-7. PMID: 1883387

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Cancer. 2017 05 2 ;17(1):307. Epub 2017 May 2. PMID: 28464803

Article Published Date : Jan 01, 2017

Study Type : In Vitro Study

Additional Links

Substances : Isoflavones

Diseases : Breast Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Antineoplastic Agents, Chemotherapeutic, MicroRNA modulator

[+]

The results of this study revealed the promising cytotoxic role of glabridin on different carcinoma cells.Jul 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Adv Pharm Bull. 2019 Aug ;9(3):481-489. Epub 2019 Aug 1. PMID: 31592119

Click here to read the entire abstract

Pubmed Data : J Sep Sci. 2019 Mar ;42(6):1133-1143. Epub 2019 Feb 25. PMID: 30620132

View the Evidence: 252 Abstracts with Isoflavones Research

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The effectiveness of herbal medicines on cyclic mastalgia.Sep 30, 2022

A standardised extract of red clover isoflavones had a statistical and clinically significant benefit for treating hot flushes in menopausal women.Jan 14, 2017

Exposure to isoflavone-containing soy products may improve endothelial function. Aug 14, 2010

Higher intakes of total flavonoids and subclasses are associated with lower risk of T2DM.Apr 30, 2018

Red clover may have a beneficial effect on the lipid profile of perimenopausal and postmenopausal women.Jan 09, 2018

Safety Study: There is little evidence that in those with normal thyroid function soy has any adverse effects. In those with hypothyroidism adequate iodine should be consumed to counterbalance the soy consumption.Mar 01, 2006

Soy isoflavones prevent bone resorption and loss.Jul 09, 2019

A combination of soy, isoflavones, lycopene, silymarin and antoxidants significantly increases PSA doubling time in men with prostate cancer. Dec 01, 2005

A daily supplement of soy protein prevents the increase in subcutaneous and total abdominal fat in postmenopausal women. Dec 01, 2007

A high intake of soy and isoflavones may be associated with a reduced prevalence of allergic rhinitis.Jun 01, 2005

A higher intake of soy foods and soy isoflavones is associated with lower sperm concentration.Nov 01, 2008

A soy rich diet may prevent the vaginal atrophy in postmenopause. Jan 01, 2008

Capsaicin and isoflavone promotes hair growth in mice and humans with alopecia. Oct 01, 2007

Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women.Aug 31, 2017

Combined red clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms.Dec 31, 2016

Daidzein-rich isoflavone are effective in reducing hot flashes in menopausal women. Apr 24, 2007

Dietary intake of isoflavone is inversely associated with the risk of lower urinary tract symptoms. Dec 01, 2007

Dietary intake of isoflavones and polyunsaturated fatty acids associated with a Japanese diet reduce lung dysfunction, breathlessness and the prevalence of chronic obstructive pulmonary disease. Jan 28, 2010

Dietary intake of isoflavones is associated with a lower prevalence of subclinical cardiovascular disease in postmenopausal women.Jul 14, 2019

Dietary isoflavone consumption is inversely associated with fibrocystic breast disease. Dec 01, 2007

Dietary soy improves the inflammatory and nutritional status in end-stage renal disease patients on chronic hemodialysisAug 01, 2006

Effects of isoflavone-rich red clover extract on blood glucose level.Mar 31, 2021

Fermented soy therapy may have therapeutic value in treating platinum-resistant ovarian cancer. Jan 01, 2006

Fermented soymilk beneficially modifies the gut microbiota in premenopausal healthy women.Feb 26, 2018

Frequent miso soup and isoflavone consumption is associated with a reduced risk of breast cancer in Japanese women. Jun 18, 2003

Genistein and daidzein consumption are associated with a lower risk of prostate cancer. Aug 01, 2009

High dietary intake of soy isoflavones was associated with lower risk of recurrence among post-menopausal patients with breast cancer positive for estrogen and progesterone receptor and those who were receiving anastrozole (Arimidex) as endocrine therapy.Feb 01, 2010

High isoflavone intake is associated with reduced risk of cerebral and myocardial infarction in Japanese women.Nov 27, 2007

Isoflavone intake was associated with a decreased risk of lung cancer. Jan 13, 2010

Isoflavone supplementation improves menopausal symptoms only in women with the ability to produce equol.Jul 01, 2008

Isoflavone supplementation reduces C-reactive protein and reverses endothelial dysfunction in patients with ischaemic stroke.Nov 01, 2008

Isoflavone-rich soy protein suppresses androgen receptor expression in men at high risk of prostate cancer. Jul 01, 2007

Isoflavones attenuate bone loss and have a potentially protective effect on the lumbar spine in womenFeb 01, 2004

Isoflavones from soy foods have therapeutic value in treating perimenstrual symptoms. Apr 01, 2007

Isoflavones, taken orally, reduced blood pressure and central arterial stiffness indicating reduced cardiovascular risk.May 01, 2007

Isolfavones have therapeutic value in the treatment of cyclical mastalgia. Apr 01, 2002

Lycopene and soy isoflavones have activity in prostate cancer patients with PSA relapse disease and may delay progression of both hormone-refractory and hormone-sensitive prostate cancer.Jul 01, 2009

Oral intake of soy isoflavone aglycone improves the aged skin of adult women.Feb 01, 2007

Puerarin acts as an anti-inflammatory agent by blocking NF-kappaB signalling.Jul 31, 2010

Quercetin and isoflavone intake is associated with a reduced risk for endometrial cancer. Sep 01, 2009

Red clover isoflavones enriched with formononetin lowers serum LDL cholesterol.Dec 31, 2014

Regular consumption of soy isoflavones may protect against endothelial dysfunction.Jul 01, 2008

Safety Study: soybean isoflavone exposure does not have feminizing effects on men. May 01, 2010

Soy and isoflavone intake may decrease the likelihood of periodontal disease.Jan 01, 2008

Soy food intake has a protective role against premenopausal breast cancer.Jun 01, 2009

Soy formula and soy isoflavone consumption is associated with reduced rotavirus infectivity. Nov 01, 2009

Soy isoflavone consumption reduce symptoms of premenstrual syndrome. May 01, 2005

Soy isoflavones ameliorate the adverse effects of chemotherapy in children.Oct 01, 1996

Soy isoflavones and curcumin suppress PSA levels in human subjects. Jul 01, 2010

Soy isoflavones attenuate bone loss in early postmenopausal women. Sep 01, 2006

Soy isoflavones consumed at levels comparable to those in Asian populations may reduce the risk of cancer recurrence in women receiving tamoxifen therapy and moreover, appears not to interfere with tamoxifen efficacy.Nov 01, 2009

Soy isoflavones decrease fibroglandular breast tissue measured by magnetic resonance imaging in premenopausal women.Nov 30, 2022

Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause.Apr 09, 2018

Soy isoflavones may benefit some patients with prostate cancer. Jan 01, 2003

Soy isoflavones may have a beneficial effect on certain menstrual symptoms. Jun 01, 2006

Soy isoflavones taken in conjunction with radiation therapy could reduce the urinary, intestinal, and sexual adverse effects in patients with prostate cancer.Oct 01, 2010

Soy phytoestrogens may improve working memory through estrogen-independent mechanisms.Dec 01, 2008

Soy product consumption is inversely associated with the risk for hip fracture in men and women. Oct 01, 2009

Soy protein containing isoflavones improves facial figns of photoaging and skin hydration.Sep 22, 2023

Soy protein may prevent prostate cancer development. Jan 01, 2008

Soy protein reduces cholesterol oxidation in patients on hemodialysis. Jan 01, 2006

Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women.Jul 01, 2003

The hypotensive and anti-inflammatory effect of soy nut consumption may be due to a reduction in solube vascular cell adhesion molecule-1 which results in an improvement in endothelial function. Jul 01, 2008

There is a modest inverse association between lignan excretion and uterine fibroid risk. Jan 01, 2005

This data indicate an inverse association between isoflavones and flavones with respect to bladder cancer risk.Apr 30, 2019

This study provides further support for a beneficial effect of flavonoid intake on lung cancer riskJul 31, 2008

Irilone from red clover potentiates progesterone signaling.Jan 28, 2018

Cardiovascular protective effect of glabridin: Implications in LDL oxidation and inflammation.Nov 30, 2015

Glabridin induces glucose uptake via the AMP-activated protein kinase pathway in muscle cells.Aug 04, 2014

Glabridin inhibited the invasion of human liver cancer cells.May 31, 2014

Puerarin prevents cadmium-induced neuronal injury.May 04, 2023

Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus.Mar 31, 2013

Isoflavones

View the Evidence:
252 Abstracts with Isoflavones Research