Jujube

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68 Diseases Researched for Jujube
NameACCKFocus
Diabetes Mellitus: Type 2314Locked
Constipation110Locked
Inflammation610Locked
Lipopolysaccharide-Induced Toxicity610Locked
Urticaria110Locked
Chemically-Induced Liver Damage48Locked
Alzheimer's Disease36Locked
Cancers: All45Locked
Hypertension35Locked
Oxidative Stress45Locked
Colitis24Locked
Colorectal Cancer24Locked
Breast Cancer23Locked
Breast Cancer: Triple Negative 23Locked
Inflammatory Bowel Diseases23Locked
Liver Damage23Locked
Neurodegenerative Diseases23Locked
Obesity23Locked
Staphylococcus aureus infection33Locked
Acetaminophen (Tylenol) Toxicity 12Locked
Aging12Locked
Air Pollution Linked Toxicity12Locked
Asthma12Locked
Brain Injury: Traumatic12Locked
Chemotherapy-Induced Kidney Damage22Locked
Chemotherapy-Induced Toxicity: Cisplatin22Locked
Cognitive Decline/Dysfunction12Locked
DNA damage12Locked
Delirium12Locked
Diabetic Nephropathy12Locked
Diarrhea12Locked
Dyslipidemias12Locked
Epilepsy12Locked
Escherichia coli Infections22Locked
Febrile Seizures12Locked
High Fat Diet12Locked
High Fructose Diet12Locked
Hyperglycemia22Locked
Insomnia12Locked
Insulin Resistance12Locked
Liver Damage: Drug-Induced12Locked
Liver Disease12Locked
Lung Damage12Locked
Lung Injury: Acute12Locked
Memory Disorders12Locked
Myocardial Infarction12Locked
Osteoarthritis12Locked
Pesticide Toxicity 12Locked
Trigeminal Neuralgia12Locked
Triglycerides: Elevated12Locked
Wound Healing12Locked
Acute lymphoblastic leukemia (ALL)11Locked
Anemia11Locked
Aspergillosis11Locked
Candida Albicans11Locked
Cardiomyopathy11Locked
Cardiovascular Diseases11Locked
Central Nervous System Diseases11Locked
Diabetic Neuropathy11Locked
Leukemia11Locked
Listeria Infections11Locked
Liver Cancer11Locked
Lung Cancer11Locked
Parkinson's Disease11Locked
Photooxidative Stress11Locked
Prostate Cancer11Locked
Salmonella Infections11Locked
Ultraviolet Radiation Induced Damage11Locked
55 Pharmacological Actions Researched for Jujube
NameACCKFocus
Anti-Inflammatory Agents2340Locked
Antioxidants1729Locked
Hypolipidemic619Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor915Locked
Neuroprotective Agents814Locked
Hepatoprotective713Locked
Hypoglycemic Agents313Locked
Interleukin-1 beta downregulation712Locked
Anti-Apoptotic69Locked
Antiproliferative 68Locked
Apoptotic56Locked
Interleukin-6 Downregulation46Locked
Anti-Bacterial Agents45Locked
Antihypertensive Agents35Locked
Chemopreventive35Locked
Neuritogenic15Locked
Anticonvulsants24Locked
Cardioprotective34Locked
Gastrointestinal Agents24Locked
Gastroprotective24Locked
NF-kappaB Inhibitor34Locked
Renoprotective34Locked
Anticarcinogenic Agents23Locked
Cytoprotective23Locked
Heme oxygenase-1 up-regulation23Locked
Immunomodulatory23Locked
Nrf2 activation23Locked
Acetylcholinesterase Inhibitor12Locked
Adiponectin upregulation12Locked
Analgesics12Locked
Anti-Asthmatic Agents12Locked
Anti-metastatic12Locked
Anticholesteremic Agents12Locked
Antidiarrheals12Locked
Antimicrobial22Locked
Chemoprotective Agents22Locked
Cyclooxygenase 2 Inhibitors22Locked
Genoprotective12Locked
Interleukin-10 downregulation12Locked
Malondialdehyde Down-regulation12Locked
NF-E2-Related Factor-2 (Nrf2) Modulator12Locked
Superoxide Dismutase Up-regulation12Locked
Transforming growth factor beta (TGF-β) upregulation12Locked
Angiogenesis Inhibitors11Locked
Anti-Adipogenic11Locked
Antifungal Agents11Locked
Cell cycle arrest11Locked
Cytotoxic11Locked
Interleukin-8 downregulation11Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor11Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor11Locked
Nitric Oxide Inhibitor11Locked
Photoprotective11Locked
Tumor Suppressor Protein p53 Upregulation11Locked
Vascular Endothelial Growth Factor Regulator11Locked

View the Evidence:
69 Abstracts with Jujube Research

[+]

The effect of dried Ziziphus vulgaris on glycemic control, lipid profile, apo-proteins and hs-CRP in patients with type 2 diabetes mellitus.Mar 29, 2020

Pubmed Data : J Food Biochem. 2020 Mar 30:e13193. Epub 2020 Mar 30. PMID: 32227501
Article Published Date : Mar 29, 2020
Study Type : Human Study
Additional Links
Substances : Jujube
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic
[+]

Ziziphus jujuba extract is an effective and safe treatment for chronic constipation.Jan 01, 2008

Pubmed Data : Digestion. 2008;78(4):224-8. Epub 2009 Jan 13. PMID: 19142004
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Substances : Jujube
Diseases : Constipation
[+]

Ziziphus jujube syrup could be an effective adjuvant treatment for chronic spontaneous urticaria.Oct 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Med Sci. 2023 Nov ;48(6):582-590. Epub 2023 Nov 1. PMID: 38094286
Article Published Date : Oct 31, 2023
Study Type : Human Study
Additional Links
Substances : Jujube
Diseases : Urticaria
[+]

These results proposed the benefits of jujube in regulating expressions of neurotrophic factors and anti-oxidant enzymes in cultured astrocytes.Oct 31, 2014

Pubmed Data : Phytother Res. 2014 Nov ;28(11):1727-30. Epub 2014 Jul 28. PMID: 25066116
Article Published Date : Oct 31, 2014
Study Type : Human In Vitro
Additional Links
Substances : Jujube
Pharmacological Actions : Antioxidants, Neuritogenic
Additional Keywords : Dose Response, Plant Extracts
[+]

Jujuboside B inhibited high mobility group box protein 1-mediated severe inflammatory responses in human endothelial cells.Dec 31, 2022

Pubmed Data : J Med Food. 2023 Jan ;26(1):40-48. Epub 2022 Dec 19. PMID: 36576404
Article Published Date : Dec 31, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Jujube
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Molecular mechanisms of polysaccharides from Ziziphus jujuba Mill var. spinosa seeds regulating the bioavailability of spinosin and preventing colitis.Aug 01, 2020

Pubmed Data : Int J Biol Macromol. 2020 Aug 2 ;163:1393-1402. Epub 2020 Aug 2. PMID: 32755709
Article Published Date : Aug 01, 2020
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Colitis
Pharmacological Actions : Immunomodulatory
[+]

A jujube extract can reduce Aβ-induced toxicity in Caenorhabditis elegans.Jul 14, 2019

Pubmed Data : J Ethnopharmacol. 2019 Jul 15 ;239:111886. Epub 2019 Apr 23. PMID: 31026552
Article Published Date : Jul 14, 2019
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

A water extract of the leaves of Z. jujuba is efficacious for prevention and treatment of carbon tetrachloride induced hepatic injury in mice.Feb 21, 2017

Pubmed Data : Food Funct. 2017 Feb 22 ;8(2):816-822. PMID: 28124048
Article Published Date : Feb 21, 2017
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective
Additional Keywords : Plant Extracts
[+]

An aqueous macerate of Ziziphus jujuba reduces long-term spatial memory impairment.Aug 03, 2022

Pubmed Data : Metab Brain Dis. 2022 Aug 4. Epub 2022 Aug 4. PMID: 35922734
Article Published Date : Aug 03, 2022
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Memory Disorders
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Anti-inflammatory effects of Ziziphus Jujube on LPS-induced acute lung injury.Jun 15, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Allergy Asthma Immunol. 2023 Jun 16 ;22(3):281-289. Epub 2023 Jun 16. PMID: 37524664
Article Published Date : Jun 15, 2023
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Antiamnesic and neuroprotective effects of an aqueous extract of Ziziphus jujuba.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:5577163. Epub 2021 Aug 10. PMID: 34422074
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
Additional Keywords : Natural Substances Versus Drugs
[+]

Chokeberry and dried jujube could be used in the management of dyslipidemia and insulin resistance associated with metabolic syndrome Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Metab (Lond). 2019 ;16:38. Epub 2019 Jun 3. PMID: 31171927
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Chokeberry, Jujube
Diseases : Dyslipidemias, High Fat Diet, High Fructose Diet, Insulin Resistance
Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic
[+]

Dietary hydrolyzed jujube extract can reduce benzo(a)pyrene-induced lung inflammation.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2020 Aug 1 ;9(8). Epub 2020 Aug 1. PMID: 32752184
Article Published Date : Jul 31, 2020
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cytoprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Plant Extracts
Problem Substances : Benzo(a)pyrene
[+]

Dietary jujuba fruit attenuates colitis-associated tumorigenesis.May 27, 2019

Pubmed Data : Nutr Cancer. 2019 May 28:1-13. Epub 2019 May 28. PMID: 31135224
Article Published Date : May 27, 2019
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Colitis, Colorectal Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

Effect of training with or without Jujuba extract on cardiokines in heart tissue of myocardial infarcted rats.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Prev Med. 2019 ;10:103. Epub 2019 Jun 7. PMID: 31360350
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Myocardial Infarction
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective
[+]

Effects of Ziziphus Jujuba extract alone and combined with Boswellia serrata extract on monosodium Iodoacetate model of osteoarthritis.Nov 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Pharm Res. 2022 Dec ;21(1):e134338. Epub 2023 Jan 30. PMID: 36896317
Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Substances : Frankincense, Jujube
Diseases : Osteoarthritis
[+]

Ethyl acetate and aqueous fractions of Ziziphus jujuba prevent acute hypertension induced by angiotensin II.Jan 18, 2019

Pubmed Data : Cardiovasc Hematol Disord Drug Targets. 2019 11 19. Epub 2019 Nov 19. PMID: 31746299
Article Published Date : Jan 18, 2019
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
Additional Keywords : Plant Extracts
[+]

Hepatoprotective effect of dried red jujube fruit extract against acetaminophen-induced acute hepatotoxicity.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cureus. 2023 Jan ;15(1):e33272. Epub 2023 Jan 2. PMID: 36606101
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Jujube fruit feeding extends lifespan and increases tolerance to environmental stresses.Feb 28, 2017

Pubmed Data : Biogerontology. 2017 Mar 1. Epub 2017 Mar 1. PMID: 28251407
Article Published Date : Feb 28, 2017
Study Type : Insect Study
Additional Links
Substances : Jujube
Diseases : Aging
[+]

Jujube, barberry and saffron have beneficial effects in diabetic rats and may be associated with increased adiponectin levels.Oct 31, 2015

Pubmed Data : Pak J Pharm Sci. 2015 Nov ;28(6):2095-9. PMID: 26639503
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Barberry, Jujube, Saffron
Diseases : Diabetes Mellitus: Type 2, Triglycerides: Elevated
Pharmacological Actions : Adiponectin upregulation, Hypoglycemic Agents, Hypolipidemic
[+]

Jujuboside A ameliorates cognitive deficiency in delirium.Jul 04, 2023

Pubmed Data : J Pharm Pharmacol. 2023 Jul 5 ;75(7):886-897. PMID: 37330271
Article Published Date : Jul 04, 2023
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Delirium, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Jujuboside A ameliorates tubulointerstitial fibrosis in diabetic mice.Aug 31, 2022

Pubmed Data : Chin J Nat Med. 2022 Sep ;20(9):656-668. PMID: 36162951
Article Published Date : Aug 31, 2022
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Diabetes Mellitus: Type 2, Diabetic Nephropathy
Pharmacological Actions : Renoprotective, Transforming growth factor beta (TGF-β) upregulation
[+]

Jujuboside B inhibits febrile seizure by modulating AMPA receptor activity.Mar 24, 2023

Pubmed Data : J Ethnopharmacol. 2023 Mar 25 ;304:116048. Epub 2022 Dec 19. PMID: 36549370
Article Published Date : Mar 24, 2023
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Febrile Seizures
Pharmacological Actions : Anticonvulsants
[+]

Jujuboside B post-treatment attenuates PM2.5-induced lung injury.Jul 18, 2022

Pubmed Data : Int J Environ Health Res. 2022 Jul 19:1-11. Epub 2022 Jul 19. PMID: 35854640
Article Published Date : Jul 18, 2022
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Air Pollution Linked Toxicity, Lung Damage
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents
[+]

Jujuboside B reverse chronic unpredictable mild stress-promoted tumor progression.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Immunol Res. 2022 ;2022:5211368. Epub 2022 Oct 8. PMID: 36254198
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative
[+]

Lactobacillus acidophilus-fermented jujube juice ameliorates chronic liver injury.Dec 26, 2023

Pubmed Data : Mol Nutr Food Res. 2023 Dec 27:e2300334. Epub 2023 Dec 27. PMID: 38150643
Article Published Date : Dec 26, 2023
Study Type : Animal Study
Additional Links
Substances : Fermented Foods and Beverages, Jujube, Lactobacillus Acidophilus
Diseases : Liver Damage, Liver Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Metagenomic analysis of gut microbiota modulatory effects of jujube polysaccharides in a colorectal cancer mouse model.Dec 11, 2019

Pubmed Data : Food Funct. 2019 Dec 12. Epub 2019 Dec 12. PMID: 31830158
Article Published Date : Dec 11, 2019
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Colorectal Cancer
Pharmacological Actions : Chemopreventive, Gastrointestinal Agents, Gastroprotective
Additional Keywords : Polysaccharides
[+]

Polysaccharides from Ziziphus jujube reversed hepatotoxicity in CCl4-intoxicated mice.Nov 30, 2014

Pubmed Data : Food Chem Toxicol. 2014 Dec ;74:76-84. Epub 2014 Sep 26. PMID: 25257694
Article Published Date : Nov 30, 2014
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective, NF-E2-Related Factor-2 (Nrf2) Modulator, Superoxide Dismutase Up-regulation
[+]

Potential antigenotoxicity assessment of Ziziphus jujuba fruit.Apr 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2019 May ;5(5):e01768. Epub 2019 May 18. PMID: 31193405
Article Published Date : Apr 30, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Jujube
Diseases : DNA damage
Pharmacological Actions : Antioxidants, Genoprotective
[+]

Protective effect of Zizyphus lotus jujube fruits against cypermethrin-induced oxidative stress and neurotoxicity.Feb 28, 2018

Pubmed Data : Biomarkers. 2018 Mar ;23(2):167-173. Epub 2017 Oct 20. PMID: 29017403
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Neurodegenerative Diseases, Oxidative Stress, Pesticide Toxicity
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Cypermethrin
[+]

The results of the present study showed that aqueous and ethyl acetate fractions of Ziziphus jujube prevented the development of hypertension.Apr 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Malays J Med Sci. 2020 May ;27(3):43-52. Epub 2020 Jun 30. PMID: 32684805
Article Published Date : Apr 30, 2020
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
[+]

The traditional Japanese herbal formula Saiko-Keishi-To controls pain in trigeminal neuralgia in rats. May 01, 2001

Pubmed Data : Masui. 2001 May;50(5):486-90. PMID: 11424461
Article Published Date : May 01, 2001
Study Type : Animal Study
Additional Links
Substances : Bupleurum, Chinese Skullcap , Cinnamon, Ginger, Japanese Herbal Formula: Sho-saiko-to, Jujube, Licorice, Peony, Pinellia
Diseases : Trigeminal Neuralgia
Pharmacological Actions : Analgesics
[+]

These results demonstrated that Jujuboside A exhibits an antiepileptogenic effect by alleviating oxidative stress and inflammatory responses.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:7792791. Epub 2022 Sep 9. PMID: 36118077
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Brain Injury: Traumatic, Epilepsy
Pharmacological Actions : Anti-Inflammatory Agents, Anticonvulsants, Antioxidants
[+]

Treatment with protopheophorbide A significantly inhibited the MDA-MB-231 tumor growth.Jan 10, 2018

Pubmed Data : Mol Carcinog. 2018 11 ;57(11):1507-1524. Epub 2018 Jul 18. PMID: 29978911
Article Published Date : Jan 10, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Jujube
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
Additional Keywords : Plant Extracts
[+]

Wild jujube polysaccharides protect against inflammatory bowel disease by enabling enhanced intestinal barrier function.Aug 04, 2015

Pubmed Data : Food Funct. 2015 Aug 5 ;6(8):2568-77. Epub 2015 Jun 26. PMID: 26114600
Article Published Date : Aug 04, 2015
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Gastroprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Wound healing and anti-inflammatory effects of a newly developed ointment containing jujube leaves extract.Nov 21, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Life (Basel). 2022 Nov 22 ;12(12). Epub 2022 Nov 22. PMID: 36556312
Article Published Date : Nov 21, 2022
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Wound Healing
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Z. jujuba fruit ethanolic extract possesses antidiarrhoeal and antibacterial activity in a dose depending manner.May 19, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Open Access Maced J Med Sci. 2018 May 20 ;6(5):757-766. Epub 2018 May 15. PMID: 29875842
Article Published Date : May 19, 2018
Study Type : Animal Study
Additional Links
Substances : Betulinic acid, Jujube
Diseases : Diarrhea
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Antidiarrheals
Additional Keywords : Dose Response
[+]

Z. jujuba root bark extracts could be a therapeutic agent for liver toxicity and chronic inflammation.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2016 ;7:298. Epub 2016 Sep 7. PMID: 27656145
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Jujube
Diseases : Chemically-Induced Liver Damage, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-10 downregulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ziziphus jujuba aqueous extract possesses an antiamnesic effect.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:6610864. Epub 2021 May 31. PMID: 34194520
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Alzheimer's Disease
Pharmacological Actions : Acetylcholinesterase Inhibitor, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ziziphus jujuba Mill seed ameliorates insomnia.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:653767. Epub 2021 Jun 16. PMID: 34220499
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Insomnia
Pharmacological Actions : Gastrointestinal Agents
[+]

Zizyphus jujuba and Jujuboside B may have a possible role in the treatment of asthma.Dec 31, 2018

Pubmed Data : Respir Physiol Neurobiol. 2019 02 ;260:28-36. Epub 2018 Dec 3. PMID: 30521862
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Asthma
Pharmacological Actions : Anti-Asthmatic Agents
Additional Keywords : Plant Extracts
[+]

Zizyphus lotus fruit improved glycaemia, lipids concentrations and inflammation in obese mice.May 31, 2019

Pubmed Data : Arch Physiol Biochem. 2019 Jun 1:1-8. Epub 2019 Jun 1. PMID: 31155964
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic
[+]

Zizyphus lotus L. fruit has a hepatoprotective effect against hepatic lesions induced by carbon tetrachloride.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:6161593. Epub 2019 Dec 25. PMID: 31949468
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective, Hypolipidemic
[+]

A review of edible jujube, the Ziziphus jujuba fruit: A heath food supplement for anemia prevalence.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:593655. Epub 2020 Nov 26. PMID: 33324222
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : Jujube
Diseases : Anemia
Pharmacological Actions : Immunomodulatory
[+]

An aqueous extract of the Ziziphus jujuba protects PC12 cells against high glucose-induced toxicity.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2015 Mar ;18(3):301-6. PMID: 25945244
Article Published Date : Feb 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Diabetic Neuropathy, Hyperglycemia
Pharmacological Actions : Anti-Apoptotic, Antioxidants
Additional Keywords : Plant Extracts
[+]

Anti-inflammatory and cytotoxic activities of constituents isolated from the fruits of Ziziphus jujuba var. inermis Rehder.Jul 04, 2019

Pubmed Data : Fitoterapia. 2019 Jul 5 ;137:104261. Epub 2019 Jul 5. PMID: 31284019
Article Published Date : Jul 04, 2019
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Cytotoxic, Nitric Oxide Inhibitor
[+]

Antitumor activity of jujube fruit extracts in KG-1 and NALM-6 acute leukemia cell lines.Sep 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Hematol Oncol Stem Cell Res. 2023 Oct 1 ;17(4):257-266. PMID: 38076779
Article Published Date : Sep 30, 2023
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Acute lymphoblastic leukemia (ALL)
[+]

Bioactive compounds, antioxidant and antimicrobial activities of extracts from different plant parts of two Ziziphus Mill. speciesDec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2020 ;15(5):e0232599. Epub 2020 May 19. PMID: 32428000
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Escherichia coli Infections, Listeria Infections, Salmonella Infections, Staphylococcus aureus infection
Pharmacological Actions : Antimicrobial, Antioxidants
[+]

Cytoprotective effects of the aqueous extract of the Ziziphus jujuba fruit on TBHP-induced damage on human fibroblast cells.Nov 21, 2019

Pubmed Data : J Basic Clin Physiol Pharmacol. 2019 Nov 22. Epub 2019 Nov 22. PMID: 31756163
Article Published Date : Nov 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Cytoprotective
Additional Keywords : Dose Response, Plant Extracts
[+]

Extracts of Jujube seeds contained alkaloids and reducing sugars, and induced caspase-dependent apoptosis in human Jurkat leukemia T cells.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Chin Med. 2016 ;11:15. Epub 2016 Apr 1. PMID: 27042202
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Plant Extracts
[+]

Flavonoids-rich Ziziphus jujuba extract can inhibit biofilm formation.Jun 16, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2020 Jun 17 ;20(1):187. Epub 2020 Jun 17. PMID: 32552790
Article Published Date : Jun 16, 2020
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Jujube
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation
[+]

Hepatoprotective functions of jujuboside B.Dec 31, 2022

Pubmed Data : J Nat Med. 2023 Jan ;77(1):87-95. Epub 2022 Sep 6. PMID: 36064835
Article Published Date : Dec 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Jujuba fruit extract may be suitable for treatment of infectious diseases, particularly for Pediatric infection.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Ped Hematol Oncol. 2013 ;3(1):216-21. Epub 2013 Jan 22. PMID: 24575267
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Aspergillosis, Candida Albicans, Escherichia coli Infections, Staphylococcus aureus infection
Pharmacological Actions : Antifungal Agents, Antimicrobial
Additional Keywords : Plant Extracts
[+]

Jujube and green tea could be useful to attenuate solar UVB light-induced oxidative stress and skin photoaging.Apr 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2020 May-Jun;10(3):287-296. PMID: 32523883
Article Published Date : Apr 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Green Tea, Jujube
Diseases : Photooxidative Stress, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Antioxidants, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Photoprotective
[+]

Jujube honey induces apoptosis in human hepatocellular carcinoma HepG2 cell.Jul 31, 2019

Pubmed Data : J Food Biochem. 2019 Aug 1:e12998. Epub 2019 Aug 1. PMID: 31373040
Article Published Date : Jul 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Honey, Jujube
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
[+]

Jujuboside A attenuates sepsis-induced cardiomyopathy.May 14, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Pharmacol. 2023 May 15 ;947:175451. Epub 2022 Dec 8. PMID: 36502962
Article Published Date : May 14, 2023
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Cardiomyopathy, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cardioprotective
[+]

Jujuboside B suppresses angiogenesis and tumor growth.May 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2023 Jun ;9(6):e17072. Epub 2023 Jun 7. PMID: 37484305
Article Published Date : May 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Cancers: All
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Vascular Endothelial Growth Factor Regulator
[+]

Protective effects of Jujubosides on 6-OHDA-induced neurotoxicity.Jun 25, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2022 Jun 26 ;27(13). Epub 2022 Jun 26. PMID: 35807356
Article Published Date : Jun 25, 2022
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
[+]

Quantitative analysis of biochemical characteristics and anti-cancer properties in MCF-7 breast cancer cell line.Feb 23, 2024

Pubmed Data : Mol Biol Rep. 2024 Feb 24 ;51(1):344. Epub 2024 Feb 24. PMID: 38400882
Article Published Date : Feb 23, 2024
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive
[+]

The hypoglycemic activities and underlying mechanisms of two saponins-rich components from fried Ziziphus jujuba.Mar 18, 2023

Pubmed Data : Mol Nutr Food Res. 2023 Mar 19:e2200364. Epub 2023 Mar 19. PMID: 36934422
Article Published Date : Mar 18, 2023
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Hyperglycemia
Pharmacological Actions : Hypoglycemic Agents
[+]

The standardized extract of jujube fruit regulates pro-inflammatory cytokine expression in cultured murine macrophages.Sep 30, 2014

Pubmed Data : Phytother Res. 2014 Oct ;28(10):1527-32. Epub 2014 May 8. PMID: 24806434
Article Published Date : Sep 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Therapeutic effects of Ziziphus jujuba Mill. fruit in traditional and modern medicine: a review.Oct 30, 2019

Pubmed Data : Med Chem. 2019 Oct 31. Epub 2019 Oct 31. PMID: 31670624
Article Published Date : Oct 30, 2019
Study Type : Review
Additional Links
Substances : Jujube
Diseases : Cardiovascular Diseases, Hypertension, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Antihypertensive Agents, Cardioprotective, Hypolipidemic
[+]

Three acidic polysaccharides derived from sour jujube seeds protect intestinal epithelial barrier function in LPS induced Caco-2 cell inflammation.Jun 14, 2023

Pubmed Data : Int J Biol Macromol. 2023 Jun 15 ;240:124435. Epub 2023 Apr 14. PMID: 37062376
Article Published Date : Jun 14, 2023
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Inflammation, Inflammatory Bowel Diseases, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Polysaccharides
[+]

Triterpenoids from Ziziphus jujuba induce apoptotic cell death in human cancer cells through mitochondrial reactive oxygen species production.Jul 16, 2018

Pubmed Data : Food Funct. 2018 Jul 17 ;9(7):3895-3905. PMID: 29968885
Article Published Date : Jul 16, 2018
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Breast Cancer: Triple Negative , Lung Cancer, Prostate Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Plant Extracts
[+]

Unique triterpenoid of jujube root protects cisplatin-induced damage in kidney epithelial LLC-PK1 cells.Mar 01, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Mar 2 ;12(3). Epub 2020 Mar 2. PMID: 32131519
Article Published Date : Mar 01, 2020
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents, Renoprotective
[+]

Wild Jujube: A review of its phytonutrients, health benefits, metabolism, and applications.Jun 21, 2022

Pubmed Data : J Agric Food Chem. 2022 Jun 22. Epub 2022 Jun 22. PMID: 35731918
Article Published Date : Jun 21, 2022
Study Type : Review
Additional Links
Substances : Jujube
Diseases : Central Nervous System Diseases, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Z. jujuba could protect against cisplatin-induced kidney epithelial cell death. Jan 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2021 10 31 ;11(11). Epub 2021 Oct 31. PMID: 34827612
Article Published Date : Jan 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation, Renoprotective
[+]

Ziziphus jujuba fruit has promising anticancer activities in vitro and in vevo. Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Rev. 2015 Jul-Dec;9(18):99-106. PMID: 26392706
Article Published Date : Jun 30, 2015
Study Type : Review
Additional Links
Substances : Jujube
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic
Additional Keywords : Chemoresistance
[+]

Ziziphus jujuba Mill. leaf extract restrains adipogenesis.Jul 17, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2021 Jul 18 ;141:111934. Epub 2021 Jul 18. PMID: 34323694
Article Published Date : Jul 17, 2021
Study Type : In Vitro Study
Additional Links
Substances : Jujube
Diseases : Obesity
Pharmacological Actions : Anti-Adipogenic
Additional Keywords : Anti-Obesity Agents

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