Kaempferol

Name	AC	CK
Oxidative Stress	4	17
Inflammation	4	7
Breast Cancer	5	5
DNA damage	1	5
Breast Cancer: Triple Negative	2	3
Influenza A	2	3
Asthma	1	2
Autoimmune Diseases	1	2
Bacterial Infections: Resistance/Biofilm Formation	2	2
Bone Fractures	1	2
Burns	1	2
Cancers: All	2	2
Carcinoma: Small Cell Lung	1	2
Cardiovascular Diseases	1	2
Cholesterol: Oxidation	2	2
Diabetes	1	2
Diabetes Mellitus: Type 1	1	2
Diabetes Mellitus: Type 2	1	2
Diabetic Complications	1	2
Diabetic Neuropathy	1	2
Esophageal Cancer	2	2
Excitotoxicity	1	2
Immune Dysregulation: TH1/TH2 imbalance	1	2
Ischemia: Myocardial	1	2
Kidney Cancer	1	2
Klebsiella Infections	1	2
Leukemia: Acute promyelocytic leukemia	2	2
Liver Cancer	2	2
Lung Injury: Acute	1	2
MRSA	2	2
Melanoma	1	2
Neurodegenerative Diseases	1	2
Obesity	2	2
Osteoarthritis	1	2
Osteosarcoma	1	2
Pancreatic Cancer	2	2
Periodontitis	1	2
Radiation	1	2
Rheumatoid Arthritis	1	2
Sepsis	1	2
Staphylococcus aureus infection	2	2
Wound Healing	1	2
Wound Healing: Delayed	1	2
Advanced Glycation End products (AGE)	1	1
Alcohol Toxicity	1	1
Bisphenol Toxicity	1	1
Brain Cancer	1	1
Cancer Metastasis	1	1
Cancers: Multi-Drug Resistant	1	1
Cytomegalovirus Infections	1	1
Degenerative Disk Disease	1	1
Glioblastoma	1	1
H1N1 Infection	1	1
Human Influenza	1	1
Hyperinsulinism	1	1
Influenza	1	1
Intestinal Permeability	1	1
Leukemia	1	1
Lung Cancer	1	1
Non-Small-Cell Lung Carcinoma	1	1
Ovarian Cancer	1	1
Pancreatic Cancer: Metastatic	1	1
Weight Problems	1	1

Name	AC	CK
Antioxidants	9	24
Apoptotic	14	16
Anti-Inflammatory Agents	9	14
Neuroprotective Agents	3	14
Anti-Apoptotic	3	13
Anti-metastatic	6	12
Antiproliferative	10	11
Interleukin-6 Downregulation	6	10
Tumor Necrosis Factor (TNF) Alpha Inhibitor	6	10
Chemopreventive	3	7
Interleukin-1 beta downregulation	4	7
NF-kappaB Inhibitor	4	7
Cell cycle arrest	6	6
Antimutagenic Agents	1	5
Anti-Bacterial Agents	4	4
Hypoglycemic Agents	2	3
MicroRNA modulator	2	3
Antineoplastic Agents	1	2
Antinoceceptive	1	2
Antiviral Agents	2	2
Cardioprotective	1	2
Chemotherapeutic	2	2
Cyclooxygenase 2 Inhibitors	1	2
Enzyme Inhibitors	1	2
Excitatory Amino Acid Agonists	1	2
Interleukin-10 upregulation	2	2
Malondialdehyde Down-regulation	1	2
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	2
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	2
Matrix metalloproteinase-8 (MMP-8) inhibitor	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	2
Osteoprotective	1	2
Postaglandin PGE2 downregulation	1	2
Radioprotective	1	2
Radiosensitizer	1	2
STAT3 Inhibitor	1	2
Autophagy Up-regulation	1	1
Bcl-2 protein down-regulation	1	1
Chemosensitizer	1	1
Cytoprotective	1	1
Cytotoxicity	1	1
Drug synergy	1	1
Epidermal growth factor receptor (EGFR) inhibitor	1	1
Estrogen Receptor Modulators	1	1
Multidrug Resistance Gene Modulators	1	1
Neurominidase Inhibitor	1	1
Nrf2 activation	1	1
Phase II Detoxification Enzyme Inducer	1	1
Tumor Suppressor Protein p53 Upregulation	1	1

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Flavonol intake and cognitive decline in middle-aged adults.Nov 30, 2015

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Pubmed Data : J Med Food. 2015 Dec ;18(12):1327-32. Epub 2015 Sep 1. PMID: 26325006

Article Published Date : Nov 30, 2015

Study Type : Human Study

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Substances : Flavonoids, Kaempferol, Myricetin, Quercetin

Diseases : Aging: Brain , Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Phytotherapy, Plant Extracts

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Sea buckthorn leaf extracts protect neuronal PC-12 cells from oxidative stress.Jul 27, 2017

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Pubmed Data : ACS Omega. 2021 Jun 15 ;6(23):15046-15056. Epub 2021 May 29. PMID: 34151085

Article Published Date : Jun 14, 2021

Study Type : Animal Study

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Substances : Flavonoids, Kaempferol

Diseases : Drug-Induced Toxicity: Indomethacin

Pharmacological Actions : Gastroprotective

Problem Substances : Indomethacin

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Kaempferol addition increases the antimalarial activity of artesunate.Dec 31, 2019

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Pubmed Data : J Trop Med. 2020 ;2020:6165928. Epub 2020 Jun 29. PMID: 32684939

Article Published Date : Dec 31, 2019

Study Type : Animal Study

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Substances : Artesunate, Kaempferol

Diseases : Malaria

Pharmacological Actions : Antimalarials

Additional Keywords : Natural Substance Synergy

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Kaempferol alleviates acute alcoholic liver injury in mice.Nov 26, 2019

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Kaempferol downregulates TH2 cytokine production without inducing a TH1 pattern of inflammation in a manner that may have potential clinical use for the treatment of allergic asthma. Sep 12, 2009

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Pubmed Data : Int Immunopharmacol. 2009 Sep 12. PMID: 19755174

Article Published Date : Sep 12, 2009

Study Type : Animal Study

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Substances : Kaempferol

Diseases : Asthma, Immune Dysregulation: TH1/TH2 imbalance

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Kaempferol may have a therapeutic role in preventing and/or treating autoimmune diseases. Sep 15, 2007

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Pubmed Data : J Immunol. 2007 Sep 15;179(6):3881-7. PMID: 17785825

Article Published Date : Sep 15, 2007

Study Type : Animal Study

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Substances : Kaempferol

Diseases : Autoimmune Diseases

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Kaempferol may prove to be a novel agent for the treatment of liver fibrosis or other fibroproliferative diseases.Jul 04, 2019

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Pubmed Data : Adv Pharmacol Pharm Sci. 2023 ;2023:1387665. Epub 2023 Feb 27. PMID: 36891541

Article Published Date : Dec 31, 2022

Study Type : Review

Additional Links

Substances : Kaempferol

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage, Liver Disease

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen

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Anti-inflammatory and anti-allergic potential of dietary flavonoids: A review.Nov 30, 2022

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Pubmed Data : Biomed Res Int. 2020 ;2020:5891016. Epub 2020 Oct 21. PMID: 33145355

In silico targeting SARS-CoV-2 spike protein and main protease by biochemical compounds.Sep 21, 2021

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Pubmed Data : Endocrine. 2018 04 ;60(1):83-94. Epub 2018 Feb 1. PMID: 29392616

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

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Substances : Kaempferol

Diseases : Cardiomyopathy, Hyperglycemia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, NF-kappaB Inhibitor, Nrf2 activation

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Kaempferol blocks neutrophil extracellular traps formation and reduces tumour metastasis.May 18, 2020

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Pubmed Data : J Cell Mol Med. 2020 May 19. Epub 2020 May 19. PMID: 32427405

Article Published Date : May 18, 2020

Study Type : In Vitro Study

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Substances : Kaempferol

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic

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Kaempferol can reverse the 5-Fu resistance of colorectal cancer cells.Mar 23, 2022

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Pubmed Data : Int J Mol Sci. 2022 Mar 24 ;23(7). Epub 2022 Mar 24. PMID: 35408903

Article Published Date : Mar 23, 2022

Study Type : In Vitro Study

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Substances : Kaempferol

Diseases : Cancers: Drug Resistant, Colon Cancer, Colorectal Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil

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Kaempferol combined with ABT-199 has a potential application prospect in the treatment of hepatocellular carcinoma.Dec 31, 2021

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Pubmed Data : J BUON. 2019 Jul-Aug;24(4):1555-1561. PMID: 31646808

Article Published Date : Jun 30, 2019

Study Type : In Vitro Study

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Substances : Kaempferol

Diseases : Endometrial Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Selective Cytotoxicity

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Kaempferol has protective effects on ethanol-induced mouse primary hepatocytes injury.Jul 04, 2018

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Pubmed Data : Am J Chin Med. 2018 Jul 5:1-18. Epub 2018 Jul 5. PMID: 29976085

Article Published Date : Jul 04, 2018

Study Type : In Vitro Study

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Substances : Kaempferol

Diseases : Alcohol Toxicity

Pharmacological Actions : Cytoprotective

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Kaempferol impairs aerobic glycolysis against melanoma metastasis.Sep 14, 2022

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Pubmed Data : Eur J Pharmacol. 2022 Sep 15 ;931:175226. Epub 2022 Aug 22. PMID: 36007607

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Pubmed Data : Phytomedicine. 2023 Sep ;118:154942. Epub 2023 Jun 23. PMID: 37421767

Article Published Date : Aug 31, 2023

Study Type : In Vitro Study

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Substances : Kaempferol

Diseases : Coronavirus Disease

Pharmacological Actions : Antiviral Agents

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Kaempferol inhibits the primary attachment phase of biofilm formation in Staphylococcus aureus.Dec 31, 2016

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Pubmed Data : J Physiol Biochem. 2016 Mar 21. Epub 2016 Mar 21. PMID: 27000882

Article Published Date : Mar 20, 2016

Study Type : In Vitro Study

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Substances : Kaempferol

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Kaempferol may serve as a novel target for treatment of Intervertebral disc degeneration.Dec 29, 2016

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Pubmed Data : Int Immunopharmacol. 2016 Dec 30 ;43:236-242. Epub 2016 Dec 30. PMID: 28043032

Article Published Date : Dec 29, 2016

Study Type : In Vitro Study

Additional Links

Substances : Kaempferol

Diseases : Degenerative Disk Disease

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-6 Downregulation

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Kaempferol might improve bleomycin-induced fibrosis by reducing oxidative stress, inflammation, and oxidative cellular damage.Sep 30, 2019

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Pubmed Data : Neurochem Res. 2019 Nov 25. Epub 2019 Nov 25. PMID: 31768814

Article Published Date : Nov 24, 2019

Study Type : In Vitro Study

Additional Links

Substances : Kaempferol

Diseases : Cadmium Poisoning

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

Problem Substances : Cadmium

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Kaempferol protects blood vessels from damage induced by oxidative stress and inflammation.Dec 31, 2019

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Kaempferol suppresses human gastric cancer SNU-216 cell proliferation and promotes cell autophagy.Feb 13, 2019

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Targeting SARS-CoV-2 spike protein of COVID-19 with naturally occurring phytochemicals.Jul 21, 2020

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Pubmed Data : J Biomol Struct Dyn. 2020 Jul 22:1-11. Epub 2020 Jul 22. PMID: 32698689

Article Published Date : Jul 21, 2020

Study Type : In Vitro Study

Additional Links

Substances : Fisetin, Kaempferol, Quercetin

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

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Tart cherry extract inhibits the mitochondrial apoptotic cell death elicited by airborne PM 10 in human epidermal keratinocytes.Mar 12, 2021

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Pubmed Data : Biomed Pharmacother. 2019 Sep ;117:109086. Epub 2019 Jun 11. PMID: 31200254

Article Published Date : Aug 31, 2019

Study Type : Review

Additional Links

Substances : Kaempferol

Diseases : Breast Cancer

Pharmacological Actions : Chemopreventive, Chemotherapeutic

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The ORF3a viroporin of SARS-CoV-2 may indeed be a promising target for antiviral substances.Mar 31, 2023

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Pubmed Data : Sci Rep. 2023 Apr 1 ;13(1):5328. Epub 2023 Apr 1. PMID: 37005439

Article Published Date : Mar 31, 2023

Study Type : In Vitro Study

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Substances : EGCG (Epigallocatechin gallate), Flavonoids, Kaempferol, Nobiletin , Quercetin

Diseases : Coronavirus Disease

Pharmacological Actions : Antiviral Agents

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View the Evidence: 194 Abstracts with Kaempferol Research

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Flavonol intake and cognitive decline in middle-aged adults.Nov 30, 2015

Sea buckthorn leaf extracts protect neuronal PC-12 cells from oxidative stress.Jul 27, 2017

An aqueous horseradish extract and its main flavonoids, kaempferol and quercetin has great potential to protect DNA from damage. Dec 31, 2013

Preparation, characterization, and evaluation of the antitumor effect of kaempferol nanosuspensions.May 05, 2023

A enriched Mongolian oak cups extract could exert anti-diabetic effects through alleviating types 1 and 2 diabetes and their complications.Apr 29, 2018

Activity of compounds from temperate propolis against Trypanosoma brucei and Leishmania mexicana Jun 25, 2021

Ameliorative effect of kaempferol, a flavonoid, on oxidative stress in streptozotocin-induced diabetic rats.Aug 31, 2015

Antiviral efficacy of flavonoids against enterovirus 71 infection.Jul 06, 2019

Dietary flavonoid kaempferol inhibits glucocorticoid-induced bone loss by promoting osteoblast survival.Feb 12, 2018

Dietary intake of kaempferol ameliorated hyperglycemia and improved insulin levels in middle-aged obese diabetic mice.Dec 31, 2014

Dietary kaempferol suppresses inflammation of dextran sulfate sodium-induced colitis.Jan 31, 2012

E. sativa might be beneficial in chronic diabetes in ameliorating the progression of diabetic neuropathy.Jul 31, 2018

Evaluation of inhibitory effects of flavonoids on breast cancer resistance protein.Sep 04, 2019

Galangin and kaempferol alleviate the indomethacin-caused cytotoxicity and barrier loss in rat intestinal epithelial cells.Jun 14, 2021

Kaempferol addition increases the antimalarial activity of artesunate.Dec 31, 2019

Kaempferol alleviates acute alcoholic liver injury in mice.Nov 26, 2019

Kaempferol alleviates insulin resistance via hepatic IKK/NF-κB signal in type 2 diabetic rats.Aug 31, 2015

Kaempferol alleviates murine experimental colitis.Dec 31, 2020

Kaempferol ameliorates H9N2 swine influenza virus-induced acute lung injury.Apr 30, 2017

Kaempferol ameliorates pulmonary vascular remodeling in chronic hypoxia-induced pulmonary hypertension.Apr 30, 2023

Kaempferol ameliorates symptoms of metabolic syndrome.Jul 18, 2021

Kaempferol and Catechin produced a concentration dependent anti-fibrillogenic effects.Jul 28, 2015

Kaempferol and chrysin have synergistic effects to improve septic mice survival.Jan 05, 2017

Kaempferol appears to be an effective topical wound healing agent in the treatment of both nondiabetic and diabetic wounds.Dec 31, 2018

Kaempferol attenuated diabetic nephropathy by reducing apoptosis and promoting autophagy through AMPK/mTOR pathways.Dec 31, 2021

Kaempferol attenuated myocardial ischemia-reperfusion injury in diabetic ratsMay 14, 2017

Kaempferol attenuates doxorubicin-induced renal tubular injury.Dec 31, 2022

Kaempferol attenuates imiquimod-induced psoriatic skin inflammation in a mouse model.Aug 12, 2019

Kaempferol attenuates neuroinflammation and blood brain barrier dysfunction to improve neurological deficits in cerebral ischemia/reperfusion.Jul 31, 2019

Kaempferol attenuates nonalcoholic fatty liver disease in type 2 diabetes.Aug 31, 2023

Kaempferol attenuates streptozotocin-induced diabetic nephropathy.Nov 01, 2020

Kaempferol can safely inhibit the metastasis of the 786-O RCC cells into the lungs by about 87.4%.Dec 31, 2016

Kaempferol downregulates TH2 cytokine production without inducing a TH1 pattern of inflammation in a manner that may have potential clinical use for the treatment of allergic asthma. Sep 12, 2009

Kaempferol exhibits anti-pyroptosis activities.Sep 30, 2019

Kaempferol has the potential to restore deranged activity of membrane-bound ATPases in STZ-induced diabetic rats.Apr 07, 2015

Kaempferol has therapeutic value in thermal burn-induced skin injuries.Jan 01, 2010

Kaempferol improves acute kidney injury via inhibition of macrophage infiltration in septic mice.Jul 25, 2023

Kaempferol increased tumor cell killing by radiation in vitro and in vivo through inhibition of the AKT/PI3K and ERK pathways and activation of the mitochondria apoptosis pathwayAug 18, 2015

Kaempferol induces programmed cell death in human osteosarcoma cells.Nov 01, 2010

Kaempferol inhibits the migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes.Dec 17, 2017

Kaempferol inhibits the progression of silica-induced pulmonary fibrosis.Sep 26, 2019

Kaempferol may be useful in decreasing alveolar bone resorption, attachment loss and MMP-1 and -8 production in experimental periodontitis.Mar 31, 2016

Kaempferol may have a therapeutic role in preventing and/or treating autoimmune diseases. Sep 15, 2007

Kaempferol may prove to be a novel agent for the treatment of liver fibrosis or other fibroproliferative diseases.Jul 04, 2019

Kaempferol might act as a therapeutic potential candidate for cancer metastasis.Jan 31, 2015

Kaempferol might be a novel promising therapeutic agent for spinal cord injury.Apr 02, 2021

Kaempferol promotes bone formation in part via the mTOR signaling pathway.Nov 30, 2019

Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro.Feb 05, 2012

Kaempferol protects against gamma radiation-induced mortality and damage.Apr 19, 2018

Kaempferol protects against retinal photoreceptor degeneration in a mouse model of light-induced retinal injury.Dec 13, 2022

Kaempferol stimulates WNT/β-catenin signaling pathway to induce differentiation of osteoblasts.Aug 30, 2019

kaempferol-3-O-glucorhamnosidein a potent anti-inflammatory in vitro and in vivo.Dec 06, 2018

Kaempferol-3-O-glucuronide ameliorates non-alcoholic steatohepatitis.May 13, 2021

Oral administration of apigenin significantly reduced elevated levels of SASP and IκBζ mRNA in the kidneys of aged rats.Jun 16, 2015

Oral administration of kaempferol inhibits bone loss in rat model of ovariectomy-induced osteopenia.Sep 30, 2017

Polyphenols can be promising in combating diabetic neuropathy-associated damaging pathways.Dec 31, 2020

Protective effects of kaempferol on lipopolysaccharide-induced mastitis in mice.Sep 30, 2014

Quercetin, kaempferol and biapigenin from St. John's wort are neuroprotective against excitotoxicity. May 01, 2008

Rebalancing of the gut flora and microbial metabolism is responsible for the anti-arthritis effect of kaempferol.Aug 18, 2019

Tea seed kaempferol triglycoside attenuates LPS-induced systemic inflammation and ameliorates cognitive impairments.Mar 21, 2022

The concomitant reduction in COX-2 expression in paw tissues suggested kaempferol's role in mitigation of inflammation by targeting STAT3 and NF-κB.Nov 30, 2017

The obtained data provide evidences that kaempferol pre-treatment has the protective effect to preserve the cortical tissues in cadmium-exposed rats.Nov 02, 2020

The osteoprotective effects of kaempferol.Dec 31, 2018

Therapeutic role of kaempferol and myricetin in streptozotocin-induced diabetes.Dec 29, 2022

These findings demonstrated that Moringa oleifera seed ethanol extractscould improve sleep by regulating GABAA-ergic systems.Nov 30, 2022

These findings show the hepatoprotective properties of kaempferol against alcohol-induced liver injury.Dec 31, 2014

These results suggest that kaempferol had significant anti-inflammatory and anti-arthritis effects.Aug 13, 2017

Antiproliferative mechanisms of a polyphenolic combination of kaempferol and fisetin in triple-negative breast cancer cells.Mar 28, 2023

A comparative study of anti-leukemic effects of kaempferol and epigallocatechin-3-gallate (EGCG) on human leukemia HL-60 cells.Jun 30, 2021

A review of kaempferol, myricetin and fisetin in prostate and bladder cancer.Oct 22, 2021

A review of natural products, their effects on SARS-CoV-2 and their utility as lead compounds in the discovery of drugs for the treatment of COVID-19.Dec 01, 2021

A review of the hepatoprotective effect of kaempferol.Dec 31, 2022

Kaempferol

View the Evidence:
194 Abstracts with Kaempferol Research