Kava Kava

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25 Diseases Researched for Kava Kava
NameACCKFocus
Anxiety Disorders15177Locked
Depression230Locked
Generalized Anxiety Disorder120Locked
Insomnia212Locked
Cancers: All211Locked
Cognitive Decline/Dysfunction110Locked
Mood Disorders110Locked
Perimenopausal Syndrome110Locked
Stress110Locked
Benzo[a]pyrene-induced Toxicity 24Locked
Lung Cancer24Locked
Phobia: Social13Locked
Phobias13Locked
Bladder Cancer22Locked
Inflammation22Locked
Alzheimer's Disease11Locked
Asthma11Locked
Cancers: Drug Resistant11Locked
Cocaine Withdrawal11Locked
Multiple Sclerosis11Locked
Neurodegenerative Diseases11Locked
Oxidative Stress11Locked
Prostate Cancer11Locked
Tobacco Addiction/Withdrawal11Locked
Urinary Tract Infections11Locked
16 Pharmacological Actions Researched for Kava Kava
NameACCKFocus
Anxiolytic774Locked
Antidepressive Agents110Locked
Antiproliferative 35Locked
Apoptotic34Locked
Chemopreventive24Locked
Antineoplastic Agents23Locked
Anti-Inflammatory Agents22Locked
Hypnotics and Sedatives12Locked
Neuroprotective Agents22Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor22Locked
Antioxidants11Locked
Cell cycle arrest11Locked
Cyclooxygenase 1 Inhibitor11Locked
Cyclooxygenase 2 Inhibitors11Locked
Endocannabinoid Modulator11Locked
NF-kappaB Inhibitor11Locked

View the Evidence:
42 Abstracts with Kava Kava Research

[+]

Ginkgo biloba, chamomile and kava kava exhibit therapeutic potential in generalizaed anxiety disorder.Oct 15, 2010

Pubmed Data : Rev Bras Psiquiatr. 2010 Oct 15. Epub 2010 Oct 15. PMID: 20963375
Article Published Date : Oct 15, 2010
Study Type : Meta Analysis
Additional Links
Substances : Chamomile, Ginkgo biloba, Kava Kava
Diseases : Generalized Anxiety Disorder
Additional Keywords : Benzodiazepine Alternatives, Benzodiazepine Receptor Agonist, Natural Substances Versus Drugs, Superiority of Natural Substances versus Drugs
[+]

Kava is an effective treatment alternative to pharmaceuticals in non-psychotic anxiety disorders.Mar 01, 2005

Pubmed Data : Phytother Res. 2005 Mar;19(3):183-8. PMID: 15934028
Article Published Date : Mar 01, 2005
Study Type : Meta Analysis
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders, Depression
Additional Keywords : Plant Extracts
[+]

Kava Kava appears to be a short-term treatment for anxiety, but not a replacement for prolonged anti-anxiety use. Oct 31, 2018

Pubmed Data : Complement Ther Clin Pract. 2018 Nov ;33:107-117. Epub 2018 Sep 15. PMID: 30396607
Article Published Date : Oct 31, 2018
Study Type : Meta Analysis, Review
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
Additional Keywords : Plant Extracts
[+]

Meta-Analysis: Kava extract is superior to placebo as a symptomatic treatment for anxiety.Feb 01, 2000

Pubmed Data : J Clin Psychopharmacol. 2000 Feb;20(1):84-9. PMID: 10653213
Article Published Date : Feb 01, 2000
Study Type : Meta Analysis
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders
Additional Keywords : Plant Extracts
[+]

Meta-Analysis: Kava is safe and superior to a placebo for treating anxiety. Jan 01, 2002

Pubmed Data : Cochrane Database Syst Rev. 2002(2):CD003383. PMID: 12076477
Article Published Date : Jan 01, 2002
Study Type : Meta Analysis
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders
Additional Keywords : Plant Extracts
[+]

The current weight of evidence supports the use of kava in treatment of anxiety with a significant result occurring in four out of six studies reviewed.Jan 01, 2011

Pubmed Data : Aust N Z J Psychiatry. 2011 Jan;45(1):27-35. Epub 2010 Nov 15. PMID: 21073405
Article Published Date : Jan 01, 2011
Study Type : Meta Analysis
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
[+]

Kava and valerian root are effective in the treatment of stress-induced insomnia. Sep 01, 2001

Pubmed Data : Phytother Res. 2001 Sep;15(6):549-51. PMID: 11536390
Article Published Date : Sep 01, 2001
Study Type : Human Study
Additional Links
Substances : Kava Kava, Valerian
Diseases : Insomnia, Stress
[+]

Kava appears safe and effective for anxiety disorders. Jun 01, 2009

Pubmed Data : Complement Ther Med. 2009 Jun;17(3):176-8. Epub 2009 Feb 7. PMID: 19398072
Article Published Date : Jun 01, 2009
Study Type : Human Study
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders
[+]

Kava enhances cognitive performance and cheerful mood.Jun 01, 2004

Pubmed Data : Hum Psychopharmacol. 2004 Jun;19(4):243-50. PMID: 15181652
Article Published Date : Jun 01, 2004
Study Type : Human Study
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders, Cognitive Decline/Dysfunction, Mood Disorders
Additional Keywords : Plant Extracts, Superio+
[+]

Kava is effective in treating perioperative anxiety. Jan 01, 2000

Pubmed Data : Zentralbl Gynakol. 2000;122(11):561-5. PMID: 11127769
Article Published Date : Jan 01, 2000
Study Type : Human Study
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders
Additional Keywords : Plant Extracts
[+]

Kava is safe and effective in treating anxiety disorders and depression.Aug 01, 2009

Pubmed Data : Psychopharmacology (Berl). 2009 Aug;205(3):399-407. Epub 2009 May 9. PMID: 19430766
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders, Depression
Pharmacological Actions : Antidepressive Agents, Anxiolytic
Additional Keywords : Plant Extracts
[+]

Kava was judged to be an effective and safe treatment of non-psychotic anxiety syndrome.Apr 01, 2004

Pubmed Data : Phytother Res. 2004 Apr;18(4):297-300. PMID: 15162364
Article Published Date : Apr 01, 2004
Study Type : Human Study
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
[+]

Kava was judged to be well-tolerated and as effective as Buspirone and Opipramol in the acute treatment of out-patients suffering from Generalized Anxiety Disorder.Jan 01, 2003

Pubmed Data : Phytomedicine. 2003;10 Suppl 4:38-49. PMID: 12807341
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Kava was judged to improve the mood, particularly by reducing anxiety in perimenopausal women.Dec 01, 2008

Pubmed Data : Integr Cancer Ther. 2008 Dec;7(4):295-310. PMID: 12590005
Article Published Date : Dec 01, 2008
Study Type : Human Study
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders, Perimenopausal Syndrome
Pharmacological Actions : Anxiolytic
[+]

Safety Study: No evidence for irreversible liver damage has been found in kava users.Jan 01, 2003

Pubmed Data : J Toxicol Clin Toxicol. 2003;41(6):821-9. PMID: 14677792
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Substances : Kava Kava
Additional Keywords : Plant Extracts
[+]

There is a close inverse relationship between cancer incidence and kava consumption.Nov 01, 2000

Pubmed Data : Hawaii Med J. 2000 Nov;59(11):420-2. PMID: 11149250
Article Published Date : Nov 01, 2000
Study Type : Human Study
Additional Links
Substances : Kava Kava
Diseases : Cancers: All
[+]

Case study: Kava is effective in the treatment of anxiety disorder, simple phobia and specific social phobia. Nov 01, 2001

Pubmed Data : Phytother Res. 2001 Nov;15(7):646-7. PMID: 11746854
Article Published Date : Nov 01, 2001
Study Type : Human: Case Report
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders, Phobia: Social, Phobias
Additional Keywords : Plant Extracts
[+]

Kava compares favorably with diazepam in reducing anxiety in mice. Jun 01, 2002

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2002 Jun;26(5):855-60. PMID: 12369257
Article Published Date : Jun 01, 2002
Study Type : Animal Study
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
Additional Keywords : Benzodiazepine Alternatives, Plant Extracts, Superiority of Natural Substances versus Drugs
[+]

Kava exhibits anxiolytic properties in mice.Oct 01, 2003

Pubmed Data : Psychopharmacology (Berl). 2003 Oct;170(1):33-41. Epub 2003 Jul 4. PMID: 12845414
Article Published Date : Oct 01, 2003
Study Type : Animal Study
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
Additional Keywords : Plant Extracts
[+]

Kava exhibits chemopreventive properties in chemically-induced lung cancer.Nov 01, 2008

Pubmed Data : Cancer Prev Res (Phila). 2008 Nov;1(6):430-8. PMID: 19138990
Article Published Date : Nov 01, 2008
Study Type : Animal Study
Additional Links
Substances : Kava Kava
Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemopreventive
Additional Keywords : Plant Extracts
[+]

Kava kava improves sleep quality in sleep-disturbed rats.Jul 01, 2005

Pubmed Data : Psychopharmacology (Berl). 2005 Jul;180(3):564-9. Epub 2005 Feb 8. PMID: 15700178
Article Published Date : Jul 01, 2005
Study Type : Animal Study
Additional Links
Substances : Kava Kava
Diseases : Insomnia
Pharmacological Actions : Hypnotics and Sedatives
Additional Keywords : Plant Extracts
[+]

Safety Study: Aqueous kava extracts do not affect liver function tests in rats.Jun 01, 2003

Pubmed Data : Planta Med. 2003 Jun;69(6):496-9. PMID: 12865965
Article Published Date : Jun 01, 2003
Study Type : Animal Study
Additional Links
Substances : Kava Kava
Additional Keywords : Plant Extracts
[+]

Safety Study: chronic ethanolic kava extract is safe in rats.Sep 01, 2006

Pubmed Data : Phytomedicine. 2006 Sep;13(8):542-9. Epub 2006 Aug 14. PMID: 16904878
Article Published Date : Sep 01, 2006
Study Type : Animal Study
Additional Links
Substances : Kava Kava
Additional Keywords : Herb Safety, Plant Extracts
[+]

Safety Study: Kava does not produce or aggravte liver injury.Jul 01, 2007

Pubmed Data : Food Chem Toxicol. 2007 Jul;45(7):1293-300. Epub 2007 Jan 26. PMID: 17353074
Article Published Date : Jul 01, 2007
Study Type : Animal Study
Additional Links
Substances : Kava Kava
Additional Keywords : Drug Synergy, Plant Extracts
[+]

A review of herbal therapy in multiple sclerosis.Oct 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Adv Pharm Bull. 2018 Nov ;8(4):575-590. Epub 2018 Nov 29. PMID: 30607330
Article Published Date : Oct 31, 2018
Study Type : Review
Additional Links
Substances : Cannabis, Cranberry, Frankincense, Ginger, Ginkgo biloba, Ginseng, Grape, Kava Kava, Nigella sativa (aka Black Seed), Saffron, St. Johns Wort, Turmeric, Valerian
Diseases : Multiple Sclerosis
[+]

A review of plants and substances that can modulate the endocannabinoid system.May 10, 2016

Pubmed Data : Trends Pharmacol Sci. 2016 May 11. Epub 2016 May 11. PMID: 27179600
Article Published Date : May 10, 2016
Study Type : Review
Additional Links
Substances : Black Pepper, Chocolate, Kava Kava
Pharmacological Actions : Endocannabinoid Modulator
[+]

Kava contains a compound inhibits the growth of bladder cancer cells. Nov 01, 2008

Pubmed Data : Cancer Prev Res (Phila). 2008 Nov;1(6):439-51. PMID: 19138991
Article Published Date : Nov 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Kava Kava
Diseases : Bladder Cancer, Cancers: Drug Resistant
Pharmacological Actions : Antineoplastic Agents, Cell cycle arrest
[+]

Kava contains a compound which induces programmed cell death in bladder cancer cells. Apr 15, 2005

Pubmed Data : Cancer Res. 2005 Apr 15;65(8):3479-86. PMID: 15833884
Article Published Date : Apr 15, 2005
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Kava Kava
Diseases : Bladder Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Plant Extracts
[+]

Kava contains a compound which induces programmed cell death in prostate cancer cells.Jun 01, 2007

Pubmed Data : Indian J Exp Biol. 2007 Jun;45(6):524-8. PMID: 20112340
Article Published Date : Jun 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Kava Kava
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Kava contains a compound which protects against neurodegeneration. May 01, 2010

Pubmed Data : Bioorg Med Chem. 2010 May 1;18(9):3133-9. Epub 2010 Mar 20. PMID: 20371185
Article Published Date : May 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Kava Kava
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
[+]

Kava contains compounds with Cyclooxygenase enzyme inhibitory and antioxidant properties.Jan 01, 2002

Pubmed Data : Phytomedicine. 2002 Jan;9(1):41-7. PMID: 11924763
Article Published Date : Jan 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Kava Kava
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Kava contains compunds which protect neural cells against Alzheimer associated amyloid beta-peptide induced neurotoxicity.Jun 01, 2008

Pubmed Data : Mol Pharmacol. 2008 Jun;73(6):1785-95. Epub 2008 Mar 11. PMID: 18334601
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Kava Kava
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Kava has anti-inflammatory properties used in traditional Fijian medicine to treat urinary tract infections and asthma.Apr 14, 2006

Pubmed Data : Biochem Pharmacol. 2006 Apr 14;71(8):1206-18. Epub 2006 Feb 7. PMID: 16464438
Article Published Date : Apr 14, 2006
Study Type : In Vitro Study
Additional Links
Substances : Kava Kava
Diseases : Asthma, Inflammation, Urinary Tract Infections
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Science Confirms Tradition
[+]

Kava may contribute to ameliorating cravings in drug addiction. Sep 01, 2001

Pubmed Data : Pac Health Dialog. 2001 Sep;8(2):335-9. PMID: 12180513
Article Published Date : Sep 01, 2001
Study Type : Review
Additional Links
Substances : Kava Kava
Diseases : Cocaine Withdrawal, Tobacco Addiction/Withdrawal
[+]

Safety Study: Kava does not display metabolic toxicity in a homogeneous cellular assay.Apr 01, 2004

Pubmed Data : Planta Med. 2004 Apr;70(4):289-92. PMID: 15095141
Article Published Date : Apr 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Kava Kava
Additional Keywords : Plant Extracts
[+]

Safety Study: Kava has a superior "risk-to-benefit" ratio compared to other drugs used to treat anxiety.Apr 15, 2004

Pubmed Data : Toxicol Lett. 2004 Apr 15;150(1):85-96. PMID: 15068826
Article Published Date : Apr 15, 2004
Study Type : Review
Additional Links
Substances : Kava Kava
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Safety Study: The association between kava use and liver toxicity appears to be weak. Oct 01, 2010

Pubmed Data : J Clin Pharm Ther. 2010 Oct;35(5):545-63. PMID: 20831679
Article Published Date : Oct 01, 2010
Study Type : Review
Additional Links
Substances : Kava Kava
[+]

The consumption of Kava by Fijians may contribute to their unusually low levels of cancer.May 01, 2003

Pubmed Data : Phytomedicine. 2003 May;10(4):309-17. PMID: 12809361
Article Published Date : May 01, 2003
Study Type : Review
Additional Links
Substances : Kava Kava
Diseases : Cancers: All
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Kava is well tolerated effective against female climacteric (menopausal) symptoms.Feb 10, 1991

Pubmed Data : Fortschr Med. 1991 Feb 10;109(4):119-22. PMID: 2029982
Article Published Date : Feb 10, 1991
Additional Links
Substances : Kava Kava
[+]

Kava may exert its favourable effects on anxiety by improving baroflex control of heart rate.Dec 01, 2001

Pubmed Data : J Psychopharmacol. 2001 Dec;15(4):283-6. PMID: 11769822
Article Published Date : Dec 01, 2001
Additional Links
Substances : Kava Kava
[+]

Kava was judged to be a safe and effective treatment for sleep disturbances associated with non-psychotic anxiety disorders.Feb 01, 2004

Pubmed Data : J Affect Disord. 2004 Feb;78(2):101-10. PMID: 14706720
Article Published Date : Feb 01, 2004
Additional Links
Substances : Kava Kava
[+]

Kava was judged to have a beneficial effect in the treatment of anxiety, tension and restlessness, without having any adverse effect on the liver.Nov 01, 2003

Pubmed Data : Phytomedicine. 2003 Nov;10(8):631-9 PMID: 14692723
Article Published Date : Nov 01, 2003
Additional Links
Substances : Kava Kava

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