Lettuce

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26 Diseases Researched for Lettuce

Name	AC	CK
Inflammation	3	13
Colon Cancer	3	12
Colorectal Cancer	3	12
Gingivitis	1	10
Insomnia	1	10
Periodontal Diseases	1	10
DNA damage	3	4
Sleep Disorders	2	4
Arthritis	1	2
Cardiovascular Diseases	1	2
Depression	1	2
Diabetes Mellitus: Type 2	1	2
Gastric Ulcer	1	2
Mercury Poisoning	1	2
Oxidative Stress	2	2
Rheumatoid Arthritis	1	2
Arteriosclerosis	1	1
Chemotherapy-Induced Toxicity: Cisplatin	1	1
Gastric Cancer	1	1
Gram-Negative Bacterial Infections	1	1
Gram-Positive Bacterial Infections	1	1
Insulin Resistance	1	1
Lipid Peroxidation	1	1
Liver Cancer	1	1
Lung Cancer	1	1
Testicular Injury: Chemical/Metal Induced	1	1

26 Pharmacological Actions Researched for Lettuce

Name	AC	CK
Anti-Inflammatory Agents	5	16
Hypnotics and Sedatives	2	12
Antioxidants	9	10
Chemopreventive	1	10
Antiproliferative	3	4
Neuroprotective Agents	2	3
Analgesics	1	2
Anti-Apoptotic	1	2
Anti-Ulcer Agents	1	2
Anticoagulants	1	2
Antidepressive Agents	1	2
Apoptotic	2	2
Gastroprotective	1	2
Hypoglycemic Agents	1	2
Interleukin-1 beta downregulation	1	2
Interleukin-6 Downregulation	1	2
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	2
Tumor Necrosis Factor (TNF) Alpha Inhibitor	1	2
Antimicrobial	1	1
Bcl-2 protein down-regulation	1	1
Cell cycle arrest	1	1
Chemoprotective Agents	1	1
Cytotoxic	1	1
Genoprotective	1	1
Insulin Sensitizers	1	1

Research Articles 26
Cumulative Knowledge Score 42
Overall Research Rating GOOD

View the Evidence:
26 Abstracts with Lettuce Research

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[+]

Dietary nitrate consumption may be a useful adjunct in the control of chronic gingivitis.Jun 30, 2016

Click here to read the entire abstract

Pubmed Data : J Clin Periodontol. 2016 Jul ;43(7):603-8. Epub 2016 May 10. PMID: 26969836

Article Published Date : Jun 30, 2016

Study Type : Human Study

Additional Links

Substances : Lettuce

Diseases : Gingivitis, Inflammation, Periodontal Diseases

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Dietary Nitrate Consumption

[+]

Lettuce seed decreased insomnia during pregnancy and could be recommended as a safe natural remedy for treatment of pregnancy-related insomnia.Dec 04, 2018

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2018 Dec 5 ;227:176-180. Epub 2018 Aug 30. PMID: 30172900

Article Published Date : Dec 04, 2018

Study Type : Human Study

Additional Links

Substances : Lettuce

Diseases : Insomnia

Pharmacological Actions : Hypnotics and Sedatives

Additional Keywords : Phytotherapy

[+]

Total vegetable intake, total fruit intake, and lettuce, apple, and banana consumption is associated with a reduced risk for colorectal cancer.Jan 01, 1996

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Pubmed Data : Nutr Cancer. 1996;25(3):297-304. PMID: 8771572

Article Published Date : Jan 01, 1996

Study Type : Human Study

Additional Links

Substances : Apples, Banana, Fruit: All, Lettuce, Vegetables: All

Diseases : Colon Cancer, Colorectal Cancer

Pharmacological Actions : Chemopreventive

[+]

A lettuce and skullcap mixture can be used as an herbal agent for sleep disorders.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biol Pharm Bull. 2018 ;41(8):1269-1276. PMID: 30068876

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Lettuce, Skullcap: Chinese

Diseases : Sleep Disorders

Additional Keywords : Plant Extracts

[+]

Arbuscular mycorrhizal could improve drought tolerance in lettuce and tomato plants. Aug 24, 2015

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Pubmed Data : Plant Cell Environ. 2015 Aug 25. Epub 2015 Aug 25. PMID: 26305264

Article Published Date : Aug 24, 2015

Study Type : Environmental

Additional Links

Substances : Lettuce, Tomato

Additional Keywords : Arbuscular Mycorrhizal Fungi

[+]

Feeding mice fed a high-fat/high-cholesterol diet lettuce resulted in an improvement of plasma cholesterol and lipid levels, prevention of lipid peroxidation and an increase of the antioxidant defence system. Apr 01, 2009

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Pubmed Data : Br J Nutr. 2009 Apr;101(8):1246-54. Epub 2009 Feb 25. PMID: 19243638

Article Published Date : Apr 01, 2009

Study Type : Animal Study

Additional Links

Substances : Lettuce

Diseases : Cardiovascular Diseases, DNA damage

Pharmacological Actions : Antioxidants

[+]

Fermented lettuce extract containing nitric oxide metabolites attenuates inflammatory parameters.Feb 22, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2023 Feb 23 ;15(5). Epub 2023 Feb 23. PMID: 36904105

Article Published Date : Feb 22, 2023

Study Type : Animal Study

Additional Links

Substances : Fermented Foods and Beverages, Lettuce

Diseases : Arthritis, Rheumatoid Arthritis

Pharmacological Actions : Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

Additional Keywords : Plant Extracts

[+]

Heukharang lettuce leaf extract displays sleep-promoting effects through GABAA receptor.Oct 04, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Ethnopharmacol. 2023 Oct 5 ;314:116602. Epub 2023 May 4. PMID: 37149068

Article Published Date : Oct 04, 2023

Study Type : Animal Study

Additional Links

Substances : Lettuce

Diseases : Sleep Disorders

Pharmacological Actions : Hypnotics and Sedatives

Additional Keywords : Plant Extracts

[+]

L. sativa can potentially act as a strong herbal drug due to its multiple pharmaceutical effects and is therefore of interest in drug discovery and development of formulations.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2015 ;15:199. Epub 2015 Jun 27. PMID: 26115918

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Lettuce

Diseases : Depression, Inflammation

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Anticoagulants, Antidepressive Agents

Additional Keywords : Natural Substances Versus Drugs

[+]

Lactuca scariola leaves could be a substitute for synthetic drugs to treat diabetic patients.Aug 25, 2015

Click here to read the entire abstract

Pubmed Data : J Basic Clin Physiol Pharmacol. 2015 Aug 26. Epub 2015 Aug 26. PMID: 26352090

Article Published Date : Aug 25, 2015

Study Type : Animal Study

Additional Links

Substances : Lettuce

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents

[+]

Launaea taraxacifolia mitigated mercuric chloride alteration of the microanatomy of rat brain.Nov 01, 2017

Click here to read the entire abstract

Pubmed Data : J Diet Suppl. 2017 Nov 2 ;14(6):613-625. Epub 2017 Mar 1. PMID: 28471730

Article Published Date : Nov 01, 2017

Study Type : Animal Study

Additional Links

Substances : Lettuce

Diseases : Mercury Poisoning

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts

Problem Substances : Mercury

[+]

Spectral analysis and antiulcer potential of Lactuca sativa through the amelioration of proinflammatory cytokines and apoptosis markers.Oct 18, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Life (Basel). 2022 Oct 19 ;12(10). Epub 2022 Oct 19. PMID: 36295076

Article Published Date : Oct 18, 2022

Study Type : Animal Study

Additional Links

Substances : Lettuce

Diseases : Gastric Ulcer

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Anti-Ulcer Agents, Gastroprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substances Versus Drugs

[+]

A phenolic extract of romaine lettuce protected PC-12 cells against oxidative stress.Jul 31, 2010

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Pubmed Data : J Med Food. 2010 Aug ;13(4):779-84. PMID: 20553182

Article Published Date : Jul 31, 2010

Study Type : In Vitro Study

Additional Links

Substances : Lettuce

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

A water-soluble fraction of lettuce exerts protective effects against glucose/serum deprivation-induced DNA damage.Apr 30, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Pol Pharm. 2014 May-Jun;71(3):409-13. PMID: 25265820

Article Published Date : Apr 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Lettuce

Diseases : DNA damage, Lipid Peroxidation

Pharmacological Actions : Antioxidants, Genoprotective

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Beneficial phytochemicals with anti-tumor potential revealed through metabolic profiling of new red pigmented lettuces.Apr 10, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2018 Apr 11 ;19(4). Epub 2018 Apr 11. PMID: 29641499

Article Published Date : Apr 10, 2018

Study Type : In Vitro Study

Additional Links

Substances : Lettuce

Diseases : Colon Cancer, Colorectal Cancer, Liver Cancer, Lung Cancer

Pharmacological Actions : Antioxidants, Cytotoxic

[+]

Iodine-biofortified lettuce regulates transcription of genes associated with cell cycle and apoptotic process leading to reduced Caco-2 cells proliferation.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2016 ;11(1):e0147336. Epub 2016 Jan 22. PMID: 26799209

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Iodine, Lettuce

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Gene Expression Regulation, Plant Extracts

[+]

Isolation and identification of antimicrobial substances from Korean Lettuce.May 31, 2018

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Pubmed Data : Food Sci Biotechnol. 2018 Jun ;27(3):789-797. Epub 2018 Jan 16. PMID: 30263805

Article Published Date : May 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Lettuce

Diseases : Gram-Negative Bacterial Infections, Gram-Positive Bacterial Infections

Pharmacological Actions : Antimicrobial

[+]

L. taraxacifolia could be used as a natural antioxidant and also as a preventive therapy against diseases such as arteriosclerosis associated with DNA damage.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Nat Sci Biol Med. 2018 Jan-Jun;9(1):6-13. PMID: 29456385

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Lettuce

Diseases : Arteriosclerosis, DNA damage

Pharmacological Actions : Antioxidants

Additional Keywords : Plant Extracts

[+]

L. taraxacifolia has protective potential against cisplatin damage.May 31, 2015

Click here to read the entire abstract

Pubmed Data : Andrologia. 2015 Jun ;47(5):553-9. Epub 2014 Jun 11. PMID: 24919929

Article Published Date : May 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Lettuce

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Plant Extracts

[+]

Lettuce extract significantly decreased reactive oxygen species, nitric oxide release, inducible nitric oxide synthase and cycloxygenase-2 expression.Jan 14, 2015

Click here to read the entire abstract

Pubmed Data : Food Chem. 2015 Jan 15 ;167:153-61. Epub 2014 Jul 4. PMID: 25148972

Article Published Date : Jan 14, 2015

Study Type : In Vitro Study

Additional Links

Substances : Lettuce, Polyphenols

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Plant Extracts

[+]

Lettuce-avicularin treatment reverses insulin resistance through stimulation of glycolytic kinases and insulin signaling molecules.Jan 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2021 Feb ;24(2):232-239. PMID: 33953863

Article Published Date : Jan 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Lettuce

Diseases : Insulin Resistance

Pharmacological Actions : Insulin Sensitizers

[+]

Molecular effects of iodine-biofortified lettuce in human gastrointestinal cancer cells.Oct 13, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Oct 14 ;14(20). Epub 2022 Oct 14. PMID: 36296971

Article Published Date : Oct 13, 2022

Study Type : In Vitro Study

Additional Links

Substances : Iodine, Lettuce

Diseases : Colon Cancer, Gastric Cancer

Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation

Additional Keywords : Epigenetic Modification In Cancer, Plant Extracts

[+]

Nutritional value of commercial and traditional lettuce (Lactuca sativa L.) and wild relatives: Vitamin C and anthocyanin content.Apr 19, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Chem. 2021 Apr 20 ;359:129864. Epub 2021 Apr 20. PMID: 33962194

Article Published Date : Apr 19, 2021

Study Type : Plant Study

Additional Links

Substances : Anthocyanins, Lettuce, Vitamin C, Wild Lettuce

[+]

Plants grown under 20% blue and 80% red had the highest accumulations of the following seven elements Ca, Mg, Na, Fe, Mn, Zn and B.Apr 30, 2014

Click here to read the entire abstract

Pubmed Data : Guang Pu Xue Yu Guang Pu Fen Xi. 2014 May ;34(5):1394-7. PMID: 25095445

Article Published Date : Apr 30, 2014

Study Type : Plant Study

Additional Links

Substances : Lettuce

Additional Keywords : Growing Your Own Food, Light-Emitting Diodes (LEDs)

[+]

Quercetin, green tea extract and grape seed extract acted synergistically in combination with lettuce extract against oxidation of peroxidating liposomes.Dec 31, 2015

Click here to read the entire abstract

Pubmed Data : Food Chem. 2016 Jan 1 ;190:25-32. Epub 2015 May 16. PMID: 26212937

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Grape Seed Extract, Green Tea, Lettuce, Polyphenols, Quercetin

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Natural Substance Synergy

[+]

This studies results showed the anti-inflammatory and antioxidant potential of Maravilla de Verano polyphenolic extracts.Jan 17, 2016

Click here to read the entire abstract

Pubmed Data : J Sci Food Agric. 2016 Jan 18. Epub 2016 Jan 18. PMID: 26777118

Article Published Date : Jan 17, 2016

Study Type : In Vitro Study

Additional Links

Substances : Lettuce

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Plant Extracts

Research Articles 26
Cumulative Knowledge Score 42
Overall Research Rating GOOD

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This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

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Focus Your Research

Click any topic below to filter + focus research

Lettuce is a Sub of the following Topic

View the Evidence: 26 Abstracts with Lettuce Research

Limited to Members Only

Currently Available Sorting Options

Dietary nitrate consumption may be a useful adjunct in the control of chronic gingivitis.Jun 30, 2016

Lettuce seed decreased insomnia during pregnancy and could be recommended as a safe natural remedy for treatment of pregnancy-related insomnia.Dec 04, 2018

Total vegetable intake, total fruit intake, and lettuce, apple, and banana consumption is associated with a reduced risk for colorectal cancer.Jan 01, 1996

A lettuce and skullcap mixture can be used as an herbal agent for sleep disorders.Dec 31, 2017

Arbuscular mycorrhizal could improve drought tolerance in lettuce and tomato plants. Aug 24, 2015

Feeding mice fed a high-fat/high-cholesterol diet lettuce resulted in an improvement of plasma cholesterol and lipid levels, prevention of lipid peroxidation and an increase of the antioxidant defence system. Apr 01, 2009

Fermented lettuce extract containing nitric oxide metabolites attenuates inflammatory parameters.Feb 22, 2023

Heukharang lettuce leaf extract displays sleep-promoting effects through GABAA receptor.Oct 04, 2023

L. sativa can potentially act as a strong herbal drug due to its multiple pharmaceutical effects and is therefore of interest in drug discovery and development of formulations.Dec 31, 2014

Lactuca scariola leaves could be a substitute for synthetic drugs to treat diabetic patients.Aug 25, 2015

Launaea taraxacifolia mitigated mercuric chloride alteration of the microanatomy of rat brain.Nov 01, 2017

Spectral analysis and antiulcer potential of Lactuca sativa through the amelioration of proinflammatory cytokines and apoptosis markers.Oct 18, 2022

A phenolic extract of romaine lettuce protected PC-12 cells against oxidative stress.Jul 31, 2010

A water-soluble fraction of lettuce exerts protective effects against glucose/serum deprivation-induced DNA damage.Apr 30, 2014

Beneficial phytochemicals with anti-tumor potential revealed through metabolic profiling of new red pigmented lettuces.Apr 10, 2018

Iodine-biofortified lettuce regulates transcription of genes associated with cell cycle and apoptotic process leading to reduced Caco-2 cells proliferation.Dec 31, 2015

Isolation and identification of antimicrobial substances from Korean Lettuce.May 31, 2018

L. taraxacifolia could be used as a natural antioxidant and also as a preventive therapy against diseases such as arteriosclerosis associated with DNA damage.Dec 31, 2017

L. taraxacifolia has protective potential against cisplatin damage.May 31, 2015

Lettuce extract significantly decreased reactive oxygen species, nitric oxide release, inducible nitric oxide synthase and cycloxygenase-2 expression.Jan 14, 2015

Lettuce-avicularin treatment reverses insulin resistance through stimulation of glycolytic kinases and insulin signaling molecules.Jan 31, 2021

Molecular effects of iodine-biofortified lettuce in human gastrointestinal cancer cells.Oct 13, 2022

Nutritional value of commercial and traditional lettuce (Lactuca sativa L.) and wild relatives: Vitamin C and anthocyanin content.Apr 19, 2021

Plants grown under 20% blue and 80% red had the highest accumulations of the following seven elements Ca, Mg, Na, Fe, Mn, Zn and B.Apr 30, 2014

Quercetin, green tea extract and grape seed extract acted synergistically in combination with lettuce extract against oxidation of peroxidating liposomes.Dec 31, 2015

This studies results showed the anti-inflammatory and antioxidant potential of Maravilla de Verano polyphenolic extracts.Jan 17, 2016

Lettuce Related Articles

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Lettuce

View the Evidence:
26 Abstracts with Lettuce Research