Licorice

Name	AC	CK
Oxidative Stress	28	65
Coronavirus Infection	26	55
Inflammation	35	53
Aphthous Ulcer	4	40
Liver Cancer	20	40
Nonalcoholic fatty liver disease (NAFLD)	11	38
Hepatitis C	8	36
Wound Healing	8	31
Breast Cancer	23	27
Obesity	13	27
Psoriasis	5	27
Helicobacter Pylori Infection	7	26
Diabetes Mellitus: Type 2	10	25
Liver Disease	4	25
Lipopolysaccharide-Induced Toxicity	15	23
Polycystic Ovary Syndrome	4	23
HIV Infections	4	22
Rosacea	3	21
Acute Respiratory Distress Syndrome	1	20
Chemotherapy-Induced Toxicity: Cisplatin	11	18
Coronavirus Disease (Covid-19)	8	16
Gastric Cancer	10	15
Liver Damage: Drug-Induced	7	15
Colorectal Cancer	9	14
Lung Cancer	13	14
Ulcerative Colitis	7	14
Alzheimer's Disease	10	13
Chemotherapy-Induced Toxicity: Doxorubicin	6	13
Colitis	7	13
Allergic Rhinitis	3	12
Brain Inflammation	7	12
Burns	2	12
Chemically-Induced Liver Damage	7	12
Dental Caries: Children	3	12
Hepatic Steatosis	2	12
Pneumonia	2	12
Steptococcus Mutans Infections	3	12
Cancers: All	10	11
Cancers: Drug Resistant	10	11
Cholesterol: Oxidation	2	11
Fatty Liver	6	11
Head and Neck Cancer	2	11
Prostate Cancer	8	11
Squamous cell carcinoma	11	11
Stroke: Ischemic	2	11
Addison's Disease	1	10
Anosmia	1	10
Bladder Cancer	8	10
Cytomegalovirus Infections	1	10
Duodenal Ulcer	1	10
Familial Mediterranean Fever	1	10
Hepatitis: Autoimmune	1	10
High Fat Diet	4	10
Hirsutism	1	10
Hot Flash	1	10
Menopausal Syndrome	1	10
Nicotine/Tobacco Toxicity	1	10
Oral Cancer	10	10
Oral Lichen Planus	1	10
Radiation Induced Illness: Mucositis	1	10
Smoking Cessation: Nicotine Addiction	1	10
Stomatitis: Aphthous	1	10
Testosterone: Too High	1	10
Vitiligo	1	10
Acetaminophen (Tylenol) Toxicity	5	9
Colon Cancer	7	9
Diabetic Complications	5	9
Glioma	6	9
Hyperglycemia	4	9
Diabetic Nephropathy	4	8
Liver Damage	5	8
Melanoma	8	8
Myocardial Ischemia	4	8
Sepsis	4	8
Aging	5	7
Cancer Metastasis	5	7
Carcinoma: Non-Small-Cell Lung	7	7
Cardiovascular Diseases	5	7
Chemotherapy-Induced Kidney Damage	3	7
Esophageal Cancer	5	7
Lung Damage	3	7
Neurodegenerative Diseases	6	7
Abdominal Obesity (Midsection Fat)	3	6
Asthma	4	6
Cervical Cancer	5	6
Influenza A	5	6
Insulin Resistance	4	6
Lung Injury: Acute	3	6
Multiple Sclerosis	3	6
Myocardial Infarction	3	6
Alcoholic Liver Disease	2	5
Arthritis	3	5
Atopic Dermatitis	3	5
Brain: Oxidative Stress	3	5
Chronic Obstructive Pulmonary Disease	2	5
Dysbiosis	3	5
Gastric Ulcer	2	5
Heart Failure	3	5
Inflammatory Bowel Diseases	3	5
Rheumatoid Arthritis	3	5
Salmonella Infections	3	5
Cardiac Hypertrophy	2	4
Cerebral Ischemia	2	4
Cognitive Decline/Dysfunction	2	4
Depression	2	4
Dyslipidemias	2	4
Epilepsy	2	4
Hyperlipidemia	2	4
Liver Fibrosis	2	4
Mastitis	2	4
Memory Disorders	2	4
Metabolic Diseases	2	4
Myocardial Fibrosis	2	4
Parkinson's Disease	3	4
Pulmonary Fibrosis: Bleomycin-Induced	2	4
Seizures	2	4
Staphylococcus aureus infection	4	4
Staphylococcus aureus: Methicillin-resistant (MRSA)	3	4
Acne	3	3
Allergies	2	3
Anxiety	2	3
Breast Cancer: Lung Metastasis	2	3
Breast Cancer: Triple Negative	3	3
Candida Albicans	3	3
Chemotherapy and Radiation Toxicity	2	3
Chemotherapy-Induced Toxicity: Paclitaxel	1	3
Encephalomyelitis	2	3
Endothelial Dysfunction	1	3
Hepatitis	2	3
Hepatitis: Lectin-Induced (concanavalin)	2	3
Influenza	3	3
Iron Poisoning	2	3
Liver Injury: Ischemia/reperfusion	2	3
Middle Cerebral Artery Occlusion (MCAO)	1	3
Musculoskeletal Diseases	1	3
Osteosarcoma	2	3
Periodontal Diseases	3	3
Respiratory Syncytial Virus Infections	3	3
SARS	2	3
Schistosomiasis	2	3
Skin Cancer	3	3
Alcohol Toxicity	1	2
Aneurysm: Aortic	1	2
Animal Diseases: Infectious	1	2
Atherosclerosis	2	2
Autoimmune Disease	1	2
Autoimmune Diseases	1	2
Bacterial Infections	2	2
Bleeding: Excessive	1	2
Brain Ischemia	1	2
Cancers: Multi-Drug Resistant	2	2
Candidiasis	1	2
Candidiasis: Vulvovaginal	2	2
Cardiac Arrhythmias	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Cholangiocarcinoma	2	2
Chronic Pain	1	2
Coronary Artery Disease	2	2
DNA damage	2	2
Drug Toxicity: Methotrexate	1	2
Endometrial Cancer	2	2
Enterovirus 71	1	2
Epstein-Barr Virus Infections	2	2
Escherichia coli Infections	2	2
Glyphosate Toxicity	1	2
H5N1 Infection	2	2
Hearing Loss	1	2
Hepatitis A	2	2
Herpes Simplex Virus Type 1	2	2
High Fructose Diet	1	2
Hypercholesterolemia	1	2
Hypertension	1	2
Infertility: Male	1	2
Kidney Cancer	2	2
Kidney Damage	2	2
Kidney Damage: Drug-Induced	1	2
Liver Damage: Aflatoxin-Induced	1	2
Liver Steatosis	1	2
Malaria	2	2
Metabolic Syndrome X	1	2
Microplastic Toxicity	1	2
Migraines	1	2
Nasopharyngeal Cancer	2	2
Neuropathic Pain	1	2
Newcastle Disease Virus	1	2
Non-Small-Cell Lung Carcinoma	2	2
Osteoarthritis	2	2
Osteoporosis	2	2
Ovarian Cancer	2	2
Overweight	1	2
Pancreatic Cancer	1	2
Pancreatitis	1	2
Periodontitis	2	2
Peripheral Neuropathies	1	2
Premature Birth	1	2
Pseudomonas aeruginosa	2	2
Puberty: Precocious	1	2
Pulmonary Fibrosis	2	2
Pulmonary Inflammation	1	2
Radiotherapy	1	2
Respiratory Distress Syndrome	1	2
Rotavirus Infections	2	2
Sciatic Nerve Crush Injury	1	2
Severe Acute Respiratory Syndrome	2	2
Skin Diseases: Photo-Aging	1	2
Spinal Cord Injuries	1	2
Stroke	1	2
Surgery: Oral	1	2
Tardive Dyskinesia	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Toxoplasma gondii Infection	1	2
Trigeminal Neuralgia	1	2
Tumors	1	2
Uranium Poisoning	1	2
Venous Thrombosis	1	2
Advanced Glycation End products (AGE)	1	1
Alopecia	1	1
Androgenic Alopecia	1	1
Bacillus subtilis infections	1	1
C-Reactive Protein	1	1
Candida Infection	1	1
Cholestasis	1	1
Common Cold	1	1
Degenerative Disk Disease	1	1
Dental Caries	1	1
Diabetic Retinopathy	1	1
Encephalitis: Japanese	1	1
Endometriosis	1	1
Enterovirus: Type 71	1	1
Estrogen Dominance	1	1
Fibroid Tumor	1	1
Fibroids: Uterine	1	1
Fibrosarcoma	1	1
Fungal Infection	1	1
Gastrointestinal Diseases	1	1
Heavy Metal Toxicity	1	1
Hepatitis B	1	1
Herpes Zoster	1	1
Herpex Simplex Virus	1	1
Huntington Disease	1	1
Hypoxia	1	1
IgE-Mediated Hypersensitivity	1	1
Influenza B	1	1
Insect Bites: Repellent	1	1
Iron Overload	1	1
Keloid	1	1
Leiomyoma	1	1
Leishmaniasis	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Lipid Peroxidation	1	1
Listeria Infections	1	1
Liver Cirrhosis	1	1
Lymphoma: B-Cell	1	1
Mesothelioma	1	1
Methicillin-resistant Staphylococcus aureus	1	1
Multiple Myeloma	1	1
Necrotising enterocolitis	1	1
Neuroblastoma	1	1
Peptic Ulcer	1	1
Peripheral Nerve Damage	1	1
Photooxidative Stress	1	1
Promyelocytic leukemia	1	1
Pseudorabies Herpesvirus	1	1
Silicosis	1	1
Staphylococcus epidermidis	1	1
Stomach Cancer	1	1
Thyroid Cancer	1	1
Traumatic Brain Injury	1	1
Tuberculosis	1	1
Ultraviolet Radiation Induced Damage	1	1
Vesicular Stomatitis Virus	1	1
HIV: Opportunist Infection.	1	0
Influenza: Human	1	0
Preventing Cavities	2	0

Name	AC	CK
Anti-Inflammatory Agents	129	226
Hepatoprotective	49	143
Antioxidants	71	139
Antiproliferative	91	114
Apoptotic	90	107
Antiviral Agents	52	104
Neuroprotective Agents	42	78
Cardioprotective	25	63
Tumor Necrosis Factor (TNF) Alpha Inhibitor	31	59
NF-kappaB Inhibitor	37	54
Interleukin-6 Downregulation	24	52
Anti-Bacterial Agents	22	44
Nrf2 activation	26	42
Chemopreventive	15	41
Interleukin-1 beta downregulation	24	37
Chemoprotective Agents	17	35
Immunomodulatory	17	32
Anti-Apoptotic	17	31
Cell cycle arrest	24	29
Gastrointestinal Agents	14	29
Analgesics	5	25
Angiotensin-Converting Enzyme Inhibitors	1	20
Anti-metastatic	18	20
Malondialdehyde Down-regulation	7	20
Hypoglycemic Agents	10	19
Antimicrobial	8	18
Antineoplastic Agents	14	17
Renoprotective	9	17
Anti-Fibrotic	8	16
Anti-Ulcer Agents	4	16
Heme oxygenase-1 up-regulation	9	16
Hypolipidemic	8	16
MicroRNA modulator	12	16
Radioprotective	4	15
Anti-Allergic Agents	3	13
Superoxide Dismutase Up-regulation	10	13
Chemotherapeutic	10	12
Gastroprotective	6	12
Autophagy Up-regulation	7	10
CYP3A enzyme induction	1	10
Cytoprotective	2	9
Interleukin-18 down-regulation	5	9
Matrix metalloproteinase-9 (MMP-9) inhibitor	6	9
Cyclooxygenase 2 Inhibitors	5	8
Interferon Gamma Reducer	4	8
Interleukin-17 downregulation	4	8
Anticarcinogenic Agents	4	6
SIRT1 Activator	4	6
Antifungal Agents	4	5
Antiparasitic Agents	3	5
Aromatase Inhibitors	3	5
Chemosensitizer	5	5
Enzyme Inhibitors	3	5
Angiogenesis Inhibitors	3	4
Antidepressive Agents	2	4
Bcl-2 protein down-regulation	4	4
Tumor Suppressor Protein p53 Upregulation	2	4
Vascular Endothelial Growth Factor Inhibitors	3	4
Cyclin D1 Down-Regulation	1	3
Insulin Sensitizers	2	3
Interleukin-10 upregulation	2	3
Interleukin-8 downregulation	2	3
Matrix metalloproteinase-2 (MMP-2) inhibitor	3	3
Osteoprotective	3	3
Transforming growth factor beta (TGF-β) inhibitor	2	3
Acetylcholinesterase Inhibitor	1	2
Anti-Anxiety Agents	1	2
Anticholesteremic Agents	1	2
Autophagy Inhibitors	1	2
Catalase Up-Regulation	1	2
Cholagogues and Choleretics	1	2
Detoxifier	1	2
Fertility Agents: Male	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	2
Immunomodulatory: Th17 downregulation	1	2
Immunostimulatory	2	2
Interleukin-12 downregulation	1	2
Interleukin-23 Downregulation	1	2
Interleukin-4 downregulation	1	2
Interleukin-5 downregulation	1	2
Phase II Detoxification Enzyme Inducer	1	2
Postaglandin PGE2 downregulation	2	2
Prophylactic Agents	1	2
Quorum Sensing Inhibition	2	2
STAT3 Inhibitor	2	2
Spermatogenic	1	2
Thrombolytic	1	2
interleukin-13 down-regulation	1	2
Alpha-glucosidase inhibitor	1	1
Anti-Adipogenic	1	1
Anti-Angiogenic	1	1
Anti-Glycation Agents	1	1
Anti-atherogenic	1	1
Antimalarials	1	1
Antimycobacterial	1	1
Antioxidant	1	1
Cyclooxygenase 1 Inhibitor	1	1
Cyclooxygenase Inhibitors	1	1
Cytotoxic	1	1
GABA Modulators	1	1
HIV Fusion Inhibitors	1	1
Hypnotics and Sedatives	1	1
Immunosuppressive Agents	1	1
Insect Repellents	1	1
Leishmanicidal	1	1
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	1
Multidrug Resistance Gene Modulators	1	1
Photoprotective	1	1
Proteasome Inhibitors	1	1
Radiosensitizer	1	1
Regenerative	1	1
Survivin Down-Regulation	1	1
Topoisomerase I inhibitor	1	1
Topoisomerase II Inhibitor	1	1

[+]

Licorice and liver function in patients with primary liver disease.Aug 31, 2024

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Pubmed Data : Phytother Res. 2024 Sep ;38(9):4614-4627. Epub 2024 Jul 30. PMID: 39079711

Article Published Date : Aug 31, 2024

Pharmacological Actions : Hepatoprotective

[+]

Effective licorice gargle juice for aphthous ulcer pain relief.Aug 31, 2022

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Pubmed Data : Pak J Pharm Sci. 2022 Sep ;35(5):1321-1326. PMID: 36451559

Article Published Date : Aug 31, 2022

Study Type : Human Study

Additional Links

Substances : Licorice

Diseases : Aphthous Ulcer

Pharmacological Actions : Analgesics

Additional Keywords : Plant Extracts

[+]

Effects of licorice root supplementation on liver enzymes, hepatic steatosis, metabolic and oxidative stress parameters in women with nonalcoholic fatty liver disease.Sep 30, 2022

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Pubmed Data : Phytother Res. 2022 Oct ;36(10):3949-3956. Epub 2022 Jul 3. PMID: 35785498

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Medicine (Baltimore). 2019 Aug ;98(35):e16601. PMID: 31464895

Article Published Date : Jul 31, 2019

Study Type : Human Study

Additional Links

Substances : Fermented Foods and Beverages, Lactobacillus paracasei, Licorice

Diseases : Helicobacter Pylori Infection

Pharmacological Actions : Anti-Inflammatory Agents

[+]

G. glabra extracts showed good anticandidal activity and also high antioxidant property which reduces the oxidative stress of HIV-infected people.Oct 31, 2017

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Pubmed Data : J Pharm Bioallied Sci. 2017 Nov ;9(Suppl 1):S237-S240. PMID: 29284971

Article Published Date : Oct 31, 2017

Study Type : Human Study

Additional Links

Substances : Licorice

Diseases : HIV Infections, Oxidative Stress

Pharmacological Actions : Antimicrobial, Antioxidants

[+]

[+]

Glycyrrhizin prevents hemorrhagic transformation and improves neurological outcome in ischemic stroke with delayed thrombolysis.Dec 23, 2019

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Pubmed Data : Transl Stroke Res. 2019 Dec 24. Epub 2019 Dec 24. PMID: 31872339

Article Published Date : Dec 23, 2019

Study Type : Animal Study, Human Study

Additional Links

Substances : Glycyrrhizin

Diseases : Stroke: Ischemic

Pharmacological Actions : Neuroprotective Agents

[+]

Impact of licorice root on the burn healing process.Apr 30, 2023

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Pubmed Data : Complement Ther Med. 2023 May ;73:102941. Epub 2023 Mar 2. PMID: 36870516

Article Published Date : Apr 30, 2023

Study Type : Human Study

Additional Links

Substances : Licorice

Diseases : Burns, Wound Healing

Additional Keywords : Plant Extracts

[+]

Licorce - Safety Study. Jun 01, 2007

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Pubmed Data : J Am Coll Nutr. 2007 Jun;26(3):209-18. PMID: 17634165

Article Published Date : Jun 01, 2007

Study Type : Human Study

Additional Links

Substances : Licorice

[+]

Licorice contains the compound glycyrrhizin which has significantly inhibits HIV replication in the peripheral blood mononuclear cells from HIV-seropositive patients. Jan 01, 2002

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Pubmed Data : Pathobiology. 2002-2003;70(4):229-36. PMID: 12679601

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Pubmed Data : Gen Dent. 2008 Mar-Apr;56(2):206-10; quiz 211-2, 224. PMID: 18348383

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Pubmed Data : Practitioner. 1975 Dec;215(1290):787-92. PMID: 772652

Article Published Date : Dec 01, 1975

Study Type : Human Study

Additional Links

Substances : Licorice

Diseases : Duodenal Ulcer

Pharmacological Actions : Anti-Ulcer Agents

[+]

Licorice root extract inhibits adhesion of Helicobacter pylori to human gastric mucosa.Sep 07, 2009

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Pubmed Data : J Ethnopharmacol. 2009 Sep 7;125(2):218-23. Epub 2009 Jul 14. PMID: 19607905

Article Published Date : Sep 07, 2009

Study Type : Human Study

Additional Links

Substances : Licorice

Diseases : Helicobacter Pylori Infection

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Plant Extracts

[+]

[+]

Nebulized glycyrrhizin/enoxolone drug modulates IL-17A in COVID-19 patients.Dec 31, 2022

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Pubmed Data : Front Immunol. 2023 ;14:1282280. Epub 2024 Jan 12. PMID: 38283346

Article Published Date : Dec 31, 2022

Study Type : Human Study

Additional Links

Substances : Glycyrrhizin

Diseases : Coronavirus Disease (Covid-19)

Pharmacological Actions : Antiviral Agents, Immunomodulatory, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Cytokine Storm

[+]

Pomegranate and licorice drinks could increase the metabolism rate for nicotine.Sep 27, 2016

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Pubmed Data : J Pharm Biomed Anal. 2016 Sep 28 ;132:60-65. Epub 2016 Aug 28. PMID: 27693954

Article Published Date : Sep 27, 2016

Study Type : Human Study

Additional Links

Substances : Licorice, Pomegranate

Diseases : Nicotine/Tobacco Toxicity , Smoking Cessation: Nicotine Addiction

[+]

Role of aromatic herbs and spices in salty perception of patients with hyposmia.Nov 22, 2022

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Pubmed Data : J Ethnopharmacol. 2025 Feb 11 ;341:119337. Epub 2025 Jan 7. PMID: 39788166

Article Published Date : Feb 10, 2025

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Glycyrrhizin

Diseases : Colitis, Colorectal Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Glycyrrhizin ameliorates colorectal cancer progression.Oct 22, 2024

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[+]

Licorice extract isoliquiritigenin protects endothelial function in type 2 diabetic mice.Sep 18, 2024

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Pubmed Data : Nutrients. 2024 Sep 19 ;16(18). Epub 2024 Sep 19. PMID: 39339760

Article Published Date : Sep 18, 2024

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Licorice

Diseases : Diabetes Mellitus: Type 2, Endothelial Dysfunction, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Liquiritin attenuates pathological cardiac hypertrophy.Dec 31, 2021

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Pubmed Data : Front Pharmacol. 2022 ;13:870699. Epub 2022 May 3. PMID: 35592411

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Pubmed Data : Molecules. 2022 Jun 14 ;27(12). Epub 2022 Jun 14. PMID: 35744945

Article Published Date : Jun 13, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Flavonoids, Licorice

Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Chemoprotective Agents, Renoprotective

[+]

"A glycyrrhizin-containing preparation reduces hepatic steatosis induced by hepatitis C virus protein and iron in mice."Apr 01, 2011

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Pubmed Data : Liver Int. 2011 Apr ;31(4):552-60. Epub 2011 Feb 15. PMID: 21382166

Article Published Date : Apr 01, 2011

Study Type : Animal Study

Additional Links

Substances : Glycyrrhizin

Diseases : Fatty Liver, Hepatitis C, Iron Poisoning, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents

[+]

An herbal formula containing Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum and Urtica dioica may dental surgery bleedings. Apr 01, 2009

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Oct 8 ;14(19). Epub 2022 Oct 8. PMID: 36235833

Article Published Date : Oct 07, 2022

Study Type : Animal Study

Additional Links

Substances : Glycyrrhizin, Licorice

Diseases : High Fat Diet, Nonalcoholic fatty liver disease (NAFLD), Obesity

Pharmacological Actions : Gastrointestinal Agents, Hepatoprotective, Hypolipidemic

Additional Keywords : Plant Extracts

[+]

Extracts from leaves of Glycyrrhiza glabra have strong antiviral activity against Newcastle disease virus in vivo.Feb 28, 2017

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Pubmed Data : Pak J Pharm Sci. 2017 Mar ;30(2(Suppl.)):567-572. PMID: 28650322

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Pubmed Data : Biomed Pharmacother. 2019 Feb ;110:692-699. Epub 2018 Dec 12. PMID: 30553196

Article Published Date : Jan 31, 2019

Study Type : Animal Study

Additional Links

Substances : Glycyrrhizin

Diseases : Hepatitis: Lectin-Induced (concanavalin)

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interferon Gamma Reducer, Interleukin-17 downregulation, Interleukin-6 Downregulation

Problem Substances : Concanavalin A

[+]

Glycyrrhizin alleviates non-alcoholic steatohepatitis.Jun 28, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:8438528. Epub 2022 Apr 7. PMID: 35432719

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Glycyrrhizin

Diseases : Brain Inflammation , Brain Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

[+]

Glycyrrhizin attenuates Salmonella typhimurium-induced tissue injury.Dec 31, 2020

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Pubmed Data : Shock. 2009 Apr;31(4):367-75. PMID: 18665052

Article Published Date : Apr 01, 2009

Study Type : Animal Study

Additional Links

Substances : Licorice

Diseases : Spinal Cord Injuries

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Glycyrrhizin has been proven to be a strong antioxidant as well as antiapoptotic and cytoprotective against CIS testicular damage.Dec 31, 2024

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Pubmed Data : J Cell Mol Med. 2020 Jan ;24(1):214-226. Epub 2019 Oct 27. PMID: 31657123

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Glycyrrhizin

Diseases : Chemotherapy and Radiation Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Radioprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Glycyrrhizin modulates chronic seizures-induced memory dysfunction.Aug 30, 2021

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Pubmed Data : ACS Chem Neurosci. 2021 Aug 31. Epub 2021 Aug 31. PMID: 34463468

Article Published Date : Aug 30, 2021

Study Type : Animal Study

Additional Links

Substances : Glycyrrhizin

Diseases : Memory Disorders, Seizures

Pharmacological Actions : Neuroprotective Agents

[+]

Hepatoprotective triterpene saponins from the roots of Glycyrrhiza inflata.Apr 08, 2015

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Pubmed Data : Molecules. 2015 Apr 9 ;20(4):6273-83. Epub 2015 Apr 9. PMID: 25859783

Article Published Date : Apr 08, 2015

Study Type : Animal Study

Additional Links

Substances : Licorice

Diseases : Liver Damage

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

[+]

Hesperetin and isoliquiritigenin attenuate the progression of diabetic nephropathy.Aug 11, 2025

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Ethnopharmacol. 2021 Mar 4 ;273:113989. Epub 2021 Mar 4. PMID: 33677006

Article Published Date : Mar 03, 2021

Study Type : Animal Study, In Vitro Study

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Substances : Licorice

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

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Licochalcone A inhibits the growth of colon carcinoma and attenuates cisplatin-induced toxicity.Jun 30, 2008

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Pubmed Data : Phytomedicine. 2020 May 22 ;76:153245. Epub 2020 May 22. PMID: 32505917

Article Published Date : May 21, 2020

Study Type : Animal Study, In Vitro Study

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Substances : Licorice

Diseases : Lung Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, MicroRNA modulator

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Licochalcone A suppresses hexokinase 2-mediated tumor glycolysis in gastric cancer via downregulation of the Akt signaling pathway.Feb 28, 2018

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Pubmed Data : Iran J Pharm Res. 2015 ;14(4):1163-70. PMID: 26664383

Additional Keywords : Plant Extracts

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Pubmed Data : World J Hepatol. 2020 Sep 27 ;12(9):596-618. PMID: 33033567

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Pubmed Data : Bioorg Med Chem. 2017 10 15 ;25(20):5522-5530. Epub 2017 Aug 15. PMID: 28835349

Article Published Date : Jan 14, 2017

Study Type : Animal Study

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Substances : Licorice

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Additional Keywords : Plant Extracts

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Oral administration of coconut oil and licorice extract may impede hyperlipidemia and hepatosteatosis through curtailing hepatic lipid synthesis.Oct 09, 2018

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Pubmed Data : J Agric Food Chem. 2018 Oct 10 ;66(40):10447-10457. Epub 2018 Oct 2. PMID: 30244576

Article Published Date : Oct 09, 2018

Study Type : Animal Study

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Substances : Coconut Oil, Licorice

Diseases : Hyperlipidemia

Additional Keywords : Plant Extracts

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Pubmed Data : Indian J Pharmacol. 2015 Jan-Feb;47(1):39-44. PMID: 25821309

Article Published Date : Dec 31, 2014

Study Type : Animal Study

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Substances : Glycyrrhizin, Spirulina

Diseases : Cognitive Decline/Dysfunction, Obesity

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Natural Substance Synergy

Problem Substances : Monosodium Glutamate (MSG)

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Spleen-targeted glabridin-loaded nanoparticles for the treatment of cerebral ischemia-reperfusion injury.Aug 31, 2022

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Pubmed Data : J Agric Food Chem. 2024 Feb 7 ;72(5):2741-2755. Epub 2024 Jan 29. PMID: 38284775

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Pubmed Data : Iran J Basic Med Sci. 2020 Sep ;23(9):1232-1238. PMID: 32963746

Article Published Date : Aug 31, 2020

Study Type : Animal Study

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Substances : Glycyrrhizin

Diseases : Liver Injury: Ischemia/reperfusion

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation

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The protective role of liquiritin in high fructose-induced myocardial fibrosis.Nov 30, 2016

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Pubmed Data : Biomed Pharmacother. 2016 Dec ;84:1337-1349. Epub 2016 Nov 1. PMID: 27810791

Article Published Date : Nov 30, 2016

Study Type : Animal Study, In Vitro Study

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Substances : Licorice

Diseases : High Fructose Diet, Inflammation, Insulin Resistance, Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Cardioprotective, NF-kappaB Inhibitor

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The regulatory Effects of licochalcone A on the intestinal epithelium and gut microbiota in murine colitis.Jul 07, 2021

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Pubmed Data : Pharmacol Ther. 2020 10 ;214:107618. Epub 2020 Jun 24. PMID: 32592716

Article Published Date : Jan 09, 2020

Study Type : In Vitro Study

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Substances : Glycyrrhizin

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

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"Glycyrrhizic acid (GA), a triterpenoid saponin glycoside alleviates ultraviolet-B irradiation-induced photoaging in human dermal fibroblasts."May 14, 2012

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Pubmed Data : Phytomedicine. 2012 May 15 ;19(7):658-64. Epub 2012 Apr 18. PMID: 22516896

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Pubmed Data : Front Pharmacol. 2020 ;11:744. Epub 2020 May 15. PMID: 32499711

Article Published Date : Dec 31, 2019

Study Type : Review

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Substances : Curcumin, Frankincense, Licorice, Lion's Mane (Hericium Erinaceus), Medicinal Mushrooms, Reishi Mushroom

Diseases : Bladder Cancer, Breast Cancer, Cancers: All, Colitis, Dysbiosis, Esophageal Cancer, Lung Cancer

Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Chemopreventive, Gastrointestinal Agents

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Additional Keywords : Plant Extracts

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Anti-quorum sensing effects of licochalcone A and epigallocatechin-3-gallate against Salmonella Typhimurium.Dec 31, 2019

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Pubmed Data : Vet Res Forum. 2020 ;11(3):273-279. Epub 2020 Sep 15. PMID: 33133465

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

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Substances : EGCG (Epigallocatechin gallate), Licorice

Diseases : Salmonella Infections

Pharmacological Actions : Anti-Bacterial Agents, Quorum Sensing Inhibition

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Antibacterial effect and mode of action of flavonoids from licorice against methicillin-resistant Staphylococcus aureus.Dec 31, 2018

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Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Can antiviral activity of licorice help fight COVID-19 infection? Jan 07, 2021

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Pubmed Data : Biomolecules. 2021 06 8 ;11(6). Epub 2021 Jun 8. PMID: 34201172

Article Published Date : Jan 07, 2021

Study Type : Review

Additional Links

Substances : Glycyrrhizin

Diseases : Coronavirus Infection

Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents

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View the Evidence: 571 Abstracts with Licorice Research

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Licorice and liver function in patients with primary liver disease.Aug 31, 2024

Compound glycyrrhizin plus conventional therapy for psoriasis vulgaris.Dec 31, 2016

A Chinese herbal formula containing Paris polyphylla, Dandelion, Woad, and Licorice appears safe and effective in reducing cytomegalovirus infection activity in pregnant women. Apr 01, 2000

A multi antioxidative treatment in chronic hepatitis C virus patients is well tolerated and therapeutic. Sep 01, 2005

A skin care regimen containing the Licorice compound Licochalcone A was found to be compatible with the sensitive facial skin of patients with rosacea and improved the appearance of persistent facial redness.Nov 01, 2009

Administration of glycyrrhizin resulted in a modest induction of CYP3A that was clinically relevant according to the bioequivalence analysis.Jul 31, 2010

An extract of Glycyrrhiza can be effective for decreasing the severity of oral mucositis in head and neck cancer patients undergoing radiotherapy.Aug 31, 2017

An extract of Paeoniae radix and Glycyrrhizae radix could be benefical in patients with early age-related macular degeneration.Mar 31, 2021

Andrographis, Eleutherococcus (Siberian Ginseng), Schisandra and Glycyrrhiza (Licorice) is safe and efficacious in the management of Familial Mediterranean Fever.Aug 01, 2008

Compared with the hormone treatment, glycyrrhizic acid preparation might be a safe and effective treatment for autoimmune hepatitis.Jan 17, 2023

Effective licorice gargle juice for aphthous ulcer pain relief.Aug 31, 2022

Effects of licorice root supplementation on liver enzymes, hepatic steatosis, metabolic and oxidative stress parameters in women with nonalcoholic fatty liver disease.Sep 30, 2022

Efficacy of diammonium glycyrrhizinate combined with vitamin C for treating hospitalized COVID-19 patients.Jul 25, 2021

Efficacy of diammonium glycyrrhizinate in the treatment of rosacea with papules and pustules.Nov 30, 2022

Fermented milk containing Lactobacillus paracasei and Glycyrrhiza glabra has a beneficial effect in patients with Helicobacter pylori infection.Jul 31, 2019

G. glabra extracts showed good anticandidal activity and also high antioxidant property which reduces the oxidative stress of HIV-infected people.Oct 31, 2017

Glabridin, a compound found within licorice, inhibits LDL oxidation. May 01, 2009

Glycerrhiza glabra (syn. Licorice) is therapeutic in patients with protracted pulmonary pneumonia. Sep 01, 2001

Glycyrrhizin alleviates the toxicity of hydroxychloroquine in treating oral lichen planus.Nov 30, 2024

Glycyrrhizin and ultraviolet B light therapy improved active-stage generalized vitiligo.Jul 24, 2016

Glycyrrhizin prevents hemorrhagic transformation and improves neurological outcome in ischemic stroke with delayed thrombolysis.Dec 23, 2019

Impact of licorice root on the burn healing process.Apr 30, 2023

Licorce - Safety Study. Jun 01, 2007

Licorice contains the compound glycyrrhizin which has significantly inhibits HIV replication in the peripheral blood mononuclear cells from HIV-seropositive patients. Jan 01, 2002

Licorice flavonoid oil enhances fat oxidation in humans during light exercise.Dec 31, 2014

Licorice may be an effective alternative to the pharmaceutical preparation amlexanox in treating aphthous ulcers.Jan 01, 2008

Licorice reduces pain and lesion size in recurrent aphthous ulcers.Mar 01, 2008

Licorice reduces pain, inflammation and necrosis in aphthous ulcers.Feb 01, 2009

Licorice reduces serum testosterone in healthy women. Oct 01, 2004

Licorice reduces the side effects of spironolactone in the treatment of polycystic ovary syndrome. Mar 01, 2007

Licorice reverses duodenal ulceration.Dec 01, 1975

Licorice root extract inhibits adhesion of Helicobacter pylori to human gastric mucosa.Sep 07, 2009

Licorice seems more effective than HRT in improving hot flash duration, but that HRT can reduce the duration and severity of hot flashes more than licorice. Dec 31, 2013

Liquorice and soy sauce has been reported a life-saving concoction in a patient with Addison's disease.Jun 30, 2007

Liquorice intake modulates ACE2 and HMGB1 levels in healthy individuals.Dec 31, 2021

Long term administration of a licorice extract in the treatment of chronic hepatitis C is effective in preventing liver carcinogenesis.Apr 15, 1997

Long term administration of a licorice extract in the treatment of chronic hepatitis C is effective in preventing liver cirrhosis and hepatocellular carcinoma.Jan 01, 2002

Nasal irrigation with Glycyrrhiza glabra extract for treatment of allergic rhinitis.Apr 17, 2021

Nebulized glycyrrhizin/enoxolone drug modulates IL-17A in COVID-19 patients.Dec 31, 2022

Pomegranate and licorice drinks could increase the metabolism rate for nicotine.Sep 27, 2016

Role of aromatic herbs and spices in salty perception of patients with hyposmia.Nov 22, 2022

The effects of licorice containing diphenhydramine solution on recurrent aphthous stomatitis.Apr 30, 2020

There was a significant drop in liver enzymes in patients with non-alcoholic fatty liver disease following administration of licorice root extract.Aug 31, 2012

Twice-daily use of a Licorice lollipop significantly reduced the number and percent of Streptococcus mutans in high-risk children. Dec 01, 2010

[Extraction of miRNA from Glycyrrhiza uralensis Decoction and Its Effect on Immune Cells].Jun 30, 2015

Glycyrrhizin ameliorates vascular endothelial cell senescence by inhibiting HMGB1 in HFD/STZ-induced diabetes.Sep 14, 2022

A synergistic mechanism of Liquiritin and Licochalcone B from Glycyrrhiza uralensis against COPD.Apr 19, 2024

Bioactive glycyrrhizic acid-astragalus polysaccharide hydrogel facilitates gastric ulcer healing.Aug 14, 2025

Breast cancer prevention with liquiritigenin from licorice.May 29, 2023

Glabridin induces glucose uptake via the AMP-activated protein kinase pathway in muscle cells.Aug 04, 2014

Glabridin inhibits urothelial bladder carcinoma cell growth.Sep 12, 2022

Glycyrrhizic acid alleviates gefitinib-induced liver injury.May 31, 2025

Glycyrrhizic acid inhibits hippocampal neuron apoptosis.Oct 07, 2024

Glycyrrhizic acid mitigates hepatocyte steatosis and inflammation.Sep 04, 2025

Glycyrrhizic acid prevents paclitaxel-induced neuropathy.Apr 24, 2023

Glycyrrhizic acid reduces neutrophil extracellular trap formation to ameliorate colitis-associated colorectal cancer.Feb 10, 2025

Glycyrrhizin ameliorates colorectal cancer progression.Oct 22, 2024

Glycyrrhizin mitigates acute lung injury by inhibiting the NLRP3 inflammasome.Feb 28, 2023

Isoliquiritigenin inhibits the activation of the ANXA2/STAT3 pathway by down-regulating TAGLN2, thereby alleviating alcoholic fatty liver.Nov 30, 2025

Licochalcone A alleviates ferroptosis in doxorubicin-induced cardiotoxicity.Dec 10, 2023

Licochalcone a improves cardiac functions after ischemia-reperfusion.Oct 14, 2023

Licochalcone A induces ferroptosis in hepatocellular carcinoma.Dec 31, 2022

Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer.Nov 04, 2023

Licochalcone A inhibits glioma migration, invasion, and growth by triggering mitochondrial dysfunction and ROS-mediated oxidative damage.Nov 30, 2025

Licoflavone A suppresses gastric cancer growth and metastasis.Dec 31, 2021

Licorice extract isoliquiritigenin protects endothelial function in type 2 diabetic mice.Sep 18, 2024

Liquiritin attenuates pathological cardiac hypertrophy.Dec 31, 2021

Liquiritin exhibits anti-acute lung injury activities.Apr 02, 2023

Liquiritin reduces ferroptosis in doxorubicin-induced cardiotoxicity.May 08, 2023

Protective effects of liquiritigenin against cisplatin-induced nephrotoxicity.Jun 13, 2022

"A glycyrrhizin-containing preparation reduces hepatic steatosis induced by hepatitis C virus protein and iron in mice."Apr 01, 2011

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View the Evidence:
571 Abstracts with Licorice Research