Lignans

Name	AC	CK
Breast Cancer	10	27
Inflammation	6	26
Oxidative Stress	10	22
High Cholesterol	2	20
Breast Cancer: Prevention	4	15
Prostate Cancer	4	15
Abdominal Obesity (Midsection Fat)	2	14
Rheumatoid Arthritis	2	12
Cardiovascular Diseases	2	11
Cholesterol: LDL/HDL ratio	1	10
Cholesterol: Oxidation	1	10
Chronic Fatigue Syndrome	1	10
Diabetes Mellitus: Type 2	1	10
Esophageal Cancer	1	10
Fatigue	1	10
Fibroids: Uterine	1	10
Herpes Simplex Virus Type 1	1	10
Hormone Imbalances	1	10
Hot Flash	1	10
Hypertension	1	10
Incontinence	1	10
Insulin Resistance	1	10
Menopausal Syndrome	1	10
Prostate Cancer: Prevention	1	10
Colon Cancer	6	8
Cancers: All	5	6
Adiponectin: Low Levels	1	4
Aging	3	4
Atherosclerosis	2	4
Estrogen Dominance	3	4
Fatty Liver	1	4
Liver Damage	3	4
Lupus Nephritis	1	4
Acetaminophen (Tylenol) Toxicity	1	2
Aflatoxicosis	1	2
Aortic Aneurysm	1	2
Arthritis	1	2
Brain Damage	1	2
Breast Cancer: Chemically-Induced	1	2
Breast Cancer: Triple Negative	2	2
Chemically-Induced Liver Damage	1	2
Cognitive Decline/Dysfunction	1	2
Endothelial Dysfunction	1	2
HIV Infections	2	2
Intestinal Cancer	1	2
Kidney Damage: Chemically-Induced	1	2
Lipopolysaccharide-Induced Toxicity	2	2
Liver Cancer	2	2
Liver Damage: Aflatoxin-Induced	1	2
Liver Damage: Drug-Induced	1	2
Lung Cancer	2	2
Metabolic Syndrome X	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Myocardial Infarction	1	2
Neurodegenerative Diseases	1	2
Nicotine/Tobacco Toxicity	1	2
Prostatic Hyperplasia: Benign	1	2
Radiation-induced illness: Lung	1	2
Uterine Cancer	1	2
Alcohol Toxicity	1	1
Alzheimer's Disease	1	1
Brain: Microglial Activation	1	1
Cancer Metastasis	1	1
Cancers: Drug Resistant	1	1
Cancers: Multi-Drug Resistant	1	1
Chlamydia pneumoniae	1	1
Chlamydia trachomatis	1	1
Cholestasis	1	1
Colorectal Cancer	1	1
Estrogen Deficiency	1	1
Hypoxia	1	1
Leukemia	1	1
Liver Cancer: Prevention	1	1
Myocardial Ischemia	1	1
Pneumonia	1	1
Promyelocytic leukemia	1	1

Name	AC	CK
Antioxidants	17	51
Antiproliferative	11	25
Anticarcinogenic Agents	5	16
Chemopreventive	6	16
Anti-Inflammatory Agents	8	12
Vascular Endothelial Growth Factor A Inhibitor	2	12
Anticholesteremic Agents	2	11
Antihypertensive Agents	2	11
Hepatoprotective	7	11
Anti-Infective Agents	1	10
Antiviral Agents	1	10
Neuroprotective Agents	6	9
Apoptotic	6	8
Cyclooxygenase 2 Inhibitors	4	8
Cell cycle arrest	5	6
Cyclooxygenase 1 Inhibitor	3	6
Interleukin-6 Downregulation	4	6
Superoxide Dismutase Up-regulation	2	6
Tumor Necrosis Factor (TNF) Alpha Inhibitor	3	6
Cardioprotective	3	5
Anti-Adipogenic	1	4
Antineoplastic Agents	2	4
Aromatase Inhibitors	3	4
NF-kappaB Inhibitor	4	4
Tumor Suppressor Protein p53 Upregulation	2	3
15-Lipoxygenase (15-LOX) Inhibitor	1	2
Anti-HIV Agents	2	2
Anti-metastatic	2	2
Chemosensitizer	2	2
Chemotherapeutic	2	2
Cyclin D1 Down-Regulation	1	2
Cyclooxygenase Inhibitors	1	2
Interleukin-10 upregulation	1	2
Malondialdehyde Down-regulation	1	2
Matrix Metalloproteinase-12 (MMP-12) Inhibitor	1	2
Prostaglandin PGE2 downregulation	1	2
Proteasome Inhibitors	1	2
Radioprotective	1	2
Renoprotective	1	2
STAT3 Inhibitor	2	2
Anti-Apoptotic	1	1
Anti-Bacterial Agents	1	1
Antimicrobial	1	1
Estrogen Receptor Modulators	1	1
Heme oxygenase-1 up-regulation	1	1
Immunomodulatory	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1
Multidrug Resistance Gene Modulators	1	1
Tyrosinase Inhibition	1	1
Wnt/β-catenin signaling pathway modulation	1	1

[+]

Sesamin can be used as an obtainable dietary supplement to improve blood pressure and blood lipids.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Endocrinol (Lausanne). 2022 ;13:842152. Epub 2022 Mar 4. PMID: 35311241

Article Published Date : Dec 31, 2021

Study Type : Meta Analysis, Review

Additional Links

Substances : Lignans

Diseases : Cardiovascular Diseases, Hypertension, Obesity

Pharmacological Actions : Antihypertensive Agents, Hypolipidemic

[+]

A flaxseed-derived lignan supplement has therapeutic value in type 2 diabetics. Nov 07, 2007

Click here to read the entire abstract

Pubmed Data : PLoS One. 2007 Nov 7;2(11):e1148. PMID: 17987126

Article Published Date : Nov 07, 2007

Study Type : Human Study

Additional Links

Substances : Flaxseed, Lignans

Diseases : Diabetes Mellitus: Type 2

[+]

A lignan rich diet reduces body mass index, abdominal fat and insulin resistance in post-menopausal women. Sep 01, 2001

Click here to read the entire abstract

Pubmed Data : Mutat Res. 2001 Sep 1;480-481:201-7. PMID: 19586570

Article Published Date : Sep 01, 2001

Study Type : Human Study

Additional Links

Substances : Lignans

Diseases : Abdominal Obesity (Midsection Fat), Insulin Resistance

[+]

Antihypertensive effects of sesamin in humansJan 31, 2009

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2009 Feb ;55(1):87-91. PMID: 19352068

Article Published Date : Jan 31, 2009

Study Type : Human Study

Additional Links

Substances : Lignans

Diseases : high blood pressure, Hypertension

Pharmacological Actions : Antihypertensive Agents

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Flaxseed consumption was associated with a longer luteal phase and a higher luteal phase progesterone-to-estradiol ratio.Nov 01, 1993

Click here to read the entire abstract

Pubmed Data : J Clin Endocrinol Metab. 1993 Nov ;77(5):1215-9. PMID: 8077314

Article Published Date : Nov 01, 1993

Study Type : Human Study

Additional Links

Substances : Lignans

Diseases : Hormone Imbalances

[+]

Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men.Jun 30, 2010

Click here to read the entire abstract

Pubmed Data : Nutr Res. 2010 Jul ;30(7):441-6. PMID: 20797475

Article Published Date : Jun 30, 2010

Study Type : Human Study

Additional Links

Substances : Flaxseed, Lignans

Diseases : Cardiovascular Diseases, Hypercholesterolemia, Liver Damage

Pharmacological Actions : Anticholesteremic Agents, Hepatoprotective

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Flaxseed may reduce circulating total and LDL-cholesterol levels.Aug 01, 2009

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 2009 Aug;90(2):288-97. Epub 2009 Jun 10. PMID: 19515737

Article Published Date : Aug 01, 2009

Study Type : Human Study

Additional Links

Substances : Flaxseed, Lignans

Diseases : Cholesterol: LDL/HDL ratio, High Cholesterol

Pharmacological Actions : Anticholesteremic Agents

[+]

Flaxseed meal and flaxseed extract is effective in reducing menopausal symptoms without increasing blood levels of follicle stimulating hormone and estradiol, as well as in the endometrial thickness, and vaginal epithelial maturation value.Aug 31, 2012

Click here to read the entire abstract

Pubmed Data : J Med Food. 2012 Sep ;15(9):840-5. PMID: 22925074

Article Published Date : Aug 31, 2012

Study Type : Human Study

Additional Links

Substances : Flaxseed, Secoisolariciresinol diglucoside (SDG)

Diseases : Hot Flash, Menopausal Syndrome

[+]

Flaxseed modulates inflammatory and oxidative stress biomarkers in cystic fibrosis.May 12, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2015 May 13 ;15:148. Epub 2015 May 13. PMID: 25963404

Article Published Date : May 12, 2015

Study Type : Human Study

Additional Links

Substances : Flaxseed, Lignans, Omega-3 Fatty Acids

Diseases : Cystic Fibrosis, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer.Mar 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Med Food. 2013 Apr ;16(4):357-60. PMID: 23566060

Article Published Date : Mar 31, 2013

Study Type : Human Study

Additional Links

Substances : Enterolactone, Flaxseed, Lignans

Diseases : Prostate Cancer, Prostate Cancer: Prevention

Pharmacological Actions : Antiproliferative , Chemopreventive, Vascular Endothelial Growth Factor A Inhibitor

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Greater consumption of total and individual lignans and dietary fibers were significantly associated with lowered risk of hip fracture.Mar 04, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Mar 5 ;14(5). Epub 2022 Mar 5. PMID: 35268074

Article Published Date : Mar 04, 2022

Study Type : Human Study

Additional Links

Substances : Fiber, Lignans

Diseases : Fractures: Bone

Additional Keywords : Risk Reduction

[+]

High dietary intakes of plant lignans and high exposure to enterolignans were associated with reduced risks of ER- and PR-positive postmenopausal breast cancer. Mar 21, 2007

Click here to read the entire abstract

Pubmed Data : J Natl Cancer Inst. 2007 Mar 21;99(6):475-86. PMID: 17374837

Article Published Date : Mar 21, 2007

Study Type : Human Study

Additional Links

Substances : Enterodiol, Enterolactone, Flaxseed, Lignans, phytoestrogens

Diseases : Breast Cancer, Breast Cancer: Prevention

Additional Keywords : Risk Reduction

[+]

Lignan content of the flaxseed influences its biological effects in healthy men and women.May 31, 2013

Click here to read the entire abstract

Pubmed Data : J Am Coll Nutr. 2013 Jun ;32(3):194-9. PMID: 23885993

Article Published Date : May 31, 2013

Study Type : Human Study

Additional Links

Substances : Flaxseed, Lignans

Diseases : Cholesterol: Oxidation, High Cholesterol

[+]

lignan phytoestrogens may have a protective effect against incontinence in postmenopausal women.Sep 30, 2015

Click here to read the entire abstract

Pubmed Data : Urology. 2015 Oct ;86(4):716-20. Epub 2015 Jul 29. PMID: 26232691

Article Published Date : Sep 30, 2015

Study Type : Human Study

Additional Links

Substances : Lignans

Diseases : Incontinence

Additional Keywords : Risk Reduction

[+]

Long-term flaxseed lignan-enriched complex supplementation in older adults has an ability to favourably modulate systolic blood pressure.Oct 31, 2017

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Pubmed Data : J Am Coll Nutr. 2017 Nov-Dec;36(8):646-653. Epub 2017 Sep 18. PMID: 28922068

Article Published Date : Oct 31, 2017

Study Type : Human Study

Additional Links

Substances : Flaxseed, Lignans

Diseases : Cardiovascular Diseases, Hypertension, Inflammation

Pharmacological Actions : Antihypertensive Agents

Additional Keywords : Risk Reduction

[+]

Pine cone lignin and ascorbic acid combination has a potent antiviral activity, promoting faster healing, reduction of symptoms and reducing the frequency of recurrence episodes in HSV-1.Oct 31, 2009

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : In Vivo. 2009 Nov-Dec;23(6):1011-6. PMID: 20023248

Article Published Date : Oct 31, 2009

Study Type : Human Study

Additional Links

Substances : Lignans, Pine Cone, Vitamin C

Diseases : Herpes Simplex Virus Type 1

Pharmacological Actions : Anti-Infective Agents, Antiviral Agents

Additional Keywords : Natural Substance Synergy, Plant Extracts, Recurrence Risk, Significant Treatment Outcome

[+]

Rheumatoid patients subjectively benefited from the vegan diet rich in antioxidants, lactobacilli and fibre.Nov 29, 2000

Click here to read the entire abstract

Pubmed Data : Toxicology. 2000 Nov 30 ;155(1-3):45-53. PMID: 11156742

Article Published Date : Nov 29, 2000

Study Type : Human Study

Additional Links

Substances : Carotenoids, Fiber, Flavonoids, Lignans

Diseases : Inflammation, Rheumatoid Arthritis

Therapeutic Actions : Dietary Modification: Vegetarian

Pharmacological Actions : Antioxidants

[+]

Sesame lignans with vitamin E supplementation could safely alleviate daily fatigue and oxidative stress.Mar 24, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Glob J Health Sci. 2015 Mar 25 ;7(6):1-10. Epub 2015 Mar 25. PMID: 26153159

Article Published Date : Mar 24, 2015

Study Type : Human Study

Additional Links

Substances : Lignans, Sesame Seeds

Diseases : Chronic Fatigue Syndrome, Fatigue, Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

The results of the present study indicate that a dietary pattern characterised by the intake of lignans, quercetin and resveratrol may play a protective role in the development of oesophageal cancersNov 30, 2014

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Pubmed Data : Br J Nutr. 2014 Dec ;112(12):2002-9. Epub 2014 Oct 27. PMID: 25345471

Article Published Date : Nov 30, 2014

Study Type : Human Study

Additional Links

Substances : Lignans, Quercetin, Resveratrol

Diseases : Esophageal Cancer

Pharmacological Actions : Anticarcinogenic Agents

Additional Keywords : Dietary Modification, Natural Substance Synergy, Plant Extracts

[+]

There is a modest inverse association between lignan excretion and uterine fibroid risk. Jan 01, 2005

Click here to read the entire abstract

Pubmed Data : Cytotechnology. 2005 Jan;47(1-3):97-105. PMID: 16960173

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Substances : Daidzein, Enterodiol, Enterolactone, Equol, Genistein, Isoflavones, Lignans

Diseases : Fibroids: Uterine

[+]

Arctigenin attenuates ischemia/reperfusion induced ventricular arrhythmias.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Physiol Biochem. 2018 ;49(2):728-742. Epub 2018 Aug 30. PMID: 30165360

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Lignans

Diseases : Myocardial Infarction, Oxidative Stress

Pharmacological Actions : Antioxidants, Cardioprotective, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

[+]

Dietary flaxseed may be chemopreventive for intestinal and colon tumor development in mice possibly by increasing omega -3 fatty acid levels, lignans, and decreasing COX-1 and COX-2 levels.Jan 01, 2009

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2009;61(2):276-83. PMID: 19235044

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Flaxseed, Lignans, Omega-3 Fatty Acids

Diseases : Colon Cancer, Intestinal Cancer

Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors

[+]

Dietary flaxseed meal containing high levels of omega-3 fatty acids and lignans is effective in preventing colon tumor development when compared with dietary corn meal possibly by increasing omega-3 fatty acid levels and decreasing COX-1 and COX-2 levels.Jan 01, 2006

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2006;54(2):216-22. PMID: 16898866

Article Published Date : Jan 01, 2006

Study Type : Animal Study

Additional Links

Substances : Flaxseed, Lignans, Omega-3 Fatty Acids

Diseases : Colon Cancer

Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors

[+]

Dietary phytochemicals have a beneficial effect on benign prostatic hyperplasia prevention.Nov 30, 2016

Click here to read the entire abstract

Pubmed Data : Appl Physiol Nutr Metab. 2016 Dec ;41(12):1303-1310. Epub 2016 Sep 27. PMID: 27849354

Article Published Date : Nov 30, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Flaxseed, Lignans

Diseases : Prostatic Hyperplasia: Benign

Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation, Tumor Suppressor Protein p53 Upregulation

[+]

Enterolactone and enterodiol have been shown to negate the tumor-stimulating effect of genistein in a mouse model of breast cancer.Jul 01, 2007

Click here to read the entire abstract

Pubmed Data : Mol Nutr Food Res. 2007 Jul;51(7):845-56. PMID: 17579892

Article Published Date : Jul 01, 2007

Study Type : Animal Study

Additional Links

Substances : Enterodiol, Enterolactone, Flaxseed, Genistein, Isoflavones, Lignans, phytoestrogens, Soy Protein

Diseases : Breast Cancer, Breast Cancer: Prevention

Pharmacological Actions : Antineoplastic Agents, Antiproliferative

[+]

Flaxseed and its lignans have potent antiestrogenic effects on estrogen receptor-positive breast cancer and may prove to be beneficial in breast cancer prevention strategies in the future.Feb 01, 2007

Click here to read the entire abstract

Pubmed Data : Clin Cancer Res. 2007 Feb 1;13(3):1061-7. PMID: 17289903

Article Published Date : Feb 01, 2007

Study Type : Animal Study

Additional Links

Substances : Enterodiol, Enterolactone, Flaxseed, Lignans

Diseases : Breast Cancer, Breast Cancer: Prevention

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Vascular Endothelial Growth Factor A Inhibitor

[+]

Flaxseed has radioprotective properties against lung injury. Oct 28, 2012

Click here to read the entire abstract

Pubmed Data : Radiat Res. 2012 Oct 29. Epub 2012 Oct 29. PMID: 23106213

Article Published Date : Oct 28, 2012

Study Type : Animal Study

Additional Links

Substances : Flaxseed, Secoisolariciresinol diglucoside (SDG)

Diseases : Radiation-induced illness: Lung

Pharmacological Actions : Radioprotective

[+]

Flaxseed lignan attenuates high-fat diet-induced visceral and liver fat accumulation and induces adiponectin expression in mice.Sep 01, 2008

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2008 Sep;100(3):669-76. Epub 2008 Feb 6. PMID: 18252024

Article Published Date : Sep 01, 2008

Study Type : Animal Study

Additional Links

Substances : Enterodiol, Flaxseed, Lignans, Secoisolariciresinol diglucoside (SDG)

Diseases : Abdominal Obesity (Midsection Fat), Adiponectin: Low Levels, Fatty Liver

Pharmacological Actions : Anti-Adipogenic

[+]

Lig-8, a bioactive lignophenol derivative from bamboo lignin, protects against neuronal damage in vitro and in vivo.Oct 01, 2006

Click here to read the entire abstract

Pubmed Data : J Pharmacol Sci. 2006 Oct;102(2):196-204. Epub 2006 Oct 7. PMID: 17031070

Article Published Date : Oct 01, 2006

Study Type : Animal Study

Additional Links

Substances : Bamboo, Lignans

Diseases : Brain Damage, Neurodegenerative Diseases

Pharmacological Actions : Apoptotic, Neuroprotective Agents, Proteasome Inhibitors

[+]

Lignan transformation by gut bacteria lowers tumor burden in a gnotobiotic rat model of breast cancer.Dec 31, 2011

Click here to read the entire abstract

Pubmed Data : Carcinogenesis. 2012 Jan ;33(1):203-8. Epub 2011 Nov 10. PMID: 22080573

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Lignan-converting bacteria , Lignans, Secoisolariciresinol diglucoside (SDG)

Diseases : Breast Cancer

Pharmacological Actions : Superoxide Dismutase Up-regulation

Additional Keywords : Bacterial Biotransformation

[+]

Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans.Aug 31, 2015

Click here to read the entire abstract

Pubmed Data : Phytochemistry. 2015 Sep ;117:340-350. Epub 2015 Jul 1. PMID: 26141518

Article Published Date : Aug 31, 2015

Study Type : Animal Study

Additional Links

Substances : Burdock, Lignans

Diseases : Aging, Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Pharmacological effects of natural components against ovarian cancer and mechanisms.Dec 31, 2020

Click here to read the entire abstract

Pubmed Data : Adv Exp Med Biol. 2021 ;1330:55-73. PMID: 34339030

Article Published Date : Dec 31, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ellagic Acid, Lignans, Luteolin, Mangiferin

Diseases : Ovarian Cancer

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Protective effects of gomisin A isolated from Schisandra chinensis against CCl(4)-induced hepatic and renal injury.Mar 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Med. 2013 Apr ;31(4):888-98. Epub 2013 Jan 31. PMID: 23381504

Article Published Date : Mar 31, 2013

Study Type : Animal Study

Additional Links

Substances : Lignans, Schisandra

Diseases : Chemically-Induced Liver Damage, Kidney Damage: Chemically-Induced

Pharmacological Actions : Hepatoprotective, Renoprotective

[+]

Protective role of flaxseed oil and flaxseed lignan secoisolariciresinol diglucoside against oxidative stress in rats with metabolic syndrome.Nov 30, 2017

Click here to read the entire abstract

Pubmed Data : J Food Sci. 2017 Dec ;82(12):3029-3036. Epub 2017 Oct 30. PMID: 29083494

Article Published Date : Nov 30, 2017

Study Type : Animal Study

Additional Links

Substances : Flaxseed, Lignans

Diseases : Metabolic Syndrome X, Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Rye lignan reduces estradiol-induced uterine growth.Aug 01, 2009

Click here to read the entire abstract

Pubmed Data : Mol Nutr Food Res. 2009 Aug;53(8):996-1006. PMID: 19603405

Article Published Date : Aug 01, 2009

Study Type : Animal Study

Additional Links

Substances : Isoflavones, Lignans, Rye

Diseases : Estrogen Dominance, Uterine Cancer

[+]

Schisandrol B promotes liver regeneration after partial hepatectomy in mice.Jan 04, 2018

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2018 Jan 5 ;818:96-102. Epub 2017 Oct 21. PMID: 29066412

Article Published Date : Jan 04, 2018

Study Type : Animal Study

Additional Links

Substances : Lignans, Schisandra

Diseases : Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Liver Regeneration

[+]

Secoisolariciresinol diglucoside is effective in slowing the progression of atherosclerosis and partially effective in regression of hypercholesterolemic atherosclerosis.Dec 01, 2010

Click here to read the entire abstract

Pubmed Data : Curr Pharm Biotechnol. 2010 Dec;11(8):794-800. PMID: 20874684

Article Published Date : Dec 01, 2010

Study Type : Animal Study

Additional Links

Substances : Flaxseed, Secoisolariciresinol diglucoside (SDG)

Diseases : Atherosclerosis

Pharmacological Actions : Cardioprotective

Additional Keywords : Disease Regression

[+]

Sesame extract may be effective in preventing abdominal aortic aneurysm development.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Oleo Sci. 2019 ;68(1):79-85. PMID: 30606956

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Lignans

Diseases : Aortic Aneurysm, Nicotine/Tobacco Toxicity

Pharmacological Actions : Antioxidants, Matrix Metalloproteinase-12 (MMP-12) Inhibitor

Additional Keywords : Plant Extracts

[+]

Sesame lignans inhibit delta-5 desaturase activity, increasing dihomo-gamma-linoleic acid levels and decreasing prostaglandin E2 synthesis.Mar 01, 1998

Click here to read the entire abstract

Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 1998 Mar ;58(3):185-91. PMID: 9610840

Article Published Date : Mar 01, 1998

Study Type : Animal Study

Additional Links

Substances : Lignans

Pharmacological Actions : Prostaglandin PGE2 downregulation

Additional Keywords : Anti-Inflammatory Agents, arachidonic acid, Gamma-Linoleic Acid GLA, Inflammation, Prostaglandin E2

[+]

Sesame lignans suppress age-related cognitive decline in senescence-accelerated mice.Jul 11, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2019 Jul 12 ;11(7). Epub 2019 Jul 12. PMID: 31336975

Article Published Date : Jul 11, 2019

Study Type : Animal Study

Additional Links

Substances : Lignans, Sesame Seeds

Diseases : Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

[+]

Sesamin alleviates asthma airway inflammation by regulating mitophagy and mitochondrial apoptosis.Apr 26, 2022

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2022 Apr 27 ;70(16):4921-4933. Epub 2022 Apr 14. PMID: 35420033

Article Published Date : Apr 26, 2022

Study Type : Animal Study

Additional Links

Substances : Lignans

Diseases : Asthma, Inflammation

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-4 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats.Jan 05, 2010

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2010 Jan 5;183(1):255-63. PMID: 19835851

Article Published Date : Jan 05, 2010

Study Type : Animal Study

Additional Links

Substances : Lignans

Diseases : Middle Cerebral Artery Occlusion (MCAO)

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

Sesamin lignan reduced the growth of human breast tumors at high levels of circulating estrogen in athymic mice.Dec 31, 2011

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2012 ;64(1):65-71. Epub 2011 Dec 2. PMID: 22136581

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Lignans, Sesamin

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Sesamin may prevent the development of atherosclerosis and inflammatory responsesSep 01, 2010

Click here to read the entire abstract

Pubmed Data : Mol Nutr Food Res. 2010 Sep ;54(9):1340-50. PMID: 20306475

Article Published Date : Sep 01, 2010

Study Type : Animal Study

Additional Links

Substances : Lignans, Sesamol

Diseases : Atherosclerosis, Endothelial Dysfunction

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Soy and rye diets have an inhibitory effect on the development of prostate cancer in rats.Jan 01, 2008

Click here to read the entire abstract

Pubmed Data : Med Princ Pract. 2008;17(2):131-5. Epub 2008 Feb 19. PMID: 9687986

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Lignans, phytoestrogens, Rye, Soy Protein

Diseases : Prostate Cancer

Pharmacological Actions : Chemopreventive

[+]

Targeted lignan profiling and anti-inflammatory properties of Schisandra rubriflora and Schisandra chinensis extracts.Nov 26, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2018 Nov 27 ;23(12). Epub 2018 Nov 27. PMID: 30486445

Article Published Date : Nov 26, 2018

Study Type : Animal Study

Additional Links

Substances : Lignans, Schisandra

Diseases : Inflammation

Pharmacological Actions : 15-Lipoxygenase (15-LOX) Inhibitor, Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors

Additional Keywords : Plant Extracts

[+]

The lignan precursor from flaxseed known as secoisolariresinol diglucoside (SDG) may inhibit the progression of lupus nephritis. Jan 01, 2000

Click here to read the entire abstract

Pubmed Data : Lupus. 2000;9(6):429-36. PMID: 10981647

Article Published Date : Jan 01, 2000

Study Type : Animal Study

Additional Links

Substances : Enterodiol, Enterolactone, Flaxseed, Lignans, Secoisolariciresinol diglucoside (SDG)

Diseases : Lupus Nephritis

[+]

Therapeutic effects of standardized Vitex negundo seeds extract on complete Freund's adjuvant induced arthritis.May 14, 2014

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2014 May 15 ;21(6):838-46. Epub 2014 Mar 25. PMID: 24680620

Article Published Date : May 14, 2014

Study Type : Animal Study

Additional Links

Substances : Lignans, Vitex negundo

Diseases : Arthritis, Inflammation, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-10 upregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Phytotherapy, Plant Extracts

[+]

These results suggest that gomisin A protects the liver from injury after administration of acetaminophen through the suppression of lipid peroxidation.Sep 13, 1993

Click here to read the entire abstract

Pubmed Data : Biochem Pharmacol. 1993 Sep 14 ;46(6):1081-5. PMID: 8216352

Article Published Date : Sep 13, 1993

Study Type : Animal Study

Additional Links

Substances : Lignans, Schisandra

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Treatment with SDG normalized several biomarkers in mammary gland tissue, dysplasia, cell number, and expression of several genes that had been altered by carcinogen.May 25, 2015

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2015 May 26:1-8. Epub 2015 May 26. PMID: 26010915

Article Published Date : May 25, 2015

Study Type : Animal Study

Additional Links

Substances : Flaxseed, Lignans

Diseases : Breast Cancer, Breast Cancer: Chemically-Induced

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative

Additional Keywords : Dietary Modification, Gene Expression Regulation

[+]

Turmeric and curcumin reverse aflatoxin-induced liver damage.Aug 01, 1992

Click here to read the entire abstract

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 1992 Aug;38(4):353-63. PMID: 1291640

Article Published Date : Aug 01, 1992

Study Type : Animal Study

Additional Links

Substances : Curcumin, Lignans

Diseases : Aflatoxicosis, Liver Damage: Aflatoxin-Induced

Pharmacological Actions : Hepatoprotective

[+]

Sesamolin promotes cytolysis and migration activity of natural killer cells via dendritic cells.Mar 31, 2020

Click here to read the entire abstract

Pubmed Data : Arch Pharm Res. 2020 Apr ;43(4):462-474. Epub 2020 Apr 11. PMID: 32279231

Article Published Date : Mar 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Sesame Seeds

Diseases : Cancers: All

Pharmacological Actions : Immunomodulatory

[+]

A hot-water extract of I. obliquus had anti-tumor activities. Feb 28, 2015

Click here to read the entire abstract

Pubmed Data : Int J Biol Macromol. 2015 Mar ;74:507-14. Epub 2015 Jan 10. PMID: 25583019

Article Published Date : Feb 28, 2015

Study Type : In Vitro Study

Additional Links

Substances : Chaga Mushroom (Inonotus obliquus), Lignans

Diseases : Cancers: All

Pharmacological Actions : Antiproliferative , Cell cycle arrest, NF-kappaB Inhibitor

[+]

An extract from schisandra chinensis berries inhibited the growth of both C. pneumoniae and C. trachomatis.May 31, 2015

Click here to read the entire abstract

Pubmed Data : Nat Prod Commun. 2015 Jun ;10(6):1001-4. PMID: 26197536

Article Published Date : May 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Schisandra

Diseases : Chlamydia pneumoniae , Chlamydia trachomatis, Pneumonia

Pharmacological Actions : Anti-Bacterial Agents, Antimicrobial

Additional Keywords : Dose Response, Plant Extracts

[+]

Anti-HIV-1 activity of lignans from the fruits of Schisandra rubriflora.Apr 30, 2010

Click here to read the entire abstract

Pubmed Data : Arch Pharm Res. 2010 May ;33(5):697-701. Epub 2010 May 29. PMID: 20512467

Article Published Date : Apr 30, 2010

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Schisandra

Diseases : HIV Infections

Pharmacological Actions : Anti-HIV Agents

[+]

Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells.Oct 14, 2013

Click here to read the entire abstract

Pubmed Data : Bioorg Med Chem Lett. 2013 Oct 15 ;23(20):5511-4. Epub 2013 Aug 22. PMID: 24018191

Article Published Date : Oct 14, 2013

Study Type : In Vitro Study

Additional Links

Substances : Honeysuckle, Lignans

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Wnt/β-catenin signaling pathway modulation

[+]

Antioxidant lignans from the seeds of Vitex negundoDec 31, 2013

Click here to read the entire abstract

Pubmed Data : J Asian Nat Prod Res. 2014 ;16(9):963-9. Epub 2014 Jun 26. PMID: 24965780

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Vitex negundo

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Arctigenin exerts neuroprotective effect by ameliorating cortical activities in experimental autoimmune encephalomyelitis.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Immunol. 2021 ;12:691590. Epub 2021 Jul 19. PMID: 34349758

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Lignans

Diseases : Multiple Sclerosis

Pharmacological Actions : Neuroprotective Agents

[+]

Comparative effects of sesame lignans (sesamin, sesamolin, and sesamol) on oxidative stress and lipid metabolism in steatosis HepG2 cells.Apr 08, 2022

Click here to read the entire abstract

Pubmed Data : J Food Biochem. 2022 Apr 9:e14180. Epub 2022 Apr 9. PMID: 35396857

Article Published Date : Apr 08, 2022

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Sesamin, Sesamol

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective, Hypolipidemic

[+]

Curcumin exhibits estrogen-like activity.Jan 01, 2010

Click here to read the entire abstract

Pubmed Data : Cell Physiol Biochem. 2010;26(3):471-82. Epub 2010 Aug 24. PMID: 20798532

Article Published Date : Jan 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Lignans, Quercetin

Diseases : Estrogen Deficiency

Pharmacological Actions : Estrogen Receptor Modulators

[+]

Dibenzocyclooctadiene lignans from the fruits of Schisandra rubriflora and their anti-HIV-1 activities.Apr 30, 2011

Click here to read the entire abstract

Pubmed Data : J Asian Nat Prod Res. 2011 May ;13(5):393-9. PMID: 21534036

Article Published Date : Apr 30, 2011

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Schisandra

Diseases : HIV Infections

Pharmacological Actions : Anti-HIV Agents

[+]

Dietary lignans reduce breask cancer risk. Jul 01, 2007

Click here to read the entire abstract

Pubmed Data : Mol Nutr Food Res. 2007 Jul;51(7):857-66. PMID: 17576639

Article Published Date : Jul 01, 2007

Study Type : Review

Additional Links

Substances : Enterodiol, Enterolactone, Lignans

Diseases : Breast Cancer: Prevention

Pharmacological Actions : Chemopreventive

[+]

Enterolactone suppresses lung cancer cell motility and invasion by altering FAK activity.Jan 08, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2017 Jan 9 ;17(1):30. Epub 2017 Jan 9. PMID: 28068967

Article Published Date : Jan 08, 2017

Study Type : In Vitro Study

Additional Links

Substances : Flaxseed, Lignans

Diseases : Cancer Metastasis, Lung Cancer

Pharmacological Actions : Anti-metastatic

Additional Keywords : gene express, Plant Extracts

[+]

Flaxseed lignans enhance the cytotoxicity of chemotherapeutic agents against breast cancer cell lines MDA-MB-231 and SKBR3.Jan 31, 2018

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2018 Feb-Mar;70(2):306-315. Epub 2018 Jan 5. PMID: 29303360

Article Published Date : Jan 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Flaxseed, Lignans

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Chemosensitizer, Chemotherapeutic

[+]

Gomisin A inhibits lipopolysaccharide-induced inflammatory responses in N9 microglia.Dec 31, 2013

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2014 Jan ;63:119-27. Epub 2013 Nov 7. PMID: 24211520

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Schisandra

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Gomisin A modulates aging progress via mitochondrial biogenesis in human diploid fibroblast cells.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : Clin Exp Pharmacol Physiol. 2018 06 ;45(6):547-555. Epub 2018 Feb 13. PMID: 29319901

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Schisandra

Diseases : Aging, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor

[+]

Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3.Sep 04, 2018

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2018 Sep 5 ;834:176-187. Epub 2018 Jul 20. PMID: 30036533

Article Published Date : Sep 04, 2018

Study Type : In Vitro Study

Additional Links

Substances : Honokiol, Lignans

Diseases : Liver Damage, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

[+]

Honokiol: An anticancer lignan.Oct 31, 2018

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2018 Nov ;107:555-562. Epub 2018 Aug 13. PMID: 30114639

Article Published Date : Oct 31, 2018

Study Type : Review

Additional Links

Substances : Honokiol, Lignans

Diseases : Cancers: All

Pharmacological Actions : Anti-Inflammatory Agents, Chemotherapeutic, NF-kappaB Inhibitor

[+]

Identification of methanol-soluble compounds in sesame and evaluation of antioxidant potential of its lignans.Apr 13, 2011

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2011 Apr 13 ;59(7):3214-9. Epub 2011 Mar 10. PMID: 21391595

Article Published Date : Apr 13, 2011

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Sesame Seeds, Sesamol

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

JWH-015, THC, CBD, Abn-CBD and O-1602 all protected SH-SY5Y cells from BV-2 conditioned media activated via LPS.Dec 31, 2013

Click here to read the entire abstract

Pubmed Data : Cell Mol Neurobiol. 2014 Jan ;34(1):31-42. Epub 2013 Sep 13. PMID: 24030360

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Cannabidiol, Cannabinoids , Delta-tetrahydrocannabinol (THC), Lignans

Diseases : Brain: Microglial Activation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Neuroprotective Agents

[+]

Lignans and flavonoids act as aromatase inhibitors in human preadipocytes. Aug 01, 1994

Click here to read the entire abstract

Pubmed Data : J Steroid Biochem Mol Biol. 1994 Aug;50(3-4):205-12. PMID: 8049151

Article Published Date : Aug 01, 1994

Study Type : In Vitro Study

Additional Links

Substances : Enterodiol, Flavonoids, Lignans

Diseases : Breast Cancer, Estrogen Dominance

Pharmacological Actions : Aromatase Inhibitors

[+]

Lignans are involved in the antitumor activity of wheat bran in colon cancer cells.Mar 01, 2005

Click here to read the entire abstract

Pubmed Data : J Nutr. 2005 Mar;135(3):598-602. PMID: 15735100

Article Published Date : Mar 01, 2005

Study Type : In Vitro Study

Additional Links

Substances : Fiber, Lignans, Wheat Bran

Diseases : Colon Cancer

Pharmacological Actions : Anticarcinogenic Agents, Cell cycle arrest, Chemopreventive

[+]

Lignans extracted from Vitex negundo possess cytotoxic activity by G2/M phase cell cycle arrest and apoptosis induction.May 14, 2013

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2013 May 15 ;20(7):640-7. Epub 2013 Apr 3. PMID: 23562365

Article Published Date : May 14, 2013

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Vitex negundo

Diseases : Breast Cancer: Triple Negative , Liver Cancer

Pharmacological Actions : Apoptotic, Cell cycle arrest

[+]

Lignans from Opuntia ficus-indica seeds protect rat primary hepatocytes and HepG2 cells against ethanol-induced oxidative stress.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Biosci Biotechnol Biochem. 2017 Jan ;81(1):181-183. Epub 2016 Sep 22. PMID: 27885940

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Prickly Pear Cactus

Diseases : Alcohol Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective

[+]

Lignans from sandalwood (Santalum album) exhibit cytotoxicity to various cancer cells.Jan 01, 2010

Click here to read the entire abstract

Pubmed Data : Chem Pharm Bull (Tokyo). 2010;58(4):587-90. PMID: 20410650

Article Published Date : Jan 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Sandalwood

Diseases : Leukemia, Lung Cancer, Promyelocytic leukemia

Pharmacological Actions : Apoptotic

[+]

Lignans from the seeds of Chinese hawthorn against β-amyloid aggregation.Jun 30, 2018

Click here to read the entire abstract

Pubmed Data : Nat Prod Res. 2018 Jul ;32(14):1706-1713. Epub 2017 Nov 8. PMID: 29115158

Article Published Date : Jun 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Hawthorn, Lignans

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Lignans with neuroprotective activity from the fruits of Crataegus pinnatifida.May 11, 2022

Click here to read the entire abstract

Pubmed Data : Fitoterapia. 2022 May 12:105216. Epub 2022 May 12. PMID: 35569638

Article Published Date : May 11, 2022

Study Type : In Vitro Study

Additional Links

Substances : Hawthorn, Lignans

Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress

Pharmacological Actions : Neuroprotective Agents

[+]

Lignin-derived oak phenolics, although found in small concentrations, may contribute to the beneficial antioxidant, chemopreventive, and cardioprotective effects of red wine.Nov 16, 2010

Click here to read the entire abstract

Pubmed Data : J Mol Model. 2010 Nov 16. Epub 2010 Nov 16. PMID: 21080014

Article Published Date : Nov 16, 2010

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Oak, Polyphenols, Red Wine Extract, Wine

Diseases : Cancers: All, Cardiovascular Diseases

Pharmacological Actions : Chemopreventive

[+]

Mammalian lignans and the soy isoflavone genistein inhibit breast cancer via down-regulation of estrogen production. Apr 01, 2005

Click here to read the entire abstract

Pubmed Data : J Steroid Biochem Mol Biol. 2005 Apr;94(5):461-7. Epub 2005 Mar 16. PMID: 15876411

Article Published Date : Apr 01, 2005

Study Type : In Vitro Study

Additional Links

Substances : Enterodiol, Enterolactone, Genistein, Lignans

Diseases : Breast Cancer, Estrogen Dominance

Pharmacological Actions : Aromatase Inhibitors

[+]

Mammalian lignans formed as a byproduct of flaxseed consumption inhibit prostate cancer cell growth. Nov 01, 2001

Click here to read the entire abstract

Pubmed Data : Anticancer Res. 2001 Nov-Dec;21(6A):3995-9. PMID: 11911282

Article Published Date : Nov 01, 2001

Study Type : In Vitro Study

Additional Links

Substances : Enterodiol, Enterolactone, Flaxseed, Lignans

Diseases : Prostate Cancer

Pharmacological Actions : Anticarcinogenic Agents

[+]

Mammalian lignans inhibit the growth of estrogen-independent human colon tumor cells.May 01, 1998

Click here to read the entire abstract

Pubmed Data : Anticancer Res. 1998 May-Jun;18(3A):1405-8. PMID: 9673348

Article Published Date : May 01, 1998

Study Type : In Vitro Study

Additional Links

Substances : Enterodiol, Enterolactone, Flaxseed, Lignans

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative

[+]

Natural lignans from Arctium lappa modulate P-glycoprotein efflux function in multidrug resistant cancer cells.Feb 14, 2015

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2015 Feb 15 ;22(2):301-7. Epub 2015 Jan 2. PMID: 25765837

Article Published Date : Feb 14, 2015

Study Type : In Vitro Study

Additional Links

Substances : Burdock, Lignans

Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Colon Cancer

Pharmacological Actions : Chemosensitizer, Multidrug Resistance Gene Modulators

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

[+]

Schisandra contains compounds which protect against hypoxia/reoxygenation-induced cell death in cardiomyocytes. May 23, 2008

Click here to read the entire abstract

Pubmed Data : Life Sci. 2008 May 23;82(21-22):1092-101. Epub 2008 Mar 30. PMID: 18452952

Article Published Date : May 23, 2008

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Schisandra

Diseases : Hypoxia, Myocardial Ischemia

Pharmacological Actions : Anti-Apoptotic, Cardioprotective

[+]

Schisandrol B protects against cholestatic liver injury through pregnane X receptors.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Br J Pharmacol. 2017 04 ;174(8):672-688. Epub 2017 Mar 16. PMID: 28128437

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Schisandra

Diseases : Cholestasis, Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Sesame seed oil does not contain significant quantities of sesamol. Sep 01, 1987

Click here to read the entire abstract

Pubmed Data : Contact Dermatitis. 1987 Sep ;17(3):133-5. PMID: 3677654

Article Published Date : Sep 01, 1987

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Sesamol

[+]

Sesamin catechol glucuronides exert anti-inflammatory effects.Jul 09, 2019

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2019 Jul 10 ;67(27):7640-7649. Epub 2019 Apr 16. PMID: 30951310

Article Published Date : Jul 09, 2019

Study Type : In Vitro Study

Additional Links

Substances : Catechols, Lignans, Sesame Seeds

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Sesamin may be a potential chemotherapy drug for liver cancer treatment. Dec 31, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biol Pharm Bull. 2013 ;36(10):1540-8. PMID: 24088253

Article Published Date : Dec 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Sesame Seeds, Sesamin

Diseases : Liver Cancer, Liver Cancer: Prevention

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Interleukin-6 Downregulation, STAT3 Inhibitor, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Seven new neuroprotective sesquineolignans isolated from the seeds of Crataegus pinnatifida.Feb 28, 2019

Click here to read the entire abstract

Pubmed Data : Fitoterapia. 2019 Mar ;133:225-230. Epub 2019 Jan 17. PMID: 30660653

Article Published Date : Feb 28, 2019

Study Type : In Vitro Study

Additional Links

Substances : Lignans

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

The mammalian phytoestrogens enterodiol and enterolactone may protect against breast and prostate cancer through hormone modulating activities.Sep 25, 2002

Click here to read the entire abstract

Pubmed Data : J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Sep 25;777(1-2):289-309. PMID: 12270221

Article Published Date : Sep 25, 2002

Study Type : Review

Additional Links

Substances : Enterodiol, Enterolactone, Flaxseed, Lignans, phytoestrogens, Secoisolariciresinol diglucoside (SDG)

Diseases : Breast Cancer, Cancers: All, Prostate Cancer

Pharmacological Actions : Aromatase Inhibitors

[+]

The relationship of antioxidant components and antioxidant activity of sesame seed oil.Sep 30, 2015

Click here to read the entire abstract

Pubmed Data : J Sci Food Agric. 2015 Oct ;95(13):2571-8. Epub 2015 Jan 23. PMID: 25472416

Article Published Date : Sep 30, 2015

Study Type : Review

Additional Links

Substances : Lignans, Sesame Seed Oil

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

The therapeutic potential of arctigenin against multiple human diseases: A mechanistic review.Jan 31, 2023

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2023 Feb ;110:154647. Epub 2023 Jan 2. PMID: 36628833

Article Published Date : Jan 31, 2023

Study Type : Review

Additional Links

Substances : Lignans

Diseases : Chronic Disease, Hepatic Steatosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Nrf2 activation

[+]

These results suggest that sesamolin induces apoptosis in HCT116 cells.Jul 30, 2019

Click here to read the entire abstract

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2019 Jul 31 ;65(6):96-100. Epub 2019 Jul 31. PMID: 31472054

Article Published Date : Jul 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Sesame Seeds

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Interleukin-6 Downregulation, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, STAT3 Inhibitor

[+]

Tyrosinase inhibitory lignans from the methanol extract of the roots of Vitex negundo Linn. and their structure-activity relationship.Feb 28, 2006

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2006 Mar ;13(4):255-60. Epub 2005 Jun 27. PMID: 16492528

Article Published Date : Feb 28, 2006

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Vitex negundo

Pharmacological Actions : Tyrosinase Inhibition

Additional Keywords : Plant Extracts

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Sesamin can be used as an obtainable dietary supplement to improve blood pressure and blood lipids.Dec 31, 2021

A flaxseed-derived lignan supplement has therapeutic value in type 2 diabetics. Nov 07, 2007

A lignan rich diet reduces body mass index, abdominal fat and insulin resistance in post-menopausal women. Sep 01, 2001

Antihypertensive effects of sesamin in humansJan 31, 2009

Flaxseed consumption was associated with a longer luteal phase and a higher luteal phase progesterone-to-estradiol ratio.Nov 01, 1993

Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men.Jun 30, 2010

Flaxseed may reduce circulating total and LDL-cholesterol levels.Aug 01, 2009

Flaxseed meal and flaxseed extract is effective in reducing menopausal symptoms without increasing blood levels of follicle stimulating hormone and estradiol, as well as in the endometrial thickness, and vaginal epithelial maturation value.Aug 31, 2012

Flaxseed modulates inflammatory and oxidative stress biomarkers in cystic fibrosis.May 12, 2015

Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer.Mar 31, 2013

Greater consumption of total and individual lignans and dietary fibers were significantly associated with lowered risk of hip fracture.Mar 04, 2022

High dietary intakes of plant lignans and high exposure to enterolignans were associated with reduced risks of ER- and PR-positive postmenopausal breast cancer. Mar 21, 2007

Lignan content of the flaxseed influences its biological effects in healthy men and women.May 31, 2013

lignan phytoestrogens may have a protective effect against incontinence in postmenopausal women.Sep 30, 2015

Long-term flaxseed lignan-enriched complex supplementation in older adults has an ability to favourably modulate systolic blood pressure.Oct 31, 2017

Pine cone lignin and ascorbic acid combination has a potent antiviral activity, promoting faster healing, reduction of symptoms and reducing the frequency of recurrence episodes in HSV-1.Oct 31, 2009

Rheumatoid patients subjectively benefited from the vegan diet rich in antioxidants, lactobacilli and fibre.Nov 29, 2000

Sesame lignans with vitamin E supplementation could safely alleviate daily fatigue and oxidative stress.Mar 24, 2015

The results of the present study indicate that a dietary pattern characterised by the intake of lignans, quercetin and resveratrol may play a protective role in the development of oesophageal cancersNov 30, 2014

There is a modest inverse association between lignan excretion and uterine fibroid risk. Jan 01, 2005

Arctigenin attenuates ischemia/reperfusion induced ventricular arrhythmias.Dec 31, 2017

Dietary flaxseed may be chemopreventive for intestinal and colon tumor development in mice possibly by increasing omega -3 fatty acid levels, lignans, and decreasing COX-1 and COX-2 levels.Jan 01, 2009

Dietary flaxseed meal containing high levels of omega-3 fatty acids and lignans is effective in preventing colon tumor development when compared with dietary corn meal possibly by increasing omega-3 fatty acid levels and decreasing COX-1 and COX-2 levels.Jan 01, 2006

Dietary phytochemicals have a beneficial effect on benign prostatic hyperplasia prevention.Nov 30, 2016

Enterolactone and enterodiol have been shown to negate the tumor-stimulating effect of genistein in a mouse model of breast cancer.Jul 01, 2007

Flaxseed and its lignans have potent antiestrogenic effects on estrogen receptor-positive breast cancer and may prove to be beneficial in breast cancer prevention strategies in the future.Feb 01, 2007

Flaxseed has radioprotective properties against lung injury. Oct 28, 2012

Flaxseed lignan attenuates high-fat diet-induced visceral and liver fat accumulation and induces adiponectin expression in mice.Sep 01, 2008

Lig-8, a bioactive lignophenol derivative from bamboo lignin, protects against neuronal damage in vitro and in vivo.Oct 01, 2006

Lignan transformation by gut bacteria lowers tumor burden in a gnotobiotic rat model of breast cancer.Dec 31, 2011

Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans.Aug 31, 2015

Pharmacological effects of natural components against ovarian cancer and mechanisms.Dec 31, 2020

Protective effects of gomisin A isolated from Schisandra chinensis against CCl(4)-induced hepatic and renal injury.Mar 31, 2013

Protective role of flaxseed oil and flaxseed lignan secoisolariciresinol diglucoside against oxidative stress in rats with metabolic syndrome.Nov 30, 2017

Rye lignan reduces estradiol-induced uterine growth.Aug 01, 2009

Schisandrol B promotes liver regeneration after partial hepatectomy in mice.Jan 04, 2018

Secoisolariciresinol diglucoside is effective in slowing the progression of atherosclerosis and partially effective in regression of hypercholesterolemic atherosclerosis.Dec 01, 2010

Sesame extract may be effective in preventing abdominal aortic aneurysm development.Dec 31, 2018

Sesame lignans inhibit delta-5 desaturase activity, increasing dihomo-gamma-linoleic acid levels and decreasing prostaglandin E2 synthesis.Mar 01, 1998

Sesame lignans suppress age-related cognitive decline in senescence-accelerated mice.Jul 11, 2019

Sesamin alleviates asthma airway inflammation by regulating mitophagy and mitochondrial apoptosis.Apr 26, 2022

Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats.Jan 05, 2010

Sesamin lignan reduced the growth of human breast tumors at high levels of circulating estrogen in athymic mice.Dec 31, 2011

Sesamin may prevent the development of atherosclerosis and inflammatory responsesSep 01, 2010

Soy and rye diets have an inhibitory effect on the development of prostate cancer in rats.Jan 01, 2008

Targeted lignan profiling and anti-inflammatory properties of Schisandra rubriflora and Schisandra chinensis extracts.Nov 26, 2018

The lignan precursor from flaxseed known as secoisolariresinol diglucoside (SDG) may inhibit the progression of lupus nephritis. Jan 01, 2000

Therapeutic effects of standardized Vitex negundo seeds extract on complete Freund's adjuvant induced arthritis.May 14, 2014

These results suggest that gomisin A protects the liver from injury after administration of acetaminophen through the suppression of lipid peroxidation.Sep 13, 1993

Treatment with SDG normalized several biomarkers in mammary gland tissue, dysplasia, cell number, and expression of several genes that had been altered by carcinogen.May 25, 2015

Turmeric and curcumin reverse aflatoxin-induced liver damage.Aug 01, 1992

Sesamolin promotes cytolysis and migration activity of natural killer cells via dendritic cells.Mar 31, 2020

A hot-water extract of I. obliquus had anti-tumor activities. Feb 28, 2015

An extract from schisandra chinensis berries inhibited the growth of both C. pneumoniae and C. trachomatis.May 31, 2015

Anti-HIV-1 activity of lignans from the fruits of Schisandra rubriflora.Apr 30, 2010

Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells.Oct 14, 2013

Antioxidant lignans from the seeds of Vitex negundoDec 31, 2013

Arctigenin exerts neuroprotective effect by ameliorating cortical activities in experimental autoimmune encephalomyelitis.Dec 31, 2020

Comparative effects of sesame lignans (sesamin, sesamolin, and sesamol) on oxidative stress and lipid metabolism in steatosis HepG2 cells.Apr 08, 2022

Curcumin exhibits estrogen-like activity.Jan 01, 2010

Dibenzocyclooctadiene lignans from the fruits of Schisandra rubriflora and their anti-HIV-1 activities.Apr 30, 2011

Dietary lignans reduce breask cancer risk. Jul 01, 2007

Enterolactone suppresses lung cancer cell motility and invasion by altering FAK activity.Jan 08, 2017

Flaxseed lignans enhance the cytotoxicity of chemotherapeutic agents against breast cancer cell lines MDA-MB-231 and SKBR3.Jan 31, 2018

Gomisin A inhibits lipopolysaccharide-induced inflammatory responses in N9 microglia.Dec 31, 2013

Gomisin A modulates aging progress via mitochondrial biogenesis in human diploid fibroblast cells.Dec 31, 2017

Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3.Sep 04, 2018

Honokiol: An anticancer lignan.Oct 31, 2018

Identification of methanol-soluble compounds in sesame and evaluation of antioxidant potential of its lignans.Apr 13, 2011

JWH-015, THC, CBD, Abn-CBD and O-1602 all protected SH-SY5Y cells from BV-2 conditioned media activated via LPS.Dec 31, 2013

Lignans and flavonoids act as aromatase inhibitors in human preadipocytes. Aug 01, 1994

Lignans are involved in the antitumor activity of wheat bran in colon cancer cells.Mar 01, 2005

Lignans

View the Evidence:
93 Abstracts with Lignans Research