Lignans

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56 Diseases Researched for Lignans
NameACCKFocus
Breast Cancer926Locked
High Cholesterol220Locked
Breast Cancer: Prevention415Locked
Prostate Cancer415Locked
Abdominal Obesity (Midsection Fat)214Locked
Oxidative Stress312Locked
Cholesterol: LDL/HDL ratio110Locked
Cholesterol: Oxidation110Locked
Chronic Fatigue Syndrome110Locked
Diabetes Mellitus: Type 2110Locked
Esophageal Cancer110Locked
Fatigue110Locked
Fibroids: Uterine110Locked
Herpes Simplex Virus Type 1110Locked
Hot Flash110Locked
Incontinence110Locked
Inflammation110Locked
Insulin Resistance110Locked
Menopausal Syndrome110Locked
Prostate Cancer: Prevention110Locked
Rheumatoid Arthritis110Locked
Colon Cancer57Locked
Adiponectin: Low Levels14Locked
Atherosclerosis24Locked
Cancers: All34Locked
Estrogen Dominance34Locked
Fatty Liver14Locked
Lupus Nephritis14Locked
Aflatoxicosis12Locked
Brain Damage12Locked
Breast Cancer: Chemically-Induced12Locked
Endothelial Dysfunction12Locked
Intestinal Cancer12Locked
Liver Damage: Aflatoxin-Induced12Locked
Lung Cancer22Locked
Middle Cerebral Artery Occlusion (MCAO)12Locked
Neurodegenerative Diseases12Locked
Prostatic Hyperplasia: Benign12Locked
Radiation-induced illness: Lung12Locked
Uterine Cancer 12Locked
Brain: Microglial Activation11Locked
Cancer Metastasis11Locked
Cancers: Drug Resistant11Locked
Cancers: Multi-Drug Resistant11Locked
Cardiovascular Diseases11Locked
Chlamydia pneumoniae 11Locked
Chlamydia trachomatis11Locked
Estrogen Deficiency11Locked
Hypoxia11Locked
Leukemia11Locked
Lipopolysaccharide-Induced Toxicity11Locked
Liver Cancer11Locked
Liver Cancer: Prevention11Locked
Myocardial Ischemia11Locked
Pneumonia11Locked
Promyelocytic leukemia 11Locked
36 Pharmacological Actions Researched for Lignans
NameACCKFocus
Antioxidants837Locked
Antiproliferative 923Locked
Anticarcinogenic Agents516Locked
Chemopreventive616Locked
Vascular Endothelial Growth Factor A Inhibitor212Locked
Anticholesteremic Agents211Locked
Anti-Infective Agents110Locked
Antiviral Agents110Locked
Apoptotic46Locked
Cell cycle arrest45Locked
Neuroprotective Agents35Locked
Anti-Adipogenic14Locked
Antineoplastic Agents24Locked
Aromatase Inhibitors34Locked
Cyclooxygenase 1 Inhibitor24Locked
Cyclooxygenase 2 Inhibitors24Locked
Superoxide Dismutase Up-regulation14Locked
Cardioprotective23Locked
Tumor Suppressor Protein p53 Upregulation23Locked
Anti-Inflammatory Agents12Locked
Cyclin D1 Down-Regulation12Locked
Cyclooxygenase Inhibitors12Locked
Hepatoprotective12Locked
Proteasome Inhibitors12Locked
Radioprotective12Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor12Locked
Anti-Apoptotic11Locked
Anti-Bacterial Agents11Locked
Anti-metastatic11Locked
Antimicrobial11Locked
Chemosensitizer11Locked
Estrogen Receptor Modulators11Locked
Interleukin-6 Downregulation11Locked
Multidrug Resistance Gene Modulators11Locked
NF-kappaB Inhibitor11Locked
STAT3 Inhibitor11Locked

View the Evidence:
82 Abstracts with Lignans Research

[+]

A flaxseed-derived lignan supplement has therapeutic value in type 2 diabetics. Nov 07, 2007

Pubmed Data : PLoS One. 2007 Nov 7;2(11):e1148. PMID: 17987126
Article Published Date : Nov 07, 2007
Study Type : Human Study
Additional Links
Substances : Flaxseed, Lignans
Diseases : Diabetes Mellitus: Type 2
[+]

A lignan rich diet reduces body mass index, abdominal fat and insulin resistance in post-menopausal women. Sep 01, 2001

Pubmed Data : Mutat Res. 2001 Sep 1;480-481:201-7. PMID: 19586570
Article Published Date : Sep 01, 2001
Study Type : Human Study
Additional Links
Substances : Lignans
Diseases : Abdominal Obesity (Midsection Fat), Insulin Resistance
[+]

Flaxseed consumption was associated with a longer luteal phase and a higher luteal phase progesterone-to-estradiol ratio.Nov 01, 1993

Pubmed Data : J Clin Endocrinol Metab. 1993 Nov ;77(5):1215-9. PMID: 8077314
Article Published Date : Nov 01, 1993
Study Type : Human Study
Additional Links
Substances : Lignans
Diseases : Hormone Imbalances
[+]

Flaxseed may reduce circulating total and LDL-cholesterol levels.Aug 01, 2009

Pubmed Data : Am J Clin Nutr. 2009 Aug;90(2):288-97. Epub 2009 Jun 10. PMID: 19515737
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Substances : Flaxseed, Lignans
Diseases : Cholesterol: LDL/HDL ratio, High Cholesterol
Pharmacological Actions : Anticholesteremic Agents
[+]

Flaxseed meal and flaxseed extract is effective in reducing menopausal symptoms without increasing blood levels of follicle stimulating hormone and estradiol, as well as in the endometrial thickness, and vaginal epithelial maturation value.Aug 31, 2012

Pubmed Data : J Med Food. 2012 Sep ;15(9):840-5. PMID: 22925074
Article Published Date : Aug 31, 2012
Study Type : Human Study
Additional Links
Substances : Flaxseed, Secoisolariciresinol diglucoside (SDG)
Diseases : Hot Flash, Menopausal Syndrome
[+]

Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer.Mar 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Food. 2013 Apr ;16(4):357-60. PMID: 23566060
Article Published Date : Mar 31, 2013
Study Type : Human Study
Additional Links
Substances : Enterolactone, Flaxseed, Lignans
Diseases : Prostate Cancer, Prostate Cancer: Prevention
Pharmacological Actions : Antiproliferative , Chemopreventive, Vascular Endothelial Growth Factor A Inhibitor
Additional Keywords : Phytotherapy, Plant Extracts
[+]

High dietary intakes of plant lignans and high exposure to enterolignans were associated with reduced risks of ER- and PR-positive postmenopausal breast cancer. Mar 21, 2007

Pubmed Data : J Natl Cancer Inst. 2007 Mar 21;99(6):475-86. PMID: 17374837
Article Published Date : Mar 21, 2007
Study Type : Human Study
Additional Links
Substances : Enterodiol, Enterolactone, Flaxseed, Lignans, phytoestrogens
Diseases : Breast Cancer, Breast Cancer: Prevention
Additional Keywords : Risk Reduction
[+]

Lignan content of the flaxseed influences its biological effects in healthy men and women.May 31, 2013

Pubmed Data : J Am Coll Nutr. 2013 Jun ;32(3):194-9. PMID: 23885993
Article Published Date : May 31, 2013
Study Type : Human Study
Additional Links
Substances : Flaxseed, Lignans
Diseases : Cholesterol: Oxidation, High Cholesterol
[+]

lignan phytoestrogens may have a protective effect against incontinence in postmenopausal women.Sep 30, 2015

Pubmed Data : Urology. 2015 Oct ;86(4):716-20. Epub 2015 Jul 29. PMID: 26232691
Article Published Date : Sep 30, 2015
Study Type : Human Study
Additional Links
Substances : Lignans
Diseases : Incontinence
Additional Keywords : Risk Reduction
[+]

Long-term flaxseed lignan-enriched complex supplementation in older adults has an ability to favourably modulate systolic blood pressure.Oct 31, 2017

Pubmed Data : J Am Coll Nutr. 2017 Nov-Dec;36(8):646-653. Epub 2017 Sep 18. PMID: 28922068
Article Published Date : Oct 31, 2017
Study Type : Human Study
Additional Links
Substances : Flaxseed, Lignans
Diseases : Cardiovascular Diseases, Hypertension, Inflammation
Pharmacological Actions : Antihypertensive Agents
Additional Keywords : Risk Reduction
[+]

Pine cone lignin and ascorbic acid combination has a potent antiviral activity, promoting faster healing, reduction of symptoms and reducing the frequency of recurrence episodes in HSV-1.Oct 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : In Vivo. 2009 Nov-Dec;23(6):1011-6. PMID: 20023248
Article Published Date : Oct 31, 2009
Study Type : Human Study
Additional Links
Substances : Lignans, Pine Cone, Vitamin C
Diseases : Herpes Simplex Virus Type 1
Pharmacological Actions : Anti-Infective Agents, Antiviral Agents
Additional Keywords : Natural Substance Synergy, Plant Extracts, Recurrence Risk, Significant Treatment Outcome
[+]

Rheumatoid patients subjectively benefited from the vegan diet rich in antioxidants, lactobacilli and fibre.Nov 29, 2000

Pubmed Data : Toxicology. 2000 Nov 30 ;155(1-3):45-53. PMID: 11156742
Article Published Date : Nov 29, 2000
Study Type : Human Study
Additional Links
Substances : Carotenoids, Fiber, Flavonoids, Lignans
Diseases : Inflammation, Rheumatoid Arthritis
Therapeutic Actions : Dietary Modification: Vegetarian
Pharmacological Actions : Antioxidants
[+]

Sesame lignans with vitamin E supplementation could safely alleviate daily fatigue and oxidative stress.Mar 24, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Glob J Health Sci. 2015 Mar 25 ;7(6):1-10. Epub 2015 Mar 25. PMID: 26153159
Article Published Date : Mar 24, 2015
Study Type : Human Study
Additional Links
Substances : Lignans, Sesame Seeds
Diseases : Chronic Fatigue Syndrome, Fatigue, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

The results of the present study indicate that a dietary pattern characterised by the intake of lignans, quercetin and resveratrol may play a protective role in the development of oesophageal cancersNov 30, 2014

Pubmed Data : Br J Nutr. 2014 Dec ;112(12):2002-9. Epub 2014 Oct 27. PMID: 25345471
Article Published Date : Nov 30, 2014
Study Type : Human Study
Additional Links
Substances : Lignans, Quercetin, Resveratrol
Diseases : Esophageal Cancer
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Dietary Modification, Natural Substance Synergy, Plant Extracts
[+]

There is a modest inverse association between lignan excretion and uterine fibroid risk. Jan 01, 2005

Pubmed Data : Cytotechnology. 2005 Jan;47(1-3):97-105. PMID: 16960173
Article Published Date : Jan 01, 2005
Study Type : Human Study
Additional Links
Substances : Daidzein, Enterodiol, Enterolactone, Equol, Genistein, Isoflavones, Lignans
Diseases : Fibroids: Uterine
[+]

Arctigenin attenuates ischemia/reperfusion induced ventricular arrhythmias.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;49(2):728-742. Epub 2018 Aug 30. PMID: 30165360
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Lignans
Diseases : Myocardial Infarction, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
[+]

Dietary flaxseed may be chemopreventive for intestinal and colon tumor development in mice possibly by increasing omega -3 fatty acid levels, lignans, and decreasing COX-1 and COX-2 levels.Jan 01, 2009

Pubmed Data : Nutr Cancer. 2009;61(2):276-83. PMID: 19235044
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Flaxseed, Lignans, Omega-3 Fatty Acids
Diseases : Colon Cancer, Intestinal Cancer
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
[+]

Dietary flaxseed meal containing high levels of omega-3 fatty acids and lignans is effective in preventing colon tumor development when compared with dietary corn meal possibly by increasing omega-3 fatty acid levels and decreasing COX-1 and COX-2 levels.Jan 01, 2006

Pubmed Data : Nutr Cancer. 2006;54(2):216-22. PMID: 16898866
Article Published Date : Jan 01, 2006
Study Type : Animal Study
Additional Links
Substances : Flaxseed, Lignans, Omega-3 Fatty Acids
Diseases : Colon Cancer
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Dietary phytochemicals have a beneficial effect on benign prostatic hyperplasia prevention.Nov 30, 2016

Pubmed Data : Appl Physiol Nutr Metab. 2016 Dec ;41(12):1303-1310. Epub 2016 Sep 27. PMID: 27849354
Article Published Date : Nov 30, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flaxseed, Lignans
Diseases : Prostatic Hyperplasia: Benign
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation, Tumor Suppressor Protein p53 Upregulation
[+]

Enterolactone and enterodiol have been shown to negate the tumor-stimulating effect of genistein in a mouse model of breast cancer.Jul 01, 2007

Pubmed Data : Mol Nutr Food Res. 2007 Jul;51(7):845-56. PMID: 17579892
Article Published Date : Jul 01, 2007
Study Type : Animal Study
Additional Links
Substances : Enterodiol, Enterolactone, Flaxseed, Genistein, Isoflavones, Lignans, phytoestrogens, Soy Protein
Diseases : Breast Cancer, Breast Cancer: Prevention
Pharmacological Actions : Antineoplastic Agents, Antiproliferative
[+]

Flaxseed and its lignans have potent antiestrogenic effects on estrogen receptor-positive breast cancer and may prove to be beneficial in breast cancer prevention strategies in the future.Feb 01, 2007

Pubmed Data : Clin Cancer Res. 2007 Feb 1;13(3):1061-7. PMID: 17289903
Article Published Date : Feb 01, 2007
Study Type : Animal Study
Additional Links
Substances : Enterodiol, Enterolactone, Flaxseed, Lignans
Diseases : Breast Cancer, Breast Cancer: Prevention
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Vascular Endothelial Growth Factor A Inhibitor
[+]

Flaxseed has radioprotective properties against lung injury. Oct 28, 2012

Pubmed Data : Radiat Res. 2012 Oct 29. Epub 2012 Oct 29. PMID: 23106213
Article Published Date : Oct 28, 2012
Study Type : Animal Study
Additional Links
Substances : Flaxseed, Secoisolariciresinol diglucoside (SDG)
Diseases : Radiation-induced illness: Lung
Pharmacological Actions : Radioprotective
[+]

Flaxseed lignan attenuates high-fat diet-induced visceral and liver fat accumulation and induces adiponectin expression in mice.Sep 01, 2008

Pubmed Data : Br J Nutr. 2008 Sep;100(3):669-76. Epub 2008 Feb 6. PMID: 18252024
Article Published Date : Sep 01, 2008
Study Type : Animal Study
Additional Links
Substances : Enterodiol, Flaxseed, Lignans, Secoisolariciresinol diglucoside (SDG)
Diseases : Abdominal Obesity (Midsection Fat), Adiponectin: Low Levels, Fatty Liver
Pharmacological Actions : Anti-Adipogenic
[+]

Lig-8, a bioactive lignophenol derivative from bamboo lignin, protects against neuronal damage in vitro and in vivo.Oct 01, 2006

Pubmed Data : J Pharmacol Sci. 2006 Oct;102(2):196-204. Epub 2006 Oct 7. PMID: 17031070
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Substances : Bamboo, Lignans
Diseases : Brain Damage, Neurodegenerative Diseases
Pharmacological Actions : Apoptotic, Neuroprotective Agents, Proteasome Inhibitors
[+]

Lignan transformation by gut bacteria lowers tumor burden in a gnotobiotic rat model of breast cancer.Dec 31, 2011

Pubmed Data : Carcinogenesis. 2012 Jan ;33(1):203-8. Epub 2011 Nov 10. PMID: 22080573
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Lignan-converting bacteria , Lignans, Secoisolariciresinol diglucoside (SDG)
Diseases : Breast Cancer
Pharmacological Actions : Superoxide Dismutase Up-regulation
Additional Keywords : Bacterial Biotransformation
[+]

Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans.Aug 31, 2015

Pubmed Data : Phytochemistry. 2015 Sep ;117:340-350. Epub 2015 Jul 1. PMID: 26141518
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Burdock, Lignans
Diseases : Aging, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Protective effects of gomisin A isolated from Schisandra chinensis against CCl(4)-induced hepatic and renal injury.Mar 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2013 Apr ;31(4):888-98. Epub 2013 Jan 31. PMID: 23381504
Article Published Date : Mar 31, 2013
Study Type : Animal Study
Additional Links
Substances : Lignans, Schisandra
Diseases : Chemically-Induced Liver Damage, Kidney Damage: Chemically-Induced
Pharmacological Actions : Hepatoprotective, Renoprotective
[+]

Protective role of flaxseed oil and flaxseed lignan secoisolariciresinol diglucoside against oxidative stress in rats with metabolic syndrome.Nov 30, 2017

Pubmed Data : J Food Sci. 2017 Dec ;82(12):3029-3036. Epub 2017 Oct 30. PMID: 29083494
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Flaxseed, Lignans
Diseases : Metabolic Syndrome X, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Rye lignan reduces estradiol-induced uterine growth.Aug 01, 2009

Pubmed Data : Mol Nutr Food Res. 2009 Aug;53(8):996-1006. PMID: 19603405
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Substances : Isoflavones, Lignans, Rye
Diseases : Estrogen Dominance, Uterine Cancer
[+]

Schisandrol B promotes liver regeneration after partial hepatectomy in mice.Jan 04, 2018

Pubmed Data : Eur J Pharmacol. 2018 Jan 5 ;818:96-102. Epub 2017 Oct 21. PMID: 29066412
Article Published Date : Jan 04, 2018
Study Type : Animal Study
Additional Links
Substances : Lignans, Schisandra
Diseases : Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Liver Regeneration
[+]

Secoisolariciresinol diglucoside is effective in slowing the progression of atherosclerosis and partially effective in regression of hypercholesterolemic atherosclerosis.Dec 01, 2010

Pubmed Data : Curr Pharm Biotechnol. 2010 Dec;11(8):794-800. PMID: 20874684
Article Published Date : Dec 01, 2010
Study Type : Animal Study
Additional Links
Substances : Flaxseed, Secoisolariciresinol diglucoside (SDG)
Diseases : Atherosclerosis
Pharmacological Actions : Cardioprotective
Additional Keywords : Disease Regression
[+]

Sesame extract may be effective in preventing abdominal aortic aneurysm development.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Oleo Sci. 2019 ;68(1):79-85. PMID: 30606956
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Lignans
Diseases : Aortic Aneurysm, Nicotine/Tobacco Toxicity
Pharmacological Actions : Antioxidants, Matrix Metalloproteinase-12 (MMP-12) Inhibitor
Additional Keywords : Plant Extracts
[+]

Sesame lignans inhibit delta-5 desaturase activity, increasing dihomo-gamma-linoleic acid levels and decreasing prostaglandin E2 synthesis.Mar 01, 1998

Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 1998 Mar ;58(3):185-91. PMID: 9610840
Article Published Date : Mar 01, 1998
Study Type : Animal Study
Additional Links
Substances : Lignans
Pharmacological Actions : Prostaglandin PGE2 downregulation
Additional Keywords : Anti-Inflammatory Agents, arachidonic acid, Gamma-Linoleic Acid GLA, Inflammation, Prostaglandin E2
[+]

Sesame lignans suppress age-related cognitive decline in senescence-accelerated mice.Jul 11, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Jul 12 ;11(7). Epub 2019 Jul 12. PMID: 31336975
Article Published Date : Jul 11, 2019
Study Type : Animal Study
Additional Links
Substances : Lignans, Sesame Seeds
Diseases : Cognitive Decline/Dysfunction
Pharmacological Actions : Neuroprotective Agents
[+]

Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats.Jan 05, 2010

Pubmed Data : Chem Biol Interact. 2010 Jan 5;183(1):255-63. PMID: 19835851
Article Published Date : Jan 05, 2010
Study Type : Animal Study
Additional Links
Substances : Lignans
Diseases : Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Sesamin lignan reduced the growth of human breast tumors at high levels of circulating estrogen in athymic mice.Dec 31, 2011

Pubmed Data : Nutr Cancer. 2012 ;64(1):65-71. Epub 2011 Dec 2. PMID: 22136581
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Lignans, Sesamin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Sesamin may prevent the development of atherosclerosis and inflammatory responsesSep 01, 2010

Pubmed Data : Mol Nutr Food Res. 2010 Sep ;54(9):1340-50. PMID: 20306475
Article Published Date : Sep 01, 2010
Study Type : Animal Study
Additional Links
Substances : Lignans, Sesamol
Diseases : Atherosclerosis, Endothelial Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Soy and rye diets have an inhibitory effect on the development of prostate cancer in rats.Jan 01, 2008

Pubmed Data : Med Princ Pract. 2008;17(2):131-5. Epub 2008 Feb 19. PMID: 9687986
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Lignans, phytoestrogens, Rye, Soy Protein
Diseases : Prostate Cancer
Pharmacological Actions : Chemopreventive
[+]

Targeted lignan profiling and anti-inflammatory properties of Schisandra rubriflora and Schisandra chinensis extracts.Nov 26, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Nov 27 ;23(12). Epub 2018 Nov 27. PMID: 30486445
Article Published Date : Nov 26, 2018
Study Type : Animal Study
Additional Links
Substances : Lignans, Schisandra
Diseases : Inflammation
Pharmacological Actions : 15-Lipoxygenase (15-LOX) Inhibitor, Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

The lignan precursor from flaxseed known as secoisolariresinol diglucoside (SDG) may inhibit the progression of lupus nephritis. Jan 01, 2000

Pubmed Data : Lupus. 2000;9(6):429-36. PMID: 10981647
Article Published Date : Jan 01, 2000
Study Type : Animal Study
Additional Links
Substances : Enterodiol, Enterolactone, Flaxseed, Lignans, Secoisolariciresinol diglucoside (SDG)
Diseases : Lupus Nephritis
[+]

Therapeutic effects of standardized Vitex negundo seeds extract on complete Freund's adjuvant induced arthritis.May 14, 2014

Pubmed Data : Phytomedicine. 2014 May 15 ;21(6):838-46. Epub 2014 Mar 25. PMID: 24680620
Article Published Date : May 14, 2014
Study Type : Animal Study
Additional Links
Substances : Lignans, Vitex negundo
Diseases : Arthritis, Inflammation, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-10 upregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Phytotherapy, Plant Extracts
[+]

These results suggest that gomisin A protects the liver from injury after administration of acetaminophen through the suppression of lipid peroxidation.Sep 13, 1993

Pubmed Data : Biochem Pharmacol. 1993 Sep 14 ;46(6):1081-5. PMID: 8216352
Article Published Date : Sep 13, 1993
Study Type : Animal Study
Additional Links
Substances : Lignans, Schisandra
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Treatment with SDG normalized several biomarkers in mammary gland tissue, dysplasia, cell number, and expression of several genes that had been altered by carcinogen.May 25, 2015

Pubmed Data : Nutr Cancer. 2015 May 26:1-8. Epub 2015 May 26. PMID: 26010915
Article Published Date : May 25, 2015
Study Type : Animal Study
Additional Links
Substances : Flaxseed, Lignans
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative
Additional Keywords : Dietary Modification, Gene Expression Regulation
[+]

Turmeric and curcumin reverse aflatoxin-induced liver damage.Aug 01, 1992

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 1992 Aug;38(4):353-63. PMID: 1291640
Article Published Date : Aug 01, 1992
Study Type : Animal Study
Additional Links
Substances : Curcumin, Lignans
Diseases : Aflatoxicosis, Liver Damage: Aflatoxin-Induced
Pharmacological Actions : Hepatoprotective
[+]

Sesamolin promotes cytolysis and migration activity of natural killer cells via dendritic cells.Mar 31, 2020

Pubmed Data : Arch Pharm Res. 2020 Apr ;43(4):462-474. Epub 2020 Apr 11. PMID: 32279231
Article Published Date : Mar 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Sesame Seeds
Diseases : Cancers: All
Pharmacological Actions : Immunomodulatory
[+]

A hot-water extract of I. obliquus had anti-tumor activities. Feb 28, 2015

Pubmed Data : Int J Biol Macromol. 2015 Mar ;74:507-14. Epub 2015 Jan 10. PMID: 25583019
Article Published Date : Feb 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Chaga Mushroom (Inonotus obliquus), Lignans
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative , Cell cycle arrest, NF-kappaB Inhibitor
[+]

An extract from schisandra chinensis berries inhibited the growth of both C. pneumoniae and C. trachomatis.May 31, 2015

Pubmed Data : Nat Prod Commun. 2015 Jun ;10(6):1001-4. PMID: 26197536
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Schisandra
Diseases : Chlamydia pneumoniae , Chlamydia trachomatis, Pneumonia
Pharmacological Actions : Anti-Bacterial Agents, Antimicrobial
Additional Keywords : Dose Response, Plant Extracts
[+]

Anti-HIV-1 activity of lignans from the fruits of Schisandra rubriflora.Apr 30, 2010

Pubmed Data : Arch Pharm Res. 2010 May ;33(5):697-701. Epub 2010 May 29. PMID: 20512467
Article Published Date : Apr 30, 2010
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Schisandra
Diseases : HIV Infections
Pharmacological Actions : Anti-HIV Agents
[+]

Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells.Oct 14, 2013

Pubmed Data : Bioorg Med Chem Lett. 2013 Oct 15 ;23(20):5511-4. Epub 2013 Aug 22. PMID: 24018191
Article Published Date : Oct 14, 2013
Study Type : In Vitro Study
Additional Links
Substances : Honeysuckle, Lignans
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Wnt/β-catenin signaling pathway modulation
[+]

Antioxidant lignans from the seeds of Vitex negundoDec 31, 2013

Pubmed Data : J Asian Nat Prod Res. 2014 ;16(9):963-9. Epub 2014 Jun 26. PMID: 24965780
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Vitex negundo
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Curcumin exhibits estrogen-like activity.Jan 01, 2010

Pubmed Data : Cell Physiol Biochem. 2010;26(3):471-82. Epub 2010 Aug 24. PMID: 20798532
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Lignans, Quercetin
Diseases : Estrogen Deficiency
Pharmacological Actions : Estrogen Receptor Modulators
[+]

Dibenzocyclooctadiene lignans from the fruits of Schisandra rubriflora and their anti-HIV-1 activities.Apr 30, 2011

Pubmed Data : J Asian Nat Prod Res. 2011 May ;13(5):393-9. PMID: 21534036
Article Published Date : Apr 30, 2011
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Schisandra
Diseases : HIV Infections
Pharmacological Actions : Anti-HIV Agents
[+]

Dietary lignans reduce breask cancer risk. Jul 01, 2007

Pubmed Data : Mol Nutr Food Res. 2007 Jul;51(7):857-66. PMID: 17576639
Article Published Date : Jul 01, 2007
Study Type : Review
Additional Links
Substances : Enterodiol, Enterolactone, Lignans
Diseases : Breast Cancer: Prevention
Pharmacological Actions : Chemopreventive
[+]

Enterolactone suppresses lung cancer cell motility and invasion by altering FAK activity.Jan 08, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2017 Jan 9 ;17(1):30. Epub 2017 Jan 9. PMID: 28068967
Article Published Date : Jan 08, 2017
Study Type : In Vitro Study
Additional Links
Substances : Flaxseed, Lignans
Diseases : Cancer Metastasis, Lung Cancer
Pharmacological Actions : Anti-metastatic
Additional Keywords : gene express, Plant Extracts
[+]

Flaxseed lignans enhance the cytotoxicity of chemotherapeutic agents against breast cancer cell lines MDA-MB-231 and SKBR3.Jan 31, 2018

Pubmed Data : Nutr Cancer. 2018 Feb-Mar;70(2):306-315. Epub 2018 Jan 5. PMID: 29303360
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Flaxseed, Lignans
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
[+]

Gomisin A inhibits lipopolysaccharide-induced inflammatory responses in N9 microglia.Dec 31, 2013

Pubmed Data : Food Chem Toxicol. 2014 Jan ;63:119-27. Epub 2013 Nov 7. PMID: 24211520
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Schisandra
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Gomisin A modulates aging progress via mitochondrial biogenesis in human diploid fibroblast cells.Dec 31, 2017

Pubmed Data : Clin Exp Pharmacol Physiol. 2018 06 ;45(6):547-555. Epub 2018 Feb 13. PMID: 29319901
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Schisandra
Diseases : Aging, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor
[+]

Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3.Sep 04, 2018

Pubmed Data : Eur J Pharmacol. 2018 Sep 5 ;834:176-187. Epub 2018 Jul 20. PMID: 30036533
Article Published Date : Sep 04, 2018
Study Type : In Vitro Study
Additional Links
Substances : Honokiol, Lignans
Diseases : Liver Damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
[+]

Honokiol: An anticancer lignan.Oct 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Nov ;107:555-562. Epub 2018 Aug 13. PMID: 30114639
Article Published Date : Oct 31, 2018
Study Type : Review
Additional Links
Substances : Honokiol, Lignans
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Chemotherapeutic, NF-kappaB Inhibitor
[+]

Identification of methanol-soluble compounds in sesame and evaluation of antioxidant potential of its lignans.Apr 13, 2011

Pubmed Data : J Agric Food Chem. 2011 Apr 13 ;59(7):3214-9. Epub 2011 Mar 10. PMID: 21391595
Article Published Date : Apr 13, 2011
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Sesame Seeds, Sesamol
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

JWH-015, THC, CBD, Abn-CBD and O-1602 all protected SH-SY5Y cells from BV-2 conditioned media activated via LPS.Dec 31, 2013

Pubmed Data : Cell Mol Neurobiol. 2014 Jan ;34(1):31-42. Epub 2013 Sep 13. PMID: 24030360
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol, Cannabinoids , Delta-tetrahydrocannabinol (THC), Lignans
Diseases : Brain: Microglial Activation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Neuroprotective Agents
[+]

Lignans and flavonoids act as aromatase inhibitors in human preadipocytes. Aug 01, 1994

Pubmed Data : J Steroid Biochem Mol Biol. 1994 Aug;50(3-4):205-12. PMID: 8049151
Article Published Date : Aug 01, 1994
Study Type : In Vitro Study
Additional Links
Substances : Enterodiol, Flavonoids, Lignans
Diseases : Breast Cancer, Estrogen Dominance
Pharmacological Actions : Aromatase Inhibitors
[+]

Lignans are involved in the antitumor activity of wheat bran in colon cancer cells.Mar 01, 2005

Pubmed Data : J Nutr. 2005 Mar;135(3):598-602. PMID: 15735100
Article Published Date : Mar 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Fiber, Lignans, Wheat Bran
Diseases : Colon Cancer
Pharmacological Actions : Anticarcinogenic Agents, Cell cycle arrest, Chemopreventive
[+]

Lignans extracted from Vitex negundo possess cytotoxic activity by G2/M phase cell cycle arrest and apoptosis induction.May 14, 2013

Pubmed Data : Phytomedicine. 2013 May 15 ;20(7):640-7. Epub 2013 Apr 3. PMID: 23562365
Article Published Date : May 14, 2013
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Vitex negundo
Diseases : Breast Cancer: Triple Negative , Liver Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest
[+]

Lignans from Opuntia ficus-indica seeds protect rat primary hepatocytes and HepG2 cells against ethanol-induced oxidative stress.Dec 31, 2016

Pubmed Data : Biosci Biotechnol Biochem. 2017 Jan ;81(1):181-183. Epub 2016 Sep 22. PMID: 27885940
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Prickly Pear Cactus
Diseases : Alcohol Toxicity , Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective
[+]

Lignans from sandalwood (Santalum album) exhibit cytotoxicity to various cancer cells.Jan 01, 2010

Pubmed Data : Chem Pharm Bull (Tokyo). 2010;58(4):587-90. PMID: 20410650
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Sandalwood
Diseases : Leukemia, Lung Cancer, Promyelocytic leukemia
Pharmacological Actions : Apoptotic
[+]

Lignans from the seeds of Chinese hawthorn against β-amyloid aggregation.Jun 30, 2018

Pubmed Data : Nat Prod Res. 2018 Jul ;32(14):1706-1713. Epub 2017 Nov 8. PMID: 29115158
Article Published Date : Jun 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Lignans
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Lignin-derived oak phenolics, although found in small concentrations, may contribute to the beneficial antioxidant, chemopreventive, and cardioprotective effects of red wine.Nov 16, 2010

Pubmed Data : J Mol Model. 2010 Nov 16. Epub 2010 Nov 16. PMID: 21080014
Article Published Date : Nov 16, 2010
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Oak, Polyphenols, Red Wine Extract, Wine
Diseases : Cancers: All, Cardiovascular Diseases
Pharmacological Actions : Chemopreventive
[+]

Mammalian lignans and the soy isoflavone genistein inhibit breast cancer via down-regulation of estrogen production. Apr 01, 2005

Pubmed Data : J Steroid Biochem Mol Biol. 2005 Apr;94(5):461-7. Epub 2005 Mar 16. PMID: 15876411
Article Published Date : Apr 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Enterodiol, Enterolactone, Genistein, Lignans
Diseases : Breast Cancer, Estrogen Dominance
Pharmacological Actions : Aromatase Inhibitors
[+]

Mammalian lignans formed as a byproduct of flaxseed consumption inhibit prostate cancer cell growth. Nov 01, 2001

Pubmed Data : Anticancer Res. 2001 Nov-Dec;21(6A):3995-9. PMID: 11911282
Article Published Date : Nov 01, 2001
Study Type : In Vitro Study
Additional Links
Substances : Enterodiol, Enterolactone, Flaxseed, Lignans
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents
[+]

Mammalian lignans inhibit the growth of estrogen-independent human colon tumor cells.May 01, 1998

Pubmed Data : Anticancer Res. 1998 May-Jun;18(3A):1405-8. PMID: 9673348
Article Published Date : May 01, 1998
Study Type : In Vitro Study
Additional Links
Substances : Enterodiol, Enterolactone, Flaxseed, Lignans
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative
[+]

Natural lignans from Arctium lappa modulate P-glycoprotein efflux function in multidrug resistant cancer cells.Feb 14, 2015

Pubmed Data : Phytomedicine. 2015 Feb 15 ;22(2):301-7. Epub 2015 Jan 2. PMID: 25765837
Article Published Date : Feb 14, 2015
Study Type : In Vitro Study
Additional Links
Substances : Burdock, Lignans
Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Colon Cancer
Pharmacological Actions : Chemosensitizer, Multidrug Resistance Gene Modulators
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Schisandra contains compounds which protect against hypoxia/reoxygenation-induced cell death in cardiomyocytes. May 23, 2008

Pubmed Data : Life Sci. 2008 May 23;82(21-22):1092-101. Epub 2008 Mar 30. PMID: 18452952
Article Published Date : May 23, 2008
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Schisandra
Diseases : Hypoxia, Myocardial Ischemia
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

Schisandrol B protects against cholestatic liver injury through pregnane X receptors.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Pharmacol. 2017 04 ;174(8):672-688. Epub 2017 Mar 16. PMID: 28128437
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Schisandra
Diseases : Cholestasis, Liver Damage
Pharmacological Actions : Hepatoprotective
[+]

Sesame seed oil does not contain significant quantities of sesamol. Sep 01, 1987

Pubmed Data : Contact Dermatitis. 1987 Sep ;17(3):133-5. PMID: 3677654
Article Published Date : Sep 01, 1987
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Sesamol
[+]

Sesamin catechol glucuronides exert anti-inflammatory effects.Jul 09, 2019

Pubmed Data : J Agric Food Chem. 2019 Jul 10 ;67(27):7640-7649. Epub 2019 Apr 16. PMID: 30951310
Article Published Date : Jul 09, 2019
Study Type : In Vitro Study
Additional Links
Substances : Catechols, Lignans, Sesame Seeds
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Sesamin may be a potential chemotherapy drug for liver cancer treatment. Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2013 ;36(10):1540-8. PMID: 24088253
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Sesame Seeds, Sesamin
Diseases : Liver Cancer, Liver Cancer: Prevention
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Interleukin-6 Downregulation, STAT3 Inhibitor, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Seven new neuroprotective sesquineolignans isolated from the seeds of Crataegus pinnatifida.Feb 28, 2019

Pubmed Data : Fitoterapia. 2019 Mar ;133:225-230. Epub 2019 Jan 17. PMID: 30660653
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lignans
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

The mammalian phytoestrogens enterodiol and enterolactone may protect against breast and prostate cancer through hormone modulating activities.Sep 25, 2002

Pubmed Data : J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Sep 25;777(1-2):289-309. PMID: 12270221
Article Published Date : Sep 25, 2002
Study Type : Review
Additional Links
Substances : Enterodiol, Enterolactone, Flaxseed, Lignans, phytoestrogens, Secoisolariciresinol diglucoside (SDG)
Diseases : Breast Cancer, Cancers: All, Prostate Cancer
Pharmacological Actions : Aromatase Inhibitors
[+]

The relationship of antioxidant components and antioxidant activity of sesame seed oil.Sep 30, 2015

Pubmed Data : J Sci Food Agric. 2015 Oct ;95(13):2571-8. Epub 2015 Jan 23. PMID: 25472416
Article Published Date : Sep 30, 2015
Study Type : Review
Additional Links
Substances : Lignans, Sesame Seed Oil
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

These results suggest that sesamolin induces apoptosis in HCT116 cells.Jul 30, 2019

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2019 Jul 31 ;65(6):96-100. Epub 2019 Jul 31. PMID: 31472054
Article Published Date : Jul 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Sesame Seeds
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Interleukin-6 Downregulation, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, STAT3 Inhibitor
[+]

Tyrosinase inhibitory lignans from the methanol extract of the roots of Vitex negundo Linn. and their structure-activity relationship.Feb 28, 2006

Pubmed Data : Phytomedicine. 2006 Mar ;13(4):255-60. Epub 2005 Jun 27. PMID: 16492528
Article Published Date : Feb 28, 2006
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Vitex negundo
Pharmacological Actions : Tyrosinase Inhibition
Additional Keywords : Plant Extracts

Copyright: radiantskies / 123RF Stock Photo

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