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13 Diseases Researched for Long Pepper

Name	AC	CK
Parkinson's Disease	2	4
Lung Cancer	2	3
Aluminum Toxicity	1	2
Breast Cancer	1	2
Breast Cancer: Triple Negative	1	2
Cancers: All	1	2
Cerebral Ischemia	1	2
Chemically-Induced Liver Damage	1	2
Pancreatic Cancer	1	2
Stroke: Ischemic	1	2
Alzheimer's Disease	1	1
Leukemia	1	1
Leukemia: Acute promyelocytic leukemia	1	1

26 Pharmacological Actions Researched for Long Pepper

Name	AC	CK
Gastrointestinal Agents	1	10
Neuroprotective Agents	5	9
Apoptotic	4	6
Antioxidants	2	4
Cyclin D1 Down-Regulation	2	4
Anti-Apoptotic	1	2
Anti-Tumor	1	2
Anti-metastatic	1	2
Antiproliferative	1	2
Autophagy Inhibitors	1	2
Bcl-2 protein down-regulation	1	2
Chemosensitizer	1	2
Chemotherapeutic	2	2
Cytotoxic	1	2
Hepatoprotective	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	2
NF-kappaB Inhibitor	1	2
STAT3 Inhibitor	1	2
Superoxide Dismutase Up-regulation	1	2
Survivin Down-Regulation	1	2
Tumor Suppressor Protein p53 Upregulation	1	2
Vascular Endothelial Growth Factor Inhibitors	1	2
Autophagy Up-regulation	1	1
Caspase-3 Activation	1	1
Cyclooxygenase 2 Inhibitors	1	1
β-secretase Inhibitor	1	1

Research Articles 12
Cumulative Knowledge Score 19
Overall Research Rating GOOD

View the Evidence:
14 Abstracts with Long Pepper Research

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Prebiotic potential of culinary spices used to support digestion and bioabsorption.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:8973704. Epub 2019 Jun 2. PMID: 31281405

Article Published Date : Dec 31, 2018

Study Type : Human Study

Additional Links

Substances : Black Pepper, Culinary Herbs and Spices, Ginger, Long Pepper, Turmeric

Pharmacological Actions : Gastrointestinal Agents

Additional Keywords : Microbiota

[+]

Amelioration of cyclophosphamide-induced DNA damage, oxidative stress, and hepato- and neurotoxicity by Piper longum extract.Dec 31, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2023 ;14:1147823. Epub 2023 Mar 10. PMID: 36969834

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Long Pepper

Diseases : Chemically-Induced Liver Damage, Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Antioxidants, Chemoprotective Agents, Hepatoprotective

[+]

Co-treatment with piperlongumine led to a 1.68-fold enhancement in docetaxel bioavailability in SD rats.Sep 14, 2015

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Pubmed Data : J Pharm Sci. 2015 Sep 15. Epub 2015 Sep 15. PMID: 26372815

Article Published Date : Sep 14, 2015

Study Type : Animal Study

Additional Links

Substances : Long Pepper, Piperlongumine

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Cyclin D1 Down-Regulation, Cytotoxic, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Chemotherapeutic Synergy: Docetaxel

[+]

Dichloromethane extraction from Piper nigrum L. and P. longum L. to mitigate ischemic stroke.Aug 07, 2020

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Pubmed Data : Brain Res. 2020 Aug 8:147047. Epub 2020 Aug 8. PMID: 32781091

Article Published Date : Aug 07, 2020

Study Type : Animal Study

Additional Links

Substances : Black Pepper, Long Pepper

Diseases : Stroke: Ischemic

Pharmacological Actions : Anti-Apoptotic, Autophagy Inhibitors, Neuroprotective Agents

[+]

Neuroprotective Effect of Dichloromethane Extraction From Piper nigrum L. and Piper longum L.Feb 28, 2019

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Pubmed Data : J Stroke Cerebrovasc Dis. 2019 Mar ;28(3):751-760. Epub 2018 Dec 8. PMID: 30528673

Article Published Date : Feb 28, 2019

Study Type : Animal Study

Additional Links

Substances : Black Pepper, Long Pepper

Diseases : Cerebral Ischemia

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Piper longum possesses neuroprotective effects and has ameliorative properties in dopaminergic neurons.Sep 30, 2015

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Pubmed Data : Pharm Biol. 2015 Oct ;53(10):1516-24. Epub 2015 Apr 10. PMID: 25857256

Article Published Date : Sep 30, 2015

Study Type : Animal Study

Additional Links

Substances : Long Pepper

Diseases : Parkinson's Disease

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Superoxide Dismutase Up-regulation

[+]

Piperlongumine suppresses growth and sensitizes pancreatic tumors to gemcitabine in a xenograft mouse model.Dec 13, 2015

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Pubmed Data : Cancer Prev Res (Phila). 2015 Dec 14. Epub 2015 Dec 14. PMID: 26667450

Article Published Date : Dec 13, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Long Pepper

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative , Bcl-2 protein down-regulation, Chemosensitizer, Cyclin D1 Down-Regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor, Survivin Down-Regulation, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Chemotherapeutic Synergy: Gemcitabine

[+]

Piperlongumine was a direct STAT3 inhibitor and caused regression of breast cancer cell line xenografts in nude mice.Mar 30, 2014

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Pubmed Data : Oncogene. 2014 Mar 31 ;0. Epub 2014 Mar 31. PMID: 24681959

Article Published Date : Mar 30, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Long Pepper, Piperlongumine

Diseases : Breast Cancer, Cancers: All

Pharmacological Actions : Anti-metastatic, Anti-Tumor, Apoptotic, STAT3 Inhibitor

Additional Keywords : Disease Regression, Epigenetic Modification In Cancer

[+]

These findings provide novel insight into the neuroprotective function of Piper longum as well as evidence in favor of its use in PD treatment.Jul 28, 2015

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Pubmed Data : Brain Res. 2015 Jul 29. Epub 2015 Jul 29. PMID: 26232071

Article Published Date : Jul 28, 2015

Study Type : Animal Study

Additional Links

Substances : Long Pepper

Diseases : Parkinson's Disease

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

This animal study established the cytotoxic and hepatoprotective activity of P. longum extracts.Sep 30, 2014

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Pubmed Data : Indian J Biochem Biophys. 2014 Oct ;51(5):358-64. PMID: 25630105

Article Published Date : Sep 30, 2014

Study Type : Animal Study

Additional Links

Substances : Long Pepper

Diseases : Aluminum Toxicity , Chemically-Induced Liver Damage, Lung Cancer

Pharmacological Actions : Apoptotic, Hepatoprotective

Additional Keywords : Plant Extracts

[+]

Water extract of Piper longum ameliorates ovariectomy-induced bone loss Sep 04, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Sep 5 ;14(17). Epub 2022 Sep 5. PMID: 36079923

Article Published Date : Sep 04, 2022

Study Type : Animal Study

Additional Links

Substances : Long Pepper

Diseases : Osteoporosis

Pharmacological Actions : Osteoprotective

Additional Keywords : Ovariectomy-Induced Changes

[+]

Long-term consumption of aromatic compounds from spices could be effective in the prevention of Alzheimer's disease.Mar 31, 2016

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Pubmed Data : Nat Prod Commun. 2016 Apr ;11(4):507-10. PMID: 27396206

Article Published Date : Mar 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Cardamom, Cinnamon, Ginger, Long Pepper, Turmeric

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents, β-secretase Inhibitor

[+]

Piperlongumine and alpha lipoic acid may have a potential value as a therapeutic agent for patients with acute promyelocytic leukemia.Mar 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Cancer Res Ther. 2016 Apr-Jun;12(2):556-60. PMID: 27461609

Article Published Date : Mar 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Alpha-Lipoic Acid, Long Pepper, Piperlongumine

Diseases : Leukemia, Leukemia: Acute promyelocytic leukemia

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Chemotherapeutic, Cyclooxygenase 2 Inhibitors

Additional Keywords : Natural Substance Synergy

[+]

Piperlongumine induced apoptosis and autophagy through modulation of the PI3K/Akt/mTOR pathway in human lung cancer cells.Aug 31, 2015

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Pubmed Data : Int J Immunopathol Pharmacol. 2015 Sep ;28(3):362-73. Epub 2015 Aug 5. PMID: 26246196

Article Published Date : Aug 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Long Pepper, Piperlongumine

Diseases : Lung Cancer

Pharmacological Actions : Apoptotic, Autophagy Up-regulation, Chemotherapeutic

Long Pepper Related Articles

Herbs from India's Tribal Pouch: Ashwagandha

Written by Dr Deepak Acharya

Ashwagandha plays a vital role in different formulations prepared by the indigenous tribesmen of remote areas in India. The local herbal healers use different part of this plant for curing range of human health disorder. This article focuses on few traditional tribal formulations and remedial uses of Ashwagandha.

5 Therapeutic Herbs for Sciatica

Written by Dr Deepak Acharya

The fast paced urban life has resulted series of disorders and sciatica is one such disorder among many other. People with job of prolonged sitting and sedentary lifestyle are more prone to develop sciatica than those who are active and living with a set biological clock. Herbal healers (Bhumka) in Patalkot valley of India employ certain herbs for coping with sciatica. This article brings information about 5 wonder therapeutic herbs considered for taking care of sciatica.

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This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

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Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 14 Abstracts with Long Pepper Research

Limited to Members Only

Currently Available Sorting Options

Prebiotic potential of culinary spices used to support digestion and bioabsorption.Dec 31, 2018

Amelioration of cyclophosphamide-induced DNA damage, oxidative stress, and hepato- and neurotoxicity by Piper longum extract.Dec 31, 2022

Co-treatment with piperlongumine led to a 1.68-fold enhancement in docetaxel bioavailability in SD rats.Sep 14, 2015

Dichloromethane extraction from Piper nigrum L. and P. longum L. to mitigate ischemic stroke.Aug 07, 2020

Neuroprotective Effect of Dichloromethane Extraction From Piper nigrum L. and Piper longum L.Feb 28, 2019

Piper longum possesses neuroprotective effects and has ameliorative properties in dopaminergic neurons.Sep 30, 2015

Piperlongumine suppresses growth and sensitizes pancreatic tumors to gemcitabine in a xenograft mouse model.Dec 13, 2015

Piperlongumine was a direct STAT3 inhibitor and caused regression of breast cancer cell line xenografts in nude mice.Mar 30, 2014

These findings provide novel insight into the neuroprotective function of Piper longum as well as evidence in favor of its use in PD treatment.Jul 28, 2015

This animal study established the cytotoxic and hepatoprotective activity of P. longum extracts.Sep 30, 2014

Water extract of Piper longum ameliorates ovariectomy-induced bone loss Sep 04, 2022

Long-term consumption of aromatic compounds from spices could be effective in the prevention of Alzheimer's disease.Mar 31, 2016

Piperlongumine and alpha lipoic acid may have a potential value as a therapeutic agent for patients with acute promyelocytic leukemia.Mar 31, 2016

Piperlongumine induced apoptosis and autophagy through modulation of the PI3K/Akt/mTOR pathway in human lung cancer cells.Aug 31, 2015

Long Pepper Related Articles

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View the Evidence:
14 Abstracts with Long Pepper Research