Lotus

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114 Diseases Researched for Lotus
NameACCKFocus
Oxidative Stress1827Locked
Obesity1120Locked
Inflammation811Locked
High Fat Diet510Locked
Liver Cancer710Locked
Lung Cancer810Locked
Memory Disorders510Locked
Alzheimer's Disease69Locked
Diabetes Mellitus: Type 258Locked
Lipopolysaccharide-Induced Toxicity78Locked
Hypoxia37Locked
Lipid Peroxidation47Locked
Aging: Brain 36Locked
Endothelial Dysfunction46Locked
Ultraviolet Radiation Induced Damage56Locked
Aging35Locked
Cognitive Decline/Dysfunction35Locked
Gastric Cancer45Locked
Atherosclerosis44Locked
Cancers: Drug Resistant34Locked
Chemically-Induced Liver Damage34Locked
Depression24Locked
Diabetes: Cataract24Locked
Liver Fibrosis24Locked
Sleep Disorders24Locked
Ulcerative Colitis24Locked
Breast Cancer33Locked
Breast Cancer: Triple Negative 33Locked
Carcinoma: Non-Small-Cell Lung23Locked
Chemotherapy-Induced Toxicity: Doxorubicin33Locked
Colon Cancer33Locked
Diabetes Mellitus: Type 123Locked
Hypertension23Locked
Kidney Damage23Locked
Nonalcoholic fatty liver disease (NAFLD)23Locked
Osteoarthritis33Locked
Ovarian Cancer23Locked
Prostate Cancer33Locked
Stroke: Ischemic23Locked
Aluminum Toxicity 12Locked
Anxiety12Locked
Anxiety Disorders12Locked
Arteriosclerosis12Locked
Asthma12Locked
Brain Damage12Locked
Cancers: All22Locked
Cancers: Multi-Drug Resistant22Locked
Cardiovascular Diseases22Locked
Cervical Cancer22Locked
Chemotherapy-Induced Toxicity: Cisplatin22Locked
Diabetes: Cognitive Dysfunction12Locked
Diabetes: Glycation/A1C12Locked
Diabetic Complications12Locked
Diabetic Nephropathy12Locked
Diabetic Ulcer12Locked
Epilepsy12Locked
Fever12Locked
HIV Infections22Locked
Hepatic Steatosis12Locked
Hyperuricemia12Locked
Insulin Resistance12Locked
Learning disorders12Locked
Liver Cirrhosis12Locked
Lupus Erythematosus: Systemic12Locked
Myocardial Fibrosis 12Locked
Nasopharyngeal Cancer22Locked
Neurodegeneration: Dentate Gyrus12Locked
Neuropathic Pain12Locked
Nicotine/Tobacco Toxicity 12Locked
Prostatic Hyperplasia: Benign22Locked
Seizures12Locked
Squamous cell carcinoma12Locked
Triglycerides: Elevated12Locked
Wound Healing12Locked
Acute Respiratory Distress Syndrome11Locked
Aging Skin11Locked
Cardiac Hypertrophy11Locked
Chemotherapy and Radiation Toxicity11Locked
Choriocarcinoma11Locked
Chronic Kidney Disease (CKD)11Locked
Chronic Myeloid Leukemia11Locked
Colorectal Cancer11Locked
Coxsackievirus Infections11Locked
DNA damage11Locked
Diabetes Mellitus: Type 2: Prevention11Locked
Dyslipidemias11Locked
Electromagnetic Radiation Mitigation11Locked
Esophageal Cancer11Locked
Gastrointestinal Cancer11Locked
Glioblastoma11Locked
Glioma11Locked
Graves Disease11Locked
HSV-111Locked
Huntington Disease11Locked
Hydrogen Peroxide Induced Toxicity11Locked
Hyperglycemia11Locked
Immune Disorders: Low Immune Function11Locked
Influenza11Locked
Kidney Cancer11Locked
Liver Damage11Locked
Melanoma11Locked
Memory Disorders: Drug-Induced11Locked
Muscle Damage11Locked
Neuroblastoma11Locked
Neurodegenerative Diseases11Locked
Oral Cancer11Locked
Osteoporosis11Locked
Photooxidative Stress11Locked
Respiratory Infections11Locked
Restenosis11Locked
Retinal Detachment11Locked
Retinoblastoma11Locked
Rhinovirus Infection 11Locked
Rotavirus Infections11Locked
89 Pharmacological Actions Researched for Lotus
NameACCKFocus
Antioxidants4465Locked
Anti-Inflammatory Agents2641Locked
Apoptotic2325Locked
Neuroprotective Agents1625Locked
Antiproliferative 2124Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor1324Locked
Hepatoprotective1118Locked
Interleukin-6 Downregulation917Locked
NF-kappaB Inhibitor1115Locked
Interleukin-1 beta downregulation813Locked
Anti-Apoptotic1011Locked
Nrf2 activation710Locked
Autophagy Up-regulation99Locked
Cardioprotective89Locked
Chemosensitizer89Locked
Chemoprotective Agents78Locked
Cyclooxygenase 2 Inhibitors68Locked
Cytoprotective48Locked
Hypoglycemic Agents58Locked
Superoxide Dismutase Up-regulation58Locked
Hypolipidemic57Locked
Malondialdehyde Down-regulation47Locked
Renoprotective47Locked
Anti-metastatic66Locked
Interleukin-8 downregulation26Locked
Photoprotective56Locked
Chemotherapeutic45Locked
Immunomodulatory35Locked
Aldose reductase inhibitor 24Locked
Angiogenesis Inhibitors34Locked
Anticarcinogenic Agents34Locked
Antidepressive Agents24Locked
Bcl-2 protein down-regulation44Locked
Chemopreventive34Locked
Heme oxygenase-1 up-regulation44Locked
MicroRNA modulator44Locked
Osteoprotective 44Locked
Antihypertensive Agents23Locked
Antiviral Agents33Locked
Cell cycle arrest33Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor33Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor33Locked
Neuritogenic23Locked
Vasodilator Agents23Locked
Analgesics12Locked
Anti-Angiogenic22Locked
Anti-Anxiety Agents12Locked
Anti-Fibrotic12Locked
Anti-Ulcer Agents12Locked
Anti-pyretic 12Locked
Anticholesteremic Agents12Locked
Anticonvulsants12Locked
Anxiolytic12Locked
Bax/Bcl2 Ratio: Decrease12Locked
Cytotoxic12Locked
GABA Modulators12Locked
Gastrointestinal Agents12Locked
Histamine Antagonists12Locked
Hypnotics and Sedatives12Locked
Interleukin-10 upregulation12Locked
Neurogenesis12Locked
Nitric Oxide Inhibitor12Locked
Sedative effects12Locked
Vascular Cell Adhesion Molecule-1 Inhibitor 12Locked
Vascular Endothelial Growth Factor Inhibitors22Locked
Wnt/β-catenin pathway down-regulation12Locked
Acetylcholinesterase Inhibitor11Locked
Alpha-amylase inhibitor11Locked
Anti-Adipogenic11Locked
Anti-HIV Agents11Locked
Anti-Retroviral Agents11Locked
Antimicrobial11Locked
Antineoplastic Agents11Locked
Autophagy Inhibitors11Locked
Bcl-xL down-regulation11Locked
Brain-derived neurotrophic factor modulator11Locked
Caspase-3 Activation11Locked
Caspase-8 activation11Locked
Caspase-9 Activation11Locked
Catalase Up-Regulation11Locked
Cholinesterase Inhibitors11Locked
Enzyme Inhibitors: Pancreatic Amylase11Locked
Immunostimulatory11Locked
Insulin-releasing11Locked
Matrix metalloproteinase-1 (MMP-1) inhibitor11Locked
NF-E2-Related Factor-2 (Nrf2) Modulator11Locked
P21 Activation11Locked
Postaglandin PGE2 downregulation 11Locked
Prophylactic Agents11Locked

View the Evidence:
180 Abstracts with Lotus Research

[+]

Neferine exerts a cytoprotective effect against hypoxia-induced oxidative stress and inflammation in human peripheral blood mononuclear cells.Jul 08, 2017

Pubmed Data : Biomed Pharmacother. 2017 Jul 9 ;93:730-736. Epub 2017 Jul 9. PMID: 28700977
Article Published Date : Jul 08, 2017
Study Type : Human In Vitro
Additional Links
Substances : Lotus
Diseases : Hypoxia, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cytoprotective, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

A compound found within Lotus flower may positively modulate immune function in autoimmune disease like systemic lupus erythematosus. Feb 15, 2006

Pubmed Data : Eur J Pharmacol. 2006 Feb 15;531(1-3):270-9. Epub 2006 Jan 17. PMID: 16413531
Article Published Date : Feb 15, 2006
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Lupus Erythematosus: Systemic
[+]

A dietary supplement of nuciferine rich in lotus leaf may have potential for the prevention and treatment of hyperuricemia with kidney inflammation.Jan 14, 2015

Pubmed Data : Eur J Pharmacol. 2015 Jan 15 ;747:59-70. Epub 2014 Dec 8. PMID: 25499818
Article Published Date : Jan 14, 2015
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Hyperuricemia, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Renoprotective
[+]

A multiple-targets alkaloid nuciferine overcomes paclitaxel-induced drug resistance in vitro and in vivo.Sep 09, 2020

Pubmed Data : Phytomedicine. 2020 Sep 10 ;79:153342. Epub 2020 Sep 10. PMID: 32992085
Article Published Date : Sep 09, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cancers: Drug Resistant, Lung Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Alkaloids extracted from lotus leaves might be a new complementary treatment to treat abnormal contractions of the trachea and asthma.Mar 19, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2017 Mar 20 ;17(1):159. Epub 2017 Mar 20. PMID: 28320373
Article Published Date : Mar 19, 2017
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Asthma
Additional Keywords : Asthma, Lotus, Plant Extracts
[+]

An combined extract of lotus, white mulberry and radish may be a natural anti-obesity agent.May 18, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2019 May 19 ;8(5). Epub 2019 May 19. PMID: 31109115
Article Published Date : May 18, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus , Radish, White Mulberry
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents, Plant Extracts
[+]

Anti-obesity and antidiabetic effects of nelumbinis semen powder in high-fat diet-induced obese.Nov 21, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Nov 22 ;12(11). Epub 2020 Nov 22. PMID: 33266423
Article Published Date : Nov 21, 2020
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : High Fat Diet, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Anti-obesity effects of a Prunus persica and Nelumbo nucifera mixture in mice fed a high-fat diet.Nov 03, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Nov 4 ;12(11). Epub 2020 Nov 4. PMID: 33158191
Article Published Date : Nov 03, 2020
Study Type : Animal Study
Additional Links
Substances : Lotus , Peach
Diseases : High Fat Diet, Obesity
Additional Keywords : Anti-Obesity Agents
[+]

Chemomodulatory effect of neferine on DMBA-induced squamous cell carcinogenesis.Nov 05, 2020

Pubmed Data : Environ Toxicol. 2020 Nov 6. Epub 2020 Nov 6. PMID: 33156559
Article Published Date : Nov 05, 2020
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Squamous cell carcinoma
Pharmacological Actions : Chemopreventive
[+]

Evaluation of antiinflammatory activity of ethanol extract of Nelumbo nucifera fruit.Feb 24, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Turk J Pharm Sci. 2021 Feb 25 ;18(1):56-60. PMID: 33633265
Article Published Date : Feb 24, 2021
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Extracts from Nelumbo nucifera leaves had significantly hepatoprotective effect for Calcium tetrachloride CCl4-induced liver injury.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Afr J Tradit Complement Altern Med. 2014 ;11(3):85-91. Epub 2014 Apr 3. PMID: 25371567
Article Published Date : Dec 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Phytotherapy, Plant Extracts
[+]

GABA contained in lotus seed extract acts as a sleep potentiating compound.Feb 28, 2021

Pubmed Data : J Ethnopharmacol. 2021 Mar 1 ;267:113511. Epub 2020 Oct 23. PMID: 33148434
Article Published Date : Feb 28, 2021
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Sleep Disorders
Pharmacological Actions : GABA Modulators
[+]

Isoliensinine from Nelumbo nucifera induces hepatocellular carcinoma cell apoptosis.Oct 13, 2015

Pubmed Data : J Agric Food Chem. 2015 Oct 14 ;63(40):8793-803. Epub 2015 Oct 1. PMID: 26389520
Article Published Date : Oct 13, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor
[+]

Long-term intake of the lotus seed tea showed the effect of preventing loss of skin moisture, mitigating the formation of abnormal keratinocytes.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Prev Nutr Food Sci. 2015 Sep ;20(3):162-8. Epub 2015 Sep 30. PMID: 26451352
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Ultraviolet Radiation Induced Damage
Pharmacological Actions : Antioxidants, Photoprotective
[+]

Lotus flower leaf has anti-obesity effects in mice.Jun 09, 2010

Pubmed Data : J Agric Food Chem. 2010 Jun 9;58(11):7075-81. PMID: 20481471
Article Published Date : Jun 09, 2010
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Lotus
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents, Plant Extracts
[+]

Lotus has antipyretic properties.Jun 01, 2000

Pubmed Data : Phytother Res. 2000 Jun;14(4):272-4. PMID: 10861971
Article Published Date : Jun 01, 2000
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Fever
Pharmacological Actions : Anti-pyretic
[+]

Lotus has immunomodulatory effects. Jan 05, 2010

Pubmed Data : Psychol Med. 2010 Jan 5:1-11. Epub 2010 Jan 5. PMID: 20095810
Article Published Date : Jan 05, 2010
Study Type : Animal Study
Additional Links
Substances : Lotus
Pharmacological Actions : Histamine Antagonists, Immunomodulatory, Nitric Oxide Inhibitor
[+]

Lotus leaf hot water extract with taurine supplementation showed antiobesity and hypolipidemic effects in high fat diet-induced obese rats.Jun 23, 2006

Pubmed Data : J Biol Chem. 2006 Jun 23;281(25):17359-68. Epub 2006 Apr 17. PMID: 20804619
Article Published Date : Jun 23, 2006
Study Type : Animal Study
Additional Links
Substances : Lotus , Taurine
Diseases : Obesity
Additional Keywords : Natural Substance Synergy
[+]

Lotus leaves have an anti-obesity effect in mice. Feb 01, 2008

Pubmed Data : Biosci Biotechnol Biochem. 2008 Feb;72(2):477-84. Epub 2008 Feb 7. PMID: 16495025
Article Published Date : Feb 01, 2008
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents, Plant Extracts
[+]

Lotus procyanidins reverse memory impairments in cognitivitely impaired aged rats.Sep 01, 2010

Pubmed Data : J Gerontol A Biol Sci Med Sci. 2010 Sep;65(9):933-40. Epub 2010 Jun 7. PMID: 20530246
Article Published Date : Sep 01, 2010
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Aging, Aging: Brain , Cognitive Decline/Dysfunction, Memory Disorders
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Lotus root extract with taurine has an antioxidant and hepatoprotective effect in rats fed a high fat diet.Jan 01, 2010

Pubmed Data : J Biomed Sci. 2010;17 Suppl 1:S39. Epub 2010 Aug 24. PMID: 20804615
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Lotus , Taurine
Diseases : Obesity
Pharmacological Actions : Antioxidants, Hepatoprotective
[+]

Lotus seed extract has a hypoglycemic effect in diabetic rats.Nov 01, 2004

Pubmed Data : Carcinogenesis. 2004 Nov;25(11):2183-9. Epub 2004 Jul 15. PMID: 20165930
Article Published Date : Nov 01, 2004
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Hypoglycemic Agents
[+]

Lotus seed extract improves memory in cognitively impaired aged rats.Dec 01, 2009

Pubmed Data : Eur Neuropsychopharmacol. 2009 Dec;19(12):851-60. Epub 2009 Aug 27. PMID: 19716273
Article Published Date : Dec 01, 2009
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Aging: Brain , Cognitive Decline/Dysfunction, Memory Disorders
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Lotus seed procyanidins prevent oxidative stress by extremely low frequency electromagnetic fields in mice.Aug 01, 2016

Pubmed Data : Biomed Pharmacother. 2016 Aug ;82:640-8. Epub 2016 Jun 13. PMID: 27470407
Article Published Date : Aug 01, 2016
Study Type : Animal Study
Additional Links
Substances : Lotus , Proanthocyanidins
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Malondialdehyde Down-regulation
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation
Adverse Pharmacological Actions : Oxidant
[+]

Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway.Dec 31, 2018

Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2019 Jan 1 ;51(1):31-40. PMID: 30544155
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus , Proanthocyanidins
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Nrf2 activation
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Lotus seedpod proanthyocyanins have an ameliorative effect on cognitive deficits and oxidative damage in senescence-accelerated mice.Dec 01, 2008

Pubmed Data : Behav Brain Res. 2008 Dec 1;194(1):100-7. Epub 2008 Jul 4. PMID: 18652848
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Additional Links
Substances : Anthocyanins, Lotus
Diseases : Aging, Aging: Brain , Oxidative Stress
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Proanthocyanidins
[+]

Lotus seedpod procyanidins mitigate the oxidative effects and learning and memory damage caused by extremely low frequency electromagnetic fields onAug 01, 2013

Pubmed Data : Food Funct. 2013 Aug ;4(8):1252-62. PMID: 23764910
Article Published Date : Aug 01, 2013
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Learning disorders, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts, Proanthocyanidins
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation
Adverse Pharmacological Actions : Neurotoxic, Oxidant
[+]

Lotus stamen has aldose reductase inhibitory which may have value in preventing diabetes-associated eye damage. Oct 01, 2006

Pubmed Data : Phytother Res. 2006 Oct;20(10):825-30. PMID: 16881021
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Lotus
Diseases : Diabetes: Cataract
Pharmacological Actions : Aldose reductase inhibitor
Additional Keywords : Plant Extracts
[+]

N. nucifera extract is the potential neuroprotective and memory enhancing agent. Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:5789857. Epub 2015 Dec 8. PMID: 26858824
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Brain Damage, Memory Disorders
Pharmacological Actions : Antioxidants, Neurogenesis, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

N. nucifera fruit exhibited strong anxiolytic and antidepressant effects.Jan 31, 2017

Pubmed Data : Metab Brain Dis. 2017 Feb 1. Epub 2017 Feb 1. PMID: 28144887
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Anxiety, Depression
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
[+]

N. nucifera fruit may be valuable in managing epilepsy.Aug 02, 2017

Pubmed Data : Metab Brain Dis. 2017 Aug 3. Epub 2017 Aug 3. PMID: 28776277
Article Published Date : Aug 02, 2017
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
Additional Keywords : Anticonvulsants, epilepsy, Lotus, Natural Substances Versus Drugs
[+]

Neferine alleviates memory and cognitive dysfunction in diabetes.Jun 30, 2020

Pubmed Data : Int Immunopharmacol. 2020 Jul ;84:106559. Epub 2020 May 8. PMID: 32402951
Article Published Date : Jun 30, 2020
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetes: Cognitive Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Neferine alleviates neuropathic pain by downregulating the expression of P2X3 receptor.Aug 31, 2020

Pubmed Data : Neurosci Res. 2020 Sep 1. Epub 2020 Sep 1. PMID: 32882253
Article Published Date : Aug 31, 2020
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Neuropathic Pain
Pharmacological Actions : Analgesics
[+]

Neferine ameliorates dextran sulfate sodium-induced ulcerative colitis.Dec 31, 2017

Pubmed Data : Am J Chin Med. 2018 ;46(6):1263-1279. Epub 2018 Aug 27. PMID: 30149754
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Phytotherapy
[+]

Neferine extracted from Lotus seed has sedative anti-anxiety effects.Dec 01, 2008

Pubmed Data : Phytomedicine. 2008 Dec;15(12):1117-24. PMID: 19010651
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Anxiety Disorders, Seizures
Pharmacological Actions : Anxiolytic, Hypnotics and Sedatives
Additional Keywords : Plant Extracts
[+]

Neferine had an antifibrosis effect on carbon tetrachloride-induced hepatic fibrosis in mice.Dec 31, 2014

Pubmed Data : Am J Chin Med. 2015 ;43(2):231-40. Epub 2015 Mar 24. PMID: 25800905
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Hepatoprotective
Additional Keywords : Dose Response, Phytotherapy
[+]

Neferine is an attractive reagent with great potential in high-grade serous ovarian carcinoma therapy.Sep 27, 2018

Pubmed Data : Cancer Lett. 2018 Sep 28 ;432:144-155. Epub 2018 Jun 5. PMID: 29879497
Article Published Date : Sep 27, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus
Diseases : Ovarian Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Chemotherapeutic
[+]

Neferine may have antifibrogenic effects in diabetes-related cardiac fibrosis.Sep 19, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Sep 20 ;7(38):61703-61715. PMID: 27533252
Article Published Date : Sep 19, 2016
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetic Complications, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
Additional Keywords : Anti-Fibrotic, Cardioprotective, Diabetic Complications, Lotus, Myocardial Fibrosis
[+]

Neferine may serve as an effective regulator during the pathogenesis of vascular inflammatory diseases.Jan 14, 2020

Pubmed Data : Arch Biochem Biophys. 2020 12 15 ;696:108595. Epub 2020 Nov 4. PMID: 33157101
Article Published Date : Jan 14, 2020
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Endothelial Dysfunction, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Interleukin-1 beta downregulation, Vascular Cell Adhesion Molecule-1 Inhibitor
[+]

Neferine might have therapeutic potential for ischaemic stroke Nov 09, 2018

Pubmed Data : Br J Pharmacol. 2018 Nov 10. Epub 2018 Nov 10. PMID: 30414381
Article Published Date : Nov 09, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus
Diseases : Stroke: Ischemic
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Neferine mitigated renal injury in acute kidney injury models.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:1197. Epub 2019 Oct 15. PMID: 31680971
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus
Diseases : Kidney Damage
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Renoprotective
[+]

Neferine protects against hypoxic-ischemic brain damage.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2021 ;2021:6654954. Epub 2021 May 8. PMID: 34046147
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Encephalopathy: Hypoxic, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Neferine significantly promotes a fast and efficient wound healing.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Artif Cells Nanomed Biotechnol. 2020 Dec ;48(1):96-106. PMID: 31852261
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetic Ulcer, Wound Healing
Pharmacological Actions : Anti-Inflammatory Agents, Anti-Ulcer Agents
[+]

Neferine, a compound extracted from Nulembo nucifera, has a similar effect to rosiglitazone (Avandia) in decreasing fasting blood glucose, insulin, TG, TNF-alpha and enhancing insulin sensitivity in insulin resistant rats.Jul 06, 2009

Pubmed Data : J Ethnopharmacol. 2009 Jul 6;124(1):98-102. Epub 2009 Apr 11. PMID: 19527823
Article Published Date : Jul 06, 2009
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetes Mellitus: Type 2, Insulin Resistance, Triglycerides: Elevated
Pharmacological Actions : Hypoglycemic Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substances Versus Drugs
[+]

Nelumbo nucifera contains a compound which exhibits vitro and in vivo antifibrotic effects in rats with liver fibrosis. Sep 02, 2009

Pubmed Data : J Biomed Sci. 2009 Sep 2;16:78. PMID: 19723340
Article Published Date : Sep 02, 2009
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Liver Fibrosis
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Nelumbo nucifera extract exhibits anti-atherogenic activity by inhibiting the proliferation and migration of vascular smooth muscle cells in an animal model of atherosclerosis. Sep 30, 2009

Pubmed Data : Food Chem Toxicol. 2009 Sep 30. PMID: 19799955
Article Published Date : Sep 30, 2009
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Arteriosclerosis
Pharmacological Actions : Antiproliferative
[+]

Nelumbo nucifera fruit seems to have great potential for therapeutic application in memory disorders.Sep 30, 2018

Pubmed Data : Metab Brain Dis. 2018 Oct 1. Epub 2018 Oct 1. PMID: 30270417
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Alzheimer's Disease, Memory Disorders
Pharmacological Actions : Neuroprotective Agents
[+]

Nelumbo nucifera improves memory and neurogenesis in the dentate gyrus of the rat hippocampusOct 03, 2008

Pubmed Data : Neurosci Lett. 2008 Oct 3;443(2):104-7. Epub 2008 Jul 11. PMID: 18638527
Article Published Date : Oct 03, 2008
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Neurodegeneration: Dentate Gyrus
Pharmacological Actions : Neuritogenic
Additional Keywords : Hippocampus Regeneration
[+]

Nelumbo nucifera leaf extract treatment attenuated preneoplastic lesions and oxidative stress in the livers of diethylnitrosamine-treated rats.Aug 13, 2017

Pubmed Data : Environ Toxicol. 2017 Aug 14. Epub 2017 Aug 14. PMID: 28804948
Article Published Date : Aug 13, 2017
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants
[+]

Nelumbo nucifera leaves extract attenuate the pathological progression of diabetic nephropathy.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Food Drug Anal. 2019 Jul ;27(3):736-748. Epub 2019 Jan 8. PMID: 31324289
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetic Nephropathy, High Fat Diet
Pharmacological Actions : Antioxidants, Nrf2 activation, Renoprotective
[+]

Nelumbo nucifera leaves have a therapeutic effect on rat lens aldose reductase, advanced glycation endproduct formation and oxidative stress. Dec 01, 2008

Pubmed Data : Food Chem Toxicol. 2008 Dec;46(12):3818-26. Epub 2008 Oct 10. PMID: 18952135
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetes: Cataract, Diabetes: Glycation/A1C
Pharmacological Actions : Aldose reductase inhibitor , Antioxidants
[+]

Nelumbo nucifera seed extract promotes sleep in drosophila melanogaster.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2018 ;41(3):399-408. PMID: 29491217
Article Published Date : Dec 31, 2017
Study Type : Insect Study
Additional Links
Substances : Lotus
Diseases : Sleep Disorders
Pharmacological Actions : Sedative effects
[+]

Nootropic effect of neferine on aluminium chloride-induced Alzheimer's disease in experimental models. Jan 31, 2020

Pubmed Data : J Biochem Mol Toxicol. 2020 Feb ;34(2):e22429. Epub 2019 Dec 20. PMID: 31860774
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Aluminum Toxicity , Alzheimer's Disease, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Aluminum Chloride
[+]

Nuciferine could treat obesity through modulating gut microbiota, decreasing gut permeability and ameliorating inflammation.Mar 31, 2021

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2021 Apr ;46(8):2104-2111. PMID: 33982526
Article Published Date : Mar 31, 2021
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Obesity Agents
[+]

Nuciferine from Nelumbo nucifera Gaertn. attenuates isoproterenol-induced myocardial infarction.May 15, 2021

Pubmed Data : Biotechnol Appl Biochem. 2021 May 16. Epub 2021 May 16. PMID: 33998037
Article Published Date : May 15, 2021
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Myocardial Infarction
Pharmacological Actions : Cardioprotective
Problem Substances : Isoproterenol
[+]

Nuciferine may be a potentially important candidate in improving hepatic steatosis and the management of T2DM.Oct 31, 2018

Pubmed Data : Br J Pharmacol. 2018 Nov ;175(22):4218-4228. Epub 2018 Oct 11. PMID: 30129056
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetes Mellitus: Type 2, Hepatic Steatosis
Pharmacological Actions : Anticholesteremic Agents, Antioxidants, Hepatoprotective
[+]

Nuciferine modulates the gut microbiota and prevents obesity in high-fat diet-fed rats.Jan 11, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Mol Med. 2020 12 ;52(12):1959-1975. Epub 2020 Dec 1. PMID: 33262480
Article Published Date : Jan 11, 2020
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : High Fat Diet, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents
Additional Keywords : Anti-Obesity Agents
[+]

Nuciferine not only inhibited the growth of NSCLC cells, but also remarkably alleviated the injury induced by nicotine in liver function.May 12, 2015

Pubmed Data : J Ethnopharmacol. 2015 May 13 ;165:83-93. Epub 2015 Feb 16. PMID: 25698245
Article Published Date : May 12, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer, Nicotine/Tobacco Toxicity
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 Ratio: Decrease, Hepatoprotective, Wnt/β-catenin pathway down-regulation
[+]

Procyanidins extracted from lotus seedpod ameliorate amyloid-β-induced toxicity in rat pheochromocytoma cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:4572893. Epub 2018 Oct 28. PMID: 30538801
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Procyanidins extracted from the lotus seedpod ameliorate scopolamine-induced memory impairment in mice.Jan 13, 2010

Pubmed Data : Phytother Res. 2010 Jan 13. Epub 2010 Jan 13. PMID: 19367674
Article Published Date : Jan 13, 2010
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Memory Disorders
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Protection against dextran sulfate sodium-induced ulcerative colitis in mice by neferine.Dec 31, 2020

Pubmed Data : Cell J. 2021 Jan ;22(4):523-531. Epub 2020 Apr 22. PMID: 32347046
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The mixture of Eriobotrya japonica and Nelumbo nucifera extract may strongly regulate body weight gain.Dec 31, 2014

Pubmed Data : Am J Chin Med. 2015 ;43(4):681-94. Epub 2015 Jul 1. PMID: 26133751
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Loquat, Lotus
Diseases : High Fat Diet, Obesity
Pharmacological Actions : Hypolipidemic
Additional Keywords : Anti-Obesity Agents, Dose Response, Natural Substance Synergy
[+]

This provides a new theoretical basis for Nelumbo nucifera Gaertn stem as an antidepressant-like agent.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:3056954. Epub 2020 Mar 30. PMID: 32308703
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
[+]

This study demonstrated an amelioration of the metabolic disorders following nuciferine treatment in NAFLD.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:858. Epub 2020 Jun 9. PMID: 32581811
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Treatments with lotus seedpod oligomeric procyanidins could be beneficial in diabetic treatments.May 16, 2017

Pubmed Data : J Agric Food Chem. 2017 May 17 ;65(19):3801-3810. Epub 2017 May 8. PMID: 28314100
Article Published Date : May 16, 2017
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic
Additional Keywords : Plant Extracts, Proanthocyanidins
Problem Substances : Insulin
[+]

Vasorelaxant and antihypertensive effects of neferine.Apr 30, 2020

Pubmed Data : Planta Med. 2020 May ;86(7):496-504. Epub 2020 Mar 27. PMID: 32219782
Article Published Date : Apr 30, 2020
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Endothelial Dysfunction, Hypertension
Pharmacological Actions : Antihypertensive Agents, Vasodilator Agents
[+]

Water-soluble polysaccharides from lotus seeds can be used as an antitumor and immunomodulatory agent.Nov 01, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2016 Nov 2 ;21(11). Epub 2016 Nov 2. PMID: 27827862
Article Published Date : Nov 01, 2016
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Gastric Cancer, Liver Cancer
Pharmacological Actions : Antioxidants, Antiproliferative , Cytotoxic, Immunomodulatory, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
Additional Keywords : Natural Substances Versus Drugs, Polysaccharides
[+]

A comprehensive review of the benefits of neferine.Feb 26, 2018

Pubmed Data : Life Sci. 2018 Feb 27. Epub 2018 Feb 27. PMID: 29499283
Article Published Date : Feb 26, 2018
Study Type : Review
Additional Links
Substances : Lotus
Diseases : Cancers: All, Chemotherapy-Induced Toxicity: Cisplatin, HIV Infections, Inflammation
Pharmacological Actions : Anti-Retroviral Agents, Antimicrobial, Antiproliferative , Apoptotic, Chemoprotective Agents, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Alkaloids from the Ba lotus seed have anticancer activity through inducing cellular apoptosis.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Nov ;12(5):3113-3120. Epub 2016 Sep 20. PMID: 27882126
Article Published Date : Oct 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

An alkaloid rich fraction from Nelumbo nucifera targets VSMC proliferation and migration to attenuate neo-intima formation.Mar 20, 2016

Pubmed Data : Atherosclerosis. 2016 Mar 21 ;248:179-189. Epub 2016 Mar 21. PMID: 27018542
Article Published Date : Mar 20, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Atherosclerosis, Restenosis
Pharmacological Actions : Antiproliferative , Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

An extract of Lotus may be a powerful agent against colon cancer cells.Feb 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2017 Mar ;13(3):1470-1478. Epub 2016 Dec 28. PMID: 28454279
Article Published Date : Feb 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
Additional Keywords : Apoptotic, Bcl-2 protein down-regulation, COLON CANCER, Lotus, Plant Extracts
[+]

Anti-aging potential and phytochemicals of Centella asiatica, Nelumbo nucifera, and Hibiscus sabdariffa extracts.Sep 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Adv Pharm Technol Res. 2020 Oct-Dec;11(4):174-178. Epub 2020 Oct 10. PMID: 33425700
Article Published Date : Sep 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Gotu Kola, Hibiscus sabdariffa , Lotus
Diseases : Aging
[+]

Anti-inflammatory effects of fermented lotus root and linoleic acid in lipopolysaccharide-induced RAW 264.7 cells.Nov 18, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Life (Basel). 2020 Nov 19 ;10(11). Epub 2020 Nov 19. PMID: 33228085
Article Published Date : Nov 18, 2020
Study Type : In Vitro Study
Additional Links
Substances : Fermented Foods and Beverages, Linoleic acid, Lotus
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Anticariogenic activity of Nelumbo nucifera leaf extract in oral healthcare.May 06, 2019

Pubmed Data : Technol Health Care. 2019 May 7. Epub 2019 May 7. PMID: 31127738
Article Published Date : May 06, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Oral Cancer
Pharmacological Actions : Anticarcinogenic Agents
[+]

Antioxidant, cholinesterase inhibition activities and essential oil analysis of Nelumbo nucifera seeds.May 31, 2016

Pubmed Data : Nat Prod Res. 2016 Jun ;30(11):1335-8. Epub 2015 Jul 27. PMID: 26212099
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Lotus
Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants
Additional Keywords : Essential Oils
[+]

Benzylisoquinoline alkaloids from Nelumbo nucifera Gaertn. petals with antiausterity activities against the HeLa human cervical cancer cell line.May 20, 2021

Pubmed Data : Z Naturforsch C J Biosci. 2021 May 21. Epub 2021 May 21. PMID: 34019754
Article Published Date : May 20, 2021
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic
[+]

Blood-brain barrier-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells.Nov 08, 2019

Pubmed Data : J Nat Med. 2019 Nov 9. Epub 2019 Nov 9. PMID: 31707550
Article Published Date : Nov 08, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuritogenic
Additional Keywords : Blood Brain Barrier
[+]

Botanical formulation HX109 ameliorates TP-induced benign prostate hyperplasia. Dec 06, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Dec 7 ;10(12). Epub 2018 Dec 7. PMID: 30544543
Article Published Date : Dec 06, 2018
Study Type : In Vitro Study
Additional Links
Substances : Dandelion , Lotus
Diseases : Prostatic Hyperplasia: Benign
Additional Keywords : Plant Extracts
[+]

Discovery of bioactive natural products for the treatment of acute respiratory infections.Jun 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Planta Med. 2018 Jul ;84(9-10):684-695. Epub 2018 Mar 19. PMID: 29554706
Article Published Date : Jun 30, 2018
Study Type : Review
Additional Links
Substances : Anise, Bael , Black Currant, Black Pepper, Blackberry, Carrot, Chrysanthemum Indicum, Cinnamon, Elderberry, Fennel, Frankincense, Garlic, Honeysuckle, Lemon Balm, Lotus , Marigold, Medicinal Mushrooms, Mugwort, Neem, Oregano, Reishi Mushroom, Rose , Rosemary, White Mulberry , Wormwood
Diseases : Coxsackievirus Infections, Influenza, Respiratory Infections, Rhinovirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Flavonoid glycosides and alkaloids from the embryos of Nelumbo nucifera seeds and their antioxidant activity.Jan 21, 2018

Pubmed Data : Fitoterapia. 2018 Jan 22. Epub 2018 Jan 22. PMID: 29371159
Article Published Date : Jan 21, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Antioxidants, Lotus, oxidative stress
[+]

Generally used nutritional extracts of these plants have in vitro antiviral activity against rotavirus.Jul 25, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Virol J. 2012 Jul 26 ;9:137. Epub 2012 Jul 26. PMID: 22834653
Article Published Date : Jul 25, 2012
Study Type : In Vitro Study
Additional Links
Substances : Licorice, Lotus , Nettle, Olive, Rooibos
Diseases : Rotavirus Infections
Pharmacological Actions : Antiviral Agents
Additional Keywords : Antiviral Agents, Licorice, Lotus, Natural Substance Synergy, nettle, Olive, Plant Extracts, Rooibos, Rotavirus Infections
[+]

Hyperoside and rutin from lotus roots may be the promising candidates for treatment of colon cancer.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2016 Apr ;11(4):2463-2470. Epub 2016 Feb 18. PMID: 27073499
Article Published Date : Mar 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus , Rutin
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation
[+]

Inhibitory effect on SARS-CoV-2 infection of neferine by blocking Ca 2+ -dependent membrane fusion.May 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Virol. 2021 Jun 1. Epub 2021 Jun 1. PMID: 34061377
Article Published Date : May 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Isoliensinine could efficiently induce apoptosis in triple-negative breast cancer cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2015 ;5:12579. Epub 2015 Jul 29. PMID: 26219228
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic
[+]

Korean white lotus has antioxidant and antiproliferative activity against human pulmonary cancer and human gastric cancer cell lines. Oct 01, 2009

Pubmed Data : J Med Food. 2009 Oct;12(5):1057-64. PMID: 19857070
Article Published Date : Oct 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Gastric Cancer, Lung Cancer
Pharmacological Actions : Antioxidants, Antiproliferative
[+]

Lotus contains anti-HIV compounds.Jan 17, 2005

Pubmed Data : Bioorg Med Chem. 2005 Jan 17;13(2):443-8. PMID: 15598565
Article Published Date : Jan 17, 2005
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : HIV Infections
Pharmacological Actions : Anti-HIV Agents
[+]

Lotus extract inhibits Herpes simplex virus type 1 propagation. Sep 01, 2004

Pubmed Data : Gynecol Oncol. 2004 Sep;94(3):760-8. PMID: 16132118
Article Published Date : Sep 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : HSV-1
Pharmacological Actions : Antiviral Agents
Additional Keywords : Plant Extracts
[+]

Lotus has hepatoprotective and free radical scavenging effects. Mar 01, 2003

Pubmed Data : Phytomedicine. 2003 Mar;10(2-3):165-9. PMID: 12725571
Article Published Date : Mar 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Chemically-Induced Liver Damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
[+]

Lotus is a potential herbal candidate for the therapy of cardiovascular diseases associated with endothelial dysfunction and atherosclerosis.Jan 31, 2019

Pubmed Data : J Nanosci Nanotechnol. 2019 Feb 1 ;19(2):1176-1179. PMID: 30360228
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Atherosclerosis, Cardiovascular Diseases, Endothelial Dysfunction
Pharmacological Actions : Cardioprotective, Vasodilator Agents
[+]

Lotus leaf alcohol extract inhibits the cell migration and metastasis of ER- breast cancer.Feb 17, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Metab (Lond). 2021 Feb 18 ;18(1):20. Epub 2021 Feb 18. PMID: 33602253
Article Published Date : Feb 17, 2021
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

Lotus leaf extract might be useful for treatment in therapy-resistance triple negative breast cancer.Jul 20, 2016

Pubmed Data : J Ethnopharmacol. 2016 Jul 21 ;188:111-22. Epub 2016 May 10. PMID: 27178635
Article Published Date : Jul 20, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Plant Extracts
[+]

Lotus leaf extracts could be potential therapeutic agents for prevention of photoaging-related disorders.Jul 31, 2016

Pubmed Data : J Photochem Photobiol B. 2016 Aug ;161:211-6. Epub 2016 Apr 12. PMID: 27262853
Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Ultraviolet Radiation Induced Damage
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Photoprotective
Additional Keywords : Plant Extracts
[+]

Lotus leaf flavonoids had potential to be as an ingredient in functional food for the prevention of type-2 diabetes.Sep 05, 2018

Pubmed Data : Int J Biol Macromol. 2018 Sep 6. Epub 2018 Sep 6. PMID: 30195612
Article Published Date : Sep 05, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Diabetes Mellitus: Type 2: Prevention
Pharmacological Actions : Enzyme Inhibitors: Pancreatic Amylase
[+]

Lotus leaf flavonoids induce apoptosis of human lung cancer A549 cells.Mar 01, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Res. 2021 Mar 2 ;54(1):7. Epub 2021 Mar 2. PMID: 33653412
Article Published Date : Mar 01, 2021
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Lotus
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Lotus rhizome and seed extract may stimulate immunity. Mar 24, 2010

Pubmed Data : J Ethnopharmacol. 2010 Mar 24;128(2):490-4. Epub 2010 Jan 14. PMID: 20079418
Article Published Date : Mar 24, 2010
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Immune Disorders: Low Immune Function
Pharmacological Actions : Immunomodulatory
[+]

Lotus root might potentially improve neural function through the stimulation of BDNF production in glial cells.May 08, 2017

Pubmed Data : J Diet Suppl. 2017 May 9:1-13. Epub 2017 May 9. PMID: 28485986
Article Published Date : May 08, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Pharmacological Actions : Brain-derived neurotrophic factor modulator, Heme oxygenase-1 up-regulation
Additional Keywords : Brain-derived neurotrophic factor modulator, Heme oxygenase-1 up-regulation, Lotus, Plant Extracts
[+]

Lotus seed epicarp could be exploited as a potential source of natural antioxidants and α-amylase inhibitors.Jul 23, 2018

Pubmed Data : Appl Biochem Biotechnol. 2018 Jul 24. Epub 2018 Jul 24. PMID: 30039473
Article Published Date : Jul 23, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Pharmacological Actions : Alpha-amylase inhibitor, Antioxidants
[+]

Lotus seed protein isolate exerts anti-inflammatory and antioxidant effects in LPS-stimulated RAW264.7 macrophages.May 17, 2019

Pubmed Data : Int J Biol Macromol. 2019 May 18 ;134:791-797. Epub 2019 May 18. PMID: 31112732
Article Published Date : May 17, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Lotus seedpod extract inhibits cell proliferation and induces apoptosis in non-small cell lung cancer cells via downregulation of Axl.Dec 30, 2020

Pubmed Data : J Food Biochem. 2020 Dec 31:e13601. Epub 2020 Dec 31. PMID: 33381866
Article Published Date : Dec 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Apoptotic
[+]

Lotus seedpod extracts reduced lipid accumulation and lipotoxicity in hepatocytes.Nov 27, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Nov 28 ;11(12). Epub 2019 Nov 28. PMID: 31795130
Article Published Date : Nov 27, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Apoptotic, Hepatoprotective, Hypolipidemic
[+]

Lotus seedpod proanthocyanidins protect against neurotoxicity after methyl-mercuric chloride injury.Nov 14, 2019

Pubmed Data : Ecotoxicol Environ Saf. 2019 Nov 15 ;183:109560. Epub 2019 Aug 14. PMID: 31421536
Article Published Date : Nov 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
Additional Keywords : Proanthocyanidins
Problem Substances : Mercury
[+]

Lotus stamen has antioxidant properties.Apr 01, 2003

Pubmed Data : Arch Pharm Res. 2003 Apr;26(4):279-85. PMID: 12735685
Article Published Date : Apr 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Kaempferol, Lotus
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Lotusine pre-treatment has exhibited potential cardioprotective activity against doxorubicin-induced oxidative stress.Apr 30, 2020

Pubmed Data : In Vitro Cell Dev Biol Anim. 2020 May ;56(5):367-377. Epub 2020 May 29. PMID: 32468412
Article Published Date : Apr 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Anti-Apoptotic, Cardioprotective, Chemoprotective Agents
[+]

N. nucifera leaves can be used as potential preventative therapies against angiogenesis-related diseases.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(2):e0118552. Epub 2015 Feb 25. PMID: 25714482
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Pharmacological Actions : Anti-Angiogenic, Antioxidants, Antiproliferative
Additional Keywords : Plant Extracts
[+]

N. nucifera possesses potent cholinesterases and BACE1-inhibitory activities.May 31, 2015

Pubmed Data : Arch Pharm Res. 2015 Jun ;38(6):1178-87. Epub 2014 Oct 11. PMID: 25300425
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Cholinesterase Inhibitors
Additional Keywords : Plant Extracts
[+]

Neferine ameliorates cardiomyoblast apoptosis induced by doxorubicin.Sep 24, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Sep 25 ;7(1):12283. Epub 2017 Sep 25. PMID: 28947826
Article Published Date : Sep 24, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Chemoprotective Agents
Additional Keywords : Anti-Inflammatory Agents, Cardioprotective, Chemoprotective Agents, Lotus
[+]

Neferine and isoliensinine enhance intracellular uptake of cisplatin and induce ROS-mediated apoptosis in colorectal cancer cells.Jun 26, 2019

Pubmed Data : Food Chem Toxicol. 2019 Jun 27 ;132:110652. Epub 2019 Jun 27. PMID: 31255669
Article Published Date : Jun 26, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Colorectal Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Neferine attenuates the protein level and toxicity of mutant huntingtin in PC-12 cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2015 ;20(3):3496-514. Epub 2015 Feb 18. PMID: 25699594
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Huntington Disease, Neurodegenerative Diseases
Pharmacological Actions : Anti-Apoptotic, Autophagy Up-regulation, Neuroprotective Agents
[+]

Neferine augments the therapeutic efficacy of cisplatin in human lung adenocarcinoma cells.Apr 30, 2017

Pubmed Data : Food Chem Toxicol. 2017 May ;103:28-40. Epub 2017 Feb 20. PMID: 28223119
Article Published Date : Apr 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Lung Cancer
Pharmacological Actions : Autophagy Up-regulation, Chemotherapeutic
Additional Keywords : Autophagy Up-regulation, Chemotherapeutic, Chemotherapeutic Synergy: Cisplatin, Lotus, lung cancer
[+]

Neferine can prevent UV-B induced oxidative damage and may thus be a potential agent for prevention and treatment of skin damage and photoaging.Mar 12, 2018

Pubmed Data : J Dermatolog Treat. 2018 Mar 13:1-27. Epub 2018 Mar 13. PMID: 29532689
Article Published Date : Mar 12, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Ultraviolet Radiation Induced Damage
Pharmacological Actions : Antioxidants, Photoprotective
[+]

Neferine could be a potential therapeutic application for against osteolytic bone conditions such as osteoporosis.May 23, 2019

Pubmed Data : J Cell Physiol. 2019 May 24. Epub 2019 May 24. PMID: 31127627
Article Published Date : May 23, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Osteoprotective
[+]

Neferine could be beneficial in the early treatment of atherosclerosis to prevent stroke and heart disease.Dec 31, 2017

Pubmed Data : Pharmazie. 2018 09 1 ;73(9):541-544. PMID: 30223939
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Atherosclerosis, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Neferine enhances oxaliplatin sensitivity through an inhibition of EMT in liver cancer cells.Jan 29, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Jan 30 ;7:41616. Epub 2017 Jan 30. PMID: 28134289
Article Published Date : Jan 29, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Liver Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemosensitizer, Chemotherapeutic Synergy: Oxaliplatin, liver cancer, Lotus
[+]

Neferine enhances the antitumor effect of mitomycin-c in hela cells.Mar 21, 2017

Pubmed Data : J Cell Biochem. 2017 Mar 22. Epub 2017 Mar 22. PMID: 28328092
Article Published Date : Mar 21, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Apoptotic, Cervical Cancer, Chemotherapeutic Synergy: Mitomycin C, Lotus
[+]

Neferine from Nelumbo nucifera induces autophagy in A549 cells.Dec 14, 2013

Pubmed Data : Food Chem. 2013 Dec 15 ;141(4):3598-605. Epub 2013 Jun 7. PMID: 23993526
Article Published Date : Dec 14, 2013
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
Additional Keywords : Plant Extracts
[+]

Neferine has strong antioxidative and photoprotective properties.Dec 20, 2018

Pubmed Data : Biosci Rep. 2018 Dec 21 ;38(6). Epub 2018 Dec 14. PMID: 30355644
Article Published Date : Dec 20, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Aging Skin, Oxidative Stress, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Antioxidants, Matrix metalloproteinase-1 (MMP-1) inhibitor, Photoprotective
[+]

Neferine hinders choriocarcinoma cell proliferation, migration and invasion through repression of long noncoding RNA-CHRF.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Artif Cells Nanomed Biotechnol. 2019 Dec ;47(1):4089-4096. PMID: 31630562
Article Published Date : Nov 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Choriocarcinoma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

Neferine improves oxidative stress and apoptosis in benign prostate hyperplasia via Nrf2-ARE pathway.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Redox Rep. 2021 Dec ;26(1):1-9. PMID: 33416009
Article Published Date : Nov 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Prostatic Hyperplasia: Benign
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma.Aug 31, 2020

Pubmed Data : Oncol Rep. 2020 Sep ;44(3):1116-1126. Epub 2020 Jul 7. PMID: 32705225
Article Published Date : Aug 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Esophageal Cancer
Pharmacological Actions : Apoptotic
[+]

Neferine induces autophagy-dependent cell death in apoptosis-resistant cancers.Dec 26, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 Dec 27 ;9(1):20034. Epub 2019 Dec 27. PMID: 31882989
Article Published Date : Dec 26, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cancers: All, Cancers: Drug Resistant
Pharmacological Actions : Autophagy Up-regulation, Chemotherapeutic
[+]

Neferine inhibits growth and migration of gastrointestinal stromal tumor cell line GIST-T1.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:1951-1959. Epub 2018 Nov 26. PMID: 30551450
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Gastrointestinal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, MicroRNA modulator
[+]

Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis.Jun 05, 2019

Pubmed Data : Inflamm Res. 2019 Jun 6. Epub 2019 Jun 6. PMID: 31172209
Article Published Date : Jun 05, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Chronic Kidney Disease (CKD), Endothelial Dysfunction
Pharmacological Actions : Antioxidants
[+]

Neferine inhibits MDA-MB-231 cells growth and metastasis by regulating miR-374a/FGFR-2.Jun 14, 2019

Pubmed Data : Chem Biol Interact. 2019 Jun 15 ;309:108716. Epub 2019 Jun 15. PMID: 31207222
Article Published Date : Jun 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative , MicroRNA modulator
[+]

Neferine inhibits proliferation and migration of human prostate cancer stem cells.May 10, 2020

Pubmed Data : J Food Biochem. 2020 May 11:e13253. Epub 2020 May 11. PMID: 32394497
Article Published Date : May 10, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Cancer Stem Cells
[+]

Neferine inhibits proliferation, migration and invasion of U251 glioma cellsDec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:1032-1040. Epub 2018 Nov 6. PMID: 30551353
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Glioma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

Neferine is a potential treatment for type 2 diabetes.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:999. Epub 2019 Sep 4. PMID: 31551792
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents
[+]

Neferine is a promising pharmacotherapy for osteoarthritis.Jun 01, 2020

Pubmed Data : Inflammation. 2020 Jun 2. Epub 2020 Jun 2. PMID: 32488683
Article Published Date : Jun 01, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Osteoprotective
[+]

Neferine may be a potential candidate molecule in the treatment of proliferative vitreoretinopathy.May 31, 2020

Pubmed Data : Cutan Ocul Toxicol. 2020 Jun ;39(2):97-105. Epub 2020 Mar 9. PMID: 32064963
Article Published Date : May 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Retinal Detachment
Pharmacological Actions : Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, P21 Activation
[+]

Neferine may be explored as a promising antitumoral agent in ovarian cancer.Jan 06, 2016

Pubmed Data : Tumour Biol. 2016 Jan 7. Epub 2016 Jan 7. PMID: 26738868
Article Published Date : Jan 06, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Autophagy Up-regulation
[+]

Neferine may be used as prophylactic agent against the hypoxic challenge.Jul 07, 2016

Pubmed Data : Biofactors. 2016 Jul 8 ;42(4):407-17. Epub 2016 Apr 4. PMID: 27041079
Article Published Date : Jul 07, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Hypoxia, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Cytoprotective, Prophylactic Agents
[+]

Neferine may serve as a therapeutic candidate for obesity treatment.Jun 21, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Jun 22 ;12(6). Epub 2020 Jun 22. PMID: 32580414
Article Published Date : Jun 21, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents
[+]

Neferine might be a potential candidate against human neuroblastoma cells.Nov 27, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Nov 28 ;23(12). Epub 2018 Nov 28. PMID: 30486505
Article Published Date : Nov 27, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Neuroblastoma
Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation, Cell cycle arrest
[+]

Neferine might be a promising natural compound to potentiate imatinib in CML patients.Mar 31, 2019

Pubmed Data : J Food Sci. 2019 Apr ;84(4):904-910. Epub 2019 Mar 13. PMID: 30866043
Article Published Date : Mar 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cancers: Drug Resistant, Chronic Myeloid Leukemia
Pharmacological Actions : Antineoplastic Agents, Apoptotic
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Neferine prevented hyperglycemia-induced endothelial cell apoptosis.Nov 30, 2014

Pubmed Data : Endocrine. 2014 Dec ;47(3):764-71. Epub 2014 Mar 4. PMID: 24590293
Article Published Date : Nov 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Hyperglycemia, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, NF-kappaB Inhibitor
[+]

Neferine prevents ultraviolet radiation-induced skin photoaging. Apr 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2020 May ;19(5):3189-3196. Epub 2020 Mar 9. PMID: 32266014
Article Published Date : Apr 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Photooxidative Stress, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Antioxidants, Photoprotective
[+]

Neferine promotes the apoptosis of HNSCC through the accumulation of p62/SQSTM1 caused by autophagic flux inhibition.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2021 07 ;48(1). Epub 2021 May 13. PMID: 33982791
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Head and Neck Cancer
Pharmacological Actions : Apoptotic
[+]

Neferine reduces cisplatin-induced nephrotoxicity by enhancing autophagy.Mar 10, 2017

Pubmed Data : Biochem Biophys Res Commun. 2017 Mar 11 ;484(3):694-701. Epub 2017 Feb 1. PMID: 28161641
Article Published Date : Mar 10, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Autophagy Up-regulation, Chemoprotective Agents
Additional Keywords : Autophagy Up-regulation, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Lotus
[+]

Neferine reduces the cisplatin dose requirement in cancer chemotherapy.Feb 17, 2017

Pubmed Data : J Cell Biochem. 2017 Feb 18. Epub 2017 Feb 18. PMID: 28214344
Article Published Date : Feb 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Apoptotic, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin, Lotus, lung cancer, Vascular Endothelial Growth Factor Inhibitors
[+]

Neferine revealed higher toxicity toward paclitaxel and doxorubicin-resistant breast, lung or colon cancer cells.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2017 ;8:238. Epub 2017 May 5. PMID: 28529482
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Breast Cancer, Cancers: Multi-Drug Resistant, Colon Cancer, Lung Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Breast Cancer, Cancers: Multi-Drug Resistant, Chemosensitizer, Chemotherapeutic, COLON CANCER, Lotus, lung cancer
[+]

Neferine sensitized Taxol-resistant nasopharygeal carcinoma to taxol.Oct 21, 2020

Pubmed Data : Biochem Biophys Res Commun. 2020 Oct 22 ;531(4):573-580. Epub 2020 Aug 15. PMID: 32811645
Article Published Date : Oct 21, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Chemosensitizer, MicroRNA modulator
[+]

Neferine suppresses autophagy-induced inflammation, oxidative stress and adipocyte differentiation in Graves' orbitopathy.Jan 13, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2021 Jan 14. Epub 2021 Jan 14. PMID: 33443817
Article Published Date : Jan 13, 2021
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Graves Disease
Pharmacological Actions : Anti-Adipogenic, Anti-Inflammatory Agents, Antioxidants, Nrf2 activation
[+]

Neferine suppresses diethylnitrosamine-induced lung carcinogenesis in Wistar rats.Nov 09, 2018

Pubmed Data : Food Chem Toxicol. 2018 Nov 10 ;123:385-398. Epub 2018 Nov 10. PMID: 30423403
Article Published Date : Nov 09, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Lung Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

Neferine targets HeLa and SiHa cervical cancer cells.May 03, 2020

Pubmed Data : Phytother Res. 2020 May 4. Epub 2020 May 4. PMID: 32364634
Article Published Date : May 03, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
[+]

Neferine treatment enhances the TRAIL-induced apoptosis of human prostate cancer cells.Apr 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2020 May ;56(5):1152-1161. Epub 2020 Mar 13. PMID: 32319589
Article Published Date : Apr 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic
[+]

Neferine, a compound found within the lotus, reverses multidrug resistance in human gastric cancer cells. Oct 15, 2004

Pubmed Data : World J Gastroenterol. 2004 Oct 15;10(20):3062-4. PMID: 15378795
Article Published Date : Oct 15, 2004
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cancers: Multi-Drug Resistant, Gastric Cancer
Additional Keywords : Disease Reversal
[+]

Neferine-induced apoptosis is dependent on the suppression of Bcl-2 expression via downregulation of p65 in renal cancer cells.Jun 11, 2019

Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2019 Jun 12. Epub 2019 Jun 12. PMID: 31187116
Article Published Date : Jun 11, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Kidney Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Nelumbo leaf extracts can ameliorate disease conditions involving chronic inflammation.Jul 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Res Pract. 2017 Aug ;11(4):265-274. Epub 2017 Jul 21. PMID: 28765772
Article Published Date : Jul 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Inflammatory Agents, Inflammation, Lotus
[+]

Nelumbo nucifera extract suppresses angiotensin II-induced cardiomyocyte hypertrophy.Apr 25, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Apr 26 ;24(9). Epub 2019 Apr 26. PMID: 31027372
Article Published Date : Apr 25, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Nelumbo nucifera leaf polyphenol extract and gallic acid inhibit TNF-α-induced vascular smooth muscle cell proliferation and migration.Oct 20, 2020

Pubmed Data : Food Funct. 2020 Oct 21 ;11(10):8602-8611. PMID: 33084700
Article Published Date : Oct 20, 2020
Study Type : In Vitro Study
Additional Links
Substances : Gallic Acid, Lotus , Polyphenols
Diseases : Atherosclerosis
Pharmacological Actions : MicroRNA modulator
[+]

Nelumbo nucifera leaves prevent NMU-induced mammary tumor.Dec 31, 2018

Pubmed Data : Am J Chin Med. 2019 ;47(8):1885-1899. PMID: 31838869
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Breast Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Nelumbo nucifera leaves protect against hydrogen peroxide-induced hepatic damage.May 31, 2015

Pubmed Data : Food Funct. 2015 Jun ;6(6):1911-8. PMID: 25962859
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Chemically-Induced Liver Damage, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

Nelumbo nucifera seed may be of use in the treatment and prevention of neurodegenerative disorders.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2014 ;2014:869831. Epub 2014 Dec 24. PMID: 25610484
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cognitive Decline/Dysfunction, Memory Disorders: Drug-Induced
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Neuroprotective effects of lotus seedpod procyanidins on extremely low frequency electromagnetic field-induced neurotoxicity.Jul 31, 2016

Pubmed Data : Biomed Pharmacother. 2016 Aug ;82:628-39. Epub 2016 Jun 13. PMID: 27470406
Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : DNA damage, Electromagnetic Radiation Mitigation
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Bcl-2 protein down-regulation, Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation
Additional Keywords : Proanthocyanidins
Anti Therapeutic Actions : Electromagnetic Field Harms
[+]

Nuciferine could be a potential chemical applicated in the therapy of laryngeal squamous cell carcinoma.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Tohoku J Exp Med. 2021 ;254(1):17-23. PMID: 34011804
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Chemopreventive
[+]

Nuciferine improves high-fat diet-induced obesity.Jul 04, 2021

Pubmed Data : Food Funct. 2021 Jul 5 ;12(13):5850-5861. PMID: 34018523
Article Published Date : Jul 04, 2021
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Obesity
Pharmacological Actions : Autophagy Up-regulation, Gastrointestinal Agents
Additional Keywords : Anti-Obesity Agents
[+]

Nuciferine inhibited the differentiation and lipid accumulation of 3T3-L1 preadipocytes.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:632236. Epub 2021 Mar 22. PMID: 33841152
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Dyslipidemias, Obesity
Pharmacological Actions : Hypolipidemic
Additional Keywords : Anti-Obesity Agents, Gene Expression Regulation
[+]

Nuciferine inhibits proinflammatory cytokines via the PPARs in LPS-induced RAW264.7 cells.Oct 21, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Oct 22 ;23(10). Epub 2018 Oct 22. PMID: 30360404
Article Published Date : Oct 21, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Nuciferine inhibits skin cutaneous melanoma cell growth by suppressing TLR4/NF-κB signalling.Aug 09, 2020

Pubmed Data : Anticancer Agents Med Chem. 2020 Aug 10. Epub 2020 Aug 10. PMID: 32781974
Article Published Date : Aug 09, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Melanoma
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Nuciferine inhibits the progression of glioblastoma.Mar 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2019 Mar 29 ;38(1):139. Epub 2019 Mar 29. PMID: 30922391
Article Published Date : Mar 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Nuciferine prevents bone loss by disrupting multinucleated osteoclast formation and promoting type H vessel formation.Feb 29, 2020

Pubmed Data : FASEB J. 2020 Mar ;34(3):4798-4811. Epub 2020 Feb 10. PMID: 32039519
Article Published Date : Feb 29, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Osteoarthritis
Pharmacological Actions : Osteoprotective
[+]

Phenolic rich ethyl acetate fractions from lotus leaves have great potential to be used against oxidative stress-induced health conditions.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Prev Nutr Food Sci. 2015 Mar ;20(1):22-8. Epub 2015 Mar 31. PMID: 25866746
Article Published Date : Feb 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Cytoprotective
Additional Keywords : Plant Extracts
[+]

Plumula nelumbinis: A review of traditional uses, phytochemistry, pharmacology, pharmacokinetics and safety.Sep 30, 2020

Pubmed Data : J Ethnopharmacol. 2020 Oct 1:113429. Epub 2020 Oct 1. PMID: 33011369
Article Published Date : Sep 30, 2020
Study Type : Review
Additional Links
Substances : Lotus
Diseases : Cardiovascular Diseases, Hypertension, Kidney Damage, Liver Damage
Pharmacological Actions : Antihypertensive Agents, Antioxidants, Cardioprotective, Hepatoprotective, Renoprotective
[+]

Polysaccharide derived from Nelumbo nucifera lotus shows potential prebiotic activity and ameliorates insulin resistance in HepG2 cells.May 27, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Polymers (Basel). 2021 May 28 ;13(11). Epub 2021 May 28. PMID: 34071638
Article Published Date : May 27, 2021
Study Type : In Vitro Study
Additional Links
Substances : Lotus , Prebiotics
Diseases : Insulin Resistance
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Polysaccharides
[+]

Polysaccharides isolated from lotus leaves exert anti-osteoporotic effects.Jun 08, 2020

Pubmed Data : Int J Biol Macromol. 2020 Jun 9 ;161:449-456. Epub 2020 Jun 9. PMID: 32531355
Article Published Date : Jun 08, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
Additional Keywords : Polysaccharides
[+]

Procyanidins from lotus seedpod induced autophagy and autophagic cell death in HepG2 cells.Mar 31, 2016

Pubmed Data : Biomed Pharmacother. 2016 Apr ;79:135-52. Epub 2016 Feb 22. PMID: 27044822
Article Published Date : Mar 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Liver Cancer
Pharmacological Actions : Autophagy Up-regulation
Additional Keywords : Dose Response, Procyanidins
[+]

Protective effect of Nelumbo nucifera (Gaertn.) against H2O2-induced oxidative stress on H9c2 cardiomyocytes.Dec 10, 2019

Pubmed Data : Mol Biol Rep. 2019 Dec 11. Epub 2019 Dec 11. PMID: 31823124
Article Published Date : Dec 10, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Protective effect of Nelumbo nucifera extracts on beta amyloid protein induced apoptosis in PC12 cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Food Drug Anal. 2018 Jan ;26(1):172-181. Epub 2017 Mar 17. PMID: 29389553
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Quercetin-3-O-β-d-glucuronide from lotus leaves could significantly inhibit LPS-induced NO release in vitro in a dose-dependent manner.Dec 31, 2016

Pubmed Data : J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 1 ;1040:186-191. Epub 2016 Dec 12. PMID: 27987489
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Anti-Inflammatory Agents, Dose Response, Inflammation, Lipopolysaccharide-Induced Toxicity, Lotus
[+]

The cytoprotective and anti-cancer potential of bisbenzylisoquinoline alkaloids from Nelumbo nucifera.Nov 15, 2019

Pubmed Data : Curr Top Med Chem. 2019 Nov 16. Epub 2019 Nov 16. PMID: 31738137
Article Published Date : Nov 15, 2019
Study Type : Review
Additional Links
Substances : Lotus
Diseases : Chemotherapy and Radiation Toxicity, Diabetes Mellitus: Type 2, Stroke: Ischemic
Pharmacological Actions : Chemoprotective Agents, Chemosensitizer, Neuroprotective Agents
[+]

The Effect of sacred lotus and its mixtures on phenolic profiles, antioxidant activities, and inhibitions of the key enzymes relevant to Alzheimer's disease.Aug 13, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Aug 14 ;25(16). Epub 2020 Aug 14. PMID: 32824050
Article Published Date : Aug 13, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

The findings of this study provide evidences that the inedible lotus seedpod could be a source for natural antioxidants and anticancer agents.Aug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Sci Nutr. 2019 Sep ;7(9):3062-3070. Epub 2019 Aug 9. PMID: 31572599
Article Published Date : Aug 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus , Polyphenols
Diseases : Liver Cancer, Prostate Cancer
Pharmacological Actions : Antioxidants, Antiproliferative
[+]

The flavonoid C-glycosides of lotus seed embryos had higher antioxidant properties than the flavonoid O-glycosides presented in lotus leaves.Jun 19, 2017

Pubmed Data : J Food Sci. 2017 Jun 20. Epub 2017 Jun 20. PMID: 28631810
Article Published Date : Jun 19, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

The results of this study suggest the role of neferine in preventing hypoxia induced autophagy in muscle cells.Sep 30, 2016

Pubmed Data : Biomed Pharmacother. 2016 Oct ;83:1407-1413. Epub 2016 Aug 29. PMID: 27583981
Article Published Date : Sep 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Hypoxia, Muscle Damage
Pharmacological Actions : Antioxidants, Autophagy Inhibitors, Cytoprotective, NF-E2-Related Factor-2 (Nrf2) Modulator
[+]

These data suggested that liensinine might represent a novel and effective agent against gastric cancer.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer. 2019 ;10(25):6431-6438. Epub 2019 Oct 19. PMID: 31772676
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

These findings suggest that polysaccharides extracted from lotus leaf exert immunostimulatory activity.Apr 30, 2019

Pubmed Data : Int J Biol Macromol. 2019 May 1 ;128:546-555. Epub 2019 Jan 25. PMID: 30685309
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Pharmacological Actions : Immunostimulatory
Additional Keywords : Polysaccharides
[+]

These findings suggested that Neferine could be a new treatment or adjuvant against retinoblastoma.May 27, 2020

Pubmed Data : Exp Biol Med (Maywood). 2020 May 28:1535370220928933. Epub 2020 May 28. PMID: 32460625
Article Published Date : May 27, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Retinoblastoma
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative
[+]

These observations reveal that the therapeutic potential of neferine in treating HCC Hep3B cells, containing copies of hepatitis B virus genomes.Aug 14, 2013

Pubmed Data : Phytomedicine. 2013 Aug 15 ;20(11):1013-22. Epub 2013 Jun 6. PMID: 23746959
Article Published Date : Aug 14, 2013
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Liver Cancer
Pharmacological Actions : Anti-Angiogenic, Apoptotic, Cell cycle arrest
Additional Keywords : Phytotherapy, Plant Extracts
[+]

These results suggested the potential of neferine as a therapeutic agent for acute respiratory distress syndrome.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Physiol. 2018 ;9:102. Epub 2018 Feb 22. PMID: 29520236
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Acute Respiratory Distress Syndrome, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents
[+]

These results validate the traditional use of Nelumbo Nucifera leaves for the management of diabetes.Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Tradit Chin Med. 2016 Feb ;36(1):71-7. PMID: 26946622
Article Published Date : Jan 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic, Insulin-releasing, Interleukin-1 beta downregulation
Additional Keywords : Plant Extracts
[+]

This study suggests the use of neferine for amelioration of doxorubicin -mediated cardiotoxicity.Jul 20, 2017

Pubmed Data : J Cell Biochem. 2017 Jul 21. Epub 2017 Jul 21. PMID: 28731223
Article Published Date : Jul 20, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Cardioprotective, Chemoprotective Agents
Additional Keywords : Cardioprotective, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Doxorubicin, Lotus

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