Lotus

Name	AC	CK
Oxidative Stress	18	27
Obesity	11	20
Inflammation	8	11
High Fat Diet	5	10
Liver Cancer	7	10
Lung Cancer	8	10
Memory Disorders	5	10
Alzheimer's Disease	6	9
Diabetes Mellitus: Type 2	5	8
Lipopolysaccharide-Induced Toxicity	7	8
Hypoxia	3	7
Lipid Peroxidation	4	7
Aging: Brain	3	6
Endothelial Dysfunction	4	6
Ultraviolet Radiation Induced Damage	5	6
Aging	3	5
Cognitive Decline/Dysfunction	3	5
Gastric Cancer	4	5
Atherosclerosis	4	4
Cancers: Drug Resistant	3	4
Chemically-Induced Liver Damage	3	4
Depression	2	4
Diabetes: Cataract	2	4
Liver Fibrosis	2	4
Sleep Disorders	2	4
Ulcerative Colitis	2	4
Breast Cancer	3	3
Breast Cancer: Triple Negative	3	3
Carcinoma: Non-Small-Cell Lung	2	3
Chemotherapy-Induced Toxicity: Doxorubicin	3	3
Colon Cancer	3	3
Diabetes Mellitus: Type 1	2	3
Hypertension	2	3
Kidney Damage	2	3
Nonalcoholic fatty liver disease (NAFLD)	2	3
Osteoarthritis	3	3
Ovarian Cancer	2	3
Prostate Cancer	3	3
Stroke: Ischemic	2	3
Aluminum Toxicity	1	2
Anxiety	1	2
Anxiety Disorders	1	2
Arteriosclerosis	1	2
Asthma	1	2
Brain Damage	1	2
Cancers: All	2	2
Cancers: Multi-Drug Resistant	2	2
Cardiovascular Diseases	2	2
Cervical Cancer	2	2
Chemotherapy-Induced Toxicity: Cisplatin	2	2
Diabetes: Cognitive Dysfunction	1	2
Diabetes: Glycation/A1C	1	2
Diabetic Complications	1	2
Diabetic Nephropathy	1	2
Diabetic Ulcer	1	2
Epilepsy	1	2
Fever	1	2
HIV Infections	2	2
Hepatic Steatosis	1	2
Hyperuricemia	1	2
Insulin Resistance	1	2
Learning disorders	1	2
Liver Cirrhosis	1	2
Lupus Erythematosus: Systemic	1	2
Myocardial Fibrosis	1	2
Nasopharyngeal Cancer	2	2
Neurodegeneration: Dentate Gyrus	1	2
Neuropathic Pain	1	2
Nicotine/Tobacco Toxicity	1	2
Prostatic Hyperplasia: Benign	2	2
Seizures	1	2
Squamous cell carcinoma	1	2
Triglycerides: Elevated	1	2
Wound Healing	1	2
Acute Respiratory Distress Syndrome	1	1
Aging Skin	1	1
Cardiac Hypertrophy	1	1
Chemotherapy and Radiation Toxicity	1	1
Choriocarcinoma	1	1
Chronic Kidney Disease (CKD)	1	1
Chronic Myeloid Leukemia	1	1
Colorectal Cancer	1	1
Coxsackievirus Infections	1	1
DNA damage	1	1
Diabetes Mellitus: Type 2: Prevention	1	1
Dyslipidemias	1	1
Electromagnetic Radiation Mitigation	1	1
Esophageal Cancer	1	1
Gastrointestinal Cancer	1	1
Glioblastoma	1	1
Glioma	1	1
Graves Disease	1	1
HSV-1	1	1
Huntington Disease	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Hyperglycemia	1	1
Immune Disorders: Low Immune Function	1	1
Influenza	1	1
Kidney Cancer	1	1
Liver Damage	1	1
Melanoma	1	1
Memory Disorders: Drug-Induced	1	1
Muscle Damage	1	1
Neuroblastoma	1	1
Neurodegenerative Diseases	1	1
Oral Cancer	1	1
Osteoporosis	1	1
Photooxidative Stress	1	1
Respiratory Infections	1	1
Restenosis	1	1
Retinal Detachment	1	1
Retinoblastoma	1	1
Rhinovirus Infection	1	1
Rotavirus Infections	1	1

Name	AC	CK
Antioxidants	44	65
Anti-Inflammatory Agents	26	41
Apoptotic	23	25
Neuroprotective Agents	16	25
Antiproliferative	21	24
Tumor Necrosis Factor (TNF) Alpha Inhibitor	13	24
Hepatoprotective	11	18
Interleukin-6 Downregulation	9	17
NF-kappaB Inhibitor	11	15
Interleukin-1 beta downregulation	8	13
Anti-Apoptotic	10	11
Nrf2 activation	7	10
Autophagy Up-regulation	9	9
Cardioprotective	8	9
Chemosensitizer	8	9
Chemoprotective Agents	7	8
Cyclooxygenase 2 Inhibitors	6	8
Cytoprotective	4	8
Hypoglycemic Agents	5	8
Superoxide Dismutase Up-regulation	5	8
Hypolipidemic	5	7
Malondialdehyde Down-regulation	4	7
Renoprotective	4	7
Anti-metastatic	6	6
Interleukin-8 downregulation	2	6
Photoprotective	5	6
Chemotherapeutic	4	5
Immunomodulatory	3	5
Aldose reductase inhibitor	2	4
Angiogenesis Inhibitors	3	4
Anticarcinogenic Agents	3	4
Antidepressive Agents	2	4
Bcl-2 protein down-regulation	4	4
Chemopreventive	3	4
Heme oxygenase-1 up-regulation	4	4
MicroRNA modulator	4	4
Osteoprotective	4	4
Antihypertensive Agents	2	3
Antiviral Agents	3	3
Cell cycle arrest	3	3
Matrix metalloproteinase-2 (MMP-2) inhibitor	3	3
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	3
Neuritogenic	2	3
Vasodilator Agents	2	3
Analgesics	1	2
Anti-Angiogenic	2	2
Anti-Anxiety Agents	1	2
Anti-Fibrotic	1	2
Anti-Ulcer Agents	1	2
Anti-pyretic	1	2
Anticholesteremic Agents	1	2
Anticonvulsants	1	2
Anxiolytic	1	2
Bax/Bcl2 Ratio: Decrease	1	2
Cytotoxic	1	2
GABA Modulators	1	2
Gastrointestinal Agents	1	2
Histamine Antagonists	1	2
Hypnotics and Sedatives	1	2
Interleukin-10 upregulation	1	2
Neurogenesis	1	2
Nitric Oxide Inhibitor	1	2
Sedative effects	1	2
Vascular Cell Adhesion Molecule-1 Inhibitor	1	2
Vascular Endothelial Growth Factor Inhibitors	2	2
Wnt/β-catenin pathway down-regulation	1	2
Acetylcholinesterase Inhibitor	1	1
Alpha-amylase inhibitor	1	1
Anti-Adipogenic	1	1
Anti-HIV Agents	1	1
Anti-Retroviral Agents	1	1
Antimicrobial	1	1
Antineoplastic Agents	1	1
Autophagy Inhibitors	1	1
Bcl-xL down-regulation	1	1
Brain-derived neurotrophic factor modulator	1	1
Caspase-3 Activation	1	1
Caspase-8 activation	1	1
Caspase-9 Activation	1	1
Catalase Up-Regulation	1	1
Cholinesterase Inhibitors	1	1
Enzyme Inhibitors: Pancreatic Amylase	1	1
Immunostimulatory	1	1
Insulin-releasing	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
NF-E2-Related Factor-2 (Nrf2) Modulator	1	1
P21 Activation	1	1
Postaglandin PGE2 downregulation	1	1
Prophylactic Agents	1	1

[+]

Fat reducing effects of Nelumbo nucifera leaf extract in overweight patients.Dec 01, 2021

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Pubmed Data : Nat Prod Res. 2021 Dec 2:1-6. Epub 2021 Dec 2. PMID: 34852695

Article Published Date : Dec 01, 2021

Study Type : Human Study

Additional Links

Substances : Lotus

Diseases : Overweight

Pharmacological Actions : Hypolipidemic

Additional Keywords : Anti-Obesity Agents

[+]

Neferine exerts a cytoprotective effect against hypoxia-induced oxidative stress and inflammation in human peripheral blood mononuclear cells.Jul 08, 2017

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Pubmed Data : Biomed Pharmacother. 2017 Jul 9 ;93:730-736. Epub 2017 Jul 9. PMID: 28700977

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Pubmed Data : Pharmaceuticals (Basel). 2022 Jan 10 ;15(1). Epub 2022 Jan 10. PMID: 35056140

Article Published Date : Jan 09, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Lotus

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Extracts from Nelumbo nucifera leaves had significantly hepatoprotective effect for Calcium tetrachloride CCl4-induced liver injury.Dec 31, 2013

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Pubmed Data : Afr J Tradit Complement Altern Med. 2014 ;11(3):85-91. Epub 2014 Apr 3. PMID: 25371567

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Pubmed Data : J Agric Food Chem. 2010 Jun 9;58(11):7075-81. PMID: 20481471

Article Published Date : Jun 09, 2010

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Lotus

Diseases : Obesity

Additional Keywords : Anti-Obesity Agents, Plant Extracts

[+]

Lotus has antipyretic properties.Jun 01, 2000

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Pubmed Data : Phytother Res. 2000 Jun;14(4):272-4. PMID: 10861971

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Pubmed Data : Biosci Biotechnol Biochem. 2008 Feb;72(2):477-84. Epub 2008 Feb 7. PMID: 16495025

Article Published Date : Feb 01, 2008

Study Type : Animal Study

Additional Links

Substances : Lotus

Diseases : Obesity

Additional Keywords : Anti-Obesity Agents, Plant Extracts

[+]

Lotus procyanidins reverse memory impairments in cognitivitely impaired aged rats.Sep 01, 2010

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Pubmed Data : J Gerontol A Biol Sci Med Sci. 2010 Sep;65(9):933-40. Epub 2010 Jun 7. PMID: 20530246

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Pubmed Data : Biomed Pharmacother. 2016 Aug ;82:640-8. Epub 2016 Jun 13. PMID: 27470407

Pubmed Data : Food Funct. 2013 Aug ;4(8):1252-62. PMID: 23764910

Article Published Date : Aug 01, 2013

Pubmed Data : Cancer Lett. 2018 Sep 28 ;432:144-155. Epub 2018 Jun 5. PMID: 29879497

Article Published Date : Sep 27, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Lotus

Diseases : Ovarian Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Chemotherapeutic

[+]

Neferine may have antifibrogenic effects in diabetes-related cardiac fibrosis.Sep 19, 2016

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Pubmed Data : Oncotarget. 2016 Sep 20 ;7(38):61703-61715. PMID: 27533252

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Pubmed Data : Environ Toxicol. 2017 Aug 14. Epub 2017 Aug 14. PMID: 28804948

Article Published Date : Aug 13, 2017

Study Type : Animal Study

Additional Links

Substances : Lotus

Diseases : Liver Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antioxidants

[+]

Nelumbo nucifera leaves extract attenuate the pathological progression of diabetic nephropathy.Jun 30, 2019

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Pubmed Data : J Food Drug Anal. 2019 Jul ;27(3):736-748. Epub 2019 Jan 8. PMID: 31324289

Article Published Date : Jun 30, 2019

Study Type : Animal Study

Additional Links

Substances : Lotus

Diseases : Diabetic Nephropathy, High Fat Diet

Pharmacological Actions : Antioxidants, Nrf2 activation, Renoprotective

[+]

Click here to read the entire abstract

Pubmed Data : Br J Pharmacol. 2018 Nov ;175(22):4218-4228. Epub 2018 Oct 11. PMID: 30129056

Article Published Date : Oct 31, 2018

Study Type : Animal Study

Additional Links

Substances : Lotus

Diseases : Diabetes Mellitus: Type 2, Hepatic Steatosis

Pharmacological Actions : Anticholesteremic Agents, Antioxidants, Hepatoprotective

[+]

Nuciferine modulates the gut microbiota and prevents obesity in high-fat diet-fed rats.Jan 11, 2020

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Pubmed Data : Exp Mol Med. 2020 12 ;52(12):1959-1975. Epub 2020 Dec 1. PMID: 33262480

Article Published Date : Jan 11, 2020

Study Type : Animal Study

Additional Links

Substances : Lotus

Diseases : High Fat Diet, Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents

Additional Keywords : Anti-Obesity Agents

[+]

Nuciferine not only inhibited the growth of NSCLC cells, but also remarkably alleviated the injury induced by nicotine in liver function.May 12, 2015

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Pubmed Data : J Ethnopharmacol. 2015 May 13 ;165:83-93. Epub 2015 Feb 16. PMID: 25698245

Article Published Date : May 12, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Lotus

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer, Nicotine/Tobacco Toxicity

Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 Ratio: Decrease, Hepatoprotective, Wnt/β-catenin pathway down-regulation

[+]

Procyanidins extracted from lotus seedpod ameliorate amyloid-β-induced toxicity in rat pheochromocytoma cells.Dec 31, 2017

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Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:4572893. Epub 2018 Oct 28. PMID: 30538801

Article Published Date : Dec 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Lotus

Diseases : Alzheimer's Disease

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

Additional Keywords : Plant Extracts, Proanthocyanidins

[+]

Procyanidins extracted from the lotus seedpod ameliorate scopolamine-induced memory impairment in mice.Jan 13, 2010

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Pubmed Data : Phytother Res. 2010 Jan 13. Epub 2010 Jan 13. PMID: 19367674

Article Published Date : Jan 13, 2010

Study Type : Animal Study

Additional Links

Substances : Lotus

Diseases : Memory Disorders

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts, Proanthocyanidins

[+]

Protection against dextran sulfate sodium-induced ulcerative colitis in mice by neferine.Dec 31, 2020

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Pubmed Data : Cell J. 2021 Jan ;22(4):523-531. Epub 2020 Apr 22. PMID: 32347046

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Lotus

Diseases : Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2017 May 17 ;65(19):3801-3810. Epub 2017 May 8. PMID: 28314100

Article Published Date : May 16, 2017

Study Type : Animal Study

Additional Links

Substances : Lotus

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic

Additional Keywords : Plant Extracts, Proanthocyanidins

Problem Substances : Insulin

[+]

Vasorelaxant and antihypertensive effects of neferine.Apr 30, 2020

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Pubmed Data : Planta Med. 2020 May ;86(7):496-504. Epub 2020 Mar 27. PMID: 32219782

Article Published Date : Apr 30, 2020

Study Type : Animal Study

Additional Links

Substances : Lotus

Diseases : Endothelial Dysfunction, Hypertension

Pharmacological Actions : Antihypertensive Agents, Vasodilator Agents

[+]

Water-soluble polysaccharides from lotus seeds can be used as an antitumor and immunomodulatory agent.Nov 01, 2016

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Pubmed Data : J Adv Pharm Technol Res. 2020 Oct-Dec;11(4):174-178. Epub 2020 Oct 10. PMID: 33425700

Article Published Date : Sep 30, 2020

Study Type : In Vitro Study

Additional Links

Substances : Gotu Kola, Hibiscus sabdariffa , Lotus

Diseases : Aging

[+]

Anti-allergic and anti-inflammatory effects of neferine on RBL-2H3 cells. Oct 11, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2021 Oct 12 ;22(20). Epub 2021 Oct 12. PMID: 34681651

Article Published Date : Oct 11, 2021

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Atopic Dermatitis

Pharmacological Actions : Anti-Allergic Agents, Anti-Inflammatory Agents

[+]

Anti-inflammatory effects of fermented lotus root and linoleic acid in lipopolysaccharide-induced RAW 264.7 cells.Nov 18, 2020

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Pubmed Data : J Med Food. 2009 Oct;12(5):1057-64. PMID: 19857070

Article Published Date : Oct 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Gastric Cancer, Lung Cancer

Pharmacological Actions : Antioxidants, Antiproliferative

[+]

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2010 Mar 24;128(2):490-4. Epub 2010 Jan 14. PMID: 20079418

Article Published Date : Mar 24, 2010

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Immune Disorders: Low Immune Function

Pharmacological Actions : Immunomodulatory

[+]

Lotus root might potentially improve neural function through the stimulation of BDNF production in glial cells.May 08, 2017

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Pubmed Data : J Diet Suppl. 2017 May 9:1-13. Epub 2017 May 9. PMID: 28485986

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Pubmed Data : J Food Biochem. 2020 Dec 31:e13601. Epub 2020 Dec 31. PMID: 33381866

Article Published Date : Dec 30, 2020

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Apoptotic

[+]

Lotus seedpod extracts reduced lipid accumulation and lipotoxicity in hepatocytes.Nov 27, 2019

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Pubmed Data : Nutrients. 2019 Nov 28 ;11(12). Epub 2019 Nov 28. PMID: 31795130

Article Published Date : Nov 27, 2019

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Apoptotic, Hepatoprotective, Hypolipidemic

[+]

Lotus seedpod proanthocyanidins protect against neurotoxicity after methyl-mercuric chloride injury.Nov 14, 2019

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Pubmed Data : Ecotoxicol Environ Saf. 2019 Nov 15 ;183:109560. Epub 2019 Aug 14. PMID: 31421536

Article Published Date : Nov 14, 2019

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation

Additional Keywords : Proanthocyanidins

Problem Substances : Mercury

[+]

Lotus stamen has antioxidant properties.Apr 01, 2003

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Pubmed Data : Arch Pharm Res. 2003 Apr;26(4):279-85. PMID: 12735685

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Pubmed Data : Arch Pharm Res. 2015 Jun ;38(6):1178-87. Epub 2014 Oct 11. PMID: 25300425

Article Published Date : May 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Cholinesterase Inhibitors

Additional Keywords : Plant Extracts

[+]

Neferine ameliorates cardiomyoblast apoptosis induced by doxorubicin.Sep 24, 2017

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Pubmed Data : Food Chem Toxicol. 2017 May ;103:28-40. Epub 2017 Feb 20. PMID: 28223119

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Pubmed Data : Redox Rep. 2021 Dec ;26(1):1-9. PMID: 33416009

Article Published Date : Nov 30, 2021

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Prostatic Hyperplasia: Benign

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

[+]

Neferine increases sensitivities to multiple anticancer drugs via downregulation of Bcl-2 expression in renal cancer cells.Jan 15, 2022

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Pubmed Data : Genes Genomics. 2022 Jan 16. Epub 2022 Jan 16. PMID: 35034280

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Pubmed Data : J Environ Pathol Toxicol Oncol. 2021 ;40(3):51-61. PMID: 34587404

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Breast Cancer, Breast Cancer: Chemically-Induced

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Neferine inhibits growth and migration of gastrointestinal stromal tumor cell line GIST-T1.Dec 31, 2018

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Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:1032-1040. Epub 2018 Nov 6. PMID: 30551353

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Glioma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

[+]

Neferine is a potential treatment for type 2 diabetes.Dec 31, 2018

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Pubmed Data : Molecules. 2018 Nov 28 ;23(12). Epub 2018 Nov 28. PMID: 30486505

Article Published Date : Nov 27, 2018

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Neuroblastoma

Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation, Cell cycle arrest

[+]

Neferine might be a promising natural compound to potentiate imatinib in CML patients.Mar 31, 2019

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Pubmed Data : J Food Sci. 2019 Apr ;84(4):904-910. Epub 2019 Mar 13. PMID: 30866043

Article Published Date : Mar 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Cancers: Drug Resistant, Chronic Myeloid Leukemia

Pharmacological Actions : Antineoplastic Agents, Apoptotic

Additional Keywords : Chemothapeutic Synergy: Imatinib

[+]

Click here to read the entire abstract

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Pubmed Data : Front Pharmacol. 2017 ;8:238. Epub 2017 May 5. PMID: 28529482

Additional Keywords : Anti-Inflammatory Agents, Inflammation, Lotus

[+]

Nelumbo nucifera extract suppresses angiotensin II-induced cardiomyocyte hypertrophy.Apr 25, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

[+]

Nuciferine inhibits proinflammatory cytokines via the PPARs in LPS-induced RAW264.7 cells.Oct 21, 2018

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Pubmed Data : Molecules. 2018 Oct 22 ;23(10). Epub 2018 Oct 22. PMID: 30360404

Article Published Date : Oct 21, 2018

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Nuciferine inhibits skin cutaneous melanoma cell growth by suppressing TLR4/NF-κB signalling.Aug 09, 2020

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Pubmed Data : Anticancer Agents Med Chem. 2020 Aug 10. Epub 2020 Aug 10. PMID: 32781974

Article Published Date : Aug 09, 2020

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Melanoma

Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2016 Apr ;79:135-52. Epub 2016 Feb 22. PMID: 27044822

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Pubmed Data : J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 1 ;1040:186-191. Epub 2016 Dec 12. PMID: 27987489

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Anti-Inflammatory Agents, Dose Response, Inflammation, Lipopolysaccharide-Induced Toxicity, Lotus

[+]

Reversal of cisplatin resistance by neferine/isoliensinine and their combinatorial regimens with cisplatin-induced apoptosis in cisplatin-resistant colon cancer stem cells.Dec 16, 2021

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Pubmed Data : J Biochem Mol Toxicol. 2021 Dec 17:e22967. Epub 2021 Dec 17. PMID: 34921482

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These results suggested the potential of neferine as a therapeutic agent for acute respiratory distress syndrome.Dec 31, 2017

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Pubmed Data : Front Physiol. 2018 ;9:102. Epub 2018 Feb 22. PMID: 29520236

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Acute Respiratory Distress Syndrome, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents

[+]

These results validate the traditional use of Nelumbo Nucifera leaves for the management of diabetes.Jan 31, 2016

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Pubmed Data : J Tradit Chin Med. 2016 Feb ;36(1):71-7. PMID: 26946622

Article Published Date : Jan 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Diabetes Mellitus: Type 1

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic, Insulin-releasing, Interleukin-1 beta downregulation

Additional Keywords : Plant Extracts

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Fat reducing effects of Nelumbo nucifera leaf extract in overweight patients.Dec 01, 2021

Neferine exerts a cytoprotective effect against hypoxia-induced oxidative stress and inflammation in human peripheral blood mononuclear cells.Jul 08, 2017

A compound found within Lotus flower may positively modulate immune function in autoimmune disease like systemic lupus erythematosus. Feb 15, 2006

A dietary supplement of nuciferine rich in lotus leaf may have potential for the prevention and treatment of hyperuricemia with kidney inflammation.Jan 14, 2015

A multiple-targets alkaloid nuciferine overcomes paclitaxel-induced drug resistance in vitro and in vivo.Sep 09, 2020

Alkaloids extracted from lotus leaves might be a new complementary treatment to treat abnormal contractions of the trachea and asthma.Mar 19, 2017

An combined extract of lotus, white mulberry and radish may be a natural anti-obesity agent.May 18, 2019

Anti-obesity and antidiabetic effects of nelumbinis semen powder in high-fat diet-induced obese.Nov 21, 2020

Anti-obesity effects of a Prunus persica and Nelumbo nucifera mixture in mice fed a high-fat diet.Nov 03, 2020

Antioxidant and inflammatory effects of Nelumbo nucifera leaves.Dec 31, 2020

Chemomodulatory effect of neferine on DMBA-induced squamous cell carcinogenesis.Nov 05, 2020

Effects of Nelumbo nucifera leaf extract on obesity. Aug 31, 2021

Evaluation of antiinflammatory activity of ethanol extract of Nelumbo nucifera fruit.Feb 24, 2021

Extracellular vesicle delivery of neferine for the attenuation of neurodegenerative disease proteins.Jan 09, 2022

Extracts from Nelumbo nucifera leaves had significantly hepatoprotective effect for Calcium tetrachloride CCl4-induced liver injury.Dec 31, 2013

GABA contained in lotus seed extract acts as a sleep potentiating compound.Feb 28, 2021

Isoliensinine from Nelumbo nucifera induces hepatocellular carcinoma cell apoptosis.Oct 13, 2015

Long-term intake of the lotus seed tea showed the effect of preventing loss of skin moisture, mitigating the formation of abnormal keratinocytes.Aug 31, 2015

Lotus flower leaf has anti-obesity effects in mice.Jun 09, 2010

Lotus has antipyretic properties.Jun 01, 2000

Lotus has immunomodulatory effects. Jan 05, 2010

Lotus leaf hot water extract with taurine supplementation showed antiobesity and hypolipidemic effects in high fat diet-induced obese rats.Jun 23, 2006

Lotus leaves have an anti-obesity effect in mice. Feb 01, 2008

Lotus procyanidins reverse memory impairments in cognitivitely impaired aged rats.Sep 01, 2010

Lotus root extract with taurine has an antioxidant and hepatoprotective effect in rats fed a high fat diet.Jan 01, 2010

Lotus seed extract has a hypoglycemic effect in diabetic rats.Nov 01, 2004

Lotus seed extract improves memory in cognitively impaired aged rats.Dec 01, 2009

Lotus seed procyanidins prevent oxidative stress by extremely low frequency electromagnetic fields in mice.Aug 01, 2016

Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway.Dec 31, 2018

Lotus seedpod proanthyocyanins have an ameliorative effect on cognitive deficits and oxidative damage in senescence-accelerated mice.Dec 01, 2008

Lotus seedpod procyanidins mitigate the oxidative effects and learning and memory damage caused by extremely low frequency electromagnetic fields onAug 01, 2013

Lotus stamen has aldose reductase inhibitory which may have value in preventing diabetes-associated eye damage. Oct 01, 2006

N. nucifera extract is the potential neuroprotective and memory enhancing agent. Dec 31, 2015

N. nucifera fruit exhibited strong anxiolytic and antidepressant effects.Jan 31, 2017

N. nucifera fruit may be valuable in managing epilepsy.Aug 02, 2017

Neferine alleviates memory and cognitive dysfunction in diabetes.Jun 30, 2020

Neferine alleviates neuropathic pain by downregulating the expression of P2X3 receptor.Aug 31, 2020

Neferine ameliorates dextran sulfate sodium-induced ulcerative colitis.Dec 31, 2017

Neferine exerted remarkable protection against cerebral ischemia.Sep 07, 2021

Neferine extracted from Lotus seed has sedative anti-anxiety effects.Dec 01, 2008

Neferine had an antifibrosis effect on carbon tetrachloride-induced hepatic fibrosis in mice.Dec 31, 2014

Neferine is an attractive reagent with great potential in high-grade serous ovarian carcinoma therapy.Sep 27, 2018

Neferine may have antifibrogenic effects in diabetes-related cardiac fibrosis.Sep 19, 2016

Neferine may serve as an effective regulator during the pathogenesis of vascular inflammatory diseases.Jan 14, 2020

Neferine might have therapeutic potential for ischaemic stroke Nov 09, 2018

Neferine mitigated renal injury in acute kidney injury models.Dec 31, 2018

Neferine protects against hypoxic-ischemic brain damage.Dec 31, 2020

Neferine significantly promotes a fast and efficient wound healing.Nov 30, 2020

Neferine, a compound extracted from Nulembo nucifera, has a similar effect to rosiglitazone (Avandia) in decreasing fasting blood glucose, insulin, TG, TNF-alpha and enhancing insulin sensitivity in insulin resistant rats.Jul 06, 2009

Neferine, an alkaloid from lotus seed embryos, exerts antiseizure and neuroprotective effects.Apr 07, 2022

Nelumbo nucifera contains a compound which exhibits vitro and in vivo antifibrotic effects in rats with liver fibrosis. Sep 02, 2009

Nelumbo nucifera extract exhibits anti-atherogenic activity by inhibiting the proliferation and migration of vascular smooth muscle cells in an animal model of atherosclerosis. Sep 30, 2009

Nelumbo nucifera fruit seems to have great potential for therapeutic application in memory disorders.Sep 30, 2018

Nelumbo nucifera improves memory and neurogenesis in the dentate gyrus of the rat hippocampusOct 03, 2008

Nelumbo nucifera leaf extract treatment attenuated preneoplastic lesions and oxidative stress in the livers of diethylnitrosamine-treated rats.Aug 13, 2017

Nelumbo nucifera leaves extract attenuate the pathological progression of diabetic nephropathy.Jun 30, 2019

Nelumbo nucifera leaves have a therapeutic effect on rat lens aldose reductase, advanced glycation endproduct formation and oxidative stress. Dec 01, 2008

Nelumbo nucifera seed extract promotes sleep in drosophila melanogaster.Dec 31, 2017

Nootropic effect of neferine on aluminium chloride-induced Alzheimer's disease in experimental models. Jan 31, 2020

Nuciferine could treat obesity through modulating gut microbiota, decreasing gut permeability and ameliorating inflammation.Mar 31, 2021

Nuciferine from Nelumbo nucifera Gaertn. attenuates isoproterenol-induced myocardial infarction.May 15, 2021

Nuciferine may be a potentially important candidate in improving hepatic steatosis and the management of T2DM.Oct 31, 2018

Nuciferine modulates the gut microbiota and prevents obesity in high-fat diet-fed rats.Jan 11, 2020

Nuciferine not only inhibited the growth of NSCLC cells, but also remarkably alleviated the injury induced by nicotine in liver function.May 12, 2015

Procyanidins extracted from lotus seedpod ameliorate amyloid-β-induced toxicity in rat pheochromocytoma cells.Dec 31, 2017

Procyanidins extracted from the lotus seedpod ameliorate scopolamine-induced memory impairment in mice.Jan 13, 2010

Protection against dextran sulfate sodium-induced ulcerative colitis in mice by neferine.Dec 31, 2020

Protective effects of lotus plumule ethanol extracts on bleomycin-induced pulmonary fibrosis.Nov 01, 2021

The mixture of Eriobotrya japonica and Nelumbo nucifera extract may strongly regulate body weight gain.Dec 31, 2014

These results indicate that neferine has good potential as an alternative medicine for the treatment of atopic dermatitis.Jul 29, 2021

This provides a new theoretical basis for Nelumbo nucifera Gaertn stem as an antidepressant-like agent.Dec 31, 2019

This study demonstrated an amelioration of the metabolic disorders following nuciferine treatment in NAFLD.Dec 31, 2019

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202 Abstracts with Lotus Research