Lotus

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82 Diseases Researched for Lotus
NameACCKFocus
Oxidative Stress1217Locked
Obesity612Locked
Memory Disorders510Locked
Liver Cancer69Locked
Lung Cancer78Locked
Hypoxia37Locked
Inflammation67Locked
Aging: Brain 36Locked
Diabetes Mellitus: Type 236Locked
Cognitive Decline/Dysfunction35Locked
Lipopolysaccharide-Induced Toxicity55Locked
Ultraviolet Radiation Induced Damage45Locked
Aging24Locked
Chemically-Induced Liver Damage34Locked
Diabetes: Cataract24Locked
Gastric Cancer34Locked
Liver Fibrosis24Locked
Alzheimer's Disease23Locked
Atherosclerosis33Locked
Colon Cancer33Locked
Diabetes Mellitus: Type 123Locked
Lipid Peroxidation23Locked
Ovarian Cancer23Locked
Anxiety12Locked
Anxiety Disorders12Locked
Arteriosclerosis12Locked
Asthma12Locked
Brain Damage12Locked
Breast Cancer: Triple Negative 22Locked
Cancers: Multi-Drug Resistant22Locked
Carcinoma: Non-Small-Cell Lung12Locked
Chemotherapy-Induced Toxicity: Cisplatin22Locked
Chemotherapy-Induced Toxicity: Doxorubicin22Locked
Depression12Locked
Diabetes: Glycation/A1C12Locked
Diabetic Complications12Locked
Endothelial Dysfunction22Locked
Epilepsy12Locked
Fever12Locked
HIV Infections22Locked
Hepatic Steatosis12Locked
High Fat Diet12Locked
Hyperuricemia12Locked
Insulin Resistance12Locked
Liver Cirrhosis12Locked
Lupus Erythematosus: Systemic12Locked
Myocardial Fibrosis 12Locked
Neurodegeneration: Dentate Gyrus12Locked
Nicotine/Tobacco Toxicity 12Locked
Seizures12Locked
Sleep Disorders12Locked
Stroke: Ischemic12Locked
Triglycerides: Elevated12Locked
Ulcerative Colitis12Locked
Acute Respiratory Distress Syndrome11Locked
Aging Skin11Locked
Breast Cancer11Locked
Cancers: All11Locked
Cancers: Drug Resistant11Locked
Cardiac Hypertrophy11Locked
Cardiovascular Diseases11Locked
Cervical Cancer11Locked
Chronic Kidney Disease (CKD)11Locked
Chronic Myeloid Leukemia11Locked
Diabetes Mellitus: Type 2: Prevention11Locked
Gastrointestinal Cancer11Locked
Glioma11Locked
HSV-111Locked
Huntington Disease11Locked
Hyperglycemia11Locked
Immune Disorders: Low Immune Function11Locked
Kidney Cancer11Locked
Memory Disorders: Drug-Induced11Locked
Muscle Damage11Locked
Nasopharyngeal Cancer11Locked
Neuroblastoma11Locked
Neurodegenerative Diseases11Locked
Oral Cancer11Locked
Osteoarthritis11Locked
Prostatic Hyperplasia: Benign11Locked
Restenosis11Locked
Rotavirus Infections11Locked
80 Pharmacological Actions Researched for Lotus
NameACCKFocus
Antioxidants3045Locked
Anti-Inflammatory Agents1319Locked
Apoptotic1618Locked
Neuroprotective Agents915Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor815Locked
Antiproliferative 1114Locked
Hepatoprotective712Locked
Interleukin-6 Downregulation611Locked
NF-kappaB Inhibitor810Locked
Cytoprotective48Locked
Autophagy Up-regulation77Locked
Hypoglycemic Agents47Locked
Cardioprotective56Locked
Interleukin-8 downregulation26Locked
Cyclooxygenase 2 Inhibitors45Locked
Hypolipidemic35Locked
Immunomodulatory35Locked
Interleukin-1 beta downregulation45Locked
Photoprotective45Locked
Aldose reductase inhibitor 24Locked
Anti-Apoptotic44Locked
Anticarcinogenic Agents34Locked
Chemoprotective Agents44Locked
Chemosensitizer44Locked
Chemotherapeutic34Locked
Angiogenesis Inhibitors23Locked
Anti-metastatic33Locked
Bcl-2 protein down-regulation33Locked
Nrf2 activation23Locked
Superoxide Dismutase Up-regulation23Locked
Anti-Angiogenic22Locked
Anti-Anxiety Agents12Locked
Anti-Fibrotic12Locked
Anti-pyretic 12Locked
Anticholesteremic Agents12Locked
Anticonvulsants12Locked
Antidepressive Agents12Locked
Antiviral Agents22Locked
Anxiolytic12Locked
Bax/Bcl2 Ratio: Decrease12Locked
Cell cycle arrest22Locked
Cytotoxic12Locked
Heme oxygenase-1 up-regulation22Locked
Histamine Antagonists12Locked
Hypnotics and Sedatives12Locked
Malondialdehyde Down-regulation12Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor22Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor22Locked
Neuritogenic12Locked
Neurogenesis12Locked
Nitric Oxide Inhibitor12Locked
Renoprotective12Locked
Sedative effects12Locked
Vascular Endothelial Growth Factor Inhibitors22Locked
Wnt/β-catenin pathway down-regulation12Locked
Acetylcholinesterase Inhibitor11Locked
Alpha-amylase inhibitor11Locked
Anti-HIV Agents11Locked
Anti-Retroviral Agents11Locked
Antimicrobial11Locked
Antineoplastic Agents11Locked
Autophagy Inhibitors11Locked
Bcl-xL down-regulation11Locked
Brain-derived neurotrophic factor modulator11Locked
Caspase-3 Activation11Locked
Caspase-8 activation11Locked
Caspase-9 Activation11Locked
Catalase Up-Regulation11Locked
Chemopreventive11Locked
Cholinesterase Inhibitors11Locked
Enzyme Inhibitors: Pancreatic Amylase11Locked
Immunostimulatory11Locked
Insulin-releasing11Locked
Matrix metalloproteinase-1 (MMP-1) inhibitor11Locked
MicroRNA modulator11Locked
NF-E2-Related Factor-2 (Nrf2) Modulator11Locked
Osteoprotective 11Locked
Postaglandin PGE2 downregulation 11Locked
Prophylactic Agents11Locked
Vasodilator Agents11Locked

View the Evidence:
155 Abstracts with Lotus Research

[+]

Neferine exerts a cytoprotective effect against hypoxia-induced oxidative stress and inflammation in human peripheral blood mononuclear cells.Jul 08, 2017

Pubmed Data : Biomed Pharmacother. 2017 Jul 9 ;93:730-736. Epub 2017 Jul 9. PMID: 28700977
Article Published Date : Jul 08, 2017
Study Type : Human In Vitro
Additional Links
Substances : Lotus
Diseases : Hypoxia, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cytoprotective, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

A compound found within Lotus flower may positively modulate immune function in autoimmune disease like systemic lupus erythematosus. Feb 15, 2006

Pubmed Data : Eur J Pharmacol. 2006 Feb 15;531(1-3):270-9. Epub 2006 Jan 17. PMID: 16413531
Article Published Date : Feb 15, 2006
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Lupus Erythematosus: Systemic
[+]

A dietary supplement of nuciferine rich in lotus leaf may have potential for the prevention and treatment of hyperuricemia with kidney inflammation.Jan 14, 2015

Pubmed Data : Eur J Pharmacol. 2015 Jan 15 ;747:59-70. Epub 2014 Dec 8. PMID: 25499818
Article Published Date : Jan 14, 2015
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Hyperuricemia, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Renoprotective
[+]

A multiple-targets alkaloid nuciferine overcomes paclitaxel-induced drug resistance in vitro and in vivo.Sep 09, 2020

Pubmed Data : Phytomedicine. 2020 Sep 10 ;79:153342. Epub 2020 Sep 10. PMID: 32992085
Article Published Date : Sep 09, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cancers: Drug Resistant, Lung Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Alkaloids extracted from lotus leaves might be a new complementary treatment to treat abnormal contractions of the trachea and asthma.Mar 19, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2017 Mar 20 ;17(1):159. Epub 2017 Mar 20. PMID: 28320373
Article Published Date : Mar 19, 2017
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Asthma
Additional Keywords : Asthma, Lotus, Plant Extracts
[+]

An combined extract of lotus, white mulberry and radish may be a natural anti-obesity agent.May 18, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2019 May 19 ;8(5). Epub 2019 May 19. PMID: 31109115
Article Published Date : May 18, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus , Radish, White Mulberry
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents, Plant Extracts
[+]

Extracts from Nelumbo nucifera leaves had significantly hepatoprotective effect for Calcium tetrachloride CCl4-induced liver injury.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Afr J Tradit Complement Altern Med. 2014 ;11(3):85-91. Epub 2014 Apr 3. PMID: 25371567
Article Published Date : Dec 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Isoliensinine from Nelumbo nucifera induces hepatocellular carcinoma cell apoptosis.Oct 13, 2015

Pubmed Data : J Agric Food Chem. 2015 Oct 14 ;63(40):8793-803. Epub 2015 Oct 1. PMID: 26389520
Article Published Date : Oct 13, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor
[+]

Long-term intake of the lotus seed tea showed the effect of preventing loss of skin moisture, mitigating the formation of abnormal keratinocytes.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Prev Nutr Food Sci. 2015 Sep ;20(3):162-8. Epub 2015 Sep 30. PMID: 26451352
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Ultraviolet Radiation Induced Damage
Pharmacological Actions : Antioxidants, Photoprotective
[+]

Lotus flower leaf has anti-obesity effects in mice.Jun 09, 2010

Pubmed Data : J Agric Food Chem. 2010 Jun 9;58(11):7075-81. PMID: 20481471
Article Published Date : Jun 09, 2010
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Lotus
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents, Plant Extracts
[+]

Lotus has antipyretic properties.Jun 01, 2000

Pubmed Data : Phytother Res. 2000 Jun;14(4):272-4. PMID: 10861971
Article Published Date : Jun 01, 2000
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Fever
Pharmacological Actions : Anti-pyretic
[+]

Lotus has immunomodulatory effects. Jan 05, 2010

Pubmed Data : Psychol Med. 2010 Jan 5:1-11. Epub 2010 Jan 5. PMID: 20095810
Article Published Date : Jan 05, 2010
Study Type : Animal Study
Additional Links
Substances : Lotus
Pharmacological Actions : Histamine Antagonists, Immunomodulatory, Nitric Oxide Inhibitor
[+]

Lotus leaf hot water extract with taurine supplementation showed antiobesity and hypolipidemic effects in high fat diet-induced obese rats.Jun 23, 2006

Pubmed Data : J Biol Chem. 2006 Jun 23;281(25):17359-68. Epub 2006 Apr 17. PMID: 20804619
Article Published Date : Jun 23, 2006
Study Type : Animal Study
Additional Links
Substances : Lotus , Taurine
Diseases : Obesity
Additional Keywords : Natural Substance Synergy
[+]

Lotus leaves have an anti-obesity effect in mice. Feb 01, 2008

Pubmed Data : Biosci Biotechnol Biochem. 2008 Feb;72(2):477-84. Epub 2008 Feb 7. PMID: 16495025
Article Published Date : Feb 01, 2008
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents, Plant Extracts
[+]

Lotus procyanidins reverse memory impairments in cognitivitely impaired aged rats.Sep 01, 2010

Pubmed Data : J Gerontol A Biol Sci Med Sci. 2010 Sep;65(9):933-40. Epub 2010 Jun 7. PMID: 20530246
Article Published Date : Sep 01, 2010
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Aging, Aging: Brain , Cognitive Decline/Dysfunction, Memory Disorders
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Lotus root extract with taurine has an antioxidant and hepatoprotective effect in rats fed a high fat diet.Jan 01, 2010

Pubmed Data : J Biomed Sci. 2010;17 Suppl 1:S39. Epub 2010 Aug 24. PMID: 20804615
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Lotus , Taurine
Diseases : Obesity
Pharmacological Actions : Antioxidants, Hepatoprotective
[+]

Lotus seed extract has a hypoglycemic effect in diabetic rats.Nov 01, 2004

Pubmed Data : Carcinogenesis. 2004 Nov;25(11):2183-9. Epub 2004 Jul 15. PMID: 20165930
Article Published Date : Nov 01, 2004
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Hypoglycemic Agents
[+]

Lotus seed extract improves memory in cognitively impaired aged rats.Dec 01, 2009

Pubmed Data : Eur Neuropsychopharmacol. 2009 Dec;19(12):851-60. Epub 2009 Aug 27. PMID: 19716273
Article Published Date : Dec 01, 2009
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Aging: Brain , Cognitive Decline/Dysfunction, Memory Disorders
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Lotus seed procyanidins prevent oxidative stress by extremely low frequency electromagnetic fields in mice.Aug 01, 2016

Pubmed Data : Biomed Pharmacother. 2016 Aug ;82:640-8. Epub 2016 Jun 13. PMID: 27470407
Article Published Date : Aug 01, 2016
Study Type : Animal Study
Additional Links
Substances : Lotus , Proanthocyanidins
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Malondialdehyde Down-regulation
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation
Adverse Pharmacological Actions : Oxidant
[+]

Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway.Dec 31, 2018

Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2019 Jan 1 ;51(1):31-40. PMID: 30544155
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus , Proanthocyanidins
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Nrf2 activation
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Lotus seedpod proanthyocyanins have an ameliorative effect on cognitive deficits and oxidative damage in senescence-accelerated mice.Dec 01, 2008

Pubmed Data : Behav Brain Res. 2008 Dec 1;194(1):100-7. Epub 2008 Jul 4. PMID: 18652848
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Additional Links
Substances : Anthocyanins, Lotus
Diseases : Aging, Aging: Brain , Oxidative Stress
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Proanthocyanidins
[+]

Lotus seedpod procyanidins mitigate the oxidative effects and learning and memory damage caused by extremely low frequency electromagnetic fields onAug 01, 2013

Pubmed Data : Food Funct. 2013 Aug ;4(8):1252-62. PMID: 23764910
Article Published Date : Aug 01, 2013
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Learning disorders, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts, Proanthocyanidins
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation
Adverse Pharmacological Actions : Neurotoxic, Oxidant
[+]

Lotus stamen has aldose reductase inhibitory which may have value in preventing diabetes-associated eye damage. Oct 01, 2006

Pubmed Data : Phytother Res. 2006 Oct;20(10):825-30. PMID: 16881021
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Lotus
Diseases : Diabetes: Cataract
Pharmacological Actions : Aldose reductase inhibitor
Additional Keywords : Plant Extracts
[+]

N. nucifera extract is the potential neuroprotective and memory enhancing agent. Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:5789857. Epub 2015 Dec 8. PMID: 26858824
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Brain Damage, Memory Disorders
Pharmacological Actions : Antioxidants, Neurogenesis, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

N. nucifera fruit exhibited strong anxiolytic and antidepressant effects.Jan 31, 2017

Pubmed Data : Metab Brain Dis. 2017 Feb 1. Epub 2017 Feb 1. PMID: 28144887
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Anxiety, Depression
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
[+]

N. nucifera fruit may be valuable in managing epilepsy.Aug 02, 2017

Pubmed Data : Metab Brain Dis. 2017 Aug 3. Epub 2017 Aug 3. PMID: 28776277
Article Published Date : Aug 02, 2017
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
Additional Keywords : Anticonvulsants, epilepsy, Lotus, Natural Substances Versus Drugs
[+]

Neferine alleviates memory and cognitive dysfunction in diabetes.Jun 30, 2020

Pubmed Data : Int Immunopharmacol. 2020 Jul ;84:106559. Epub 2020 May 8. PMID: 32402951
Article Published Date : Jun 30, 2020
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetes: Cognitive Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Neferine alleviates neuropathic pain by downregulating the expression of P2X3 receptor.Aug 31, 2020

Pubmed Data : Neurosci Res. 2020 Sep 1. Epub 2020 Sep 1. PMID: 32882253
Article Published Date : Aug 31, 2020
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Neuropathic Pain
Pharmacological Actions : Analgesics
[+]

Neferine ameliorates dextran sulfate sodium-induced ulcerative colitis.Dec 31, 2017

Pubmed Data : Am J Chin Med. 2018 ;46(6):1263-1279. Epub 2018 Aug 27. PMID: 30149754
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Phytotherapy
[+]

Neferine extracted from Lotus seed has sedative anti-anxiety effects.Dec 01, 2008

Pubmed Data : Phytomedicine. 2008 Dec;15(12):1117-24. PMID: 19010651
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Anxiety Disorders, Seizures
Pharmacological Actions : Anxiolytic, Hypnotics and Sedatives
Additional Keywords : Plant Extracts
[+]

Neferine had an antifibrosis effect on carbon tetrachloride-induced hepatic fibrosis in mice.Dec 31, 2014

Pubmed Data : Am J Chin Med. 2015 ;43(2):231-40. Epub 2015 Mar 24. PMID: 25800905
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Hepatoprotective
Additional Keywords : Dose Response, Phytotherapy
[+]

Neferine is an attractive reagent with great potential in high-grade serous ovarian carcinoma therapy.Sep 27, 2018

Pubmed Data : Cancer Lett. 2018 Sep 28 ;432:144-155. Epub 2018 Jun 5. PMID: 29879497
Article Published Date : Sep 27, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus
Diseases : Ovarian Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Chemotherapeutic
[+]

Neferine may have antifibrogenic effects in diabetes-related cardiac fibrosis.Sep 19, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Sep 20 ;7(38):61703-61715. PMID: 27533252
Article Published Date : Sep 19, 2016
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetic Complications, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
Additional Keywords : Anti-Fibrotic, Cardioprotective, Diabetic Complications, Lotus, Myocardial Fibrosis
[+]

Neferine might have therapeutic potential for ischaemic stroke Nov 09, 2018

Pubmed Data : Br J Pharmacol. 2018 Nov 10. Epub 2018 Nov 10. PMID: 30414381
Article Published Date : Nov 09, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus
Diseases : Stroke: Ischemic
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Neferine mitigated renal injury in acute kidney injury models.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:1197. Epub 2019 Oct 15. PMID: 31680971
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus
Diseases : Kidney Damage
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Renoprotective
[+]

Neferine significantly promotes a fast and efficient wound healing.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Artif Cells Nanomed Biotechnol. 2020 Dec ;48(1):96-106. PMID: 31852261
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetic Ulcer, Wound Healing
Pharmacological Actions : Anti-Inflammatory Agents, Anti-Ulcer Agents
[+]

Neferine, a compound extracted from Nulembo nucifera, has a similar effect to rosiglitazone (Avandia) in decreasing fasting blood glucose, insulin, TG, TNF-alpha and enhancing insulin sensitivity in insulin resistant rats.Jul 06, 2009

Pubmed Data : J Ethnopharmacol. 2009 Jul 6;124(1):98-102. Epub 2009 Apr 11. PMID: 19527823
Article Published Date : Jul 06, 2009
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetes Mellitus: Type 2, Insulin Resistance, Triglycerides: Elevated
Pharmacological Actions : Hypoglycemic Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substances Versus Drugs
[+]

Nelumbo nucifera contains a compound which exhibits vitro and in vivo antifibrotic effects in rats with liver fibrosis. Sep 02, 2009

Pubmed Data : J Biomed Sci. 2009 Sep 2;16:78. PMID: 19723340
Article Published Date : Sep 02, 2009
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Liver Fibrosis
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Nelumbo nucifera extract exhibits anti-atherogenic activity by inhibiting the proliferation and migration of vascular smooth muscle cells in an animal model of atherosclerosis. Sep 30, 2009

Pubmed Data : Food Chem Toxicol. 2009 Sep 30. PMID: 19799955
Article Published Date : Sep 30, 2009
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Arteriosclerosis
Pharmacological Actions : Antiproliferative
[+]

Nelumbo nucifera fruit seems to have great potential for therapeutic application in memory disorders.Sep 30, 2018

Pubmed Data : Metab Brain Dis. 2018 Oct 1. Epub 2018 Oct 1. PMID: 30270417
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Alzheimer's Disease, Memory Disorders
Pharmacological Actions : Neuroprotective Agents
[+]

Nelumbo nucifera improves memory and neurogenesis in the dentate gyrus of the rat hippocampusOct 03, 2008

Pubmed Data : Neurosci Lett. 2008 Oct 3;443(2):104-7. Epub 2008 Jul 11. PMID: 18638527
Article Published Date : Oct 03, 2008
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Neurodegeneration: Dentate Gyrus
Pharmacological Actions : Neuritogenic
Additional Keywords : Hippocampus Regeneration
[+]

Nelumbo nucifera leaf extract treatment attenuated preneoplastic lesions and oxidative stress in the livers of diethylnitrosamine-treated rats.Aug 13, 2017

Pubmed Data : Environ Toxicol. 2017 Aug 14. Epub 2017 Aug 14. PMID: 28804948
Article Published Date : Aug 13, 2017
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants
[+]

Nelumbo nucifera leaves extract attenuate the pathological progression of diabetic nephropathy.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Food Drug Anal. 2019 Jul ;27(3):736-748. Epub 2019 Jan 8. PMID: 31324289
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetic Nephropathy, High Fat Diet
Pharmacological Actions : Antioxidants, Nrf2 activation, Renoprotective
[+]

Nelumbo nucifera leaves have a therapeutic effect on rat lens aldose reductase, advanced glycation endproduct formation and oxidative stress. Dec 01, 2008

Pubmed Data : Food Chem Toxicol. 2008 Dec;46(12):3818-26. Epub 2008 Oct 10. PMID: 18952135
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetes: Cataract, Diabetes: Glycation/A1C
Pharmacological Actions : Aldose reductase inhibitor , Antioxidants
[+]

Nelumbo nucifera seed extract promotes sleep in drosophila melanogaster.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2018 ;41(3):399-408. PMID: 29491217
Article Published Date : Dec 31, 2017
Study Type : Insect Study
Additional Links
Substances : Lotus
Diseases : Sleep Disorders
Pharmacological Actions : Sedative effects
[+]

Nootropic effect of neferine on aluminium chloride-induced Alzheimer's disease in experimental models. Jan 31, 2020

Pubmed Data : J Biochem Mol Toxicol. 2020 Feb ;34(2):e22429. Epub 2019 Dec 20. PMID: 31860774
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Aluminum Toxicity , Alzheimer's Disease, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Aluminum Chloride
[+]

Nuciferine may be a potentially important candidate in improving hepatic steatosis and the management of T2DM.Oct 31, 2018

Pubmed Data : Br J Pharmacol. 2018 Nov ;175(22):4218-4228. Epub 2018 Oct 11. PMID: 30129056
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetes Mellitus: Type 2, Hepatic Steatosis
Pharmacological Actions : Anticholesteremic Agents, Antioxidants, Hepatoprotective
[+]

Nuciferine not only inhibited the growth of NSCLC cells, but also remarkably alleviated the injury induced by nicotine in liver function.May 12, 2015

Pubmed Data : J Ethnopharmacol. 2015 May 13 ;165:83-93. Epub 2015 Feb 16. PMID: 25698245
Article Published Date : May 12, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer, Nicotine/Tobacco Toxicity
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 Ratio: Decrease, Hepatoprotective, Wnt/β-catenin pathway down-regulation
[+]

Procyanidins extracted from lotus seedpod ameliorate amyloid-β-induced toxicity in rat pheochromocytoma cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:4572893. Epub 2018 Oct 28. PMID: 30538801
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lotus
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Procyanidins extracted from the lotus seedpod ameliorate scopolamine-induced memory impairment in mice.Jan 13, 2010

Pubmed Data : Phytother Res. 2010 Jan 13. Epub 2010 Jan 13. PMID: 19367674
Article Published Date : Jan 13, 2010
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Memory Disorders
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Protection against dextran sulfate sodium-induced ulcerative colitis in mice by neferine.Dec 31, 2020

Pubmed Data : Cell J. 2021 Jan ;22(4):523-531. Epub 2020 Apr 22. PMID: 32347046
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The mixture of Eriobotrya japonica and Nelumbo nucifera extract may strongly regulate body weight gain.Dec 31, 2014

Pubmed Data : Am J Chin Med. 2015 ;43(4):681-94. Epub 2015 Jul 1. PMID: 26133751
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Loquat, Lotus
Diseases : High Fat Diet, Obesity
Pharmacological Actions : Hypolipidemic
Additional Keywords : Anti-Obesity Agents, Dose Response, Natural Substance Synergy
[+]

This provides a new theoretical basis for Nelumbo nucifera Gaertn stem as an antidepressant-like agent.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:3056954. Epub 2020 Mar 30. PMID: 32308703
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
[+]

This study demonstrated an amelioration of the metabolic disorders following nuciferine treatment in NAFLD.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:858. Epub 2020 Jun 9. PMID: 32581811
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Treatments with lotus seedpod oligomeric procyanidins could be beneficial in diabetic treatments.May 16, 2017

Pubmed Data : J Agric Food Chem. 2017 May 17 ;65(19):3801-3810. Epub 2017 May 8. PMID: 28314100
Article Published Date : May 16, 2017
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic
Additional Keywords : Plant Extracts, Proanthocyanidins
Problem Substances : Insulin
[+]

Vasorelaxant and antihypertensive effects of neferine.Apr 30, 2020

Pubmed Data : Planta Med. 2020 May ;86(7):496-504. Epub 2020 Mar 27. PMID: 32219782
Article Published Date : Apr 30, 2020
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Endothelial Dysfunction, Hypertension
Pharmacological Actions : Antihypertensive Agents, Vasodilator Agents
[+]

Water-soluble polysaccharides from lotus seeds can be used as an antitumor and immunomodulatory agent.Nov 01, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2016 Nov 2 ;21(11). Epub 2016 Nov 2. PMID: 27827862
Article Published Date : Nov 01, 2016
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Gastric Cancer, Liver Cancer
Pharmacological Actions : Antioxidants, Antiproliferative , Cytotoxic, Immunomodulatory, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
Additional Keywords : Natural Substances Versus Drugs, Polysaccharides
[+]

A comprehensive review of the benefits of neferine.Feb 26, 2018

Pubmed Data : Life Sci. 2018 Feb 27. Epub 2018 Feb 27. PMID: 29499283
Article Published Date : Feb 26, 2018
Study Type : Review
Additional Links
Substances : Lotus
Diseases : Cancers: All, Chemotherapy-Induced Toxicity: Cisplatin, HIV Infections, Inflammation
Pharmacological Actions : Anti-Retroviral Agents, Antimicrobial, Antiproliferative , Apoptotic, Chemoprotective Agents, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Alkaloids from the Ba lotus seed have anticancer activity through inducing cellular apoptosis.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Nov ;12(5):3113-3120. Epub 2016 Sep 20. PMID: 27882126
Article Published Date : Oct 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

An alkaloid rich fraction from Nelumbo nucifera targets VSMC proliferation and migration to attenuate neo-intima formation.Mar 20, 2016

Pubmed Data : Atherosclerosis. 2016 Mar 21 ;248:179-189. Epub 2016 Mar 21. PMID: 27018542
Article Published Date : Mar 20, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Atherosclerosis, Restenosis
Pharmacological Actions : Antiproliferative , Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

An extract of Lotus may be a powerful agent against colon cancer cells.Feb 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2017 Mar ;13(3):1470-1478. Epub 2016 Dec 28. PMID: 28454279
Article Published Date : Feb 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
Additional Keywords : Apoptotic, Bcl-2 protein down-regulation, COLON CANCER, Lotus, Plant Extracts
[+]

Anticariogenic activity of Nelumbo nucifera leaf extract in oral healthcare.May 06, 2019

Pubmed Data : Technol Health Care. 2019 May 7. Epub 2019 May 7. PMID: 31127738
Article Published Date : May 06, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Oral Cancer
Pharmacological Actions : Anticarcinogenic Agents
[+]

Antioxidant, cholinesterase inhibition activities and essential oil analysis of Nelumbo nucifera seeds.May 31, 2016

Pubmed Data : Nat Prod Res. 2016 Jun ;30(11):1335-8. Epub 2015 Jul 27. PMID: 26212099
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Lotus
Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants
Additional Keywords : Essential Oils
[+]

Blood-brain barrier-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells.Nov 08, 2019

Pubmed Data : J Nat Med. 2019 Nov 9. Epub 2019 Nov 9. PMID: 31707550
Article Published Date : Nov 08, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuritogenic
Additional Keywords : Blood Brain Barrier
[+]

Botanical formulation HX109 ameliorates TP-induced benign prostate hyperplasia. Dec 06, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Dec 7 ;10(12). Epub 2018 Dec 7. PMID: 30544543
Article Published Date : Dec 06, 2018
Study Type : In Vitro Study
Additional Links
Substances : Dandelion , Lotus
Diseases : Prostatic Hyperplasia: Benign
Additional Keywords : Plant Extracts
[+]

Discovery of bioactive natural products for the treatment of acute respiratory infections.Jun 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Planta Med. 2018 Jul ;84(9-10):684-695. Epub 2018 Mar 19. PMID: 29554706
Article Published Date : Jun 30, 2018
Study Type : Review
Additional Links
Substances : Anise, Bael , Black Currant, Black Pepper, Blackberry, Carrot, Chrysanthemum Indicum, Cinnamon, Elderberry, Fennel, Frankincense, Garlic, Honeysuckle, Lemon Balm, Lotus , Marigold, Medicinal Mushrooms, Mugwort, Neem, Oregano, Reishi Mushroom, Rose , Rosemary, White Mulberry , Wormwood
Diseases : Coxsackievirus Infections, Influenza, Respiratory Infections, Rhinovirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Flavonoid glycosides and alkaloids from the embryos of Nelumbo nucifera seeds and their antioxidant activity.Jan 21, 2018

Pubmed Data : Fitoterapia. 2018 Jan 22. Epub 2018 Jan 22. PMID: 29371159
Article Published Date : Jan 21, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Antioxidants, Lotus, oxidative stress
[+]

Generally used nutritional extracts of these plants have in vitro antiviral activity against rotavirus.Jul 25, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Virol J. 2012 Jul 26 ;9:137. Epub 2012 Jul 26. PMID: 22834653
Article Published Date : Jul 25, 2012
Study Type : In Vitro Study
Additional Links
Substances : Licorice, Lotus , Nettle, Olive, Rooibos
Diseases : Rotavirus Infections
Pharmacological Actions : Antiviral Agents
Additional Keywords : Antiviral Agents, Licorice, Lotus, Natural Substance Synergy, nettle, Olive, Plant Extracts, Rooibos, Rotavirus Infections
[+]

Hyperoside and rutin from lotus roots may be the promising candidates for treatment of colon cancer.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2016 Apr ;11(4):2463-2470. Epub 2016 Feb 18. PMID: 27073499
Article Published Date : Mar 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus , Rutin
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation
[+]

Isoliensinine could efficiently induce apoptosis in triple-negative breast cancer cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2015 ;5:12579. Epub 2015 Jul 29. PMID: 26219228
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic
[+]

Korean white lotus has antioxidant and antiproliferative activity against human pulmonary cancer and human gastric cancer cell lines. Oct 01, 2009

Pubmed Data : J Med Food. 2009 Oct;12(5):1057-64. PMID: 19857070
Article Published Date : Oct 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Gastric Cancer, Lung Cancer
Pharmacological Actions : Antioxidants, Antiproliferative
[+]

Lotus contains anti-HIV compounds.Jan 17, 2005

Pubmed Data : Bioorg Med Chem. 2005 Jan 17;13(2):443-8. PMID: 15598565
Article Published Date : Jan 17, 2005
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : HIV Infections
Pharmacological Actions : Anti-HIV Agents
[+]

Lotus extract inhibits Herpes simplex virus type 1 propagation. Sep 01, 2004

Pubmed Data : Gynecol Oncol. 2004 Sep;94(3):760-8. PMID: 16132118
Article Published Date : Sep 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : HSV-1
Pharmacological Actions : Antiviral Agents
Additional Keywords : Plant Extracts
[+]

Lotus has hepatoprotective and free radical scavenging effects. Mar 01, 2003

Pubmed Data : Phytomedicine. 2003 Mar;10(2-3):165-9. PMID: 12725571
Article Published Date : Mar 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Chemically-Induced Liver Damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
[+]

Lotus is a potential herbal candidate for the therapy of cardiovascular diseases associated with endothelial dysfunction and atherosclerosis.Jan 31, 2019

Pubmed Data : J Nanosci Nanotechnol. 2019 Feb 1 ;19(2):1176-1179. PMID: 30360228
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Atherosclerosis, Cardiovascular Diseases, Endothelial Dysfunction
Pharmacological Actions : Cardioprotective, Vasodilator Agents
[+]

Lotus leaf extract might be useful for treatment in therapy-resistance triple negative breast cancer.Jul 20, 2016

Pubmed Data : J Ethnopharmacol. 2016 Jul 21 ;188:111-22. Epub 2016 May 10. PMID: 27178635
Article Published Date : Jul 20, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Plant Extracts
[+]

Lotus leaf extracts could be potential therapeutic agents for prevention of photoaging-related disorders.Jul 31, 2016

Pubmed Data : J Photochem Photobiol B. 2016 Aug ;161:211-6. Epub 2016 Apr 12. PMID: 27262853
Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Ultraviolet Radiation Induced Damage
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Photoprotective
Additional Keywords : Plant Extracts
[+]

Lotus leaf flavonoids had potential to be as an ingredient in functional food for the prevention of type-2 diabetes.Sep 05, 2018

Pubmed Data : Int J Biol Macromol. 2018 Sep 6. Epub 2018 Sep 6. PMID: 30195612
Article Published Date : Sep 05, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Diabetes Mellitus: Type 2: Prevention
Pharmacological Actions : Enzyme Inhibitors: Pancreatic Amylase
[+]

Lotus rhizome and seed extract may stimulate immunity. Mar 24, 2010

Pubmed Data : J Ethnopharmacol. 2010 Mar 24;128(2):490-4. Epub 2010 Jan 14. PMID: 20079418
Article Published Date : Mar 24, 2010
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Immune Disorders: Low Immune Function
Pharmacological Actions : Immunomodulatory
[+]

Lotus root might potentially improve neural function through the stimulation of BDNF production in glial cells.May 08, 2017

Pubmed Data : J Diet Suppl. 2017 May 9:1-13. Epub 2017 May 9. PMID: 28485986
Article Published Date : May 08, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Pharmacological Actions : Brain-derived neurotrophic factor modulator, Heme oxygenase-1 up-regulation
Additional Keywords : Brain-derived neurotrophic factor modulator, Heme oxygenase-1 up-regulation, Lotus, Plant Extracts
[+]

Lotus seed epicarp could be exploited as a potential source of natural antioxidants and α-amylase inhibitors.Jul 23, 2018

Pubmed Data : Appl Biochem Biotechnol. 2018 Jul 24. Epub 2018 Jul 24. PMID: 30039473
Article Published Date : Jul 23, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Pharmacological Actions : Alpha-amylase inhibitor, Antioxidants
[+]

Lotus seed protein isolate exerts anti-inflammatory and antioxidant effects in LPS-stimulated RAW264.7 macrophages.May 17, 2019

Pubmed Data : Int J Biol Macromol. 2019 May 18 ;134:791-797. Epub 2019 May 18. PMID: 31112732
Article Published Date : May 17, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Lotus seedpod extracts reduced lipid accumulation and lipotoxicity in hepatocytes.Nov 27, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Nov 28 ;11(12). Epub 2019 Nov 28. PMID: 31795130
Article Published Date : Nov 27, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Apoptotic, Hepatoprotective, Hypolipidemic
[+]

Lotus seedpod proanthocyanidins protect against neurotoxicity after methyl-mercuric chloride injury.Nov 14, 2019

Pubmed Data : Ecotoxicol Environ Saf. 2019 Nov 15 ;183:109560. Epub 2019 Aug 14. PMID: 31421536
Article Published Date : Nov 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
Additional Keywords : Proanthocyanidins
Problem Substances : Mercury
[+]

Lotus stamen has antioxidant properties.Apr 01, 2003

Pubmed Data : Arch Pharm Res. 2003 Apr;26(4):279-85. PMID: 12735685
Article Published Date : Apr 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Kaempferol, Lotus
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Lotusine pre-treatment has exhibited potential cardioprotective activity against doxorubicin-induced oxidative stress.Apr 30, 2020

Pubmed Data : In Vitro Cell Dev Biol Anim. 2020 May ;56(5):367-377. Epub 2020 May 29. PMID: 32468412
Article Published Date : Apr 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Anti-Apoptotic, Cardioprotective, Chemoprotective Agents
[+]

N. nucifera leaves can be used as potential preventative therapies against angiogenesis-related diseases.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(2):e0118552. Epub 2015 Feb 25. PMID: 25714482
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Pharmacological Actions : Anti-Angiogenic, Antioxidants, Antiproliferative
Additional Keywords : Plant Extracts
[+]

N. nucifera possesses potent cholinesterases and BACE1-inhibitory activities.May 31, 2015

Pubmed Data : Arch Pharm Res. 2015 Jun ;38(6):1178-87. Epub 2014 Oct 11. PMID: 25300425
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Cholinesterase Inhibitors
Additional Keywords : Plant Extracts
[+]

Neferine ameliorates cardiomyoblast apoptosis induced by doxorubicin.Sep 24, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Sep 25 ;7(1):12283. Epub 2017 Sep 25. PMID: 28947826
Article Published Date : Sep 24, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Chemoprotective Agents
Additional Keywords : Anti-Inflammatory Agents, Cardioprotective, Chemoprotective Agents, Lotus
[+]

Neferine and isoliensinine enhance intracellular uptake of cisplatin and induce ROS-mediated apoptosis in colorectal cancer cells.Jun 26, 2019

Pubmed Data : Food Chem Toxicol. 2019 Jun 27 ;132:110652. Epub 2019 Jun 27. PMID: 31255669
Article Published Date : Jun 26, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Colorectal Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Neferine attenuates the protein level and toxicity of mutant huntingtin in PC-12 cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2015 ;20(3):3496-514. Epub 2015 Feb 18. PMID: 25699594
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Huntington Disease, Neurodegenerative Diseases
Pharmacological Actions : Anti-Apoptotic, Autophagy Up-regulation, Neuroprotective Agents
[+]

Neferine augments the therapeutic efficacy of cisplatin in human lung adenocarcinoma cells.Apr 30, 2017

Pubmed Data : Food Chem Toxicol. 2017 May ;103:28-40. Epub 2017 Feb 20. PMID: 28223119
Article Published Date : Apr 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Lung Cancer
Pharmacological Actions : Autophagy Up-regulation, Chemotherapeutic
Additional Keywords : Autophagy Up-regulation, Chemotherapeutic, Chemotherapeutic Synergy: Cisplatin, Lotus, lung cancer
[+]

Neferine can prevent UV-B induced oxidative damage and may thus be a potential agent for prevention and treatment of skin damage and photoaging.Mar 12, 2018

Pubmed Data : J Dermatolog Treat. 2018 Mar 13:1-27. Epub 2018 Mar 13. PMID: 29532689
Article Published Date : Mar 12, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Ultraviolet Radiation Induced Damage
Pharmacological Actions : Antioxidants, Photoprotective
[+]

Neferine could be a potential therapeutic application for against osteolytic bone conditions such as osteoporosis.May 23, 2019

Pubmed Data : J Cell Physiol. 2019 May 24. Epub 2019 May 24. PMID: 31127627
Article Published Date : May 23, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Osteoprotective
[+]

Neferine could be beneficial in the early treatment of atherosclerosis to prevent stroke and heart disease.Dec 31, 2017

Pubmed Data : Pharmazie. 2018 09 1 ;73(9):541-544. PMID: 30223939
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Atherosclerosis, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Neferine enhances oxaliplatin sensitivity through an inhibition of EMT in liver cancer cells.Jan 29, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Jan 30 ;7:41616. Epub 2017 Jan 30. PMID: 28134289
Article Published Date : Jan 29, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Liver Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemosensitizer, Chemotherapeutic Synergy: Oxaliplatin, liver cancer, Lotus
[+]

Neferine enhances the antitumor effect of mitomycin-c in hela cells.Mar 21, 2017

Pubmed Data : J Cell Biochem. 2017 Mar 22. Epub 2017 Mar 22. PMID: 28328092
Article Published Date : Mar 21, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Apoptotic, Cervical Cancer, Chemotherapeutic Synergy: Mitomycin C, Lotus
[+]

Neferine from Nelumbo nucifera induces autophagy in A549 cells.Dec 14, 2013

Pubmed Data : Food Chem. 2013 Dec 15 ;141(4):3598-605. Epub 2013 Jun 7. PMID: 23993526
Article Published Date : Dec 14, 2013
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
Additional Keywords : Plant Extracts
[+]

Neferine has strong antioxidative and photoprotective properties.Dec 20, 2018

Pubmed Data : Biosci Rep. 2018 Dec 21 ;38(6). Epub 2018 Dec 14. PMID: 30355644
Article Published Date : Dec 20, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Aging Skin, Oxidative Stress, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Antioxidants, Matrix metalloproteinase-1 (MMP-1) inhibitor, Photoprotective
[+]

Neferine hinders choriocarcinoma cell proliferation, migration and invasion through repression of long noncoding RNA-CHRF.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Artif Cells Nanomed Biotechnol. 2019 Dec ;47(1):4089-4096. PMID: 31630562
Article Published Date : Nov 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Choriocarcinoma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma.Aug 31, 2020

Pubmed Data : Oncol Rep. 2020 Sep ;44(3):1116-1126. Epub 2020 Jul 7. PMID: 32705225
Article Published Date : Aug 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Esophageal Cancer
Pharmacological Actions : Apoptotic
[+]

Neferine induces autophagy-dependent cell death in apoptosis-resistant cancers.Dec 26, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 Dec 27 ;9(1):20034. Epub 2019 Dec 27. PMID: 31882989
Article Published Date : Dec 26, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cancers: All, Cancers: Drug Resistant
Pharmacological Actions : Autophagy Up-regulation, Chemotherapeutic
[+]

Neferine inhibits growth and migration of gastrointestinal stromal tumor cell line GIST-T1.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:1951-1959. Epub 2018 Nov 26. PMID: 30551450
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Gastrointestinal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, MicroRNA modulator
[+]

Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis.Jun 05, 2019

Pubmed Data : Inflamm Res. 2019 Jun 6. Epub 2019 Jun 6. PMID: 31172209
Article Published Date : Jun 05, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Chronic Kidney Disease (CKD), Endothelial Dysfunction
Pharmacological Actions : Antioxidants
[+]

Neferine inhibits MDA-MB-231 cells growth and metastasis by regulating miR-374a/FGFR-2.Jun 14, 2019

Pubmed Data : Chem Biol Interact. 2019 Jun 15 ;309:108716. Epub 2019 Jun 15. PMID: 31207222
Article Published Date : Jun 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative , MicroRNA modulator
[+]

Neferine inhibits proliferation and migration of human prostate cancer stem cells.May 10, 2020

Pubmed Data : J Food Biochem. 2020 May 11:e13253. Epub 2020 May 11. PMID: 32394497
Article Published Date : May 10, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Cancer Stem Cells
[+]

Neferine inhibits proliferation, migration and invasion of U251 glioma cellsDec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:1032-1040. Epub 2018 Nov 6. PMID: 30551353
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Glioma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

Neferine is a potential treatment for type 2 diabetes.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:999. Epub 2019 Sep 4. PMID: 31551792
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents
[+]

Neferine is a promising pharmacotherapy for osteoarthritis.Jun 01, 2020

Pubmed Data : Inflammation. 2020 Jun 2. Epub 2020 Jun 2. PMID: 32488683
Article Published Date : Jun 01, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Osteoprotective
[+]

Neferine may be a potential candidate molecule in the treatment of proliferative vitreoretinopathy.May 31, 2020

Pubmed Data : Cutan Ocul Toxicol. 2020 Jun ;39(2):97-105. Epub 2020 Mar 9. PMID: 32064963
Article Published Date : May 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Retinal Detachment
Pharmacological Actions : Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, P21 Activation
[+]

Neferine may be explored as a promising antitumoral agent in ovarian cancer.Jan 06, 2016

Pubmed Data : Tumour Biol. 2016 Jan 7. Epub 2016 Jan 7. PMID: 26738868
Article Published Date : Jan 06, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Autophagy Up-regulation
[+]

Neferine may be used as prophylactic agent against the hypoxic challenge.Jul 07, 2016

Pubmed Data : Biofactors. 2016 Jul 8 ;42(4):407-17. Epub 2016 Apr 4. PMID: 27041079
Article Published Date : Jul 07, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Hypoxia, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Cytoprotective, Prophylactic Agents
[+]

Neferine may serve as a therapeutic candidate for obesity treatment.Jun 21, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Jun 22 ;12(6). Epub 2020 Jun 22. PMID: 32580414
Article Published Date : Jun 21, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents
[+]

Neferine might be a potential candidate against human neuroblastoma cells.Nov 27, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Nov 28 ;23(12). Epub 2018 Nov 28. PMID: 30486505
Article Published Date : Nov 27, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Neuroblastoma
Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation, Cell cycle arrest
[+]

Neferine might be a promising natural compound to potentiate imatinib in CML patients.Mar 31, 2019

Pubmed Data : J Food Sci. 2019 Apr ;84(4):904-910. Epub 2019 Mar 13. PMID: 30866043
Article Published Date : Mar 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cancers: Drug Resistant, Chronic Myeloid Leukemia
Pharmacological Actions : Antineoplastic Agents, Apoptotic
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Neferine prevented hyperglycemia-induced endothelial cell apoptosis.Nov 30, 2014

Pubmed Data : Endocrine. 2014 Dec ;47(3):764-71. Epub 2014 Mar 4. PMID: 24590293
Article Published Date : Nov 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Hyperglycemia, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, NF-kappaB Inhibitor
[+]

Neferine prevents ultraviolet radiation-induced skin photoaging. Apr 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2020 May ;19(5):3189-3196. Epub 2020 Mar 9. PMID: 32266014
Article Published Date : Apr 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Photooxidative Stress, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Antioxidants, Photoprotective
[+]

Neferine reduces cisplatin-induced nephrotoxicity by enhancing autophagy.Mar 10, 2017

Pubmed Data : Biochem Biophys Res Commun. 2017 Mar 11 ;484(3):694-701. Epub 2017 Feb 1. PMID: 28161641
Article Published Date : Mar 10, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Autophagy Up-regulation, Chemoprotective Agents
Additional Keywords : Autophagy Up-regulation, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Lotus
[+]

Neferine reduces the cisplatin dose requirement in cancer chemotherapy.Feb 17, 2017

Pubmed Data : J Cell Biochem. 2017 Feb 18. Epub 2017 Feb 18. PMID: 28214344
Article Published Date : Feb 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Apoptotic, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin, Lotus, lung cancer, Vascular Endothelial Growth Factor Inhibitors
[+]

Neferine revealed higher toxicity toward paclitaxel and doxorubicin-resistant breast, lung or colon cancer cells.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2017 ;8:238. Epub 2017 May 5. PMID: 28529482
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Breast Cancer, Cancers: Multi-Drug Resistant, Colon Cancer, Lung Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Breast Cancer, Cancers: Multi-Drug Resistant, Chemosensitizer, Chemotherapeutic, COLON CANCER, Lotus, lung cancer
[+]

Neferine sensitized Taxol-resistant nasopharygeal carcinoma to taxol.Oct 21, 2020

Pubmed Data : Biochem Biophys Res Commun. 2020 Oct 22 ;531(4):573-580. Epub 2020 Aug 15. PMID: 32811645
Article Published Date : Oct 21, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Chemosensitizer, MicroRNA modulator
[+]

Neferine suppresses diethylnitrosamine-induced lung carcinogenesis in Wistar rats.Nov 09, 2018

Pubmed Data : Food Chem Toxicol. 2018 Nov 10 ;123:385-398. Epub 2018 Nov 10. PMID: 30423403
Article Published Date : Nov 09, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Lung Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

Neferine targets HeLa and SiHa cervical cancer cells.May 03, 2020

Pubmed Data : Phytother Res. 2020 May 4. Epub 2020 May 4. PMID: 32364634
Article Published Date : May 03, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
[+]

Neferine treatment enhances the TRAIL-induced apoptosis of human prostate cancer cells.Apr 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2020 May ;56(5):1152-1161. Epub 2020 Mar 13. PMID: 32319589
Article Published Date : Apr 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic
[+]

Neferine, a compound found within the lotus, reverses multidrug resistance in human gastric cancer cells. Oct 15, 2004

Pubmed Data : World J Gastroenterol. 2004 Oct 15;10(20):3062-4. PMID: 15378795
Article Published Date : Oct 15, 2004
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cancers: Multi-Drug Resistant, Gastric Cancer
Additional Keywords : Disease Reversal
[+]

Neferine-induced apoptosis is dependent on the suppression of Bcl-2 expression via downregulation of p65 in renal cancer cells.Jun 11, 2019

Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2019 Jun 12. Epub 2019 Jun 12. PMID: 31187116
Article Published Date : Jun 11, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Kidney Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Nelumbo leaf extracts can ameliorate disease conditions involving chronic inflammation.Jul 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Res Pract. 2017 Aug ;11(4):265-274. Epub 2017 Jul 21. PMID: 28765772
Article Published Date : Jul 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Inflammatory Agents, Inflammation, Lotus
[+]

Nelumbo nucifera extract suppresses angiotensin II-induced cardiomyocyte hypertrophy.Apr 25, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Apr 26 ;24(9). Epub 2019 Apr 26. PMID: 31027372
Article Published Date : Apr 25, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Cardioprotective
[+]

Nelumbo nucifera leaves prevent NMU-induced mammary tumor.Dec 31, 2018

Pubmed Data : Am J Chin Med. 2019 ;47(8):1885-1899. PMID: 31838869
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Breast Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Nelumbo nucifera leaves protect against hydrogen peroxide-induced hepatic damage.May 31, 2015

Pubmed Data : Food Funct. 2015 Jun ;6(6):1911-8. PMID: 25962859
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Chemically-Induced Liver Damage, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

Nelumbo nucifera seed may be of use in the treatment and prevention of neurodegenerative disorders.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2014 ;2014:869831. Epub 2014 Dec 24. PMID: 25610484
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Cognitive Decline/Dysfunction, Memory Disorders: Drug-Induced
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Neuroprotective effects of lotus seedpod procyanidins on extremely low frequency electromagnetic field-induced neurotoxicity.Jul 31, 2016

Pubmed Data : Biomed Pharmacother. 2016 Aug ;82:628-39. Epub 2016 Jun 13. PMID: 27470406
Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : DNA damage, Electromagnetic Radiation Mitigation
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Bcl-2 protein down-regulation, Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation
Additional Keywords : Proanthocyanidins
Anti Therapeutic Actions : Electromagnetic Field Harms
[+]

Nuciferine inhibits proinflammatory cytokines via the PPARs in LPS-induced RAW264.7 cells.Oct 21, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Oct 22 ;23(10). Epub 2018 Oct 22. PMID: 30360404
Article Published Date : Oct 21, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Nuciferine inhibits skin cutaneous melanoma cell growth by suppressing TLR4/NF-κB signalling.Aug 09, 2020

Pubmed Data : Anticancer Agents Med Chem. 2020 Aug 10. Epub 2020 Aug 10. PMID: 32781974
Article Published Date : Aug 09, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Melanoma
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Nuciferine inhibits the progression of glioblastoma.Mar 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2019 Mar 29 ;38(1):139. Epub 2019 Mar 29. PMID: 30922391
Article Published Date : Mar 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Nuciferine prevents bone loss by disrupting multinucleated osteoclast formation and promoting type H vessel formation.Feb 29, 2020

Pubmed Data : FASEB J. 2020 Mar ;34(3):4798-4811. Epub 2020 Feb 10. PMID: 32039519
Article Published Date : Feb 29, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Osteoarthritis
Pharmacological Actions : Osteoprotective
[+]

Phenolic rich ethyl acetate fractions from lotus leaves have great potential to be used against oxidative stress-induced health conditions.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Prev Nutr Food Sci. 2015 Mar ;20(1):22-8. Epub 2015 Mar 31. PMID: 25866746
Article Published Date : Feb 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Cytoprotective
Additional Keywords : Plant Extracts
[+]

Plumula nelumbinis: A review of traditional uses, phytochemistry, pharmacology, pharmacokinetics and safety.Sep 30, 2020

Pubmed Data : J Ethnopharmacol. 2020 Oct 1:113429. Epub 2020 Oct 1. PMID: 33011369
Article Published Date : Sep 30, 2020
Study Type : Review
Additional Links
Substances : Lotus
Diseases : Cardiovascular Diseases, Hypertension, Kidney Damage, Liver Damage
Pharmacological Actions : Antihypertensive Agents, Antioxidants, Cardioprotective, Hepatoprotective, Renoprotective
[+]

Polysaccharides isolated from lotus leaves exert anti-osteoporotic effects.Jun 08, 2020

Pubmed Data : Int J Biol Macromol. 2020 Jun 9 ;161:449-456. Epub 2020 Jun 9. PMID: 32531355
Article Published Date : Jun 08, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
Additional Keywords : Polysaccharides
[+]

Procyanidins from lotus seedpod induced autophagy and autophagic cell death in HepG2 cells.Mar 31, 2016

Pubmed Data : Biomed Pharmacother. 2016 Apr ;79:135-52. Epub 2016 Feb 22. PMID: 27044822
Article Published Date : Mar 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Liver Cancer
Pharmacological Actions : Autophagy Up-regulation
Additional Keywords : Dose Response, Procyanidins
[+]

Protective effect of Nelumbo nucifera (Gaertn.) against H2O2-induced oxidative stress on H9c2 cardiomyocytes.Dec 10, 2019

Pubmed Data : Mol Biol Rep. 2019 Dec 11. Epub 2019 Dec 11. PMID: 31823124
Article Published Date : Dec 10, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Protective effect of Nelumbo nucifera extracts on beta amyloid protein induced apoptosis in PC12 cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Food Drug Anal. 2018 Jan ;26(1):172-181. Epub 2017 Mar 17. PMID: 29389553
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Quercetin-3-O-β-d-glucuronide from lotus leaves could significantly inhibit LPS-induced NO release in vitro in a dose-dependent manner.Dec 31, 2016

Pubmed Data : J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 1 ;1040:186-191. Epub 2016 Dec 12. PMID: 27987489
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Anti-Inflammatory Agents, Dose Response, Inflammation, Lipopolysaccharide-Induced Toxicity, Lotus
[+]

The cytoprotective and anti-cancer potential of bisbenzylisoquinoline alkaloids from Nelumbo nucifera.Nov 15, 2019

Pubmed Data : Curr Top Med Chem. 2019 Nov 16. Epub 2019 Nov 16. PMID: 31738137
Article Published Date : Nov 15, 2019
Study Type : Review
Additional Links
Substances : Lotus
Diseases : Chemotherapy and Radiation Toxicity, Diabetes Mellitus: Type 2, Stroke: Ischemic
Pharmacological Actions : Chemoprotective Agents, Chemosensitizer, Neuroprotective Agents
[+]

The Effect of sacred lotus and its mixtures on phenolic profiles, antioxidant activities, and inhibitions of the key enzymes relevant to Alzheimer's disease.Aug 13, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Aug 14 ;25(16). Epub 2020 Aug 14. PMID: 32824050
Article Published Date : Aug 13, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

The findings of this study provide evidences that the inedible lotus seedpod could be a source for natural antioxidants and anticancer agents.Aug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Sci Nutr. 2019 Sep ;7(9):3062-3070. Epub 2019 Aug 9. PMID: 31572599
Article Published Date : Aug 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus , Polyphenols
Diseases : Liver Cancer, Prostate Cancer
Pharmacological Actions : Antioxidants, Antiproliferative
[+]

The flavonoid C-glycosides of lotus seed embryos had higher antioxidant properties than the flavonoid O-glycosides presented in lotus leaves.Jun 19, 2017

Pubmed Data : J Food Sci. 2017 Jun 20. Epub 2017 Jun 20. PMID: 28631810
Article Published Date : Jun 19, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

The results of this study suggest the role of neferine in preventing hypoxia induced autophagy in muscle cells.Sep 30, 2016

Pubmed Data : Biomed Pharmacother. 2016 Oct ;83:1407-1413. Epub 2016 Aug 29. PMID: 27583981
Article Published Date : Sep 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Hypoxia, Muscle Damage
Pharmacological Actions : Antioxidants, Autophagy Inhibitors, Cytoprotective, NF-E2-Related Factor-2 (Nrf2) Modulator
[+]

These data suggested that liensinine might represent a novel and effective agent against gastric cancer.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer. 2019 ;10(25):6431-6438. Epub 2019 Oct 19. PMID: 31772676
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

These findings suggest that polysaccharides extracted from lotus leaf exert immunostimulatory activity.Apr 30, 2019

Pubmed Data : Int J Biol Macromol. 2019 May 1 ;128:546-555. Epub 2019 Jan 25. PMID: 30685309
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Pharmacological Actions : Immunostimulatory
Additional Keywords : Polysaccharides
[+]

These findings suggested that Neferine could be a new treatment or adjuvant against retinoblastoma.May 27, 2020

Pubmed Data : Exp Biol Med (Maywood). 2020 May 28:1535370220928933. Epub 2020 May 28. PMID: 32460625
Article Published Date : May 27, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Retinoblastoma
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative
[+]

These observations reveal that the therapeutic potential of neferine in treating HCC Hep3B cells, containing copies of hepatitis B virus genomes.Aug 14, 2013

Pubmed Data : Phytomedicine. 2013 Aug 15 ;20(11):1013-22. Epub 2013 Jun 6. PMID: 23746959
Article Published Date : Aug 14, 2013
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Liver Cancer
Pharmacological Actions : Anti-Angiogenic, Apoptotic, Cell cycle arrest
Additional Keywords : Phytotherapy, Plant Extracts
[+]

These results suggested the potential of neferine as a therapeutic agent for acute respiratory distress syndrome.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Physiol. 2018 ;9:102. Epub 2018 Feb 22. PMID: 29520236
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Acute Respiratory Distress Syndrome, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents
[+]

These results validate the traditional use of Nelumbo Nucifera leaves for the management of diabetes.Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Tradit Chin Med. 2016 Feb ;36(1):71-7. PMID: 26946622
Article Published Date : Jan 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic, Insulin-releasing, Interleukin-1 beta downregulation
Additional Keywords : Plant Extracts
[+]

This study suggests the use of neferine for amelioration of doxorubicin -mediated cardiotoxicity.Jul 20, 2017

Pubmed Data : J Cell Biochem. 2017 Jul 21. Epub 2017 Jul 21. PMID: 28731223
Article Published Date : Jul 20, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Cardioprotective, Chemoprotective Agents
Additional Keywords : Cardioprotective, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Doxorubicin, Lotus

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