Lotus

Name	AC	CK
Oxidative Stress	27	40
Obesity	19	33
Inflammation	19	26
High Fat Diet	8	16
Sleep Disorders	4	16
Alzheimer's Disease	9	14
Lung Cancer	11	13
Aging Skin	3	12
Lipopolysaccharide-Induced Toxicity	9	11
Fatigue	1	10
Liver Cancer	7	10
Memory Disorders	5	10
Overweight	1	10
Diabetes Mellitus: Type 2	5	8
Chemotherapy-Induced Toxicity: Doxorubicin	5	7
Cognitive Decline/Dysfunction	4	7
Hyperglycemia	6	7
Hypoxia	3	7
Lipid Peroxidation	4	7
Ulcerative Colitis	4	7
Aging	4	6
Aging: Brain	3	6
Chemically-Induced Liver Damage	4	6
Chemotherapy-Induced Toxicity: Cisplatin	4	6
Endothelial Dysfunction	4	6
Hepatic Steatosis	3	6
Nonalcoholic fatty liver disease (NAFLD)	3	6
Ultraviolet Radiation Induced Damage	5	6
Atherosclerosis	5	5
Cancers: Drug Resistant	4	5
Colon Cancer	5	5
Gastric Cancer	4	5
Hypertension	3	5
Insulin Resistance	3	5
Kidney Damage	3	5
Liver Cirrhosis	2	5
Myocardial Infarction	3	5
Prostate Cancer	5	5
Stroke: Ischemic	3	5
Asthma	2	4
Breast Cancer	4	4
Cancers: All	4	4
Carcinoma: Non-Small-Cell Lung	3	4
Cervical Cancer	4	4
Chemotherapy-Induced Kidney Damage	2	4
Depression	2	4
Diabetes: Cataract	2	4
Liver Fibrosis	2	4
Prostatic Hyperplasia: Benign	3	4
Seizures	2	4
Atopic Dermatitis	2	3
Breast Cancer: Triple Negative	3	3
Diabetes Mellitus: Type 1	2	3
Diabetic Nephropathy	2	3
Fever	2	3
HIV Infections	3	3
Hypoglycemia	1	3
Muscle Atrophy	2	3
Myocardial Fibrosis	2	3
Neurodegenerative Diseases	3	3
Osteoarthritis	3	3
Osteoporosis	2	3
Ovarian Cancer	2	3
Sepsis	2	3
Squamous cell carcinoma	2	3
Subarachnoid hemorrhage	1	3
Alcohol Toxicity	1	2
Aluminum Toxicity	1	2
Anxiety	1	2
Anxiety Disorders	1	2
Arteriosclerosis	1	2
Brain Damage	1	2
Cancers: Multi-Drug Resistant	2	2
Cardiovascular Diseases	2	2
Cerebral Ischemia	1	2
Diabetes: Cognitive Dysfunction	1	2
Diabetes: Glycation/A1C	1	2
Diabetic Complications	1	2
Diabetic Ulcer	1	2
Encephalopathy: Hypoxic	1	2
Epilepsy	1	2
Fatty Liver	1	2
Gestational Diabetes	1	2
Hyperlipidemia	2	2
Hyperuricemia	1	2
Kidney Cancer	2	2
Learning disorders	1	2
Liver Steatosis	1	2
Lupus Erythematosus: Systemic	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Myocardial Ischemia	1	2
Nasopharyngeal Cancer	2	2
Nephropathy	1	2
Neurodegeneration: Dentate Gyrus	1	2
Neuropathic Pain	1	2
Nicotine/Tobacco Toxicity	1	2
Parkinson's Disease	1	2
Pesticide Toxicity	1	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Triglycerides: Elevated	1	2
Wound Healing	1	2
Acetaminophen (Tylenol) Toxicity	1	1
Acute Respiratory Distress Syndrome	1	1
Allergies	1	1
Breast Cancer: Chemically-Induced	1	1
Cardiac Hypertrophy	1	1
Chemotherapy and Radiation Toxicity	1	1
Choriocarcinoma	1	1
Chronic Kidney Disease (CKD)	1	1
Chronic Myeloid Leukemia	1	1
Colitis	1	1
Colorectal Cancer	1	1
Coronavirus Infection	1	1
Coxsackievirus Infections	1	1
DNA damage	1	1
Diabetes Mellitus: Type 2: Prevention	1	1
Dyslipidemias	1	1
Electromagnetic Radiation Mitigation	1	1
Endometriosis	1	1
Esophageal Cancer	1	1
Gastrointestinal Cancer	1	1
Glioblastoma	1	1
Glioma	1	1
Graves Disease	1	1
HSV-1	1	1
Head and Neck Cancer	1	1
Huntington Disease	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Immune Disorders: Low Immune Function	1	1
Influenza	1	1
Liver Damage	1	1
Liver Damage: Drug-Induced	1	1
Melanoma	1	1
Memory Disorders: Drug-Induced	1	1
Metabolic Diseases	1	1
Muscle Damage	1	1
Neuroblastoma	1	1
Oral Cancer	1	1
Osteosarcoma	1	1
Peripheral Neuropathies	1	1
Photooxidative Stress	1	1
Respiratory Infections	1	1
Restenosis	1	1
Retinal Detachment	1	1
Retinoblastoma	1	1
Rhinovirus Infection	1	1
Rotavirus Infections	1	1

Name	AC	CK
Antioxidants	61	101
Anti-Inflammatory Agents	50	81
Neuroprotective Agents	30	51
Tumor Necrosis Factor (TNF) Alpha Inhibitor	23	42
Apoptotic	32	34
Antiproliferative	29	32
Hepatoprotective	18	31
NF-kappaB Inhibitor	20	30
Hypolipidemic	13	27
Interleukin-6 Downregulation	13	24
Anti-Apoptotic	17	23
Cardioprotective	15	21
Interleukin-1 beta downregulation	13	21
Hypoglycemic Agents	11	17
Renoprotective	8	15
Chemoprotective Agents	11	14
Gastrointestinal Agents	8	14
Nrf2 activation	9	14
Autophagy Up-regulation	12	13
Chemosensitizer	12	13
Cyclooxygenase 2 Inhibitors	7	9
Malondialdehyde Down-regulation	5	9
Superoxide Dismutase Up-regulation	6	9
Anti-Fibrotic	5	8
Anti-metastatic	8	8
Cytoprotective	4	8
Immunomodulatory	5	8
Interleukin-8 downregulation	3	7
Antihypertensive Agents	4	6
Antiviral Agents	6	6
Chemopreventive	5	6
Photoprotective	5	6
Chemotherapeutic	4	5
Heme oxygenase-1 up-regulation	5	5
Vasodilator Agents	3	5
Aldose reductase inhibitor	2	4
Angiogenesis Inhibitors	3	4
Anticarcinogenic Agents	3	4
Antidepressive Agents	2	4
Antineoplastic Agents	3	4
Bcl-2 protein down-regulation	4	4
Cell cycle arrest	4	4
GABA Modulators	2	4
MicroRNA modulator	4	4
Osteoprotective	4	4
Anti-pyretic	2	3
Hypnotics and Sedatives	2	3
Matrix metalloproteinase-2 (MMP-2) inhibitor	3	3
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	3
Neuritogenic	2	3
Transforming growth factor beta (TGF-β) inhibitor	2	3
Alpha-glucosidase inhibitor	2	2
Analgesics	1	2
Anti-Allergic Agents	2	2
Anti-Angiogenic	2	2
Anti-Anxiety Agents	1	2
Anti-Ulcer Agents	1	2
Anticholesteremic Agents	1	2
Anticonvulsants	1	2
Antimicrobial	2	2
Anxiolytic	1	2
Bax/Bcl2 Ratio: Decrease	1	2
Cytotoxic	1	2
Histamine Antagonists	1	2
Insulin-releasing	2	2
Interleukin-10 upregulation	1	2
Neurogenesis	1	2
Nitric Oxide Inhibitor	1	2
Osteogenic	1	2
Sedative effects	1	2
Vascular Cell Adhesion Molecule-1 Inhibitor	1	2
Vascular Endothelial Growth Factor Inhibitors	2	2
Wnt/β-catenin pathway down-regulation	1	2
Acetylcholinesterase Inhibitor	1	1
Alpha-amylase inhibitor	1	1
Anti-Adipogenic	1	1
Anti-HIV Agents	1	1
Anti-Retroviral Agents	1	1
Anti-atherogenic	1	1
Autophagy Inhibitors	1	1
Bcl-xL down-regulation	1	1
Brain-derived neurotrophic factor modulator	1	1
Caspase-3 Activation	1	1
Caspase-8 activation	1	1
Caspase-9 Activation	1	1
Catalase Up-Regulation	1	1
Cholinesterase Inhibitors	1	1
Enzyme Inhibitors: Pancreatic Amylase	1	1
Immunostimulatory	1	1
Interleukin-18 down-regulation	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
NF-E2-Related Factor-2 (Nrf2) Modulator	1	1
P21 Activation	1	1
Postaglandin PGE2 downregulation	1	1
Prophylactic Agents	1	1
SIRT1 Activator	1	1
Transforming growth factor beta (TGF-β) upregulation	1	1

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Pubmed Data : Cardiovasc Toxicol. 2021 11 ;21(11):947-963. Epub 2021 Aug 16. PMID: 34401977

Article Published Date : Jan 10, 2021

Study Type : Animal Study, In Vitro Study

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Substances : Lotus

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress

Pharmacological Actions : Antioxidants, Cardioprotective

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Neuroprotective effect of white Nelumbo nucifera petal tea in rats poisoned with mancozeb.May 27, 2023

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Pubmed Data : Foods. 2023 May 28 ;12(11). Epub 2023 May 28. PMID: 37297420

Article Published Date : May 27, 2023

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Pubmed Data : Pharmaceuticals (Basel). 2022 Jan 10 ;15(1). Epub 2022 Jan 10. PMID: 35056140

Article Published Date : Jan 09, 2022

Study Type : Animal Study, In Vitro Study

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Substances : Lotus

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Extracts from Nelumbo nucifera leaves had significantly hepatoprotective effect for Calcium tetrachloride CCl4-induced liver injury.Dec 31, 2013

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Pubmed Data : Afr J Tradit Complement Altern Med. 2014 ;11(3):85-91. Epub 2014 Apr 3. PMID: 25371567

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Pubmed Data : J Agric Food Chem. 2010 Jun 9;58(11):7075-81. PMID: 20481471

Article Published Date : Jun 09, 2010

Study Type : Animal Study

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Substances : Flavonoids, Lotus

Diseases : Obesity

Additional Keywords : Anti-Obesity Agents, Plant Extracts

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Lotus has antipyretic properties.Jun 01, 2000

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Pubmed Data : Phytother Res. 2000 Jun;14(4):272-4. PMID: 10861971

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Pubmed Data : Biosci Biotechnol Biochem. 2008 Feb;72(2):477-84. Epub 2008 Feb 7. PMID: 16495025

Article Published Date : Feb 01, 2008

Study Type : Animal Study

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Substances : Lotus

Diseases : Obesity

Additional Keywords : Anti-Obesity Agents, Plant Extracts

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Lotus procyanidins reverse memory impairments in cognitivitely impaired aged rats.Sep 01, 2010

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Pubmed Data : J Gerontol A Biol Sci Med Sci. 2010 Sep;65(9):933-40. Epub 2010 Jun 7. PMID: 20530246

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Pubmed Data : Biomed Pharmacother. 2016 Aug ;82:640-8. Epub 2016 Jun 13. PMID: 27470407

Pubmed Data : Food Funct. 2013 Aug ;4(8):1252-62. PMID: 23764910

Article Published Date : Aug 01, 2013

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Pubmed Data : Nutrients. 2023 Feb 4 ;15(4). Epub 2023 Feb 4. PMID: 36839161

Article Published Date : Feb 03, 2023

Pubmed Data : Mol Omics. 2022 Jul 27. Epub 2022 Jul 27. PMID: 35894702

Article Published Date : Jul 26, 2022

Study Type : Animal Study

Additional Links

Substances : Lotus

Diseases : Stroke: Ischemic

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Malondialdehyde Down-regulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

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Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:4572893. Epub 2018 Oct 28. PMID: 30538801

Article Published Date : Dec 31, 2017

Study Type : Animal Study, In Vitro Study

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Substances : Lotus

Diseases : Alzheimer's Disease

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

Additional Keywords : Plant Extracts, Proanthocyanidins

[+]

Procyanidins extracted from the lotus seedpod ameliorate scopolamine-induced memory impairment in mice.Jan 13, 2010

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Pubmed Data : Phytother Res. 2010 Jan 13. Epub 2010 Jan 13. PMID: 19367674

Article Published Date : Jan 13, 2010

Study Type : Animal Study

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Substances : Lotus

Diseases : Memory Disorders

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts, Proanthocyanidins

[+]

Protection against dextran sulfate sodium-induced ulcerative colitis in mice by neferine.Dec 31, 2020

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Pubmed Data : Cell J. 2021 Jan ;22(4):523-531. Epub 2020 Apr 22. PMID: 32347046

Article Published Date : Dec 31, 2020

Study Type : Animal Study

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Substances : Lotus

Diseases : Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

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Pubmed Data : Food Funct. 2021 Nov 15 ;12(22):11174-11189. Epub 2021 Nov 15. PMID: 34636388

Article Published Date : Nov 14, 2021

Study Type : Animal Study

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Substances : Lotus

Diseases : Gestational Diabetes

Pharmacological Actions : Gastrointestinal Agents, Hypolipidemic

[+]

These results indicate that Enterococcus fermented lotus leaf supernatant can potentially be developed as an healthy, anti-obesity foodstuff.Oct 16, 2022

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Pubmed Data : Nutrients. 2022 Oct 17 ;14(20). Epub 2022 Oct 17. PMID: 36297031

Article Published Date : Oct 16, 2022

Study Type : Animal Study

Additional Links

Substances : Fermented Foods and Beverages, Lotus

Diseases : Obesity

Pharmacological Actions : Hypolipidemic

Additional Keywords : Anti-Obesity Agents

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An updated review on Nelumbo nucifera: chemical composition, nutritional value and pharmacological activities.Apr 30, 2024

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Pubmed Data : Chem Biodivers. 2024 May ;21(5):e202301493. Epub 2024 Apr 17. PMID: 38327030

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Pubmed Data : Nutrients. 2018 Dec 7 ;10(12). Epub 2018 Dec 7. PMID: 30544543

Article Published Date : Dec 06, 2018

Study Type : In Vitro Study

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Substances : Dandelion , Lotus

Diseases : Prostatic Hyperplasia: Benign

Additional Keywords : Plant Extracts

[+]

Discovery of bioactive natural products for the treatment of acute respiratory infections.Jun 30, 2018

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Pubmed Data : J Ethnopharmacol. 2010 Mar 24;128(2):490-4. Epub 2010 Jan 14. PMID: 20079418

Article Published Date : Mar 24, 2010

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Immune Disorders: Low Immune Function

Pharmacological Actions : Immunomodulatory

[+]

Lotus root might potentially improve neural function through the stimulation of BDNF production in glial cells.May 08, 2017

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Pubmed Data : J Diet Suppl. 2017 May 9:1-13. Epub 2017 May 9. PMID: 28485986

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Pubmed Data : J Food Biochem. 2020 Dec 31:e13601. Epub 2020 Dec 31. PMID: 33381866

Article Published Date : Dec 30, 2020

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Apoptotic

[+]

Lotus seedpod extracts reduced lipid accumulation and lipotoxicity in hepatocytes.Nov 27, 2019

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Pubmed Data : Nutrients. 2019 Nov 28 ;11(12). Epub 2019 Nov 28. PMID: 31795130

Article Published Date : Nov 27, 2019

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Apoptotic, Hepatoprotective, Hypolipidemic

[+]

Lotus seedpod proanthocyanidins protect against neurotoxicity after methyl-mercuric chloride injury.Nov 14, 2019

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Pubmed Data : Ecotoxicol Environ Saf. 2019 Nov 15 ;183:109560. Epub 2019 Aug 14. PMID: 31421536

Article Published Date : Nov 14, 2019

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation

Additional Keywords : Proanthocyanidins

Problem Substances : Mercury

[+]

Lotus stamen has antioxidant properties.Apr 01, 2003

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Pubmed Data : Arch Pharm Res. 2003 Apr;26(4):279-85. PMID: 12735685

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Pubmed Data : Arch Pharm Res. 2015 Jun ;38(6):1178-87. Epub 2014 Oct 11. PMID: 25300425

Article Published Date : May 31, 2015

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Cholinesterase Inhibitors

Additional Keywords : Plant Extracts

[+]

Neferine ameliorates cardiomyoblast apoptosis induced by doxorubicin.Sep 24, 2017

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Pubmed Data : Food Chem Toxicol. 2017 May ;103:28-40. Epub 2017 Feb 20. PMID: 28223119

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Pubmed Data : Redox Rep. 2021 Dec ;26(1):1-9. PMID: 33416009

Article Published Date : Nov 30, 2021

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Prostatic Hyperplasia: Benign

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

[+]

Neferine increases sensitivities to multiple anticancer drugs via downregulation of Bcl-2 expression in renal cancer cells.Jan 15, 2022

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Pubmed Data : Genes Genomics. 2022 Jan 16. Epub 2022 Jan 16. PMID: 35034280

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Pubmed Data : J Environ Pathol Toxicol Oncol. 2021 ;40(3):51-61. PMID: 34587404

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Breast Cancer, Breast Cancer: Chemically-Induced

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Neferine inhibits growth and migration of gastrointestinal stromal tumor cell line GIST-T1.Dec 31, 2018

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Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:1032-1040. Epub 2018 Nov 6. PMID: 30551353

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Glioma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

[+]

Neferine inhibits the development of lung cancer cells by downregulating TGF-β to regulate MST1/ROS-induced pyroptosis.Oct 31, 2023

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Neferine promotes the apoptosis of HNSCC through the accumulation of p62/SQSTM1 caused by autophagic flux inhibition.Dec 31, 2020

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Pubmed Data : Int J Mol Med. 2021 07 ;48(1). Epub 2021 May 13. PMID: 33982791

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Head and Neck Cancer

Pharmacological Actions : Apoptotic

[+]

Neferine protected cardiomyocytes against hypoxia/oxygenation injury.Jul 31, 2023

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Pubmed Data : J Biochem Mol Toxicol. 2023 Aug ;37(8):e23398. Epub 2023 Jul 8. PMID: 37421224

Article Published Date : Jul 31, 2023

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Myocardial Infarction, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation, SIRT1 Activator

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Neferine reduces cisplatin-induced nephrotoxicity by enhancing autophagy.Mar 10, 2017

Pubmed Data : Phytother Res. 2020 May 4. Epub 2020 May 4. PMID: 32364634

Article Published Date : May 03, 2020

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Cervical Cancer

Pharmacological Actions : Apoptotic, Autophagy Up-regulation

[+]

Neferine targets the oncogenic characteristics of androgen-dependent prostate cancer cells.Sep 17, 2023

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Pubmed Data : Int J Mol Sci. 2023 Sep 18 ;24(18). Epub 2023 Sep 18. PMID: 37762540

Article Published Date : Sep 17, 2023

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Prostate Cancer

Pharmacological Actions : Apoptotic

[+]

Neferine treatment enhances the TRAIL-induced apoptosis of human prostate cancer cells.Apr 30, 2020

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Pubmed Data : Food Funct. 2020 Oct 21 ;11(10):8602-8611. PMID: 33084700

Article Published Date : Oct 20, 2020

Study Type : In Vitro Study

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Substances : Gallic Acid, Lotus , Polyphenols

Diseases : Atherosclerosis

Pharmacological Actions : MicroRNA modulator

[+]

Nelumbo nucifera leaves prevent NMU-induced mammary tumor.Dec 31, 2018

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Pubmed Data : Food Funct. 2021 Jul 5 ;12(13):5850-5861. PMID: 34018523

Article Published Date : Jul 04, 2021

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Obesity

Pharmacological Actions : Autophagy Up-regulation, Gastrointestinal Agents

Additional Keywords : Anti-Obesity Agents

[+]

Nuciferine inhibited the differentiation and lipid accumulation of 3T3-L1 preadipocytes.Dec 31, 2020

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Pubmed Data : Front Pharmacol. 2021 ;12:632236. Epub 2021 Mar 22. PMID: 33841152

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Dyslipidemias, Obesity

Pharmacological Actions : Hypolipidemic

Additional Keywords : Anti-Obesity Agents, Gene Expression Regulation

[+]

Nuciferine inhibits proinflammatory cytokines via the PPARs in LPS-induced RAW264.7 cells.Oct 21, 2018

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Pubmed Data : J Agric Food Chem. 2022 Mar 30 ;70(12):3687-3696. Epub 2022 Mar 17. PMID: 35298888

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Pubmed Data : Prev Nutr Food Sci. 2015 Mar ;20(1):22-8. Epub 2015 Mar 31. PMID: 25866746

Article Published Date : Feb 28, 2015

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Cytoprotective

Additional Keywords : Plant Extracts

[+]

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Pubmed Data : Molecules. 2022 Nov 23 ;27(23). Epub 2022 Nov 23. PMID: 36500241

Article Published Date : Nov 22, 2022

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Aging Skin, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation

[+]

Procyanidins from lotus seedpod induced autophagy and autophagic cell death in HepG2 cells.Mar 31, 2016

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Pubmed Data : Biomed Pharmacother. 2016 Apr ;79:135-52. Epub 2016 Feb 22. PMID: 27044822

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Pubmed Data : J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 1 ;1040:186-191. Epub 2016 Dec 12. PMID: 27987489

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Anti-Inflammatory Agents, Dose Response, Inflammation, Lipopolysaccharide-Induced Toxicity, Lotus

[+]

Reversal of cisplatin resistance by neferine/isoliensinine and their combinatorial regimens with cisplatin-induced apoptosis in cisplatin-resistant colon cancer stem cells.Dec 16, 2021

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Pubmed Data : J Biochem Mol Toxicol. 2021 Dec 17:e22967. Epub 2021 Dec 17. PMID: 34921482

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These results suggested the potential of neferine as a therapeutic agent for acute respiratory distress syndrome.Dec 31, 2017

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Pubmed Data : Front Physiol. 2018 ;9:102. Epub 2018 Feb 22. PMID: 29520236

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Acute Respiratory Distress Syndrome, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents

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These results validate the traditional use of Nelumbo Nucifera leaves for the management of diabetes.Jan 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Tradit Chin Med. 2016 Feb ;36(1):71-7. PMID: 26946622

Article Published Date : Jan 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Diabetes Mellitus: Type 1

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic, Insulin-releasing, Interleukin-1 beta downregulation

Additional Keywords : Plant Extracts

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This study suggests the use of neferine for amelioration of doxorubicin -mediated cardiotoxicity.Jul 20, 2017

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Pubmed Data : J Cell Biochem. 2017 Jul 21. Epub 2017 Jul 21. PMID: 28731223

Article Published Date : Jul 20, 2017

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Cardioprotective, Chemoprotective Agents

Additional Keywords : Cardioprotective, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Doxorubicin, Lotus

[+]

Unveiling the potential of Nelumbo nucifera-derived liensinine to target the myostatin protein and to counteract muscle atrophy.Jan 30, 2024

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Pubmed Data : J Agric Food Chem. 2024 Jan 31 ;72(4):2240-2249. Epub 2024 Jan 23. PMID: 38258624

Article Published Date : Jan 30, 2024

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Muscle Atrophy

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View the Evidence: 258 Abstracts with Lotus Research

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Combined topical application of lotus and green tea improves facial skin surface parameters.Mar 31, 2013

Fat reducing effects of Nelumbo nucifera leaf extract in overweight patients.Dec 01, 2021

Mixture of Rhodiola rosea and Nelumbo nucifera extracts ameliorates sleep quality of adults with sleep disturbance.Jun 13, 2024

Neferine exerts a cytoprotective effect against hypoxia-induced oxidative stress and inflammation in human peripheral blood mononuclear cells.Jul 08, 2017

Hypoglycemic activity in vivo and in vitro of lotus.Jun 29, 2024

In vitro and in vivo nephroprotective effects of Nelumbo nucifera seedpod extract against cisplatin-induced renal injury.Dec 01, 2022

Neferine ameliorates nonalcoholic steatohepatitis through regulating AMPK pathway.May 31, 2023

Nrf2 activation by neferine mitigates microglial neuroinflammation after subarachnoid hemorrhage.Mar 29, 2024

Nuciferine attenuates doxorubicin-induced cardiotoxicity. Jan 10, 2021

Neuroprotective effect of white Nelumbo nucifera petal tea in rats poisoned with mancozeb.May 27, 2023

A compound found within Lotus flower may positively modulate immune function in autoimmune disease like systemic lupus erythematosus. Feb 15, 2006

A dietary supplement of nuciferine rich in lotus leaf may have potential for the prevention and treatment of hyperuricemia with kidney inflammation.Jan 14, 2015

A multiple-targets alkaloid nuciferine overcomes paclitaxel-induced drug resistance in vitro and in vivo.Sep 09, 2020

Alkaloids extracted from lotus leaves might be a new complementary treatment to treat abnormal contractions of the trachea and asthma.Mar 19, 2017

An combined extract of lotus, white mulberry and radish may be a natural anti-obesity agent.May 18, 2019

Anti-Alzheimer and antioxidant effects of Nelumbo nucifera L. alkaloids, nuciferine and norcoclaurine.Sep 27, 2022

Anti-obesity and antidiabetic effects of nelumbinis semen powder in high-fat diet-induced obese.Nov 21, 2020

Anti-obesity effects of a Prunus persica and Nelumbo nucifera mixture in mice fed a high-fat diet.Nov 03, 2020

Antioxidant and inflammatory effects of Nelumbo nucifera leaves.Dec 31, 2020

Chemomodulatory effect of neferine on DMBA-induced squamous cell carcinogenesis.Nov 05, 2020

Distinct AMPK-mediated FAS/HSL pathway is implicated in the alleviating effect of nuciferine on obesity and hepatic steatosis.Apr 29, 2022

Effects and action mechanisms of lotus leaf ethanol extract on gut microbes and obesity in a high-fat diet.Dec 31, 2022

Effects of Nelumbo nucifera leaf extract on obesity. Aug 31, 2021

Evaluation of antiinflammatory activity of ethanol extract of Nelumbo nucifera fruit.Feb 24, 2021

Extracellular vesicle delivery of neferine for the attenuation of neurodegenerative disease proteins.Jan 09, 2022

Extracts from Nelumbo nucifera leaves had significantly hepatoprotective effect for Calcium tetrachloride CCl4-induced liver injury.Dec 31, 2013

GABA contained in lotus seed extract acts as a sleep potentiating compound.Feb 28, 2021

Isoliensinine from Nelumbo nucifera induces hepatocellular carcinoma cell apoptosis.Oct 13, 2015

Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model.Feb 14, 2023

Long-term intake of the lotus seed tea showed the effect of preventing loss of skin moisture, mitigating the formation of abnormal keratinocytes.Aug 31, 2015

Lotus flower leaf has anti-obesity effects in mice.Jun 09, 2010

Lotus has antipyretic properties.Jun 01, 2000

Lotus has immunomodulatory effects. Jan 05, 2010

Lotus leaf hot water extract with taurine supplementation showed antiobesity and hypolipidemic effects in high fat diet-induced obese rats.Jun 23, 2006

Lotus leaves have an anti-obesity effect in mice. Feb 01, 2008

Lotus procyanidins reverse memory impairments in cognitivitely impaired aged rats.Sep 01, 2010

Lotus root extract with taurine has an antioxidant and hepatoprotective effect in rats fed a high fat diet.Jan 01, 2010

Lotus seed extract has a hypoglycemic effect in diabetic rats.Nov 01, 2004

Lotus seed extract improves memory in cognitively impaired aged rats.Dec 01, 2009

Lotus seed procyanidins prevent oxidative stress by extremely low frequency electromagnetic fields in mice.Aug 01, 2016

Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway.Dec 31, 2018

Lotus seedpod proanthyocyanins have an ameliorative effect on cognitive deficits and oxidative damage in senescence-accelerated mice.Dec 01, 2008

Lotus seedpod procyanidins mitigate the oxidative effects and learning and memory damage caused by extremely low frequency electromagnetic fields onAug 01, 2013

Lotus stamen has aldose reductase inhibitory which may have value in preventing diabetes-associated eye damage. Oct 01, 2006

N. nucifera extract is the potential neuroprotective and memory enhancing agent. Dec 31, 2015

N. nucifera fruit exhibited strong anxiolytic and antidepressant effects.Jan 31, 2017

N. nucifera fruit may be valuable in managing epilepsy.Aug 02, 2017

Neferine alleviates acute kidney injury by regulating the PPAR-α/NF-κB pathway.Apr 23, 2024

Neferine alleviates memory and cognitive dysfunction in diabetes.Jun 30, 2020

Neferine alleviates neuropathic pain by downregulating the expression of P2X3 receptor.Aug 31, 2020

Neferine alleviates ovalbumin-induced asthma.Dec 31, 2022

Neferine alleviates ovariectomy-induced osteoporosis by enhancing osteogenic differentiation of bone marrow mesenchymal stem cells.May 15, 2024

Neferine ameliorates dextran sulfate sodium-induced ulcerative colitis.Dec 31, 2017

Neferine appeared to suppress prostate growth by regulating the EMT, AR and TGF-β/Smad signaling pathways.Jun 30, 2023

Neferine exerted remarkable protection against cerebral ischemia.Sep 07, 2021

Neferine exerts anti‑inflammatory activity in BV‑2 microglial cells and protects mice with MPTP‑induced Parkinson's disease.Nov 30, 2023

Neferine extracted from Lotus seed has sedative anti-anxiety effects.Dec 01, 2008

Neferine had an antifibrosis effect on carbon tetrachloride-induced hepatic fibrosis in mice.Dec 31, 2014

Neferine is an attractive reagent with great potential in high-grade serous ovarian carcinoma therapy.Sep 27, 2018

Neferine may have antifibrogenic effects in diabetes-related cardiac fibrosis.Sep 19, 2016

Neferine may serve as an effective regulator during the pathogenesis of vascular inflammatory diseases.Jan 14, 2020

Neferine might have therapeutic potential for ischaemic stroke Nov 09, 2018

Neferine mitigated renal injury in acute kidney injury models.Dec 31, 2018

Neferine pretreatment attenuates isoproterenol-induced cardiac injury.Mar 24, 2024

Neferine protects against hypoxic-ischemic brain damage.Dec 31, 2020

Neferine significantly promotes a fast and efficient wound healing.Nov 30, 2020

Neferine targeted the NLRC5/NLRP3 pathway to inhibit M1-type polarization and pyroptosis of macrophages to improve hyperuricemic nephropathy.Feb 15, 2024

Neferine, a compound extracted from Nulembo nucifera, has a similar effect to rosiglitazone (Avandia) in decreasing fasting blood glucose, insulin, TG, TNF-alpha and enhancing insulin sensitivity in insulin resistant rats.Jul 06, 2009

Neferine, an alkaloid from lotus seed embryos, exerts antiseizure and neuroprotective effects.Apr 07, 2022

Nelumbo nucifera contains a compound which exhibits vitro and in vivo antifibrotic effects in rats with liver fibrosis. Sep 02, 2009

Nelumbo nucifera extract exhibits anti-atherogenic activity by inhibiting the proliferation and migration of vascular smooth muscle cells in an animal model of atherosclerosis. Sep 30, 2009

Nelumbo nucifera fruit seems to have great potential for therapeutic application in memory disorders.Sep 30, 2018

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View the Evidence:
258 Abstracts with Lotus Research