Lupeol

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62 Diseases Researched for Lupeol
NameACCKFocus
Cancers: All424Locked
Oxidative Stress611Locked
Inflammation58Locked
Hyperglycemia47Locked
Lipopolysaccharide-Induced Toxicity36Locked
Alzheimer's Disease35Locked
Diabetic Complications35Locked
Leishmaniasis35Locked
Wound Healing35Locked
Arthritis24Locked
Cerebral Ischemia24Locked
Chemically-Induced Liver Damage24Locked
Liver Cancer44Locked
Polycystic Ovary Syndrome24Locked
Prostate Cancer34Locked
Colorectal Cancer33Locked
Lung Cancer33Locked
Myocarditis: Autoimmune13Locked
Nasopharyngeal Cancer13Locked
Neurodegenerative Diseases23Locked
Pesticide Toxicity 23Locked
Atopic Dermatitis12Locked
Brain Inflammation 12Locked
Breast Cancer: Triple Negative 22Locked
Cancer Metastasis22Locked
Cancers: Drug Resistant22Locked
Cardiac Hypertrophy12Locked
Cardiomegaly12Locked
Chemotherapy12Locked
Cholangiocarcinoma12Locked
Dementia12Locked
Diabetes Mellitus: Type 112Locked
Diabetes Mellitus: Type 212Locked
Diabetes: Cognitive Dysfunction12Locked
Gastric Cancer12Locked
Head and Neck Cancer12Locked
Hypercholesterolemia12Locked
Ischemia12Locked
Kidney Damage12Locked
Liver Disease12Locked
Lymph node carcinoma of the prostate (LNCaP)12Locked
Myocardial Infarction12Locked
Nonalcoholic fatty liver disease (NAFLD)12Locked
Osteosarcoma22Locked
Parkinson's Disease12Locked
Skin Cancer: Prevention12Locked
Traumatic Brain Injury12Locked
Aging Skin11Locked
Cervical Cancer11Locked
Herpes Simplex Virus Type 111Locked
Kidney Cancer11Locked
Leukemia11Locked
Liver Damage11Locked
Malaria11Locked
Melanoma11Locked
Methicillin-resistant Staphylococcus aureus11Locked
Non-Small-Cell Lung Carcinoma11Locked
Oral Cancer11Locked
Retinoblastoma11Locked
Skin Cancer11Locked
Squamous cell carcinoma11Locked
Ultraviolet Radiation Induced Damage11Locked
51 Pharmacological Actions Researched for Lupeol
NameACCKFocus
Anti-Inflammatory Agents1936Locked
Chemotherapeutic121Locked
Apoptotic1519Locked
Antioxidants917Locked
Antiproliferative 1416Locked
NF-kappaB Inhibitor815Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor714Locked
Neuroprotective Agents59Locked
Interleukin-1 beta downregulation48Locked
Anti-Apoptotic47Locked
Hepatoprotective47Locked
Hypoglycemic Agents47Locked
Chemosensitizer56Locked
Immunomodulatory46Locked
Interleukin-6 Downregulation36Locked
Nrf2 activation36Locked
Cyclooxygenase 2 Inhibitors35Locked
Cardioprotective24Locked
Hypolipidemic24Locked
Alpha-amylase inhibitor23Locked
Alpha-glucosidase inhibitor 23Locked
Anti-Bacterial Agents23Locked
Anti-metastatic33Locked
Bcl-2 protein down-regulation23Locked
Leishmanicidal23Locked
Angiogenesis Inhibitors12Locked
Anti-Fibrotic12Locked
Anticarcinogenic Agents12Locked
Antiparasitic Agents12Locked
Cell cycle arrest22Locked
Chemopreventive12Locked
Chemoprotective Agents12Locked
Interleukin-10 upregulation12Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor22Locked
Renoprotective12Locked
Survivin Down-Regulation12Locked
Transforming growth factor beta (TGF-β) inhibitor12Locked
Tumor Suppressor Protein p53 Upregulation12Locked
Antimalarials11Locked
Antineoplastic Agents11Locked
Antiviral Agents11Locked
Autophagy Up-regulation11Locked
Cytoprotective11Locked
Epidermal growth factor receptor (EGFR) inhibitor11Locked
Genoprotective11Locked
Matrix metalloproteinase-1 (MMP-1) inhibitor11Locked
Matrix metalloproteinase-3 (MMP-3) inhibitor11Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor11Locked
Radiosensitizer11Locked
STAT3 Inhibitor11Locked
Wnt/β-catenin signaling pathway modulation11Locked

View the Evidence:
68 Abstracts with Lupeol Research

[+]

Chemotherapeutic potential of lupeol against cancer in pre-clinical model.May 30, 2024

Pubmed Data : Phytomedicine. 2024 May 31 ;132:155777. Epub 2024 May 31. PMID: 38943695
Article Published Date : May 30, 2024
Study Type : Meta Analysis, Review
Additional Links
Substances : Lupeol
Diseases : Cancers: All
Pharmacological Actions : Chemotherapeutic
[+]

Lupeol alleviates autoimmune myocarditis.Nov 07, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytomedicine. 2023 Nov 8 ;123:155193. Epub 2023 Nov 8. PMID: 37976692
Article Published Date : Nov 07, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Myocarditis: Autoimmune
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, NF-kappaB Inhibitor
[+]

Lupeol triggers oxidative stress, ferroptosis, apoptosis and restrains inflammation in nasopharyngeal carcinoma.Jul 31, 2022

Pubmed Data : Immunopharmacol Immunotoxicol. 2022 Aug ;44(4):621-631. Epub 2022 May 16. PMID: 35486494
Article Published Date : Jul 31, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, NF-kappaB Inhibitor
[+]

Alleviating effects of lupeol on postprandial hyperglycemia in diabetic mice.Apr 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Res (Camb). 2021 May ;10(3):495-500. Epub 2021 May 8. PMID: 34141163
Article Published Date : Apr 30, 2021
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Hyperglycemia
Pharmacological Actions : Alpha-amylase inhibitor, Alpha-glucosidase inhibitor , Hypoglycemic Agents
[+]

Amelioration of oxidative stress mediated inflammation and apoptosis in pancreatic islets by Lupeol.Sep 14, 2022

Pubmed Data : Life Sci. 2022 Sep 15 ;305:120769. Epub 2022 Jul 2. PMID: 35792182
Article Published Date : Sep 14, 2022
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Beneficial effect of lupeol and metformin in mouse model of intracerebroventricular streptozotocin induced dementia.May 31, 2024

Pubmed Data : Metab Brain Dis. 2024 Jun ;39(5):661-678. Epub 2024 Jun 6. PMID: 38842663
Article Published Date : May 31, 2024
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Alzheimer's Disease, Dementia, Diabetes: Cognitive Dysfunction, Oxidative Stress
Pharmacological Actions : Neuroprotective Agents
[+]

Implication of Lupeol in compensating Sorafenib-induced perturbations of redox homeostasis.May 31, 2023

Pubmed Data : Life Sci. 2023 Jun 1 ;322:121647. Epub 2023 Apr 1. PMID: 37011877
Article Published Date : May 31, 2023
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Chemotherapy, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Lupeol acetate significantly improves the symptoms of RA by down-regulating expressions of inflammatory cytokines and osteoclastogenesis.Mar 31, 2016

Pubmed Data : Biomed Pharmacother. 2016 Apr ;79:231-40. Epub 2016 Mar 11. PMID: 27044833
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Arthritis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
[+]

Lupeol alleviates atopic dermatitis-like skin inflammation.Apr 24, 2023

Pubmed Data : BMC Pharmacol Toxicol. 2023 Apr 25 ;24(1):27. Epub 2023 Apr 25. PMID: 37098554
Article Published Date : Apr 24, 2023
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Atopic Dermatitis, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Lupeol alleviates cerebral ischemia-reperfusion injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neuropsychiatr Dis Treat. 2020 ;16:1381-1390. Epub 2020 Jun 2. PMID: 32581541
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Lupeol alleviates myocardial ischemia-reperfusion injury.Dec 31, 2021

Pubmed Data : Am J Chin Med. 2022 ;50(5):1269-1280. Epub 2022 Jun 4. PMID: 35670060
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Myocardial Infarction
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Nrf2 activation
[+]

Lupeol ameliorates LPS/D-GalN induced acute hepatic damage by suppressing inflammation and oxidative stress.Mar 10, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging (Albany NY). 2021 Mar 11 ;13(5):6592-6605. Epub 2021 Mar 11. PMID: 33707345
Article Published Date : Mar 10, 2021
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Chemically-Induced Liver Damage, Inflammation, Lipopolysaccharide-Induced Toxicity, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Nrf2 activation, Transforming growth factor beta (TGF-β) inhibitor
[+]

Lupeol and amphotericin B mediate synergistic anti-leishmanial immunomodulatory effects.Dec 31, 2020

Pubmed Data : Cytokine. 2021 Jan ;137:155319. Epub 2020 Sep 29. PMID: 33002744
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Leishmaniasis
Pharmacological Actions : Immunomodulatory, Leishmanicidal
Additional Keywords : Natural Substance/Drug Synergy
[+]

Lupeol and mango extract induces programmed cell death in mouse prostate and lymph node carcinoma of the prostate. Jan 01, 2008

Pubmed Data : Nutr Cancer. 2008;60(1):120-30. PMID: 18444143
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Lupeol, Mango
Diseases : Lymph node carcinoma of the prostate (LNCaP), Prostate Cancer
[+]

Lupeol and stigmasterol suppress tumor angiogenesis and inhibit cholangiocarcinoma growth.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(12):e0189628. Epub 2017 Dec 12. PMID: 29232409
Article Published Date : Dec 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lupeol, Stigmasterol
Diseases : Cholangiocarcinoma
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Lupeol attenuated the NAFLD and PCOS-induced metabolic, oxidative, hormonal, histopathological, and molecular injuries.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Res Pharm Sci. 2023 ;18(5):551-565. Epub 2023 Aug 20. PMID: 37842512
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Nonalcoholic fatty liver disease (NAFLD), Polycystic Ovary Syndrome
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hypolipidemic
[+]

Lupeol could be a novel compound in the treatment of polycystic ovary syndrome.Dec 31, 2023

Pubmed Data : Iran J Basic Med Sci. 2024 ;27(8):1067-1076. PMID: 38911242
Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Polycystic Ovary Syndrome
Pharmacological Actions : Anti-Fibrotic
[+]

Lupeol enhances inhibitory effect of 5-fluorouracil on human gastric carcinoma cells.Apr 30, 2016

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2016 May ;389(5):477-84. Epub 2016 Feb 19. PMID: 26892272
Article Published Date : Apr 30, 2016
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, Survivin Down-Regulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Lupeol enhances wound healing in streptozotocin-induced hyperglycaemia.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:3182627. Epub 2019 May 9. PMID: 31210838
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Diabetic Complications, Hyperglycemia, Wound Healing
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-10 upregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor
[+]

Lupeol improves bile acid metabolism and metabolic dysfunction-associated steatotic liver disease.Jun 16, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2024 Jun 17 ;177:116942. Epub 2024 Jun 17. PMID: 38889641
Article Published Date : Jun 16, 2024
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Liver Disease
Pharmacological Actions : Hepatoprotective
Additional Keywords : Gut-liver axis
[+]

Lupeol induces immunity and protective efficacy in a murine model against visceral leishmaniasis.Aug 31, 2019

Pubmed Data : Parasitology. 2019 Sep ;146(11):1440-1450. Epub 2019 Jun 13. PMID: 31104636
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Leishmaniasis
Pharmacological Actions : Antiparasitic Agents, Immunomodulatory
[+]

Lupeol inhibits LPS-induced neuroinflammation in cerebellar cultures and induces neuroprotection.Apr 30, 2019

Pubmed Data : Int Immunopharmacol. 2019 May ;70:302-312. Epub 2019 Mar 7. PMID: 30852286
Article Published Date : Apr 30, 2019
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Alzheimer's Disease, Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Lupeol inhibits pesticides induced hepatotoxicity via reducing oxidative stress and inflammatory markers.May 31, 2022

Pubmed Data : Food Chem Toxicol. 2022 Jun ;164:113068. Epub 2022 Apr 26. PMID: 35483487
Article Published Date : May 31, 2022
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Chemically-Induced Liver Damage, Oxidative Stress, Pesticide Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Pesticides
[+]

Lupeol may orchestrate a bifurcated regulation of neoplastic growth and apoptosis in head and neck cancers.Mar 31, 2017

Pubmed Data : Cell Oncol (Dordr). 2017 Apr ;40(2):145-155. Epub 2016 Dec 30. PMID: 28039610
Article Published Date : Mar 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Head and Neck Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Lupeol protects against cardiac hypertrophy.Jul 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharmacol Sin. 2022 Aug ;43(8):1989-2002. Epub 2021 Dec 16. PMID: 34916609
Article Published Date : Jul 31, 2022
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Cardiac Hypertrophy, Cardiomegaly
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Lupeol treatment attenuates activation of glial cells and oxidative-stress-mediated neuropathology in mouse model of traumatic brain injury.May 28, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2022 May 29 ;23(11). Epub 2022 May 29. PMID: 35682768
Article Published Date : May 28, 2022
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Inflammation, Neurodegenerative Diseases, Oxidative Stress, Traumatic Brain Injury
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Lupeol-loaded chitosan-Ag+ nanoparticle/sericin hydrogel accelerates wound healing and effectively inhibits bacterial infection.Jul 14, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Macromol. 2023 Jul 15 ;243:125310. Epub 2023 Jun 12. PMID: 37315678
Article Published Date : Jul 14, 2023
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Wound Healing
Pharmacological Actions : Anti-Bacterial Agents
[+]

Protective effect of lupeol on arthritis induced by type II collagen.Jun 30, 2022

Pubmed Data : Environ Toxicol. 2022 Jul ;37(7):1814-1822. Epub 2022 Apr 21. PMID: 35446470
Article Published Date : Jun 30, 2022
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Protective effects of lupeol in rats with renal ischemia‑reperfusion injury.Jul 31, 2024

Pubmed Data : Exp Ther Med. 2024 Aug ;28(2):313. Epub 2024 Jun 7. PMID: 38911048
Article Published Date : Jul 31, 2024
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Ischemia, Kidney Damage
Pharmacological Actions : Renoprotective
[+]

Results of the study affirmed the antidiabetic activities of lupeol and iso-orientin.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2019 ;13:1501-1513. Epub 2019 May 6. PMID: 31123393
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents
[+]

The combination of pterostilbene and lupeol was more effective in prevention of skin cancer as compared to either of the phytochemical alone.Dec 31, 2016

Pubmed Data : Food Chem Toxicol. 2017 Jan ;99:182-189. Epub 2016 Nov 9. PMID: 27836749
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Lupeol, Pterostilbene
Diseases : Skin Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Natural Substance Synergy
Problem Substances : Benzo(a)pyrene
[+]

The data suggest that lupeol may exert protective effects against cerebral ischemia.May 31, 2020

Pubmed Data : Metab Brain Dis. 2020 Jun ;35(5):841-848. Epub 2020 Mar 24. PMID: 32212043
Article Published Date : May 31, 2020
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Umbelliferone and Lupeol could be potential antidiabetic herbal remedies in the management of diabetes and its associated complications.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(3):e0151135. Epub 2016 Mar 22. PMID: 27003006
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Banana, Lupeol
Diseases : Diabetic Complications, Hypercholesterolemia, Hyperglycemia
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic
Additional Keywords : Phytotherapy, Plant Extracts
[+]

A triterpenoid lupeol as an antioxidant and anti-neuroinflammatory agent.Jul 06, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2023 Jul 7 ;15(13). Epub 2023 Jul 7. PMID: 37447385
Article Published Date : Jul 06, 2023
Study Type : Review
Additional Links
Substances : Lupeol
Diseases : Alzheimer's Disease, Neurodegenerative Diseases, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Anti-metastatic effects of lupeol via the inhibition of MAPK/ERK pathway in lung cancer.Apr 23, 2020

Pubmed Data : Anticancer Agents Med Chem. 2020 Apr 24. Epub 2020 Apr 24. PMID: 32329697
Article Published Date : Apr 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Lung Cancer
Pharmacological Actions : Anti-metastatic
Additional Keywords : Gene Expression Regulation
[+]

Antileishmanial and immunomodulatory activities of lupeol.Sep 30, 2017

Pubmed Data : Int J Antimicrob Agents. 2017 Oct ;50(4):512-522. Epub 2017 Jun 29. PMID: 28669838
Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Leishmaniasis
Pharmacological Actions : Immunomodulatory, Leishmanicidal
Additional Keywords : Plant Extracts
[+]

Antileukemic cell proliferation of active compounds from kaffir lime.Mar 11, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Mar 12 ;25(6). Epub 2020 Mar 12. PMID: 32178481
Article Published Date : Mar 11, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lime, Lupeol
Diseases : Leukemia
Pharmacological Actions : Antiproliferative , Cell cycle arrest
[+]

Geraniol and lupeol inhibit growth and promote apoptosis in human hepatocarcinoma cells.Mar 31, 2019

Pubmed Data : J Cell Biochem. 2019 Apr ;120(4):5033-5041. Epub 2018 Dec 2. PMID: 30506710
Article Published Date : Mar 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Geraniol , Lupeol
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Investigation of lupeol as anti-melanoma agent.Dec 01, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Curr Oncol. 2021 Dec 2 ;28(6):5054-5066. Epub 2021 Dec 2. PMID: 34940064
Article Published Date : Dec 01, 2021
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Melanoma, Skin Cancer
Pharmacological Actions : Apoptotic
[+]

Lupeol against high-glucose-induced apoptosis via enhancing the anti-oxidative stress in rabbit nucleus pulposus cells.Jul 13, 2018

Pubmed Data : Eur Spine J. 2018 Jul 14. Epub 2018 Jul 14. PMID: 30008063
Article Published Date : Jul 13, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Diabetic Complications
Pharmacological Actions : Anti-Apoptotic
[+]

Lupeol can be used in anti-metastasis of human osteosarcoma cells.Aug 31, 2019

Pubmed Data : Biosci Biotechnol Biochem. 2019 Sep ;83(9):1729-1739. Epub 2019 Apr 22. PMID: 31010399
Article Published Date : Aug 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Cancer Metastasis, Osteosarcoma
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Lupeol could be used as a potent anti-oxidant regimen against pesticide induced genotoxicity in agricultural farm workers.Jun 14, 2016

Pubmed Data : Phytomedicine. 2016 Jun 15 ;23(7):714-24. Epub 2016 Apr 11. PMID: 27235710
Article Published Date : Jun 14, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Pesticide Toxicity
Pharmacological Actions : Cytoprotective, Genoprotective
Problem Substances : Pesticides
[+]

Lupeol enhances the chemosensitivity of prostate cancer stem cells to antiandrogen enzalutamide-based therapy.Oct 31, 2023

Pubmed Data : Toxicol Appl Pharmacol. 2023 Nov 1 ;478:116699. Epub 2023 Sep 28. PMID: 37777120
Article Published Date : Oct 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Cancers: Drug Resistant, Prostate Cancer
Pharmacological Actions : Chemosensitizer
[+]

Lupeol has potential to be an effective agent against renal cell carcinoma with the modulation of mitochondrial dynamics.Jul 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2019 Aug ;5(8):e02107. Epub 2019 Aug 2. PMID: 31417967
Article Published Date : Jul 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Kidney Cancer
Pharmacological Actions : Apoptotic
[+]

Lupeol impairs herpes simplex virus type 1 replication.Dec 31, 2020

Pubmed Data : Acta Virol. 2021 ;65(3):254-263. PMID: 34565153
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Herpes Simplex Virus Type 1
Pharmacological Actions : Antiviral Agents
Additional Keywords : Gene Expression Regulation
[+]

Lupeol induces autophagy and apoptosis with reduced cancer stem-like properties in retinoblastoma.Jan 31, 2022

Pubmed Data : J Pharm Pharmacol. 2022 Feb 1 ;74(2):208-215. PMID: 33836050
Article Published Date : Jan 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Retinoblastoma
Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation
Additional Keywords : Cancer Stem Cells
[+]

Lupeol induces S-phase arrest and mitochondria-mediated apoptosis in cervical cancer cells.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biosci. 2018 Jun ;43(2):249-261. PMID: 29872014
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Lupeol inhibits growth and migration in two human colorectal cancer cell lines by suppression of Wnt-β-catenin pathway.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2018 ;11:7987-7999. Epub 2018 Nov 9. PMID: 30519040
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Wnt/β-catenin signaling pathway modulation
[+]

Lupeol inhibits human hepatocellular carcinoma cells.Jan 01, 2011

Pubmed Data : Biol Pharm Bull. 2011 ;34(4):517-22. PMID: 21467639
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Plant Extracts
[+]

Lupeol inhibits migration and invasion of colorectal cancer cells.Feb 05, 2020

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2020 Feb 6. Epub 2020 Feb 6. PMID: 32025757
Article Published Date : Feb 05, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic
[+]

Lupeol inhibits osteosarcoma progression by up-regulation of HMGA2 via regulating miR-212-3p.Sep 02, 2020

Pubmed Data : J Orthop Surg Res. 2020 Sep 3 ;15(1):374. Epub 2020 Sep 3. PMID: 32883329
Article Published Date : Sep 02, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Cancer Metastasis, Osteosarcoma
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
[+]

Lupeol inhibits the proliferation and migration of MDA-MB-231 breast cancer cells.May 09, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Funct. 2022 May 10 ;13(9):4967-4976. Epub 2022 May 10. PMID: 35448900
Article Published Date : May 09, 2022
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative
[+]

Lupeol is one of active compounds in the CH2Cl2 fraction of Chrysanthemum indicum that inhibits LMP1-induced NF-κB activation.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(11):e82688. Epub 2013 Nov 26. PMID: 24303085
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Chrysanthemum Indicum, Lupeol
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

Lupeol may act as a potent inhibitor of the EGFR signalling in oral squamous cell carcinoma.May 31, 2016

Pubmed Data : Mol Cell Biochem. 2016 Jun ;417(1-2):97-110. Epub 2016 May 20. PMID: 27206736
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Lupeol may be useful as an anti-aging agent.Feb 28, 2019

Pubmed Data : Photochem Photobiol. 2019 Mar ;95(2):587-594. Epub 2018 Nov 2. PMID: 30257039
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Aging Skin, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor
[+]

Lupeol served as a strong chemoresistant sensitizer and could be a new adjuvant therapy method for chemoresistant patients.Apr 30, 2018

Pubmed Data : Environ Toxicol. 2018 May ;33(5):587-593. Epub 2018 Feb 13. PMID: 29436100
Article Published Date : Apr 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Cancers: Drug Resistant, Colorectal Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer
[+]

Lupeol suppresses plasminogen activator inhibitor-1-mediated macrophage recruitment and attenuates M2 macrophage polarization.Jul 04, 2020

Pubmed Data : Biochem Biophys Res Commun. 2020 Jul 5 ;527(4):889-895. Epub 2020 May 16. PMID: 32430175
Article Published Date : Jul 04, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Cancers: All, Lung Cancer
Pharmacological Actions : Immunomodulatory
Additional Keywords : Tumor Microenvironment
[+]

Lupeol synergizes with 5-fluorouracil to combat c-MET/EphA2 mediated chemoresistance in triple negative breast cancer.Dec 14, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : iScience. 2023 Dec 15 ;26(12):108395. Epub 2023 Nov 4. PMID: 38047085
Article Published Date : Dec 14, 2023
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Lupeol triterpene exhibits potent antitumor effects in A427 human lung carcinoma cells.Apr 30, 2018

Pubmed Data : J BUON. 2018 May-Jun;23(3):635-640. PMID: 30003730
Article Published Date : Apr 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic
[+]

Lupeol-loaded nanoparticles enhance the radiosensitivity of hepatocellular carcinoma.Oct 31, 2021

Pubmed Data : J Biomed Nanotechnol. 2021 Nov 1 ;17(11):2247-2258. PMID: 34906285
Article Published Date : Oct 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Radiosensitizer
[+]

Molecular docking analysis of lupeol with different cancer targets.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bioinformation. 2022 ;18(3):134-140. Epub 2022 Mar 31. PMID: 36518133
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative
[+]

Potential targeting of Hep3B liver cancer cells by lupeol isolated from Avicennia marina.Aug 31, 2021

Pubmed Data : Arch Pharm (Weinheim). 2021 Sep ;354(9):e2100120. Epub 2021 Jun 4. PMID: 34085721
Article Published Date : Aug 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Role of lupeol in chemosensitizing therapy-resistant prostate cancer cells.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : In Silico Pharmacol. 2022 ;10(1):16. Epub 2022 Sep 4. PMID: 36072559
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Prostate Cancer
Pharmacological Actions : Chemosensitizer
[+]

Suppression of EGFR/STAT3 activity by lupeol contributes to the induction of the apoptosis of human non‑small cell lung cancer cells.Jun 30, 2019

Pubmed Data : Int J Oncol. 2019 Jul ;55(1):320-330. Epub 2019 May 7. PMID: 31115519
Article Published Date : Jun 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Non-Small-Cell Lung Carcinoma
Pharmacological Actions : Apoptotic, STAT3 Inhibitor
[+]

These findings suggest that lupeol has therapeutic potential for accelerating wound healing.Oct 29, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Oct 30 ;23(11). Epub 2018 Oct 30. PMID: 30380745
Article Published Date : Oct 29, 2018
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Wound Healing
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

This review suggests that lupeol might be a valuable anti-inflammatory, anti-diabetic, hepatoprotective and anticancer treatment.Dec 31, 2015

Pubmed Data : Adv Exp Med Biol. 2016 ;929:145-175. PMID: 27771924
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Lupeol
Diseases : Cancers: All, Hyperglycemia, Inflammation, Liver Damage
Pharmacological Actions : Alpha-amylase inhibitor, Alpha-glucosidase inhibitor , Anti-Inflammatory Agents, Cardioprotective, Hepatoprotective, Hypoglycemic Agents, NF-kappaB Inhibitor
[+]

This study further confirms the traditional role of Ficus benjamina plant in the treatment of malaria which may be attributed to ursolic acid and lupeol.Jan 01, 2019

Pubmed Data : Nat Prod Res. 2019 Jan 2:1-4. Epub 2019 Jan 2. PMID: 30600705
Article Published Date : Jan 01, 2019
Study Type : In Vitro Study
Additional Links
Substances : Fig, Lupeol, Ursolic Acid
Diseases : Malaria
Pharmacological Actions : Antimalarials
[+]

This study highlights the potential of both stigmasterol and lupeol as new promising anti-MRSA agents.Dec 08, 2016

Pubmed Data : J Glob Antimicrob Resist. 2016 Dec 9 ;8:48-54. Epub 2016 Dec 9. PMID: 27992774
Article Published Date : Dec 08, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lupeol, Stigmasterol
Diseases : Methicillin-resistant Staphylococcus aureus
Pharmacological Actions : Anti-Bacterial Agents

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