Lycopene

Name	AC	CK
Prostate Cancer	21	133
Oxidative Stress	45	102
Cardiovascular Diseases	15	73
Liver Cancer	14	56
Inflammation	16	44
Diabetes Mellitus: Type 2	8	41
Fibrosis	3	40
Breast Cancer	11	39
Hypertension	4	32
Alzheimer's Disease	15	31
All-Cause Mortality	3	30
Infertility: Male	6	27
Obesity	10	27
Ultraviolet Radiation Induced Damage	2	23
Prostatic Hyperplasia: Benign	3	22
Metabolic Syndrome X	3	21
Periodontal Diseases	3	21
Cancer Mortality	2	20
Cardiac Mortality	2	20
Cardiovascular Disease: Prevention	1	20
Carotenoid Deficiency	2	20
Gastric Cancer: Prevention	1	20
Nonalcoholic fatty liver disease (NAFLD)	11	19
Osteoporosis	6	19
Cognitive Decline/Dysfunction	5	18
Lipopolysaccharide-Induced Toxicity	10	18
Phthalate Toxicity	10	18
Testicular Injury: Chemical/Metal Induced	10	18
Aging	4	15
Brain: Oxidative Stress	5	15
Cancer Metastasis	4	14
Chemotherapy and Radiation Toxicity	3	14
High Fat Diet	7	14
Osteoarthritis	4	14
Human Papillomavirus (HPV)	2	12
Prostate Cancer: Prevention	2	12
Uterine Cervical Neoplasms	2	12
Bisphenol Toxicity	6	11
Cancers: All	11	11
Pancreatic Cancer	2	11
Aging: Brain	1	10
Asthma	1	10
Asthma: Bronchial	1	10
Brain Inflammation	6	10
Breast Cancer: Prevention	1	10
Chemically-Induced Liver Damage	5	10
Cholesterol: Oxidation	1	10
Endometrial Cancer	1	10
Endothelial Damage	1	10
Erectile Dysfunction	1	10
Gingivitis	1	10
Heart Failure	1	10
Ischemia	5	10
Kidney Cancer	1	10
Liver Disease	1	10
Memory Disorders	5	10
Menopausal Syndrome	1	10
Oral Submucous Fibrosis	1	10
Overweight	1	10
Pre-Eclampsia	1	10
Prostate: PSA Doubling	1	10
Prostatitis: Bacterial	1	10
Vitamin A Deficiency	1	10
Vitamin E Deficiency	1	10
Kidney Damage: Chemically-Induced	4	8
Lipid Peroxidation	4	8
Liver Damage	4	8
Chemotherapy-Induced Toxicity: Cisplatin	4	7
Diabetic Complications	4	7
Hydrogen Peroxide Induced Toxicity	6	7
Hyperlipidemia	4	7
Liver Cirrhosis	4	7
Lung Cancer	5	7
Pesticide Toxicity	4	7
Atherosclerosis	4	6
Chemotherapy-Induced Toxicity: Gentamicin	3	6
Colitis	3	6
Hypercholesterolemia	3	6
Insulin Resistance	4	6
Kidney Damage	3	6
Liver Damage: Drug-Induced	3	6
Metabolic Diseases	3	6
Myocardial Ischemia	3	6
Neurodegenerative Diseases	6	6
Parkinson's Disease	4	6
Prostatitis: Chronic	3	6
Colorectal Cancer	4	5
Diabetes: Oxidative Stress	3	5
Fluoride Toxicity	3	5
Gastric Cancer	5	5
High Cholesterol	1	5
Acetaminophen (Tylenol) Toxicity	2	4
Aflatoxicosis	2	4
Dementia	2	4
Drug-Induced Toxicity: Methotrexate	2	4
Food Allergies	2	4
Liver Damage: Aflatoxin-Induced	2	4
Liver Fibrosis	3	4
Liver Injury: Ischemia/reperfusion	3	4
Lung Injury: Acute	2	4
Lung Injury: Smoke-Induced	2	4
Myocardial Infarction	2	4
Skin Cancer	2	4
Spinal Cord Injuries	2	4
Brain Ischemia	2	3
Cancers: Multi-Drug Resistant	2	3
Cerebral Ischemia	2	3
Colon Cancer	3	3
DNA damage	3	3
Diabetes Mellitus: Type 1	2	3
Diabetic Nephropathy	2	3
Drug Toxicity: Methotrexate	2	3
Lung Cancer: Metastatic	2	3
Malaria	2	3
Mitochondrial Dysfunction	2	3
Ulcerative Colitis	2	3
Advanced Glycation End products (AGE)	1	2
Air Pollution Linked Toxicity	1	2
Alcoholic Liver Disease	2	2
Allergic Rhinitis	1	2
Aluminum Toxicity	1	2
Anemia	1	2
Arthritis: Rheumatoid	1	2
Atopic Dermatitis	1	2
Benzo[a]pyrene-induced Toxicity	1	2
Bladder Outlet Obstruction	1	2
C-Reactive Protein	1	2
Cardiac Hypertrophy	1	2
Cataract	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Chemotherapy-Induced Toxicity: Kidney	1	2
Chemotherapy-Induced Toxicity: Peripheral Neuropathy	1	2
Cholestasis	1	2
Chronic Obstructive Pulmonary Disease	1	2
Chronic Pelvic Pain Syndrome	1	2
Diabetic Neuropathy	1	2
Dysbiosis	1	2
Dyslipidemias	1	2
Epididymitis	1	2
Epilepsy	1	2
Escherichia coli Infections	1	2
Fatty Liver	1	2
Female Reproductive Development Abnormalities	1	2
Fluorosis	1	2
Fulminant Hepatic Failure	1	2
Glaucoma	1	2
Head and Neck Cancer	1	2
Hypoxia	1	2
Inflammatory Bowel Diseases	1	2
Leiomyoma	1	2
Lymphoma	1	2
Male Reproductive Development Abnormalities	1	2
Mycotoxin Toxicity	1	2
Nephropathy	1	2
Oral Cancer	2	2
Pancreatitis	2	2
Post-Traumatic Stress Disorders (PTSD)	1	2
Prenatal Chemical Exposures	1	2
Prostatic Hyperplasia	1	2
Pulmonary Emphysema	1	2
Radiation	1	2
Radiation Induced Illness: Mucositis	1	2
Seizures	1	2
Sepsis	1	2
Smoking	1	2
Squamous cell carcinoma	2	2
Staphylococcus aureus infection	1	2
Steroid-Induced Toxicity	1	2
Stress	1	2
Tobacco Toxicity	1	2
Ulcers	1	2
Uveitis	1	2
Alcohol Toxicity	1	1
Allergies	1	1
Autism Spectrum Disorders	1	1
Cancer Stem Cells	1	1
Candida Infection	1	1
Central Nervous System Diseases	1	1
Cervical Cancer	1	1
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	1
Degenerative Disk Disease	1	1
Encephalopathy	1	1
Esophageal Cancer	1	1
Fructose-Induced Toxicity	1	1
Glioblastoma	1	1
Heavy Metal Toxicity	1	1
Helicobacter Pylori Infection	1	1
Hepatoma	1	1
High Fructose Diet	1	1
Leukoplakia	1	1
Liver Cancer: Prevention	1	1
Lung Cancer: Prevention	1	1
Melanoma	1	1
Ovarian Cancer	1	1
Photodermatosis	1	1
Psoriasis	1	1
Radiation Induced Illness	1	1
Respiratory Diseases	1	1
Rhinovirus Infection	1	1
Stroke	1	1
Sunburn	1	1
Tertiary butyl hydroperoxide toxicity	1	1

Name	AC	CK
Antioxidants	151	378
Anti-Inflammatory Agents	93	184
Chemopreventive	26	160
Neuroprotective Agents	43	88
Interleukin-6 Downregulation	23	75
Antiproliferative	32	72
Cardioprotective	27	70
Hepatoprotective	33	68
Anticarcinogenic Agents	23	66
Tumor Necrosis Factor (TNF) Alpha Inhibitor	27	55
Anti-Apoptotic	26	45
Anti-Fibrotic	5	43
Antihypertensive Agents	4	42
Hypoglycemic Agents	3	33
Nrf2 activation	22	33
Cell cycle arrest	11	30
Anticholesteremic Agents	4	29
Apoptotic	19	29
Interleukin-1 beta downregulation	16	29
Hypolipidemic	11	27
Renoprotective	13	25
Photoprotective	2	23
NF-kappaB Inhibitor	13	22
Radioprotective	7	20
Anti-metastatic	6	17
Chemoprotective Agents	9	16
Fertility Agents: Male	4	15
Malondialdehyde Down-regulation	8	15
Gastrointestinal Agents	3	14
Chemotherapeutic	3	13
Heme oxygenase-1 up-regulation	9	13
Superoxide Dismutase Up-regulation	7	13
Anti-Bacterial Agents	2	12
Antineoplastic Agents	3	12
Matrix metalloproteinase-2 (MMP-2) inhibitor	6	11
Cyclooxygenase 2 Inhibitors	6	9
Osteoprotective	5	9
Chemosensitizer	5	7
Immunomodulatory	4	6
Anti-Allergic Agents	2	4
Cytoprotective	2	4
Gastroprotective	2	4
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	4
Interleukin-2 Downregulation	2	4
Angiogenesis Inhibitors	2	3
Interleukin-8 downregulation	2	3
Anti-Glycation Agents	1	2
Anti-Ulcer Agents	1	2
Antimalarials	1	2
Bcl-2 protein down-regulation	2	2
Catalase Up-Regulation	1	2
Insulin Sensitizers	1	2
Interferon Gamma Reducer	1	2
Interleukin-10 downregulation	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	2
MicroRNA modulator	1	2
Neurogenesis	1	2
Pancreato Protective Agents	2	2
SIRT1 Activator	2	2
STAT3 Inhibitor	1	2
Vascular Endothelial Growth Factor A Inhibitor	1	2
Vascular Endothelial Growth Factor Inhibitors	1	2
anti-inflammatory	1	2
Anti-Proliferative	1	1
Autophagy Inhibitors	1	1
Autophagy Up-regulation	1	1
Chelating Agents	1	1
Chondroprotective	1	1
Cyclin D1 Down-Regulation	1	1
Cytotoxic	1	1
Genoprotective	1	1
Immunostimulatory	1	1
Interleukin-1 alpha downregulation	1	1
Matrix Metalloproteinase-7 (MMP-7) Inhibitor	1	1
P-glycoprotein Inhibitors	1	1
P21 Activation	1	1
Phase II Detoxification Enzyme Inducer	1	1
Tumor Suppressor Protein p53 Upregulation	1	1
Wnt/β-catenin pathway down-regulation	1	1

[+]

Effect of supplemental antioxidant-based therapy on the oxidative stress level in COVID-19 patients.Feb 28, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Eur J Nutr. 2012 Mar ;51(2):231-9. Epub 2011 Jun 7. PMID: 21647668

Article Published Date : Feb 29, 2012

Study Type : Human Study

Additional Links

Substances : beta-Carotene, Carotenoids, Lycopene, Soup

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Bioavailability

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Higher concentrations of trans- and cis-lycopene may reduce the time to clearance of an oncogenic HPV infection.May 01, 2003

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Pubmed Data : Cancer Causes Control. 2003 May;14(4):319-26. PMID: 12846362

Article Published Date : May 01, 2003

Study Type : Human Study

Additional Links

Substances : Carotenoids, Lycopene

Diseases : Human Papillomavirus (HPV), Uterine Cervical Neoplasms

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Higher intake of lycopene, beta-carotene and beta-cryptoxanthin is associated to a lower risk of breast cancer among Chinese women.Jan 01, 2007

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Pubmed Data : Asia Pac J Clin Nutr. 2007;16 Suppl 1:437-42. PMID: 17392146

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Pubmed Data : Br J Nutr. 2013 Jun ;109(11):2031-5. Epub 2012 Oct 15. PMID: 23069270

Pubmed Data : J Nutr. 2008 Jan;138(1):49-53. PMID: 18156403

Article Published Date : Jan 01, 2008

Study Type : Human Study

Additional Links

Substances : Lycopene

Diseases : Prostatic Hyperplasia: Benign

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Lycopene is a promising treatment modality as an adjunct to full mouth SRP of the oral cavity in patients with moderate periodontal disease.Oct 31, 2013

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Pubmed Data : J Contemp Dent Pract. 2013 Nov-Dec;14(6):1054-9. Epub 2013 Nov 1. PMID: 24858750

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Pubmed Data : Asia Pac J Clin Nutr. 2017 Jan ;26(1):65-71. PMID: 28049263

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Substances : Lycopene, Tomato

Diseases : Infertility: Male

Additional Keywords : Infertility: Male, lycopene, Tomato

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Renal cell carcinoma risk associated with lower intake of micronutrients.Dec 31, 2017

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Pubmed Data : Cancer Med. 2018 08 ;7(8):4087-4097. Epub 2018 Jul 2. PMID: 29968964

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Substances : Alpha-Carotene, beta-Carotene, Cryptoxanthin, Folate, Lutein, Lycopene, Selenium, Thiamine (B-1) , Vitamin A, Vitamin C, Vitamin E, Zeaxanthin

Diseases : Kidney Cancer

Pharmacological Actions : Chemopreventive

Additional Keywords : Risk Reduction

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Results of this study suggest that the carotenoids beta-cryptoxanthin, lycopene, and lutein/zeaxanthin may protect against breast cancer. Dec 31, 1997

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Pubmed Data : Cancer Causes Control. 1998 Jan ;9(1):89-97. PMID: 9486468

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Pubmed Data : Ann Med. 2021 Dec ;53(1):1058-1064. PMID: 34180336

Article Published Date : Nov 30, 2021

Study Type : Human Study

Additional Links

Substances : Lycopene

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Antioxidants, Hypoglycemic Agents

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The combination of serenoa repens, selenium, lycopene and bromelain are beneficial in patients with chronic bacterial prostatitis.Oct 04, 2016

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Pubmed Data : Am J Clin Nutr. 2016 Jan 27. Epub 2016 Jan 27. PMID: 26817504

A variety of carotenoids induce reduce resistance to chemotherapy in multidrug resistant lymphoma and human breast cancer cell lines. Mar 01, 2004

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Pubmed Data : In Vivo. 2004 Mar-Apr;18(2):237-44. PMID: 15113052

Article Published Date : Mar 01, 2004

Study Type : Animal Study

Additional Links

Substances : Carotenoids, Lycopene, Paprika, Zeaxanthin

Diseases : Breast Cancer, Cancers: Multi-Drug Resistant, Lymphoma

Pharmacological Actions : Apoptotic, Chemosensitizer

Additional Keywords : Drug-Plant-Vitamin Synergies

[+]

Algal lycopene showed very significant antioxidant and anti-inflammatory effect in high-cholesterol fed rats.Jan 31, 2014

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Pubmed Data : Inflammopharmacology. 2014 Feb ;22(1):45-54. Epub 2013 Jul 26. PMID: 23887896

Article Published Date : Jan 31, 2014

Study Type : Animal Study

Additional Links

Substances : Chlorella (Algae), Lycopene

Diseases : C-Reactive Protein, Hypercholesterolemia, Hyperlipidemia, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Anticholesteremic Agents, Antioxidants, Catalase Up-Regulation, Superoxide Dismutase Up-regulation

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Combination therapy of rosmarinic acid and lycopene shows better protective effects than the corresponding monotherapy.Nov 23, 2016

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Pubmed Data : Anat Rec (Hoboken). 2016 Nov 24. Epub 2016 Nov 24. PMID: 27884046

Article Published Date : Nov 23, 2016

Study Type : Animal Study

Additional Links

Substances : Lycopene, Rosmarinic acid

Diseases : Chemotherapy-Induced Toxicity: Gentamicin

Pharmacological Actions : Chemoprotective Agents, Renoprotective

Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Gentamicin, lycopene, Renoprotective, Rosmarinic acid

[+]

Dietary tomato components reduced testosterone regulated genes associated with early prostate carcinogenesis.Nov 30, 2014

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Pubmed Data : Cancer Prev Res (Phila). 2014 Dec ;7(12):1228-39. Epub 2014 Oct 14. PMID: 25315431

Lycopene alleviates lipopolysaccharide-induced testicular injury.Feb 27, 2023

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Pubmed Data : Transl Androl Urol. 2023 Feb 28 ;12(2):271-285. Epub 2023 Feb 15. PMID: 36915878

Article Published Date : Feb 27, 2023

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Lipopolysaccharide-Induced Toxicity, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic

[+]

Lycopene alleviates multiple-mycotoxin-induced toxicity.Nov 13, 2022

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Pubmed Data : Food Funct. 2022 Nov 14 ;13(22):11532-11542. Epub 2022 Nov 14. PMID: 36318035

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Pubmed Data : Ecotoxicol Environ Saf. 2023 May ;256:114846. Epub 2023 Apr 3. PMID: 37018856

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Pubmed Data : Environ Toxicol Pharmacol. 2019 Jul ;69:44-50. Epub 2019 Mar 18. PMID: 30953933

Article Published Date : Jun 30, 2019

Study Type : Animal Study

Additional Links

Substances : Lycopene, Resveratrol

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants

Problem Substances : Nanoparticles, Zinc Oxide

[+]

Lycopene and tomato powder supplementation similarly inhibit high-fat diet induced obesity, inflammatory response, and associated metabolic disorders.Mar 06, 2017

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Pubmed Data : Mol Nutr Food Res. 2017 Mar 7. Epub 2017 Mar 7. PMID: 28267248

Pubmed Data : Microbes Infect. 2021 Jul 2:104853. Epub 2021 Jul 2. PMID: 34224857

Article Published Date : Jul 01, 2021

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Staphylococcus aureus infection

Pharmacological Actions : Anti-Inflammatory Agents

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Lycopene attenuates western-diet-induced cognitive deficits via improving glycolipid metabolism dysfunction and inflammatory responses in gut-liver-brain axis.Dec 31, 2018

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Pubmed Data : Int J Obes (Lond). 2019 09 ;43(9):1735-1746. Epub 2018 Dec 11. PMID: 30538283

Article Published Date : Dec 31, 2018

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Pubmed Data : Zhonghua Nan Ke Xue. 2021 Feb ;27(2):99-105. PMID: 34914324

Article Published Date : Jan 31, 2021

Study Type : Animal Study

Additional Links

Substances : Curcumin, Lycopene, Quercetin

Diseases : Prostatitis: Chronic

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-2 Downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Lycopene corrects metabolic syndrome and liver injury induced by high fat diet.Jul 05, 2021

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Pubmed Data : Biomed Pharmacother. 2021 Jul 6 ;141:111831. Epub 2021 Jul 6. PMID: 34237596

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Pubmed Data : Braz Dent J. 2023 ;34(3):50-56. PMID: 37466525

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Pubmed Data : World J Gastroenterol. 2016 Dec 14 ;22(46):10180-10188. PMID: 28028366

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Pubmed Data : Chem Biol Interact. 2017 Feb 1 ;263:7-17. Epub 2016 Dec 15. PMID: 27989599

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Pubmed Data : Parasitol Int. 2024 Feb 28 ;101:102873. Epub 2024 Feb 28. PMID: 38428566

Article Published Date : Feb 27, 2024

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Malaria

Pharmacological Actions : Antimalarials

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Lycopene possesses significant cardioprotective potential and may serve as an adjunct in treatment and prophylaxis of myocardial infarction.Apr 30, 2013

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Pubmed Data : Hum Exp Toxicol. 2013 May ;32(5):492-503. Epub 2012 Oct 11. PMID: 23060410

Article Published Date : Apr 30, 2013

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Lipid Peroxidation, Myocardial Infarction

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective

Additional Keywords : Drug: Isoproterenol, Risk Reduction

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Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in mice.Jan 31, 2017

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Pubmed Data : Bioorg Med Chem. 2017 Feb 1 ;25(3):1057-1065. Epub 2016 Dec 18. PMID: 28031152

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Pubmed Data : J Agric Food Chem. 2023 Oct 23. Epub 2023 Oct 23. PMID: 37871231

Article Published Date : Oct 22, 2023

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Phthalate Toxicity

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation

Problem Substances : Phthalates

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Pharmacological Actions : Antioxidants

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Lycopene protects myocardial ischemia injury through anti-apoptosis and anti-oxidative stress.Mar 31, 2019

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Pubmed Data : Eur Rev Med Pharmacol Sci. 2019 Apr ;23(7):3096-3104. PMID: 31002159

Article Published Date : Mar 31, 2019

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Myocardial Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Lycopene provides protection against development of diabetic nephropathy.Oct 09, 2015

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Pubmed Data : Biofactors. 2015 Oct 10. Epub 2015 Oct 10. PMID: 26453295

Article Published Date : Oct 09, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Lycopene

Diseases : Advanced Glycation End products (AGE), Diabetic Nephropathy

Pharmacological Actions : Anti-Glycation Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor, NF-kappaB Inhibitor

[+]

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Protective effects of lycopene on mitochondrial oxidative injury and dysfunction in the liver of aflatoxin B 1-exposed broilers.Aug 18, 2021

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Pubmed Data : Poult Sci. 2021 Aug 19 ;100(11):101441. Epub 2021 Aug 19. PMID: 34547623

Article Published Date : Aug 18, 2021

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Liver Damage: Aflatoxin-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Aflatoxin

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Protective role of lycopene against metabolic disorders induced by chronic bisphenol A exposure.Jan 07, 2020

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Pubmed Data : Environ Sci Pollut Res Int. 2020 Jan 8. Epub 2020 Jan 8. PMID: 31916151

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Pubmed Data : Libyan J Med. 2021 Dec ;16(1):1943924. PMID: 34151749

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Pubmed Data : Urology. 2011 Jan;77(1):248.e9-16. Epub 2010 Dec 15. PMID: 21109292

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Substances : Carotenoids, Lycopene, Selenium

Diseases : Bladder Outlet Obstruction, Inflammation, Prostatic Hyperplasia: Benign

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor

[+]

Standardized extracts of lycopene and hesperidin together can be cheap and very effective herbal alternative for the treatment of ulcers.Mar 31, 2015

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Pubmed Data : J Intercult Ethnopharmacol. 2015 Apr-Jun;4(2):143-6. Epub 2015 Mar 16. PMID: 26401402

Article Published Date : Mar 31, 2015

Study Type : Animal Study

Additional Links

Substances : Hesperidin, Lycopene

Diseases : Ulcers

Pharmacological Actions : Anti-Ulcer Agents, Antioxidants

Additional Keywords : Natural Substance Synergy

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Supplementation of diet with lycopene and melatonin provided antioxidant defense with strong protective activity against cyclophosphamide induced cytotoxicity.Jun 30, 2014

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Pubmed Data : Toxicol Ind Health. 2014 Jul ;30(6):570-5. Epub 2012 Sep 28. PMID: 23024110

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Pubmed Data : Sci Rep. 2021 Jul 7 ;11(1):13979. Epub 2021 Jul 7. PMID: 34234176

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Pubmed Data : Foods. 2021 Aug 15 ;10(8). Epub 2021 Aug 15. PMID: 34441662

Article Published Date : Aug 14, 2021

Study Type : Animal Study

Additional Links

Substances : Black Currant, Gastrodin, Lycopene, Vitamin D

Diseases : Glaucoma

Pharmacological Actions : Anti-Apoptotic, Antioxidants

[+]

This study demonstrates that dietary supplementation with lycopene has a multidimensional role in preventing liver cancer development.Oct 17, 2016

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A lycopene-rich extract from red guava was able to induce cytostatic and cytotoxic effects on breast cancer cells.Feb 28, 2018

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Pubmed Data : Food Res Int. 2018 Mar ;105:184-196. Epub 2017 Oct 27. PMID: 29433206

Article Published Date : Feb 28, 2018

Study Type : In Vitro Study

Additional Links

Substances : Guava, Lycopene

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cytotoxic

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Biomol Struct Dyn. 2021 Jun 17:1-8. Epub 2021 Jun 17. PMID: 34138692

Article Published Date : Jun 16, 2021

Study Type : In Vitro Study

Additional Links

Substances : Lycopene, Thymoquinone

Diseases : Cancers: All

Pharmacological Actions : Chemotherapeutic

[+]

Investigating into anti-cancer potential of lycopene: molecular targets.May 31, 2021

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Pubmed Data : Nutr Res Pract. 2017 Apr ;11(2):90-96. Epub 2017 Feb 15. PMID: 28386381

Article Published Date : Mar 31, 2017

Study Type : In Vitro Study

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Substances : Lycopene

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Lycopene and β-carotene may act as potent anti-proliferative agents in ESCC cells.Apr 30, 2018

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Pubmed Data : Oncol Lett. 2018 May ;15(5):6727-6732. Epub 2018 Mar 5. PMID: 29731858

Article Published Date : Apr 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : beta-Carotene, Lycopene

Diseases : Esophageal Cancer

Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, P21 Activation

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Lycopene consumption may be associated with favourable alterations to the components of metabolic syndrome.Dec 31, 2018

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Pubmed Data : Adv Nutr. 2019 01 1 ;10(1):19-29. PMID: 30475939

Article Published Date : Dec 31, 2018

Study Type : Review

Additional Links

Substances : Lycopene

Diseases : Metabolic Syndrome X

Pharmacological Actions : Antioxidants, Hypolipidemic

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View the Evidence: 372 Abstracts with Lycopene Research

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The effect of tomato and lycopene on clinical characteristics and molecular markers of UV-induced skin deterioration.Jan 05, 2023

This systematic review and meta-analyses suggested that lycopene intake exerted an FBG-decreasing effect.Dec 26, 2022

Administration of lycopene appears to inhibit the initiation and progression of cancer in animal models of hepatocellular carcinoma.Dec 31, 2019

Consumption of large amounts of tomato products may be associated with a reduced risk of gastric cancer.Mar 31, 2013

Efficacy of lycopene in the treatment of oral submucous fibrosis.Jan 11, 2020

Higher lycopene exposure is inversely associated with a lower risk of CVD.Mar 19, 2017

Increased dietary and circulating lycopene are associated with reduced prostate cancer risk.Apr 24, 2017

Lycopene inhibits liver cancer cell growth.Jan 01, 2005

This dose-response meta-analysis demonstrated that higher lycopene consumption was linearly associated with a reduced risk of PC.Jul 31, 2015

Tomato extract significantly decreased SBP compared to placebo in a mixed population of healthy volunteers and hypertensive patients.Jul 14, 2021

Tomato products and lycopene supplementation have positive effects on blood lipids, blood pressure and endothelial function.Jan 12, 2017

A combination of soy, isoflavones, lycopene, silymarin and antoxidants significantly increases PSA doubling time in men with prostate cancer. Dec 01, 2005

A formula containing calcium, vitamin D3, lycopene , astaxantin and citrus bioflavonoids reducing climacteric symptoms in menopausal women. Jun 01, 2010

A high consumption of tomato and lycopene is associated with a lower risk of cancer mortality.Feb 26, 2020

A higher intake of tomatoes and lycopene is inversely related to the risk of CVD mortality.Dec 29, 2022

A phase II study of docetaxel plus lycopene in metastatic castrate resistant prostate cancer.Oct 31, 2021

Carotenoids such as lycopene have a protective effect on bone health.Jun 01, 2009

Consumption of canned and cooked tomatoes may reduce the risk of prostate cancer.Feb 24, 2020

Consumption of watermelon juice increases plasma concentrations of lycopene and beta-carotene in humans.Apr 01, 2003

Curcumin and lycopene treatment led to significant improvements in patients suffering from oral submucous fibrosis.Jul 29, 2018

Dietary calcium impairs tomato lycopene bioavailability in healthy humans.Nov 30, 2016

Dietary carotenoid intake and risk of developing preeclampsia.May 20, 2022

Dietary intake of lycopene is associated with reduced pancreatic cancer risk.Mar 01, 2005

Dietary intake of tomato and lycopene and risk of all-cause and cause-specific mortality.Dec 31, 2020

Effect of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease.Aug 31, 2018

Effect of supplemental antioxidant-based therapy on the oxidative stress level in COVID-19 patients.Feb 28, 2023

Effects of lycopene-enriched, organic, extra virgin olive oil on benign prostatic hyperplasia.Jan 07, 2021

Evaluation of efficacy of curcumin along with lycopene and piperine in the management of oral submucous fibrosis.Jun 30, 2019

Fruit and vegetable soups contributed to increasing the concentration of each carotenoid by more than 100% after 3 and 4 weeks of consumption. Feb 29, 2012

Higher concentrations of trans- and cis-lycopene may reduce the time to clearance of an oncogenic HPV infection.May 01, 2003

Higher intake of lycopene, beta-carotene and beta-cryptoxanthin is associated to a lower risk of breast cancer among Chinese women.Jan 01, 2007

Higher serum lycopene concentration has a significant association with the reduced risk of mortality among individuals with metabolic syndrome.Apr 30, 2016

Improvement of executive function after short-term administration of an antioxidants mix.Dec 26, 2020

Increasing tomato intake may provide a useful approach for reducing the risk of inflammatory diseases such as CVD and diabetes, which are associated with obesity.May 31, 2013

Insufficient lycopene intake is associated with high risk of prostate cancer.Dec 31, 2020

Interventions with tomato-products alone or in combination with selenium and n-3 fatty acids lower PSA in patients with non-metastatic prostate cancer.Jun 29, 2016

Lower dietary lycopene intake is positively associated with an increased risk of erectile dysfunction in US men.Apr 09, 2023

Lower serum levels of alpha tocopherol and lycopene is associated with higher pain and physical disability in subjects with primary knee osteoarthritis.Jan 22, 2020

Lycopene and soy isoflavones have activity in prostate cancer patients with PSA relapse disease and may delay progression of both hormone-refractory and hormone-sensitive prostate cancer.Jul 01, 2009

Lycopene contributes to the inhibition of LDL oxidation. Sep 01, 2000

Lycopene inhibits disease progression in patients with benign prostate hyperplasia. Jan 01, 2008

Lycopene is a promising treatment modality as an adjunct to full mouth SRP of the oral cavity in patients with moderate periodontal disease.Oct 31, 2013

Lycopene may positively modify clinical asthma outcomes. Jan 01, 2008

Lycopene supplement can improve sperm parameters and oxidative stress biomarkers in oligozoospermia infertile men.Aug 29, 2019

Lycopene with green tea extract may prove to be a promising adjunctive prophylactic and therapeutic modality in the treatment of gingivitis patients.Dec 31, 2018

Plasma levels of beta-carotene and lycopene are inversely associated with the risk of endometrial cancer in Korean women.Jan 01, 2009

Protective role of lycopene in subjects with liver disease.Feb 17, 2024

Regular consumption of tomato juice seems to improve sperm motility in infertile patients.Dec 31, 2016

Renal cell carcinoma risk associated with lower intake of micronutrients.Dec 31, 2017

Results of this study suggest that the carotenoids beta-cryptoxanthin, lycopene, and lutein/zeaxanthin may protect against breast cancer. Dec 31, 1997

Serum lycopene, lutein and zeaxanthin, and the risk of Alzheimer's disease mortality in older adults.Dec 31, 2013

Supplementing with lycopene can enhance endothelial function and reduce the TG levels in ischemic ischemic heart failure patients.Dec 31, 2021

T2DM patients with a higher lycopene intake showed a greater peripheral antioxidant capacity and better glycaemic control.Nov 30, 2021

The combination of serenoa repens, selenium, lycopene and bromelain are beneficial in patients with chronic bacterial prostatitis.Oct 04, 2016

The effects of lycopene on modulating oxidative stress and liver enzymes levels in metabolic syndrome patients.Dec 30, 2023

The results suggest a protective role of α-carotene, β-carotene, lycopene , lutein and zeaxanthin in breast cancer risk.Oct 19, 2015

These data highlighted the favourable effect of tomato and lycopene on total and cause-specific mortality as well as to cardio-metabolic risk factors.Aug 21, 2019

This is the first study which reports the prebiotic potential of lycopene and dark chocolate.Dec 31, 2018

Tomato juice consumption could improve breast skin adverse effects of radiotherapy in breast cancer patients.Aug 31, 2020

Tomato sauce consumption may play a role in reducing TMPRSS2:ERG-positive prostate cancer. Jan 26, 2016

Tomato sauce supplementation reduces prostate cancer growth in men.Nov 01, 2002

Total carotenoids showed significant reductive risk of hypertension at 100 μg/kg per day and over.Jul 25, 2019

Treatment with lycopene led to improvement in the symptoms of oral submucous fibrosis in the present study.Jul 10, 2020

Vegetables and fruits rich in lycopene and other carotenoids may be protective against prostate cancer.Mar 01, 2005

Watermelon juice is an effective means of increasing serum lycopene in older adult women.May 31, 2019

Women with high plasma carotenoids were at reduced breast cancer risk particularly for more aggressive and ultimately fatal disease.Apr 14, 2015

This study provides the first evidence that lycopene inhibits cholesterol absorption in the intestinal cells.Aug 11, 2015

Facilitating pro-survival mitophagy for alleviating Parkinson's disease via sequence-targeted lycopene nanodots.Sep 25, 2023

Lycopene prevents bone loss in ovariectomized rats and increases the number of osteocytes and osteoblasts.Apr 19, 2022

"Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats."Apr 15, 2010

A combination of lycopene and vitamin E acted in a synergistic fashion to bring significant effects against oxidative stress in tauopathies.Dec 31, 2016

A variety of carotenoids induce reduce resistance to chemotherapy in multidrug resistant lymphoma and human breast cancer cell lines. Mar 01, 2004

Lycopene

View the Evidence:
372 Abstracts with Lycopene Research