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21 Diseases Researched for Magnolol
NameACCKFocus
Gallbladder Cancer15Locked
Carcinoma: Non-Small-Cell Lung23Locked
Cerebral Ischemia13Locked
Bladder Cancer12Locked
Cachexia: Cancer12Locked
Cachexia: Chemotherapy Induced12Locked
Colitis12Locked
Lupus Nephritis12Locked
Pulmonary Fibrosis: Bleomycin-Induced12Locked
Staphylococcus aureus: Methicillin-resistant (MRSA)22Locked
Stroke: Attenuation/Recovery 12Locked
Alzheimer's Disease11Locked
Atherosclerosis11Locked
Candida Infection 11Locked
Cholangiocarcinoma11Locked
Dental Caries11Locked
Glioblastoma11Locked
Human Gastric Adenocarcinoma 11Locked
Parkinson's Disease11Locked
Promyelocytic leukemia 11Locked
Streptococcus Infections11Locked
23 Pharmacological Actions Researched for Magnolol
NameACCKFocus
Anti-Inflammatory Agents613Locked
Apoptotic611Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor510Locked
Cell cycle arrest49Locked
Antiproliferative 67Locked
Interleukin-1 beta downregulation37Locked
Tumor Suppressor Protein p53 Upregulation27Locked
NF-kappaB Inhibitor46Locked
Cyclin D1 Down-Regulation15Locked
Neuroprotective Agents35Locked
P21 Activation15Locked
Antimicrobial33Locked
Anti-Apoptotic12Locked
Anti-Bacterial Agents22Locked
Interleukin-6 Downregulation12Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor22Locked
Anti-atherogenic11Locked
Anti-metastatic11Locked
Autophagy Up-regulation11Locked
Bcl-2 protein down-regulation11Locked
Histone deacetylase inhibitor11Locked
Matrix Metalloproteinase-7 (MMP-7) Inhibitor11Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor11Locked

View the Evidence:
73 Abstracts with Magnolol Research

[+]

Magnolol induced cell cycle arrest and promoted apoptosis in gallbladder carcinoma cells by regulating the p53 signaling pathway.Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Sci. 2015 Oct ;106(10):1341-50. PMID: 26250568
Article Published Date : Sep 30, 2015
Study Type : Human In Vitro
Additional Links
Substances : Magnolol
Diseases : Gallbladder Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

Antidepressant effects of magnolol in a mouse model of depression.Jun 30, 2018

Pubmed Data : Steroids. 2018 Jul ;135:73-78. Epub 2018 Mar 17. PMID: 29555480
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Brain-derived neurotrophic factor modulator
[+]

Apoptosis induction and ERK/NF-κB inactivation are associated with magnolol-inhibited tumor progression in hepatocellular carcinoma.Nov 11, 2019

Pubmed Data : Environ Toxicol. 2019 Nov 12. Epub 2019 Nov 12. PMID: 31714653
Article Published Date : Nov 11, 2019
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Cyclin D1 Down-Regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

CYP3A excipient-based microemulsion prolongs the effect of magnolol on ischemia stroke rats.Aug 04, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceutics. 2020 Aug 5 ;12(8). Epub 2020 Aug 5. PMID: 32764430
Article Published Date : Aug 04, 2020
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Stroke: Ischemic
Pharmacological Actions : Neuroprotective Agents
[+]

Magnolol administration prevented trimethyltin induced hippocampal neurodegeneration and glial activation.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neurotoxicology. 2016 Mar ;53:173-85. Epub 2016 Jan 3. PMID: 26756313
Article Published Date : Feb 29, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Magnolol
Pharmacological Actions : Neuroprotective Agents
[+]

Magnolol alleviates Alzheimer's disease-like pathology in transgenic C. elegans.Mar 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Apr ;124:109886. Epub 2020 Jan 27. PMID: 32000045
Article Published Date : Mar 31, 2020
Study Type : Transgenic Animal Study
Additional Links
Substances : Magnolol
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Magnolol ameliorates behavioural impairments and neuropathology in a transgenic model of Alzheimer's disease.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:5920476. Epub 2020 Jul 3. PMID: 32714487
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Alzheimer's Disease, Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Magnolol ameliorates pneumonectomy and monocrotaline-induced pulmonary arterial hypertension.Nov 30, 2018

Pubmed Data : Phytomedicine. 2018 Dec 1 ;51:205-213. Epub 2018 Oct 4. PMID: 30466619
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Hypertension: Pulmonary
Pharmacological Actions : Antihypertensive Agents
[+]

Magnolol and honokiol protect the intestinal mucosal integrity and regulate gastrointestinal dysfunction.May 20, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2018 May 21 ;24:3348-3356. Epub 2018 May 21. PMID: 29782483
Article Published Date : May 20, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Honokiol, Magnolol
Diseases : Escherichia coli Infections
Pharmacological Actions : Gastroprotective
[+]

Magnolol attenuates concanavalin A-induced hepatic fibrosis.May 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Basic Clin Pharmacol Toxicol. 2017 Jun ;120(6):560-570. Epub 2017 Mar 7. PMID: 28032440
Article Published Date : May 31, 2017
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Hepatitis: Lectin-Induced (concanavalin)
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Magnolol attenuates the inflammation and enhances phagocytosis.Dec 31, 2018

Pubmed Data : Mol Immunol. 2019 Jan ;105:96-106. Epub 2018 Nov 27. PMID: 30500626
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Magnolol can improve cerebral ischemic stroke in rats.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Dec ;16(6):4423-4428. Epub 2018 Sep 28. PMID: 30542392
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Stroke: Ischemic
Pharmacological Actions : Brain-derived neurotrophic factor modulator, Neuroprotective Agents
[+]

Magnolol can reduce renal ischemia and reperfusion injury.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Chin Med. 2017 ;45(7):1421-1439. Epub 2017 Sep 25. PMID: 28946769
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Ischemia
Pharmacological Actions : Anti-Apoptotic, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
Additional Keywords : Phytotherapy
[+]

Magnolol could prevent the development and progression of mucositis induced by oxaliplatin through multipathway.Mar 12, 2019

Pubmed Data : Phytother Res. 2019 Mar 13. Epub 2019 Mar 13. PMID: 30868668
Article Published Date : Mar 12, 2019
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Chemotherapy-Induced Toxicity: Oxaliplatin, Mucositis
Pharmacological Actions : Chemoprotective Agents, Gastroprotective
[+]

Magnolol exerts antidepressant-like effects on behaviours by enhancing hippocampal neurogenesis.Oct 31, 2016

Pubmed Data : Phytother Res. 2016 Nov ;30(11):1856-1861. Epub 2016 Aug 11. PMID: 27510271
Article Published Date : Oct 31, 2016
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Neurogenesis
[+]

Magnolol exerts protective effects against steatosis and hyperlipidemia.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2018 ;9:147. Epub 2018 Feb 5. PMID: 29467759
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Hepatic Steatosis, Hyperlipidemia
Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic
[+]

Magnolol had protective effects on DSS-induced colitis and may be an alternative therapeutic reagent for colitis treatment.Feb 28, 2018

Pubmed Data : Life Sci. 2018 Mar 1 ;196:69-76. Epub 2018 Feb 2. PMID: 29355546
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Gastrointestinal Inflammation, Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Gastroprotective, Interleukin-12 downregulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Magnolol has a beneficial effect on lupus nephritis.Aug 02, 2017

Pubmed Data : Mol Med Rep. 2017 Aug 3. Epub 2017 Aug 3. PMID: 28791390
Article Published Date : Aug 02, 2017
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Lupus Nephritis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Magnolol has beneficial effects on cerebral injury and blood brain barrier dysfunction induced by ischemia-reperfusion.Jul 31, 2017

Pubmed Data : Metab Brain Dis. 2017 Aug ;32(4):1109-1118. Epub 2017 Apr 4. PMID: 28378105
Article Published Date : Jul 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Blood Brain Barrier
[+]

Magnolol inhibits sodium currents in freshly isolated mouse dorsal root ganglion neurons.Oct 15, 2020

Pubmed Data : Clin Exp Pharmacol Physiol. 2020 Oct 16. Epub 2020 Oct 16. PMID: 33064853
Article Published Date : Oct 15, 2020
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
[+]

Magnolol is a potential candidate for glioma treatment.May 31, 2018

Pubmed Data : J Neuropathol Exp Neurol. 2018 Jun 1 ;77(6):426-436. PMID: 29788114
Article Published Date : May 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Glioblastoma
Pharmacological Actions : Anti-metastatic
[+]

magnolol is a promising agent for the treatment of osteoporosis and associated disorders.Feb 17, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2019 Feb 18. Epub 2019 Feb 18. PMID: 30816431
Article Published Date : Feb 17, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Osteoporosis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Magnolol is a promising chemopreventive supplement for preventing chemotherapy-induced skeletal muscle atrophy associated with cancer cachexia.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(11):e0143594. Epub 2015 Nov 24. PMID: 26600425
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Magnolia, Magnolol
Diseases : Bladder Cancer, Cachexia: Cancer, Cachexia: Chemotherapy Induced
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
Additional Keywords : Gene Expression Regulation
[+]

Magnolol may be a promising chemoprotective agent for the prevention of muscle atrophy.Dec 31, 2019

Pubmed Data : Front Immunol. 2020 ;11:77. Epub 2020 Feb 7. PMID: 32117241
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Cachexia: Chemotherapy Induced, Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Anti-Cachexic Agents, Chemoprotective Agents
[+]

Magnolol might be a potent anti-inflammatory and anti-fibrotic agent against bleomycin-induced lung fibrosis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Med. 2015 ;8(9):15450-7. Epub 2015 Sep 15. PMID: 26629034
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Magnolol might be used as a potential treatment for alcoholic liver damage.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:1459. Epub 2019 Dec 5. PMID: 31920652
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Magnolol modulates brain injury caused by ischemic stroke by inhibiting inflammatory cytokines and apoptosis.Jan 09, 2017

Pubmed Data : Pharmacol Rep. 2017 Jan 10 ;69(4):642-647. Epub 2017 Jan 10. PMID: 28527875
Article Published Date : Jan 09, 2017
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Stroke: Attenuation/Recovery
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Magnolol post-treatment may reverse the neuronal damage in the MPTP-lesioned Parkinson's disease mice.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(3):e0173503. Epub 2017 Mar 3. PMID: 28257461
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Magnolol
Pharmacological Actions : Neuroprotective Agents
[+]

Magnolol protects against ischemic-reperfusion brain damage following oxygen-glucose deprivation and transient focal cerebral ischemia.Mar 31, 2018

Pubmed Data : Int J Mol Med. 2018 Apr ;41(4):2252-2262. Epub 2018 Jan 15. PMID: 29336466
Article Published Date : Mar 31, 2018
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Brain: Oxidative Stress, Brain Ischemia
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Magnolol reduced inflammatory injury and improved neurological outcomes in intracerebral haemorrhage model.Dec 27, 2018

Pubmed Data : Brain Behav Immun. 2018 Dec 28. Epub 2018 Dec 28. PMID: 30597199
Article Published Date : Dec 27, 2018
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Intracerebral Hemorrhage
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Magnolol-inhibited progression of colorectal cancer.May 15, 2020

Pubmed Data : Int J Mol Sci. 2020 May 16 ;21(10). Epub 2020 May 16. PMID: 32429376
Article Published Date : May 15, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

The present study highlighted the possibility of using magnolol as a novel therapeutic drug for hepatocellular carcinoma treatment.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2018 ;11:5219-5226. Epub 2018 Aug 28. PMID: 30214227
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

The protective effects of magnolol on acute trinitrobenzene sulfonic acid‑induced colitis in rats.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2018 Mar ;17(3):3455-3464. Epub 2017 Dec 20. PMID: 29286109
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation
[+]

These findings identify Magnolol as a promising candidate with anti-microtubule polymerization activity for NSCLC treatment.Jul 25, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2017 Jul 26 ;42(5):1789-1801. Epub 2017 Jul 26. PMID: 28746938
Article Published Date : Jul 25, 2017
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
[+]

These findings suggest that administration of magnolol could alleviate depressive-like behaviours.May 31, 2018

Pubmed Data : Int Immunopharmacol. 2018 Jun ;59:61-67. Epub 2018 Apr 5. PMID: 29627576
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Brain Inflammation , Depression
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These findings suggest that magnolol exerts anti-inflammatory effect on dextran sulfate sodium induced colitis.Jul 19, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2017 Jul 20 ;22(7). Epub 2017 Jul 20. PMID: 28726741
Article Published Date : Jul 19, 2017
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

This research suggested that magnolol possessed a new therapeutic potential for the development of osteoarthritis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:393. Epub 2019 Apr 16. PMID: 31040782
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Antifungal effects of phytocompounds on Candida species alone and in combination with fluconazole.Jan 31, 2017

Pubmed Data : Int J Antimicrob Agents. 2017 Feb ;49(2):125-136. Epub 2016 Dec 15. PMID: 28040409
Article Published Date : Jan 31, 2017
Study Type : Review
Additional Links
Substances : Honokiol, Magnolol, Shikonin
Diseases : Candida Infection
Pharmacological Actions : Antimicrobial
Additional Keywords : Natural Substance/Drug Synergy
[+]

Cardiovascular modulating effects of magnolol and honokiol.Oct 23, 2019

Pubmed Data : Curr Drug Targets. 2019 Oct 24. Epub 2019 Oct 24. PMID: 31749425
Article Published Date : Oct 23, 2019
Study Type : Review
Additional Links
Substances : Honokiol, Magnolia, Magnolol
Diseases : Atherosclerosis, Cardiac Hypertrophy, Hypertension, Thrombosis
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Hono-Mag exerts a synergistic anti-tumor effect by inhibiting cell proliferation and inducing autophagy and apoptosis in human GBM cells.Apr 10, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Apr 11. Epub 2016 Apr 11. PMID: 27074557
Article Published Date : Apr 10, 2016
Study Type : In Vitro Study
Additional Links
Substances : Honokiol, Magnolol
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation
Additional Keywords : Natural Substance Synergy, Superiority of Natural Substances versus Drugs
[+]

Improved oral bioavailability of magnolol by using a binary mixed micelle system.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Artif Cells Nanomed Biotechnol. 2018 ;46(sup2):668-674. Epub 2018 Sep 5. PMID: 30183380
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Additional Keywords : Bioavailability
[+]

In vitro antimicrobial and antipro-inflammation potential of honokiol and magnolol against oral pathogens and macrophages.Sep 22, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Formos Med Assoc. 2020 Sep 23. Epub 2020 Sep 23. PMID: 32978046
Article Published Date : Sep 22, 2020
Study Type : In Vitro Study
Additional Links
Substances : Honokiol, Magnolol
Diseases : Aggregatibacter actinomycetemcomitans Infection , Escherichia coli Infections, Periodontitis, Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Antimicrobial
[+]

Induction of apoptosis by magnolol via the mitochondrial pathway and cell cycle arrest in renal carcinoma cells.Jan 21, 2019

Pubmed Data : Biochem Biophys Res Commun. 2019 Jan 22 ;508(4):1271-1278. Epub 2018 Dec 17. PMID: 30573364
Article Published Date : Jan 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Kidney Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Insights on the multifunctional activities of magnolol.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2019 ;2019:1847130. Epub 2019 May 23. PMID: 31240205
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Magnolol
Diseases : Cancers: All, Inflammation, Porphyromonas gingivalis, Steptococcus Mutans Infections
Pharmacological Actions : Anti-Inflammatory Agents, Antimicrobial, Antioxidants, Antiproliferative , Apoptotic, Cardioprotective, Neuroprotective Agents
[+]

M. officinalis extract can be used as an antiviral food material to control norovirus foodborne diseases.Jul 22, 2020

Pubmed Data : Foodborne Pathog Dis. 2020 Jul 23. Epub 2020 Jul 23. PMID: 32716659
Article Published Date : Jul 22, 2020
Study Type : In Vitro Study
Additional Links
Substances : Honokiol, Magnolia, Magnolol
Diseases : Norovirus
Pharmacological Actions : Antiviral Agents
[+]

Magnolol alleviates IL-1β-induced dysfunction of chondrocytes.Jan 08, 2020

Pubmed Data : J Interferon Cytokine Res. 2020 Jan 9. Epub 2020 Jan 9. PMID: 31916911
Article Published Date : Jan 08, 2020
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Inflammation, Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Osteoprotective
[+]

Magnolol and honokiol are potentially useful for the treatment of drug-resistant S. aureus infections when used in combination with lower concentration of antibiotics.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2015 ;2015:283630. Epub 2015 Aug 19. PMID: 26357651
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Honokiol, Magnolia, Magnolol
Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Antimicrobial
Additional Keywords : Dose Response, Gene Expression Regulation, Natural Substance/Drug Synergy, Plant Extracts
[+]

Magnolol and honokiol showed a broad spectrum of synergistic potentiation of conventional antibacterial agents.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2015 ;15(1):425. Epub 2015 Dec 1. PMID: 26627468
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Honokiol, Magnolol
Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Antibiotic Resistance, Natural Substance/Drug Synergy, Natural Substances Versus Drugs, Resistance Reversal
Problem Substances : Antibiotics
[+]

Magnolol and polyphenol mixture remarkably induced cell apoptosis by arresting the cell cycle in the G0/G1 phase.Jun 02, 2016

Pubmed Data : Pharmacol Res. 2016 Jun 3 ;111:113-125. Epub 2016 Jun 3. PMID: 27268146
Article Published Date : Jun 02, 2016
Study Type : In Vitro Study
Additional Links
Substances : Magnolia, Magnolol
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Histone deacetylase inhibitor
[+]

Magnolol blocks migration in HCT116 cells by suppressing TGF-β signaling.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Oncol. 2019 ;9:752. Epub 2019 Oct 1. PMID: 31632899
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Transforming growth factor beta (TGF-β) inhibitor
[+]

Magnolol can significantly inhibit the proliferation and induce the apoptosis in HL-60 cells.Mar 31, 2016

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Apr ;24(2):388-93. PMID: 27150997
Article Published Date : Mar 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Promyelocytic leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Magnolol could inhibit the growth, migration and invasion of cholangiocarcinoma cells through regulation of NF-κB pathway.Aug 01, 2017

Pubmed Data : Biomed Pharmacother. 2017 Aug 2 ;94:474-480. Epub 2017 Aug 2. PMID: 28779709
Article Published Date : Aug 01, 2017
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Cholangiocarcinoma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix Metalloproteinase-7 (MMP-7) Inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
[+]

Magnolol enhances the therapeutic effects of TRAIL.Oct 07, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Oct 8 ;25(19). Epub 2020 Oct 8. PMID: 33050112
Article Published Date : Oct 07, 2020
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Kidney Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer
[+]

Magnolol induces apoptosis and inhibits ERK-modulated metastatic potential in hepatocellular carcinoma cells.Oct 31, 2018

Pubmed Data : In Vivo. 2018 Nov-Dec;32(6):1361-1368. PMID: 30348689
Article Published Date : Oct 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic
[+]

Magnolol induces apoptosis in osteosarcoma cells via G0/G1 phase arrest and p53-mediated mitochondrial pathway.Jun 02, 2019

Pubmed Data : J Cell Biochem. 2019 Jun 3. Epub 2019 Jun 3. PMID: 31155771
Article Published Date : Jun 02, 2019
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Magnolol induces human Ewing sarcoma SK-ES-1 cell apoptosis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2020 ;12(5):1672-1682. Epub 2020 May 15. PMID: 32509168
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Sarcoma: Ewing's
Pharmacological Actions : Apoptotic
[+]

Magnolol inhibits growth and induces apoptosis in esophagus cancer KYSE-150 cell lines via the MAP kinase pathway.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Thorac Dis. 2019 Jul ;11(7):3030-3038. PMID: 31463132
Article Published Date : Jun 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Esophageal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Magnolol inhibits Streptococcus suis-induced inflammation and ROS formation.Feb 28, 2018

Pubmed Data : Pol J Vet Sci. 2018 Mar ;21(1):111-118. PMID: 29624001
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Streptococcus Infections
Pharmacological Actions : Anti-Bacterial Agents
[+]

Magnolol is a promising leading compound in treating muscle atrophy induced by cancer cachexia.Jun 28, 2020

Pubmed Data : J Nat Med. 2020 Jun 29. Epub 2020 Jun 29. PMID: 32601830
Article Published Date : Jun 28, 2020
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Cachexia: Cancer
[+]

Magnolol may be a candidate for prevention and management of dental caries. Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Microbiol Immunol. 2016 Jan ;60(1):10-6. PMID: 26600203
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Magnolia, Magnolol
Diseases : Dental Caries, Streptococcus Infections
Pharmacological Actions : Anti-Bacterial Agents, Antimicrobial
Additional Keywords : Biofilm
[+]

Magnolol may effectively enhance anti-hepatocellular carcinoma ability of radiation.Jun 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : In Vivo. 2020 Jul-Aug;34(4):1789-1796. PMID: 32606148
Article Published Date : Jun 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Liver Cancer
Pharmacological Actions : Radiosensitizer
[+]

Magnolol might be of benefit to the treatment of refractory Candida infection.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2017 ;11:2653-2661. Epub 2017 Sep 6. PMID: 28919715
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Candida Infection
Pharmacological Actions : Antifungal Agents
[+]

Magnolol nanoparticles exhibit improved water solubility and suppress TNF-α-induced VCAM-1 expression in endothelial cells.Feb 28, 2017

Pubmed Data : J Biomed Nanotechnol. 2017 Mar ;13(3):255-68. PMID: 29381027
Article Published Date : Feb 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Atherosclerosis, Inflammation
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Cell Adhesion Molecule-1 Inhibitor
[+]

Magnolol prevents ossified tendinopathy.Apr 30, 2019

Pubmed Data : Int Immunopharmacol. 2019 May ;70:117-124. Epub 2019 Feb 22. PMID: 30798160
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Tendon Injury
Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation
[+]

Magnolol protects PC12 cells from hydrogen peroxide or 6-hydroxydopamine induced cytotoxicity.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Toxicol Sci. 2019 ;44(11):753-758. PMID: 31708532
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Magnolol, a natural compound, induces apoptosis of human gastric adenocarcinoma cells. Nov 30, 2011

Pubmed Data : Int J Oncol. 2011 Nov 30. Epub 2011 Nov 30. PMID: 22139054
Article Published Date : Nov 30, 2011
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Human Gastric Adenocarcinoma
Pharmacological Actions : Apoptotic
[+]

Mito-magnolol is significantly more potent than the FDA-approved OXPHOS inhibitor in inhibiting proliferation of melanoma cells.Sep 16, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Treat Res Commun. 2020 Sep 17 ;25:100210. Epub 2020 Sep 17. PMID: 32987287
Article Published Date : Sep 16, 2020
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Melanoma
Pharmacological Actions : Antiproliferative
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

The chemistry of magnolol and the molecular mechanism underlying the targets of magnolol against cancers are discussed.Jan 09, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2018 08 10 ;19(8). Epub 2018 Aug 10. PMID: 30103472
Article Published Date : Jan 09, 2018
Study Type : Review
Additional Links
Substances : Magnolol
Diseases : Cancers: All
Pharmacological Actions : Chemotherapeutic
[+]

The present study reveals a potential mechanism that explains the anti-atherogenic activity of magnolol.Jul 31, 2007

Pubmed Data : Int Immunopharmacol. 2007 Aug ;7(8):1083-91. Epub 2007 May 4. PMID: 17570325
Article Published Date : Jul 31, 2007
Study Type : In Vitro Study
Additional Links
Substances : Magnolia, Magnolol
Diseases : Atherosclerosis
Pharmacological Actions : Anti-atherogenic, Antiproliferative , Cell cycle arrest, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

The results suggest the promising use of magnolol in therapy for allergic asthma.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Physiol Pharmacol. 2019 Jul ;23(4):251-261. Epub 2019 Jun 25. PMID: 31297009
Article Published Date : Jun 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Asthma
Pharmacological Actions : Anti-Asthmatic Agents, Immunomodulatory
[+]

These results suggest that magnolol and honokiol are potential antifungal agents for application against plant fungal diseases.Jun 05, 2019

Pubmed Data : Molecules. 2019 Jun 6 ;24(11). Epub 2019 Jun 6. PMID: 31174300
Article Published Date : Jun 05, 2019
Study Type : Plant Study
Additional Links
Substances : Honokiol, Magnolol
Pharmacological Actions : Antifungal Agents
[+]

This study revealed a novel epigenetic mechanism of magnolol-induced cell death in melanoma.Feb 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Med. 2019 Mar ;8(3):1186-1196. Epub 2019 Feb 21. PMID: 30793515
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Melanoma
Pharmacological Actions : Apoptotic
[+]

This study suggests potential anti-amyloidogenic properties of magnolol and honokiol and their structure related derivatives.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2015 ;5:13556. Epub 2015 Sep 1. PMID: 26324190
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Honokiol, Magnolol
Diseases : Alzheimer's Disease, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Dose Response

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