Maitake Mushroom

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60 Diseases Researched for Maitake Mushroom
NameACCKFocus
Liver Cancer512Locked
Diabetes Mellitus: Type 2610Locked
Myelodysplastic Syndromes110Locked
Breast Cancer58Locked
Insulin Resistance36Locked
Immune Dysregulation: TH1/TH2 imbalance35Locked
Oxidative Stress45Locked
Breast Cancer: Triple Negative 24Locked
Cancers: All44Locked
Colon Cancer24Locked
High Fat Diet24Locked
Inflammation44Locked
Myelotoxicity24Locked
Allergies23Locked
Chemotherapy-Induced Toxicity23Locked
Chemotherapy-Induced Toxicity: Cisplatin23Locked
Gastric Cancer33Locked
Prostate Cancer23Locked
Aging: Brain 12Locked
Atherosclerosis12Locked
Chemotherapy Induced Myelotoxicity 12Locked
Chemotherapy-Induced Toxicity: Paclitaxel12Locked
Depression12Locked
Diabetes Mellitus: Type 112Locked
Diabetic Nephropathy12Locked
HSV-112Locked
Hepatic Steatosis12Locked
Hyperinsulinism12Locked
Hypertension12Locked
Hypoglycemia12Locked
Immune Disorders: Low Immune Function12Locked
Lipopolysaccharide-Induced Toxicity22Locked
Listeria Infections12Locked
Liver Disease12Locked
Low Immune Function: Splenic Dysfunction12Locked
Low Immune Function: Thymus Dysfunction12Locked
Lung Cancer22Locked
Memory Disorders12Locked
Neutropenia22Locked
Neutropenia: Chemotherapy Induced22Locked
Neutropenia: Cyclic22Locked
Nonalcoholic fatty liver disease (NAFLD)12Locked
Osteoporosis12Locked
Bladder Cancer11Locked
Cancer Metastasis11Locked
Cancers: Canine11Locked
Chemotherapy-Induced Toxicity: Doxorubicin11Locked
Colorectal Cancer11Locked
Coronavirus Infection11Locked
Dry Skin 11Locked
Endotoxemia11Locked
Enterovirus 7111Locked
Hyperglycemia11Locked
Influenza A11Locked
Kidney Cancer11Locked
Laryngeal Cancer11Locked
Leukopenia: Chemotherapy Induced11Locked
Neutropenia: Severe Congenital11Locked
Organ Transplantation11Locked
Tumors11Locked
44 Pharmacological Actions Researched for Maitake Mushroom
NameACCKFocus
Immunomodulatory1651Locked
Apoptotic1119Locked
Hypoglycemic Agents1016Locked
Antiproliferative 711Locked
Anti-Inflammatory Agents710Locked
Cell cycle arrest68Locked
Antioxidants67Locked
Autophagy Up-regulation27Locked
Hypolipidemic47Locked
Anti-Tumor35Locked
Anti-metastatic35Locked
Chemopreventive35Locked
Interleukin-12 upregulation35Locked
Interleukin-6 Downregulation35Locked
Alpha-glucosidase inhibitor 24Locked
Antiviral Agents34Locked
Hepatoprotective24Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor34Locked
Anti-Allergic Agents23Locked
Antihypertensive Agents23Locked
Chemotherapeutic23Locked
Cyclooxygenase 2 Inhibitors23Locked
Gastrointestinal Agents23Locked
Immunostimulatory23Locked
Angiogenesis Inhibitors12Locked
Anti-Bacterial Agents12Locked
Anticarcinogenic Agents12Locked
Antidepressive Agents12Locked
Enzyme Inhibitors12Locked
Hematopoietic22Locked
Interferon-gamma (IFN-gamma) inducer12Locked
Neuroprotective Agents12Locked
Osteogenic12Locked
Osteoprotective 12Locked
Renoprotective12Locked
Bcl-2 protein down-regulation11Locked
Cyclooxygenase Inhibitors11Locked
Cytotoxic11Locked
Interferon Inducers11Locked
Interleukin-18 upregulation11Locked
NF-kappaB Inhibitor11Locked
Nitric Oxide Enhancer11Locked
Tumor Necrosis Factor (TNF) Alpha Enhancer11Locked
Tumor Suppressor Protein p53 Upregulation11Locked
Related Topics

Maitake Mushroom is a Sub of the following Topic

View the Evidence:
79 Abstracts with Maitake Mushroom Research

[+]

Antitumor activities of Grifola frondosa polysaccharide.Jul 12, 2021

Pubmed Data : J Ethnopharmacol. 2021 Jul 13:114395. Epub 2021 Jul 13. PMID: 34271115
Article Published Date : Jul 12, 2021
Study Type : Meta Analysis, Review
Additional Links
Substances : Maitake Mushroom
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative
Additional Keywords : Polysaccharides
[+]

Meta-analysis on effect of Grifola frondosa polysaccharide in regulating in vivo immunoregulatory function.Nov 30, 2019

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2019 Dec ;44(23):5174-5183. PMID: 32237355
Article Published Date : Nov 30, 2019
Study Type : Meta Analysis
Additional Links
Substances : Maitake Mushroom
Pharmacological Actions : Immunomodulatory
Additional Keywords : Polysaccharides
[+]

A maitake mushroom extract has beneficial immunomodulatory potential in patients with myelodysplastic syndromes.Oct 28, 2014

Pubmed Data : Cancer Immunol Immunother. 2014 Oct 29. Epub 2014 Oct 29. PMID: 25351719
Article Published Date : Oct 28, 2014
Study Type : Human Study
Additional Links
Substances : Maitake Mushroom
Diseases : Myelodysplastic Syndromes
Pharmacological Actions : Immunomodulatory
Additional Keywords : Plant Extracts, Supplementation
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Combined application of Grifola frondosa and vitamin C induced cell apoptosis and autophagy in vitro.Sep 10, 2017

Pubmed Data : Apoptosis. 2017 Sep 11. Epub 2017 Sep 11. PMID: 28894987
Article Published Date : Sep 10, 2017
Study Type : Human In Vitro
Additional Links
Substances : Maitake Mushroom, Vitamin C
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
Additional Keywords : Polysaccharides
[+]

A polysaccharide, extract from Maitake, induces Th-1 dominant responses in cancer-bearing mice. Dec 01, 2002

Pubmed Data : Jpn J Pharmacol. 2002 Dec;90(4):357-60. PMID: 12501013
Article Published Date : Dec 01, 2002
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Immune Dysregulation: TH1/TH2 imbalance
Pharmacological Actions : Immunomodulatory
[+]

A selenium enriched polysaccharide from Grifola frondosa significantly inhibited the growth of Heps tumor in vivo.Dec 31, 2015

Pubmed Data : Int J Biol Macromol. 2016 Jan ;82:607-13. Epub 2015 Oct 30. PMID: 26522247
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom, Selenium
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Immunomodulatory
[+]

A water extract of maitake mushroom reduces circulating glucose/insulin concentrations in insulin-resistant mice. Jan 01, 2002

Pubmed Data : Diabetes Obes Metab. 2002 Jan;4(1):43-8. PMID: 11874441
Article Published Date : Jan 01, 2002
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Hyperinsulinism, Insulin Resistance
Pharmacological Actions : Hypoglycemic Agents
[+]

Anti-obesity effects of Grifola frondosa.Jun 22, 2021

Pubmed Data : Food Funct. 2021 Jun 23. Epub 2021 Jun 23. PMID: 34160500
Article Published Date : Jun 22, 2021
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : High Fat Diet, Obesity
Additional Keywords : Anti-Obesity Agents
[+]

Eringi, Maitake, and Bunashimeji mushrooms prevent atherosclerosis in apolipoprotein E-deficient mice. May 01, 2008

Pubmed Data : Nutr Res. 2008 May;28(5):335-42. PMID: 19083429
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Bunashimeji, Eringi mushroom , Maitake Mushroom
Diseases : Atherosclerosis
Pharmacological Actions : Hypolipidemic
[+]

G. frondosa may prevent the further development of NASH by improving the disorder of lipid metabolism in rats.Apr 30, 2015

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2015 May ;40(9):1808-11. PMID: 26323153
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Hepatic Steatosis, Liver Disease
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Hypolipidemic, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Griflola frondosa demonstrated the potential as a safe medical food supplement for depression.Nov 30, 2017

Pubmed Data : Pharm Biol. 2017 Dec ;55(1):299-305. PMID: 27937670
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Antidepressive Agents, Depression, Maitake Mushroom
[+]

Grifola frondosa extract and ergosterol reduce allergic reactions in an allergy mouse model by suppressing the degranulation of mast cells.Nov 30, 2019

Pubmed Data : Biosci Biotechnol Biochem. 2019 Dec ;83(12):2280-2287. Epub 2019 Aug 14. PMID: 31412751
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Allergies
Pharmacological Actions : Anti-Allergic Agents
Additional Keywords : Plant Extracts
[+]

Grifola frondosa extract reduces fat accumulation and improves health span in C. elegans.Nov 06, 2021

Pubmed Data : Nutrients. 2021 Nov 7 ;13(11). Epub 2021 Nov 7. PMID: 34836223
Article Published Date : Nov 06, 2021
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Aging, Obesity
Pharmacological Actions : Antioxidants
Additional Keywords : Anti-Obesity Agents
[+]

Grifola frondosa polysaccharides induce breast cancer cell apoptosis.Jul 25, 2017

Pubmed Data : Int J Mol Med. 2017 Jul 26. Epub 2017 Jul 26. PMID: 28765878
Article Published Date : Jul 25, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic
Additional Keywords : Polysaccharides
[+]

Hypoglycemic and hypolipidemic activities of Grifola frondosa polysaccharides.Nov 19, 2019

Pubmed Data : Int J Biol Macromol. 2019 Nov 20. Epub 2019 Nov 20. PMID: 31759027
Article Published Date : Nov 19, 2019
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Diabetes Mellitus: Type 2, High Fat Diet
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic
[+]

Immunomodulating glucans from Maitake and Shiitake mushrooms strongly stimulated both the cellular and humoral branch of immune reactions.Jan 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Transl Med. 2014 Feb ;2(2):14. PMID: 25332990
Article Published Date : Jan 31, 2014
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom, Shiitake Mushroom
Pharmacological Actions : Immunostimulatory
Additional Keywords : Plant Extracts
[+]

Maitake (G. frondosa) exhibits antitumor activity in colon tumor-bearing mice. Feb 01, 2010

Pubmed Data : J Med Food. 2010 Feb;13(1):20-30. PMID: 20136432
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Colon Cancer
Pharmacological Actions : Interferon-gamma (IFN-gamma) inducer, Interleukin-12 upregulation
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Maitake and Bitter Melon (Momordica charantia) contain alpha-glucosidase inhibitors which may have therapeutic value in diabetes type 2. Jul 01, 2002

Pubmed Data : Biosci Biotechnol Biochem. 2002 Jul;66(7):1576-8. PMID: 12224646
Article Published Date : Jul 01, 2002
Study Type : Animal Study
Additional Links
Substances : Bitter Melon, Maitake Mushroom
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Alpha-glucosidase inhibitor , Enzyme Inhibitors
[+]

Maitake beta-glucan enhances therapeutic effect and reduces myelosupression and nephrotoxicity of cisplatin in mice.May 01, 2009

Pubmed Data : Int Immunopharmacol. 2009 May;9(5):620-6. Epub 2009 Feb 26. PMID: 19249389
Article Published Date : May 01, 2009
Study Type : Animal Study
Additional Links
Substances : Beta-glucan, Maitake Mushroom
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Myelotoxicity
Additional Keywords : Antineoplastic Agents, Drug Side Effect Attenuation
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Maitake beta-glucan induces programmed cell death in human prostatic cancer cells. Jan 01, 2000

Pubmed Data : Boll Soc Ital Biol Sper. 2000 Jan-Feb;76(1-2):1-4. PMID: 10851301
Article Published Date : Jan 01, 2000
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic
[+]

Maitake beta-glucan promotes recovery of leukocytes and myeloid cell function in peripheral blood from paclitaxel hematotoxicity.Feb 06, 2010

Pubmed Data : Cancer Immunol Immunother. 2010 Feb 6. Epub 2010 Feb 6. PMID: 20140432
Article Published Date : Feb 06, 2010
Study Type : Animal Study
Additional Links
Substances : Beta-glucan, Maitake Mushroom
Diseases : Chemotherapy Induced Myelotoxicity , Chemotherapy-Induced Toxicity, Chemotherapy-Induced Toxicity: Paclitaxel, Myelotoxicity
Pharmacological Actions : Chemopreventive
Additional Keywords : Drug Side Effect Attenuation
[+]

Maitake contains a compound known as alpha-glucan which has antidiabetic activity, possibly through reducing insulin resistance. Apr 01, 2007

Pubmed Data : J Pharm Pharmacol. 2007 Apr;59(4):575-82. PMID: 17430642
Article Published Date : Apr 01, 2007
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Diabetes Mellitus: Type 2, Insulin Resistance
Pharmacological Actions : Hypoglycemic Agents
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Maitake contains a protein with anti-HSV-1 activity. Sep 01, 2007

Pubmed Data : Antiviral Res. 2007 Sep;75(3):250-7. Epub 2007 Apr 17. PMID: 17475344
Article Published Date : Sep 01, 2007
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : HSV-1
Pharmacological Actions : Antiviral Agents
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Maitake D-Fraction enhances antitumor effects and reduces immunosuppression by mitomycin-C in tumor-bearing mice.May 01, 2005

Pubmed Data : Nutrition. 2005 May;21(5):624-9. PMID: 15850970
Article Published Date : May 01, 2005
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Drug-Plant-Vitamin Synergies, Drug Side Effect Attenuation
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Maitake D-Fraction Pro4X prevents breast carcinogenesis, blocks tumor invasiveness, reduces angiogenesis, and increases overall survival.Jul 10, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Med. 2016 Jul 11. Epub 2016 Jul 11. PMID: 27401257
Article Published Date : Jul 10, 2016
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Breast Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Plant Extracts
[+]

Maitake D-fraction reduces the effective dosage of vancomycin for the treatment of Listeria-infected mice.Dec 01, 2001

Pubmed Data : Jpn J Pharmacol. 2001 Dec;87(4):327-32. PMID: 11829152
Article Published Date : Dec 01, 2001
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Listeria Infections
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Drug Sparing
[+]

Maitake enhances host innate immunity against foreign pathogens without eliciting adverse inflammatory response.Feb 01, 2008

Pubmed Data : J Pharm Pharmacol. 2008 Feb;60(2):237-43. PMID: 18237472
Article Published Date : Feb 01, 2008
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Immune Disorders: Low Immune Function
Pharmacological Actions : Immunomodulatory
Additional Keywords : Cytokine Storm
[+]

Maitake expresses anti-tumor effects by establishing a helper (TH)-1 dominance in mice. Mar 31, 2003

Pubmed Data : Cancer Lett. 2003 Mar 31;192(2):181-7. PMID: 12668282
Article Published Date : Mar 31, 2003
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Immune Dysregulation: TH1/TH2 imbalance
Pharmacological Actions : Anti-Tumor, Immunomodulatory
[+]

Maitake has antihypertensive effects in rats. Aug 01, 2002

Pubmed Data : Mol Cell Biochem. 2002 Aug;237(1-2):129-36. PMID: 12236580
Article Published Date : Aug 01, 2002
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
[+]

Maitake improves glycemic responses in diabetic rats.Jan 01, 2008

Pubmed Data : Am J Chin Med. 2008;36(2):265-85. PMID: 18457360
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Diabetes Mellitus: Type 1
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Maitake mushroom (SX-fraction) improves insulin sensitivity.Jul 01, 2008

Pubmed Data : Nat Med (Tokyo). 2008 Jul;62(3):284-93. Epub 2008 Feb 13. PMID: 17671829
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Insulin Resistance
Pharmacological Actions : Hypoglycemic Agents
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Maitake mushroom and its active fraction inhibit hepatoma growth by inducing autophagy and apoptosis.Mar 23, 2016

Pubmed Data : Exp Biol Med (Maywood). 2016 Mar 24. Epub 2016 Mar 24. PMID: 27013543
Article Published Date : Mar 23, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation, Cell cycle arrest
Additional Keywords : Plant Extracts
[+]

Maitake mushroom possesses anti-α-glucosidase activity, and hypoglycemic effect in HFD + STZ-induced hyperglycemic mice.Apr 30, 2015

Pubmed Data : Pharm Biol. 2015 May ;53(5):705-9. Epub 2014 Nov 28. PMID: 25431253
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Diabetes Mellitus: Type 2, High Fat Diet, Hypoglycemia, Oxidative Stress
Pharmacological Actions : Alpha-glucosidase inhibitor , Hypoglycemic Agents
[+]

Maitake stimulates immune function through enhancing the thymus index and splenic function in mice. Jan 01, 2003

Pubmed Data : Zhong Yao Cai. 2003 Jan;26(1):31-2. PMID: 12858772
Article Published Date : Jan 01, 2003
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Low Immune Function: Splenic Dysfunction, Low Immune Function: Thymus Dysfunction
Pharmacological Actions : Anti-Tumor, Immunomodulatory
[+]

Mushroom extracts decrease bone resorption and improve bone formation.Dec 31, 2015

Pubmed Data : Int J Med Mushrooms. 2016 ;18(7):559-69. PMID: 27649725
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom, Oyster Mushroom, Shiitake Mushroom
Diseases : Osteoporosis
Pharmacological Actions : Osteogenic, Osteoprotective
Additional Keywords : Plant Extracts
[+]

Novel medicinal mushroom blend as a promising supplement in integrative oncology.May 13, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 May 14 ;21(10). Epub 2020 May 14. PMID: 32423132
Article Published Date : May 13, 2020
Study Type : Animal Study
Additional Links
Substances : Agaricus Blazei, Maitake Mushroom, Reishi Mushroom, Shiitake Mushroom
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Chemotherapeutic, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation
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Soluble β-glucan from Grifola frondosa induces tumor regression in synergy with TLR9 agonist.Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Leukoc Biol. 2015 Dec ;98(6):1015-25. Epub 2015 Aug 21. PMID: 26297795
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Beta-glucan, Maitake Mushroom
Diseases : Colon Cancer
Pharmacological Actions : Immunomodulatory, Interleukin-12 upregulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

The hypoglycemic and renal protective effects of Grifola frondosa polysaccharides in early diabetic nephropathy.Oct 10, 2020

Pubmed Data : J Food Biochem. 2020 Oct 11:e13515. Epub 2020 Oct 11. PMID: 33043487
Article Published Date : Oct 10, 2020
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Hypoglycemic Agents, Renoprotective
Additional Keywords : Polysaccharides
[+]

The polysaccharides from the Grifola frondosa fruiting body prevent lipopolysaccharide/D-galactosamine-induced acute liver injury.Mar 14, 2021

Pubmed Data : Food Funct. 2021 Mar 15 ;12(5):1973-1982. PMID: 33586729
Article Published Date : Mar 14, 2021
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Lipopolysaccharide-Induced Toxicity, Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective, MicroRNA modulator, Nrf2 activation
Additional Keywords : Polysaccharides
[+]

The positive effects of Grifola frondosa heteropolysaccharide on NAFLD and regulation of the gut microbiota.Oct 23, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Oct 24 ;20(21). Epub 2019 Oct 24. PMID: 31653116
Article Published Date : Oct 23, 2019
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Gastrointestinal Agents, Hepatoprotective
[+]

The structural characteristics of an acid-soluble polysaccharide from Grifola frondosa and its antitumor effects on H22-bearing mice.May 09, 2020

Pubmed Data : Int J Biol Macromol. 2020 May 10. Epub 2020 May 10. PMID: 32437807
Article Published Date : May 09, 2020
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Immunomodulatory
Additional Keywords : Polysaccharides
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These findings indicated that oral administration of Grifola frondosa polysaccharides could improve memory impairment.Jul 27, 2017

Pubmed Data : Mol Nutr Food Res. 2017 Jul 28. Epub 2017 Jul 28. PMID: 28752930
Article Published Date : Jul 27, 2017
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom
Diseases : Aging: Brain , Memory Disorders
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Polysaccharides
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A comparative study on the structures of Grifola frondosa polysaccharides obtained by different decolourization methods and their in vitro antioxidant activities.Oct 15, 2019

Pubmed Data : Food Funct. 2019 Oct 16 ;10(10):6720-6731. PMID: 31566196
Article Published Date : Oct 15, 2019
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Endotoxemia, Oxidative Stress
Pharmacological Actions : Antioxidants
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A polysaccharide from Grifola frondosa fruit body induces HT-29 cells apoptosis by PI3K/AKT-MAPKs and NF-κB-pathway.Mar 14, 2020

Pubmed Data : Int J Biol Macromol. 2020 Mar 15 ;147:79-88. Epub 2020 Jan 8. PMID: 31923503
Article Published Date : Mar 14, 2020
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Polysaccharides
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A review of polysaccharides in Grifola frondosa mushroom and their health promoting properties.Jul 31, 2017

Pubmed Data : Int J Biol Macromol. 2017 Aug ;101:910-921. Epub 2017 Mar 31. PMID: 28366857
Article Published Date : Jul 31, 2017
Study Type : Review
Additional Links
Substances : Maitake Mushroom
Diseases : Cancers: All, Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Immunomodulatory
Additional Keywords : Antioxidants, Cancers: All, Diabetes mellitus: Type 2, Hypoglycemic Agents, Immunomodulatory, Maitake Mushroom, Polysaccharides
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A variety of mushroom inhibit breast cancer cell proliferation. Nov 01, 2010

Pubmed Data : Exp Biol Med (Maywood). 2010 Nov;235(11):1306-14. Epub 2010 Oct 4. PMID: 20921274
Article Published Date : Nov 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Crimini Mushroom, Maitake Mushroom, Oyster Mushroom, Portabella Mushroom, White Button Mushroom
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
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A β-glucan from Grifola frondosa effectively delivers therapeutic oligonucleotide into cells via dectin-1 receptor and attenuates TNFα gene expression.Apr 14, 2020

Pubmed Data : Int J Biol Macromol. 2020 Apr 15 ;149:801-808. Epub 2020 Jan 23. PMID: 31982530
Article Published Date : Apr 14, 2020
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
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An extract of Maitake mushroom reduced the migration and invasion of mammary tumor cells, generating less aggressive cell behaviours.Dec 31, 2016

Pubmed Data : Nutr Cancer. 2017 Jan ;69(1):29-43. Epub 2016 Nov 28. PMID: 27892708
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic
Additional Keywords : Plant Extracts
[+]

Anti-diabetic effects of Grifola frondosa bioactive compound and its related molecular signaling pathways in palmitate-induced C2C12 cells.Oct 04, 2020

Pubmed Data : J Ethnopharmacol. 2020 Oct 5 ;260:112962. Epub 2020 May 16. PMID: 32422357
Article Published Date : Oct 04, 2020
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants, Hypoglycemic Agents
[+]

Anti-inflammatory and immunomodulatory effects of the Grifola frondosa natural compound o-Orsellinaldehyde.May 27, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceutics. 2021 May 28 ;13(6). Epub 2021 May 28. PMID: 34071571
Article Published Date : May 27, 2021
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
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Antitumor, anti-inflammatory and antiallergic effects of Agaricus blazei mushroom extract and the related medicinal Basidiomycetes mushrooms.May 07, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 May 8 ;12(5). Epub 2020 May 8. PMID: 32397163
Article Published Date : May 07, 2020
Study Type : Review
Additional Links
Substances : Agaricus Blazei, Lion's Mane (Hericium Erinaceus), Maitake Mushroom
Diseases : Allergies, Cancers: All, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Allergic Agents, Anti-Inflammatory Agents, Antioxidants, Chemopreventive
[+]

Can medicinal mushrooms have prophylactic or therapeutic effect against COVID‐19 and its pneumonic superinfection and complicating inflammation?Jul 12, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Scand J Immunol. 2020 Jul 13:e12937. Epub 2020 Jul 13. PMID: 32657436
Article Published Date : Jul 12, 2020
Study Type : Review
Additional Links
Substances : Agaricus Blazei, Lion's Mane (Hericium Erinaceus), Maitake Mushroom
Diseases : Coronavirus Infection
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Extracts from medicinal basidiomycetes mushrooms had anti-tumor activity against cancer cell lines. Dec 31, 2015

Pubmed Data : Int J Med Mushrooms. 2016 ;18(11):955-964. PMID: 28008808
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom, Reishi Mushroom, Shiitake Mushroom
Diseases : Kidney Cancer, Laryngeal Cancer, Lung Cancer
Pharmacological Actions : Cytotoxic, Immunomodulatory
[+]

G. frondosa polysaccharide has antiviral activity.Jun 24, 2016

Pubmed Data : Carbohydr Polym. 2016 Jun 25 ;144:382-9. Epub 2015 Dec 30. PMID: 27083830
Article Published Date : Jun 24, 2016
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Enterovirus 71
Pharmacological Actions : Antiviral Agents, Apoptotic
Additional Keywords : Polysaccharides
[+]

Glucan from Grifola frondosa inhibits lipopolysaccharide-induced cytokine production.Jan 27, 2020

Pubmed Data : J Nat Prod. 2020 02 28 ;83(2):231-242. Epub 2020 Jan 22. PMID: 31967822
Article Published Date : Jan 27, 2020
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Polysaccharides
[+]

Glycoprotein GFG-3a induces apoptosis in human gastric cancer cells.Jan 31, 2016

Pubmed Data : Nutr Cancer. 2016 Feb-Mar;68(2):267-79. PMID: 27040446
Article Published Date : Jan 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
[+]

Grifola frondosa and Vitamin C had a synergistic apoptotic effect on SMMC-7721 liver cancer cells. May 04, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Cancer Ther. 2016 May 5. Epub 2016 May 5. PMID: 27151580
Article Published Date : May 04, 2016
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom, Vitamin C
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Natural Substance Synergy
[+]

Maitake (G. frondosa) enhances phagocytosis of human polymorphonuclear neutrophils (PMN). Apr 19, 2006

Pubmed Data : J Agric Food Chem. 2006 Apr 19;54(8):2906-14. PMID: 16608207
Article Published Date : Apr 19, 2006
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Neutropenia, Neutropenia: Chemotherapy Induced, Neutropenia: Cyclic, Neutropenia: Severe Congenital
[+]

Maitake appears to induce the production of certain factors, including TNF-alpha, which are responsible for the inhibition of viral growth in vitro.Apr 01, 2010

Pubmed Data : Pharm Biol. 2010 Apr;48(4):469-81. PMID: 19051344
Article Published Date : Apr 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Influenza A
Pharmacological Actions : Antiviral Agents, Tumor Necrosis Factor (TNF) Alpha Enhancer
[+]

Maitake beta-glucan MD-fraction enhances bone marrow colony formation and reduces doxorubicin toxicity in vitro.Jan 01, 2004

Pubmed Data : Int Immunopharmacol. 2004 Jan;4(1):91-9. PMID: 14975363
Article Published Date : Jan 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Hematopoietic
Additional Keywords : Colony-Stimulating Factors (CSFs)
[+]

Maitake contains cyclooxygenase inhibitory and antioxidant compounds. Nov 01, 2002

Pubmed Data : Endocr Pract. 2002 Nov-Dec;8(6):417-23. PMID: 12475274
Article Published Date : Nov 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
[+]

Maitake D-fraction (MDF) is a novel inducer for iNOS which contributes at least in part to antitumor activity of MDF.Dec 01, 2001

Pubmed Data : J Exp Clin Cancer Res. 2001 Dec;20(4):591-7. PMID: 11876556
Article Published Date : Dec 01, 2001
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Tumors
Pharmacological Actions : Immunomodulatory, Nitric Oxide Enhancer
[+]

Maitake D-Fraction establishes Th-1 dominance which induces cellular immunity in the population that was Th-2 dominant due to carcinoma.Apr 01, 2002

Pubmed Data : Biol Pharm Bull. 2002 Apr;25(4):536-40. PMID: 11995941
Article Published Date : Apr 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Immune Dysregulation: TH1/TH2 imbalance
Pharmacological Actions : Anti-Tumor, Interferon Inducers, Interleukin-12 upregulation, Interleukin-18 upregulation
[+]

Maitake D-Fraction exhibits synergistic anti-cancer activity with interferon in prostate cancer cells. Jan 01, 2008

Pubmed Data : J Hematol Oncol. 2008;1:25. Epub 2008 Dec 4. PMID: 19055833
Article Published Date : Jan 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Prostate Cancer
Pharmacological Actions : Cell cycle arrest
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Maitake D-fraction has potential growth inhibitory effects in canine cancer cells. Jan 01, 2004

Pubmed Data : Vet Ther. 2004;5(4):263-71. PMID: 15719326
Article Published Date : Jan 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Cancers: Canine
[+]

Maitake D-Fraction inhibit colon, lung and melanoma cell metastasis by activating Natural Killer (NK) cells. Jun 01, 2008

Pubmed Data : Biol Pharm Bull. 2008 Jun;31(6):1104-8. PMID: 18520039
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Cancer Metastasis, Lung Cancer
Pharmacological Actions : Immunomodulatory
[+]

Maitake enhances granulopoiesis and mobilization of granulocytes by increasing granulocyte colony-stimulating factor. Jun 30, 2009

Pubmed Data : Int Immunopharmacol. 2009 Jun 30. PMID: 19573626
Article Published Date : Jun 30, 2009
Study Type : Commentary
Additional Links
Substances : Maitake Mushroom
Diseases : Chemotherapy-Induced Toxicity, Chemotherapy-Induced Toxicity: Cisplatin, Leukopenia: Chemotherapy Induced, Neutropenia, Neutropenia: Chemotherapy Induced, Neutropenia: Cyclic
Additional Keywords : Colony-Stimulating Factors (CSFs)
[+]

Maitake induces programmed cell death in gastric cancer cells. Sep 01, 2009

Pubmed Data : Oncol Rep. 2009 Sep;22(3):615-20. PMID: 19639212
Article Published Date : Sep 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic
[+]

Maitake may have a therapeutic role in supporting engraftment in organ transplantation. Mar 01, 2009

Pubmed Data : Exp Biol Med (Maywood). 2009 Mar;234(3):342-53. Epub 2009 Jan 14. PMID: 19144872
Article Published Date : Mar 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Organ Transplantation
Pharmacological Actions : Hematopoietic
[+]

Maitake may have a therapeutic role in the treatment of dry skin. Dec 27, 2002

Pubmed Data : J Biol Chem. 2002 Dec 27;277(52):50341-7. Epub 2002 Oct 16. PMID: 19228191
Article Published Date : Dec 27, 2002
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Dry Skin
[+]

Maitake mushroom d-fraction exhibits a synergistic effect with interferon on inhibiting bladder cancer cells. Sep 04, 2009

Pubmed Data : BJU Int. 2009 Sep 4. Epub 2009 Sep 4. PMID: 19735256
Article Published Date : Sep 04, 2009
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Bladder Cancer
Pharmacological Actions : Cell cycle arrest
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Potential activity of albino Grifola frondosa mushroom extract against biofilm of meticillin-resistant Staphylococcus aureus.Jul 09, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Fungi (Basel). 2021 Jul 10 ;7(7). Epub 2021 Jul 10. PMID: 34356930
Article Published Date : Jul 09, 2021
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Anti-Bacterial Agents
[+]

Purification, characterization and immunomodulatory activity of a novel polysaccharide from Grifola frondosa.Jan 20, 2018

Pubmed Data : Int J Biol Macromol. 2018 Jan 21. Epub 2018 Jan 21. PMID: 29395342
Article Published Date : Jan 20, 2018
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Cancers: All
Pharmacological Actions : Chemotherapeutic, Immunomodulatory
Additional Keywords : Polysaccharides
[+]

Structural elucidation and immune-enhancing effects of novel polysaccharide from Grifola frondosa.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2019 ;2019:7528609. Epub 2019 Apr 16. PMID: 31139649
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Pharmacological Actions : Antihypertensive Agents, Hypoglycemic Agents, Immunostimulatory
Additional Keywords : Polysaccharides
[+]

Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2019 ;14(11):e0224740. Epub 2019 Nov 7. PMID: 31697749
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom, Reishi Mushroom, Shiitake Mushroom
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Immunomodulatory
Additional Keywords : Natural Substance Synergy
[+]

The preparation of a cold-water soluble polysaccharide from Grifola frondosa and its inhibitory effects on MKN-45 cells.Dec 31, 2019

Pubmed Data : Glycoconj J. 2020 08 ;37(4):413-422. Epub 2020 Jun 15. PMID: 32556780
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest
[+]

Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases.Apr 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2021 May ;137:111377. Epub 2021 Feb 15. PMID: 33601145
Article Published Date : Apr 30, 2021
Study Type : Review
Additional Links
Substances : Lion's Mane (Hericium Erinaceus), Maitake Mushroom, Medicinal Mushrooms
Diseases : Alzheimer's Disease, Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Water extract of Grifola frondosa could be provided as a potential candidate to regulate glycolipid metabolism and gut microbiota.Jul 14, 2020

Pubmed Data : Int J Biol Macromol. 2020 Jul 15 ;155:1030-1039. Epub 2019 Nov 8. PMID: 31712147
Article Published Date : Jul 14, 2020
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Hyperglycemia
Pharmacological Actions : Gastrointestinal Agents, Hypoglycemic Agents, Hypolipidemic
[+]

YM-2A might be a candidate for an oral therapeutic agent in cancer immunotherapy.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(3):e0173621. Epub 2017 Mar 9. PMID: 28278221
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom
Diseases : Cancers: All
Pharmacological Actions : Immunomodulatory

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