Mangifera indica

Name	AC	CK
Athletic Performance	4	40
Diabetes Mellitus: Type 2	12	37
Steptococcus Mutans Infections	4	33
Oxidative Stress	13	24
Inflammation	15	23
Staphylococcus aureus infection	2	22
Pseudomonas aeruginosa	1	21
Cognitive Decline/Dysfunction	3	14
Alzheimer's Disease	8	13
Chemically-Induced Liver Damage	6	13
Inflammatory Bowel Diseases	2	12
Insulin Resistance	6	12
Lipopolysaccharide-Induced Toxicity	10	12
Obesity	6	12
Gastrointestinal Inflammation	2	11
Parkinson's Disease	6	11
Cancers: All	9	10
Colorectal Cancer	6	10
Constipation	1	10
Dental Plaque	1	10
Diabetic Nephropathy	5	10
Gastrointestinal Infections	1	10
Upper Respiratory Infections	1	10
Allergies	4	9
Arthritis	4	9
Breast Cancer	7	9
Mercury Poisoning	4	9
Osteoarthritis	6	9
High Fat Diet	4	8
Hyperglycemia	5	8
Nonalcoholic fatty liver disease (NAFLD)	4	8
Depression	4	7
Ovarian Cancer	5	7
Wound Healing	3	7
Chemotherapy-Induced Toxicity: Cisplatin	3	6
Colitis	3	6
Colon Cancer	5	6
Gastric Ulcer	2	6
Kidney Damage	3	6
Lung Cancer	5	6
Neuropathic Pain	3	6
Brain: Oxidative Stress	3	5
Lung Injury: Acute	3	5
Acetaminophen (Tylenol) Toxicity	2	4
Arsenic Poisoning	2	4
Arteriosclerosis	2	4
Chemotherapy-Induced Toxicity: Cyclophosphamide	2	4
Diabetes: Cardiovascular Illness	2	4
Heart Failure	2	4
Hyperlipidemia	2	4
Hypersensitivity	1	4
Hyperuricemia	2	4
Ischemia	2	4
Liver Fibrosis	2	4
Metabolic Syndrome X	3	4
Myocardial Fibrosis	2	4
Myocardial Infarction	2	4
Neurodegenerative Diseases	4	4
Osteoporosis	3	4
Parasitic Diseases	1	4
Prostate Cancer	3	4
Pulmonary Fibrosis	2	4
Pulmonary Fibrosis: Bleomycin-Induced	2	4
Sepsis	2	4
Testicular Injury: Chemical/Metal Induced	2	4
Ulcerative Colitis	2	4
Acne	1	3
Allergic Rhinitis	2	3
Breast Cancer: Triple Negative	3	3
Cadmium Poisoning	2	3
Carcinoma: Non-Small-Cell Lung	2	3
Dental Caries	3	3
Depression: Postpartum	1	3
Fever	1	3
Herpes Simplex Virus Type 1	2	3
Hypoglycemia	2	3
Liver Cancer	2	3
Memory Disorders	2	3
Oral Cancer	2	3
Periodontitis	2	3
Snake Bite: Venom Toxicity	2	3
Tumors	2	3
Acute Myeloid Leukemia	1	2
Aging	2	2
Aging: Heart	1	2
Alcoholic Liver Disease	1	2
Allodynia	1	2
Aluminum Toxicity	1	2
Anaphylaxis	1	2
Aneurysmal subarachnoid hemorrhage (SAH)	1	2
Anxiety Disorders	1	2
Bone Fractures	1	2
Brain Cancer	2	2
Brain Damage: Hypoxic Ischemic Insult	1	2
Brain Injury: Traumatic	1	2
Breast Cancer: Chemically-Induced	1	2
Cancer Metastasis	1	2
Cardiomyopathy: Hypertrophic	1	2
Cerebral Ischemia	1	2
Cervical Cancer	2	2
Chronic Pain	1	2
Colon Polyps	1	2
Coronavirus Infection	2	2
Dementia	1	2
Dermatitis	1	2
Diabetes Mellitus: Type 1	2	2
Diabetes Mellitus: Type 1: Prevention	1	2
Diabetes: Kidney Function	1	2
Diabetic Complications	2	2
Drug Toxicity: Methotrexate	1	2
Dysbiosis	1	2
Dyslipidemias	1	2
Formaldehyde Toxicity	1	2
Gestational Diabetes	1	2
HSV-1	2	2
Huntington Disease	1	2
Hydrogen Peroxide Induced Toxicity	2	2
Hyperalgesia	1	2
Hypercholesterolemia	1	2
Hyperinsulinism	1	2
Hypertension	1	2
Hypothyroidism	1	2
Immune Disorders: Low Immune Function	1	2
Infertility: Male	1	2
Intervertebral Disk Displacement	1	2
Iron Overload	1	2
Ischemia: Myocardial	1	2
Kidney Damage: Drug-Induced	1	2
Leukemia	2	2
Lipid Peroxidation	1	2
Liver Cirrhosis	1	2
Liver Damage: Drug-Induced	1	2
Liver Injury: Ischemia/reperfusion	1	2
Lymph node carcinoma of the prostate (LNCaP)	1	2
Melanoma: Metastasis	1	2
Memory Loss	1	2
Multiple Myeloma	2	2
Myocardial Ischemia	2	2
Pain	1	2
Pesticide Toxicity	1	2
Pre-Eclampsia	1	2
Prediabetes	1	2
Pruritus	1	2
Radiation Induced Illness	2	2
Renal Fibrosis	1	2
Renal tubulointerstitial fibrosis	1	2
Rheumatoid Arthritis	2	2
Schizophrenia	1	2
Triglycerides: Elevated	1	2
Weight Gain: Drug-Induced	1	2
5alpha-dihydrotestosterone (DHT): Elevated Levels/Activity	1	1
Advanced Glycation End products (AGE)	1	1
Aging Skin	1	1
Air Pollution Linked Toxicity	1	1
Asthma	1	1
Atherosclerosis	1	1
Atopic Dermatitis	1	1
Bone Diseases	1	1
Brain Inflammation	1	1
Burkitt Lymphoma	1	1
Candida Albicans	1	1
Chemotherapy-Induced Toxicity: Doxorubicin	1	1
Chronic Kidney Disease (CKD)	1	1
Chronic Obstructive Lung Disease	1	1
Dengue	1	1
Diabetes: Oxidative Stress	1	1
Diabetic Retinopathy	1	1
Endothelial Dysfunction	1	1
Fibrosarcoma	1	1
Fibrosis	1	1
Fluoride Toxicity	1	1
Fungus Diseases	1	1
Gastric Cancer	1	1
Glioblastoma	1	1
Gram-Negative Bacterial Infections	1	1
Gram-Positive Bacterial Infections	1	1
HIV Infections	1	1
HSV-2	1	1
Heavy Metal Toxicity	1	1
Helicobacter Pylori Infection	1	1
High Sugar Diet	1	1
Hypoxia	1	1
Insomnia	1	1
Kidney Diseases	1	1
Kidney Fibrosis	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Leukemia: Chronic Lymphocytic Leukemia (CLL)	1	1
Liver Damage	1	1
Liver Disease	1	1
Mastitis	1	1
Melanoma: Metastatic	1	1
Mitochondrial Dysfunction	1	1
Mycobacterium tuberculosis	1	1
Mycotoxin Toxicity	1	1
Osteosarcoma	1	1
Periodontal Diseases	1	1
Porphyromonas gingivalis	1	1
Promyelocytic leukemia	1	1
Prostatic Hyperplasia: Benign	1	1
Psychiatric Disorders	1	1
Retroviruses	1	1
Smoking	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Streptococcus Infections	1	1
Stroke	1	1

Name	AC	CK
Anti-Inflammatory Agents	92	186
Antioxidants	65	121
Neuroprotective Agents	27	55
Hypoglycemic Agents	18	49
Tumor Necrosis Factor (TNF) Alpha Inhibitor	24	44
Hepatoprotective	21	39
NF-kappaB Inhibitor	25	39
Antimicrobial	5	34
Antiproliferative	23	29
Anti-Apoptotic	15	24
Interleukin-6 Downregulation	15	24
Anticholesteremic Agents	3	23
Apoptotic	20	23
Gastrointestinal Agents	4	23
Cardioprotective	13	22
Interleukin-1 beta downregulation	14	22
Nrf2 activation	13	20
Renoprotective	11	20
Immunomodulatory	12	19
Anti-metastatic	12	16
Anti-Fibrotic	7	13
Chemotherapeutic	11	13
Antiviral Agents	11	12
Anti-Bacterial Agents	8	11
Interleukin-8 downregulation	2	11
Anti-Allergic Agents	5	10
Anticarcinogenic Agents	5	10
Chemopreventive	7	10
Cyclooxygenase 2 Inhibitors	8	10
Hypolipidemic	6	10
Angiogenesis Inhibitors	5	9
Antidepressive Agents	4	9
Heme oxygenase-1 up-regulation	6	9
Chemoprotective Agents	5	8
Matrix metalloproteinase-9 (MMP-9) inhibitor	5	7
Pancreato Protective Agents	4	7
Superoxide Dismutase Up-regulation	4	7
Alpha-glucosidase inhibitor	4	6
Analgesics	4	6
Anti-Ulcer Agents	2	6
Chemosensitizer	4	6
Interleukin-18 down-regulation	4	6
Malondialdehyde Down-regulation	3	6
Matrix metalloproteinase-2 (MMP-2) inhibitor	4	6
MicroRNA modulator	5	6
Osteoprotective	4	6
Antineoplastic Agents	3	5
Antiparasitic Agents	2	5
Cell cycle arrest	4	5
Cytoprotective	4	5
Wnt/β-catenin signaling pathway modulation	3	5
Alpha-amylase inhibitor	2	4
Anti-pyretic	2	4
Antinoceceptive	2	4
Autophagy Inhibitors	3	4
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	2	4
Radioprotective	4	4
Catalase Up-Regulation	2	3
Fibroblast growth factor 21 upregulation	1	3
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	3	3
SIRT1 Activator	2	3
Uricosuric Agents	2	3
Adiponectin upregulation	1	2
Angiotensin-Converting Enzyme Inhibitors	1	2
Anti-Adipogenic	1	2
Antifungal Agents	2	2
Antihypertensive Agents	1	2
Autophagy Up-regulation	2	2
Cyclooxygenase Inhibitors	1	2
Cytotoxic	2	2
Enzyme Inhibitors	2	2
Immunomodulatory: Th17 downregulation	1	2
Immunostimulatory	1	2
Insulin Sensitizers	1	2
Interferon Gamma Reducer	1	2
NF-E2-Related Factor-2 (Nrf2) Modulator	1	2
Nitric Oxide Enhancer	1	2
Prophylactic Agents	1	2
STAT3 Inhibitor	2	2
Transforming growth factor beta (TGF-β) inhibitor	1	2
Transforming growth factor beta (TGF-β) upregulation	1	2
Vasoprotective	1	2
Xanthine oxidase inhibitor	1	2
5-alpha reductase inhibitor	1	1
Anti-Angiogenic	1	1
Anti-Asthmatic Agents	1	1
Anti-Glycation Agents	1	1
Anti-HIV Agents	1	1
Anti-atherogenic	1	1
Antidiarrheals	1	1
Antilipolytic	1	1
Antimalarials	1	1
Antimutagenic Agents	1	1
Bcl-2 protein down-regulation	1	1
Chelating Agents	1	1
ER beta receptor up-regulation	1	1
Genoprotective	1	1
Insulin-releasing	1	1
Nitric Oxide Inhibitor	1	1
Radiosensitizer	1	1
Tumor Suppressor Protein p53 Upregulation	1	1
Vascular Endothelial Growth Factor Inhibitors	1	1
p300/NF-κB down-regulation	1	1

[+]

The potential of α-mangostin from Garcinia mangostana as an effective antimicrobial agent.May 25, 2022

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Pubmed Data : Nutrients. 2023 Jun 23 ;15(13). Epub 2023 Jun 23. PMID: 37447175

Article Published Date : Jun 22, 2023

Study Type : Human Study

Additional Links

Substances : Mango , Quercetin

Diseases : Athletic Performance

Therapeutic Actions : Exercise

Additional Keywords : Plant Extracts

[+]

A single dose of mango leaf extract in combination with quercetin enhances peak power output during repeated sprint exercise.Oct 27, 2019

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Mangiferin alleviates postpartum depression-like behaviors.Dec 31, 2021

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Pubmed Data : Front Pharmacol. 2022 ;13:840567. Epub 2022 Jun 3. PMID: 35721155

Article Published Date : Dec 31, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Mangiferin

Diseases : Depression: Postpartum

Pharmacological Actions : Antidepressive Agents

[+]

Mangiferin ameliorates obesity-associated inflammation and autophagy in high-fat-diet-fed mice.Dec 04, 2022

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[+]

Alpha-mangostin treats early-stage adjuvant-induced arthritis.Dec 31, 2021

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Pubmed Data : Drug Des Devel Ther. 2022 ;16:509-520. Epub 2022 Feb 27. PMID: 35250263

Pubmed Data : Metab Brain Dis. 2022 Mar 28. Epub 2022 Mar 28. PMID: 35344129

Article Published Date : Mar 27, 2022

Study Type : Animal Study

Additional Links

Substances : Mango

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

[+]

Attenuating effects of Mangifera indica leaves ethanolic extract against acetamiprid induced reproductive toxicity.Dec 31, 2018

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Pubmed Data : Vet Res Forum. 2019 ;10(3):187-192. Epub 2019 Sep 15. PMID: 31737226

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Mango

Diseases : Infertility: Male, Pesticide Toxicity

Pharmacological Actions : Cytoprotective

Additional Keywords : Plant Extracts

Problem Substances : Pesticides

[+]

Effect of alpha-mangostin in the prevention of behavioural and neurochemical defects in methylmercury-induced neurotoxicity.Dec 31, 2021

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Pubmed Data : Toxicol Rep. 2022 ;9:977-998. Epub 2022 Apr 22. PMID: 35783250

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Mango

Diseases : Mercury Poisoning

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Mercury

[+]

Extracts of mango fruit improve memory in rats. Jul 01, 2009

Pubmed Data : Cancer Lett. 1987 Nov;37(3):293-9. PMID: 3677060

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Pubmed Data : Food Chem Toxicol. 2019 Feb 12 ;126:41-55. Epub 2019 Feb 12. PMID: 30769048

Article Published Date : Feb 11, 2019

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Arsenic Poisoning

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

Problem Substances : Arsenic

[+]

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Pubmed Data : Biomed Pharmacother. 2019 Jun 15 ;117:109097. Epub 2019 Jun 15. PMID: 31212128

Article Published Date : Jun 14, 2019

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Mangiferin ameliorates cardiac fibrosis in D-galactose-induced aging.Feb 28, 2021

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Mangiferin inhibits bowel carcinogenesis in male rats.Feb 26, 2001

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Pubmed Data : Cancer Lett. 2001 Feb 26;163(2):163-70. PMID: 11165750

Article Published Date : Feb 26, 2001

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Colon Cancer, Colon Polyps

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive

Additional Keywords : Xanthones

[+]

Mangiferin inhibits high-fat diet induced vascular injury via regulation of PTEN/AKT/eNOS pathway.Jun 30, 2018

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Pubmed Data : Int Immunopharmacol. 2016 May ;34:220-8. Epub 2016 Mar 9. PMID: 26971225

Article Published Date : Apr 30, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Mangiferin

Diseases : Colitis

Pharmacological Actions : Immunomodulatory: Th17 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Mangiferin may be considered a potential antineoplastic drug for the future treatment of cancer.Mar 31, 2016

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Pubmed Data : Mol Med Rep. 2016 Apr ;13(4):3423-32. Epub 2016 Feb 29. PMID: 26935347

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Pubmed Data : J Cell Mol Med. 2021 Feb 1. Epub 2021 Feb 1. PMID: 33523605

Article Published Date : Jan 31, 2021

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Heart Failure, Myocardial Infarction

Pharmacological Actions : Cardioprotective

[+]

Mangiferin promotes osteogenic differentiation and alleviates osteoporosis.Dec 31, 2021

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Pubmed Data : J Trace Elem Med Biol. 2015 Jul ;31:107-12. Epub 2015 Apr 22. PMID: 26004900

Article Published Date : Jun 30, 2015

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Aluminum Toxicity , Brain: Oxidative Stress, Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Aluminum Chloride

[+]

Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats.Jul 15, 2002

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Pubmed Data : Toxicology. 2002 Jul 15;176(3):165-73. PMID: 12093613

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Pubmed Data : Front Pharmacol. 2018 ;9:638. Epub 2018 Jun 18. PMID: 29967581

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Pubmed Data : Life (Basel). 2022 Apr 5 ;12(4). Epub 2022 Apr 5. PMID: 35455025

Article Published Date : Apr 04, 2022

Study Type : Animal Study

Additional Links

Substances : Mango

Diseases : Prediabetes

Pharmacological Actions : Alpha-amylase inhibitor, Alpha-glucosidase inhibitor , Hypoglycemic Agents

[+]

Mango fruit powder intake exerts protective effects in the initial steps of insulin resistance and hepatic lipid accumulation.Dec 31, 2016

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Pubmed Data : J Nutr Biochem. 2016 Nov 15 ;41:12-19. Epub 2016 Nov 15. PMID: 27951515

Article Published Date : Nov 14, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Mango

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative

[+]

Mango seed kernel extract suppresses hyperglycemia.Nov 30, 2023

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Pubmed Data : Environ Sci Pollut Res Int. 2023 Dec ;30(59):123286-123308. Epub 2023 Nov 20. PMID: 37981611

Article Published Date : Nov 30, 2023

Study Type : Animal Study

Additional Links

Substances : Mango

Diseases : Hyperglycemia

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hypoglycemic Agents, Pancreato Protective Agents

Additional Keywords : Plant Extracts

[+]

Mango supplementation modulates gut microbial dysbiosis.Jul 31, 2016

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Pubmed Data : Front Pharmacol. 2023 ;14:1189957. Epub 2023 Jul 13. PMID: 37521470

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Huntington Disease

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Our study indicates that mangiferin is a promising prodrug for the therapy of NAFLD patients.Dec 31, 2020

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This review is an attempt to assess the antimicrobial efficacy of 10 plant extracts on dental caries and plaque microorganisms.Jun 30, 2015

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Pubmed Data : Pharmacogn Rev. 2015 Jul-Dec;9(18):87-92. PMID: 26392704

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Pubmed Data : Molecules. 2022 Apr 19 ;27(9). Epub 2022 Apr 19. PMID: 35565960

Article Published Date : Apr 18, 2022

Study Type : In Vitro Study

Additional Links

Substances : Mango

Diseases : Aging Skin

Pharmacological Actions : Enzyme Inhibitors

Additional Keywords : Plant Extracts, Xanthones

[+]

A novel drug combination of mangiferin and cinnamic acid alleviates rheumatoid arthritis.Dec 31, 2021

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Pubmed Data : Front Immunol. 2022 ;13:912933. Epub 2022 Jun 21. PMID: 35799788

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Pubmed Data : Int J Mol Sci. 2022 Sep 4 ;23(17). Epub 2022 Sep 4. PMID: 36077522

Article Published Date : Sep 03, 2022

Study Type : In Vitro Study

Additional Links

Substances : Mangiferin

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Anti-inflammatory and immunomodulatory activity of Mangifera indica L.May 31, 2022

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Pubmed Data : Pharmacol Res. 2022 Jun 1 ;182:106283. Epub 2022 Jun 1. PMID: 35662629

Article Published Date : May 31, 2022

Study Type : In Vitro Study

Additional Links

Substances : Mango

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Immunomodulatory

[+]

Click here to read the entire abstract

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Article Published Date : Sep 30, 2024

Study Type : In Vitro Study

Additional Links

Substances : Mangiferin

Diseases : Amyotrophic Lateral Sclerosis, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents, Nrf2 activation

[+]

Mangiferin alleviates cisplatin-induced ototoxicity in sensorineural hearing loss.Aug 31, 2024

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Pubmed Data : Biomed Pharmacother. 2024 Sep ;178:117174. Epub 2024 Aug 3. PMID: 39098177

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Mangiferin attenuates mercury chloride induced cytotoxicity and genotoxicity in liver cells.Feb 09, 2011

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Pubmed Data : J Biochem Mol Toxicol. 2011 Feb 9. Epub 2011 Feb 9. PMID: 21308892

Article Published Date : Feb 09, 2011

Study Type : In Vitro Study

Additional Links

Substances : Mangiferin

Diseases : Chemically-Induced Liver Damage, Mercury Poisoning

Pharmacological Actions : Hepatoprotective

[+]

Mangiferin attenuates myocardial ischemia-reperfusion injury.Dec 31, 2018

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Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2023 Oct ;31(5):1394-1402. PMID: 37846690

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Pubmed Data : Biofactors. 2016 May 24. Epub 2016 May 24. PMID: 27219011

Article Published Date : May 23, 2016

Study Type : Review

Additional Links

Substances : Mangiferin

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Mangiferin has potent antitumor, immunomodulatory and anti-HIV activity. Nov 01, 2009

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Pubmed Data : J Obstet Gynaecol. 2009 Nov;29(8):681-5. PMID: 8957579

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Mangiferin offers protection against deleterious effects of pharmaceuticals, heavy metals, and environmental chemicals.Sep 21, 2020

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Pubmed Data : Phytother Res. 2020 Sep 22. Epub 2020 Sep 22. PMID: 32961631

Article Published Date : Sep 21, 2020

Study Type : Review

Additional Links

Substances : Mangiferin

Diseases : Heavy Metal Toxicity

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Chelating Agents

Problem Substances : Heavy Metals

[+]

Mangiferin positively regulates osteoblast differentiation and suppresses osteoclast differentiation.Jul 31, 2017

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Pubmed Data : Mol Med Rep. 2017 Aug ;16(2):1328-1332. Epub 2017 Jun 12. PMID: 28627701

Article Published Date : Jul 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Mangiferin

Diseases : Bone Diseases, Osteoarthritis

[+]

Mangiferin potentiates the activity of antifungal agents against fluconazole-resistant Candida.Aug 31, 2024

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Pubmed Data : Future Microbiol. 2024 Sep ;19(13):1157-1170. Epub 2024 Jul 16. PMID: 39012219

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Pubmed Data : Environ Mol Mutagen. 2005 Jul;46(1):12-21. PMID: 15795888

Article Published Date : Jul 01, 2005

Study Type : In Vitro Study

Additional Links

Substances : Mangiferin

Diseases : Radiation Induced Illness

Pharmacological Actions : Antioxidants, Antiproliferative , Genoprotective, Radioprotective

Additional Keywords : Xanthones

[+]

Mangiferin protects mitochondrial function in endothelial cells.May 02, 2017

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Pubmed Data : Biochim Biophys Acta. 2017 May 3. Epub 2017 May 3. PMID: 28478227

Article Published Date : May 02, 2017

Study Type : In Vitro Study

Additional Links

Substances : Mangiferin

Diseases : Mitochondrial Dysfunction

[+]

Mangiferin protects osteoblast against oxidative damage.Sep 22, 2017

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Pubmed Data : Biochem Biophys Res Commun. 2017 Sep 23 ;491(3):807-813. Epub 2017 Jun 30. PMID: 28669729

Article Published Date : Sep 22, 2017

Study Type : In Vitro Study

Additional Links

Substances : Mangiferin

Diseases : Osteoporosis, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants

Additional Keywords : Xanthones

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Mangiferin relieves lipopolysaccharide-induced injury by up-regulating miR-181a via targeting PTEN in ATDC5 cells.Dec 31, 2019

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Pubmed Data : Nutrients. 2016 ;8(7). Epub 2016 Jun 28. PMID: 27367721

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Pubmed Data : Pharmacol Res. 2019 Jul 2 ;146:104336. Epub 2019 Jul 2. PMID: 31271846

Article Published Date : Jul 01, 2019

Study Type : Review

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Substances : Mangiferin

Diseases : Alzheimer's Disease, Parkinson's Disease

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

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Mangiferin: A natural bioactive immunomodulating glucosylxanthone with potential against cancer and rheumatoid arthritis.Jun 30, 2024

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Pubmed Data : J Biochem Mol Toxicol. 2024 Jul ;38(7):e23765. PMID: 38967724

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Pubmed Data : Crit Rev Food Sci Nutr. 2020 Jun 8:1-27. Epub 2020 Jun 8. PMID: 32506936

Article Published Date : Jun 07, 2020

Study Type : Review

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Substances : Mango

Diseases : Cancers: All

Pharmacological Actions : Chemopreventive

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The standard aqueous stem bark extract of Mangifera indica L. inhibits toxic PLA2 - NN-XIb-PLA2 of Indian cobra venom.Apr 30, 2016

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Pubmed Data : Saudi Pharm J. 2016 May ;24(3):371-8. Epub 2016 Apr 30. PMID: 27275129

Article Published Date : Apr 30, 2016

Study Type : In Vitro Study

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Substances : Mango

Diseases : Snake Bite: Venom Toxicity

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Plant Extracts

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The study also highlights mangiferin as a promising Wnt inhibitor for liver cancer treatment.Dec 31, 2017

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View the Evidence: 300 Abstracts with Mangifera indica Research

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The potential of α-mangostin from Garcinia mangostana as an effective antimicrobial agent.May 25, 2022

Oral administration of mangiferin ameliorates diabetes.Dec 31, 2020

A mango juice by-product reduces gastrointestinal and upper respiratory tract infection symptoms in children.Sep 30, 2020

A mango leaf extract (Zynamite®) combined with quercetin has exercise-mimetic properties in human skeletal muscle.Jun 22, 2023

A single dose of mango leaf extract in combination with quercetin enhances peak power output during repeated sprint exercise.Oct 27, 2019

Acute effects of a polyphenol-rich leaf extract of Mangifera indica on cognitive function in healthy adults.Jul 22, 2020

Consumption of mango improves symptoms and associated biomarkers of constipation beyond an equivalent amount of fiber.May 06, 2018

Enhancement of exercise performance by 48 hours, and 15-day supplementation with mangiferin and luteolin in men.Feb 05, 2019

Mango leaf mouthwash was effective against salivary microbial population, plaque inhibition, and improved gingival health.Feb 28, 2017

Mango polyphenols reduce IL-8, GRO, and GM-SCF plasma levels and increase lactobacillus species in patients with inflammatory bowel disease. Dec 31, 2019

These findings highlight the potential of pre-game mangiferin-quercetin supplementation to enhance intermittent high-intensity efforts in sports such as basketball.Jan 03, 2024

Mangiferin could ameliorate methylmercury mediated mitochondrial dysfunction in human hepatic cells in vitro.Jan 31, 2017

Alpha-mangostin alleviated HIF-1α-mediated angiogenesis in rats with adjuvant-induced arthritis.Dec 31, 2020