Mangosteen

Name	AC	CK
Inflammation	9	34
Oxidative Stress	10	21
Cervical Cancer	5	14
Athletic Performance	1	10
Breast Cancer	6	10
C-Reactive Protein	1	10
Elevated CRP	1	10
Gingivitis	1	10
High Fat Diet	5	10
Human Papillomavirus (HPV)	1	10
Obesity	6	10
Periodontitis	1	10
Alzheimer's Disease	7	9
Hyperglycemia	6	8
Arthritis	3	6
Brain Inflammation	4	6
Diabetes Mellitus: Type 2	4	6
Parkinson's Disease	4	6
Advanced Glycation End products (AGE)	4	5
Cancers: All	4	5
Diabetic Complications	4	5
Liver Damage	3	5
Staphylococcus aureus: Methicillin-resistant (MRSA)	3	5
Chemotherapy-Induced Toxicity	2	4
Chemotherapy-Induced Toxicity: Cisplatin	2	4
Kidney Damage	2	4
Lipopolysaccharide-Induced Toxicity	3	4
Metabolic Syndrome X	2	4
Ulcerative Colitis	2	4
Aging	2	3
Dengue	3	3
Hepatitis C	1	3
Hyperuricemia	1	3
Insulin Resistance	2	3
Kidney Fibrosis	1	3
Liver Cancer	2	3
Oral Cancer	3	3
Staphylococcus aureus infection	2	3
Acne	2	2
Autism	1	2
Autoimmune Diseases	1	2
Candida Albicans	2	2
Cerebral Hypoperfusion	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Colitis	1	2
Colon Cancer	1	2
Colorectal Cancer	2	2
Coronary Artery Disease	1	2
Dementia	1	2
Dermatitis	1	2
Diabetic Nephropathy	1	2
Dry Skin	1	2
Dysbiosis	1	2
Endothelial Dysfunction	1	2
Fatty Liver	1	2
Flukes	1	2
Gastric Ulcer	1	2
Hydrogen Peroxide Induced Toxicity	1	2
Malaria	1	2
Memory Disorders	1	2
Metabolic Diseases	1	2
Multiple Sclerosis	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Osteosarcoma	2	2
Pain	1	2
Pancreatic Cancer	1	2
Pancreatic Cancer: Metastatic	1	2
Parasitic Diseases	1	2
Psoriasis	1	2
Radiation	1	2
Skin Cancer	1	2
Systemic Lupus Erythematosus	1	2
Tumors	1	2
Wound Healing	1	2
Advanced Glycation Endproduct (AGE) Formation	1	1
Aging Skin	1	1
Arsenic Poisoning	1	1
Bacterial Infections	1	1
Bipolar Disorder	1	1
Brain: Oxidative Stress	1	1
Breast Cancer: Triple Negative	1	1
Cadmium Poisoning	1	1
Cancer Metastasis	1	1
Cancers: Multi-Drug Resistant	1	1
Chikungunya Virus	1	1
Coronavirus Disease (Covid-19)	1	1
Dengue Fever	1	1
Depression	1	1
Diabetes: Cognitive Dysfunction	1	1
Enterococcus Infections	1	1
Estrogen Dominance	1	1
Gastric Cancer	1	1
Glioblastoma	1	1
HIV Infections	1	1
Heart Hypertrophy	1	1
Infection: Antibiotic Resistant	1	1
Leukemia	1	1
Lung Cancer	1	1
Malignant Melanoma	1	1
Melanoma	1	1
Neurodegenerative Diseases	1	1
Promyelocytic leukemia	1	1
Prostate Cancer	1	1
Pulmonary Fibrosis: Bleomycin-Induced	1	1
Rotavirus Infections	1	1
Schizophrenia	1	1
Staphylococcal Infections	1	1
Streptococcus Infections	1	1

Name	AC	CK
Anti-Inflammatory Agents	34	96
Antioxidants	26	65
Antiproliferative	16	23
Apoptotic	15	23
Neuroprotective Agents	15	21
Tumor Necrosis Factor (TNF) Alpha Inhibitor	8	21
Renoprotective	8	18
Chemopreventive	5	15
Hepatoprotective	8	15
Interleukin-1 beta downregulation	3	13
Nrf2 activation	2	12
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	11
Gastrointestinal Agents	5	10
Matrix Metalloproteinase-8 Inhibitor	1	10
Postaglandin PGE2 downregulation	1	10
Antiviral Agents	7	9
Hypoglycemic Agents	6	9
Anti-Apoptotic	5	8
Alpha-amylase inhibitor	5	7
Anti-Bacterial Agents	4	6
Anti-metastatic	5	6
Interleukin-10 upregulation	3	6
Interleukin-6 Downregulation	4	6
Antimicrobial	5	5
Bcl-2 protein down-regulation	1	5
Cardioprotective	3	5
Cell cycle arrest	4	5
SIRT1 Activator	1	5
Anti-Fibrotic	2	4
Anticarcinogenic Agents	3	4
Gastroprotective	2	4
Immunomodulatory: Th17 downregulation	2	4
Interleukin-17 downregulation	2	4
NF-kappaB Inhibitor	3	4
Anti-Glycation Agents	3	3
Chemosensitizer	2	3
Interferon Gamma Reducer	2	3
Transforming growth factor beta (TGF-β) inhibitor	1	3
Uricosuric Agents	1	3
Alpha-glucosidase inhibitor	2	2
Analgesics	1	2
Anticholesteremic Agents	1	2
Antimalarials	1	2
Antiparasitic Agents	1	2
Autophagy Up-regulation	1	2
Catalase Up-Regulation	1	2
Chemoprotective Agents	1	2
Chemotherapeutic	2	2
Cyclooxygenase 2 Inhibitors	1	2
Glutathione Upregulation	1	2
Heme oxygenase-1 up-regulation	1	2
Hypolipidemic	1	2
Immunomodulatory	1	2
Immunosuppressive Agents	1	2
Interleukin-2 Downregulation	1	2
Interleukin-23 Downregulation	1	2
MicroRNA modulator	1	2
Nitric Oxide Enhancer	1	2
Nitric Oxide Inhibitor	2	2
PI3K/Akt/signaling suppression	1	2
Radioprotective	1	2
Superoxide Dismutase Up-regulation	1	2
Vasodilator Agents	1	2
Anti-Infective Agents	1	1
Antidepressive Agents	1	1
Aromatase Inhibitors	1	1
Cyclin D1 Down-Regulation	1	1
Enzyme Inhibitors	1	1
Enzyme Inhibitors: Pancreatic Lipase	1	1
Fatty Acid Synthesis Inhibitors	1	1
HIV Protease Inhibitors	1	1
Heme oxygenase-1 inducer	1	1
Histamine Antagonists	1	1
Malondialdehyde Down-regulation	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Multidrug Resistance Gene Modulators	1	1
Neurominidase Inhibitor	1	1
Photoprotective	1	1
Prostaglandin Antagonists	1	1

Additional Keywords : Plant Extracts

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Pubmed Data : Pak J Biol Sci. 2022 Jan ;25(9):843-851. PMID: 36098087

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These results demonstrate that intakes of mangosteen extracts reduces the glycation stress and results in the improvement of skin conditions.Jun 30, 2015

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Pubmed Data : J Clin Biochem Nutr. 2015 Jul ;57(1):27-32. Epub 2015 Apr 16. PMID: 26236097

Article Published Date : Jun 30, 2015

Study Type : Animal Study, In Vitro Study

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Substances : Mangosteen

Diseases : Advanced Glycation End products (AGE), Dry Skin

Additional Keywords : Plant Extracts

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These results suggest that Garcinia mangostana pericarp extract prevents cerebral inflammation in T2DM.Jun 30, 2021

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Pubmed Data : Mol Immunol. 2024 Jan 26. Epub 2024 Jan 26. PMID: 38280829

Article Published Date : Jan 25, 2024

Study Type : Animal Study

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Substances : Mangosteen

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents, Interleukin-17 downregulation

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α-mangostin suppressed the proliferation, migration, and invasion of pancreatic cancer cells.Dec 31, 2013

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Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:7548191. Epub 2022 Jan 17. PMID: 35082905

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

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Substances : Mangosteen

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

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Alpha-mangostin ameliorates bleomycin-induced pulmonary fibrosis.Dec 31, 2018

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Pubmed Data : Arch Virol. 2021 Jun ;166(6):1623-1632. Epub 2021 Mar 29. PMID: 33782775

Article Published Date : May 31, 2021

Study Type : In Vitro Study

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Substances : Mangosteen

Diseases : Dengue

Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Cytokine Storm

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Alpha-mangostin inhibits viral replication and suppresses nuclear factor kappa B (NF-κB)-mediated inflammation in dengue virus infection.Sep 26, 2022

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Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

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Substances : Mangosteen

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Chemopreventive

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Pubmed Data : Saudi J Biol Sci. 2021 Mar ;28(3):1615-1621. Epub 2020 Nov 24. PMID: 33732047

Article Published Date : Feb 28, 2021

Study Type : In Vitro Study

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Substances : Mangosteen

Diseases : Staphylococcus aureus infection

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation

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Isolated xanthones to inhibit protein oxidation, as indicated by the decreases in dityrosine and N'-formylkynurenine formation.Dec 31, 2016

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Pubmed Data : J Nat Med. 2017 Jan ;71(1):216-226. Epub 2016 Oct 13. PMID: 27738860

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Pubmed Data : Pharmaceuticals (Basel). 2022 Jan 11 ;15(1). Epub 2022 Jan 11. PMID: 35056141

Article Published Date : Jan 10, 2022

Study Type : In Vitro Study

Additional Links

Substances : Mangosteen

Diseases : Aging Skin, Oxidative Stress

Pharmacological Actions : Antioxidants, Photoprotective

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Mangosteen and Licorice contain compounds, alpha-mangostin and 18-beta-glyceryrrrhetinic acid, respectively, which confer resistance to rotavirus infection. Sep 01, 2006

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Pubmed Data : Virol J. 2006 Sep 1;3:68. PMID: 16948846

Article Published Date : Sep 01, 2006

Study Type : In Vitro Study

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Substances : Licorice, Mangosteen

Diseases : Rotavirus Infections

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Mangosteen and triphala had good antimicrobial action on the mono-species biofilm.Dec 31, 2021

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Pubmed Data : Eur Endod J. 2022 03 ;7(1):58-66. PMID: 35353063

Mangosteen extract has a protective effect against beta-amyloid-induced cytotoxicity, oxidative stress and altered protein expression in neurons.May 07, 2010

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Pubmed Data : J Proteome Res. 2010 May 7;9(5):2076-86. PMID: 20232907

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Pubmed Data : Int J Mol Sci. 2020 Aug 27 ;21(17). Epub 2020 Aug 27. PMID: 32867357

Article Published Date : Aug 26, 2020

Study Type : Review

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Substances : Mangosteen, Xanthones

Diseases : Alzheimer's Disease, Depression, Parkinson's Disease

Pharmacological Actions : Antidepressive Agents, Neuroprotective Agents

Additional Keywords : Plant Extracts

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Mangosteen pericarp could be an adjunctive treatment option for mood and psychotic disorders.Dec 31, 2018

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Pubmed Data : Front Psychiatry. 2019 ;10:115. Epub 2019 Mar 13. PMID: 30918489

Pubmed Data : Cell Stress Chaperones. 2020 Jan 2. Epub 2020 Jan 2. PMID: 31898286

Article Published Date : Jan 01, 2020

Study Type : In Vitro Study

Additional Links

Substances : Mangosteen

Diseases : Lung Cancer

Pharmacological Actions : Apoptotic, Chemotherapeutic

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α-mangostin synergistic activity with oxacillin against oxacillin-resistant staphylococcus saprophyticus.Aug 25, 2016

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Pubmed Data : BMC Microbiol. 2016 Aug 26 ;16(1):195. Epub 2016 Aug 26. PMID: 27566110

Mangosteen is a Sub of the following Topic

View the Evidence: 133 Abstracts with Mangosteen Research

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30-day ingestion of a mangosteen-rich energy drink increased the antioxidant capacity in human blood, and led to significant decrease in CRP levels. Jun 30, 2015

A functional beverage of mangosteen, aloe vera, green tea, and multivitamins enhances plasma antioxidant capacity in healthy adults.Dec 31, 2014

Combined extracts of Garcinia mangostana fruit rind and Cinnamomum tamala leaf supplementation enhances muscle strength and endurance in resistance trained males.Oct 21, 2018

Fermented mangosteen supplementation in the prevention of HPV-induced cervical cancer.Sep 26, 2022

Mangosteen has measurable antioxidant activity in human subjects. Oct 14, 2009

Mangosteen juice reduces biomarkers of inflammation, e.g. C-reactive protein, in obese subjects. Oct 20, 2009

The clinical effect of a propolis and mangosteen extract complex in subjects with gingivitis.Sep 04, 2024

α-mangostin may be used as food supplement or a potential therapeutic compound for breast cancer.Feb 17, 2016

α-mangostin may be useful for the development of alternative pharmacological strategies aimed at reducing the inflammatory process.Feb 18, 2016

Alpha-mangostin alleviate renal interstitial fibrosis.Nov 30, 2023

Alpha-mangostin, piperine and beta-sitosterol as hepatitis C antivirus.Aug 31, 2023

Hypouricemic actions of the pericarp of mangosteen in vitro and in vivo.Jan 26, 2023

Mangosteen metabolites as promising alpha-amylase inhibitor candidates.Dec 06, 2022

A compound in mangosteen prevents cisplatin-induced toxicity to the kidneys of rats.Oct 06, 2010

Alpha mangostin attenuated hepatic steatosis in high fat-diet fed rats potentially through enhanced cellular antioxidant capacity.Dec 31, 2015

Alpha-mangosteen lessens high-fat/high-glucose diet and low-dose streptozotocin induced-hepatic manifestations.Nov 30, 2023

Alpha-mangostin alleviated inflammation in rats with adjuvant-induced arthritis.Dec 31, 2020

Alpha-mangostin and resveratrol, dual-drugs-loaded mucoadhesive thiolated chitosan-based nanoparticles for synergistic activity against colon cancer cells.Dec 15, 2021

Alpha-mangostin improves endothelial dysfunction.Mar 13, 2021

Alpha-mangostin inhibits DMBA/TPA-induced skin cancer.Jul 31, 2017

Alpha-mangostin reduces the overactivation of the ERK signaling and also restored autism-like behavioral and neurochemical alterations.Feb 24, 2021

Alpha-mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders.Dec 05, 2019

Alphaα-mangostin Inhibited M1 polarization of macrophages/monocytes in antigen-induced arthritis.Dec 31, 2022

Cardioprotective effects of alpha-mangostin on doxorubicin-induced cardiotoxicity in rats.Dec 26, 2021

Ethanolic Garcinia mangostana extract and α-mangostin improve dextran sulfate sodium-induced ulcerative colitis.Jan 29, 2021

G. dulcis fruit rind could be a functional food to ameliorate symptoms of metabolic syndrome.Dec 30, 2019

G. mangostana is a promising alternative MRSA treatment because of its antibacterial, anti-inflammatory, and wound healing effects.Feb 28, 2019

G. mangostana extract possesses anti-inflammatory and antioxidant properties and can interfere with parasite development.Jun 30, 2015

Garcinia mangostana and α-mangostin revive ulcerative colitis-modified hepatic cytochrome P450 profiles.Dec 31, 2021

Garcinia mangostana pericarp extract showed promising in vivo antibacterial activity against MRSA.May 13, 2016

Impacts of the independent and synergistic effects of curcuma and mangosteen extracts on the gut bacterial composition in lean and obese rats.Feb 10, 2021

Isogarcinol has the potential to be an effective therapeutic agent of low toxicity for treating MS and other autoimmune diseases.Nov 29, 2016

Isogarcinol is a promising immunosuppressive agent for treating psoriasis.Jan 31, 2017

Isogarcinol may be a potential therapeutic drug candidate for future treatment of systemic lupus erythematosus.Sep 29, 2015

Mangiferin inhibits PDGF-BB-induced proliferation and migration of rat vascular smooth muscle cells and alleviates neointimal formation. Dec 31, 2020

Mangosteen contains compounds with anti-inflammatory and analgesic activity. Sep 01, 1998

Mangosteen ethanol extract alleviated the severity of collagen-induced arthritis in rats and produced synergistic effects with methotrexate.Nov 30, 2018

Mangosteen extract exerts anti-obesity effects by regulating energy metabolism and hepatic lipid homeostasis.Jan 31, 2016

Mangosteen flesh supplementation attenuates biochemical and morphological changes in the liver and kidney of high fat diet-induced obesity. Dec 01, 2019

Mangosteen hinders gamma radiation-mediated oxidative stress and liver injury.Mar 31, 2021

Mangosteen peel infusion has the potential to improve liver and kidney structure and functions after H2O2 induction.May 31, 2021

Mangosteen pericarp extract and curcuma were independently and in combination effective in treating obesity-induced inflammation.Nov 02, 2022

Mangosteen pericarp extract is a potential candidate for auxiliary therapy for Parkinson's disease.Dec 01, 2022

Mangosteen protects against cisplatin-induced kidney toxicity.Jan 01, 2009

Mangosteen vinegar rind could be a dietary aid for the prevention and management of diabetic nephropathy.Apr 30, 2019

Memory-enhancing effects of mangosteen pericarp water extract through antioxidative neuroprotection and anti-apoptotic action.Dec 29, 2020

Phenolics from Garcinia mangostana alleviate exaggerated vasoconstriction in metabolic syndrome.Sep 12, 2016

Protective effect of alpha mangostin on rotenone induced toxicity in rat model of Parkinson's disease.Jan 17, 2020

Rind from purple mangosteen attenuates diet-induced physiological and metabolic changes.Jan 21, 2021

Synergistic effects of α-mangostin and sorafenib in hepatocellular carcinoma.Jun 17, 2021

The combination of S. duplicatum and G. mangostana extracts improved the open wound healing process in diabetic mice.Dec 31, 2021

The pericarp of mangosteen contains compounds (xanthones) with anti-proliferative and cytotoxic activities. Oct 01, 2010

The protective effects of α-mangostin attenuate sodium iodate-induced cytotoxicity and oxidative injury.Nov 23, 2021

These results demonstrate that intakes of mangosteen extracts reduces the glycation stress and results in the improvement of skin conditions.Jun 30, 2015

These results suggest that Garcinia mangostana pericarp extract prevents cerebral inflammation in T2DM.Jun 30, 2021

Treatment efficacy of Thunbergia laurifolia, Curcuma longa, Garcinia mangostana, and Andrographis paniculata extracts in Staphylococcus aureus-induced dermatitis model.Dec 31, 2021

Xanthone could be a dietary supplement for the patient with diabetic complications.Dec 16, 2019

Xanthone-enriched fraction of Garcinia mangostana and α-mangostin improve the spatial learning and memory of chronic cerebral hypoperfusion.Oct 31, 2020

Xanthones reduced parasitemia by approximately 80% with a daily dose of 100 mg/kg administered twice a day for 7 days of treatment.Jul 31, 2015

α-mangostin derivatives ameliorated mouse DSS-induced chronic colitis.Jan 25, 2024

α-mangostin suppressed the proliferation, migration, and invasion of pancreatic cancer cells.Dec 31, 2013

α-Mangostin suppresses ethanol-induced gastric ulceration.Jan 29, 2024

Alpha-mangostin potentially possesses neuroprotective effects in a cellular model of Parkinson's disease.Dec 31, 2014

The purple mangosteen (Garcinia mangostana): Defining the anticancer potential of selected xanthones.Dec 08, 2021

A brief exposure to α-mangostin may suppress biofilm formation by targeting key enzymes imvolved in biofilm formation.Oct 31, 2015

A review on α-mangostin as a potential multi-target-directed ligand for Alzheimer's disease.Apr 14, 2021

Alpha mangostin derived from Garcinia magostana ameliorates cardiomyocyte hypertrophy and fibroblast phenotypes.Dec 31, 2020

Alpha-mangostin activates MOAP-1 tumor suppressor and mitochondrial signaling in MCF-7 human breast cancer cells. Dec 31, 2021

Alpha-mangostin ameliorates bleomycin-induced pulmonary fibrosis.Dec 31, 2018

Alpha-mangostin has great potential to be further developed into a promising modulator of ABCG2 for reversing multidrug resistance.Jun 21, 2017

Alpha-mangostin induces apoptosis in human osteosarcoma cells.Dec 31, 2020

Alpha-mangostin inhibits dengue virus production and pro-inflammatory cytokine/chemokine expression in dendritic cells.May 31, 2021

Mangosteen

View the Evidence:
133 Abstracts with Mangosteen Research