Medicinal Mushrooms

Name	AC	CK
Cancers: All	39	132
Breast Cancer	47	75
Inflammation	32	71
Diabetes Mellitus: Type 2	35	70
Oxidative Stress	33	61
Lung Cancer	28	54
Liver Cancer	21	53
Colon Cancer	24	40
Prostate Cancer	16	36
Breast Cancer: Triple Negative	16	29
Diabetes Mellitus: Type 1	8	28
Fatigue	6	28
Alzheimer's Disease	15	27
Chemically-Induced Liver Damage	15	27
Atherosclerosis	9	26
Cancer Metastasis	9	26
Lipopolysaccharide-Induced Toxicity	19	25
Obesity	10	25
Cervical Cancer	10	24
Cognitive Decline/Dysfunction	4	24
Depression	9	23
Hepatitis B	4	22
Hyperlipidemia	11	21
Insulin Resistance	7	21
Gastric Cancer	15	20
Herpes Zoster	2	20
High Fat Diet	10	20
Hydrogen Peroxide Induced Toxicity	10	20
Osteopenia	1	20
Shingles	2	20
Bladder Cancer	8	19
Chemotherapy-Induced Toxicity	6	19
Chemotherapy-Induced Toxicity: Cisplatin	11	19
Dementia	6	19
Colorectal Cancer	12	18
DNA damage	7	18
Radiation Induced Illness	4	18
Aging	11	17
Colitis	8	17
Alcohol Toxicity	9	16
Hyperglycemia	11	16
Parkinson's Disease	9	15
Hypercholesterolemia	7	14
Lipid Peroxidation	5	14
Melanoma	8	14
Neurodegenerative Diseases	9	14
Asthma	3	13
Leukemia	12	13
Diabetic Complications	6	12
Endothelial Dysfunction	2	12
Gastric Ulcer	7	12
Glioma	6	12
Inflammatory Bowel Diseases	6	12
Ovarian Cancer	3	12
Anxiety Disorders	2	11
Carcinoma: Non-Small-Cell Lung	9	11
Diabetes: Cardiovascular Illness	2	11
High Cholesterol	6	11
Osteoporosis	4	11
Prostatic Hyperplasia: Benign	2	11
Tumors	6	11
Upper Respiratory Infections	2	11
Breast Cancer: Prevention	1	10
C-Reactive Protein	1	10
COPD	1	10
Chemotherapy-Induced Toxicity: Doxorubicin	6	10
Cold Sore	1	10
Depressive Disorder	1	10
Endometrial Cancer	1	10
Focal segmental glomerulosclerosis (FSGS)	1	10
HSV-2	1	10
Herpes Genitalis	1	10
Kidney Diseases	1	10
Kidney Failure	1	10
Lupus Nephritis	1	10
Myelodysplastic Syndromes	1	10
Organ Transplantation: Kidney	1	10
Overweight	1	10
Post-Herpetic Neuralgia	1	10
Quality of Life: Poor	1	10
Sleep Disorders	1	10
Weight Probems: Appetite	1	10
Allergies	4	9
Brain Inflammation	6	9
Coronavirus Infection	5	9
Diabetic Nephropathy	5	9
Dyslipidemias	5	9
HIV Infections	9	9
Immune Disorders: Low Immune Function	5	9
Influenza	5	9
Cadmium Poisoning	4	8
Cerebral Ischemia	4	8
Chemotherapy-Induced Toxicity: Cyclophosphamide	3	8
Immune Dysregulation: TH1/TH2 imbalance	5	8
Influenza A	5	8
Kidney Fibrosis	5	8
Liver Cirrhosis	4	8
Liver Damage: Drug-Induced	3	8
Lymphoma	6	8
Memory Disorders	4	8
Hepatitis C	5	7
Ultraviolet Radiation Induced Damage	5	7
Acetaminophen (Tylenol) Toxicity	3	6
Anxiety	4	6
Breast Cancer: Metastatic	3	6
Chemotherapy and Radiation Toxicity	3	6
Epilepsy	4	6
Kidney Cancer	4	6
Klebsiella Infections	3	6
Myelotoxicity	3	6
Pancreatitis	3	6
Pseudomonas aeruginosa	6	6
Sepsis	3	6
Toxoplasma gondii Infection	3	6
Wound Healing	3	6
Brain: Oxidative Stress	4	5
Chemotherapy-Induced Kidney Damage	3	5
Cholangiocarcinoma	1	5
Chronic Kidney Disease (CKD)	3	5
Crohn's Disease	1	5
Dengue	3	5
Dysbiosis	2	5
Esophageal Cancer	3	5
H1N1 Infection	3	5
Hepatic Steatosis	3	5
Multiple Myeloma	4	5
Triglycerides: Elevated	3	5
Acute Myeloid Leukemia	3	4
Aging: Brain	2	4
Arteriosclerosis	2	4
Arthritis	1	4
Atopic Dermatitis	2	4
Cancers: Multi-Drug Resistant	3	4
Candida Albicans	3	4
Cardiovascular Diseases	3	4
Chemotherapy Induced Myelotoxicity	2	4
Chemotherapy-Induced Toxicity: 5-fluorouracil	2	4
Chemotherapy-Induced Toxicity: Bleomycin	2	4
Coronavirus Disease	2	4
Epstein-Barr Virus Infections	3	4
Fatty Liver	2	4
Food Allergies	2	4
Gastrointestinal Inflammation	2	4
Glioblastoma	1	4
Hair Loss	2	4
Herpes Simplex Virus Type 1	4	4
High Cholesterol: very low density lipoprotein (VLDL)	2	4
Hypertension	2	4
Hypoglycemia	2	4
Hypoxia	3	4
Infertility: Male	2	4
Liver Disease	2	4
Low Immune Function: Natural Killer Cells	2	4
Nonalcoholic fatty liver disease (NAFLD)	2	4
Peripheral Nerve Diseases	2	4
Skin Cancer	2	4
Staphylococcus aureus infection	4	4
Staphylococcus epidermidis	3	4
Bacillus subtilis infections	2	3
Cardiomyopathy	2	3
Diabetes: Oxidative Stress	2	3
Gastrointestinal Diseases	2	3
Helicobacter Pylori Infection	2	3
Ischemia	2	3
Laryngeal Cancer	1	3
Neutropenia: Chemotherapy Induced	3	3
Organ Transplantation	2	3
Osteosarcoma	3	3
Pancreatic Cancer	3	3
Sarcoidosis	1	3
Acrylamide-induced toxicity	1	2
Aging Skin	1	2
Alcoholic Liver Disease	1	2
Aluminum Toxicity	1	2
Amyloid toxicity	1	2
Amyloid β peptide toxicity	1	2
Anaphylactic Reaction	1	2
Androgen-Induced Diseases	2	2
Animal Cancers	1	2
Arrhythmias: Cardiac	1	2
Asthma: Bronchial	1	2
Autoimmune Diseases	1	2
Brain: Microglial Activation	1	2
Breast Cancer: Drug Resistant	2	2
Breast Cancer: Inflammatory	1	2
Bronchitis	1	2
Cachexia	1	2
Candidiasis	1	2
Cat Diseases	1	2
Cataract	1	2
Chemotherapy-Induced Toxicity: Mitomycin-C	1	2
Chemotherapy-Induced Toxicity: Paclitaxel	1	2
Chronic Myeloid Leukemia	2	2
Chronic Obstructive Pulmonary Disease	1	2
Chronic Pain	1	2
Citrobacter Infection	1	2
Colon Cancer: Prevention	1	2
Coronary Artery Disease	1	2
Coxsackievirus Infections	1	2
Cysts	1	2
Depression	1	2
Dermatitis: Contact	1	2
Diabetic Neuropathy	1	2
Duodenal Ulcer	1	2
Dysthymic Disorder	1	2
End Stage Renal Disease	1	2
Enterobacteriaceae Infections	1	2
Enterococcus Infections	1	2
Escherichia coli Infections	2	2
Fatigue: Excercise-Induced	1	2
Female	1	2
Formaldehyde Toxicity	1	2
Gastric Ulcers	1	2
H3N2 Infection	1	2
H5N1 Infection	1	2
HSV-1	1	2
Hepatoma	2	2
High Sugar Diet	1	2
Histamine: Elevated	1	2
Human Flu	1	2
Human Influenza	1	2
Hyperinsulinism	1	2
Hypertension: Portal	1	2
Hyperuricemia	1	2
Irritable Bowel Syndrome	1	2
Ischemia: Myocardial	1	2
Kidney Failure: Chronic	1	2
Lead Poisoning	1	2
Learning disorders	1	2
Leukemia: Monocytic	2	2
Lipid Metabolism: Abnormalities	1	2
Listeria Infections	1	2
Liver Cancer: Prevention	1	2
Liver Damage	1	2
Liver Fibrosis	1	2
Liver Injury: Ischemia/reperfusion	1	2
Liver Steatosis	1	2
Low Immune Function: Splenic Dysfunction	1	2
Low Immune Function: Thymus Dysfunction	1	2
Low Libido	1	2
Lung Damage	1	2
Lupus Erythematosus: Systemic	1	2
Malaria	1	2
Mental Fatigue	1	2
Metabolic Syndrome X	1	2
Multi-Organ Failure	1	2
Mycobacterium tuberculosis	1	2
Myocardial Ischemia	1	2
Neurologic Disorders	2	2
Neuropathic Pain	1	2
Neutropenia	2	2
Neutropenia: Cyclic	2	2
Organ Transplantation: Skin	1	2
Pancreatitis: Chronic	1	2
Polycystic Kidney Diseases	1	2
Prediabetes	1	2
Progesterone: Low	1	2
Promyelocytic leukemia	2	2
Pulmonary Cancer	1	2
Pulmonary Fibrosis	1	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Radiation Induced Illness: Enteritis	1	2
Respiratory Infections	1	2
Rhinovirus Infection	1	2
Schistosomiasis	1	2
Sexual Arousal Disorder	1	2
Sexual Dysfunction	1	2
Stomach Cancer	2	2
Streptococcus Infections	1	2
Streptococcus infections: Group A	1	2
Stress	1	2
Swine Flu Associated Virus	1	2
Systemic Lupus Erythematosus	1	2
Testicular Cancer	1	2
Testicular Injury: Cadmium-Induced	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Thrombosis	2	2
Thymic Dysplasia	1	2
Toxoplasmosis	1	2
Ulcerative Colitis	1	2
Urolithiasis	1	2
Water Retention	1	2
West Nile Fever	1	2
Adrenal Gland Diseases	1	1
Adrenal Gland: Enhanced Apoptosis	1	1
Arthritis: Rheumatoid	2	1
Aspergillosis	1	1
Bacterial Infections	1	1
Bacterial Infections and Mycoses	1	1
Brain Hypoxia	1	1
Breast Cancer: Lung Metastasis	1	1
Cancers: Canine	1	1
Cancers: Drug Resistant	1	1
Carcinoma: Small Cell Lung	1	1
Chemotherapy	1	1
Chronic Lymphocytic Leukemia	1	1
Clotting	1	1
Cryptococcosis	1	1
Cystic Fibrosis	1	1
Demyelinating Diseases	1	1
Dry Skin	1	1
Endotoxemia	1	1
Enterovirus 71	1	1
Epithelial Neoplasms: Malignant	1	1
Fungal Infection	1	1
Gram-Negative Bacterial Infections	1	1
Gram-Positive Bacterial Infections	1	1
Hepatoma: Multidrug Resistant	1	1
Herpes Simplex Virus Type 2	1	1
Infant Acute Monocytic Leukemia	1	1
Larynx Neoplasms	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Leukopenia: Chemotherapy Induced	1	1
Malignant Melanoma	1	1
Melanoma: Metastatic	1	1
Metabolic Diseases	1	1
Micrococcus luteus infections	1	1
Mycotoxin Toxicity	1	1
Neurological Conditions	1	1
Neutropenia: Severe Congenital	1	1
Oral Cancer	1	1
Parasitic Diseases	1	1
Phthalate Toxicity	1	1
Pigmentation Disorders	1	1
Pulmonary Hypertension	1	1
Radiation Disaster Associated Toxicity	1	1
Sarcoma	1	1
Squamous cell carcinoma	1	1
Stroke	1	1
Testosterone-Induced	1	1
Tuberculosis	1	1
Vitamin B 12 Deficiency	1	1
Vitamin D Deficiency	1	1

Name	AC	CK
Antioxidants	139	265
Anti-Inflammatory Agents	102	207
Immunomodulatory	78	183
Antiproliferative	107	170
Apoptotic	101	155
Chemotherapeutic	23	90
Neuroprotective Agents	50	88
Hypoglycemic Agents	43	82
Hepatoprotective	40	81
Tumor Necrosis Factor (TNF) Alpha Inhibitor	38	68
Chemopreventive	22	61
Anti-Apoptotic	30	56
Gastrointestinal Agents	19	56
Hypolipidemic	30	56
NF-kappaB Inhibitor	34	55
Cell cycle arrest	36	54
Antineoplastic Agents	29	50
Immunostimulatory	18	49
Anti-metastatic	25	45
Interleukin-6 Downregulation	21	41
Interleukin-1 beta downregulation	22	40
Antiviral Agents	29	39
Antidepressive Agents	10	34
Cyclooxygenase 2 Inhibitors	19	34
Osteoprotective	5	31
Renoprotective	18	31
Antifungal Agents	7	27
Chemoprotective Agents	15	26
Malondialdehyde Down-regulation	14	25
Cardioprotective	14	23
Anti-Bacterial Agents	17	22
Superoxide Dismutase Up-regulation	10	18
Analgesics	5	17
Gastroprotective	10	17
Anti-Anxiety Agents	5	16
Interleukin-10 upregulation	4	16
Autophagy Up-regulation	8	15
Bcl-2 protein down-regulation	8	15
Cytotoxic	12	15
Anticholesteremic Agents	8	14
Nitric Oxide Inhibitor	6	14
Nrf2 activation	10	14
Neuritogenic	9	13
Brain-derived neurotrophic factor modulator	2	12
Interferon-gamma (IFN-gamma) inducer	2	12
Alpha-glucosidase inhibitor	9	11
Chemosensitizer	8	11
Matrix metalloproteinase-9 (MMP-9) inhibitor	7	11
Anticarcinogenic Agents	5	10
Anxiolytic	1	10
Interleukin-4 upregulation	1	10
Cyclin D1 Down-Regulation	4	9
Genoprotective	4	9
Radioprotective	4	9
Anti-Allergic Agents	3	7
Anti-Tumor	4	7
Anti-Ulcer Agents	4	7
Antihypertensive Agents	5	7
Antimutagenic Agents	3	7
Caspase-3 Activation	4	7
P21 Activation	3	7
Pancreato Protective Agents	5	7
Tumor Suppressor Protein p53 Upregulation	7	7
Anti-Fibrotic	4	6
Anti-atherogenic	3	6
Heme oxygenase-1 up-regulation	4	6
Interleukin-12 upregulation	4	6
Osteogenic	1	6
Antinoceceptive	3	5
Antiparasitic Agents	3	5
Caspase-9 Activation	3	5
MicroRNA modulator	4	5
Photoprotective	4	5
Prophylactic Agents	3	5
Angiogenesis Inhibitors	2	4
Anti-Angiogenic	3	4
Anti-HIV Agents	4	4
Aromatase Inhibitors	3	4
Catalase Up-Regulation	2	4
Enzyme Inhibitors	2	4
Glutathione Upregulation	2	4
Interleukin-4 downregulation	2	4
Neurogenesis	2	4
Radiation-Protective Agents	2	4
Alpha-amylase inhibitor	3	3
Antimicrobial	3	3
Immunosuppressive Agents	2	3
Insulin Sensitizers	2	3
Interferon Gamma Reducer	2	3
Matrix metalloproteinase-1 (MMP-1) inhibitor	2	3
Neurominidase Inhibitor	2	3
Tumor Necrosis Factor (TNF) Alpha Enhancer	2	3
Wnt/β-catenin signaling pathway modulation	3	3
5-Lipoxygenase Inhibitor	1	2
5-alpha reductase inhibitor	2	2
Acetylcholinesterase Inhibitor	2	2
Anticonvulsants	1	2
Aphrodisiac	1	2
Bax/Bcl2 ratio: Increase	1	2
Bcl-xL down-regulation	1	2
Caspase-8 activation	1	2
Cytoprotective	1	2
DNA Repair Up-regulation	1	2
Detoxifier	1	2
Diuretics	1	2
Heat Shock Protein Down-Regulation	1	2
Hematopoietic	2	2
Immunomodulatory: Th17 downregulation	1	2
Interleukin-1 beta upregulation	1	2
Interleukin-2 Downregulation	1	2
Interleukin-6 upregulation	1	2
Lactate Dehydrogenase A Inhibitor	1	2
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	2
Nitric Oxide Enhancer	2	2
Platelet Aggregation Inhibitors	2	2
Protein tyrosine phosphatase 1B (PTP1B) modulator	1	2
Radiosensitizer	2	2
Regenerative	1	2
Secretagogue	1	2
Telomerase Inhibitor	2	2
Topoisomerase I inhibitor	1	2
Topoisomerase II Inhibitor	1	2
Uricosuric Agents	1	2
Vascular Endothelial Growth Factor Inhibitors	1	2
interleukin-13 down-regulation	1	2
Angiotensin-Converting Enzyme Inhibitors	1	1
Anti-Infective Agents	1	1
Anti-Platelet	1	1
Antimycobacterial	1	1
Autophagy Inhibitors	1	1
Cyclooxygenase Inhibitors	1	1
Estrogen Receptor Modulators	1	1
Gene Protective	1	1
HIV Protease Inhibitors	1	1
Hypnotics and Sedatives	1	1
Interferon Inducers	1	1
Interleukin-10 downregulation	1	1
Interleukin-18 down-regulation	1	1
Interleukin-18 upregulation	1	1
Interleukin-8 downregulation	1	1
Matrix Metalloproteinase-7 (MMP-7) Inhibitor	1	1
Monoamine Oxidase Inhibitors	1	1
Multidrug Resistance Gene Modulators	1	1
Platelet aggregation inhibitor: collagen-induced aggregation	1	1
Postaglandin PGE2 downregulation	1	1
Prostaglandin PGE2 downregulation	1	1
Quorum Sensing Inhibition	1	1
Reactive Oxygen Species (ROS) attenuation	1	1
Reverse Transcriptase Inhibitors	1	1
STAT3 Inhibitor	1	1
Tyrosinase inhibitors	1	1
Vasoprotective	1	1
Wnt/β-catenin pathway down-regulation	1	1

Pubmed Data : Am J Chin Med. 2005;33(4):517-23. PMID: 16173526

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Substances : Reishi Mushroom

Diseases : Herpes Zoster, Shingles

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A phase I/II trial of a polysaccharide extract from Maitake mushroom in breast cancer patients.Aug 31, 2009

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Cancer Res Clin Oncol. 2009 Sep ;135(9):1215-21. Epub 2009 Mar 1. PMID: 19253021

Article Published Date : Aug 31, 2009

Study Type : Human Study

Additional Links

Substances : Maitake Mushroom

Diseases : Breast Cancer

Pharmacological Actions : Immunomodulatory, Immunostimulatory

Additional Keywords : Polysaccharides

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Agaricus blazei extract in combination with metformin and gliclazide improve insulin resistance in type 2 diabetics. Dec 01, 1999

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Pubmed Data : J Surg Oncol. 1999 Dec;72(4):230-9. PMID: 17309383

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Foods. 2021 Jul 5 ;10(7). Epub 2021 Jul 5. PMID: 34359426

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Indian Heart J. 2018 Sep - Oct;70(5):608-614. Epub 2017 Dec 14. PMID: 30392496

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Pubmed Data : Int J Cancer. 2009 Mar 15;124(6):1404-8. PMID: 19048616

Article Published Date : Mar 15, 2009

Study Type : Human Study

Additional Links

Substances : Green Tea, Mushrooms: All

Diseases : Breast Cancer: Prevention, Cancer Metastasis

Pharmacological Actions : Chemopreventive

Additional Keywords : Risk Reduction

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Dongchongxiacao (Cordyceps) can reduce serum markers of airway inflammation of asthmatics.Sep 01, 2005

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Pubmed Data : J Hypertens. 2005 Sep;23(9):1699-706. PMID: 17972591

Article Published Date : Sep 01, 2005

Study Type : Human Study

Additional Links

Substances : Cordyceps sinensis

Diseases : Asthma, COPD

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Effect of supplemental antioxidant-based therapy on the oxidative stress level in COVID-19 patients.Feb 28, 2023

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Pubmed Data : Food Funct. 2021 Feb 1. Epub 2021 Feb 1. PMID: 33521800

Article Published Date : Jan 31, 2021

Study Type : Human In Vitro, Human Study

Additional Links

Substances : Fermented Foods and Beverages, Oyster Mushroom, Reishi Mushroom

Diseases : Osteopenia

Pharmacological Actions : Gastrointestinal Agents, Osteoprotective

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Habitual mushroom intake might help to prevent prostate cancer.Sep 03, 2019

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Pubmed Data : Int J Cancer. 2019 Sep 4. Epub 2019 Sep 4. PMID: 31486077

Article Published Date : Sep 03, 2019

Study Type : Human Study

Additional Links

Substances : Mushrooms: All

Diseases : Prostate Cancer

Pharmacological Actions : Chemopreventive

Additional Keywords : Risk Reduction

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Hericium erinaceus improves mood and sleep disorders in patients affected by overweight or obesity.Dec 31, 2018

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Pubmed Data : J Altern Complement Med. 2010 Dec ;16(12):1295-9. Epub 2010 Oct 29. PMID: 21034160

Article Published Date : Nov 30, 2010

Study Type : Human Study

Additional Links

Substances : Maitake Mushroom

Diseases : Insulin Resistance, Polycystic Ovary Syndrome

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Mushroom mycelium extract was an ineffective treatment for reducing 50% or more the patient prostate specific antigen values.Sep 30, 2010

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Pubmed Data : Pharmacol Res. 2022 Jan ;175:105979. Epub 2021 Nov 16. PMID: 34798266

Article Published Date : Dec 31, 2021

Study Type : Human Study

Additional Links

Substances : King trumpet mushroom

Diseases : Obesity

Pharmacological Actions : Appetite Depressants

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Prevention of early Alzheimer's disease by Erinacine A-enriched Hericium erinaceus mycelia.Dec 31, 2019

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Pubmed Data : Front Aging Neurosci. 2020 ;12:155. Epub 2020 Jun 3. PMID: 32581767

Article Published Date : Dec 31, 2019

Study Type : Human Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus)

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

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Regular shiitake mushroom consumption resulted in improved immunity.Dec 31, 2014

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Pubmed Data : J Am Coll Nutr. 2015 ;34(6):478-87. Epub 2015 Apr 11. PMID: 25866155

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Pubmed Data : Psychiatry Res. 2015 Jul 15. Epub 2015 Jul 15. PMID: 26208984

Pubmed Data : Int J Med Mushrooms. 2018 ;20(8):705-716. PMID: 30317947

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Substances : Beta-glucan, Reishi Mushroom, Yoghurt

Pharmacological Actions : Immunomodulatory

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Triterpene ganoderic acid inhibited production of TNF-α and other proinflammatory cytokines by PBMCs and inflamed CD colonic mucosa due to blockage of NF-κB activation.May 18, 2015

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Pubmed Data : Inflamm Bowel Dis. 2015 May 19. Epub 2015 May 19. PMID: 25993687

Article Published Date : May 18, 2015

Study Type : Human In Vitro

Additional Links

Substances : Reishi Mushroom

Diseases : Crohn's Disease

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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verticillin A from Verticillium-infected wild mushrooms as a potent anti-cancer agent that effectively suppresses 5-FU-resistant human colon cancer cells. Aug 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Lipid-lowering effects of Inonotus obliquus polysaccharide.Dec 11, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Foods. 2021 Dec 12 ;10(12). Epub 2021 Dec 12. PMID: 34945636

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Ganoderma lucidum polysaccharides protect against sepsis-induced cardiac dysfunction by activating SIRT1.Sep 23, 2021

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Pubmed Data : J Pharm Pharmacol. 2021 Sep 24. Epub 2021 Sep 24. PMID: 34559876

Article Published Date : Sep 23, 2021

Study Type : Animal Study

Additional Links

Substances : Reishi Mushroom

Diseases : Sepsis

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, SIRT1 Activator, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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16α-hydroxytrametenolic acid from Poria cocos improves intestinal barrier function.Oct 01, 2019

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Pubmed Data : J Agric Food Chem. 2019 Oct 2 ;67(39):10871-10879. Epub 2019 Sep 23. PMID: 31517482

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Pubmed Data : J Sci Food Agric. 2010 Jan 30 ;90(2):276-80. PMID: 20355042

Article Published Date : Jan 29, 2010

Study Type : Animal Study

Additional Links

Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Diabetes Mellitus: Type 2, Hyperglycemia

Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Malondialdehyde Down-regulation

Additional Keywords : Plant Extracts

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A fungal protein from H. erinaceus could be used as a drug or functional food ingredient for immunotherapy.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Immunol. 2017 ;8:666. Epub 2017 Jun 12. PMID: 28713364

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Pubmed Data : Int J Med Mushrooms. 2015 ;17(11):1055-60. PMID: 26853960

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus)

Diseases : Gastric Ulcer

Pharmacological Actions : Anti-Ulcer Agents

Additional Keywords : Plant Extracts

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A polysaccharide from Inonotus obliquus ameliorates intestinal barrier dysfunction in mice with type 2 diabetes mellitus.Jun 13, 2022

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Pubmed Data : Int J Biol Macromol. 2022 Jun 14. Epub 2022 Jun 14. PMID: 35714869

Article Published Date : Jun 13, 2022

Study Type : Animal Study

Additional Links

Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Gastroprotective

Additional Keywords : Polysaccharides

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A polysaccharide from Pleurotus nebrodensis might be a promising candidate for preventing hepatic I/R injury.Nov 30, 2017

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Pubmed Data : Int J Biol Macromol. 2017 Dec ;105(Pt 1):447-451. Epub 2017 Jul 11. PMID: 28709897

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Pubmed Data : Oncol Rep. 2006 Dec;16(6):1181-7. PMID: 17089035

Article Published Date : Dec 01, 2006

Study Type : Animal Study

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Substances : Reishi Mushroom

Diseases : Lung Cancer, Pulmonary Cancer

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A water-soluble polysaccharide from chaga mushroom had potential as a natural antitumor agent with immunomodulatory activity.Sep 30, 2012

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Pubmed Data : Carbohydr Polym. 2012 Oct 1 ;90(2):870-4. Epub 2012 Jun 17. PMID: 22840014

Article Published Date : Sep 30, 2012

Study Type : Animal Study

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Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Gastric Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Immunomodulatory

Additional Keywords : Plant Extracts

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A white button mushroom extract acted as a potent dietary antioxidant and protects against Al-mediated neurotoxicity, by abrogating neuronal oxidative stress.Aug 31, 2014

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Pubmed Data : Pak J Biol Sci. 2014 Sep ;17(9):1079-82. PMID: 26031030

Article Published Date : Aug 31, 2014

Pubmed Data : J Exp Ther Oncol. 2009;8(1):43-51. PMID: 19827270

Article Published Date : Jan 01, 2009

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Pubmed Data : Life Sci. 2006 May 30 ;79(1):72-80. Epub 2006 Feb 3. PMID: 16458328

Article Published Date : May 29, 2006

Study Type : Animal Study

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Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Melanoma

Pharmacological Actions : Immunostimulatory

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Bachu mushroom polysaccharide alleviates colonic injury by modulating the gut microbiota.Dec 31, 2021

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Pubmed Data : Comput Math Methods Med. 2022 ;2022:1353724. Epub 2022 Mar 14. PMID: 35371288

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Pubmed Data : Molecules. 2014 ;19(9):14383-95. Epub 2014 Sep 12. PMID: 25221864

Article Published Date : Dec 31, 2013

Study Type : Animal Study, In Vitro Study

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Substances : Antrodia camphorata, Chaga Mushroom (Inonotus obliquus), Phellinus Linteus, Reishi Mushroom

Diseases : Melanoma

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Cyclin D1 Down-Regulation, P21 Activation

Additional Keywords : Plant Extracts, Superiority of Natural Substances versus Drugs

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Chaga mushroom and its compounds could be used as natural anticancer ingredients.May 31, 2010

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Pubmed Data : Nutr Res Pract. 2010 Jun ;4(3):177-82. Epub 2010 Jun 29. PMID: 20607061

Article Published Date : May 31, 2010

Study Type : Animal Study, In Vitro Study

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Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Breast Cancer, Carcinoma: Non-Small-Cell Lung, Cervical Cancer, Gastric Cancer

Pharmacological Actions : Antiproliferative

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Chaga mushroom extract significantly reduced the total IgE levels in mice and slightly affected the production of IgG1.Mar 31, 2013

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Pubmed Data : Int Immunopharmacol. 2013 Apr ;15(4):666-70. Epub 2013 Mar 25. PMID: 23535020

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Pubmed Data : Heliyon. 2016 May ;2(5):e00111. Epub 2016 May 12. PMID: 27441282

Article Published Date : Apr 30, 2016

Study Type : Animal Study, In Vitro Study

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Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Chemopreventive

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Cordycepin mitigates MPTP-induced Parkinson's disease through inhibiting TLR/NF-κB signaling pathway.Feb 17, 2019

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Pubmed Data : Life Sci. 2019 Feb 18. Epub 2019 Feb 18. PMID: 30790609

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Pubmed Data : Front Pharmacol. 2021 ;12:801094. Epub 2022 Feb 10. PMID: 35222012

Article Published Date : Dec 31, 2020

Study Type : Animal Study

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Substances : Medicinal Mushrooms

Diseases : Hypertension, Kidney Damage, Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, Renoprotective

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Cordyceps cicadae extracts ameliorate renal malfunction in a remnant kidney model.Nov 30, 2011

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Pubmed Data : Mol Chem Neuropathol. 1998 Feb;33(2):139-48. PMID: 16014434

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Pubmed Data : Nutr Cancer. 2008 Mar-Apr;60(2):227-34. PMID: 19051352

Article Published Date : Mar 01, 2008

Study Type : Animal Study

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Substances : Cordyceps sinensis

Diseases : Infertility: Male

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Cordyceps suppresses the expression of diabetes regulating genes by inhibiting lipopolysaccharide-induced inflammation in macrophages. Jun 01, 2009

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Pubmed Data : Immune Netw. 2009 Jun;9(3):98-105. Epub 2009 Jun 30. PMID: 20107539

Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis.Dec 31, 2020

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Pubmed Data : PLoS One. 2021 ;16(11):e0259570. Epub 2021 Nov 5. PMID: 34739514

Article Published Date : Dec 31, 2020

Study Type : Animal Study

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Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Endometritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Polysaccharides

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Effect of Pleurotus fossulatus aqueous extract on biochemical properties of liver and kidney in streptozotocin-induced diabetic rat.Dec 31, 2019

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Pubmed Data : Biomed Res Int. 2022 ;2022:4314415. Epub 2022 Mar 8. PMID: 35299891

Article Published Date : Dec 31, 2021

Study Type : Animal Study

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Substances : Reishi Mushroom

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Autophagy Up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Polysaccharides

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Effects of Agaricus blazei Murrill polysaccharides on hyperlipidemic rats by regulation of intestinal microflora.May 31, 2020

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View the Evidence: 1163 Abstracts with Medicinal Mushrooms Research

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Benefits of herbal formulae containing Poria cocos for type 2 diabetes mellitus.Dec 31, 2021

Antitumor activities of Grifola frondosa polysaccharide.Jul 12, 2021

C. versicolor and G. lucidum related natural products might have potential benefits on the overall survival and quality of life in cancer patients.Dec 31, 2018

Meta-analysis on effect of Grifola frondosa polysaccharide in regulating in vivo immunoregulatory function.Nov 30, 2019

S. crispa extracts are useful for prevention and treatment of human diseases.May 15, 2018

A study of facial wrinkles improvement effect of veratric acid from cauliflower mushroom.Mar 31, 2016

A combination of geranium extract, Ganoderma lucidum, Codonopsis pilosula and Angelicae sinensis, improve the condition of cancer patients receiving chemotherapy/radiotherapy. Jun 01, 2009

A combined treatment of Lentinula edodes mycelia and immunotherapy might improve QOL and immunological function in cancer patients.Jun 30, 2016

A dietary supplement with Agaricus sylvaticus fungus is capable of improving the life quality of patients with colorectal cancer in post-surgical phase.Dec 31, 2009

A maitake mushroom extract has beneficial immunomodulatory potential in patients with myelodysplastic syndromes.Oct 28, 2014

A mushroom formula containing Reishi (Ganoderma) has therapeutic activity against herpes genitalis and labialis.Nov 01, 2007

A mushroom formula containing Reishi (Ganoderma) reduces pain in patients with Herpes zoster.Jan 01, 2005

A phase I/II trial of a polysaccharide extract from Maitake mushroom in breast cancer patients.Aug 31, 2009

Agaricus blazei extract in combination with metformin and gliclazide improve insulin resistance in type 2 diabetics. Dec 01, 1999

Agaricus blazei extract normalizes liver function in patients with chronic hepaititis B. Apr 01, 2008

Agaricus blazei increases natural killer cell activity and quality of life in gynecological cancer patients undergoing chemotherapy. Jul 01, 2004

Agaricus brasiliensis has a wide range of therapeutic properties as demonstrated in mice and human subjects. Jun 01, 2008

AGM possibly improves insulin sensitivity and β-cell function and reduces liver damage and inflammation in prediabetic adults.Jul 04, 2021

AHCC improves prognosis of postoperative liver cancer patients. Jul 01, 2002

AHCC may improve survival and prognosis in patients with advanced liver cancer. Mar 01, 2006

Beta glucan found in reishi mushroom is a potent antioxidant against pathogenesis of atherosclerosis in stable angina and high risk patients.Oct 01, 2018

Combined therapy of Red sage (S. miltiorrhizae) and Zhu Ling (P. umbellatus) polysaccharide has therapeutic value in the treatment of chronic hepatitis B.Sep 01, 1993

Consumption of Agaricus brasiliensis KA21 for 12 weeks led to many beneficial improvements in health. Dec 31, 2014

Cordyceps and artemisinin prevent the recurrence of lupus nephritis.Mar 01, 2002

Cordyceps may improve renal function and cellular immune function in chronic kidney failure. Jun 01, 1992

Cordyceps may reduce the need for anti-rejection drugs and improve the outcome of renal transplantation. Jun 01, 2009

Dietary intakes of mushrooms and green tea combine to reduce the risk of breast cancer in Chinese women.Mar 15, 2009

Dongchongxiacao (Cordyceps) can reduce serum markers of airway inflammation of asthmatics.Sep 01, 2005

Effect of supplemental antioxidant-based therapy on the oxidative stress level in COVID-19 patients.Feb 28, 2023

Efficacy and safety of orally administered Lentinula edodes mycelia extract for patients undergoing cancer chemotherapy.Dec 31, 2010

Efficacy of Lentinula edodes mycelia extract on chemotherapy-related tasted disorders in pancreatic cancer patients.Dec 31, 2022

Fermentation of Pleurotus ostreatus and Ganoderma lucidum mushrooms and their extracts by the gut microbiota of healthy and osteopenic women.Jan 31, 2021

Habitual mushroom intake might help to prevent prostate cancer.Sep 03, 2019

Hericium erinaceus improves mood and sleep disorders in patients affected by overweight or obesity.Dec 31, 2018

Hericium erinaceus intake results in a reduction of depression and anxiety in mice by 4 weeks. Aug 01, 2010

Immunomodulation with β-glucan from Pleurotus ostreatus in patients with endocrine-dependent breast cancer.Nov 16, 2021

Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections.Jan 31, 2013

Improvement of cognitive functions by oral intake of Hericium erinaceus Dec 31, 2018

Lion's mane improves mild cognitive impairment in human subjects. Mar 01, 2009

Long-term use of combined conventional medicine and Chinese herbal medicine decreases the mortality risk of patients with lung cancer.Jul 31, 2020

Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome.Nov 30, 2010

Mushroom mycelium extract was an ineffective treatment for reducing 50% or more the patient prostate specific antigen values.Sep 30, 2010

Mycoprotein and tofu have satiating properties that persist for several hours after a meal.Jan 01, 2006

Oyster mushroom reduced blood glucose and cholesterol in diabetic subjects.Jan 01, 2007

Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity.Dec 31, 2021

Prevention of early Alzheimer's disease by Erinacine A-enriched Hericium erinaceus mycelia.Dec 31, 2019

Regular shiitake mushroom consumption resulted in improved immunity.Dec 31, 2014

Reishi (Ganoderma lucidum) safely improves lower urinary tract symptoms in men with benign prostatic hyperplasia. Sep 01, 2008

Reishi (Ganoderma) has significant therapeutic value in patients with FSGS. Jan 01, 2004

Reishi reduces pain from postherpetic neuralgia. Mar 01, 2006

Results suggest that adherence to a diet rich in vegetables, fruits, and typical Japanese foods is associated with a lower probability of having depressive symptoms.Jul 14, 2015

The mushroom Grifola umbellata is superior to mitomycin C in preventing postoperative recurrence of bladder cancer. Sep 05, 2007

The present intervention demonstrated the antioxidation, anti-aging and hepatoprotective nature of Ganoderma lucidum.Nov 30, 2017

These results found increasingly improved symptom score in the AndoSan group.Dec 31, 2015

This study demonstrates that β-glucans from G. lucidum increase the frequency of immune system cells in the peripheral blood.Dec 31, 2017

White button mushroom appears to both impact PSA levels and modulate the biology of biochemically recurrent prostate cancer.Aug 31, 2015

An extract of G. lucidum spores suppressed cholangiocarcinoma migration in vitro through inhibition of TGF-β1-induced EMT.May 14, 2016

Anti-inflammatory effect of mushrooms in dengue-infected human monocytes.Nov 30, 2019

Chaga mushroom extract can inhibit the proliferation of tumor cells.Dec 31, 2013

Combined application of Grifola frondosa and vitamin C induced cell apoptosis and autophagy in vitro.Sep 10, 2017

Ganoderic acids suppress growth and invasive behavior of breast cancer cells.Apr 30, 2008

Protective effects of Cordyceps sinensis exopolysaccharide‑selenium nanoparticles on H2O2-induced oxidative stress in HepG2 cells.May 28, 2022

These preliminary results demonstrated anti-genotoxic properties of Agaricus blazei.Dec 31, 2016

Triterpene ganoderic acid inhibited production of TNF-α and other proinflammatory cytokines by PBMCs and inflamed CD colonic mucosa due to blockage of NF-κB activation.May 18, 2015

verticillin A from Verticillium-infected wild mushrooms as a potent anti-cancer agent that effectively suppresses 5-FU-resistant human colon cancer cells. Aug 31, 2015

A case report of Korean medicine therapy as a substitute for chemotherapy for metastatic breast cancer. Dec 31, 2014

A patient with annular cutaneous sarcoidosis showed almost complete regression of lesions.Feb 29, 2016

Balancing adipocyte production and lipid metabolism to treat obesity-induced diabetes with a novel proteoglycan from Ganoderma lucidum.Aug 07, 2023

Cordycepin enhances radiosensitivity to induce apoptosis through cell cycle arrest, caspase pathway and ER stress in MA-10 mouse Leydig tumor cells.Dec 31, 2021

Erinacine A attenuates glutamate transporter 1 downregulation and protects against ischemic brain injury.Sep 30, 2022

Erinacine A prevents lipopolysaccharide-mediated glial cell activation to protect dopaminergic neurons against inflammatory factor-induced cell death.Jan 11, 2022

Medicinal Mushrooms

View the Evidence:
1163 Abstracts with Medicinal Mushrooms Research