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Melatonin
Views 19087
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Abstracts
Focused Research Topics
Focus Your Research
Click any topic below to filter + focus research
341 Diseases Researched for Melatonin
Name
AC
CK
Focus
Oxidative Stress
78
203
Breast Cancer
41
86
Sleep Disorders
7
74
Inflammation
23
66
Alzheimer's Disease
25
62
Delirium
4
51
Circadian Dysregulation
8
46
Insomnia
5
42
Parkinson's Disease
10
40
Hormone Imbalances: Low Melatonin
7
38
Neurodegenerative Diseases
14
38
Diabetes Mellitus: Type 2
8
32
Lipid Peroxidation
12
32
Chemotherapy and Radiation Toxicity
9
31
C-Reactive Protein
2
30
Tinnitus
3
30
Cancers: All
8
27
Brain Injury: Traumatic
5
26
Aging
14
25
Headache
6
24
Prostate Cancer
5
24
Chronic Pain
4
23
Jet Lag
4
23
Bisphenol Toxicity
14
22
Metabolic Syndrome X
2
22
Obesity
12
22
Gastroesophageal Reflux
3
21
Headache: Migraine
3
21
Liver Cancer
12
21
Muscle Damage: Exercise-Induced
3
21
Burns
1
20
Delayed Sleep Phase Disorder
1
20
Depressive Disorder
2
20
Multiple Sclerosis: Relapsing-Remitting
2
20
Overweight
1
20
Purpura: Thrombocytopenic
2
20
Thrombocytopenia
2
20
Aging: Brain
9
18
Cognitive Decline/Dysfunction
5
18
Multiple Sclerosis
7
18
Osteoporosis
5
17
DNA damage
8
16
Depression
10
16
Testicular Injury: Chemical/Metal Induced
9
16
Ovarian Cancer
5
15
Brain: Oxidative Stress
8
14
Chemically-Induced Liver Damage
3
14
Epilepsy
4
14
Sepsis
4
14
Aging Skin
3
13
Aluminum Toxicity
7
13
Colorectal Cancer
4
13
Fibromyalgia
3
13
Infertility: Male
6
13
Lipopolysaccharide-Induced Toxicity
6
13
Autism
2
12
Breast Cancer: Metastatic
2
12
Chemotherapy-Induced Toxicity: Cyclophosphamide
2
12
Nocturia
2
12
Periodontal Diseases
3
12
Scoliosis
2
12
Anxiety Disorders
2
11
Benzo[a]pyrene-induced Toxicity
2
11
Bipolar Disorder
2
11
Pancreatitis
2
11
Radiation Induced Illness
6
11
Skin Diseases
2
11
Abdominal Obesity (Midsection Fat)
1
10
Aneurysmal subarachnoid hemorrhage (SAH)
1
10
Asperger Syndrome
1
10
Athletic Performance
1
10
Bone Fractures
1
10
Brain Inflammation
6
10
Cardiac Surgery
1
10
Cesarean Section
1
10
Chronic Fatigue Syndrome
1
10
Cirrhosis
1
10
Coronary Artery Disease
1
10
Coronary Bypass Surgery
1
10
Cortisol: High
1
10
Depression: Breast Cancer Related
1
10
Dyspepsia
1
10
Erythema
1
10
Female
1
10
Graves Disease
1
10
Helicobacter Pylori Infection
1
10
Hemodialysis
1
10
Human Growth Hormone: Enhancement
1
10
Melasma
1
10
Mitochondrial Dysfunction
6
10
Oral Mucositis
1
10
Osteopenia
1
10
Retinal Diseases
1
10
Retinal Sensitivity
1
10
Sclerosis: Systemic
1
10
Skin Diseases: Photo-Aging
1
10
Spinal Cord Injuries
5
10
Weight Gain: Drug-Induced
1
10
Anxiety
6
9
Diabetic Nephropathy
5
9
Infertility
3
9
Osteosarcoma
5
9
Cancer Metastasis
4
8
Liver Injury: Ischemia/reperfusion
5
8
Mobile Phone-Induced Oxidative Stress
4
8
Periodontitis
4
8
Stroke: Ischemic
4
8
Hypertension
4
7
Myocardial Infarction
4
7
Sperm Quality: Low
2
7
Cadmium Poisoning
4
6
Cardiovascular Diseases
5
6
Endothelial Dysfunction
4
6
High Fat Diet
3
6
High Fructose Diet
3
6
Insulin Resistance
3
6
Kidney Damage
3
6
Kidney Damage: Drug-Induced
3
6
Lung Cancer
2
6
Myocardial Ischemia
3
6
Stress
3
6
Stroke: Attenuation/Recovery
5
6
Cervical Cancer
4
5
Chemotherapy-Induced Toxicity: Doxorubicin
3
5
Coronavirus Infection
4
5
Endometriosis
3
5
Huntington Disease
4
5
Neuroblastoma
1
5
Osteoporosis: Inflammation Induced
1
5
Pancreatic Cancer
4
5
Ultraviolet Radiation Induced Damage
4
5
Aging: Immunosenecence
3
4
Air Pollution Linked Toxicity
2
4
Alcohol Toxicity
2
4
Alcoholic Liver Disease
2
4
Amyotrophic Lateral Sclerosis
4
4
Breast Cancer: Triple Negative
3
4
Cerebral Hypoperfusion
2
4
Cerebral Ischemia
2
4
Chemotherapy-Induced Toxicity
3
4
Chemotherapy-Induced Toxicity: Cisplatin
2
4
Chemotherapy-Induced Toxicity: Gentamicin
2
4
Colitis
2
4
Colon Cancer
4
4
Diabetic Retinopathy
2
4
Drug-Induced Toxicity: Methotrexate
2
4
Dysbiosis
2
4
Electromagnetic Radiation Mitigation
2
4
Encephalitis
2
4
Fluoride Toxicity
3
4
Glioblastoma
4
4
Glyphosate Toxicity
2
4
Hypertension: Pulmonary
2
4
Hypoxia
2
4
Ischemia
3
4
Kidney Diseases
2
4
Leukemia
3
4
Liver Fibrosis
2
4
Lung Injury: Acute
3
4
Memory Disorders
2
4
Metabolic Diseases
2
4
Neonatal Stroke
2
4
Nicotine/Tobacco Toxicity
3
4
Pesticide Toxicity
2
4
Pregnancy Complications
2
4
Arsenic Poisoning
2
3
Brain Damage
2
3
Brain Ischemia
2
3
Breast Cancer: Estrogen
3
3
Breast Cancer: estrogen receptor alpha-positive
2
3
Gastric Ulcer
2
3
Irritable Bowel Syndrome
3
3
Liver Damage
2
3
Liver Disease
2
3
Osteoarthritis
2
3
Pituitary Tumours
2
3
Psychiatric Disorders
2
3
Schizophrenia
2
3
Systemic Lupus Erythematosus
3
3
Ulcerative Colitis
2
3
Acetaminophen (Tylenol) Toxicity
1
2
Acrylamide-induced toxicity
1
2
Aflatoxicosis
1
2
Aging: Heart
1
2
Amnesia
1
2
Amyotrophic lateral sclerosis (ALS)
2
2
Atherosclerosis
1
2
Autism Spectrum Disorders
2
2
Autoimmune Diseases
2
2
Benzene Toxicity
1
2
Bile Duct Injury
1
2
Bone Diseases
1
2
Breast Cancer: Lung Metastasis
1
2
Cancer: Prostate
1
2
Cardiac Hypertrophy
1
2
Cardiomyopathy
1
2
Cataract: Radiation-Induced
1
2
Cell Phone Induced Disease
1
2
Chemotherapy-Induced Kidney Damage
1
2
Chemotherapy-Induced Toxicity: Epirubicin
1
2
Chemotherapy-Induced Toxicity: Oxaliplatin
1
2
Chronic Kidney Disease (CKD)
2
2
Cocaine Addiction
1
2
Cocaine Withdrawal
1
2
Colon Cancer: Prevention
1
2
Cough
1
2
Coxsackievirus Infections
1
2
Degenerative Disk Disease
1
2
Dementia
1
2
Demyelinating Diseases
1
2
Depression
1
2
Depression: Stress Related
1
2
Diabetes
1
2
Diabetes Mellitus: Type 1
2
2
Diabetes: Cognitive Dysfunction
1
2
Diabetes: Oxidative Stress
1
2
Diabetic Complications
1
2
Drug-Induced Toxicity: Bisphosphonates
1
2
Drug-Induced Toxicity: Indomethacin
1
2
Edema
1
2
Endometrial Cancer
1
2
Estrogen Deficiency
1
2
Fructose-Induced Toxicity
1
2
Gastric Cancer
2
2
Glaucoma
3
2
Gliomas
1
2
Glutathione Deficiency
1
2
HIV Drug-Induced Toxicity
1
2
Headache: Cluster
2
2
Heart Disease
1
2
Herbicide Toxicity
1
2
High Homocysteine
1
2
High Sugar Diet
1
2
Hydrogen Peroxide Induced Toxicity
2
2
Hyperalgesia
1
2
Hyperbilirubinemia: Hereditary
1
2
Hypercholesterolemia
1
2
Hyperglycemia
1
2
Hyperlipidemia
1
2
Hyperthyroidism
1
2
Hypoxia: Brain
1
2
Immune Disorders: Low Immune Function
1
2
Inflammation: Brain
1
2
Intestinal Ischemia
1
2
Kidney Damage: Chemically-Induced
1
2
Kidney Failure
1
2
Kidney Fibrosis
2
2
Leiomyosarcoma
1
2
Liver Cirrhosis
1
2
Low Immune Function: Natural Killer Cells
1
2
Macular Degeneration
3
2
Malaria
1
2
Melanoma
2
2
Morphine Tolerance/Dependence
1
2
Multi-Organ Failure
1
2
Myocarditis: Viral
1
2
Neural Tube Defects
1
2
Neuralgia: Post Herpetic
1
2
Neuritis: Brachial Plexus
1
2
Obstructive Nephropathy
1
2
Optic Neuritis
1
2
Oral Cancer
2
2
Ovariectomy Associated Adverse Changes
1
2
Plasmodium Infections
1
2
Prediabetes
1
2
Prenatal Chemical Exposures
1
2
Prenatal Nutrition: Prevention of Problems
1
2
Quality of Life: Poor
1
2
Radiation
1
2
Radiation-Induced Illness: Cesium-137 Exposure
1
2
Sciatic Nerve Crush Injury
1
2
Sleep Apnea: Central
1
2
Snake Bite: Venom Toxicity
1
2
Squamous cell carcinoma
2
2
Subarachnoid hemorrhage
2
2
Testicular Injury: Formaldehyde-Induced
1
2
Testicular Injury: Nicotine-Induced
1
2
Traumatic Brain Injury
1
2
Tumors
2
2
Vaginal Cancer
1
2
Wound Healing
1
2
Acute Respiratory Distress Syndrome
1
1
Acute T cell Leukemias
1
1
Amphetamine Addiction/Withdrawal
1
1
Animal Cancers
1
1
Asphyxia
1
1
Brain Edema
1
1
Cancers: Drug Resistant
1
1
Carcinoma: Non-Small-Cell Lung
1
1
Chemotherapy-Induced Toxicity: Arsenic Trioxide
1
1
Chronic Disease
1
1
Crohn's Disease
1
1
Ebola Virus Infections
1
1
Encephalopathy: Hypoxic
1
1
Endocrine Diseases
1
1
Esophageal Cancer
1
1
Estrogen Dominance
1
1
Fractures: Bone
1
1
Fragile X Syndrome
1
1
Gallbladder Inflammation
1
1
Gallstones
1
1
Gastritis
1
1
Glioma
1
1
Head and Neck Cancer
1
1
Heavy Metal Toxicity
1
1
Inflammatory Bowel Diseases
1
1
Leiomyoma
1
1
Liver Damage: Aflatoxin-Induced
1
1
Lung Injury: Smoke-Induced
1
1
Lymphoma: B-Cell
1
1
Mastitis
1
1
Migraine Disorders
1
1
Migraines
1
1
Mitochondrial Diseases
1
1
Mood Disorders
1
1
Myasthenia Gravis
1
1
Napthalene-Induced Toxicity
1
1
Nasopharyngeal Cancer
1
1
Non-Small-Cell Lung Carcinoma
1
1
Organ Transplantation
1
1
Organ Transplantation: Liver
1
1
Osteoarthritis: Knee
1
1
Pancreatic Diseases
1
1
Photooxidative Stress
1
1
Pineal Gland Calcification
1
1
Pineal Gland Diseases
1
1
Post-Traumatic Stress Disorders (PTSD)
1
1
Proliferative Vitreoretinopathy (PVR)
1
1
Prostatic Hyperplasia: Benign
1
1
Pulmonary Fibrosis
1
1
Renal Cancer
1
1
Retinopathy of Prematurity
1
1
Rheumatoid Arthritis
1
1
Sarcoma: Ewing's
1
1
Septic Shock
1
1
Stroke: Hemorrhagic
1
1
Tongue Cancer
1
1
Vaccine-induced Toxicity
1
1
Wound Healing: Delayed
1
1
Abdominal Adhesions
1
0
Sarcoidosis
1
0
120 Pharmacological Actions Researched for Melatonin
Name
AC
CK
Focus
Antioxidants
179
448
Anti-Inflammatory Agents
89
239
Neuroprotective Agents
97
216
Apoptotic
46
67
Tumor Necrosis Factor (TNF) Alpha Inhibitor
20
67
Anti-Apoptotic
36
61
Antiproliferative
41
60
Interleukin-6 Downregulation
7
45
Renoprotective
24
45
Hepatoprotective
24
44
Prophylactic Agents
7
44
Antidepressive Agents
10
43
Radioprotective
18
42
Cardioprotective
20
37
NF-kappaB Inhibitor
20
32
Anti-metastatic
22
29
Brain-derived neurotrophic factor modulator
4
26
Hypoglycemic Agents
5
26
Malondialdehyde Down-regulation
9
26
Chemosensitizer
19
24
Interleukin-1 beta downregulation
12
23
Regenerative
7
23
Cyclooxygenase 2 Inhibitors
11
22
Immunomodulatory
17
22
Secretagogue
3
22
Cytoprotective
12
21
Gastrointestinal Agents
7
21
Antinoceceptive
1
20
Chemoprotective Agents
11
19
Chemotherapeutic
10
19
Nrf2 activation
13
19
Osteogenic
4
19
Tumor Suppressor Protein p53 Upregulation
15
18
Angiogenesis Inhibitors
8
14
Insulin Sensitizers
2
12
Matrix metalloproteinase-9 (MMP-9) inhibitor
10
12
Superoxide Dismutase Up-regulation
7
12
Chemopreventive
7
11
Genoprotective
5
11
Proton Pump Inhibitor
2
11
Adiponectin upregulation
1
10
Anxiolytic
1
10
Bcl-2 protein down-regulation
7
10
Gastroprotective
6
10
Hypnotics and Sedatives
1
10
Insulin-Like Growth Factor Inhibition/Downregulation
1
10
Matrix metalloproteinase-2 (MMP-2) inhibitor
5
10
Vasodilator Agents
1
10
Anticarcinogenic Agents
5
9
Antineoplastic Agents
7
9
Antioxidant
3
9
Antihypertensive Agents
5
8
Cell cycle arrest
8
8
Hypolipidemic
4
8
Vascular Endothelial Growth Factor Inhibitors
4
8
Heme oxygenase-1 up-regulation
6
7
MicroRNA modulator
6
7
Analgesics
5
6
Anti-Anxiety Agents
4
6
Autophagy Inhibitors
4
6
Nitric Oxide Inhibitor
1
5
Prostaglandin PGE2 downregulation
1
5
Anti-Fibrotic
3
4
Antiviral Agents
3
4
Calcium Channel Blockers
2
4
Osteoprotective
3
4
Photoprotective
3
4
Radiosensitizer
4
4
Antimutagenic Agents
2
3
Aromatase Inhibitors
3
3
Autophagy Up-regulation
2
3
Caspase-3 Activation
2
3
DNA Repair Up-regulation
2
3
Detoxifier
2
3
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
3
3
Immunostimulatory
3
3
Acetylcholinesterase Inhibitor
1
2
Adenosine Monophosphate (AMP)-activated Protein Kinase (AMPK
1
2
Anti-Angiogenic
2
2
Anti-Proliferative
1
2
Anti-Ulcer Agents
1
2
Anticholesteremic Agents
1
2
Anticonvulsants
1
2
BRCA-1 Downregulation
2
2
Fertility Agents
1
2
Fertility Agents: Male
1
2
Heat Shock Protein Down-Regulation
1
2
Interleukin-10 downregulation
1
2
Interleukin-4 downregulation
1
2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
1
2
Matrix metalloproteinase-8 (MMP-8) inhibitor
1
2
Neurogenesis
1
2
Neuroplasticity enhancement
1
2
Neurorestorative
1
2
Receptor-Related Orphan Receptor (ROR)-Alpha1 Inhibitor
1
2
SIRT1 Activator
1
2
12-lipoxygenase (12-LOX) Inhibitor
1
1
Apaf-1/caspase-dependent apoptotic pathway activator
1
1
Bax/Bcl2 ratio: Increase
1
1
Caspase-9 Activation
1
1
Catalase Up-Regulation
1
1
Cell Differentiation Inducer
1
1
Chondroprotective
1
1
Cyclooxygenase Inhibitors
1
1
Drug synergy
1
1
Enzyme Inhibitors
1
1
Glutathione Upregulation
1
1
Immunomodulatory: Th17 downregulation
1
1
Interleukin-8 downregulation
1
1
Matrix metalloproteinase-1 (MMP-1) inhibitor
1
1
P21 Activation
1
1
P38 Mitogen-Activated Protein Kinase Modulator
1
1
PI3K/Akt/signaling suppression
1
1
Selective estrogen enzyme modulator (SEEM)
1
1
Telomerase Inhibitor
1
1
Telomerase Upregulation
1
1
Transforming growth factor beta (TGF-β) inhibitor
1
1
Vascular Endothelial Growth Factor A Inhibitor
1
1
Wnt/β-catenin signaling pathway modulation
1
1
p300/NF-κB down-regulation
1
1
Research Articles
647
Cumulative Knowledge Score
1046
Overall Research Rating
EXCELLENT
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View the Evidence:
754 Abstracts with Melatonin Research
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[+]
Adjunctive melatonin supplementation can significantly improve the periodontal status after non-surgical treatment.
Mar 14, 2022
Click here to read the entire abstract
Pubmed Data
: Inflammopharmacology. 2022 Mar 15. Epub 2022 Mar 15. PMID:
35290552
Article Published Date
: Mar 14, 2022
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Melatonin
Diseases
:
Periodontitis
Additional Keywords
:
Risk Reduction
[+]
Melatonin receptor agonists for the prevention of delirium.
May 05, 2022
Click here to read the entire abstract
Pubmed Data
: Curr Neuropharmacol. 2022 May 6. Epub 2022 May 6. PMID:
35524672
Article Published Date
: May 05, 2022
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Melatonin
Diseases
:
Delirium
Pharmacological Actions
:
Neuroprotective Agents
[+]
The therapeutic effect of exogenous melatonin on depressive symptoms.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Psychiatry. 2022 ;13:737972. Epub 2022 Mar 17. PMID:
35370838
Article Published Date
: Dec 31, 2021
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Melatonin
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
[+]
Effects of melatonin supplementation on oxidative stress.
Nov 10, 2020
Click here to read the entire abstract
Pubmed Data
: Horm Mol Biol Clin Investig. 2020 Nov 11. Epub 2020 Nov 11. PMID:
33185572
Article Published Date
: Nov 10, 2020
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Melatonin
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Melatonin could have an effect on body weight.
Nov 28, 2016
Click here to read the entire abstract
Pubmed Data
: Curr Pharm Des. 2016 Nov 29. Epub 2016 Nov 29. PMID:
27897121
Article Published Date
: Nov 28, 2016
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Melatonin
Diseases
:
Overweight
Additional Keywords
:
insomnia
,
melatonin
,
overweight
,
sleep
,
weight-gain
,
Weight Loss
[+]
Melatonin intake was shown to have a significant impact on improving oxidative stress parameters.
Sep 28, 2020
Click here to read the entire abstract
Pubmed Data
: Pharmacol Res. 2020 Sep 29 ;161:105210. Epub 2020 Sep 29. PMID:
33007423
Article Published Date
: Sep 28, 2020
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Melatonin
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Melatonin is effective in advancing sleep-wake rhythm and endogenous melatonin rhythm in delayed sleep phase disorder.
Dec 01, 2010
Click here to read the entire abstract
Pubmed Data
: Sleep. 2010 Dec;33(12):1605-14. PMID:
21120122
Article Published Date
: Dec 01, 2010
Study Type
: Meta Analysis
Additional Links
Substances
:
Melatonin
Diseases
:
Delayed Sleep Phase Disorder
,
Sleep Disorders
[+]
Melatonin reduces the risk of death from cancer.
Nov 01, 2005
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2005 Nov;39(4):360-6. PMID:
16207291
Article Published Date
: Nov 01, 2005
Study Type
: Meta Analysis
Additional Links
Substances
:
Melatonin
Diseases
:
Cancers: All
[+]
Melatonin supplementation had a significant preventive effect in decreasing the incidence of delirium in elderly patients.
Jul 20, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Neurobiol. 2015 Jul 21. Epub 2015 Jul 21. PMID:
26189834
Article Published Date
: Jul 20, 2015
Study Type
: Meta Analysis
Additional Links
Substances
:
Melatonin
Diseases
:
Delirium
Additional Keywords
:
Risk Reduction
,
Significant Treatment Outcome
[+]
Perioperative melatonin reduced the incidence of delirium in older adults in the included studies.
Oct 15, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Geriatr. 2019 Oct 16 ;19(1):272. Epub 2019 Oct 16. PMID:
31619178
Article Published Date
: Oct 15, 2019
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Melatonin
Diseases
:
Delirium
Pharmacological Actions
:
Neuroprotective Agents
[+]
Protective effects of melatonin against severe burn-induced distant organ injury.
Nov 26, 2020
Click here to read the entire abstract
Article Publish Status
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Pubmed Data
: Antioxidants (Basel). 2020 Nov 27 ;9(12). Epub 2020 Nov 27. PMID:
33261180
Article Published Date
: Nov 26, 2020
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Melatonin
Diseases
:
Burns
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
The current meta-analysis supports the use of melatonin for anti-nociception.
Nov 20, 2017
Click here to read the entire abstract
Article Publish Status
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Pubmed Data
: Oncotarget. 2017 Nov 21 ;8(59):100582-100592. Epub 2017 Oct 5. PMID:
29246003
Article Published Date
: Nov 20, 2017
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Melatonin
Diseases
:
Chronic Pain
Pharmacological Actions
:
Antinoceceptive
,
Brain-derived neurotrophic factor modulator
Additional Keywords
:
Antinoceceptive
,
Brain-derived neurotrophic factor modulator
,
Chronic Pain
,
melatonin
[+]
There is evidence that melatonin treatment after traumatic brain injury significantly improves both behavioural outcomes and pathological outcomes.
Jun 13, 2018
Click here to read the entire abstract
Pubmed Data
: J Neurotrauma. 2018 Jun 14. Epub 2018 Jun 14. PMID:
29901413
Article Published Date
: Jun 13, 2018
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Melatonin
Diseases
:
Brain Injury: Traumatic
Pharmacological Actions
:
Neuroprotective Agents
[+]
This meta-analysis clearly supports the use of melatonin as a management for patients with secondary sleep disorders.
Jun 13, 2018
Click here to read the entire abstract
Pubmed Data
: Front Neuroendocrinol. 2018 Jun 14. Epub 2018 Jun 14. PMID:
29908879
Article Published Date
: Jun 13, 2018
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Melatonin
Diseases
:
Sleep Disorders
[+]
This meta-analysis provided some evidence that melatonin improves sleep quality in patients with AD and PD.
Aug 08, 2015
Click here to read the entire abstract
Pubmed Data
: Neurol Sci. 2015 Aug 9. Epub 2015 Aug 9. PMID:
26255301
Article Published Date
: Aug 08, 2015
Study Type
: Meta Analysis
Additional Links
Substances
:
Melatonin
Diseases
:
Alzheimer's Disease
,
Neurodegenerative Diseases
,
Parkinson's Disease
[+]
This meta-analysis showed the promising effect of melatonin administration on reducing CRP and IL-6 among patients with MetS and related disorders.
Jun 14, 2018
Click here to read the entire abstract
Pubmed Data
: Inflammopharmacology. 2018 Jun 15. Epub 2018 Jun 15. PMID:
29907916
Article Published Date
: Jun 14, 2018
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Melatonin
Diseases
:
C-Reactive Protein
,
Metabolic Syndrome X
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
[+]
A dietary supplement containing melatonin, l-tryptophan, vitamin B6, folic acid, vitamin B12, methionine and betaine, is superior to omeprazole in treating GERD.
Oct 01, 2006
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2006 Oct;41(3):195-200. PMID:
16948779
Article Published Date
: Oct 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
Betaine
,
Folic Acid
,
Melatonin
,
Methionine
,
Tryptophan
,
Vitamin B-12
,
Vitamin B-6
Diseases
:
Gastroesophageal Reflux
Pharmacological Actions
:
Proton Pump Inhibitor
Additional Keywords
:
Superiority of Natural Substances versus Drugs
[+]
A low physiological dose of melatonin (.5 mg) is almost effective as a pharmacological dose of 5.0 mg in alleviating jet lag.
Nov 01, 1998
Click here to read the entire abstract
Pubmed Data
: Chronobiol Int. 1998 Nov;15(6):655-66. PMID:
9844753
Article Published Date
: Nov 01, 1998
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Jet Lag
Additional Keywords
:
Less is More
[+]
Administration of melatonin as an adjuvant therapy in the treatment of neonatal sepsis is associated with improvement of clinical and laboratory outcomes.
Oct 08, 2015
Click here to read the entire abstract
Pubmed Data
: J Neonatal Perinatal Med. 2015 Oct 9. Epub 2015 Oct 9. PMID:
26485549
Article Published Date
: Oct 08, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Sepsis
[+]
Administration of melatonin, alone or in a combination with fluoxetine was effective in the treatment of patients with fibromyalgia.
Mar 31, 2011
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2011 Apr ;50(3):267-71. Epub 2010 Dec 16. PMID:
21158908
Article Published Date
: Mar 31, 2011
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Fibromyalgia
Additional Keywords
:
Significant Treatment Outcome
Problem Substances
:
Fluoxetine (trade name Prozac)
[+]
Application of melatonin cream 12.5% protects against natural sunlight induced erythema.
Aug 08, 2016
Click here to read the entire abstract
Pubmed Data
: J Dermatol Sci. 2016 Aug 9. Epub 2016 Aug 9. PMID:
27543364
Article Published Date
: Aug 08, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Erythema
,
Skin Diseases
,
Skin Diseases: Photo-Aging
Additional Keywords
:
Dose Response
[+]
Beneficial effect of melatonin on blood loss after cesarean section.
Sep 30, 2019
Click here to read the entire abstract
Pubmed Data
: J Obstet Gynaecol India. 2019 Oct ;69(5):436-443. Epub 2019 Apr 24. PMID:
31598047
Article Published Date
: Sep 30, 2019
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cesarean Section
Additional Keywords
:
Risk Reduction
[+]
Both melatonin and light treatment have positive effects on various sleep outcomes.
Oct 09, 2016
Click here to read the entire abstract
Pubmed Data
: Sleep. 2016 Oct 10. Epub 2016 Aug 10. PMID:
27748241
Article Published Date
: Oct 09, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Insomnia
,
Sleep Disorders
Therapeutic Actions
:
Light Therapy
[+]
Bright light treatment in elderly patients with major depressive disorder improved mood, enhanced sleep efficiency and increased melatonin level.
Dec 31, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Arch Gen Psychiatry. 2011 Jan ;68(1):61-70. PMID:
21199966
Article Published Date
: Dec 31, 2010
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Depressive Disorder
Therapeutic Actions
:
Light Therapy
Pharmacological Actions
:
Antidepressive Agents
[+]
Circadian melatonin disruption can be used as an indicator of delirium.
Sep 30, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sleep Sci. 2016 Oct-Dec;9(4):285-288. Epub 2016 Aug 10. PMID:
28154742
Article Published Date
: Sep 30, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Circadian Dysregulation
,
Delirium
[+]
Coadministration of melatonin with olanzapine in adolescents with bipolar disorder could reduce the sharp weight gain side effect.
Mar 23, 2017
Click here to read the entire abstract
Pubmed Data
: J Child Adolesc Psychopharmacol. 2017 Mar 24. Epub 2017 Mar 24. PMID:
28339282
Article Published Date
: Mar 23, 2017
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Weight Gain: Drug-Induced
Additional Keywords
:
Risk Reduction
Problem Substances
:
Olanzapine
[+]
Combined treatment including melatonin resulted in the improvement of general conditions in 81.7% of the patients
Dec 31, 2012
Click here to read the entire abstract
Pubmed Data
: Klin Med (Mosk). 2013 ;91(3):50-3. PMID:
23789453
Article Published Date
: Dec 31, 2012
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chemically-Induced Liver Damage
Additional Keywords
:
Plant Extracts
[+]
Disruption of melatonin circadian rhythm production is frequent among RRMS patients and seemingly related to higher disability and fatigue scores.
Jun 14, 2015
Click here to read the entire abstract
Pubmed Data
: J Neurol Sci. 2015 Jun 15 ;353(1-2):166-8. Epub 2015 Apr 7. PMID:
25930714
Article Published Date
: Jun 14, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Circadian Dysregulation
,
Hormone Imbalances: Low Melatonin
,
Inflammation
,
Multiple Sclerosis: Relapsing-Remitting
[+]
Effects of melatonin alone or associated with acyclovir on the suppressive treatment of recurrent genital herpes.
Apr 03, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomedicines. 2023 Apr 4 ;11(4). Epub 2023 Apr 4. PMID:
37189706
Article Published Date
: Apr 03, 2023
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Genital Herpes
Pharmacological Actions
:
Analgesics
,
Antiviral Agents
[+]
Effects of melatonin on sleep disturbances in multiple sclerosis.
Sep 30, 2021
Click here to read the entire abstract
Pubmed Data
: Mult Scler J Exp Transl Clin. 2021 Oct ;7(4):20552173211048756. Epub 2021 Nov 5. PMID:
34777854
Article Published Date
: Sep 30, 2021
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Multiple Sclerosis
,
Sleep Disorders
[+]
Effects of melatonin prolonged-release on both sleep and motor symptoms in Parkinson's disease: a preliminary evidence.
May 09, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Neurol Sci. 2022 May 10. Epub 2022 May 10. PMID:
35536495
Article Published Date
: May 09, 2022
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Parkinson's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Efficacy of melatonin for sleep disturbance in middle-aged primary insomnia.
Oct 16, 2020
Click here to read the entire abstract
Pubmed Data
: Sleep Med. 2020 Oct 17 ;76:113-119. Epub 2020 Oct 17. PMID:
33157425
Article Published Date
: Oct 16, 2020
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Insomnia
Pharmacological Actions
:
Hypnotics and Sedatives
[+]
Elevated melatonin during mania and elevated cortisol during depression may characterize bipolar disorder.
May 01, 1989
Click here to read the entire abstract
Pubmed Data
: J Nerv Ment Dis. 1989 May;177(5):300-3. PMID:
2708973
Article Published Date
: May 01, 1989
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bipolar Disorder
,
Cortisol: High
[+]
Exercise-induced Human Growth Hormone secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjects.
Jul 01, 1999
Click here to read the entire abstract
Pubmed Data
: Eur J Endocrinol. 1999 Jul;141(1):22-6. PMID:
10407218
Article Published Date
: Jul 01, 1999
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Athletic Performance
,
Human Growth Hormone: Enhancement
Pharmacological Actions
:
Insulin-Like Growth Factor Inhibition/Downregulation
[+]
Exogenous melatonin reverses the enhanced oxidative damage to membrane lipids and improves skin biophysical characteristics in former-smokers.
Dec 22, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Ann Agric Environ Med. 2017 Dec 23 ;24(4):659-666. Epub 2017 May 11. PMID:
29284244
Article Published Date
: Dec 22, 2017
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging Skin
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Malondialdehyde Down-regulation
[+]
Geomagnetic activity may play a role in the entrainment of human melatonin rhythms.
Jun 12, 2008
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2008 Jun 13 ;438(1):76-9. Epub 2008 Apr 16. PMID:
18472329
Article Published Date
: Jun 12, 2008
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Additional Keywords
:
Geomagnetic Activity
[+]
Higher urinary melatonin levels were associated with reduced breast cancer risk in this cohort of postmenopausal women.
Nov 08, 2016
Click here to read the entire abstract
Pubmed Data
: Cancer Epidemiol Biomarkers Prev. 2016 Nov 9. Epub 2016 Nov 9. PMID:
28151704
Article Published Date
: Nov 08, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Breast Cancer
Additional Keywords
:
Risk Factors
,
Risk Reduction
[+]
Low-dose melatonin for sleep disturbances in early-stage cirrhosis.
Jul 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: JGH Open. 2020 Aug ;4(4):749-756. Epub 2020 May 18. PMID:
32782966
Article Published Date
: Jul 31, 2020
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cirrhosis
,
Sleep Disorders
[+]
Lower serum levels of melatonin in ovarian cancer patients which may contribute to the pathogenesis of ovarian cancer.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cancer. 2016 ;7(7):831-6. Epub 2016 Apr 27. PMID:
27162542
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Ovarian Cancer
Additional Keywords
:
Risk Reduction
[+]
Meditation results in acute increases in night-time plasma melatonin levels.
May 01, 2000
Click here to read the entire abstract
Pubmed Data
: Biol Psychol. 2000 May;53(1):69-78. PMID:
10876066
Article Published Date
: May 01, 2000
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Hormone Imbalances: Low Melatonin
Pharmacological Actions
:
Secretagogue
[+]
Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease.
Dec 11, 2017
Click here to read the entire abstract
Pubmed Data
: Clin Nutr. 2017 Dec 12. Epub 2017 Dec 12. PMID:
29275919
Article Published Date
: Dec 11, 2017
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Coronary Artery Disease
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Insulin Sensitizers
[+]
Melatonin and L-Tryptophan have a protective effect on acute pancreatitis
Jan 01, 2003
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2003 Jan;34(1):40-52. PMID:
12485371
Article Published Date
: Jan 01, 2003
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
,
Tryptophan
Diseases
:
Pancreatitis
Pharmacological Actions
:
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin and oxidative stress in melasma - an unexplored territory; a prospective study.
Mar 04, 2020
Click here to read the entire abstract
Pubmed Data
: Int J Dermatol. 2020 Mar 5. Epub 2020 Mar 5. PMID:
32141063
Article Published Date
: Mar 04, 2020
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Melasma
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Melatonin and to a lesser degree mothewort decrease retinal sensitivity and improves the emotional state in anxious young subjects.
Nov 01, 2006
Click here to read the entire abstract
Pubmed Data
: Eksp Klin Farmakol. 2006 Nov-Dec;69(6):17-9. PMID:
17209457
Article Published Date
: Nov 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Anxiety Disorders
,
Retinal Diseases
,
Retinal Sensitivity
Pharmacological Actions
:
Anxiolytic
Additional Keywords
:
Plant Extracts
[+]
Melatonin and vitamin E may be safe and effective in patients with systemic sclerosis.
Nov 01, 2010
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2010 Nov;26(5):673-8. PMID:
16428927
Article Published Date
: Nov 01, 2010
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
,
Vitamin E
Diseases
:
Sclerosis: Systemic
[+]
Melatonin appears to be effective in the treatment of sleep disturbances, as well as improving behavioral measures in children with Asperger disorder.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: Pharmacoepidemiol Drug Saf. 2009 Dec;18(12):1143-9. PMID:
12804129
Article Published Date
: Dec 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Asperger Syndrome
[+]
Melatonin can alleviate jet lag and tiredness after long haul flights.
Mar 18, 1989
Click here to read the entire abstract
Pubmed Data
: BMJ. 1989 Mar 18;298(6675):705-7. PMID:
2496815
Article Published Date
: Mar 18, 1989
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Jet Lag
[+]
Melatonin can modulate the inflammatory actions in periodontal patients.
Nov 30, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Clin Exp Dent. 2015 Dec ;7(5):e628-e633. Epub 2015 Dec 1. PMID:
26644840
Article Published Date
: Nov 30, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
C-Reactive Protein
,
Inflammation
,
Periodontal Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin could be effective and safe for decreasing daytime seizure frequency in patients with intractable epilepsy.
Feb 28, 2012
Click here to read the entire abstract
Pubmed Data
: J Child Neurol. 2012 Feb 28. Epub 2012 Feb 28. PMID:
22378657
Article Published Date
: Feb 28, 2012
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Epilepsy
[+]
Melatonin could be used in migraine prophylaxis treatments.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Iran J Child Neurol. 2018 ;12(1):47-54. PMID:
29379562
Article Published Date
: Dec 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Headache: Migraine
Pharmacological Actions
:
Prophylactic Agents
Additional Keywords
:
Natural Substances Versus Drugs
[+]
Melatonin could decrease fatigue in survivors of aneurysmal subarachnoid hemorrhage.
Nov 15, 2016
Click here to read the entire abstract
Pubmed Data
: Neurochirurgie. 2016 Nov 16. Epub 2016 Aug 16. PMID:
27865517
Article Published Date
: Nov 15, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aneurysmal subarachnoid hemorrhage (SAH)
[+]
Melatonin deficiency may play a role in the pathogenesis of adolescent idiopathic scoliosis - Article 2.
Apr 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2009 Apr;46(3):344-8. PMID:
19317797
Article Published Date
: Apr 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Scoliosis
[+]
Melatonin exerts beneficial effects in MS patients based on its' proved antioxidative properties.
Mar 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: J Physiol Pharmacol. 2016 Apr ;67(2):235-42. PMID:
27226183
Article Published Date
: Mar 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chronic Fatigue Syndrome
,
Multiple Sclerosis
Pharmacological Actions
:
Antioxidants
[+]
Melatonin has a drug sparing and synergistic effect with chemotherapy in the treatment of metastatic colorectal patients.
Mar 01, 2003
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2003 Mar-Apr;23(2C):1951-4. PMID:
12820485
Article Published Date
: Mar 01, 2003
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Colorectal Cancer
Additional Keywords
:
Drug-Plant-Vitamin Synergies
,
Drug Sparing
[+]
Melatonin has a role in the improvement of gastroesophageal reflux disease.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: BMC Gastroenterol. 2010;10:7. Epub 2010 Jan 18. PMID:
20082715
Article Published Date
: Jan 01, 2010
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Gastroesophageal Reflux
Additional Keywords
:
Drug: Omeprazole
[+]
Melatonin has been demonstrated to slow the proliferation of hormone-refractory prostate cancer in animal and human studies.
Oct 01, 2003
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2003 Oct;35(3):177-82. PMID:
12932201
Article Published Date
: Oct 01, 2003
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Prostate Cancer
Additional Keywords
:
Hormone Refractory Prostate Cancer
[+]
Melatonin increases overall survival of prostate cancer patients with poor prognosis after combined hormone radiation treatment.
Oct 12, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2020 Oct 13 ;11(41):3723-3729. Epub 2020 Oct 13. PMID:
33110479
Article Published Date
: Oct 12, 2020
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Chemotherapeutic
[+]
Melatonin ingestion after exhaustive late-evening exercise attenuate muscle damage, oxidative stress, and inflammation.
Dec 01, 2019
Click here to read the entire abstract
Pubmed Data
: Chronobiol Int. 2019 Dec 2:1-12. Epub 2019 Dec 2. PMID:
31790604
Article Published Date
: Dec 01, 2019
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Muscle Damage: Exercise-Induced
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
Melatonin is an effective and safe alternative for the treatment of chronic tension-type headache.
Nov 30, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pain Ther. 2020 Dec ;9(2):741-750. Epub 2020 Oct 16. PMID:
33067764
Article Published Date
: Nov 30, 2020
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Headache
Pharmacological Actions
:
Prophylactic Agents
[+]
Melatonin is associated with a statistically significant decrease in tinnitus intensity and improved sleep quality in patients with chronic tinnitus.
Jul 01, 2011
Click here to read the entire abstract
Pubmed Data
: Ann Otol Rhinol Laryngol. 2011 Jul ;120(7):433-40. PMID:
21859051
Article Published Date
: Jul 01, 2011
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Tinnitus
[+]
Melatonin levels are associated with hypothalamic gray matter volume loss and disease severity in PD patients.
Mar 11, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mov Disord. 2016 Mar 12. Epub 2016 Mar 12. PMID:
26971528
Article Published Date
: Mar 11, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Circadian Dysregulation
,
Parkinson's Disease
Additional Keywords
:
Risk Factors
[+]
Melatonin may be a safe treatment for patients with idiopathic tinnitus. Article 1
Feb 01, 2006
Click here to read the entire abstract
Pubmed Data
: Otolaryngol Head Neck Surg. 2006 Feb;134(2):210-3. PMID:
16455366
Article Published Date
: Feb 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Tinnitus
[+]
Melatonin may be a safe treatment for patients with idiopathic tinnitus. Article 2
Mar 01, 1998
Click here to read the entire abstract
Pubmed Data
: Laryngoscope. 1998 Mar;108(3):305-10. PMID:
9504599
Article Published Date
: Mar 01, 1998
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Tinnitus
[+]
Melatonin may be effective in treating refractory idiopathic thrombocytopenic purpura.
Dec 01, 2001
Click here to read the entire abstract
Pubmed Data
: Jpn J Pharmacol. 2001 Dec;87(4):327-32. PMID:
12424512
Article Published Date
: Dec 01, 2001
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Purpura: Thrombocytopenic
,
Thrombocytopenia
[+]
Melatonin may be effective in treating severe bleeding associated with refractory idiopathic thrombocytopenic purpura.
Mar 01, 2003
Click here to read the entire abstract
Pubmed Data
: Am J Ther. 2003 Mar-Apr;10(2):135-6. PMID:
12629593
Article Published Date
: Mar 01, 2003
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Purpura: Thrombocytopenic
,
Thrombocytopenia
[+]
Melatonin reduces muscle damage, inflammation and oxidative stress induced by exhaustive exercise in people with overweight/obesity.
Mar 02, 2022
Click here to read the entire abstract
Pubmed Data
: Physiol Int. 2022 Mar 3. Epub 2022 Mar 3. PMID:
35238798
Article Published Date
: Mar 02, 2022
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Muscle Damage: Exercise-Induced
,
Obesity
Therapeutic Actions
:
Exercise
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
Melatonin significantly improvement impaired sleep maintenance in children with Autism.
Jan 01, 2008
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2008 Jan;44(1):57-64. PMID:
18078449
Article Published Date
: Jan 01, 2008
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Autism
[+]
Melatonin significantly improves insomnia in patients aged 55 years or older.
Jan 01, 2000
Click here to read the entire abstract
Pubmed Data
: J Bone Miner Metab. 2000;18(4):216-22. PMID:
17875243
Article Published Date
: Jan 01, 2000
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Insomnia
[+]
Melatonin significantly reduced the risk of depressive symptoms in women with breast cancer during a three-month period after surgery.
May 31, 2014
Click here to read the entire abstract
Pubmed Data
: Breast Cancer Res Treat. 2014 Jun ;145(3):683-95. Epub 2014 Apr 23. PMID:
24756186
Article Published Date
: May 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Depression: Breast Cancer Related
Therapeutic Actions
:
Placebo Effect
Pharmacological Actions
:
Antidepressive Agents
[+]
Melatonin supplementation in diabetic diabetic hemodialysis patients had beneficial results.
Oct 05, 2019
Click here to read the entire abstract
Pubmed Data
: J Ren Nutr. 2019 Oct 6. Epub 2019 Oct 6. PMID:
31597622
Article Published Date
: Oct 05, 2019
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Hemodialysis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Hypoglycemic Agents
[+]
Melatonin supplementation is useful in treating H. pylori-associated dyspepsia.
Nov 25, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Womens Health. 2020 Nov 26 ;20(1):262. Epub 2020 Nov 26. PMID:
33243209
Article Published Date
: Nov 25, 2020
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Dyspepsia
,
Helicobacter Pylori Infection
Pharmacological Actions
:
Gastrointestinal Agents
[+]
Melatonin treatment is associated with significant nocturia response rate.
Mar 01, 2004
Click here to read the entire abstract
Pubmed Data
: J Urol. 2004 Mar;171(3):1199-202. PMID:
14767300
Article Published Date
: Mar 01, 2004
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Nocturia
[+]
Melatonin versus trazodone for the treatment of new onset insomnia.
Mar 31, 2023
Click here to read the entire abstract
Pubmed Data
: Hosp Pharm. 2023 Apr ;58(2):165-170. Epub 2022 Sep 8. PMID:
36890954
Article Published Date
: Mar 31, 2023
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Insomnia
Additional Keywords
:
Superiority of Natural Substances versus Drugs
[+]
Melatonin was superior to amitriptyline in the percentage of patients with a greater than 50% reduction in migraine frequency.
May 09, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Neurol Neurosurg Psychiatry. 2016 May 10. Epub 2016 May 10. PMID:
27165014
Article Published Date
: May 09, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Headache: Migraine
Pharmacological Actions
:
Prophylactic Agents
Additional Keywords
:
Superiority of Natural Substances versus Drugs
Problem Substances
:
Antidepressants
[+]
Melatonin, quercetin and NAC are beneficial in reducing oxidative stress in the patients with Grave's Disease.
Sep 01, 2005
Click here to read the entire abstract
Pubmed Data
: Pharmazie. 2005 Sep;60(9):696-700. PMID:
16222871
Article Published Date
: Sep 01, 2005
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
,
NAC (N-acetyl-L-cysteine)
,
Quercetin
Diseases
:
Graves Disease
Pharmacological Actions
:
Antioxidants
[+]
Mobile phone exposure may affect melatonin onset time.
Feb 01, 2006
Click here to read the entire abstract
Pubmed Data
: Int J Radiat Biol. 2006 Feb ;82(2):69-76. PMID:
16546905
Article Published Date
: Feb 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Sleep Disorders
Anti Therapeutic Actions
:
Electromagnetic Field Harms
,
Electromagnetic Radiation
,
Mobile Phone Radiation
Problem Substances
:
Cell Phone Exposure
Adverse Pharmacological Actions
:
Melatonin Interference
[+]
one-year treatment with melatonin increased bone mineral density at femoral neck in a dose-dependent manner, while high dose melatonin increased vBMD in the spine.
Jun 02, 2015
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2015 Jun 3. Epub 2015 Jun 3. PMID:
26036434
Article Published Date
: Jun 02, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bone Fractures
,
Osteopenia
,
Osteoporosis
Pharmacological Actions
:
Osteogenic
Additional Keywords
:
Dose Response
,
Significant Treatment Outcome
[+]
Overnight melatonin secretion was significantly higher after using a blue-light shield on self-luminous devices.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Chronobiol Int. 2016 ;33(1):134-9. Epub 2016 Jan 5. PMID:
26730983
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Circadian Dysregulation
,
Hormone Imbalances: Low Melatonin
Additional Keywords
:
Light Pollution
Anti Therapeutic Actions
:
Blue Light (400−495 nm)
[+]
Patients treated with melatonin-containing emulsion experienced significantly reduced radiation dermatitis.
Feb 29, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Isr Med Assoc J. 2016 Mar-Apr;18(3-4):188-92. PMID:
27228641
Article Published Date
: Feb 29, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chemotherapy and Radiation Toxicity
Additional Keywords
:
Risk Reduction
[+]
Patients treated with melatonin-containing emulsion experienced significantly reduced radiation dermatitis.
Feb 29, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Isr Med Assoc J. 2016 Mar-Apr;18(3-4):188-92. PMID:
27228641
Article Published Date
: Feb 29, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chemotherapy and Radiation Toxicity
Additional Keywords
:
Risk Reduction
[+]
Radiofrequency and temporally stable 60-Hz exposures were associated with increased estrogen metabolite excretion among postmenopausal women. Women with low nocturnal melatonin may be particularly susceptible.
Oct 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Occup Environ Med. 2007 Oct ;49(10):1149-56. PMID:
18000420
Article Published Date
: Oct 01, 2007
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Female
Additional Keywords
:
EMF
,
Estrogen Metabolism
,
Melatonin Production
Anti Therapeutic Actions
:
Electromagnetic Field Harms
,
Electromagnetic Radiation
[+]
Recommendations for the prevention of breast cancer in shift workers.
Nov 30, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: EPMA J. 2011 Dec ;2(4):351-6. Epub 2011 Dec 23. PMID:
23199173
Article Published Date
: Nov 30, 2011
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Breast Cancer
Anti Therapeutic Actions
:
Shift Work
[+]
Selected antioxidants have a protective effect against beta-cyfluthrin-induced oxidative stress in human erythrocytes in vitro.
Apr 01, 2010
Click here to read the entire abstract
Pubmed Data
: Toxicol In Vitro. 2010 Apr;24(3):879-84. Epub 2009 Dec 2. PMID:
19961921
Article Published Date
: Apr 01, 2010
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
,
Quercetin
,
Rutin
Diseases
:
Benzo[a]pyrene-induced Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Sleep deprivation may contribute to increased breast cancer risk.
Jan 31, 2013
Click here to read the entire abstract
Pubmed Data
: Gynecol Obstet Fertil. 2013 Feb ;41(2):105-9. Epub 2013 Feb 6. PMID:
23395427
Article Published Date
: Jan 31, 2013
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Breast Cancer
Anti Therapeutic Actions
:
Sleep Deprivation
[+]
Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.
Dec 31, 2012
Click here to read the entire abstract
Pubmed Data
: Neuro Endocrinol Lett. 2013 ;34(7):660-8. PMID:
24464005
Article Published Date
: Dec 31, 2012
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
,
Vitamin D
Diseases
:
Breast Cancer
,
Breast Cancer: Metastatic
,
Chemotherapy-Induced Toxicity: Cyclophosphamide
Additional Keywords
:
Natural Substance/Drug Synergy
,
Significant Treatment Outcome
[+]
Supplementation with beefsteak tomato before sleep can increase circulating melatonin and improve sleep quality in obese postmenopausal women.
Dec 31, 2019
Click here to read the entire abstract
Pubmed Data
: Clin Nutr. 2020 01 ;39(1):291-297. Epub 2019 Feb 10. PMID:
30792141
Article Published Date
: Dec 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
,
Tomato
Diseases
:
Obesity
,
Sleep Disorders
[+]
Supplementation with propolis and melatonin may improve clinical outcomes by reducing inflammation.
Feb 24, 2022
Click here to read the entire abstract
Pubmed Data
: Complement Med Res. 2022 Feb 25. Epub 2022 Feb 25. PMID:
35220312
Article Published Date
: Feb 24, 2022
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Pneumonia
,
Sepsis
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
The administration of melatonin with conventional treatment has reduced severe oral mucositis development.
Dec 22, 2019
Click here to read the entire abstract
Pubmed Data
: Oral Dis. 2019 Dec 23. Epub 2019 Dec 23. PMID:
31869853
Article Published Date
: Dec 22, 2019
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Oral Mucositis
Pharmacological Actions
:
Radioprotective
[+]
The data reflects a beneficial effect of melatonin treatment in resistance-training athletes.
Feb 12, 2017
Click here to read the entire abstract
Pubmed Data
: Appl Physiol Nutr Metab. 2017 Feb 13. Epub 2017 Feb 13. PMID:
28192673
Article Published Date
: Feb 12, 2017
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Muscle Damage: Exercise-Induced
Therapeutic Actions
:
Exercise: Resistance Training
Pharmacological Actions
:
Antioxidants
[+]
The effects of melatonin administration on carotid intima-media thickness and pulse wave velocity in diabetic nephropathy.
Dec 31, 2021
Click here to read the entire abstract
Pubmed Data
: Clin Nutr ESPEN. 2022 04 ;48:82-86. Epub 2022 Jan 6. PMID:
35331538
Article Published Date
: Dec 31, 2021
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Renoprotective
[+]
The prevalence of cognitive impairment and depressed mood decreased with increases in physiological melatonin levels in this study.
Jun 07, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Clin Endocrinol Metab. 2015 Jun 8:jc20151859. Epub 2015 Jun 8. PMID:
26052727
Article Published Date
: Jun 07, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Alzheimer's Disease
,
Cognitive Decline/Dysfunction
,
Depressive Disorder
Pharmacological Actions
:
Antidepressive Agents
,
Neuroprotective Agents
[+]
The results of this study showed that pre-operative melatonin administration could modify inflammatory cytokines secretion such as IL-6.
Feb 29, 2020
Click here to read the entire abstract
Pubmed Data
: Asian J Anesthesiol. 2020 Mar 1 ;58(1):35-44. Epub 2020 Mar 26. PMID:
33081432
Article Published Date
: Feb 29, 2020
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cardiac Surgery
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
[+]
These data support future studies evaluating the safety and effectiveness of melatonin supplementation in relapsing-remitting multiple sclerosis patients.
Dec 26, 2018
Click here to read the entire abstract
Pubmed Data
: Arch Med Res. 2018 Dec 27. Epub 2018 Dec 27. PMID:
30595364
Article Published Date
: Dec 26, 2018
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Multiple Sclerosis: Relapsing-Remitting
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
This pilot study shows promising results, in terms of headache frequency reduction and daily quality of life improvement.
Mar 07, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Funct Neurol. 2016 Mar 8:1-5. Epub 2016 Mar 8. PMID:
26954506
Article Published Date
: Mar 07, 2016
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Headache
Pharmacological Actions
:
Prophylactic Agents
Additional Keywords
:
Risk Reduction
[+]
This pilot study suggests that the combination of melatonin, vitamin B6, and medicinal plants may be beneficial in mild-to-moderate insomnia.
Jul 31, 2019
Click here to read the entire abstract
Pubmed Data
: Complement Ther Med. 2019 Aug ;45:104-108. Epub 2019 May 25. PMID:
31331545
Article Published Date
: Jul 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
Lemon Balm
,
Melatonin
,
Passion Flower
,
Poppy
,
Vitamin B-6
Diseases
:
Insomnia
Additional Keywords
:
Plant Extracts
[+]
This study hypothesized that the greater preservation of neurocognitive functions in the morning patients was associated with elevated melatonin levels.
May 24, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Ann Thorac Cardiovasc Surg. 2015 May 25. Epub 2015 May 25. PMID:
26004111
Article Published Date
: May 24, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Coronary Bypass Surgery
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
,
Vasodilator Agents
Additional Keywords
:
Significant Treatment Outcome
[+]
This suggests a possibly beneficial effect of melatonin on body composition and lipid metabolism as one year of treatment reduces fat mass and increases lean mass.
Sep 08, 2015
Click here to read the entire abstract
Pubmed Data
: Clin Endocrinol (Oxf). 2015 Sep 9. Epub 2015 Sep 9. PMID:
26352863
Article Published Date
: Sep 08, 2015
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Abdominal Obesity (Midsection Fat)
Pharmacological Actions
:
Adiponectin upregulation
[+]
Thymoquinone with metformin decreases fasting, post prandial glucose, and HbA1c in type 2 diabetic patients.
Mar 07, 2021
Click here to read the entire abstract
Pubmed Data
: Drug Res (Stuttg). 2021 Mar 8. Epub 2021 Mar 8. PMID:
33684953
Article Published Date
: Mar 07, 2021
Study Type
: Animal Study, Human Study
Additional Links
Substances
:
Melatonin
,
Thymoquinone
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Hypoglycemic Agents
[+]
Women with polycystic ovary syndrome have reduced melatonin concentrations in their follicles and have mild sleep disturbances.
Jan 20, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Womens Health. 2022 03 21 ;22(1):79. Epub 2022 Mar 21. PMID:
35313872
Article Published Date
: Jan 20, 2022
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Diseases
:
Hormone Imbalances: Low Melatonin
,
Polycystic Ovary Syndrome
[+]
Yogic practices can be used as psychophysiologic stimuli to increase endogenous secretion of melatonin, which, in turn, might be responsible for improved sense of well-being.
Apr 01, 2004
Click here to read the entire abstract
Pubmed Data
: J Altern Complement Med. 2004 Apr;10(2):261-8. PMID:
15165407
Article Published Date
: Apr 01, 2004
Study Type
: Human Study
Additional Links
Substances
:
Melatonin
Pharmacological Actions
:
Secretagogue
[+]
50 Hz electromagnetic fields stimulate superoxide radical anion formation in human K562 cells which is attentuated by melatonin.
Nov 01, 2010
Click here to read the entire abstract
Pubmed Data
: Radiat Environ Biophys. 2010 Nov ;49(4):731-41. Epub 2010 Jun 26. PMID:
20582429
Article Published Date
: Nov 01, 2010
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidants
Anti Therapeutic Actions
:
Electromagnetic Field Harms
,
Electromagnetic Radiation
Adverse Pharmacological Actions
:
Oxidant
[+]
Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion.
Jan 17, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Stem Cell Res Ther. 2019 10 17 ;10(1):306. Epub 2019 Oct 17. PMID:
31623678
Article Published Date
: Jan 17, 2019
Study Type
: Human In Vitro
Additional Links
Substances
:
Antioxidant formulas
,
Glutathione
,
Melatonin
Pharmacological Actions
:
Antioxidant
,
Regenerative
[+]
Dose-dependent DNA damage resulting from mobile phone radiation is attentuated by pretreatment with melatonin in vitro.
Nov 01, 2013
Click here to read the entire abstract
Pubmed Data
: Int J Radiat Biol. 2013 Nov ;89(11):993-1001. Epub 2013 Sep 3. PMID:
23952262
Article Published Date
: Nov 01, 2013
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
DNA damage
,
Infertility
,
Infertility: Male
,
Sperm Quality: Low
Pharmacological Actions
:
Genoprotective
,
Radioprotective
Additional Keywords
:
Cell Phones
,
electromagnetic fields
,
electromagnetic frequencies
,
electromagnetic radiation
,
EMF
,
male infertility
,
Male Infertility and Cellular Phones
Anti Therapeutic Actions
:
Electromagnetic Field Harms
,
Electromagnetic Radiation
,
Microwave Radiation
,
Mobile Phone Radiation
Problem Substances
:
Cell Phone Exposure
Adverse Pharmacological Actions
:
Genotoxic
[+]
Inhibition of ERK1/2 signalling pathway is involved in melatonin's antiproliferative effect on human MG-63 osteosarcoma cells.
Nov 06, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2016 Nov 7 ;39(6):2297-2307. Epub 2016 Aug 7. PMID:
27832629
Article Published Date
: Nov 06, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Antiproliferative
[+]
Melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis.
Feb 13, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: World J Gastroenterol. 2017 Feb 14 ;23(6):986-998. PMID:
28246472
Article Published Date
: Feb 13, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Apoptotic
,
Cyclooxygenase 2 Inhibitors
[+]
Melatonin has anti-angiogenic effects at different steps of the angiogenic process in SH-SY5Y neuroblastoma cells.
Feb 13, 2017
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2017 Feb 14. Epub 2017 Feb 14. PMID:
28259965
Article Published Date
: Feb 13, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Neuroblastoma
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Melatonin has prospects for treating osteoporosis caused by inflammatory factors.
Jun 05, 2016
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2016 Jun 6. Epub 2016 Jun 6. PMID:
27265199
Article Published Date
: Jun 05, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Inflammation
,
Osteoporosis: Inflammation Induced
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Osteogenic
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin in combination with HDAC inhibitors may be a novel therapeutic intervention for human lung adenocarcinoma.
Jul 15, 2015
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2015 Jul 16. Epub 2015 Jul 16. PMID:
26184924
Article Published Date
: Jul 15, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
[+]
Melatonin in combination with sorafenib synergistically inhibits proliferation and induces apoptosis in human liver cancer cells.
Feb 07, 2017
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2017 Feb 8. Epub 2017 Feb 8. PMID:
28178378
Article Published Date
: Feb 07, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemosensitizer
Additional Keywords
:
Chemothapeutic Synergy: Sorafenib
,
Dose Response
[+]
Melatonin is a potential candidate compound for the treatment of proinflammatory disorders.
Aug 31, 2012
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2012 Sep ;53(2):154-65. Epub 2012 Feb 21. PMID:
22348531
Article Published Date
: Aug 31, 2012
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
,
Prostaglandin PGE2 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Dose Response
[+]
Melatonin promotes the BMP9-induced osteogenic differentiation of mesenchymal stem cells by activating the AMPK/β-catenin signalling pathway.
Dec 21, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Stem Cell Res Ther. 2019 Dec 21 ;10(1):408. Epub 2019 Dec 21. PMID:
31864412
Article Published Date
: Dec 21, 2019
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Pharmacological Actions
:
Regenerative
Additional Keywords
:
Bone Regeneration
[+]
These results show that breast cancer stem cells, in both a canine and a human cell lines are responsive to melatonin treatment.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016 ;11(3):e0150407. Epub 2016 Mar 2. PMID:
26934679
Article Published Date
: Dec 31, 2015
Study Type
: Human In Vitro, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Breast Cancer
,
Cancer Metastasis
Pharmacological Actions
:
Anti-metastatic
Additional Keywords
:
Cancer Stem Cells
[+]
This study confirms the role of melatonin in enhancing the biological activities of adipose-derived stem cells.
Dec 01, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Med. 2019 Dec ;44(6):2234-2244. Epub 2019 Sep 27. PMID:
31573052
Article Published Date
: Dec 01, 2019
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Pharmacological Actions
:
Regenerative
[+]
Melatonin attenuates bisphenol A-induced colon injury.
Jan 31, 2023
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2023 Feb 1 ;195:13-22. Epub 2022 Dec 19. PMID:
36549428
Article Published Date
: Jan 31, 2023
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bisphenol Toxicity
Pharmacological Actions
:
Antioxidants
,
Gastroprotective
,
Nrf2 activation
Problem Substances
:
Bisphenol A
Adverse Pharmacological Actions
:
Gastrotoxic
[+]
Melatonin ameliorates microvessel abnormalities in the cerebral cortex and hippocampus in a model of Alzheimer's disease.
Mar 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Neural Regen Res. 2021 Apr ;16(4):757-764. PMID:
33063739
Article Published Date
: Mar 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Melatonin Reduces alcohol drinking in rats with disrupted function of the serotonergic system.
Feb 25, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Pers Med. 2022 Feb 26 ;12(3). Epub 2022 Feb 26. PMID:
35330355
Article Published Date
: Feb 25, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Alcohol Toxicity
,
Sleep Disorders
[+]
Oral administration of melatonin contained in drinking water increased bone strength in naturally aged mice.
Aug 31, 2020
Click here to read the entire abstract
Pubmed Data
: Acta Histochem. 2020 Sep ;122(6):151596. Epub 2020 Jul 18. PMID:
32778234
Article Published Date
: Aug 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bone Diseases
,
Osteoporosis
Pharmacological Actions
:
Osteoprotective
[+]
1800-MHz radiofrequency fields disturb plasma melatonin levels in rats.
Jan 01, 2012
Click here to read the entire abstract
Pubmed Data
: J Toxicol Environ Health A. 2012 ;75(18):1120-8. PMID:
22891885
Article Published Date
: Jan 01, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Testosterone
Anti Therapeutic Actions
:
Electromagnetic Field Harms
,
Electromagnetic Radiation
Adverse Pharmacological Actions
:
Endocrine Disruptor
,
Melatonin Interference
[+]
900 MHz EMF induced mild skin changes that were attentuated by melatonin.
Sep 01, 2004
Click here to read the entire abstract
Pubmed Data
: Toxicol Ind Health. 2004 Sep ;20(6-10):133-9. PMID:
15941010
Article Published Date
: Sep 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Radiation Induced Illness
Pharmacological Actions
:
Antioxidants
Anti Therapeutic Actions
:
Electromagnetic Field Harms
,
Electromagnetic Radiation
[+]
A ketogenic diet combined with melatonin overcomes cisplatin and vincristine drug resistance in breast carcinoma syngraft.
Nov 26, 2019
Click here to read the entire abstract
Pubmed Data
: Nutrition. 2019 Nov 27 ;72:110659. Epub 2019 Nov 27. PMID:
31986320
Article Published Date
: Nov 26, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Breast Cancer
Therapeutic Actions
:
Dietary Modification: Low Carbohydrate/Ketogenic
Additional Keywords
:
Chemotherapeutic Synergy: Cisplatin
,
Natural Substance Synergy
[+]
Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.
Mar 01, 2017
Click here to read the entire abstract
Pubmed Data
: Biofactors. 2017 Mar ;43(2):272-282. Epub 2016 Nov 1. PMID:
27801960
Article Published Date
: Mar 01, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Liver Cirrhosis
Pharmacological Actions
:
Anti-Fibrotic
Additional Keywords
:
Liver Regeneration
[+]
Activity of melatonin against gastric cancer growth.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Manag Res. 2021 ;13:8803-8808. Epub 2021 Nov 24. PMID:
34853535
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Antiproliferative
[+]
Administration of melatonin and vitamin C as radioprotectors before irradiation may reduce genotoxicity caused by x-ray irradiation.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell J. 2016 ;18(1):46-51. Epub 2016 Apr 4. PMID:
27054118
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Vitamin C
Diseases
:
Chemotherapy and Radiation Toxicity
Pharmacological Actions
:
Radioprotective
Additional Keywords
:
Natural Substance Synergy
Anti Therapeutic Actions
:
Radiotherapy
[+]
Administration of melatonin, retinoic acid and Nigella sativa reduced the carcinogenic effects of DMBA.
Nov 30, 2005
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Exp Pathol. 2005 Dec ;86(6):383-96. PMID:
16309544
Article Published Date
: Nov 30, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Nigella sativa (aka Black Seed)
,
Vitamin A
Diseases
:
Breast Cancer
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Anticarcinogenic Agents
Additional Keywords
:
Metabolites
,
Phytotherapy
,
Plant Extracts
[+]
Administration of N-acetylserotonin and melatonin alleviate chronic ketamine-induced behavioural phenotype .
Oct 12, 2015
Click here to read the entire abstract
Pubmed Data
: Behav Brain Res. 2015 Oct 13. Epub 2015 Oct 13. PMID:
26475510
Article Published Date
: Oct 12, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Psychiatric Disorders
Pharmacological Actions
:
Cytoprotective
,
Neuroprotective Agents
[+]
Affron® supplementation reduces kynurenine levels and promotes melatonin synthesis.
Aug 15, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Antioxidants (Basel). 2023 Aug 16 ;12(8). Epub 2023 Aug 16. PMID:
37627614
Article Published Date
: Aug 15, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Saffron
Diseases
:
Sleep Disorders
[+]
Aluminum chloride-induced amyloid β accumulation and endoplasmic reticulum stress in rat brain are averted by melatonin.
Oct 28, 2020
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2020 Oct 29 ;146:111829. Epub 2020 Oct 29. PMID:
33130240
Article Published Date
: Oct 28, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aluminum Toxicity
,
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
Problem Substances
:
Aluminum Chloride
[+]
Amelioratory effect of melatonin on cognition dysfunction induced by sevoflurane anesthesia.
Nov 30, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran J Pharm Res. 2022 Dec ;21(1):e133971. Epub 2023 Jan 24. PMID:
36896324
Article Published Date
: Nov 30, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cognitive Decline/Dysfunction
,
Surgery: Anesthesiology
Pharmacological Actions
:
Neuroprotective Agents
[+]
Anti-apoptosis and autophagy effects of melatonin protect rat chondrocytes.
Jan 11, 2021
Click here to read the entire abstract
Pubmed Data
: Cartilage. 2021 12 ;13(2_suppl):1041S-1053S. Epub 2021 Nov 15. PMID:
34775836
Article Published Date
: Jan 11, 2021
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Anti-Apoptotic
,
Chondroprotective
[+]
Anti-inflammatory effects of melatonin in rats with induced type 2 diabetes mellitus.
Apr 11, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Life (Basel). 2022 Apr 12 ;12(4). Epub 2022 Apr 12. PMID:
35455066
Article Published Date
: Apr 11, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Antivenom administered along with melatonin not only offered 100% survival of experimental mice, but significantly reduced methemoglobin levels, and oxidative stress markers.
Jun 22, 2015
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2015 Jun 23. Epub 2015 Jun 23. PMID:
26103459
Article Published Date
: Jun 22, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Oxidative Stress
,
Snake Bite: Venom Toxicity
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Risk Reduction
,
Significant Treatment Outcome
[+]
Cardioprotection induced by melatonin is mediated by TLR4 to activate the SAFE pathway.
Oct 13, 2015
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2015 Oct 14. Epub 2015 Oct 14. PMID:
26465095
Article Published Date
: Oct 13, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Cardioprotective
[+]
Chronobiotic effect of melatonin in experimental optic neuritis.
Nov 12, 2020
Click here to read the entire abstract
Pubmed Data
: Neuropharmacology. 2020 Nov 13 ;182:108401. Epub 2020 Nov 13. PMID:
33197466
Article Published Date
: Nov 12, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Optic Neuritis
Additional Keywords
:
Chronobiotic
[+]
Co-administration of melatonin and resveratrol can be beneficial in BCCAO-induced vascular dementia.
Apr 18, 2017
Click here to read the entire abstract
Pubmed Data
: Neuroimmunomodulation. 2017 Apr 19. Epub 2017 Apr 19. PMID:
28419991
Article Published Date
: Apr 18, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Resveratrol
Diseases
:
Dementia
Pharmacological Actions
:
Neuroprotective Agents
[+]
Co-administration of melatonin mitigated chemotherapy induced testicular dysfunction.
Jun 14, 2015
Click here to read the entire abstract
Pubmed Data
: Drug Chem Toxicol. 2015 Jun 15:1-10. Epub 2015 Jun 15. PMID:
26072956
Article Published Date
: Jun 14, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chemotherapy-Induced Toxicity
Pharmacological Actions
:
Antioxidants
,
Chemoprotective Agents
,
Superoxide Dismutase Up-regulation
[+]
Combination of Vit D3 and melatonin may reduce seizure frequency in epileptic patients.
Apr 28, 2022
Click here to read the entire abstract
Pubmed Data
: Cent Nerv Syst Agents Med Chem. 2022 Apr 29. Epub 2022 Apr 29. PMID:
35507790
Article Published Date
: Apr 28, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Vitamin D
Diseases
:
Epilepsy
Pharmacological Actions
:
Anticonvulsants
[+]
Comparative protective effects of N-acetylcysteine, and melatonin against obesity-induced testicular dysfunction.
Nov 16, 2020
Click here to read the entire abstract
Pubmed Data
: Can J Physiol Pharmacol. 2020 Nov 17. Epub 2020 Nov 17. PMID:
33201734
Article Published Date
: Nov 16, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
NAC (N-acetyl-L-cysteine)
Diseases
:
Obesity
,
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticholesteremic Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Comparison of the effects of electroacupuncture and melatonin on nerve regeneration in experimentally nerve-damage.
Oct 30, 2021
Click here to read the entire abstract
Pubmed Data
: J Acupunct Meridian Stud. 2021 Oct 31 ;14(5):176-182. PMID:
35770586
Article Published Date
: Oct 30, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Sciatica
Therapeutic Actions
:
Electroacupuncture
Pharmacological Actions
:
Neuroprotective Agents
,
Regenerative
Additional Keywords
:
Nerve Regeneration
[+]
Curcumin, resveratrol and melatonin protect against cadmium-induced oxidative damage.
Aug 15, 2006
Click here to read the entire abstract
Pubmed Data
: Toxicology. 2006 Aug 15;225(2-3):150-6. Epub 2006 May 26. PMID:
16806632
Article Published Date
: Aug 15, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Melatonin
,
Resveratrol
Diseases
:
Cadmium Poisoning
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Stilbenes
[+]
Data support the use of melatonin in therapeutic interventions to reduce brain damage induced by leptin deficiency-dependent obesity.
Oct 29, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Neurobiol. 2017 Oct 30. Epub 2017 Oct 30. PMID:
29086246
Article Published Date
: Oct 29, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Obesity
Pharmacological Actions
:
Neuroprotective Agents
[+]
Daytime blue light enhances the nighttime circadian melatonin inhibition of human prostate cancer growth.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Comp Med. 2015 ;65(6):473-85. PMID:
26678364
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Prostate Cancer
Therapeutic Actions
:
Light Therapy
Pharmacological Actions
:
Antiproliferative
[+]
Dietary melatonin supplementation may have beneficial effects in the management of metabolic syndrome.
Oct 08, 2019
Click here to read the entire abstract
Pubmed Data
: Endocr Metab Immune Disord Drug Targets. 2019 Oct 9. Epub 2019 Oct 9. PMID:
32138638
Article Published Date
: Oct 08, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
High Fat Diet
,
High Sugar Diet
Pharmacological Actions
:
Antioxidants
[+]
Dietary melatonin supplementation might limit obesogenic changes in the heart and preserve mitochondrial size and membranes.
Dec 04, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2017 Dec 5 ;9(12). Epub 2017 Dec 5. PMID:
29206172
Article Published Date
: Dec 04, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Obesity
,
Prediabetes
Pharmacological Actions
:
Cardioprotective
[+]
Early treatment of acute myocardial infarction with melatonin.
Mar 29, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Clin Med. 2022 Mar 30 ;11(7). Epub 2022 Mar 30. PMID:
35407517
Article Published Date
: Mar 29, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Myocardial Infarction
Pharmacological Actions
:
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Echinacea purpurea and melatonin augment natural-killer cells in leukemic mice and prolong life span.
Jun 01, 2001
Click here to read the entire abstract
Pubmed Data
: J Altern Complement Med. 2001 Jun;7(3):241-51. PMID:
11439845
Article Published Date
: Jun 01, 2001
Study Type
: Animal Study
Additional Links
Substances
:
Echinacea
,
Melatonin
Diseases
:
Immune Disorders: Low Immune Function
,
Leukemia
,
Low Immune Function: Natural Killer Cells
Pharmacological Actions
:
Immunomodulatory
[+]
Effect of concomitant treatment of curcumin and melatonin on cisplatin-induced nephrotoxicity.
Oct 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Pharmacother. 2020 Nov ;131:110761. Epub 2020 Sep 19. PMID:
33152924
Article Published Date
: Oct 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Melatonin
Diseases
:
Chemotherapy-Induced Kidney Damage
,
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Chemoprotective Agents
,
Renoprotective
[+]
Effects of melatonin and N-acetylcysteine on aluminum phosphide poisoning.
Jul 31, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: J Family Med Prim Care. 2022 Aug ;11(8):4500-4504. Epub 2022 Aug 30. PMID:
36352994
Article Published Date
: Jul 31, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
NAC (N-acetyl-L-cysteine)
Diseases
:
Aluminum Toxicity
,
Chemically-Induced Liver Damage
Pharmacological Actions
:
Hepatoprotective
Problem Substances
:
Aluminum
[+]
Effects of melatonin on cardiac metabolic reprogramming in doxorubicin-induced heart failure.
Jul 31, 2023
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2023 Aug ;75(1):e12884. Epub 2023 May 22. PMID:
37177873
Article Published Date
: Jul 31, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
,
Heart Failure
Pharmacological Actions
:
Cardioprotective
,
Chemoprotective Agents
[+]
Efficacy of melatonin in restoring the antioxidant status in the lens of diabetic rats induced by streptozotocin.
Nov 30, 2019
Click here to read the entire abstract
Pubmed Data
: J Diabetes Metab Disord. 2019 Dec ;18(2):543-549. Epub 2019 Dec 2. PMID:
31890680
Article Published Date
: Nov 30, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Antioxidants
,
Hypoglycemic Agents
[+]
Electromagnetic fields may interfere with melatonin synthesis in a season-dependent manner.
Sep 18, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2015 Sep 18 ;5:14206. Epub 2015 Sep 18. PMID:
26381579
Article Published Date
: Sep 18, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Additional Keywords
:
Radio Frequency Electromagnetic Radiation Exposure
Anti Therapeutic Actions
:
Electromagnetic Field Harms
Adverse Pharmacological Actions
:
Melatonin Interference
[+]
Emerging evidence further suggests the protective benefits of melatonin against BPA nephrotoxicity.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2018 ;2018:3082438. Epub 2018 Feb 18. PMID:
29670679
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bisphenol Toxicity
Pharmacological Actions
:
Antioxidants
,
Renoprotective
Problem Substances
:
Bisphenol A
[+]
Fertility outcomes can be improved by melatonin it enhances progesterone receptor expression.
Mar 31, 2018
Click here to read the entire abstract
Pubmed Data
: Cell J. 2018 Apr ;20(1):108-112. Epub 2017 Dec 1. PMID:
29308626
Article Published Date
: Mar 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Infertility
Pharmacological Actions
:
Fertility Agents
[+]
First evidence of the protective role of melatonin in counteracting cadmium toxicity in the rat ovary.
Nov 08, 2020
Click here to read the entire abstract
Pubmed Data
: Environ Pollut. 2020 Nov 9:116056. Epub 2020 Nov 9. PMID:
33199064
Article Published Date
: Nov 08, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cadmium Poisoning
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
Problem Substances
:
Cadmium
[+]
Folic acid and melatonin mitigate diabetic nephropathy in rats via inhibition of oxidative stress.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Nutr Metab (Lond). 2020 ;17:6. Epub 2020 Jan 14. PMID:
31956332
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Folic Acid
,
Melatonin
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Renoprotective
[+]
Grape seed proanthocyanidin extract treatment maintained nocturnal melatonin levels and altered the oscillations of some metabolites in plasma.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2015 May ;59(5):865-78. Epub 2015 Mar 23. PMID:
25677201
Article Published Date
: Apr 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Grape Seed Extract
,
Melatonin
,
Proanthocyanidins
Diseases
:
Circadian Dysregulation
Additional Keywords
:
Chronobiotic
,
Circadian Clock Proteins
,
Plant Extracts
[+]
Inhibition of Interleukin-33 with Melatonin provides therapeutic potential in diabetic kidney disease with contrast-induced nephropathy.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mediators Inflamm. 2016 ;2016:9050828. Epub 2016 Feb 18. PMID:
26989334
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Diabetic Nephropathy
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
Ischemic stroke, obesity, and the anti-inflammatory role of melatonin.
Nov 01, 2020
Click here to read the entire abstract
Pubmed Data
: Biofactors. 2020 Nov 2:e1690. Epub 2020 Nov 2. PMID:
33135223
Article Published Date
: Nov 01, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Obesity
,
Stroke: Ischemic
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
iTRAQ-based quantitative proteomics analysis of the hepatoprotective effect of melatonin on ANIT-induced cholestasis in rats.
Aug 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2021 Sep ;22(3):1014. Epub 2021 Jul 15. PMID:
34373700
Article Published Date
: Aug 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Liver Damage
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
[+]
Kidney bean sprouts could be a good source of dietary melatonin and other bioactive compounds known to have health benefits.
Feb 29, 2016
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2016 Mar ;7(3):1438-45. PMID:
26841704
Article Published Date
: Feb 29, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Beans: All
,
Melatonin
Diseases
:
Hormone Imbalances: Low Melatonin
Pharmacological Actions
:
Antioxidants
[+]
Lycopene alone and combined with melatonin provided significant improvement against renal damage caused by methotrexate.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
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Click here to read the complete article.
Pubmed Data
: Asian Pac J Cancer Prev. 2015 ;16(14):6061-6. PMID:
26320496
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Lycopene
,
Melatonin
Diseases
:
Drug-Induced Toxicity: Methotrexate
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Renoprotective
[+]
Magnetic fields induce morphological changes in the rat liver which to which melatonin has a mild protective effect.
May 01, 2002
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Okajimas Folia Anat Jpn. 2002 May ;79(1):25-31. PMID:
12199535
Article Published Date
: May 01, 2002
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Pharmacological Actions
:
Radioprotective
Anti Therapeutic Actions
:
Electromagnetic Field Harms
,
Electromagnetic Radiation
Adverse Pharmacological Actions
:
Cytotoxic
,
Hepatotoxic
[+]
Melatonin abated bisphenol A-induced neurotoxicity via p53/PUMA/Drp-1 signaling.
Jan 04, 2021
Click here to read the entire abstract
Pubmed Data
: Environ Sci Pollut Res Int. 2021 Jan 5. Epub 2021 Jan 5. PMID:
33398767
Article Published Date
: Jan 04, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bisphenol Toxicity
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
Problem Substances
:
Bisphenol A
[+]
Melatonin administration could alleviate the burden of Alzheimer's disease and may be considered a promising pharmaceutical treatment of the disease.
Jul 08, 2015
Click here to read the entire abstract
Pubmed Data
: J Alzheimers Dis. 2015 Jul 9 ;47(1):103-16. PMID:
26402759
Article Published Date
: Jul 08, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Melatonin administration may lower the risk of relapse triggered by cues in cocaine-experienced animals.
Feb 27, 2017
Click here to read the entire abstract
Pubmed Data
: Psychopharmacology (Berl). 2017 Feb 28. Epub 2017 Feb 28. PMID:
28246896
Article Published Date
: Feb 27, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cocaine Addiction
,
Cocaine Withdrawal
Additional Keywords
:
Cocaine Addiction
,
Cocaine Withdrawal
,
melatonin
[+]
Melatonin administration significantly reduces the apoptotic index occurring after acute unilateral ureteral obstruction.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Cent European J Urol. 2016 ;69(2):225-30. Epub 2016 Jun 20. PMID:
27551563
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Obstructive Nephropathy
Pharmacological Actions
:
Anti-Apoptotic
,
Renoprotective
[+]
Melatonin alleviated acrylamide induced lipid peroxidation and depressed antioxidant capacity.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2015;2015:703709. Epub 2015 Jun 21. PMID:
26185593
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Acrylamide-induced toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Chemopreventive
Additional Keywords
:
Risk Reduction
Problem Substances
:
Acrylamide
[+]
Melatonin alleviated fluoride-induced impairment of spermatogenesis and sperm maturation process.
Jul 31, 2023
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2023 Aug ;178:113867. Epub 2023 Jun 1. PMID:
37269891
Article Published Date
: Jul 31, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Fluoride Toxicity
,
Infertility: Male
Pharmacological Actions
:
Fertility Agents: Male
Additional Keywords
:
Gene Expression Regulation
Problem Substances
:
Sodium Fluoride
[+]
Melatonin alleviated the distortion of normal hepatic architecture, lowering the incidence of preneoplastic and neoplastic lesions.
Sep 30, 2016
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2016 Oct 1. Epub 2016 Aug 1. PMID:
27696512
Article Published Date
: Sep 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
Additional Keywords
:
Risk Reduction
[+]
Melatonin alleviates aluminium chloride-induced immunotoxicity.
May 29, 2019
Click here to read the entire abstract
Pubmed Data
: Ecotoxicol Environ Saf. 2019 May 30 ;173:131-141. Epub 2019 Feb 13. PMID:
30771656
Article Published Date
: May 29, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aluminum Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Nrf2 activation
Problem Substances
:
Aluminum Chloride
[+]
Melatonin alleviates angiotensin-II-induced cardiac hypertrophy via activating MICU1 pathway.
Nov 25, 2020
Click here to read the entire abstract
Pubmed Data
: Aging (Albany NY). 2020 Nov 26 ;12. Epub 2020 Nov 26. PMID:
33259334
Article Published Date
: Nov 25, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cardiac Hypertrophy
Pharmacological Actions
:
Cardioprotective
[+]
Melatonin alleviates insulin resistance through the PI3K/AKT signaling pathway in ovary granulosa cells of polycystic ovary syndrome.
Dec 21, 2021
Click here to read the entire abstract
Pubmed Data
: Reprod Biol. 2021 Dec 22 ;22(1):100594. Epub 2021 Dec 22. PMID:
34953312
Article Published Date
: Dec 21, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Insulin Resistance
,
Polycystic Ovary Syndrome
[+]
Melatonin alleviates lipopolysaccharide induced blood-brain barrier disruption.
Feb 02, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Aging Cell. 2017 Feb 3. Epub 2017 Feb 3. PMID:
28156052
Article Published Date
: Feb 02, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Blood Brain Barrier
[+]
Melatonin alleviates lung injury in H1N1-infected mice by mast cell inactivation and cytokine storm suppression.
Apr 30, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS Pathog. 2023 May ;19(5):e1011406. Epub 2023 May 18. PMID:
37200384
Article Published Date
: Apr 30, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Influenza
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Immunomodulatory
Additional Keywords
:
Cytokine Storm
[+]
Melatonin alleviates neonatal necrotizing enterocolitis.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Gastroenterol Res Pract. 2022 ;2022:6920577. Epub 2022 Mar 17. PMID:
35340691
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Necrotising enterocolitis
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Melatonin alleviates pyroptosis of retinal neurons following acute intraocular hypertension.
Oct 11, 2020
Click here to read the entire abstract
Pubmed Data
: CNS Neurol Disord Drug Targets. 2020 Oct 12. Epub 2020 Oct 12. PMID:
33045971
Article Published Date
: Oct 11, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Hypertension
Pharmacological Actions
:
Anti-Apoptotic
[+]
Melatonin alleviates traumatic brain injury-induced anxiety-like behaviors.
Mar 31, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2022 Apr ;23(4):248. Epub 2022 Jan 31. PMID:
35261620
Article Published Date
: Mar 31, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Anxiety
,
Traumatic Brain Injury
Pharmacological Actions
:
Anti-Anxiety Agents
[+]
Melatonin ameliorated CUMS-induced depression-like behavior via restoring endoplasmic reticulum stress in rat hippocampus.
Nov 04, 2020
Click here to read the entire abstract
Pubmed Data
: Neuroreport. 2020 Nov 5. Epub 2020 Nov 5. PMID:
33165196
Article Published Date
: Nov 04, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
[+]
Melatonin ameliorated sodium fluoride-induced testicular metabolic stress.
Dec 10, 2019
Click here to read the entire abstract
Pubmed Data
: Biol Trace Elem Res. 2019 Dec 11. Epub 2019 Dec 11. PMID:
31828722
Article Published Date
: Dec 10, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Heme oxygenase-1 up-regulation
,
NF-kappaB Inhibitor
,
Nrf2 activation
Problem Substances
:
Sodium Fluoride
[+]
Melatonin ameliorates atherosclerosis by suppressing S100a9-mediated vascular inflammation.
Aug 22, 2023
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2023 Aug 23 ;957:175965. Epub 2023 Aug 23. PMID:
37625682
Article Published Date
: Aug 22, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Anti-atherogenic
[+]
Melatonin ameliorates bisphenol A-induced perturbations of the prostate gland of adult Wistar rats.
May 25, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 May 26 ;105:73-82. Epub 2018 May 26. PMID:
29843047
Article Published Date
: May 25, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bisphenol Toxicity
Pharmacological Actions
:
Cytoprotective
Problem Substances
:
Bisphenol A
[+]
Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation.
Dec 14, 2019
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2019 Dec 15 ;239:117036. Epub 2019 Nov 4. PMID:
31697951
Article Published Date
: Dec 14, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Neuroprotective Agents
[+]
Melatonin ameliorates diquat-induced testicular toxicity.
Feb 07, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Toxics. 2023 Feb 8 ;11(2). Epub 2023 Feb 8. PMID:
36851035
Article Published Date
: Feb 07, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Pesticide Toxicity
,
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
[+]
Melatonin ameliorates low-grade inflammation and oxidative stress in young diabetic fatty rats.
Aug 22, 2012
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2012 Aug 23. Epub 2012 Aug 23. PMID:
23020082
Article Published Date
: Aug 22, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Diabetes Mellitus: Type 2
,
Inflammation
,
Insulin Resistance
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Melatonin ameliorates neural function by promoting endogenous neurogenesis in ischemic stroke mice.
Feb 10, 2012
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2012 Feb 10. Epub 2012 Feb 10. PMID:
22330064
Article Published Date
: Feb 10, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Stroke: Ischemic
Pharmacological Actions
:
Neuroprotective Agents
[+]
Melatonin ameliorates renal dysfunction in glyphosate- and hard water-treated mice.
Jul 31, 2022
Click here to read the entire abstract
Pubmed Data
: Ecotoxicol Environ Saf. 2022 Aug ;241:113803. Epub 2022 Jun 29. PMID:
36068739
Article Published Date
: Jul 31, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Glyphosate Toxicity
,
Kidney Damage: Chemically-Induced
Pharmacological Actions
:
Renoprotective
Problem Substances
:
Glyphosate
[+]
Melatonin ameliorates symptoms of kidney damage in rats.
Nov 01, 2005
Click here to read the entire abstract
Pubmed Data
: Zhonghua Zhong Liu Za Zhi. 2005 Nov;27(11):667-71. PMID:
18077597
Article Published Date
: Nov 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Kidney Diseases
,
Kidney Failure
[+]
Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer's disease.
May 08, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Transl Neurodegener. 2022 May 9 ;11(1):27. Epub 2022 May 9. PMID:
35527277
Article Published Date
: May 08, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
MicroRNA modulator
,
Neuroprotective Agents
[+]
Melatonin ameliorates testicular damages induced by nicotine in mice.
May 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran J Basic Med Sci. 2018 Jun ;21(6):639-644. PMID:
29942456
Article Published Date
: May 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Testicular Injury: Nicotine-Induced
Pharmacological Actions
:
Anti-Apoptotic
[+]
Melatonin ameliorates the drug induced nephrotoxicity.
Nov 13, 2019
Click here to read the entire abstract
Pubmed Data
: Nefrologia. 2019 Nov 14. Epub 2019 Nov 14. PMID:
31735377
Article Published Date
: Nov 13, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Kidney Damage: Drug-Induced
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
,
Renoprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin and a compound found within bee propolis have a protective effect against electromagnetic radiation-induced retinal oxidative stress associated with long-term mobile phone exposure.
Jan 01, 2006
Click here to read the entire abstract
Pubmed Data
: : Mol Cell Biochem. 2006 Jan;282(1-2):83-8. PMID:
16317515
Article Published Date
: Jan 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Bee Propolis
,
Melatonin
Diseases
:
Electromagnetic Radiation Mitigation
,
Mobile Phone-Induced Oxidative Stress
[+]
Melatonin and andrographolide synergize to inhibit the colospheroid phenotype by targeting Wnt/beta-catenin signaling.
May 25, 2022
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2022 May 26:e12808. Epub 2022 May 26. PMID:
35619550
Article Published Date
: May 25, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Andrographolide
,
Melatonin
Diseases
:
Colon Cancer
Pharmacological Actions
:
Apoptotic
,
Cyclin D1 Down-Regulation
,
Wnt/β-catenin signaling pathway modulation
[+]
Melatonin and buffalo pineal proteins attenuate flouride-induced oxidative stress in the rat brain.
Nov 01, 2000
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2000 Nov;48(11):5630-9. PMID:
19159082
Article Published Date
: Nov 01, 2000
Study Type
: Animal Study
Additional Links
Substances
:
Glandulars
,
Melatonin
Diseases
:
Fluoride Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
Melatonin and caffeic acid phenethyl ester prevent renal tubular injury by reducing oxidative stress and protect the kidney from oxidative damage induced by 900 MHz mobile phone.
Aug 01, 2005
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2005 Aug ;276(1-2):31-7. PMID:
16132682
Article Published Date
: Aug 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Caffeic acid phenethyl ester
,
Melatonin
Diseases
:
Radiation Induced Illness
Pharmacological Actions
:
Antioxidants
,
Malondialdehyde Down-regulation
,
Superoxide Dismutase Up-regulation
Anti Therapeutic Actions
:
Electromagnetic Field Harms
,
Electromagnetic Radiation
Adverse Pharmacological Actions
:
Nephrotoxic
[+]
Melatonin and coenzyme Q ameliorated most of the impaired fatty acid profile in rodent model with persistent autistic features.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Food Nutr Res. 2016 ;60:28127. Epub 2016 Mar 3. PMID:
26945230
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Coenzyme Q10
,
Melatonin
Diseases
:
Autism
Additional Keywords
:
Gut-brain Axis
[+]
Melatonin and curcumin protect against ndomethacin-induced acute gastric ulceration.
Sep 15, 2006
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2006 Sep 15;41(6):911-25. Epub 2006 Apr 30. PMID:
16934674
Article Published Date
: Sep 15, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Melatonin
Diseases
:
Drug-Induced Toxicity: Indomethacin
,
Gastric Ulcer
Pharmacological Actions
:
Antioxidants
,
Gastroprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Drug: Indomethacin
[+]
Melatonin and omega-3 can protect cells against neuronal damage in the hippocampus induced by 900 MHz EMF.
Jul 20, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Radiat Biol. 2016 Jul 21:1-6. Epub 2016 Jul 21. PMID:
27442260
Article Published Date
: Jul 20, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Omega-3 Fatty Acids
Pharmacological Actions
:
Neuroprotective Agents
Anti Therapeutic Actions
:
Electromagnetic Field Harms
[+]
Melatonin and probiotics ameliorate nanoplastics-induced hematopoietic injury.
Nov 14, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nano Res. 2022 Nov 15 ;16(2):2885-2894. PMID:
37207041
Article Published Date
: Nov 14, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Blood Diseases
Pharmacological Actions
:
Gastrointestinal Agents
Additional Keywords
:
Microplastic
Problem Substances
:
Nanoparticles
[+]
Melatonin and pycnogenol have a therapeutic role in the treatment fo endothelial dysfunction.
Aug 01, 2003
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2003 Aug;12(2):269-73. PMID:
20421515
Article Published Date
: Aug 01, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids
,
Melatonin
Diseases
:
Endothelial Dysfunction
,
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Melatonin and resveratrol, as found in red wine, protect the heart in an experimental model of myocardial infarction.
Feb 23, 2011
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2011 Feb 23. Epub 2011 Feb 23. PMID:
21342247
Article Published Date
: Feb 23, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Resveratrol
,
Wine
Diseases
:
Myocardial Infarction
,
Myocardial Ischemia
Pharmacological Actions
:
Cardioprotective
[+]
Melatonin and selenium induced protective effects against diabetes-induced brain and erythrocyte oxidative injuries.
Aug 11, 2015
Click here to read the entire abstract
Pubmed Data
: Brain Inj. 2015 Aug 12:1-7. Epub 2015 Aug 12. PMID:
26287758
Article Published Date
: Aug 11, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Selenium
Diseases
:
Brain: Oxidative Stress
,
Diabetes: Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Interleukin-1 beta downregulation
,
Interleukin-4 downregulation
[+]
Melatonin and selenium induced protective effects against diabetes-induced brain and erythrocyte oxidative injuries.
Aug 04, 2015
Click here to read the entire abstract
Pubmed Data
: Brain Inj. 2015 Aug 5:1-7. Epub 2015 Aug 5. PMID:
26244700
Article Published Date
: Aug 04, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Selenium
Diseases
:
Brain: Oxidative Stress
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Cytokines
[+]
Melatonin and thymoquinone protect against IR-induced injury to intestinal tissues.
Aug 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Saudi J Gastroenterol. 2015 Sep-Oct;21(5):284-9. PMID:
26458854
Article Published Date
: Aug 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Thymoquinone
Diseases
:
Intestinal Ischemia
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Melatonin and tumeric ameliorate aging-induced changes: implication of immunoglobulins, cytokines, DJ-1/NRF2 and apoptosis regulation.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Physiol Pathophysiol Pharmacol. 2018 ;10(2):70-82. Epub 2018 Apr 20. PMID:
29755640
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Turmeric
Diseases
:
Aging: Immunosenecence
Pharmacological Actions
:
Antioxidants
,
Immunomodulatory
[+]
Melatonin attentuates the spermatotoxic effects of radiofrequency radiation in mice.
May 01, 2018
Click here to read the entire abstract
Pubmed Data
: Toxicol Ind Health. 2018 May ;34(5):315-327. Epub 2018 Mar 21. PMID:
29562845
Article Published Date
: May 01, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
DNA damage
,
Infertility: Male
,
Oxidative Stress
,
Sperm Quality: Low
Pharmacological Actions
:
Antioxidants
,
Genoprotective
Anti Therapeutic Actions
:
Electromagnetic Field Harms
,
Electromagnetic Radiation
Adverse Pharmacological Actions
:
Oxidant
[+]
Melatonin attenuated the brain damage and cognitive impairment partially through MT2 melatonin receptor in mice with chronic cerebral hypoperfusion.
Sep 25, 2017
Click here to read the entire abstract
Article Publish Status
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Click here to read the complete article.
Pubmed Data
: Oncotarget. 2017 Sep 26 ;8(43):74320-74330. Epub 2017 Aug 22. PMID:
29088788
Article Published Date
: Sep 25, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Brain Damage
,
Cerebral Hypoperfusion
Pharmacological Actions
:
Neuroprotective Agents
[+]
Melatonin attenuates 1-Bromopropane-induced CNS toxicity through its ROS scavenging effect.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Medicine (Baltimore). 2016 Jan ;95(3):e2203. PMID:
26817862
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
Melatonin attenuates AFB1-induced cardiotoxicity via the NLRP3 signalling pathway.
Sep 30, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Int Med Res. 2020 Oct ;48(10):300060520952656. PMID:
33081548
Article Published Date
: Sep 30, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aflatoxicosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
Problem Substances
:
Aflatoxin
[+]
Melatonin attenuates bisphenol A-induced toxicity of the adrenal gland of Wistar rats.
Jan 05, 2019
Click here to read the entire abstract
Pubmed Data
: Environ Sci Pollut Res Int. 2019 Jan 6. Epub 2019 Jan 6. PMID:
30613877
Article Published Date
: Jan 05, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bisphenol Toxicity
Pharmacological Actions
:
Antioxidants
Problem Substances
:
Bisphenol A
[+]
Melatonin attenuates branch chain fatty acid induced apoptosis mediated neurodegeneration.
Nov 20, 2020
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol. 2020 Nov 21. Epub 2020 Nov 21. PMID:
33219756
Article Published Date
: Nov 20, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Neurodegenerative Diseases
Pharmacological Actions
:
Neuroprotective Agents
[+]
Melatonin attenuates cerebral hypoperfusion-induced hippocampal damage and memory deficits in rats by suppressing TRPM7 channels.
Mar 31, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Saudi J Biol Sci. 2022 Apr ;29(4):2958-2968. Epub 2022 Jan 18. PMID:
35531206
Article Published Date
: Mar 31, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cerebral Hypoperfusion
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Postaglandin PGE2 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin attenuates cholestatic liver injury via inhibition of the inflammatory response.
Mar 03, 2023
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2023 Mar 4. Epub 2023 Mar 4. PMID:
36869985
Article Published Date
: Mar 03, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Liver Damage
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
[+]
Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia-reperfusion injury.
Oct 04, 2020
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2020 Oct 5:e12698. Epub 2020 Oct 5. PMID:
33016468
Article Published Date
: Oct 04, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cardiomyopathy
,
Diabetic Complications
Pharmacological Actions
:
Cardioprotective
[+]
Melatonin attenuates gentamicin-induced nephrotoxicity and oxidative stress.
Sep 30, 2012
Click here to read the entire abstract
Pubmed Data
: Arch Toxicol. 2012 Oct ;86(10):1527-36. Epub 2012 Apr 12. PMID:
22526374
Article Published Date
: Sep 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Chemotherapy-Induced Toxicity: Gentamicin
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
NF-kappaB Inhibitor
,
Renoprotective
[+]
Melatonin attenuates inflammation, oxidative stress, and DNA damage in mice with nonalcoholic steatohepatitis.
Apr 12, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Inflammation. 2022 Apr 13. Epub 2022 Apr 13. PMID:
35419738
Article Published Date
: Apr 12, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
[+]
Melatonin attenuates lipopolysaccharide-induced immune dysfunction in dendritic cells.
Jun 30, 2023
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2023 Jul ;120:110282. Epub 2023 May 22. PMID:
37224647
Article Published Date
: Jun 30, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Lipopolysaccharide-Induced Toxicity
,
Lung Injury: Acute
Pharmacological Actions
:
Interleukin-12 downregulation
,
Interleukin-17 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin attenuates oxidative stress and the associated memory impairment induced by klotho deficiency.
Mar 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Neuropsychopharmacol. 2015 Apr ;18(6). Epub 2014 Dec 30. PMID:
25550330
Article Published Date
: Mar 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cognitive Decline/Dysfunction
,
Memory Disorders
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
Melatonin attenuates sepsis induced brain injury via activation SIRT1 signaling activation.
Jun 09, 2015
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2015 Jun 10. Epub 2015 Jun 10. PMID:
26094939
Article Published Date
: Jun 09, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Brain: Oxidative Stress
,
Brain Inflammation
,
Sepsis
,
Traumatic Brain Injury
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
SIRT1 Activator
,
Superoxide Dismutase Up-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Significant Treatment Outcome
[+]
Melatonin augments the effects of fluoxetine on depression.
Oct 30, 2017
Click here to read the entire abstract
Pubmed Data
: Neurosci Bull. 2017 Oct 31. Epub 2017 Oct 31. PMID:
29086908
Article Published Date
: Oct 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
,
Brain-derived neurotrophic factor modulator
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Melatonin can be considered a potential therapeutic agent to attenuate the metabolic and inflammatory disorders triggered by obesity.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Endocrinol (Lausanne). 2019 ;10:750. Epub 2019 Nov 5. PMID:
31749764
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Inflammation
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Melatonin can be used in the treatment of seizures.
Mar 21, 2016
Click here to read the entire abstract
Pubmed Data
: Behav Brain Res. 2016 Mar 22. Epub 2016 Mar 22. PMID:
27016427
Article Published Date
: Mar 21, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Epilepsy
Pharmacological Actions
:
Anticonvulsants
[+]
Melatonin can be useful as a therapeutic adjuvant for patients under long-term opioid treatment for pain relief.
Mar 20, 2016
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2016 Mar 21. Epub 2016 Mar 21. PMID:
27012766
Article Published Date
: Mar 20, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Brain Inflammation
,
Morphine Tolerance/Dependence
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Heat Shock Protein Down-Regulation
[+]
Melatonin can compensate for the adverse effects of dexamethasone on sperm parameters.
Nov 07, 2020
Click here to read the entire abstract
Pubmed Data
: Drug Chem Toxicol. 2020 Nov 8:1-10. Epub 2020 Nov 8. PMID:
33161762
Article Published Date
: Nov 07, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Fertility Agents: Male
Problem Substances
:
Dexamethasone
[+]
Melatonin can exert receptor-mediated signaling effects to attenuate inflammation and oxidative stress of the retina.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2016 ;2016:3528274. Epub 2016 Apr 6. PMID:
27143993
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Diabetic Retinopathy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
Melatonin can help protect against Wi-Fi-induced oxidative stress in the lens of rats.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Indian J Ophthalmol. 2014 Jan ;62(1):12-5. PMID:
24492496
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidants
Anti Therapeutic Actions
:
Electromagnetic Field Harms
,
Wi-Fi Radiation
[+]
Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice.
Mar 12, 2012
Click here to read the entire abstract
Pubmed Data
: Age (Dordr). 2012 Mar 13. Epub 2012 Mar 13. PMID:
22411259
Article Published Date
: Mar 12, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
,
Insulin Resistance
Pharmacological Actions
:
Insulin Sensitizers
[+]
Melatonin can inhibit glioma cell growth both in culture and in vivo.
Feb 01, 2018
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2018 Feb 2. Epub 2018 Feb 2. PMID:
29408377
Article Published Date
: Feb 01, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Gliomas
Pharmacological Actions
:
Antiproliferative
[+]
Melatonin causes regression and atrophy of the endometriotic lesions in rats.
Apr 01, 2008
Click here to read the entire abstract
Pubmed Data
: Fertil Steril. 2008 Apr;89(4):934-42. Epub 2007 Jun 19. PMID:
17582405
Article Published Date
: Apr 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Endometriosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
[+]
Melatonin combined with chondroitin sulfate ABC can promote nerve regeneration after nerve-root avulsion injury of the brachial plexus.
Jan 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Neural Regen Res. 2019 Feb ;14(2):328-338. PMID:
30531017
Article Published Date
: Jan 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Chondroitin Sulfate
,
Melatonin
Diseases
:
Neuritis: Brachial Plexus
Pharmacological Actions
:
Regenerative
Additional Keywords
:
Nerve Regeneration
[+]
Melatonin confers protective effects to rat neurons following 2.45 GHz electromagnetic radiation exposure.
Feb 01, 2012
Click here to read the entire abstract
Pubmed Data
: Physiol Behav. 2012 Feb 1 ;105(3):683-92. Epub 2011 Oct 12. PMID:
22019785
Article Published Date
: Feb 01, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Calcium Channel Blockers
Anti Therapeutic Actions
:
Electromagnetic Field Harms
,
Electromagnetic Radiation
,
Electromagnetic Radiation: 2.4 GHz
[+]
Melatonin confers radioprotective effects against mobil phone-induced oxidative stress in the rat brain.
Nov 01, 2008
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Radiat Res. 2008 Nov ;49(6):579-86. Epub 2008 Sep 29. PMID:
18827438
Article Published Date
: Nov 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Brain: Oxidative Stress
,
Oxidative Stress
Pharmacological Actions
:
Antioxidant
,
Radioprotective
Anti Therapeutic Actions
:
Electromagnetic Field Harms
,
Electromagnetic Radiation
Adverse Pharmacological Actions
:
Oxidant
[+]
Melatonin controls microbiota in colitis by goblet cell differentiation and antimicrobial peptide production.
Feb 09, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2020 Feb 10 ;10(1):2232. Epub 2020 Feb 10. PMID:
32042047
Article Published Date
: Feb 09, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Colitis
Pharmacological Actions
:
Gastrointestinal Agents
[+]
Melatonin could ameliorate exercise induced damage to liver and kidneys in rats.
Aug 25, 2015
Click here to read the entire abstract
Pubmed Data
: Endocr Metab Immune Disord Drug Targets. 2015 Aug 26. Epub 2015 Aug 26. PMID:
26310355
Article Published Date
: Aug 25, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Therapeutic Actions
:
Exercise
Pharmacological Actions
:
Hepatoprotective
,
Renoprotective
[+]
Melatonin could be a promising novel therapeutic approach against viral myocarditis.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2018 ;9:1384. Epub 2018 Dec 4. PMID:
30564119
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Coxsackievirus Infections
,
Myocarditis: Viral
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Melatonin could be beneficial reducing apoptosis and oxidative stress.
Aug 07, 2016
Click here to read the entire abstract
Pubmed Data
: Antivir Chem Chemother. 2016 Aug 8. Epub 2016 Aug 8. PMID:
27503577
Article Published Date
: Aug 07, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Encephalitis
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Malondialdehyde Down-regulation
[+]
Melatonin could be used in the reversal of schizophrenia-like symptoms and immune alterations in mice.
Sep 20, 2016
Click here to read the entire abstract
Pubmed Data
: J Psychiatr Res. 2016 Sep 21 ;84:49-58. Epub 2016 Aug 21. PMID:
27697587
Article Published Date
: Sep 20, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Schizophrenia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
Problem Substances
:
Risperidone
[+]
Melatonin could enhance the sensitivity of breast tumors to adriamycin in vivo.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Eur J Gynaecol Oncol. 2015 ;36(2):197-202. PMID:
26050360
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Breast Cancer: estrogen receptor alpha-positive
,
Quality of Life: Poor
Pharmacological Actions
:
Chemosensitizer
Additional Keywords
:
Drug: Adriamycin
,
Significant Treatment Outcome
[+]
Melatonin could protect against aluminum-induced toxicity in rats.
Jul 15, 2015
Click here to read the entire abstract
Pubmed Data
: Gen Physiol Biophys. 2015 Jul 16. Epub 2015 Jul 16. PMID:
26374992
Article Published Date
: Jul 15, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aluminum Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Hypolipidemic
Problem Substances
:
Aluminum
[+]
Melatonin could protect against liver injury caused by alcohol gastric perfusion.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Alcohol Alcohol. 2016 Jan ;51(1):11-9. Epub 2015 Nov 11. PMID:
26564773
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Alcohol Toxicity
,
Alcoholic Liver Disease
Pharmacological Actions
:
Adenosine Monophosphate (AMP)-activated Protein Kinase (AMPK
,
Hepatoprotective
[+]
Melatonin could significantly reduce endoplasmic reticulum stress in leptin-deficient obese animals.
Apr 18, 2016
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2016 Apr 19. Epub 2016 Apr 19. PMID:
27090356
Article Published Date
: Apr 18, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Obesity
[+]
Melatonin deficiency could be a key mechanism explaining the co-morbidity effect in the association between obesity and periodontitis.
Jun 13, 2018
Click here to read the entire abstract
Pubmed Data
: J Periodontal Res. 2018 Jun 14. Epub 2018 Jun 14. PMID:
29900537
Article Published Date
: Jun 13, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Hormone Imbalances: Low Melatonin
,
Obesity
,
Periodontitis
[+]
Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels.
Jun 12, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Mol Life Sci. 2022 Jun 13 ;79(7):361. Epub 2022 Jun 13. PMID:
35697820
Article Published Date
: Jun 12, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Coronavirus Infection
Pharmacological Actions
:
Antiviral Agents
,
Neuroprotective Agents
[+]
Melatonin enhances mitochondrial biogenesis and protects against rotenone-induced mitochondrial deficiency in early porcine embryos.
Nov 26, 2019
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2019 Nov 27:e12627. Epub 2019 Nov 27. PMID:
31773776
Article Published Date
: Nov 26, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Mitochondrial Dysfunction
Pharmacological Actions
:
Cytoprotective
Problem Substances
:
Rotenone
[+]
Melatonin exerts neuroprotective properties to counteract the negative effects of electromagnetic fields.
Jun 01, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cell Mol Med. 2014 Jun ;18(6):1060-70. Epub 2014 Feb 18. PMID:
24548607
Article Published Date
: Jun 01, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Pharmacological Actions
:
Antioxidants
,
Calcium Channel Blockers
Anti Therapeutic Actions
:
Electromagnetic Field Harms
,
Electromagnetic Radiation
[+]
Melatonin exerts potent antioxidant effects in the testes of rats exposed to microwaves by decreasing the intensity of oxidative stress; it also reduces DNA fragmentation.
Apr 30, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Adv Clin Exp Med. 2015 May-Jun;24(3):429-36. PMID:
26467130
Article Published Date
: Apr 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
DNA damage
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Genoprotective
Anti Therapeutic Actions
:
Microwave Radiation
[+]
Melatonin exhibits potent antioxidant properties that may create favourable conditions for the recovery of liver function following IRI.
Apr 30, 2016
Click here to read the entire abstract
Pubmed Data
: Exp Ther Med. 2016 May ;11(5):1955-1960. Epub 2016 Mar 15. PMID:
27168834
Article Published Date
: Apr 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Lipid Peroxidation
,
Liver Injury: Ischemia/reperfusion
Pharmacological Actions
:
Antioxidants
[+]
Melatonin exposure improves liver tissue damage caused by arsenic exposure.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Ulus Cerrahi Derg. 2016 ;32(4):233-237. Epub 2016 Oct 27. PMID:
28149117
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Arsenic Poisoning
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Arsenic Poisoning
,
Hepatoprotective
,
melatonin
Problem Substances
:
Arsenic
[+]
Melatonin had a significant biochemical antioxidant effect and histological renoprotective effect.
Sep 30, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Taibah Univ Med Sci. 2020 Oct ;15(5):351-357. Epub 2020 Jul 17. PMID:
33132806
Article Published Date
: Sep 30, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Renoprotective
[+]
Melatonin had protective roles in hypertension induced renal injury.
Nov 01, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2015 Nov 2. Epub 2015 Nov 2. PMID:
26531807
Article Published Date
: Nov 01, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Hypertension
,
Kidney Damage
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Renoprotective
[+]
Melatonin had significant analgesic effects in the treatment of post herpetic neuralgia.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Clin Exp Med. 2015 ;8(4):5004-9. Epub 2015 Apr 15. PMID:
26131073
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Neuralgia: Post Herpetic
Pharmacological Actions
:
Analgesics
[+]
Melatonin has a favorable effect on the level of oxidative damage and neurodegeneration in age-accelerated mice.
Oct 01, 2008
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2008 Oct;45(3):302-11. Epub 2008 Apr 13. PMID:
18410310
Article Published Date
: Oct 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
,
Aging: Brain
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
,
Receptor-Related Orphan Receptor (ROR)-Alpha1 Inhibitor
[+]
Melatonin has a protective action against BPA-induced deterioration of oocyte quality in mice.
Feb 07, 2017
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2017 Feb 8. Epub 2017 Feb 8. PMID:
28178360
Article Published Date
: Feb 07, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Bisphenol Toxicity
,
Infertility
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
Problem Substances
:
Bisphenol A
[+]
Melatonin has a protective effect against formaldehyde-induced oxidative damage and apoptosis in rat testes.
Jun 30, 2008
Click here to read the entire abstract
Pubmed Data
: Syst Biol Reprod Med. 2008 Jul-Aug;54(4-5):169-76. PMID:
18942024
Article Published Date
: Jun 30, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Oxidative Stress
,
Testicular Injury: Formaldehyde-Induced
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Malondialdehyde Down-regulation
,
Superoxide Dismutase Up-regulation
[+]
Melatonin has a significant effect on the protection of the heart against isoproterenol induced myocardial infarction through maintaining endogenous antioxidant enzyme activities.
Oct 09, 2010
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2010 Oct 10 ;644(1-3):160-8. Epub 2010 Jul 13. PMID:
20624385
Article Published Date
: Oct 09, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Myocardial Infarction
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
Additional Keywords
:
Drug: Isoproterenol
[+]
Melatonin has ameliorative properties in an animal mode of experimental colitis.
Nov 01, 2006
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2006 Nov;41(4):363-73. PMID:
17014694
Article Published Date
: Nov 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Colitis
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin has an ameliorative effect against gamma-irradiation-induced oxidative stress and tissue injury.
Feb 01, 2007
Click here to read the entire abstract
Pubmed Data
: Ecotoxicol Environ Saf. 2007 Feb;66(2):278-86. Epub 2006 Jun 21. PMID:
16793135
Article Published Date
: Feb 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Radiation Induced Illness
,
Radiation-Induced Illness: Cesium-137 Exposure
Pharmacological Actions
:
Antioxidants
,
Radioprotective
[+]
Melatonin has an inhibitory effect on DMBA-induced cervical and vaginal cancer in mice.
Aug 11, 2000
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2000 Aug 11;156(2):199-205. PMID:
10880770
Article Published Date
: Aug 11, 2000
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Cervical Cancer
,
Vaginal Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antimutagenic Agents
[+]
Melatonin has an inhibitory effect on the growth of pituitary prolactin-secreting tumor in rats.
Apr 01, 2006
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2006 Apr;40(3):230-5. PMID:
16499559
Article Published Date
: Apr 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Pituitary Tumours
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
[+]
Melatonin has antioxidant, anti-inflammatory and hepatoprotective effects in case of IR.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Ann Ital Chir. 2016 ;87:271-9. PMID:
27346180
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Liver Injury: Ischemia/reperfusion
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
[+]
Melatonin has been demonstrated to be a highly efficient anti-aging factor which may reduce age-related skin changes.
Oct 01, 2005
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2005 Oct;39(3):231-7. PMID:
16150102
Article Published Date
: Oct 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
,
Aging Skin
[+]
Melatonin has beneficial effects on cardiological alterations in a mouse model of accelerated aging.
Oct 01, 2010
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2010 Oct;49(3):312-20. Epub 2010 Aug 3. PMID:
20738757
Article Published Date
: Oct 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cardioprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin has beneficial effects on impaired intestinal epithelial permeability in type 2 diabetes.
Mar 28, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2016 Mar 29. Epub 2016 Mar 29. PMID:
27023908
Article Published Date
: Mar 28, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Hypoglycemic Agents
,
Hypolipidemic
[+]
Melatonin has cardioprotective effects in a rat model of cardiorenal syndrome.
Jul 27, 2016
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2016 Jul 28. Epub 2016 Jul 28. PMID:
27465663
Article Published Date
: Jul 27, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Heart Disease
,
Kidney Diseases
,
Multi-Organ Failure
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin has neuroprotective properties in an animal model of accelerated aging.
May 16, 2011
Click here to read the entire abstract
Pubmed Data
: Rev Neurol. 2011 May 16;52(10):618-622. PMID:
21488009
Article Published Date
: May 16, 2011
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
,
Aging: Brain
Pharmacological Actions
:
Neuroprotective Agents
[+]
Melatonin has neuroprotective properties superior to methyprednisone in experimental spinal cord injury.
Oct 01, 2005
Click here to read the entire abstract
Pubmed Data
: Surg Neurol. 2005 Oct;64(4):355-61. PMID:
16231427
Article Published Date
: Oct 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Lipid Peroxidation
,
Spinal Cord Injuries
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
Additional Keywords
:
Cortisone Alternatives
,
Superiority of Natural Substances versus Drugs
[+]
Melatonin has shown to be effective in controlling metastatic breast cancer in vitro and in vivo.
Aug 20, 2015
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2015 Aug 21. Epub 2015 Aug 21. PMID:
26292662
Article Published Date
: Aug 20, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Breast Cancer
,
Breast Cancer: Lung Metastasis
,
Breast Cancer: Metastatic
Pharmacological Actions
:
Anti-metastatic
[+]
Melatonin improved the depressive behaviour of stressed mice.
Jul 10, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Neurosignals. 2016 Jul 11 ;24(1):48-58. Epub 2016 Jul 11. PMID:
27398923
Article Published Date
: Jul 10, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
,
Neurogenesis
[+]
Melatonin improves functional recovery as effectively as methylpredisolone in experimental spinal cord injury.
Dec 01, 2004
Click here to read the entire abstract
Pubmed Data
: Eur Spine J. 2004 Dec;13(8):724-32. Epub 2004 Jul 1. PMID:
15232723
Article Published Date
: Dec 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Spinal Cord Injuries
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Cortisone Alternatives
,
Natural Substances Versus Drugs
[+]
Melatonin improves inflammation processes in the liver of age-accelerated prone male mice.
Dec 01, 2010
Click here to read the entire abstract
Pubmed Data
: Exp Gerontol. 2010 Dec;45(12):950-6. Epub 2010 Sep 9. PMID:
20817086
Article Published Date
: Dec 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
,
Interleukin-10 downregulation
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin improves metabolic syndrome induced by high fructose intake in rats.
Apr 30, 2012
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2012 May ;52(4):403-13. Epub 2012 Jan 6. PMID:
22220562
Article Published Date
: Apr 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
High Fructose Diet
,
Insulin Resistance
,
Metabolic Syndrome X
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Melatonin improves pro-survival signals and reduces pro-death signals in age-related impairments of neural processes.
Nov 01, 2008
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2008 Nov;45(4):497-505. Epub 2008 Aug 13. PMID:
18705649
Article Published Date
: Nov 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging
,
Aging: Brain
,
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Melatonin increases brown adipose tissue mass and function.
Feb 05, 2018
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2018 Feb 6. Epub 2018 Feb 6. PMID:
29405372
Article Published Date
: Feb 05, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease
May 31, 2003
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Neurochem. 2003 Jun ;85(5):1101-8. PMID:
12753069
Article Published Date
: May 31, 2003
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Melatonin induces cognitive enhancement and brain resilience against neurodegenerative processes.
Jun 14, 2018
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2018 Jun 15:e12515. Epub 2018 Jun 15. PMID:
29907977
Article Published Date
: Jun 14, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Neurodegenerative Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
Melatonin inhibits benzene-induced lipid peroxidation in rat liver.
Mar 01, 2010
Click here to read the entire abstract
Pubmed Data
: Arh Hig Rada Toksikol. 2010 Mar;61(1):11-8. PMID:
20338863
Article Published Date
: Mar 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Benzene Toxicity
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
[+]
Melatonin inhibits cytosolic mitochondrial-DNA induced neuroinflammatory signaling in accelerated aging and neurodegeneration.
Mar 16, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Clin Invest. 2020 Mar 17. Epub 2020 Mar 17. PMID:
32182222
Article Published Date
: Mar 16, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Aging: Brain
,
Huntington Disease
,
Neurodegenerative Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
Melatonin inhibits inflammasome-associated activation of endothelium and macrophages attenuating pulmonary arterial hypertension.
Nov 26, 2019
Click here to read the entire abstract
Pubmed Data
: Cardiovasc Res. 2019 Nov 27. Epub 2019 Nov 27. PMID:
31774487
Article Published Date
: Nov 26, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Hypertension: Pulmonary
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Melatonin inhibits oxidative stress and programmed cell death in fetal brains of hyperhomocysteinemic rat dams.
Oct 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2007 Oct;43(3):225-31. PMID:
17803518
Article Published Date
: Oct 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
High Homocysteine
,
Lipid Peroxidation
,
Oxidative Stress
,
Prenatal Nutrition: Prevention of Problems
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Neuroprotective Agents
,
Tumor Suppressor Protein p53 Upregulation
[+]
Melatonin inhibits VEGF-induced endothelial progenitor cell angiogenesis in neovascular age-related macular degeneration.
Mar 02, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cells. 2023 Mar 3 ;12(5). Epub 2023 Mar 3. PMID:
36899935
Article Published Date
: Mar 02, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Macular Degeneration
Pharmacological Actions
:
Anti-Angiogenic
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Melatonin intervention reduced autophagy by ameliorating inflammation and oxidative stress in a mouse model of colitis-associated colon carcinogenesis.
Jan 15, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Carcinog. 2015 Jan 16. Epub 2015 Jan 16. PMID:
25598500
Article Published Date
: Jan 15, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Colon Cancer: Prevention
,
Oxidative Stress
,
Ul