Melatonin

Name	AC	CK
Oxidative Stress	103	272
Sleep Disorders	18	136
Breast Cancer	47	119
Delirium	7	102
Inflammation	34	101
Alzheimer's Disease	32	80
Parkinson's Disease	14	63
Insomnia	7	62
Hormone Imbalances: Low Melatonin	10	59
Obesity	19	52
C-Reactive Protein	4	50
Circadian Dysregulation	10	50
Cancers: All	12	49
Testicular Injury: Chemical/Metal Induced	16	49
Epilepsy	8	48
Neurodegenerative Diseases	19	45
Depression	14	43
Diabetes Mellitus: Type 2	13	42
Lipid Peroxidation	13	42
Multiple Sclerosis	10	40
Coronavirus Infection	10	39
Bisphenol Toxicity	22	37
Lipopolysaccharide-Induced Toxicity	14	35
Periodontitis	8	35
Headache	7	34
Chronic Pain	5	33
Muscle Damage: Exercise-Induced	5	32
Sepsis	11	32
Chemotherapy and Radiation Toxicity	9	31
Aging	17	30
Tinnitus	3	30
Stroke: Ischemic	6	28
Brain Injury: Traumatic	6	27
Prostate Cancer	6	25
Cognitive Decline/Dysfunction	8	24
Chemically-Induced Liver Damage	7	23
Jet Lag	4	23
Liver Cancer	13	23
Heart Failure	3	22
Metabolic Syndrome X	2	22
Nocturia	3	22
Osteoporosis	8	22
Gastroesophageal Reflux	3	21
Headache: Migraine	3	21
Insulin Resistance	7	21
Burns	1	20
Cancer: Fatigue	2	20
Cardiac Surgery	2	20
Delayed Sleep Phase Disorder	1	20
Depressive Disorder	2	20
Multiple Sclerosis: Relapsing-Remitting	2	20
Overweight	1	20
Postoperative Recovery	2	20
Purpura: Thrombocytopenic	2	20
Thrombocytopenia	2	20
Diabetic Nephropathy	6	19
Aging: Brain	9	18
Aluminum Toxicity	9	17
Hypertension	5	17
Liver Damage	5	17
Ovarian Cancer	7	17
DNA damage	8	16
Infertility: Male	8	16
Anxiety	9	15
Polycystic Ovary Syndrome	4	15
Brain: Oxidative Stress	8	14
Colorectal Cancer	5	14
Fibromyalgia	4	14
Liver Fibrosis	5	14
Squamous cell carcinoma	4	14
Aging Skin	3	13
Benzo[a]pyrene-induced Toxicity	3	13
Fluoride Toxicity	7	13
Irritable Bowel Syndrome	4	13
Pancreatitis	3	13
Spinal Cord Injuries	7	13
Autism	2	12
Brain Inflammation	7	12
Breast Cancer: Metastatic	2	12
Chemotherapy-Induced Toxicity: Cyclophosphamide	2	12
Mitochondrial Dysfunction	7	12
Myocardial Ischemia	6	12
Oral Mucositis	2	12
Periodontal Diseases	3	12
Scoliosis	2	12
Anxiety Disorders	2	11
Bipolar Disorder	2	11
Chemotherapy-Induced Toxicity: Cisplatin	6	11
Migraines	2	11
Myocardial Infarction	6	11
Osteoarthritis: Knee	2	11
Pneumonia	2	11
Prostatic Hyperplasia: Benign	2	11
Radiation Induced Illness	6	11
Radiation-Induced Illness: Radioiodine (Iodine-131)	2	11
Retinal Diseases	2	11
Septic Shock	2	11
Skin Diseases	2	11
Tongue Cancer	2	11
Abdominal Obesity (Midsection Fat)	1	10
Aneurysmal subarachnoid hemorrhage (SAH)	1	10
Asperger Syndrome	1	10
Athletic Performance	1	10
Bone Fractures	1	10
Cataract	1	10
Cesarean Section	1	10
Chronic Fatigue Syndrome	1	10
Chronic Obstructive Pulmonary Disease	1	10
Cirrhosis	1	10
Coronary Artery Disease	1	10
Coronary Bypass Surgery	1	10
Cortisol: High	1	10
Depression: Breast Cancer Related	1	10
Dyspepsia	1	10
Erythema	1	10
Fatigue	1	10
Female	1	10
Gastric Cancer	8	10
Genital Herpes	1	10
Glyphosate Toxicity	5	10
Graves Disease	1	10
Helicobacter Pylori Infection	1	10
Hemodialysis	1	10
Human Growth Hormone: Enhancement	1	10
Melasma	1	10
Osteoarthritis: Hip	1	10
Osteopenia	1	10
Osteosarcoma	6	10
Pain: Post-operative	1	10
Premature Birth	1	10
Retinal Sensitivity	1	10
Sclerosis: Systemic	1	10
Skin Diseases: Photo-Aging	1	10
Sleep Apnea: Obstructive	1	10
Thrombosis	1	10
Weight Gain: Drug-Induced	1	10
Endothelial Dysfunction	6	9
Infertility	3	9
Cadmium Poisoning	5	8
Cancer Metastasis	4	8
Cerebral Ischemia	5	8
Diabetes Mellitus: Type 1	5	8
Endometriosis	6	8
High Fat Diet	4	8
Kidney Damage: Chemically-Induced	4	8
Liver Injury: Ischemia/reperfusion	5	8
Lung Injury: Acute	5	8
Mobile Phone-Induced Oxidative Stress	4	8
Osteoarthritis	5	8
Radiation	4	8
Cardiovascular Diseases	6	7
Chemotherapy-Induced Toxicity: Doxorubicin	4	7
Colon Cancer	6	7
Hypoxia	3	7
Kidney Damage	4	7
Liver Disease	4	7
Pesticide Toxicity	4	7
Sperm Quality: Low	2	7
Alcohol Toxicity	3	6
Cardiomyopathy	4	6
Cerebral Hypoperfusion	3	6
Cervical Cancer	5	6
Colitis	3	6
Diabetes: Cognitive Dysfunction	3	6
Diabetic Complications	3	6
Dysbiosis	3	6
High Fructose Diet	3	6
Ischemia	4	6
Kidney Damage: Drug-Induced	3	6
Lung Cancer	2	6
Memory Disorders	3	6
Microplastic Toxicity	3	6
Stress	3	6
Stroke: Attenuation/Recovery	5	6
Air Pollution Linked Toxicity	3	5
Amyotrophic Lateral Sclerosis	5	5
Atherosclerosis	3	5
Breast Cancer: Triple Negative	4	5
Glioblastoma	5	5
Huntington Disease	4	5
Neuroblastoma	1	5
Osteoporosis: Inflammation Induced	1	5
Pancreatic Cancer	4	5
Traumatic Brain Injury	3	5
Ultraviolet Radiation Induced Damage	4	5
Wound Healing	3	5
Acrylamide-induced toxicity	2	4
Aging: Immunosenecence	3	4
Alcoholic Liver Disease	2	4
Chemotherapy-Induced Kidney Damage	2	4
Chemotherapy-Induced Toxicity	3	4
Chemotherapy-Induced Toxicity: Gentamicin	2	4
Dementia	3	4
Diabetes: Oxidative Stress	2	4
Diabetic Retinopathy	2	4
Drug-Induced Toxicity: Methotrexate	2	4
Electromagnetic Radiation Mitigation	2	4
Encephalitis	2	4
Hypertension: Pulmonary	2	4
Kidney Diseases	2	4
Leukemia	3	4
Liver Cirrhosis	2	4
Lung Damage	2	4
Macular Degeneration	4	4
Memory Disorders: Sleep Deprivation Induced	2	4
Metabolic Diseases	2	4
Neonatal Stroke	2	4
Nicotine/Tobacco Toxicity	3	4
Pineal Gland Calcification	3	4
Pregnancy Complications	2	4
Psychiatric Disorders	3	4
Schizophrenia	3	4
Subarachnoid hemorrhage	3	4
Arsenic Poisoning	2	3
Brain Damage	2	3
Brain Ischemia	2	3
Breast Cancer: Estrogen	3	3
Breast Cancer: estrogen receptor alpha-positive	2	3
Endotoxemia	2	3
Gastric Ulcer	2	3
Head and Neck Cancer	2	3
Kidney Stones	1	3
Nephrolithiasis	1	3
Oral Cancer	3	3
Pituitary Tumours	2	3
Systemic Lupus Erythematosus	3	3
Ulcerative Colitis	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Acute Respiratory Distress Syndrome	2	2
Aflatoxicosis	1	2
Aging: Heart	1	2
Amnesia	1	2
Amyotrophic lateral sclerosis (ALS)	2	2
Asthma	1	2
Atopic Dermatitis	1	2
Autism Spectrum Disorders	2	2
Autoimmune Diseases	2	2
Benzene Toxicity	1	2
Bile Duct Injury	1	2
Blood Diseases	1	2
Bone Diseases	1	2
Breast Cancer: Lung Metastasis	1	2
Cancer: Prostate	1	2
Cardiac Hypertrophy	1	2
Cardiovascular Disease	1	2
Cataract: Radiation-Induced	1	2
Cell Phone Induced Disease	1	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Chemotherapy-Induced Toxicity: Epirubicin	1	2
Chemotherapy-Induced Toxicity: Oxaliplatin	1	2
Cholestasis	1	2
Chronic Kidney Disease (CKD)	2	2
Cocaine Addiction	1	2
Cocaine Withdrawal	1	2
Colon Cancer: Prevention	1	2
Coronavirus Disease (Covid-19)	2	2
Cough	1	2
Coxsackievirus Infections	1	2
Degenerative Disk Disease	1	2
Demyelinating Diseases	1	2
Depression	1	2
Depression: Stress Related	1	2
Diabetes	1	2
Drug Toxicity: Methotrexate	1	2
Drug-Induced Toxicity: Bisphosphonates	1	2
Drug-Induced Toxicity: Indomethacin	1	2
Edema	1	2
Endometrial Cancer	1	2
Estrogen Deficiency	1	2
Fibrosis	1	2
Fructose-Induced Toxicity	1	2
Glaucoma	3	2
Gliomas	1	2
Glutathione Deficiency	1	2
HIV Drug-Induced Toxicity	1	2
Headache: Cluster	2	2
Heart Disease	1	2
Hepatic Steatosis	1	2
Herbicide Toxicity	1	2
High Homocysteine	1	2
High Sugar Diet	1	2
Hydrogen Peroxide Induced Toxicity	2	2
Hyperalgesia	1	2
Hyperbilirubinemia: Hereditary	1	2
Hypercholesterolemia	1	2
Hyperglycemia	1	2
Hyperlipidemia	1	2
Hyperthyroidism	1	2
Hypothyroidism	1	2
Hypoxia: Brain	1	2
Immune Disorders: Low Immune Function	1	2
Inflammation: Brain	1	2
Influenza	1	2
Intestinal Ischemia	1	2
Kidney Cancer	2	2
Kidney Failure	1	2
Kidney Fibrosis	2	2
Learning disorders	1	2
Leiomyosarcoma	1	2
Liver Damage: Drug-Induced	1	2
Low Immune Function: Natural Killer Cells	1	2
Lymphoma: B-Cell	2	2
Malaria	1	2
Melanoma	2	2
Morphine Tolerance/Dependence	1	2
Multi-Organ Failure	1	2
Myocarditis: Viral	1	2
Necrotising enterocolitis	1	2
Neural Tube Defects	1	2
Neuralgia: Post Herpetic	1	2
Neuritis: Brachial Plexus	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Obstructive Nephropathy	1	2
Optic Neuritis	1	2
Ovarian Failure	1	2
Ovariectomy Associated Adverse Changes	1	2
Perimenopausal Syndrome	1	2
Plasmodium Infections	1	2
Prediabetes	1	2
Prenatal Chemical Exposures	1	2
Prenatal Nutrition: Prevention of Problems	1	2
Psoriasis	1	2
Quality of Life: Poor	1	2
Radiation-Induced Illness: Cesium-137 Exposure	1	2
Rheumatoid Arthritis	2	2
Sciatic Nerve Crush Injury	1	2
Sciatica	1	2
Sleep Apnea: Central	1	2
Snake Bite: Venom Toxicity	1	2
Substance Abuse	1	2
Surgery: Anesthesiology	1	2
Testicular Injury: Formaldehyde-Induced	1	2
Testicular Injury: Nicotine-Induced	1	2
Tumors	2	2
Vaginal Cancer	1	2
Acute Myeloid Leukemia	1	1
Acute T cell Leukemias	1	1
Acute lymphoblastic leukemia (ALL)	1	1
Amphetamine Addiction/Withdrawal	1	1
Animal Cancers	1	1
Asphyxia	1	1
Bacterial Infections	1	1
Brain Edema	1	1
Cancers: Drug Resistant	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Chemotherapy	1	1
Chemotherapy-Induced Toxicity: Arsenic Trioxide	1	1
Chronic Disease	1	1
Crohn's Disease	1	1
Diabetes: Cardiovascular Illness	1	1
Dysmenorrhea	1	1
Ebola Virus Infections	1	1
Encephalomyelitis	1	1
Encephalopathy	1	1
Encephalopathy: Hypoxic	1	1
Endocrine Diseases	1	1
Endothelial Damage	1	1
Esophageal Cancer	1	1
Estrogen Dominance	1	1
Eye Damage	1	1
Fractures: Bone	1	1
Fragile X Syndrome	1	1
Gallbladder Inflammation	1	1
Gallstones	1	1
Gastritis	1	1
Glioma	1	1
Heavy Metal Toxicity	1	1
Herpes Simplex Virus Type 1	1	1
Inflammatory Bowel Diseases	1	1
Leiomyoma	1	1
Liver Damage: Aflatoxin-Induced	1	1
Lung Injury: Smoke-Induced	1	1
Lymphoma	1	1
Mastitis	1	1
Migraine Disorders	1	1
Mitochondrial Diseases	1	1
Mood Disorders	1	1
Myasthenia Gravis	1	1
Napthalene-Induced Toxicity	1	1
Nasopharyngeal Cancer	1	1
Non-Small-Cell Lung Carcinoma	1	1
Organ Transplantation	1	1
Organ Transplantation: Liver	1	1
Pancreatic Diseases	1	1
Parasitic Diseases	1	1
Photooxidative Stress	1	1
Pineal Gland Diseases	1	1
Post-Traumatic Stress Disorders (PTSD)	1	1
Proliferative Vitreoretinopathy (PVR)	1	1
Pulmonary Fibrosis	1	1
Renal Cancer	1	1
Retinopathy of Prematurity	1	1
Sarcoma: Ewing's	1	1
Sjogren's Syndrome	1	1
Stroke	1	1
Stroke: Hemorrhagic	1	1
Thyroid Cancer	1	1
Vaccine-induced Toxicity	1	1
Wound Healing: Delayed	1	1
Abdominal Adhesions	1	0
Sarcoidosis	1	0

Name	AC	CK
Antioxidants	245	599
Anti-Inflammatory Agents	148	365
Neuroprotective Agents	134	337
Hepatoprotective	42	93
Antiproliferative	58	89
Anti-Apoptotic	52	87
Cardioprotective	35	87
Tumor Necrosis Factor (TNF) Alpha Inhibitor	30	86
Apoptotic	58	82
Radioprotective	23	78
Antidepressive Agents	14	70
Renoprotective	32	69
Analgesics	11	66
Prophylactic Agents	9	64
Interleukin-6 Downregulation	14	58
Chemotherapeutic	17	54
Chemoprotective Agents	18	51
Gastrointestinal Agents	16	48
NF-kappaB Inhibitor	27	43
Interleukin-1 beta downregulation	20	37
Anti-metastatic	28	35
Anticonvulsants	4	35
Malondialdehyde Down-regulation	13	33
Immunomodulatory	23	31
Hypoglycemic Agents	7	30
Nrf2 activation	18	29
Chemosensitizer	23	28
Brain-derived neurotrophic factor modulator	4	26
Regenerative	8	25
Superoxide Dismutase Up-regulation	13	25
Cyclooxygenase 2 Inhibitors	12	24
Cytoprotective	13	23
Insulin Sensitizers	3	22
Secretagogue	3	22
Antinoceceptive	1	20
Hypnotics and Sedatives	2	20
Osteogenic	4	19
Anti-Fibrotic	8	18
Antihypertensive Agents	6	18
Antiviral Agents	7	18
Gastroprotective	9	18
Hypolipidemic	5	18
Tumor Suppressor Protein p53 Upregulation	15	18
Angiogenesis Inhibitors	11	17
Matrix metalloproteinase-9 (MMP-9) inhibitor	11	14
Osteoprotective	8	13
Heme oxygenase-1 up-regulation	9	12
Vascular Endothelial Growth Factor Inhibitors	6	12
Chemopreventive	7	11
Genoprotective	5	11
Proton Pump Inhibitor	2	11
Adiponectin upregulation	1	10
Anti-Anxiety Agents	6	10
Antineoplastic Agents	8	10
Anxiolytic	1	10
Bcl-2 protein down-regulation	7	10
Cell cycle arrest	10	10
Insulin-Like Growth Factor Inhibition/Downregulation	1	10
Matrix metalloproteinase-2 (MMP-2) inhibitor	5	10
MicroRNA modulator	8	10
Sedative effects	1	10
Vasodilator Agents	1	10
Anticarcinogenic Agents	5	9
Antioxidant	3	9
Autophagy Inhibitors	5	8
Interleukin-17 downregulation	4	7
Cyclin D1 Down-Regulation	3	6
Pancreato Protective Agents	3	6
Autophagy Up-regulation	4	5
Fertility Agents: Male	3	5
Nitric Oxide Inhibitor	1	5
Prostaglandin PGE2 downregulation	1	5
Anti-Angiogenic	3	4
Anticholesteremic Agents	2	4
Calcium Channel Blockers	2	4
Catalase Up-Regulation	2	4
Glutathione Upregulation	2	4
Interleukin-12 downregulation	2	4
Neurogenesis	3	4
Photoprotective	3	4
Radiosensitizer	4	4
Antimutagenic Agents	2	3
Aromatase Inhibitors	3	3
Caspase-3 Activation	2	3
Chondroprotective	2	3
DNA Repair Up-regulation	2	3
Detoxifier	2	3
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	3	3
Immunostimulatory	3	3
Interleukin-8 downregulation	3	3
Transforming growth factor beta (TGF-β) inhibitor	2	3
Wnt/β-catenin signaling pathway modulation	2	3
Acetylcholinesterase Inhibitor	1	2
Adenosine Monophosphate (AMP)-activated Protein Kinase (AMPK	1	2
Anti-Proliferative	1	2
Anti-Ulcer Agents	1	2
Anti-atherogenic	1	2
BRCA-1 Downregulation	2	2
Fertility Agents	1	2
Heat Shock Protein Down-Regulation	1	2
Interleukin-10 downregulation	1	2
Interleukin-4 downregulation	1	2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	2
Matrix metalloproteinase-8 (MMP-8) inhibitor	1	2
Neuroplasticity enhancement	1	2
Neurorestorative	1	2
Postaglandin PGE2 downregulation	1	2
Receptor-Related Orphan Receptor (ROR)-Alpha1 Inhibitor	1	2
SIRT1 Activator	1	2
12-lipoxygenase (12-LOX) Inhibitor	1	1
Apaf-1/caspase-dependent apoptotic pathway activator	1	1
Bax/Bcl2 ratio: Increase	1	1
Caspase-9 Activation	1	1
Cell Differentiation Inducer	1	1
Cyclooxygenase Inhibitors	1	1
Drug synergy	1	1
Enzyme Inhibitors	1	1
Immunomodulatory: Th17 downregulation	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
P21 Activation	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
PI3K/Akt/signaling suppression	1	1
Selective estrogen enzyme modulator (SEEM)	1	1
Telomerase Inhibitor	1	1
Telomerase Upregulation	1	1
Telomere Protective	1	1
Tumor Necrosis Factor (TNF) Alpha Enhancer	1	1
Vascular Endothelial Growth Factor A Inhibitor	1	1
p300/NF-κB down-regulation	1	1

Pharmacological Actions : Antioxidants, Chemoprotective Agents, Radioprotective

[+]

The therapeutic effect of exogenous melatonin on depressive symptoms.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sleep. 2010 Dec;33(12):1605-14. PMID: 21120122

Article Published Date : Dec 01, 2010

Study Type : Meta Analysis

Additional Links

Substances : Melatonin

Diseases : Delayed Sleep Phase Disorder, Sleep Disorders

[+]

Melatonin may decrease the incidence of delirium for special ICU patients.Mar 21, 2024

Click here to read the entire abstract

Pubmed Data : Altern Ther Health Med. 2024 Mar 22. Epub 2024 Mar 22. PMID: 38518134

[+]

Administration of melatonin as an adjuvant therapy in the treatment of neonatal sepsis is associated with improvement of clinical and laboratory outcomes.Oct 08, 2015

Click here to read the entire abstract

Pubmed Data : J Neonatal Perinatal Med. 2015 Oct 9. Epub 2015 Oct 9. PMID: 26485549

Article Published Date : Oct 08, 2015

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Sepsis

[+]

Administration of melatonin, alone or in a combination with fluoxetine was effective in the treatment of patients with fibromyalgia.Mar 31, 2011

Click here to read the entire abstract

Pubmed Data : J Pineal Res. 2011 Apr ;50(3):267-71. Epub 2010 Dec 16. PMID: 21158908

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Arch Gen Psychiatry. 2011 Jan ;68(1):61-70. PMID: 21199966

Article Published Date : Dec 31, 2010

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Depressive Disorder

Therapeutic Actions : Light Therapy

Pharmacological Actions : Antidepressive Agents

[+]

Circadian melatonin disruption can be used as an indicator of delirium.Sep 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sleep Sci. 2016 Oct-Dec;9(4):285-288. Epub 2016 Aug 10. PMID: 28154742

Article Published Date : Sep 30, 2016

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Circadian Dysregulation, Delirium

[+]

[+]

Low-dose melatonin for sleep disturbances in early-stage cirrhosis.Jul 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : JGH Open. 2020 Aug ;4(4):749-756. Epub 2020 May 18. PMID: 32782966

Article Published Date : Jul 31, 2020

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Cirrhosis, Sleep Disorders

[+]

Lower serum levels of melatonin in ovarian cancer patients which may contribute to the pathogenesis of ovarian cancer.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacoepidemiol Drug Saf. 2009 Dec;18(12):1143-9. PMID: 12804129

Article Published Date : Dec 01, 2009

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Asperger Syndrome

[+]

Melatonin as preemptive analgesic for intraoperative pain.Dec 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Bioinformation. 2023 ;19(1):5-9. Epub 2023 Jan 31. PMID: 37720297

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Exp Dent. 2015 Dec ;7(5):e628-e633. Epub 2015 Dec 1. PMID: 26644840

Article Published Date : Nov 30, 2015

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : C-Reactive Protein, Inflammation, Periodontal Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Melatonin could be effective and safe for decreasing daytime seizure frequency in patients with intractable epilepsy.Feb 28, 2012

Click here to read the entire abstract

Pubmed Data : J Child Neurol. 2012 Feb 28. Epub 2012 Feb 28. PMID: 22378657

Article Published Date : Feb 28, 2012

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Epilepsy

[+]

Melatonin could be used in migraine prophylaxis treatments. Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : Iran J Child Neurol. 2018 ;12(1):47-54. PMID: 29379562

Article Published Date : Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Breast Cancer Res Treat. 2014 Jun ;145(3):683-95. Epub 2014 Apr 23. PMID: 24756186

Article Published Date : May 31, 2014

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Depression: Breast Cancer Related

Therapeutic Actions : Placebo Effect

Pharmacological Actions : Antidepressive Agents

[+]

Melatonin supplementation enhances pulmonary rehabilitation outcomes in COPD.Nov 30, 2023

Click here to read the entire abstract

Pubmed Data : Respir Med. 2023 Dec ;220:107441. Epub 2023 Nov 7. PMID: 37944829

Article Published Date : Nov 30, 2023

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Chronic Obstructive Pulmonary Disease

[+]

Melatonin supplementation improves N-terminal pro-B-type natriuretic peptide levels and quality of life in patients with heart failure.Mar 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Womens Health. 2020 Nov 26 ;20(1):262. Epub 2020 Nov 26. PMID: 33243209

Article Published Date : Nov 25, 2020

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Dyspepsia, Helicobacter Pylori Infection

Pharmacological Actions : Gastrointestinal Agents

[+]

Additional Keywords : Superiority of Natural Substances versus Drugs

Problem Substances : Antidepressants

[+]

Melatonin, quercetin and NAC are beneficial in reducing oxidative stress in the patients with Grave's Disease. Sep 01, 2005

Click here to read the entire abstract

Pubmed Data : Pharmazie. 2005 Sep;60(9):696-700. PMID: 16222871

Article Published Date : Sep 01, 2005

Study Type : Human Study

Additional Links

Substances : Melatonin, NAC (N-acetyl-L-cysteine), Quercetin

Diseases : Graves Disease

Pharmacological Actions : Antioxidants

[+]

Mobile phone exposure may affect melatonin onset time.Feb 01, 2006

Click here to read the entire abstract

Pubmed Data : Int J Radiat Biol. 2006 Feb ;82(2):69-76. PMID: 16546905

Pubmed Data : Clin Nutr. 2020 01 ;39(1):291-297. Epub 2019 Feb 10. PMID: 30792141

Article Published Date : Dec 31, 2019

Study Type : Human Study

Additional Links

Substances : Melatonin, Tomato

Diseases : Obesity, Sleep Disorders

[+]

Supplementation with propolis and melatonin may improve clinical outcomes by reducing inflammation.Feb 24, 2022

Article Published Date : Dec 31, 2021

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Diabetic Nephropathy

Pharmacological Actions : Renoprotective

[+]

The efficacy of melatonin against radiotoxicity of iodine-131 and its response to treatment in hyperthyroid patients.Dec 31, 2021

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This pilot study suggests that the combination of melatonin, vitamin B6, and medicinal plants may be beneficial in mild-to-moderate insomnia.Jul 31, 2019

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Pubmed Data : Complement Ther Med. 2019 Aug ;45:104-108. Epub 2019 May 25. PMID: 31331545

Article Published Date : Jul 31, 2019

Study Type : Human Study

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Substances : Lemon Balm, Melatonin, Passion Flower, Poppy, Vitamin B-6

Diseases : Insomnia

Additional Keywords : Plant Extracts

[+]

This study hypothesized that the greater preservation of neurocognitive functions in the morning patients was associated with elevated melatonin levels.May 24, 2015

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Pubmed Data : Ann Thorac Cardiovasc Surg. 2015 May 25. Epub 2015 May 25. PMID: 26004111

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Pubmed Data : Radiat Environ Biophys. 2010 Nov ;49(4):731-41. Epub 2010 Jun 26. PMID: 20582429

Article Published Date : Nov 01, 2010

Study Type : Human In Vitro

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Substances : Melatonin

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants

Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation

Adverse Pharmacological Actions : Oxidant

[+]

Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion.Jan 17, 2019

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Pubmed Data : Stem Cell Res Ther. 2019 10 17 ;10(1):306. Epub 2019 Oct 17. PMID: 31623678

Article Published Date : Jan 17, 2019

Study Type : Human In Vitro

Additional Links

Substances : Antioxidant formulas, Glutathione, Melatonin

Pharmacological Actions : Antioxidant, Regenerative

[+]

Dose-dependent DNA damage resulting from mobile phone radiation is attentuated by pretreatment with melatonin in vitro.Nov 01, 2013

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Pubmed Data : Int J Radiat Biol. 2013 Nov ;89(11):993-1001. Epub 2013 Sep 3. PMID: 23952262

Article Published Date : Nov 01, 2013

Study Type : Human In Vitro

Melatonin alleviates renal injury in diabetic rats by regulating autophagy.Oct 31, 2023

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Pubmed Data : Mol Med Rep. 2023 Nov ;28(5). Epub 2023 Sep 29. PMID: 37772370

Article Published Date : Oct 31, 2023

Study Type : Animal Study, In Vitro Study

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Substances : Melatonin

Diseases : Diabetes Mellitus: Type 2, Oxidative Stress

Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Glutathione Upregulation , Superoxide Dismutase Up-regulation

[+]

Melatonin attenuates bisphenol A-induced colon injury.Jan 31, 2023

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Pubmed Data : Free Radic Biol Med. 2023 Feb 1 ;195:13-22. Epub 2022 Dec 19. PMID: 36549428

Article Published Date : Jan 31, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Melatonin

Diseases : Bisphenol Toxicity

Pharmacological Actions : Antioxidants, Gastroprotective, Nrf2 activation

Problem Substances : Bisphenol A

Adverse Pharmacological Actions : Gastrotoxic

[+]

Melatonin attenuates chronic intermittent hypoxia-induced intestinal barrier dysfunction in mice.Oct 31, 2023

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Pubmed Data : Ecotoxicol Environ Saf. 2023 Mar 15 ;253:114674. Epub 2023 Feb 22. PMID: 36827899

Article Published Date : Mar 14, 2023

Study Type : Animal Study, In Vitro Study

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Substances : Melatonin

Diseases : Chemically-Induced Liver Damage, Fluoride Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Sodium Fluoride

[+]

Melatonin ameliorates microvessel abnormalities in the cerebral cortex and hippocampus in a model of Alzheimer's disease.Mar 31, 2021

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Pubmed Data : Cell J. 2016 ;18(1):46-51. Epub 2016 Apr 4. PMID: 27054118

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Melatonin, Vitamin C

Diseases : Chemotherapy and Radiation Toxicity

Pharmacological Actions : Radioprotective

Additional Keywords : Natural Substance Synergy

Anti Therapeutic Actions : Radiotherapy

[+]

Administration of melatonin, retinoic acid and Nigella sativa reduced the carcinogenic effects of DMBA.Nov 30, 2005

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Pubmed Data : Int J Exp Pathol. 2005 Dec ;86(6):383-96. PMID: 16309544

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Pubmed Data : J Acupunct Meridian Stud. 2021 Oct 31 ;14(5):176-182. PMID: 35770586

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Pubmed Data : Eur Rev Med Pharmacol Sci. 2024 Mar ;28(5):1920-1930. PMID: 38497875

Article Published Date : Feb 29, 2024

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Hypothyroidism

Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Effects of melatonin against experimentally induced apical periodontitis in rats.Mar 20, 2024

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Pubmed Data : Aust Endod J. 2024 Mar 21. Epub 2024 Mar 21. PMID: 38509787

Article Published Date : Mar 20, 2024

Study Type : Animal Study

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Substances : Melatonin

Diseases : Periodontitis

Pharmacological Actions : Anti-Inflammatory Agents, Osteoprotective

[+]

Effects of melatonin and metformin on the ovaries of rats with polycystic ovary syndrome.Mar 11, 2024

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Pubmed Data : Okajimas Folia Anat Jpn. 2002 May ;79(1):25-31. PMID: 12199535

Article Published Date : May 01, 2002

Study Type : Animal Study

Additional Links

Substances : Melatonin

Pharmacological Actions : Radioprotective

Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation

Adverse Pharmacological Actions : Cytotoxic, Hepatotoxic

[+]

Melatonin abated bisphenol A-induced neurotoxicity via p53/PUMA/Drp-1 signaling.Jan 04, 2021

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Pubmed Data : Environ Sci Pollut Res Int. 2021 Jan 5. Epub 2021 Jan 5. PMID: 33398767

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2015;2015:703709. Epub 2015 Jun 21. PMID: 26185593

Article Published Date : Dec 31, 2014

Study Type : Animal Study, In Vitro Study

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Substances : Melatonin

Diseases : Acrylamide-induced toxicity, Oxidative Stress

Pharmacological Actions : Antioxidants, Chemopreventive

Additional Keywords : Risk Reduction

Problem Substances : Acrylamide

[+]

Melatonin alleviated fluoride-induced impairment of spermatogenesis and sperm maturation process.Jul 31, 2023

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Pubmed Data : Food Chem Toxicol. 2023 Aug ;178:113867. Epub 2023 Jun 1. PMID: 37269891

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Pubmed Data : Int J Mol Sci. 2023 Sep 3 ;24(17). Epub 2023 Sep 3. PMID: 37686424

Article Published Date : Sep 02, 2023

Study Type : Animal Study

Additional Links

Substances : Melatonin

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Microplastic

Problem Substances : Polyethylene

Adverse Pharmacological Actions : Gastrotoxic

[+]

Melatonin alleviates lipopolysaccharide induced blood-brain barrier disruption.Feb 02, 2017

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Pubmed Data : Gastroenterol Res Pract. 2022 ;2022:6920577. Epub 2022 Mar 17. PMID: 35340691

Article Published Date : Dec 31, 2021

Study Type : Animal Study

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Substances : Melatonin

Diseases : Necrotising enterocolitis

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Melatonin alleviates oxidative stress damage in mouse testes induced by bisphenol A.Dec 31, 2023

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Pubmed Data : Front Cell Dev Biol. 2024 ;12:1338828. Epub 2024 Feb 19. PMID: 38440074

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Pubmed Data : Neuroreport. 2020 Nov 5. Epub 2020 Nov 5. PMID: 33165196

Article Published Date : Nov 04, 2020

Study Type : Animal Study

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Substances : Melatonin

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

[+]

Melatonin ameliorated sodium fluoride-induced testicular metabolic stress.Dec 10, 2019

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Pubmed Data : Biol Trace Elem Res. 2019 Dec 11. Epub 2019 Dec 11. PMID: 31828722

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Pubmed Data : Ecotoxicol Environ Saf. 2022 Aug ;241:113803. Epub 2022 Jun 29. PMID: 36068739

Article Published Date : Jul 31, 2022

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Glyphosate Toxicity, Kidney Damage: Chemically-Induced

Pharmacological Actions : Renoprotective

Problem Substances : Glyphosate

[+]

Melatonin ameliorates symptoms of kidney damage in rats. Nov 01, 2005

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Pubmed Data : J Agric Food Chem. 2000 Nov;48(11):5630-9. PMID: 19159082

Article Published Date : Nov 01, 2000

Study Type : Animal Study

Additional Links

Substances : Glandulars, Melatonin

Diseases : Fluoride Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

Melatonin and caffeic acid phenethyl ester prevent renal tubular injury by reducing oxidative stress and protect the kidney from oxidative damage induced by 900 MHz mobile phone.Aug 01, 2005

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Pubmed Data : Mol Cell Biochem. 2005 Aug ;276(1-2):31-7. PMID: 16132682

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Pubmed Data : Nano Res. 2022 Nov 15 ;16(2):2885-2894. PMID: 37207041

Article Published Date : Nov 14, 2022

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Pubmed Data : J Int Med Res. 2020 Oct ;48(10):300060520952656. PMID: 33081548

Article Published Date : Sep 30, 2020

Study Type : Animal Study

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Substances : Melatonin

Diseases : Aflatoxicosis

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective

Problem Substances : Aflatoxin

[+]

Melatonin attenuates affective disorders and cognitive deficits induced by perinatal exposure to a glyphosate-based herbicide.Sep 02, 2024

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Pubmed Data : Int J Dev Neurosci. 2024 Sep 3. Epub 2024 Sep 3. PMID: 39224983

Article Published Date : Sep 02, 2024

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Cognitive Decline/Dysfunction, Glyphosate Toxicity

Pharmacological Actions : Antioxidants

Problem Substances : Glyphosate

[+]

Melatonin attenuates bisphenol A-induced toxicity of the adrenal gland of Wistar rats.Jan 05, 2019

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Pubmed Data : Environ Sci Pollut Res Int. 2019 Jan 6. Epub 2019 Jan 6. PMID: 30613877

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Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:3528274. Epub 2016 Apr 6. PMID: 27143993

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Diabetic Retinopathy

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Melatonin can help protect against Wi-Fi-induced oxidative stress in the lens of rats.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Indian J Ophthalmol. 2014 Jan ;62(1):12-5. PMID: 24492496

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants

Anti Therapeutic Actions : Electromagnetic Field Harms, Wi-Fi Radiation

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View the Evidence: 908 Abstracts with Melatonin Research

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Adjunctive melatonin supplementation can significantly improve the periodontal status after non-surgical treatment.Mar 14, 2022

Melatonin receptor agonists for the prevention of delirium.May 05, 2022

Protective effects of exogenous melatonin therapy against oxidative stress to male reproductive tissue caused by anti-cancer chemical and radiation therapy.Dec 31, 2022

The therapeutic effect of exogenous melatonin on depressive symptoms.Dec 31, 2021

This systematic review found that add-on melatonin therapy improved sleep latency and seizure severity in patients with epilepsy.Feb 22, 2024

Effects of melatonin supplementation on oxidative stress.Nov 10, 2020

Melatonin could have an effect on body weight. Nov 28, 2016

Melatonin intake was shown to have a significant impact on improving oxidative stress parameters.Sep 28, 2020

Melatonin is effective in advancing sleep-wake rhythm and endogenous melatonin rhythm in delayed sleep phase disorder.Dec 01, 2010

Melatonin may decrease the incidence of delirium for special ICU patients.Mar 21, 2024

Melatonin reduces the risk of death from cancer. Nov 01, 2005

Melatonin supplementation had a significant preventive effect in decreasing the incidence of delirium in elderly patients.Jul 20, 2015

Perioperative melatonin reduced the incidence of delirium in older adults in the included studies. Oct 15, 2019

Protective effects of melatonin against severe burn-induced distant organ injury.Nov 26, 2020

The current meta-analysis supports the use of melatonin for anti-nociception.Nov 20, 2017

There is evidence that melatonin treatment after traumatic brain injury significantly improves both behavioural outcomes and pathological outcomes.Jun 13, 2018

This meta-analysis clearly supports the use of melatonin as a management for patients with secondary sleep disorders.Jun 13, 2018

This meta-analysis provided some evidence that melatonin improves sleep quality in patients with AD and PD.Aug 08, 2015

This meta-analysis showed the promising effect of melatonin administration on reducing CRP and IL-6 among patients with MetS and related disorders.Jun 14, 2018

Lower Melatonin Indicates poor short-term prognosis in patients with acute ischemic stroke.Mar 07, 2024

A dietary supplement containing melatonin, l-tryptophan, vitamin B6, folic acid, vitamin B12, methionine and betaine, is superior to omeprazole in treating GERD. Oct 01, 2006

A low physiological dose of melatonin (.5 mg) is almost effective as a pharmacological dose of 5.0 mg in alleviating jet lag. Nov 01, 1998

A pilot study on the melatonin treatment in patients with early septic shock.Jul 31, 2022

Adjuvant use of melatonin may help to reduce thrombosis, sepsis, and mortality in COVID-19 patients.Dec 31, 2021

Administration of melatonin as an adjuvant therapy in the treatment of neonatal sepsis is associated with improvement of clinical and laboratory outcomes.Oct 08, 2015

Administration of melatonin, alone or in a combination with fluoxetine was effective in the treatment of patients with fibromyalgia.Mar 31, 2011

Antioxidant effect of melatonin in preterm newborns. Dec 31, 2020

Application of melatonin cream 12.5% protects against natural sunlight induced erythema.Aug 08, 2016

Beneficial effect of melatonin on blood loss after cesarean section.Sep 30, 2019

Both melatonin and light treatment have positive effects on various sleep outcomes.Oct 09, 2016

Bright light treatment in elderly patients with major depressive disorder improved mood, enhanced sleep efficiency and increased melatonin level.Dec 31, 2010

Circadian melatonin disruption can be used as an indicator of delirium.Sep 30, 2016

Coadministration of melatonin with olanzapine in adolescents with bipolar disorder could reduce the sharp weight gain side effect.Mar 23, 2017

Combined treatment including melatonin resulted in the improvement of general conditions in 81.7% of the patientsDec 31, 2012

Comparison of the effect of melatonin, dexmedetomidine, and gabapentin on reduction of postoperative pain and anxiety following laminectomy.Oct 14, 2022

Complementary and alternative medicine (CAM) in headache of children and adolescents.Dec 31, 2019

Dietary melatonin therapy alleviates the lamina cribrosa damages in patients with mild cognitive impairments.May 06, 2020

Disruption of melatonin circadian rhythm production is frequent among RRMS patients and seemingly related to higher disability and fatigue scores.Jun 14, 2015

Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients.Jan 31, 2023

Effects of a nighttime melatonin ingestion on dynamic postural balance and muscle strength the following morning in people living with multiple sclerosis.Feb 29, 2024

Effects of melatonin alone or associated with acyclovir on the suppressive treatment of recurrent genital herpes.Apr 03, 2023

Effects of melatonin on postoperative delirium.Oct 20, 2021

Effects of melatonin on sleep disturbances in multiple sclerosis.Sep 30, 2021

Effects of melatonin prolonged-release on both sleep and motor symptoms in Parkinson's disease: a preliminary evidence.May 09, 2022

Effects of short-term intake of montmorency tart cherry juice on sleep quality after intermittent esleep disxercise.Aug 17, 2022

Efficacy of melatonin administration in reducing headaches in children with migraines without sleep disorders.Dec 31, 2023

Efficacy of melatonin for sleep disturbance in middle-aged primary insomnia.Oct 16, 2020

Elevated melatonin during mania and elevated cortisol during depression may characterize bipolar disorder. May 01, 1989

Exercise-induced Human Growth Hormone secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjects.Jul 01, 1999

Exogenous melatonin reverses the enhanced oxidative damage to membrane lipids and improves skin biophysical characteristics in former-smokers.Dec 22, 2017

Geomagnetic activity may play a role in the entrainment of human melatonin rhythms.Jun 12, 2008

High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults.Jul 31, 2022

Higher urinary melatonin levels were associated with reduced breast cancer risk in this cohort of postmenopausal women.Nov 08, 2016

Long-term usage of melatonin even after completion of adjuvant therapies in women with breast cancer decreased the levels of fatigue.Dec 31, 2022

Low-dose melatonin for sleep disturbances in early-stage cirrhosis.Jul 31, 2020

Lower serum levels of melatonin in ovarian cancer patients which may contribute to the pathogenesis of ovarian cancer.Dec 31, 2015

Meditation results in acute increases in night-time plasma melatonin levels.May 01, 2000

Melatonin 10 mg daily may lead to a statistically significant faster resolution of covid symptoms.Dec 31, 2021

Melatonin administrated before an evening test meal improved glucose tolerance, insulin sensitivity and reduced postprandial TAGs.Nov 30, 2021

Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease.Dec 11, 2017

Melatonin and L-Tryptophan have a protective effect on acute pancreatitisJan 01, 2003

Melatonin and oxidative stress in melasma - an unexplored territory; a prospective study.Mar 04, 2020

Melatonin and to a lesser degree mothewort decrease retinal sensitivity and improves the emotional state in anxious young subjects.Nov 01, 2006

Melatonin and vitamin E may be safe and effective in patients with systemic sclerosis. Nov 01, 2010

Melatonin appears to be effective in the treatment of sleep disturbances, as well as improving behavioral measures in children with Asperger disorder. Dec 01, 2009

Melatonin as preemptive analgesic for intraoperative pain.Dec 31, 2022

Melatonin can alleviate jet lag and tiredness after long haul flights.Mar 18, 1989

Melatonin can be considered a safe and effective treatment for nocturia in elderly women.Jan 31, 2023

Melatonin can modulate the inflammatory actions in periodontal patients.Nov 30, 2015

Melatonin could be effective and safe for decreasing daytime seizure frequency in patients with intractable epilepsy.Feb 28, 2012

Melatonin could be used in migraine prophylaxis treatments. Dec 31, 2017

Melatonin could decrease fatigue in survivors of aneurysmal subarachnoid hemorrhage.Nov 15, 2016

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View the Evidence:
908 Abstracts with Melatonin Research