Melatonin

Name	AC	CK
Oxidative Stress	78	203
Breast Cancer	41	86
Sleep Disorders	7	74
Inflammation	23	66
Alzheimer's Disease	25	62
Delirium	4	51
Circadian Dysregulation	8	46
Insomnia	5	42
Parkinson's Disease	10	40
Hormone Imbalances: Low Melatonin	7	38
Neurodegenerative Diseases	14	38
Diabetes Mellitus: Type 2	8	32
Lipid Peroxidation	12	32
Chemotherapy and Radiation Toxicity	9	31
C-Reactive Protein	2	30
Tinnitus	3	30
Cancers: All	8	27
Brain Injury: Traumatic	5	26
Aging	14	25
Headache	6	24
Prostate Cancer	5	24
Chronic Pain	4	23
Jet Lag	4	23
Bisphenol Toxicity	14	22
Metabolic Syndrome X	2	22
Obesity	12	22
Gastroesophageal Reflux	3	21
Headache: Migraine	3	21
Liver Cancer	12	21
Muscle Damage: Exercise-Induced	3	21
Burns	1	20
Delayed Sleep Phase Disorder	1	20
Depressive Disorder	2	20
Multiple Sclerosis: Relapsing-Remitting	2	20
Overweight	1	20
Purpura: Thrombocytopenic	2	20
Thrombocytopenia	2	20
Aging: Brain	9	18
Cognitive Decline/Dysfunction	5	18
Multiple Sclerosis	7	18
Osteoporosis	5	17
DNA damage	8	16
Depression	10	16
Testicular Injury: Chemical/Metal Induced	9	16
Ovarian Cancer	5	15
Brain: Oxidative Stress	8	14
Chemically-Induced Liver Damage	3	14
Epilepsy	4	14
Sepsis	4	14
Aging Skin	3	13
Aluminum Toxicity	7	13
Colorectal Cancer	4	13
Fibromyalgia	3	13
Infertility: Male	6	13
Lipopolysaccharide-Induced Toxicity	6	13
Autism	2	12
Breast Cancer: Metastatic	2	12
Chemotherapy-Induced Toxicity: Cyclophosphamide	2	12
Nocturia	2	12
Periodontal Diseases	3	12
Scoliosis	2	12
Anxiety Disorders	2	11
Benzo[a]pyrene-induced Toxicity	2	11
Bipolar Disorder	2	11
Pancreatitis	2	11
Radiation Induced Illness	6	11
Skin Diseases	2	11
Abdominal Obesity (Midsection Fat)	1	10
Aneurysmal subarachnoid hemorrhage (SAH)	1	10
Asperger Syndrome	1	10
Athletic Performance	1	10
Bone Fractures	1	10
Brain Inflammation	6	10
Cardiac Surgery	1	10
Cesarean Section	1	10
Chronic Fatigue Syndrome	1	10
Cirrhosis	1	10
Coronary Artery Disease	1	10
Coronary Bypass Surgery	1	10
Cortisol: High	1	10
Depression: Breast Cancer Related	1	10
Dyspepsia	1	10
Erythema	1	10
Female	1	10
Graves Disease	1	10
Helicobacter Pylori Infection	1	10
Hemodialysis	1	10
Human Growth Hormone: Enhancement	1	10
Melasma	1	10
Mitochondrial Dysfunction	6	10
Oral Mucositis	1	10
Osteopenia	1	10
Retinal Diseases	1	10
Retinal Sensitivity	1	10
Sclerosis: Systemic	1	10
Skin Diseases: Photo-Aging	1	10
Spinal Cord Injuries	5	10
Weight Gain: Drug-Induced	1	10
Anxiety	6	9
Diabetic Nephropathy	5	9
Infertility	3	9
Osteosarcoma	5	9
Cancer Metastasis	4	8
Liver Injury: Ischemia/reperfusion	5	8
Mobile Phone-Induced Oxidative Stress	4	8
Periodontitis	4	8
Stroke: Ischemic	4	8
Hypertension	4	7
Myocardial Infarction	4	7
Sperm Quality: Low	2	7
Cadmium Poisoning	4	6
Cardiovascular Diseases	5	6
Endothelial Dysfunction	4	6
High Fat Diet	3	6
High Fructose Diet	3	6
Insulin Resistance	3	6
Kidney Damage	3	6
Kidney Damage: Drug-Induced	3	6
Lung Cancer	2	6
Myocardial Ischemia	3	6
Stress	3	6
Stroke: Attenuation/Recovery	5	6
Cervical Cancer	4	5
Chemotherapy-Induced Toxicity: Doxorubicin	3	5
Coronavirus Infection	4	5
Endometriosis	3	5
Huntington Disease	4	5
Neuroblastoma	1	5
Osteoporosis: Inflammation Induced	1	5
Pancreatic Cancer	4	5
Ultraviolet Radiation Induced Damage	4	5
Aging: Immunosenecence	3	4
Air Pollution Linked Toxicity	2	4
Alcohol Toxicity	2	4
Alcoholic Liver Disease	2	4
Amyotrophic Lateral Sclerosis	4	4
Breast Cancer: Triple Negative	3	4
Cerebral Hypoperfusion	2	4
Cerebral Ischemia	2	4
Chemotherapy-Induced Toxicity	3	4
Chemotherapy-Induced Toxicity: Cisplatin	2	4
Chemotherapy-Induced Toxicity: Gentamicin	2	4
Colitis	2	4
Colon Cancer	4	4
Diabetic Retinopathy	2	4
Drug-Induced Toxicity: Methotrexate	2	4
Dysbiosis	2	4
Electromagnetic Radiation Mitigation	2	4
Encephalitis	2	4
Fluoride Toxicity	3	4
Glioblastoma	4	4
Glyphosate Toxicity	2	4
Hypertension: Pulmonary	2	4
Hypoxia	2	4
Ischemia	3	4
Kidney Diseases	2	4
Leukemia	3	4
Liver Fibrosis	2	4
Lung Injury: Acute	3	4
Memory Disorders	2	4
Metabolic Diseases	2	4
Neonatal Stroke	2	4
Nicotine/Tobacco Toxicity	3	4
Pesticide Toxicity	2	4
Pregnancy Complications	2	4
Arsenic Poisoning	2	3
Brain Damage	2	3
Brain Ischemia	2	3
Breast Cancer: Estrogen	3	3
Breast Cancer: estrogen receptor alpha-positive	2	3
Gastric Ulcer	2	3
Irritable Bowel Syndrome	3	3
Liver Damage	2	3
Liver Disease	2	3
Osteoarthritis	2	3
Pituitary Tumours	2	3
Psychiatric Disorders	2	3
Schizophrenia	2	3
Systemic Lupus Erythematosus	3	3
Ulcerative Colitis	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Acrylamide-induced toxicity	1	2
Aflatoxicosis	1	2
Aging: Heart	1	2
Amnesia	1	2
Amyotrophic lateral sclerosis (ALS)	2	2
Atherosclerosis	1	2
Autism Spectrum Disorders	2	2
Autoimmune Diseases	2	2
Benzene Toxicity	1	2
Bile Duct Injury	1	2
Bone Diseases	1	2
Breast Cancer: Lung Metastasis	1	2
Cancer: Prostate	1	2
Cardiac Hypertrophy	1	2
Cardiomyopathy	1	2
Cataract: Radiation-Induced	1	2
Cell Phone Induced Disease	1	2
Chemotherapy-Induced Kidney Damage	1	2
Chemotherapy-Induced Toxicity: Epirubicin	1	2
Chemotherapy-Induced Toxicity: Oxaliplatin	1	2
Chronic Kidney Disease (CKD)	2	2
Cocaine Addiction	1	2
Cocaine Withdrawal	1	2
Colon Cancer: Prevention	1	2
Cough	1	2
Coxsackievirus Infections	1	2
Degenerative Disk Disease	1	2
Dementia	1	2
Demyelinating Diseases	1	2
Depression	1	2
Depression: Stress Related	1	2
Diabetes	1	2
Diabetes Mellitus: Type 1	2	2
Diabetes: Cognitive Dysfunction	1	2
Diabetes: Oxidative Stress	1	2
Diabetic Complications	1	2
Drug-Induced Toxicity: Bisphosphonates	1	2
Drug-Induced Toxicity: Indomethacin	1	2
Edema	1	2
Endometrial Cancer	1	2
Estrogen Deficiency	1	2
Fructose-Induced Toxicity	1	2
Gastric Cancer	2	2
Glaucoma	3	2
Gliomas	1	2
Glutathione Deficiency	1	2
HIV Drug-Induced Toxicity	1	2
Headache: Cluster	2	2
Heart Disease	1	2
Herbicide Toxicity	1	2
High Homocysteine	1	2
High Sugar Diet	1	2
Hydrogen Peroxide Induced Toxicity	2	2
Hyperalgesia	1	2
Hyperbilirubinemia: Hereditary	1	2
Hypercholesterolemia	1	2
Hyperglycemia	1	2
Hyperlipidemia	1	2
Hyperthyroidism	1	2
Hypoxia: Brain	1	2
Immune Disorders: Low Immune Function	1	2
Inflammation: Brain	1	2
Intestinal Ischemia	1	2
Kidney Damage: Chemically-Induced	1	2
Kidney Failure	1	2
Kidney Fibrosis	2	2
Leiomyosarcoma	1	2
Liver Cirrhosis	1	2
Low Immune Function: Natural Killer Cells	1	2
Macular Degeneration	3	2
Malaria	1	2
Melanoma	2	2
Morphine Tolerance/Dependence	1	2
Multi-Organ Failure	1	2
Myocarditis: Viral	1	2
Neural Tube Defects	1	2
Neuralgia: Post Herpetic	1	2
Neuritis: Brachial Plexus	1	2
Obstructive Nephropathy	1	2
Optic Neuritis	1	2
Oral Cancer	2	2
Ovariectomy Associated Adverse Changes	1	2
Plasmodium Infections	1	2
Prediabetes	1	2
Prenatal Chemical Exposures	1	2
Prenatal Nutrition: Prevention of Problems	1	2
Quality of Life: Poor	1	2
Radiation	1	2
Radiation-Induced Illness: Cesium-137 Exposure	1	2
Sciatic Nerve Crush Injury	1	2
Sleep Apnea: Central	1	2
Snake Bite: Venom Toxicity	1	2
Squamous cell carcinoma	2	2
Subarachnoid hemorrhage	2	2
Testicular Injury: Formaldehyde-Induced	1	2
Testicular Injury: Nicotine-Induced	1	2
Traumatic Brain Injury	1	2
Tumors	2	2
Vaginal Cancer	1	2
Wound Healing	1	2
Acute Respiratory Distress Syndrome	1	1
Acute T cell Leukemias	1	1
Amphetamine Addiction/Withdrawal	1	1
Animal Cancers	1	1
Asphyxia	1	1
Brain Edema	1	1
Cancers: Drug Resistant	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Chemotherapy-Induced Toxicity: Arsenic Trioxide	1	1
Chronic Disease	1	1
Crohn's Disease	1	1
Ebola Virus Infections	1	1
Encephalopathy: Hypoxic	1	1
Endocrine Diseases	1	1
Esophageal Cancer	1	1
Estrogen Dominance	1	1
Fractures: Bone	1	1
Fragile X Syndrome	1	1
Gallbladder Inflammation	1	1
Gallstones	1	1
Gastritis	1	1
Glioma	1	1
Head and Neck Cancer	1	1
Heavy Metal Toxicity	1	1
Inflammatory Bowel Diseases	1	1
Leiomyoma	1	1
Liver Damage: Aflatoxin-Induced	1	1
Lung Injury: Smoke-Induced	1	1
Lymphoma: B-Cell	1	1
Mastitis	1	1
Migraine Disorders	1	1
Migraines	1	1
Mitochondrial Diseases	1	1
Mood Disorders	1	1
Myasthenia Gravis	1	1
Napthalene-Induced Toxicity	1	1
Nasopharyngeal Cancer	1	1
Non-Small-Cell Lung Carcinoma	1	1
Organ Transplantation	1	1
Organ Transplantation: Liver	1	1
Osteoarthritis: Knee	1	1
Pancreatic Diseases	1	1
Photooxidative Stress	1	1
Pineal Gland Calcification	1	1
Pineal Gland Diseases	1	1
Post-Traumatic Stress Disorders (PTSD)	1	1
Proliferative Vitreoretinopathy (PVR)	1	1
Prostatic Hyperplasia: Benign	1	1
Pulmonary Fibrosis	1	1
Renal Cancer	1	1
Retinopathy of Prematurity	1	1
Rheumatoid Arthritis	1	1
Sarcoma: Ewing's	1	1
Septic Shock	1	1
Stroke: Hemorrhagic	1	1
Tongue Cancer	1	1
Vaccine-induced Toxicity	1	1
Wound Healing: Delayed	1	1
Abdominal Adhesions	1	0
Sarcoidosis	1	0

Name	AC	CK
Antioxidants	179	448
Anti-Inflammatory Agents	89	239
Neuroprotective Agents	97	216
Apoptotic	46	67
Tumor Necrosis Factor (TNF) Alpha Inhibitor	20	67
Anti-Apoptotic	36	61
Antiproliferative	41	60
Interleukin-6 Downregulation	7	45
Renoprotective	24	45
Hepatoprotective	24	44
Prophylactic Agents	7	44
Antidepressive Agents	10	43
Radioprotective	18	42
Cardioprotective	20	37
NF-kappaB Inhibitor	20	32
Anti-metastatic	22	29
Brain-derived neurotrophic factor modulator	4	26
Hypoglycemic Agents	5	26
Malondialdehyde Down-regulation	9	26
Chemosensitizer	19	24
Interleukin-1 beta downregulation	12	23
Regenerative	7	23
Cyclooxygenase 2 Inhibitors	11	22
Immunomodulatory	17	22
Secretagogue	3	22
Cytoprotective	12	21
Gastrointestinal Agents	7	21
Antinoceceptive	1	20
Chemoprotective Agents	11	19
Chemotherapeutic	10	19
Nrf2 activation	13	19
Osteogenic	4	19
Tumor Suppressor Protein p53 Upregulation	15	18
Angiogenesis Inhibitors	8	14
Insulin Sensitizers	2	12
Matrix metalloproteinase-9 (MMP-9) inhibitor	10	12
Superoxide Dismutase Up-regulation	7	12
Chemopreventive	7	11
Genoprotective	5	11
Proton Pump Inhibitor	2	11
Adiponectin upregulation	1	10
Anxiolytic	1	10
Bcl-2 protein down-regulation	7	10
Gastroprotective	6	10
Hypnotics and Sedatives	1	10
Insulin-Like Growth Factor Inhibition/Downregulation	1	10
Matrix metalloproteinase-2 (MMP-2) inhibitor	5	10
Vasodilator Agents	1	10
Anticarcinogenic Agents	5	9
Antineoplastic Agents	7	9
Antioxidant	3	9
Antihypertensive Agents	5	8
Cell cycle arrest	8	8
Hypolipidemic	4	8
Vascular Endothelial Growth Factor Inhibitors	4	8
Heme oxygenase-1 up-regulation	6	7
MicroRNA modulator	6	7
Analgesics	5	6
Anti-Anxiety Agents	4	6
Autophagy Inhibitors	4	6
Nitric Oxide Inhibitor	1	5
Prostaglandin PGE2 downregulation	1	5
Anti-Fibrotic	3	4
Antiviral Agents	3	4
Calcium Channel Blockers	2	4
Osteoprotective	3	4
Photoprotective	3	4
Radiosensitizer	4	4
Antimutagenic Agents	2	3
Aromatase Inhibitors	3	3
Autophagy Up-regulation	2	3
Caspase-3 Activation	2	3
DNA Repair Up-regulation	2	3
Detoxifier	2	3
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	3	3
Immunostimulatory	3	3
Acetylcholinesterase Inhibitor	1	2
Adenosine Monophosphate (AMP)-activated Protein Kinase (AMPK	1	2
Anti-Angiogenic	2	2
Anti-Proliferative	1	2
Anti-Ulcer Agents	1	2
Anticholesteremic Agents	1	2
Anticonvulsants	1	2
BRCA-1 Downregulation	2	2
Fertility Agents	1	2
Fertility Agents: Male	1	2
Heat Shock Protein Down-Regulation	1	2
Interleukin-10 downregulation	1	2
Interleukin-4 downregulation	1	2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	2
Matrix metalloproteinase-8 (MMP-8) inhibitor	1	2
Neurogenesis	1	2
Neuroplasticity enhancement	1	2
Neurorestorative	1	2
Receptor-Related Orphan Receptor (ROR)-Alpha1 Inhibitor	1	2
SIRT1 Activator	1	2
12-lipoxygenase (12-LOX) Inhibitor	1	1
Apaf-1/caspase-dependent apoptotic pathway activator	1	1
Bax/Bcl2 ratio: Increase	1	1
Caspase-9 Activation	1	1
Catalase Up-Regulation	1	1
Cell Differentiation Inducer	1	1
Chondroprotective	1	1
Cyclooxygenase Inhibitors	1	1
Drug synergy	1	1
Enzyme Inhibitors	1	1
Glutathione Upregulation	1	1
Immunomodulatory: Th17 downregulation	1	1
Interleukin-8 downregulation	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
P21 Activation	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
PI3K/Akt/signaling suppression	1	1
Selective estrogen enzyme modulator (SEEM)	1	1
Telomerase Inhibitor	1	1
Telomerase Upregulation	1	1
Transforming growth factor beta (TGF-β) inhibitor	1	1
Vascular Endothelial Growth Factor A Inhibitor	1	1
Wnt/β-catenin signaling pathway modulation	1	1
p300/NF-κB down-regulation	1	1

Click here to read the entire abstract

Pubmed Data : J Pineal Res. 2006 Oct;41(3):195-200. PMID: 16948779

Article Published Date : Oct 01, 2006

Study Type : Human Study

Additional Links

Substances : Betaine , Folic Acid , Melatonin, Methionine, Tryptophan, Vitamin B-12, Vitamin B-6

Diseases : Gastroesophageal Reflux

Pharmacological Actions : Proton Pump Inhibitor

Additional Keywords : Superiority of Natural Substances versus Drugs

[+]

Pharmacological Actions : Antidepressive Agents

[+]

Circadian melatonin disruption can be used as an indicator of delirium.Sep 30, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sleep Sci. 2016 Oct-Dec;9(4):285-288. Epub 2016 Aug 10. PMID: 28154742

Article Published Date : Sep 30, 2016

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Circadian Dysregulation, Delirium

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Coadministration of melatonin with olanzapine in adolescents with bipolar disorder could reduce the sharp weight gain side effect.Mar 23, 2017

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Pubmed Data : J Child Adolesc Psychopharmacol. 2017 Mar 24. Epub 2017 Mar 24. PMID: 28339282

Article Published Date : Mar 23, 2017

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Weight Gain: Drug-Induced

Additional Keywords : Risk Reduction

Problem Substances : Olanzapine

[+]

Combined treatment including melatonin resulted in the improvement of general conditions in 81.7% of the patientsDec 31, 2012

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Pubmed Data : Klin Med (Mosk). 2013 ;91(3):50-3. PMID: 23789453

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Pubmed Data : J Nerv Ment Dis. 1989 May;177(5):300-3. PMID: 2708973

Article Published Date : May 01, 1989

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Bipolar Disorder, Cortisol: High

[+]

Exercise-induced Human Growth Hormone secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjects.Jul 01, 1999

Diseases : C-Reactive Protein, Inflammation, Periodontal Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Melatonin could be effective and safe for decreasing daytime seizure frequency in patients with intractable epilepsy.Feb 28, 2012

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Pubmed Data : J Child Neurol. 2012 Feb 28. Epub 2012 Feb 28. PMID: 22378657

Article Published Date : Feb 28, 2012

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Epilepsy

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Melatonin could be used in migraine prophylaxis treatments. Dec 31, 2017

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Pubmed Data : Iran J Child Neurol. 2018 ;12(1):47-54. PMID: 29379562

Article Published Date : Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Breast Cancer Res Treat. 2014 Jun ;145(3):683-95. Epub 2014 Apr 23. PMID: 24756186

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Neurol Neurosurg Psychiatry. 2016 May 10. Epub 2016 May 10. PMID: 27165014

Article Published Date : May 09, 2016

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Headache: Migraine

Pharmacological Actions : Prophylactic Agents

Additional Keywords : Superiority of Natural Substances versus Drugs

Problem Substances : Antidepressants

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Melatonin, quercetin and NAC are beneficial in reducing oxidative stress in the patients with Grave's Disease. Sep 01, 2005

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Pubmed Data : Pharmazie. 2005 Sep;60(9):696-700. PMID: 16222871

Article Published Date : Sep 01, 2005

Study Type : Human Study

Additional Links

Substances : Melatonin, NAC (N-acetyl-L-cysteine), Quercetin

Diseases : Graves Disease

Pharmacological Actions : Antioxidants

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Mobile phone exposure may affect melatonin onset time.Feb 01, 2006

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Pubmed Data : Int J Radiat Biol. 2006 Feb ;82(2):69-76. PMID: 16546905

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Funct Neurol. 2016 Mar 8:1-5. Epub 2016 Mar 8. PMID: 26954506

Article Published Date : Mar 07, 2016

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Headache

Pharmacological Actions : Prophylactic Agents

Additional Keywords : Risk Reduction

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This pilot study suggests that the combination of melatonin, vitamin B6, and medicinal plants may be beneficial in mild-to-moderate insomnia.Jul 31, 2019

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Pubmed Data : Complement Ther Med. 2019 Aug ;45:104-108. Epub 2019 May 25. PMID: 31331545

Article Published Date : Jul 31, 2019

Study Type : Human Study

Additional Links

Substances : Lemon Balm, Melatonin, Passion Flower, Poppy, Vitamin B-6

Diseases : Insomnia

Additional Keywords : Plant Extracts

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This study hypothesized that the greater preservation of neurocognitive functions in the morning patients was associated with elevated melatonin levels.May 24, 2015

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Pubmed Data : Ann Thorac Cardiovasc Surg. 2015 May 25. Epub 2015 May 25. PMID: 26004111

Pubmed Data : J Altern Complement Med. 2004 Apr;10(2):261-8. PMID: 15165407

Article Published Date : Apr 01, 2004

Study Type : Human Study

Additional Links

Substances : Melatonin

Pharmacological Actions : Secretagogue

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50 Hz electromagnetic fields stimulate superoxide radical anion formation in human K562 cells which is attentuated by melatonin.Nov 01, 2010

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Pubmed Data : Radiat Environ Biophys. 2010 Nov ;49(4):731-41. Epub 2010 Jun 26. PMID: 20582429

Article Published Date : Nov 01, 2010

Study Type : Human In Vitro

Additional Links

Substances : Melatonin

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants

Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation

Adverse Pharmacological Actions : Oxidant

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Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion.Jan 17, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Stem Cell Res Ther. 2019 10 17 ;10(1):306. Epub 2019 Oct 17. PMID: 31623678

Article Published Date : Jan 17, 2019

Study Type : Human In Vitro

Additional Links

Substances : Antioxidant formulas, Glutathione, Melatonin

Pharmacological Actions : Antioxidant, Regenerative

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Dose-dependent DNA damage resulting from mobile phone radiation is attentuated by pretreatment with melatonin in vitro.Nov 01, 2013

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Pubmed Data : Int J Radiat Biol. 2013 Nov ;89(11):993-1001. Epub 2013 Sep 3. PMID: 23952262

Article Published Date : Nov 01, 2013

Study Type : Human In Vitro

Anti Therapeutic Actions : Radiotherapy

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Administration of melatonin, retinoic acid and Nigella sativa reduced the carcinogenic effects of DMBA.Nov 30, 2005

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Exp Pathol. 2005 Dec ;86(6):383-96. PMID: 16309544

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Pubmed Data : J Pineal Res. 2015 Jun 23. Epub 2015 Jun 23. PMID: 26103459

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Pubmed Data : Mol Neurobiol. 2017 Oct 30. Epub 2017 Oct 30. PMID: 29086246

Article Published Date : Oct 29, 2017

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Obesity

Pharmacological Actions : Neuroprotective Agents

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Daytime blue light enhances the nighttime circadian melatonin inhibition of human prostate cancer growth.Dec 31, 2014

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Pubmed Data : Comp Med. 2015 ;65(6):473-85. PMID: 26678364

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Pubmed Data : J Altern Complement Med. 2001 Jun;7(3):241-51. PMID: 11439845

Article Published Date : Jun 01, 2001

Study Type : Animal Study

Additional Links

Substances : Echinacea, Melatonin

Diseases : Immune Disorders: Low Immune Function, Leukemia, Low Immune Function: Natural Killer Cells

Pharmacological Actions : Immunomodulatory

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Effect of concomitant treatment of curcumin and melatonin on cisplatin-induced nephrotoxicity.Oct 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Okajimas Folia Anat Jpn. 2002 May ;79(1):25-31. PMID: 12199535

Article Published Date : May 01, 2002

Study Type : Animal Study

Additional Links

Substances : Melatonin

Pharmacological Actions : Radioprotective

Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation

Adverse Pharmacological Actions : Cytotoxic, Hepatotoxic

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Melatonin abated bisphenol A-induced neurotoxicity via p53/PUMA/Drp-1 signaling.Jan 04, 2021

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Pubmed Data : Environ Sci Pollut Res Int. 2021 Jan 5. Epub 2021 Jan 5. PMID: 33398767

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2015;2015:703709. Epub 2015 Jun 21. PMID: 26185593

Article Published Date : Dec 31, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Melatonin

Diseases : Acrylamide-induced toxicity, Oxidative Stress

Pharmacological Actions : Antioxidants, Chemopreventive

Additional Keywords : Risk Reduction

Problem Substances : Acrylamide

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Pubmed Data : J Agric Food Chem. 2000 Nov;48(11):5630-9. PMID: 19159082

Article Published Date : Nov 01, 2000

Study Type : Animal Study

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Substances : Glandulars, Melatonin

Diseases : Fluoride Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

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Melatonin and caffeic acid phenethyl ester prevent renal tubular injury by reducing oxidative stress and protect the kidney from oxidative damage induced by 900 MHz mobile phone.Aug 01, 2005

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Pubmed Data : Mol Cell Biochem. 2005 Aug ;276(1-2):31-7. PMID: 16132682

Pubmed Data : Toxicol Ind Health. 2018 May ;34(5):315-327. Epub 2018 Mar 21. PMID: 29562845

Article Published Date : May 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Int Med Res. 2020 Oct ;48(10):300060520952656. PMID: 33081548

Article Published Date : Sep 30, 2020

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Aflatoxicosis

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective

Problem Substances : Aflatoxin

[+]

Melatonin attenuates bisphenol A-induced toxicity of the adrenal gland of Wistar rats.Jan 05, 2019

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Pubmed Data : Environ Sci Pollut Res Int. 2019 Jan 6. Epub 2019 Jan 6. PMID: 30613877

Pubmed Data : Fertil Steril. 2008 Apr;89(4):934-42. Epub 2007 Jun 19. PMID: 17582405

Article Published Date : Apr 01, 2008

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Endometriosis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors

[+]

Pubmed Data : Alcohol Alcohol. 2016 Jan ;51(1):11-9. Epub 2015 Nov 11. PMID: 26564773

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Pubmed Data : Syst Biol Reprod Med. 2008 Jul-Aug;54(4-5):169-76. PMID: 18942024

Article Published Date : Jun 30, 2008

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Oxidative Stress, Testicular Injury: Formaldehyde-Induced

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

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Melatonin has a significant effect on the protection of the heart against isoproterenol induced myocardial infarction through maintaining endogenous antioxidant enzyme activities.Oct 09, 2010

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Pubmed Data : Eur J Pharmacol. 2010 Oct 10 ;644(1-3):160-8. Epub 2010 Jul 13. PMID: 20624385

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Pubmed Data : Eur Spine J. 2004 Dec;13(8):724-32. Epub 2004 Jul 1. PMID: 15232723

[+]

Melatonin is present in walnuts and can increase blood melatonin concentrations.Aug 31, 2005

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Pubmed Data : Nutrition. 2005 Sep ;21(9):920-4. PMID: 15979282

Article Published Date : Aug 31, 2005

Study Type : Animal Study

Additional Links

Substances : Melatonin, Walnut

Pharmacological Actions : Antioxidants

[+]

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Pubmed Data : Neuropeptides. 2019 Dec 25:102002. Epub 2019 Dec 25. PMID: 31902595

Article Published Date : Dec 24, 2019

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Spinal Cord Injuries

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Melatonin may be used as a probiotic agent to reverse sleep deprivation-induced small intestinal mucosa injury.Dec 09, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Arch Physiol Biochem. 2020 Nov 6:1-8. Epub 2020 Nov 6. PMID: 33156709

Article Published Date : Nov 05, 2020

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Pubmed Data : J Pineal Res. 2008 Mar;44(2):214-21. PMID: 18289174

Article Published Date : Mar 01, 2008

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Sleep Apnea: Central

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Melatonin may represent an effective treatment option for multiple sclerosis.Jun 26, 2015

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Pubmed Data : Brain Behav Immun. 2015 Jun 27. Epub 2015 Jun 27. PMID: 26130320

Article Published Date : Jun 26, 2015

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Multiple Sclerosis

Pharmacological Actions : Immunomodulatory

[+]

Melatonin may serve as an advanced strategy to strengthen oral health to counteract periodontitis induced destructive damage.Dec 22, 2017

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Pubmed Data : J Pineal Res. 2017 Dec 23. Epub 2017 Dec 23. PMID: 29274168

Article Published Date : Dec 22, 2017

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Periodontitis

Pharmacological Actions : Anti-Inflammatory Agents, Prophylactic Agents

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View the Evidence: 648 Abstracts with Melatonin Research

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Effects of melatonin supplementation on oxidative stress.Nov 10, 2020

Melatonin could have an effect on body weight. Nov 28, 2016

Melatonin intake was shown to have a significant impact on improving oxidative stress parameters.Sep 28, 2020

Melatonin is effective in advancing sleep-wake rhythm and endogenous melatonin rhythm in delayed sleep phase disorder.Dec 01, 2010

Melatonin reduces the risk of death from cancer. Nov 01, 2005

Melatonin supplementation had a significant preventive effect in decreasing the incidence of delirium in elderly patients.Jul 20, 2015

Perioperative melatonin reduced the incidence of delirium in older adults in the included studies. Oct 15, 2019

Protective effects of melatonin against severe burn-induced distant organ injury.Nov 26, 2020

The current meta-analysis supports the use of melatonin for anti-nociception.Nov 20, 2017

There is evidence that melatonin treatment after traumatic brain injury significantly improves both behavioural outcomes and pathological outcomes.Jun 13, 2018

This meta-analysis clearly supports the use of melatonin as a management for patients with secondary sleep disorders.Jun 13, 2018

This meta-analysis provided some evidence that melatonin improves sleep quality in patients with AD and PD.Aug 08, 2015

This meta-analysis showed the promising effect of melatonin administration on reducing CRP and IL-6 among patients with MetS and related disorders.Jun 14, 2018

A dietary supplement containing melatonin, l-tryptophan, vitamin B6, folic acid, vitamin B12, methionine and betaine, is superior to omeprazole in treating GERD. Oct 01, 2006

A low physiological dose of melatonin (.5 mg) is almost effective as a pharmacological dose of 5.0 mg in alleviating jet lag. Nov 01, 1998

Administration of melatonin as an adjuvant therapy in the treatment of neonatal sepsis is associated with improvement of clinical and laboratory outcomes.Oct 08, 2015

Administration of melatonin, alone or in a combination with fluoxetine was effective in the treatment of patients with fibromyalgia.Mar 31, 2011

Application of melatonin cream 12.5% protects against natural sunlight induced erythema.Aug 08, 2016

Beneficial effect of melatonin on blood loss after cesarean section.Sep 30, 2019

Both melatonin and light treatment have positive effects on various sleep outcomes.Oct 09, 2016

Bright light treatment in elderly patients with major depressive disorder improved mood, enhanced sleep efficiency and increased melatonin level.Dec 31, 2010

Circadian melatonin disruption can be used as an indicator of delirium.Sep 30, 2016

Coadministration of melatonin with olanzapine in adolescents with bipolar disorder could reduce the sharp weight gain side effect.Mar 23, 2017

Combined treatment including melatonin resulted in the improvement of general conditions in 81.7% of the patientsDec 31, 2012

Disruption of melatonin circadian rhythm production is frequent among RRMS patients and seemingly related to higher disability and fatigue scores.Jun 14, 2015

Efficacy of melatonin for sleep disturbance in middle-aged primary insomnia.Oct 16, 2020

Elevated melatonin during mania and elevated cortisol during depression may characterize bipolar disorder. May 01, 1989

Exercise-induced Human Growth Hormone secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjects.Jul 01, 1999

Exogenous melatonin reverses the enhanced oxidative damage to membrane lipids and improves skin biophysical characteristics in former-smokers.Dec 22, 2017

Geomagnetic activity may play a role in the entrainment of human melatonin rhythms.Jun 12, 2008

Higher urinary melatonin levels were associated with reduced breast cancer risk in this cohort of postmenopausal women.Nov 08, 2016

Low-dose melatonin for sleep disturbances in early-stage cirrhosis.Jul 31, 2020

Lower serum levels of melatonin in ovarian cancer patients which may contribute to the pathogenesis of ovarian cancer.Dec 31, 2015

Meditation results in acute increases in night-time plasma melatonin levels.May 01, 2000

Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease.Dec 11, 2017

Melatonin and L-Tryptophan have a protective effect on acute pancreatitisJan 01, 2003

Melatonin and oxidative stress in melasma - an unexplored territory; a prospective study.Mar 04, 2020

Melatonin and to a lesser degree mothewort decrease retinal sensitivity and improves the emotional state in anxious young subjects.Nov 01, 2006

Melatonin and vitamin E may be safe and effective in patients with systemic sclerosis. Nov 01, 2010

Melatonin appears to be effective in the treatment of sleep disturbances, as well as improving behavioral measures in children with Asperger disorder. Dec 01, 2009

Melatonin can alleviate jet lag and tiredness after long haul flights.Mar 18, 1989

Melatonin can modulate the inflammatory actions in periodontal patients.Nov 30, 2015

Melatonin could be effective and safe for decreasing daytime seizure frequency in patients with intractable epilepsy.Feb 28, 2012

Melatonin could be used in migraine prophylaxis treatments. Dec 31, 2017

Melatonin could decrease fatigue in survivors of aneurysmal subarachnoid hemorrhage.Nov 15, 2016

Melatonin deficiency may play a role in the pathogenesis of adolescent idiopathic scoliosis - Article 2. Apr 01, 2009

Melatonin exerts beneficial effects in MS patients based on its' proved antioxidative properties.Mar 31, 2016

Melatonin has a drug sparing and synergistic effect with chemotherapy in the treatment of metastatic colorectal patients. Mar 01, 2003

Melatonin has a role in the improvement of gastroesophageal reflux disease.Jan 01, 2010

Melatonin has been demonstrated to slow the proliferation of hormone-refractory prostate cancer in animal and human studies. Oct 01, 2003

Melatonin increases overall survival of prostate cancer patients with poor prognosis after combined hormone radiation treatment.Oct 12, 2020

Melatonin ingestion after exhaustive late-evening exercise attenuate muscle damage, oxidative stress, and inflammation.Dec 01, 2019

Melatonin is an effective and safe alternative for the treatment of chronic tension-type headache.Nov 30, 2020

Melatonin is associated with a statistically significant decrease in tinnitus intensity and improved sleep quality in patients with chronic tinnitus.Jul 01, 2011

Melatonin levels are associated with hypothalamic gray matter volume loss and disease severity in PD patients. Mar 11, 2016

Melatonin may be a safe treatment for patients with idiopathic tinnitus. Article 1Feb 01, 2006

Melatonin may be a safe treatment for patients with idiopathic tinnitus. Article 2Mar 01, 1998

Melatonin may be effective in treating refractory idiopathic thrombocytopenic purpura.Dec 01, 2001

Melatonin may be effective in treating severe bleeding associated with refractory idiopathic thrombocytopenic purpura. Mar 01, 2003

Melatonin significantly improvement impaired sleep maintenance in children with Autism. Jan 01, 2008

Melatonin significantly improves insomnia in patients aged 55 years or older. Jan 01, 2000

Melatonin significantly reduced the risk of depressive symptoms in women with breast cancer during a three-month period after surgery.May 31, 2014

Melatonin supplementation in diabetic diabetic hemodialysis patients had beneficial results.Oct 05, 2019

Melatonin supplementation is useful in treating H. pylori-associated dyspepsia.Nov 25, 2020

Melatonin treatment is associated with significant nocturia response rate.Mar 01, 2004

Melatonin was superior to amitriptyline in the percentage of patients with a greater than 50% reduction in migraine frequency.May 09, 2016

Melatonin, quercetin and NAC are beneficial in reducing oxidative stress in the patients with Grave's Disease. Sep 01, 2005

Mobile phone exposure may affect melatonin onset time.Feb 01, 2006

one-year treatment with melatonin increased bone mineral density at femoral neck in a dose-dependent manner, while high dose melatonin increased vBMD in the spine.Jun 02, 2015

Overnight melatonin secretion was significantly higher after using a blue-light shield on self-luminous devices. Dec 31, 2015

Patients treated with melatonin-containing emulsion experienced significantly reduced radiation dermatitis.Feb 29, 2016

Patients treated with melatonin-containing emulsion experienced significantly reduced radiation dermatitis.Feb 29, 2016

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View the Evidence:
648 Abstracts with Melatonin Research