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21 Diseases Researched for Natto
NameACCKFocus
Osteoporosis550Locked
Thrombosis525Locked
Hyperlipidemia220Locked
Hypertension220Locked
Atherosclerosis110Locked
Clotting110Locked
Deep Vein Thrombosis110Locked
Osteopenia110Locked
Rhinosinusitis110Locked
Thromboembolism 110Locked
Arteriosclerosis26Locked
Intima Media Thickening 26Locked
Alzheimer's Disease12Locked
Cardiovascular Diseases22Locked
Nerve Injuries12Locked
Peripheral Nerve Diseases12Locked
Sciatica12Locked
Aging Skin11Locked
Bone Fractures11Locked
Brain Ischemia11Locked
Coronavirus Infection11Locked
18 Pharmacological Actions Researched for Natto
NameACCKFocus
Anti-atherogenic110Locked
Anticholesteremic Agents110Locked
Antihypertensive Agents110Locked
Hypolipidemic110Locked
Hypotensive110Locked
Platelet Aggregation Inhibitors110Locked
Secretagogue110Locked
Fibrinolytic Agents25Locked
Neuroprotective Agents23Locked
Anti-Platelet12Locked
Cardioprotective22Locked
Interleukin-6 Downregulation12Locked
Neuritogenic12Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor12Locked
Anti-thrombotic11Locked
Antiviral Agents11Locked
Malondialdehyde Down-regulation11Locked
Superoxide Dismutase Up-regulation11Locked
Related Topics

Natto is a Sub of the following Topics

View the Evidence:
31 Abstracts with Natto Research

[+]

A combination of pine bark extract and nattokinase prevents venous thrombosis in long-haul flights.Sep 01, 2003

Pubmed Data : Angiology. 2003 Sep-Oct;54(5):531-9. PMID: 14565628
Article Published Date : Sep 01, 2003
Study Type : Human Study
Additional Links
Substances : Flavonoids, Nattokinase
Diseases : Deep Vein Thrombosis, Thromboembolism , Thrombosis
Pharmacological Actions : Platelet Aggregation Inhibitors
[+]

AGM possibly improves insulin sensitivity and β-cell function and reduces liver damage and inflammation in prediabetic adults.Jul 04, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2021 Jul 5 ;10(7). Epub 2021 Jul 5. PMID: 34359426
Article Published Date : Jul 04, 2021
Study Type : Human Study
Additional Links
Substances : Chokeberry, Ginseng, Nattokinase, Shiitake Mushroom
Diseases : Prediabetes
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
[+]

Consumption of nattokinase was associated with a reduction in both systolic and diastolic blood pressure.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Blood Press Control. 2016 ;9:95-104. Epub 2016 Oct 13. PMID: 27785095
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Substances : Nattokinase
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
[+]

Effective management of atherosclerosis progress and hyperlipidemia with nattokinase.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cardiovasc Med. 2022 ;9:964977. Epub 2022 Aug 22. PMID: 36072877
Article Published Date : Dec 31, 2021
Study Type : Human Study
Additional Links
Substances : Nattokinase
Diseases : Atherosclerosis, Cardiovascular Diseases, Hyperlipidemia
Pharmacological Actions : Cardioprotective
[+]

Intake of fermented soybean (natto) increases circulating vitamin K2 and osteocalcin (a marker for bone formation) in normal individuals. Jan 01, 2000

Pubmed Data : J Bone Miner Metab. 2000;18(4):216-22. PMID: 10874601
Article Published Date : Jan 01, 2000
Study Type : Human Study
Additional Links
Substances : Natto , Vitamin K
Diseases : Osteoporosis
Pharmacological Actions : Secretagogue
[+]

Natto, a rich source of vitamin K2, promotes bone formation in premenopausal women. Apr 01, 2004

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2004 Apr;50(2):114-20. PMID: 15242015
Article Published Date : Apr 01, 2004
Study Type : Human Study
Additional Links
Substances : Natto , Vitamin K
Diseases : Osteoporosis
[+]

Nattokinase combined with red yeast rice, but not nattokinase alone, has potent effects on blood lipids in human subjects with hyperlipidemia.Jan 01, 2009

Pubmed Data : Asia Pac J Clin Nutr. 2009;18(3):310-7. PMID: 19786378
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Substances : Nattokinase, Red Yeast Rice
Diseases : Hyperlipidemia
Pharmacological Actions : Anticholesteremic Agents
Additional Keywords : Natural Substance Synergy
[+]

Nattokinase decreases plasma levels of fibrinogen, factor VII and factor VIII in human subjects. Mar 01, 2009

Pubmed Data : Nutr Res. 2009 Mar;29(3):190-6. PMID: 19358933
Article Published Date : Mar 01, 2009
Study Type : Human Study
Additional Links
Substances : Nattokinase
Diseases : Clotting, Thrombosis
[+]

Nattokinase effectively shrinks the nasal polyp tissue through fibrin degradation.Sep 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Allergol Int. 2017 Oct ;66(4):594-602. Epub 2017 Apr 4. PMID: 28389065
Article Published Date : Sep 30, 2017
Study Type : Human Study
Additional Links
Substances : Nattokinase
Diseases : Rhinosinusitis
[+]

Nattokinase lowers systolic and diastolic blood pressure in human subjects. Jun 01, 2010

Pubmed Data : J Cell Physiol. 2010 Jun;223(3):771-8. PMID: 18971533
Article Published Date : Jun 01, 2010
Study Type : Human Study
Additional Links
Substances : Nattokinase
Diseases : Hypertension
Pharmacological Actions : Hypotensive
[+]

Nattokinase supplementation is an effective way to manage the progression of atherosclerosis and potentially may be a better alternative to statins.Jul 10, 2017

Pubmed Data : Zhonghua Yi Xue Za Zhi. 2017 Jul 11 ;97(26):2038-2042. PMID: 28763875
Article Published Date : Jul 10, 2017
Study Type : Human Study
Additional Links
Substances : Nattokinase
Diseases : Atherosclerosis, Hyperlipidemia
Pharmacological Actions : Anti-atherogenic, Hypolipidemic
[+]

Prolonged intake of fermented soybean (natto) diets containing vitamin K2 (menaquinone-7) prevents bone loss in ovariectomized rats.Jan 01, 2000

Pubmed Data : J Bone Miner Metab. 2000;18(2):71-6. PMID: 10701161
Article Published Date : Jan 01, 2000
Study Type : Human Study
Additional Links
Substances : Natto , Vitamin K
Diseases : Osteopenia, Osteoporosis
[+]

The consumption of vitamin K2 rich fermented soybean food products may contribute to the relatively lower fracture risk of Japanese women. Apr 01, 2001

Pubmed Data : Nutrition. 2001 Apr;17(4):315-21. PMID: 11369171
Article Published Date : Apr 01, 2001
Study Type : Human Study
Additional Links
Substances : Fermented Foods and Beverages, Natto , Soy, Vitamin K, Vitamin K2: Menaquinone-7
Diseases : Osteoporosis
Additional Keywords : Risk Reduction
[+]

Usual dietary intake of fermented soybeans (Natto) is associated with bone mineral density in premenopausal women.Jun 01, 2002

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2002 Jun;48(3):207-15. PMID: 12350079
Article Published Date : Jun 01, 2002
Study Type : Human Study
Additional Links
Substances : Natto
Diseases : Osteoporosis
[+]

A fermented soy product, Natto, contributes to the regeneration of nerve function following sciatic nerve crush injury. Aug 23, 2009

Pubmed Data : J Biomed Sci. 2009 Aug 23;16(1):75. PMID: 19698158
Article Published Date : Aug 23, 2009
Study Type : Animal Study
Additional Links
Substances : Fermented Foods and Beverages, Natto
Diseases : Nerve Injuries
Pharmacological Actions : Neuritogenic
Additional Keywords : Nerve Regeneration
[+]

Dietary supplementation of fermented soybean, natto, suppresses intimal thickening after endothelial injury in rat femoral arteryJul 25, 2003

Pubmed Data : Life Sci. 2003 Jul 25;73(10):1289-98. PMID: 12850244
Article Published Date : Jul 25, 2003
Study Type : Animal Study
Additional Links
Substances : Nattokinase, Soy
Diseases : Arteriosclerosis, Intima Media Thickening
[+]

Dietary supplementation with fermented soybeans suppresses intimal thickening.Mar 01, 2003

Pubmed Data : Nutrition. 2003 Mar;19(3):261-4. PMID: 12620531
Article Published Date : Mar 01, 2003
Study Type : Animal Study
Additional Links
Substances : Natto , Nattokinase
Diseases : Arteriosclerosis, Intima Media Thickening
Pharmacological Actions : Fibrinolytic Agents
Additional Keywords : Thrombolytic
[+]

Nattokinase attenuates bisphenol A or gamma irradiation-mediated hepatic and neural toxicity.May 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Sci Pollut Res Int. 2022 Jun 1. Epub 2022 Jun 1. PMID: 35648353
Article Published Date : May 31, 2022
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Bisphenol Toxicity
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Bisphenol A
[+]

Nattokinase attenuates retinal neovascularization. May 02, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Invest Ophthalmol Vis Sci. 2021 May 3 ;62(6):25. PMID: 34036312
Article Published Date : May 02, 2021
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Corneal Neovascularization, Retinal Diseases
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Nattokinase could be a good candidate without adverse effects for the improvement of blood flow.Nov 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lab Anim Res. 2013 Dec ;29(4):221-5. Epub 2013 Dec 20. PMID: 24396387
Article Published Date : Nov 30, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Nattokinase
Diseases : Thrombosis
[+]

Nattokinase could modulate certain factors that are associated with Alzheimer's disease pathophysiology.Jun 30, 2013

Pubmed Data : Hum Exp Toxicol. 2013 Jul ;32(7):721-35. PMID: 23821590
Article Published Date : Jun 30, 2013
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Alzheimer's Disease
Pharmacological Actions : Interleukin-6 Downregulation, Neuroprotective Agents
[+]

The fermented soy product natto improves neurobehavioral deficits after sciatic nerve injury in rats. May 01, 2007

Pubmed Data : Phytother Res. 2007 May;21(5):401-5. PMID: 19309538
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : Fermented Foods and Beverages, Natto
Diseases : Peripheral Nerve Diseases, Sciatica
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

A fermented soybean (natto) and astragalus combination stimulates hyaluronic acid synthesis in human skin cells. Jul 17, 2009

Pubmed Data : J Ethnopharmacol. 2009 Jul 17. PMID: 19619633
Article Published Date : Jul 17, 2009
Study Type : In Vitro Study
Additional Links
Substances : Astragalus, Fermented Foods and Beverages, Natto , Soy
Diseases : Aging Skin
[+]

Mechanisms of Nattokinase in protection of cerebral ischemia.Dec 14, 2014

Pubmed Data : Eur J Pharmacol. 2014 Dec 15 ;745:144-51. Epub 2014 Oct 27. PMID: 25446567
Article Published Date : Dec 14, 2014
Study Type : In Vitro Study
Additional Links
Substances : Nattokinase
Diseases : Brain Ischemia
Pharmacological Actions : Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

Natto contains a protein with both antithrombotic and fibrinolytic effects. Nov 01, 2005

Pubmed Data : J Pharmacol Sci. 2005 Nov;99(3):247-51. Epub 2005 Oct 27. PMID: 16258229
Article Published Date : Nov 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Fermented Foods and Beverages, Natto , Soy
Diseases : Thrombosis
Pharmacological Actions : Anti-thrombotic, Fibrinolytic Agents
[+]

Natto extract, a Japanese fermented soybean food, directly inhibits viral infections including SARS-CoV-2 in vitro.Jul 12, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochem Biophys Res Commun. 2021 Jul 13 ;570:21-25. Epub 2021 Jul 13. PMID: 34271432
Article Published Date : Jul 12, 2021
Study Type : In Vitro Study
Additional Links
Substances : Natto
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Nattokinase exhibits potential for the inhibition of SARS-CoV-2 infection via S protein degradation.Aug 23, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2022 Aug 24 ;27(17). Epub 2022 Aug 24. PMID: 36080170
Article Published Date : Aug 23, 2022
Study Type : In Vitro Study
Additional Links
Substances : Nattokinase
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
Additional Keywords : SARS-CoV-2 Spike Protein
[+]

Nattokinase reduces red blood cell aggregation.Jan 01, 2006

Pubmed Data : Clin Hemorheol Microcirc. 2006;35(1-2):139-42. PMID: 16899918
Article Published Date : Jan 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Natto , Nattokinase
Diseases : Thrombosis
Pharmacological Actions : Anti-Platelet
[+]

The intake of natto, an excellent source of vitamin K2, may reduce bone fracture risk. Sep 01, 2009

Pubmed Data : Clin Calcium. 2009 Sep;19(9):1362-9. PMID: 19721210
Article Published Date : Sep 01, 2009
Study Type : Review
Additional Links
Substances : Natto , Vitamin K2, Vitamin K2: Menaquinone-7
Diseases : Bone Fractures
[+]

These results support the safety of nattokinase as an agent for cardiovascular diseases prevention.Mar 31, 2019

Pubmed Data : Regul Toxicol Pharmacol. 2019 Apr ;103:205-209. Epub 2019 Feb 8. PMID: 30742876
Article Published Date : Mar 31, 2019
Study Type : Review
Additional Links
Substances : Nattokinase
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective
[+]

This review covers the history, benefit, safety, and production of nattokinase.Feb 27, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Feb 28 ;18(3). Epub 2017 Feb 28. PMID: 28264497
Article Published Date : Feb 27, 2017
Study Type : Review
Additional Links
Substances : Nattokinase
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective

Copyright: photodee / 123RF Stock Photo

Natto Related Articles

Nattokinase for Nasal Polyps and as a Mucolytic
Written by Dr. Michael Murray
Chronic nasal and sinus inflammation or chronic rhinosinusitis (CRS) is is one of the most common chronic diseases in adults. It is characterized by persistent symptomatic inflammation of the nasal mucosa and sinuses. A new study indicates that nattokinase, an enzyme from Nattō, a traditional fermented food from Japan can produce incredibly powerful effects in improving this condition. The breakthrough is that CRS does not tend to respond to conventional drugs

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