Nattokinase

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31 Diseases Researched for Nattokinase
NameACCKFocus
Cardiovascular Diseases636Locked
Hyperlipidemia330Locked
Thrombosis525Locked
Atherosclerosis322Locked
Hypertension220Locked
Clotting110Locked
Deep Vein Thrombosis110Locked
Prediabetes110Locked
Rhinosinusitis110Locked
Thromboembolism 110Locked
Alzheimer's Disease36Locked
Arteriosclerosis24Locked
Intima Media Thickening 24Locked
Advanced Glycation End products (AGE)12Locked
Aluminum Toxicity 12Locked
Bisphenol Toxicity12Locked
Brain Inflammation 12Locked
Breast Cancer: Triple Negative 12Locked
Cancers: All12Locked
Colitis12Locked
Corneal Neovascularization12Locked
Diabetes Mellitus: Type 212Locked
Diabetic Retinopathy12Locked
Inflammation12Locked
Myocardial Infarction12Locked
Oral Mucositis12Locked
Retinal Diseases12Locked
Stroke12Locked
Brain Ischemia11Locked
Coronavirus Infection11Locked
Stroke: Ischemic11Locked
27 Pharmacological Actions Researched for Nattokinase
NameACCKFocus
Cardioprotective636Locked
Anti-Inflammatory Agents721Locked
Anti-atherogenic110Locked
Anticholesteremic Agents110Locked
Antihypertensive Agents110Locked
Hepatoprotective110Locked
Hypolipidemic110Locked
Hypotensive110Locked
Neuroprotective Agents610Locked
Platelet Aggregation Inhibitors110Locked
Antioxidants47Locked
Heme oxygenase-1 up-regulation24Locked
Interleukin-6 Downregulation24Locked
Nrf2 activation24Locked
Analgesics12Locked
Anti-Apoptotic12Locked
Anti-Glycation Agents12Locked
Brain-derived neurotrophic factor modulator12Locked
Chemosensitizer12Locked
Fibrinolytic Agents12Locked
Neurogenesis12Locked
Radiosensitizer12Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor12Locked
Anti-Platelet11Locked
Antiviral Agents11Locked
Malondialdehyde Down-regulation11Locked
Superoxide Dismutase Up-regulation11Locked
Related Topics

Nattokinase is a Sub of the following Topics

View the Evidence:
34 Abstracts with Nattokinase Research

[+]

Nattokinase supplementation and cardiovascular risk factors.Jul 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Rev Cardiovasc Med. 2023 Aug ;24(8):234. Epub 2023 Aug 15. PMID: 39076715
Article Published Date : Jul 31, 2023
Study Type : Meta Analysis, Review
Additional Links
Substances : Nattokinase
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective
[+]

A combination of pine bark extract and nattokinase prevents venous thrombosis in long-haul flights.Sep 01, 2003

Pubmed Data : Angiology. 2003 Sep-Oct;54(5):531-9. PMID: 14565628
Article Published Date : Sep 01, 2003
Study Type : Human Study
Additional Links
Substances : Flavonoids, Nattokinase
Diseases : Deep Vein Thrombosis, Thromboembolism , Thrombosis
Pharmacological Actions : Platelet Aggregation Inhibitors
[+]

AGM possibly improves insulin sensitivity and β-cell function and reduces liver damage and inflammation in prediabetic adults.Jul 04, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2021 Jul 5 ;10(7). Epub 2021 Jul 5. PMID: 34359426
Article Published Date : Jul 04, 2021
Study Type : Human Study
Additional Links
Substances : Chokeberry, Ginseng, Nattokinase, Shiitake Mushroom
Diseases : Prediabetes
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
[+]

Consumption of nattokinase was associated with a reduction in both systolic and diastolic blood pressure.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Blood Press Control. 2016 ;9:95-104. Epub 2016 Oct 13. PMID: 27785095
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Substances : Nattokinase
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
[+]

Effective management of atherosclerosis progress and hyperlipidemia with nattokinase.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cardiovasc Med. 2022 ;9:964977. Epub 2022 Aug 22. PMID: 36072877
Article Published Date : Dec 31, 2021
Study Type : Human Study
Additional Links
Substances : Nattokinase
Diseases : Atherosclerosis, Cardiovascular Diseases, Hyperlipidemia
Pharmacological Actions : Cardioprotective
[+]

Nattokinase combined with red yeast rice, but not nattokinase alone, has potent effects on blood lipids in human subjects with hyperlipidemia.Jan 01, 2009

Pubmed Data : Asia Pac J Clin Nutr. 2009;18(3):310-7. PMID: 19786378
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Substances : Nattokinase, Red Yeast Rice
Diseases : Hyperlipidemia
Pharmacological Actions : Anticholesteremic Agents
Additional Keywords : Natural Substance Synergy
[+]

Nattokinase decreases plasma levels of fibrinogen, factor VII and factor VIII in human subjects. Mar 01, 2009

Pubmed Data : Nutr Res. 2009 Mar;29(3):190-6. PMID: 19358933
Article Published Date : Mar 01, 2009
Study Type : Human Study
Additional Links
Substances : Nattokinase
Diseases : Clotting, Thrombosis
[+]

Nattokinase effectively shrinks the nasal polyp tissue through fibrin degradation.Sep 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Allergol Int. 2017 Oct ;66(4):594-602. Epub 2017 Apr 4. PMID: 28389065
Article Published Date : Sep 30, 2017
Study Type : Human Study
Additional Links
Substances : Nattokinase
Diseases : Rhinosinusitis
[+]

Nattokinase lowers systolic and diastolic blood pressure in human subjects. Jun 01, 2010

Pubmed Data : J Cell Physiol. 2010 Jun;223(3):771-8. PMID: 18971533
Article Published Date : Jun 01, 2010
Study Type : Human Study
Additional Links
Substances : Nattokinase
Diseases : Hypertension
Pharmacological Actions : Hypotensive
[+]

Nattokinase supplementation is an effective way to manage the progression of atherosclerosis and potentially may be a better alternative to statins.Jul 10, 2017

Pubmed Data : Zhonghua Yi Xue Za Zhi. 2017 Jul 11 ;97(26):2038-2042. PMID: 28763875
Article Published Date : Jul 10, 2017
Study Type : Human Study
Additional Links
Substances : Nattokinase
Diseases : Atherosclerosis, Hyperlipidemia
Pharmacological Actions : Anti-atherogenic, Hypolipidemic
[+]

Dietary supplementation of fermented soybean, natto, suppresses intimal thickening after endothelial injury in rat femoral arteryJul 25, 2003

Pubmed Data : Life Sci. 2003 Jul 25;73(10):1289-98. PMID: 12850244
Article Published Date : Jul 25, 2003
Study Type : Animal Study
Additional Links
Substances : Nattokinase, Soy
Diseases : Arteriosclerosis, Intima Media Thickening
[+]

Dietary supplementation with fermented soybeans suppresses intimal thickening.Mar 01, 2003

Pubmed Data : Nutrition. 2003 Mar;19(3):261-4. PMID: 12620531
Article Published Date : Mar 01, 2003
Study Type : Animal Study
Additional Links
Substances : Natto , Nattokinase
Diseases : Arteriosclerosis, Intima Media Thickening
Pharmacological Actions : Fibrinolytic Agents
Additional Keywords : Thrombolytic
[+]

Effect of nattokinase in D-galactose- and aluminum chloride-induced Alzheimer's disease.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : In Vivo. 2024 ;38(6):2672-2679. PMID: 39477413
Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Aluminum Toxicity , Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Aluminum Chloride
[+]

Effect of nattokinase on the pathological conditions in streptozotocin induced diabetic rats.Apr 14, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2024 Apr 15 ;10(7):e28835. Epub 2024 Mar 27. PMID: 38586318
Article Published Date : Apr 14, 2024
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Advanced Glycation End products (AGE), Diabetes Mellitus: Type 2
Pharmacological Actions : Anti-Glycation Agents
[+]

Nattokinase attenuates bisphenol A or gamma irradiation-mediated hepatic and neural toxicity.May 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Sci Pollut Res Int. 2022 Jun 1. Epub 2022 Jun 1. PMID: 35648353
Article Published Date : May 31, 2022
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Bisphenol Toxicity
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Bisphenol A
[+]

Nattokinase attenuates endothelial inflammation through the activation of SRF and THBS1.Apr 30, 2024

Pubmed Data : Int J Biol Macromol. 2024 May ;268(Pt 2):131779. Epub 2024 Apr 27. PMID: 38679250
Article Published Date : Apr 30, 2024
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Atherosclerosis, Cardiovascular Diseases, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Nattokinase attenuates retinal neovascularization. May 02, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Invest Ophthalmol Vis Sci. 2021 May 3 ;62(6):25. PMID: 34036312
Article Published Date : May 02, 2021
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Corneal Neovascularization, Retinal Diseases
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Nattokinase could be a good candidate without adverse effects for the improvement of blood flow.Nov 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lab Anim Res. 2013 Dec ;29(4):221-5. Epub 2013 Dec 20. PMID: 24396387
Article Published Date : Nov 30, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Nattokinase
Diseases : Thrombosis
[+]

Nattokinase could modulate certain factors that are associated with Alzheimer's disease pathophysiology.Jun 30, 2013

Pubmed Data : Hum Exp Toxicol. 2013 Jul ;32(7):721-35. PMID: 23821590
Article Published Date : Jun 30, 2013
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Alzheimer's Disease
Pharmacological Actions : Interleukin-6 Downregulation, Neuroprotective Agents
[+]

Nattokinase crude extract enhances oral mucositis healing.Oct 29, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Oral Health. 2021 Oct 30 ;21(1):555. Epub 2021 Oct 30. PMID: 34717590
Article Published Date : Oct 29, 2021
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Oral Mucositis
Pharmacological Actions : Analgesics
[+]

Nattokinase encapsulated nanomedicine for targeted thrombolysis.Dec 31, 2023

Pubmed Data : Mol Pharm. 2024 Jan 1 ;21(1):283-302. Epub 2023 Dec 21. PMID: 38126777
Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Thrombosis
[+]

Nattokinase enhances the preventive effects of Escherichia coli Nissle 1917 on dextran sulfate sodium-induced colitis.Nov 08, 2022

Pubmed Data : World J Microbiol Biotechnol. 2022 Nov 9 ;39(1):8. Epub 2022 Nov 9. PMID: 36350434
Article Published Date : Nov 08, 2022
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Nattokinase prevents β-amyloid peptide (Aβ1-42) induced neuropsychiatric complications, neuroinflammation and BDNF signalling disruption.Aug 04, 2023

Pubmed Data : Eur J Pharmacol. 2023 Aug 5 ;952:175821. Epub 2023 May 30. PMID: 37263404
Article Published Date : Aug 04, 2023
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Brain-derived neurotrophic factor modulator, Neuroprotective Agents
[+]

Nattokinase promotes post-stroke neurogenesis and cognition recovery.Aug 01, 2023

Pubmed Data : J Agric Food Chem. 2023 Aug 2 ;71(30):11418-11428. Epub 2023 Jul 19. PMID: 37466380
Article Published Date : Aug 01, 2023
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Stroke
Pharmacological Actions : Neurogenesis, Neuroprotective Agents
[+]

Nattokinase-loaded nanozymes can be a promising approach for treating acute myocardial infarction.Dec 14, 2024

Pubmed Data : Adv Healthc Mater. 2024 Dec 15:e2402763. Epub 2024 Dec 15. PMID: 39676430
Article Published Date : Dec 14, 2024
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Myocardial Infarction
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Nattokinase-mediated regulation of tumor physical microenvironment to enhance chemotherapy, radiotherapy, and CAR-T therapy of solid tumor.Apr 24, 2023

Pubmed Data : ACS Nano. 2023 Apr 25 ;17(8):7475-7486. Epub 2023 Apr 14. PMID: 37057972
Article Published Date : Apr 24, 2023
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Breast Cancer: Triple Negative , Cancers: All
Pharmacological Actions : Chemosensitizer, Radiosensitizer
[+]

Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy.Sep 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Diabetes. 2023 Oct ;15(10):866-880. Epub 2023 Jul 4. PMID: 37403338
Article Published Date : Sep 30, 2023
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Brain Inflammation , Diabetic Retinopathy
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Comparative cardioprotective effectiveness: NOACs vs. nattokinase-bridging basic research to clinical findings.Aug 06, 2024

Pubmed Data : Biomolecules. 2024 Aug 7 ;14(8). Epub 2024 Aug 7. PMID: 39199344
Article Published Date : Aug 06, 2024
Study Type : Review
Additional Links
Substances : Nattokinase
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective
[+]

Mechanisms of Nattokinase in protection of cerebral ischemia.Dec 14, 2014

Pubmed Data : Eur J Pharmacol. 2014 Dec 15 ;745:144-51. Epub 2014 Oct 27. PMID: 25446567
Article Published Date : Dec 14, 2014
Study Type : In Vitro Study
Additional Links
Substances : Nattokinase
Diseases : Brain Ischemia
Pharmacological Actions : Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

Nattokinase exhibits potential for the inhibition of SARS-CoV-2 infection via S protein degradation.Aug 23, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2022 Aug 24 ;27(17). Epub 2022 Aug 24. PMID: 36080170
Article Published Date : Aug 23, 2022
Study Type : In Vitro Study
Additional Links
Substances : Nattokinase
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
Additional Keywords : SARS-CoV-2 Spike Protein
[+]

Nattokinase reduces red blood cell aggregation.Jan 01, 2006

Pubmed Data : Clin Hemorheol Microcirc. 2006;35(1-2):139-42. PMID: 16899918
Article Published Date : Jan 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Natto , Nattokinase
Diseases : Thrombosis
Pharmacological Actions : Anti-Platelet
[+]

These data demonstrated that nattokinase had multifaceted neuroprotection in ischemic brain injury.Sep 04, 2024

Pubmed Data : Antioxid Redox Signal. 2024 Sep 5. Epub 2024 Sep 5. PMID: 39135387
Article Published Date : Sep 04, 2024
Study Type : In Vitro Study
Additional Links
Substances : Nattokinase
Diseases : Stroke: Ischemic
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

These results support the safety of nattokinase as an agent for cardiovascular diseases prevention.Mar 31, 2019

Pubmed Data : Regul Toxicol Pharmacol. 2019 Apr ;103:205-209. Epub 2019 Feb 8. PMID: 30742876
Article Published Date : Mar 31, 2019
Study Type : Review
Additional Links
Substances : Nattokinase
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective
[+]

This review covers the history, benefit, safety, and production of nattokinase.Feb 27, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Feb 28 ;18(3). Epub 2017 Feb 28. PMID: 28264497
Article Published Date : Feb 27, 2017
Study Type : Review
Additional Links
Substances : Nattokinase
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective

Copyright: photodee / 123RF Stock Photo

Nattokinase Related Articles

Nattokinase for Nasal Polyps and as a Mucolytic
Written by Dr. Michael Murray
Chronic nasal and sinus inflammation or chronic rhinosinusitis (CRS) is is one of the most common chronic diseases in adults. It is characterized by persistent symptomatic inflammation of the nasal mucosa and sinuses. A new study indicates that nattokinase, an enzyme from Nattō, a traditional fermented food from Japan can produce incredibly powerful effects in improving this condition. The breakthrough is that CRS does not tend to respond to conventional drugs
Alarming New Poll Reveals Millions Taking Aspirin Despite Risks, Natural Alternatives Exist
Written by GreenMedInfo Research Group
A concerning new poll shows that over half of older adults taking daily aspirin have no history of heart disease and may be putting themselves at risk of potentially life-threatening bleeding, while safer natural alternatives exist

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