Neem

Name	AC	CK
HIV Infections	4	22
Malaria	4	15
Coronavirus Infection	5	14
Head and Neck Cancer	3	14
Metabolic Syndrome X	2	11
Scabies	2	11
AIDS	1	10
Chemotherapy and Radiation Toxicity	1	10
Chemotherapy-Induced Toxicity: Cisplatin	1	10
Dysuria	1	10
Endothelial Dysfunction	1	10
Gastroduodenal Ulcer	1	10
Gastroesophageal Reflux	1	10
Gingivitis	1	10
Head Lice	1	10
Insulin Resistance	1	10
Peptic Ulcer	1	10
Vaginal Discharge: Abnormal	1	10
Breast Cancer	8	8
Hyperglycemia	4	8
Diabetes Mellitus: Type 2	4	7
Inflammation	5	7
Prostate Cancer	6	7
Diabetes Mellitus: Type 1	3	6
Diabetic Nephropathy	3	6
Liver Cancer	5	6
Oral Cancer	5	6
Cancers: All	5	5
Enterococcus Infections	5	5
Leukemia: Chronic Lymphocytic Leukemia (CLL)	1	5
Staphylococcus aureus infection	5	5
Arthritis	2	4
Brain Inflammation	2	4
Cervical Cancer	4	4
Colon Cancer	3	4
Kidney Fibrosis	2	4
Lipopolysaccharide-Induced Toxicity	3	4
Lung Cancer	4	4
Oxidative Stress	2	4
Pancreatic Cancer	4	4
Breast Cancer: Triple Negative	3	3
Candida Albicans	3	3
Escherichia coli Infections	3	3
Lymphoma	2	3
Pseudomonas aeruginosa	3	3
Psoriasis	2	3
Radiotherapy	1	3
Rheumatoid Arthritis	2	3
Wound Healing	2	3
Acute T cell Leukemias	1	2
Alzheimer's Disease	2	2
Anxiety	1	2
Anxiety Disorders	1	2
Arsenic Poisoning	1	2
Benzo[a]pyrene-induced Toxicity	1	2
Breast Cancer: Chemically-Induced	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	2	2
Cholera	1	2
Chronic Obstructive Pulmonary Disease	1	2
Colitis	1	2
Colorectal Cancer	2	2
Dengue	2	2
Dental Caries	2	2
Depression	1	2
Diabetes: Cognitive Dysfunction	1	2
Diabetic Retinopathy	1	2
Diarrhea	1	2
Drug Toxicity: Methotrexate	1	2
Duodenal Ulcer	1	2
Dysbiosis	1	2
Dyslipidemias	1	2
Fluoride Toxicity	1	2
Gestational Diabetes	1	2
Gram-Positive Bacterial Infections	2	2
Hepatitis	1	2
Hepatitis: Autoimmune	1	2
Hypertension	1	2
Leukopenia: Chemotherapy Induced	1	2
Multiple Sclerosis	1	2
Nerve Injuries	1	2
Petroleum Exposure And Toxicity	1	2
Salmonella Infections	2	2
Sciatic Nerve Crush Injury	1	2
Smoking	1	2
Squamous cell carcinoma	2	2
Staphylococcus aureus: Methicillin-resistant (MRSA)	2	2
Steptococcus Mutans Infections	2	2
Animal Diseases: Infectious	1	1
Asthma	1	1
Bladder Cancer	1	1
Cancer Metastasis	1	1
Cancers: Drug Resistant	1	1
Cardiovascular Diseases	1	1
Chickenpox	1	1
Choriocarcinoma	1	1
Citrobacter Infection	1	1
Colic	1	1
Conjunctivitis	1	1
Coxsackievirus Infections	1	1
Dengue Fever	1	1
Denture Stomatitis	1	1
Dysmenorrhea	1	1
Fever	1	1
Foot and Mouth Disease	1	1
Gastric Cancer	1	1
Gastric Ulcer	1	1
Gout	1	1
Gram-Negative Bacterial Infections	1	1
HIV Drug-Induced Toxicity	1	1
HSV-1	1	1
Headache	1	1
Helicobacter Pylori Infection	1	1
Hypercholesterolemia	1	1
Infection: Antibiotic Resistant	1	1
Influenza	1	1
Influenza A	1	1
Insect Bites: Repellent	1	1
Klebsiella Infections	1	1
Muscle Soreness	1	1
Neuroblastoma	1	1
Pancreatitis	1	1
Pancreatitis: Chronic	1	1
Parkinson's Disease	1	1
Periodontal Diseases	1	1
Porphyromonas gingivalis	1	1
Pulmonary Fibrosis	1	1
Pulmonary Fibrosis: Bleomycin-Induced	1	1
Respiratory Infections	1	1
Rheumatism	1	1
Rhinovirus Infection	1	1
Staphylococcus epidermidis	1	1
Stomach Cancer	1	1
Streptococcus Infections	1	1

Name	AC	CK
Anti-Inflammatory Agents	28	43
Antioxidants	20	29
Apoptotic	20	25
Antiviral Agents	12	22
Antiproliferative	19	21
Antimicrobial	10	19
Hypoglycemic Agents	4	16
Immunomodulatory	6	16
Renoprotective	7	14
Tumor Necrosis Factor (TNF) Alpha Inhibitor	9	14
Chemoprotective Agents	4	13
NF-kappaB Inhibitor	10	13
Radioprotective	2	13
Anti-Bacterial Agents	12	12
Anti-HIV Agents	1	10
Antimalarials	1	10
Prophylactic Agents	1	10
Proton Pump Inhibitor	1	10
Anti-Apoptotic	6	9
Interleukin-1 beta downregulation	6	9
Interleukin-6 Downregulation	5	9
Neuroprotective Agents	6	9
Anti-metastatic	7	8
Antihypertensive Agents	4	7
Bcl-2 protein down-regulation	3	7
Hepatoprotective	4	7
Tumor Suppressor Protein p53 Upregulation	3	7
Alpha-amylase inhibitor	3	6
Anticarcinogenic Agents	4	6
Angiogenesis Inhibitors	4	5
Anti-Fibrotic	3	5
Chemopreventive	4	5
Hypolipidemic	3	5
Cardioprotective	3	4
Cell cycle arrest	4	4
Genoprotective	2	4
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	4
Alpha-glucosidase inhibitor	1	3
Chemotherapeutic	3	3
Transforming growth factor beta (TGF-β) inhibitor	2	3
Vascular Endothelial Growth Factor Inhibitors	2	3
Anti-Anxiety Agents	1	2
Antidepressive Agents	1	2
Antifungal Agents	2	2
Antimutagenic Agents	1	2
Antineoplastic Agents	2	2
Anxiolytic	1	2
Catalase Up-Regulation	1	2
Drug synergy	1	2
Gastrointestinal Agents	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	2
Insect Repellents	2	2
Interleukin-17 downregulation	1	2
Nrf2 activation	2	2
Pancreato Protective Agents	2	2
Phase II Detoxification Enzyme Inducer	1	2
Superoxide Dismutase Up-regulation	1	2
Anti-Ulcer Agents	1	1
Anticholesteremic Agents	1	1
Contraceptive Agents	1	1
Cyclin D1 Down-Regulation	1	1
Cytotoxic	1	1
Heme oxygenase-1 up-regulation	1	1
Interleukin-10 upregulation	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Nitric Oxide Inhibitor	1	1
P-glycoprotein Inhibitors	1	1
Protease Inhibitors	1	1
Quorum Sensing Inhibition	1	1
STAT3 Inhibitor	1	1
Wnt/β-catenin signaling pathway modulation	1	1

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A polyherbal formual containing Neem, Sapindus and Mentha citrata is superior to Betadine in treating lower abdominal pain, vaginal itching and dysuria in women with symptoms of abnormal vaginal discharge. Oct 01, 2009

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Pubmed Data : Asia Pac J Public Health. 2009 Oct;21(4):461-8. PMID: 19783561

Article Published Date : Oct 01, 2009

Study Type : Human Study

Additional Links

Substances : Mentha citrata, Neem, Sapindus

Diseases : Dysuria, Vaginal Discharge: Abnormal

Additional Keywords : Superiority of Natural Substances versus Drugs

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Aqueous Azadirachta indica extract attenuates insulin resistance to improve glycemic control and endothelial function.Oct 31, 2021

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Pubmed Data : J Med Food. 2021 Nov ;24(11):1135-1144. Epub 2021 Sep 28. PMID: 34582720

Article Published Date : Oct 31, 2021

Study Type : Human Study

Pharmacological Actions : Radioprotective

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Therapeutic role of Azadirachta indica leaves ethanolic extract against diabetic nephropathy in rats neonatally induced by streptozotocin.Nov 01, 2021

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Pubmed Data : Ultrastruct Pathol. 2021 Nov 2 ;45(6):391-406. Epub 2021 Oct 31. PMID: 34720017

Article Published Date : Feb 06, 2022

Study Type : Animal Study

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Substances : Neem

Diseases : Arthritis, Drug Toxicity: Methotrexate

Pharmacological Actions : Hepatoprotective, Renoprotective

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Combating effects of Azadirachta indica leaves extract on biochemical and neuropsychological decline observed in diabetes.Oct 31, 2022

Pubmed Data : West Indian Med J. 2010 Jun;59(3):245-8. PMID: 21291100

Article Published Date : Jun 01, 2010

Study Type : Animal Study

Additional Links

Substances : Neem

Diseases : Anxiety Disorders

Pharmacological Actions : Anxiolytic

Additional Keywords : Benzodiazepine Alternatives, Drug: Diazepam, Plant Extracts

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Pubmed Data : Mol Immunol. 2019 08 ;112:247-255. Epub 2019 Jun 12. PMID: 31202101

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Neem

Diseases : Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Renoprotective, Transforming growth factor beta (TGF-β) inhibitor

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Nimbolide attenuated the inflammation in the liver of autoimmune hepatitis's mice through regulation of HDAC3.Dec 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Phytomedicine. 2022 Jan ;94:153826. Epub 2021 Nov 1. PMID: 34775358

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Neem

Diseases : Prostate Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative

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Nimbolide protects the pregnant rats from GDM via alteration of inflammation, oxidative stress, and gut microbiota.Feb 24, 2022

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Pubmed Data : Environ Toxicol. 2022 Feb 25. Epub 2022 Feb 25. PMID: 35212444

Article Published Date : Feb 24, 2022

Study Type : Animal Study

Additional Links

Substances : Neem

Diseases : Gestational Diabetes

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

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Pubmed Data : J Basic Clin Physiol Pharmacol. 2017 Oct 5. Epub 2017 Oct 5. PMID: 28981443

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Pubmed Data : J Biomol Struct Dyn. 2020 May 28:1-17. Epub 2020 May 28. PMID: 32462988

Article Published Date : May 27, 2020

Study Type : In Vitro Study

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Substances : Neem

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

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A review of evolving herbal formulations in management of dengue fever.Aug 31, 2017

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Pubmed Data : J Ayurveda Integr Med. 2017 Jul - Sep;8(3):207-210. Epub 2017 Aug 18. PMID: 28823790

Article Published Date : Aug 31, 2017

Study Type : Review

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Substances : Neem, Papaya, Sea buckthorn

Diseases : Dengue Fever

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A review of the anticancer activity of Azadirachta indica in oral cancer. Mar 31, 2020

Article Published Date : Jul 29, 2018

Study Type : In Vitro Study

Additional Links

Substances : Neem

Diseases : Breast Cancer, Cervical Cancer, Liver Cancer, Lung Cancer

Pharmacological Actions : Antiproliferative

[+]

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Pubmed Data : Anticancer Res. 2019 Oct ;39(10):5473-5481. PMID: 31570441

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Pubmed Data : PLoS One. 2015 ;10(10):e0140113. Epub 2015 Oct 15. PMID: 26469405

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Neem

Diseases : Diabetes Mellitus: Type 2, Hyperglycemia

Pharmacological Actions : Alpha-amylase inhibitor, Hypoglycemic Agents

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Mango and neem tree extracts inhibit four organisms associated with dental caries. Oct 01, 2007

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Pubmed Data : Indian J Dent Res. 2007 Oct-Dec;18(4):148-51. PMID: 17938488

Article Published Date : Oct 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Mango , Neem

Diseases : Dental Caries, Steptococcus Mutans Infections

[+]

Methanolic neem stem bark extract induces cell cycle arrest, apoptosis and inhibits the migration of cervical cancer cells.Sep 09, 2022

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Pubmed Data : BMC Complement Med Ther. 2022 Sep 10 ;22(1):239. Epub 2022 Sep 10. PMID: 36088372

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Pubmed Data : Bioinformation. 2015 ;11(7):359-65. Epub 2015 Jul 31. PMID: 26339153

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Neem

Diseases : Influenza A

Pharmacological Actions : Antiviral Agents

Additional Keywords : Plant Extracts

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Neem seed oil inhibits the growth of human breast cancer cells.Jan 26, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Cancer Prev. 2017 08 27 ;18(8):2135-2140. Epub 2017 Aug 27. PMID: 28843234

Article Published Date : Jan 26, 2017

Study Type : In Vitro Study

Additional Links

Substances : Neem

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Plant Oils

[+]

Neem yielded antibacterial activity equivalent to 2% chlorhexidine or sodium hypochlorite against E. faecalis.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Bull Tokyo Dent Coll. 2017 ;58(2):103-109. PMID: 28724858

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Pubmed Data : Life Sci. 2021 Feb 1 ;266:118911. Epub 2020 Dec 16. PMID: 33333049

Article Published Date : Jan 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Neem

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, STAT3 Inhibitor

[+]

Nimbolide exhibits anticancer effect by reducing tumor size, tumor burden and by suppressing cell cycle progression in liver cancer.Dec 06, 2020

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Pubmed Data : Biomed Pharmacother. 2017 Jun ;90:935-946. Epub 2017 Apr 26. PMID: 28460429

Article Published Date : May 31, 2017

Study Type : Review

Additional Links

Substances : Astragalus, Chokeberry, Neem

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Cardioprotective, Chemoprotective Agents

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View the Evidence: 148 Abstracts with Neem Research

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A polyherbal formual containing Neem, Sapindus and Mentha citrata is superior to Betadine in treating lower abdominal pain, vaginal itching and dysuria in women with symptoms of abnormal vaginal discharge. Oct 01, 2009

Aqueous Azadirachta indica extract attenuates insulin resistance to improve glycemic control and endothelial function.Oct 31, 2021

Neem (A. indica) shows strong activity against six bacterial strains.Jan 01, 2007

Neem and Tumeric are a safe and effective topical treatment for scabies. Jan 01, 1992

Neem bark has therapeutic potential for controlling gastric hypersecretion and gastroesophageal and gastroduodenal uclcers. Oct 29, 2004

Neem has antimalarial and anti-HIV activity. Mar 01, 2009

Neem leaf extract safely increases CD4 cell levels in patients with HIV/AIDS. Jul 01, 2007

Neem mouthwash can be used as an alternative to chlorhexidine mouthwash.Jun 30, 2017

Neem oil and St. Johns Wort proved to be a safe and effective option in the management of acute skin toxicity in head and neck cancer patients.Jan 31, 2017

Neem seed extract shampoo is safe and effective in treating head lice infection in children. Jan 01, 2007

These results found that patients taking Neem capsules had a 55% less chance of COVID-19 infection.Apr 22, 2021

Neem leaf extract exhibits anti-leukemic properties in patient primary chronic lymphocytic leukemia cells.Feb 28, 2014

Molecular modeling and in vitro studies of gedunin a potent alpha-amylase inhibitor and alpha-glucosidase inhibitor.May 23, 2022

Gedunin modulates T lymphocyte responses and ameliorates allergic inflammation.Aug 31, 2012

Holistic care approach for the effective management of severe radiation dermatitis using neem and honey.Sep 30, 2020

Therapeutic role of Azadirachta indica leaves ethanolic extract against diabetic nephropathy in rats neonatally induced by streptozotocin.Nov 01, 2021

A polyphenol-rich fraction of Azadirachta indica could be used for the treatment of hypertension.Jun 18, 2018

A standardized extract of neem has neuroprotective effects in partial sciatic nerve injury.Dec 31, 2016

A water extract of neem exhibits gastroprotective effects against ulcers that is safe and effective.Jul 01, 2006

A. indica may play a significant role in the management of type-2 diabetes mellitusJun 30, 2015

Antioxidant and chemopreventive effects of Azadirachta indica on lead acetate-induced hepatotoxicity.Dec 30, 2022

Anxiolytic and antidepressant-like activities of aqueous extract of Azadirachta indica.Jan 31, 2022

Azadirachta indica ameliorates mouse hepatitis virus-induced neuroinflammatory demyelination.Dec 31, 2019

Azadirachta indica provides cardio protection by ameliorating oxidative stress in rat model of diabetic mellitus.Apr 30, 2016

Co-treatment of Nimbolide augmented the anti-arthritic effects of methotrexate while protecting against organ toxicities.Feb 06, 2022

Combating effects of Azadirachta indica leaves extract on biochemical and neuropsychological decline observed in diabetes.Oct 31, 2022

Effects of Azadirachta indica on neuropathic pain induced by chronic constriction injury to sciatic nerve of Wistar rat.Aug 31, 2022

Exploring the prophylactic potential of Azadirachta indica leaf extract against dyslipidemia.Feb 28, 2023

Extracts of Neem leaf were effective in inducing apoptosis in leukemia and colon cancer cells.Oct 31, 2015

Hematopoietic effects of Azadirachta indica methanolic extract in cyclophosphamide mediated myelosuppression.Aug 31, 2020

Improvement in serum amylase and glucose levels after administration of bisdemethoxycurcumin from Curcuma longa and limonoids from Azadirachta indica.Feb 25, 2021

Neem compare favorably to diazepam in reducing anxiety in mice without motor side effects. Jun 01, 2010

Neem extract exhibits chemopreventive effects on chemically-induced buccal pouch cancer in hamsters.Jun 01, 2005

Neem has an antibacterial, antisecretory and antihemorrhagic activity against Vibrio cholerae.May 22, 2007

Neem has anti-clastogenic activity against benzo(a)pyrene induced tumorigenesis.Jul 01, 2010

Neem leaf extract can be considered a potential candidate for protection against renal injury induced by malaria.Dec 31, 2014

Neem leaf extract decreased the expression of TNF-α and IL-6 in DSS-induced colitis.Nov 30, 2020

Neem leaf extract has potential for use in the treatment of chronic obstructive pulmonary disease.Nov 30, 2017

Nimbidiol ameliorates renal fibrosis and dysfunction in type-1 diabetes.Dec 14, 2022

Nimbidiol protects from renal injury by alleviating redox imbalance in diabetic mice.Dec 31, 2023

Nimbolide ameliorates the streptozotocin-induced diabetic retinopathy.Jul 31, 2021

Nimbolide ameliorates unilateral ureteral obstruction-induced renal fibrosis.Dec 31, 2018

Nimbolide attenuated the inflammation in the liver of autoimmune hepatitis's mice through regulation of HDAC3.Dec 31, 2021

Nimbolide attenuates complete Freund's adjuvant induced arthritis.Feb 28, 2023

Nimbolide has shown promising activity as an anti-psoriatic agent.Jun 30, 2021

Nimbolide inhibits 2D and 3D prostate cancer cells migration, affects microtubules and angiogenesis.Dec 31, 2021

Nimbolide protects the pregnant rats from GDM via alteration of inflammation, oxidative stress, and gut microbiota.Feb 24, 2022

Nimbolide represents a novel therapeutic drug for hepatocellular carcinoma treatment.Feb 28, 2022

Pretreatment with Neem diminishes leukopenia and enhances the effect of chemotherapy. Sep 01, 2006

Regular consumption of neem oil prevents chemically induced breast cancer.Dec 31, 2018

The present investigation provides novel insights into molecular mechanisms of nimbolide inhibited T cell lymphoma progression.Feb 23, 2022

The present study points out the protective effects of A. indica extract on pyramidal neurons in experimental cerebral malaria induced by P. berghei-infection in mice.Dec 31, 2012

The water extract of stem bark of neem possesses significant wound healing property.Jun 30, 2017

Thermally activated carbon prepared from neem and acacia arabica leaves were found to have fluoride removal properties.Feb 29, 2008

These results suggest that neem leaf extract has beta cell regenerating potential.May 04, 2015

This reports for the first time the genoprotective and antiapoptotic effect of Azadirachta indica against arsenic toxicity. May 03, 2018

This study shows the protective effect of neem on sodium fluoride induced hypertension and genotoxicity.Oct 04, 2017

Use of haematological signatures in conjunction with conventional biomarkers to assess Reno-protective effects of Gedunin in diabetic nephropathy.May 31, 2022

This review is an attempt to assess the antimicrobial efficacy of 10 plant extracts on dental caries and plaque microorganisms.Jun 30, 2015

A computational prediction of SARS-CoV-2 structural protein inhibitors from Azadirachta indica.May 27, 2020

A review of evolving herbal formulations in management of dengue fever.Aug 31, 2017

A review of the anticancer activity of Azadirachta indica in oral cancer. Mar 31, 2020

A. indica bark extract has a potent antibacterial property against S. aureus, E. faecalis, P. aeruginosa, and P. mirabilis.Dec 31, 2018

A. indica exhibited the in-vitro immunomodulatory potential to inhibit the continuum of SEB induced CD4+ T-cell activation/ exhaustion.Apr 08, 2021

A. indica leaf and C. roseus extracts alone or in combination with fluconazole and voriconazole could be promising for the management of candidiasis.Dec 31, 2021

All MRSA isolates were found susceptible to organic extracts of A. indica leaves.Jun 30, 2018

An extract of neem leaf and its bioactive liminoid, nimbolide, suppresses colon cancer in preclinical models.Dec 31, 2017

Anti-cancer activity of gedunin by induction of apoptosis in human gastric cancer AGS cells.Jun 26, 2022

Anti-dengue infectivity evaluation of bioflavonoid from Azadirachta indica by dengue virus serine protease inhibition.Mar 08, 2020

Antibacterial and antiproliferative activities of Azadirachta indica leaf extract.Nov 10, 2022

Antibiofilm and anticancer activities of unripe and ripe Azadirachta indica (neem) seed extracts.Feb 13, 2022

Antiproliferative activity of neem leaf extracts obtained by a sequential pressurized liquid extraction.Jul 29, 2018

View the Evidence:
148 Abstracts with Neem Research