Neem

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135 Diseases Researched for Neem
NameACCKFocus
HIV Infections422Locked
Malaria415Locked
Coronavirus Infection514Locked
Head and Neck Cancer314Locked
Metabolic Syndrome X211Locked
Scabies211Locked
AIDS110Locked
Chemotherapy and Radiation Toxicity110Locked
Chemotherapy-Induced Toxicity: Cisplatin110Locked
Dysuria110Locked
Endothelial Dysfunction110Locked
Gastroduodenal Ulcer110Locked
Gastroesophageal Reflux110Locked
Gingivitis110Locked
Head Lice110Locked
Insulin Resistance110Locked
Peptic Ulcer110Locked
Vaginal Discharge: Abnormal110Locked
Breast Cancer88Locked
Hyperglycemia48Locked
Diabetes Mellitus: Type 247Locked
Inflammation57Locked
Prostate Cancer67Locked
Diabetes Mellitus: Type 136Locked
Diabetic Nephropathy36Locked
Liver Cancer56Locked
Oral Cancer56Locked
Cancers: All55Locked
Enterococcus Infections55Locked
Leukemia: Chronic Lymphocytic Leukemia (CLL)15Locked
Staphylococcus aureus infection55Locked
Arthritis24Locked
Brain Inflammation 24Locked
Cervical Cancer44Locked
Colon Cancer34Locked
Kidney Fibrosis24Locked
Lipopolysaccharide-Induced Toxicity34Locked
Lung Cancer44Locked
Oxidative Stress24Locked
Pancreatic Cancer44Locked
Breast Cancer: Triple Negative 33Locked
Candida Albicans33Locked
Escherichia coli Infections33Locked
Lymphoma23Locked
Pseudomonas aeruginosa33Locked
Psoriasis23Locked
Radiotherapy13Locked
Rheumatoid Arthritis23Locked
Wound Healing23Locked
Acute T cell Leukemias12Locked
Alzheimer's Disease22Locked
Anxiety12Locked
Anxiety Disorders12Locked
Arsenic Poisoning12Locked
Benzo[a]pyrene-induced Toxicity 12Locked
Breast Cancer: Chemically-Induced12Locked
Chemically-Induced Liver Damage12Locked
Chemotherapy-Induced Toxicity: Cyclophosphamide12Locked
Chemotherapy-Induced Toxicity: Doxorubicin22Locked
Cholera12Locked
Chronic Obstructive Pulmonary Disease12Locked
Colitis12Locked
Colorectal Cancer22Locked
Dengue22Locked
Dental Caries22Locked
Depression12Locked
Diabetes: Cognitive Dysfunction12Locked
Diabetic Retinopathy12Locked
Diarrhea12Locked
Drug Toxicity: Methotrexate12Locked
Duodenal Ulcer12Locked
Dysbiosis12Locked
Dyslipidemias12Locked
Fluoride Toxicity 12Locked
Gestational Diabetes12Locked
Gram-Positive Bacterial Infections22Locked
Hepatitis12Locked
Hepatitis: Autoimmune 12Locked
Hypertension12Locked
Leukopenia: Chemotherapy Induced12Locked
Multiple Sclerosis12Locked
Nerve Injuries12Locked
Petroleum Exposure And Toxicity12Locked
Salmonella Infections22Locked
Sciatic Nerve Crush Injury12Locked
Smoking12Locked
Squamous cell carcinoma22Locked
Staphylococcus aureus: Methicillin-resistant (MRSA)22Locked
Steptococcus Mutans Infections22Locked
Animal Diseases: Infectious 11Locked
Asthma11Locked
Bladder Cancer11Locked
Cancer Metastasis11Locked
Cancers: Drug Resistant11Locked
Cardiovascular Diseases11Locked
Chickenpox11Locked
Choriocarcinoma11Locked
Citrobacter Infection11Locked
Colic11Locked
Conjunctivitis11Locked
Coxsackievirus Infections11Locked
Dengue Fever11Locked
Denture Stomatitis11Locked
Dysmenorrhea11Locked
Fever11Locked
Foot and Mouth Disease11Locked
Gastric Cancer11Locked
Gastric Ulcer11Locked
Gout11Locked
Gram-Negative Bacterial Infections11Locked
HIV Drug-Induced Toxicity 11Locked
HSV-111Locked
Headache11Locked
Helicobacter Pylori Infection11Locked
Hypercholesterolemia11Locked
Infection: Antibiotic Resistant11Locked
Influenza11Locked
Influenza A11Locked
Insect Bites: Repellent11Locked
Klebsiella Infections11Locked
Muscle Soreness11Locked
Neuroblastoma11Locked
Pancreatitis11Locked
Pancreatitis: Chronic11Locked
Parkinson's Disease11Locked
Periodontal Diseases11Locked
Porphyromonas gingivalis11Locked
Pulmonary Fibrosis11Locked
Pulmonary Fibrosis: Bleomycin-Induced11Locked
Respiratory Infections11Locked
Rheumatism11Locked
Rhinovirus Infection 11Locked
Staphylococcus epidermidis11Locked
Stomach Cancer11Locked
Streptococcus Infections11Locked
71 Pharmacological Actions Researched for Neem
NameACCKFocus
Anti-Inflammatory Agents2843Locked
Antioxidants2029Locked
Apoptotic2025Locked
Antiviral Agents1222Locked
Antiproliferative 1921Locked
Antimicrobial1019Locked
Hypoglycemic Agents416Locked
Immunomodulatory616Locked
Renoprotective714Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor914Locked
Chemoprotective Agents413Locked
NF-kappaB Inhibitor1013Locked
Radioprotective213Locked
Anti-Bacterial Agents1212Locked
Anti-HIV Agents110Locked
Antimalarials110Locked
Prophylactic Agents110Locked
Proton Pump Inhibitor110Locked
Anti-Apoptotic69Locked
Interleukin-1 beta downregulation69Locked
Interleukin-6 Downregulation59Locked
Neuroprotective Agents69Locked
Anti-metastatic78Locked
Antihypertensive Agents47Locked
Bcl-2 protein down-regulation37Locked
Hepatoprotective47Locked
Tumor Suppressor Protein p53 Upregulation37Locked
Alpha-amylase inhibitor36Locked
Anticarcinogenic Agents46Locked
Angiogenesis Inhibitors45Locked
Anti-Fibrotic35Locked
Chemopreventive45Locked
Hypolipidemic35Locked
Cardioprotective34Locked
Cell cycle arrest44Locked
Genoprotective24Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor34Locked
Alpha-glucosidase inhibitor 13Locked
Chemotherapeutic33Locked
Transforming growth factor beta (TGF-β) inhibitor23Locked
Vascular Endothelial Growth Factor Inhibitors23Locked
Anti-Anxiety Agents12Locked
Antidepressive Agents12Locked
Antifungal Agents22Locked
Antimutagenic Agents12Locked
Antineoplastic Agents22Locked
Anxiolytic12Locked
Catalase Up-Regulation12Locked
Drug synergy12Locked
Gastrointestinal Agents12Locked
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor22Locked
Insect Repellents22Locked
Interleukin-17 downregulation12Locked
Nrf2 activation22Locked
Pancreato Protective Agents22Locked
Phase II Detoxification Enzyme Inducer12Locked
Superoxide Dismutase Up-regulation12Locked
Anti-Ulcer Agents11Locked
Anticholesteremic Agents11Locked
Contraceptive Agents11Locked
Cyclin D1 Down-Regulation11Locked
Cytotoxic11Locked
Heme oxygenase-1 up-regulation11Locked
Interleukin-10 upregulation11Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor11Locked
Nitric Oxide Inhibitor11Locked
P-glycoprotein Inhibitors11Locked
Protease Inhibitors11Locked
Quorum Sensing Inhibition11Locked
STAT3 Inhibitor11Locked
Wnt/β-catenin signaling pathway modulation11Locked

View the Evidence:
148 Abstracts with Neem Research

[+]

A polyherbal formual containing Neem, Sapindus and Mentha citrata is superior to Betadine in treating lower abdominal pain, vaginal itching and dysuria in women with symptoms of abnormal vaginal discharge. Oct 01, 2009

Pubmed Data : Asia Pac J Public Health. 2009 Oct;21(4):461-8. PMID: 19783561
Article Published Date : Oct 01, 2009
Study Type : Human Study
Additional Links
Substances : Mentha citrata, Neem, Sapindus
Diseases : Dysuria, Vaginal Discharge: Abnormal
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Aqueous Azadirachta indica extract attenuates insulin resistance to improve glycemic control and endothelial function.Oct 31, 2021

Pubmed Data : J Med Food. 2021 Nov ;24(11):1135-1144. Epub 2021 Sep 28. PMID: 34582720
Article Published Date : Oct 31, 2021
Study Type : Human Study
Additional Links
Substances : Neem
Diseases : Endothelial Dysfunction, Insulin Resistance, Metabolic Syndrome X
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Plant Extracts
[+]

Neem (A. indica) shows strong activity against six bacterial strains.Jan 01, 2007

Pubmed Data : J Herb Pharmacother. 2007;7(3-4):191-201 PMID: 18928141
Article Published Date : Jan 01, 2007
Study Type : Human Study
Additional Links
Substances : Neem
[+]

Neem and Tumeric are a safe and effective topical treatment for scabies. Jan 01, 1992

Pubmed Data : Trop Geogr Med. 1992 Jan;44(1-2):178-81. PMID: 1496714
Article Published Date : Jan 01, 1992
Study Type : Human Study
Additional Links
Substances : Neem, Turmeric
Diseases : Scabies
[+]

Neem bark has therapeutic potential for controlling gastric hypersecretion and gastroesophageal and gastroduodenal uclcers. Oct 29, 2004

Pubmed Data : Life Sci. 2004 Oct 29;75(24):2867-78. PMID: 15454339
Article Published Date : Oct 29, 2004
Study Type : Human Study
Additional Links
Substances : Neem
Diseases : Gastroduodenal Ulcer, Gastroesophageal Reflux, Peptic Ulcer
Pharmacological Actions : Proton Pump Inhibitor
[+]

Neem has antimalarial and anti-HIV activity. Mar 01, 2009

Pubmed Data : Toxicol In Vitro. 2009 Mar;23(2):251-8. Epub 2008 Dec 13. PMID: 15138081
Article Published Date : Mar 01, 2009
Study Type : Human Study
Additional Links
Substances : Neem
Diseases : HIV Infections, Malaria
Pharmacological Actions : Anti-HIV Agents, Antimalarials
Additional Keywords : Plant Extracts
[+]

Neem leaf extract safely increases CD4 cell levels in patients with HIV/AIDS. Jul 01, 2007

Pubmed Data : Am J Ther. 2007 Jul-Aug;14(4):369-74. PMID: 17667213
Article Published Date : Jul 01, 2007
Study Type : Human Study
Additional Links
Substances : Neem
Diseases : AIDS, HIV Infections
[+]

Neem mouthwash can be used as an alternative to chlorhexidine mouthwash.Jun 30, 2017

Pubmed Data : J Contemp Dent Pract. 2017 Jul 1 ;18(7):567-571. Epub 2017 Jul 1. PMID: 28713109
Article Published Date : Jun 30, 2017
Study Type : Human Study
Additional Links
Substances : Neem
Diseases : Gingivitis
Pharmacological Actions : Antimicrobial
Additional Keywords : Mouthwash, Plant Extracts
[+]

Neem oil and St. Johns Wort proved to be a safe and effective option in the management of acute skin toxicity in head and neck cancer patients.Jan 31, 2017

Pubmed Data : Med Oncol. 2017 Feb ;34(2):30. Epub 2017 Jan 18. PMID: 28101834
Article Published Date : Jan 31, 2017
Study Type : Human Study
Additional Links
Substances : Neem, St. Johns Wort
Diseases : Chemotherapy and Radiation Toxicity, Chemotherapy-Induced Toxicity: Cisplatin, Head and Neck Cancer
Pharmacological Actions : Chemoprotective Agents, Radioprotective
[+]

Neem seed extract shampoo is safe and effective in treating head lice infection in children. Jan 01, 2007

Pubmed Data : Parasitol Res. 2007 Jan;100(2):329-32. Epub 2006 Aug 10. PMID: 16900389
Article Published Date : Jan 01, 2007
Study Type : Human Study
Additional Links
Substances : Neem
Diseases : Head Lice
[+]

These results found that patients taking Neem capsules had a 55% less chance of COVID-19 infection.Apr 22, 2021

Pubmed Data : Altern Ther Health Med. 2021 Apr 23. Epub 2021 Apr 23. PMID: 33891569
Article Published Date : Apr 22, 2021
Study Type : Human Study
Additional Links
Substances : Neem
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents, Immunomodulatory, Prophylactic Agents
Additional Keywords : Risk Reduction
[+]

Neem leaf extract exhibits anti-leukemic properties in patient primary chronic lymphocytic leukemia cells.Feb 28, 2014

Pubmed Data : Leuk Lymphoma. 2014 Mar ;55(3):652-61. Epub 2013 Jul 1. PMID: 23721511
Article Published Date : Feb 28, 2014
Study Type : Human In Vitro
Additional Links
Substances : Neem
Diseases : Leukemia: Chronic Lymphocytic Leukemia (CLL)
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Dose Response, Plant Extracts
[+]

Molecular modeling and in vitro studies of gedunin a potent alpha-amylase inhibitor and alpha-glucosidase inhibitor.May 23, 2022

Pubmed Data : Biofactors. 2022 May 24. Epub 2022 May 24. PMID: 35608401
Article Published Date : May 23, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Neem
Diseases : Hyperglycemia
Pharmacological Actions : Alpha-amylase inhibitor, Alpha-glucosidase inhibitor , Hypoglycemic Agents
[+]

Gedunin modulates T lymphocyte responses and ameliorates allergic inflammation.Aug 31, 2012

Pubmed Data : Int Immunopharmacol. 2012 Sep ;14(1):82-93. Epub 2012 Jun 15. PMID: 22709475
Article Published Date : Aug 31, 2012
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Neem
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Holistic care approach for the effective management of severe radiation dermatitis using neem and honey.Sep 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Indian J Palliat Care. 2020 Oct-Dec;26(4):540-543. Epub 2020 Nov 19. PMID: 33623321
Article Published Date : Sep 30, 2020
Study Type : Human: Case Report
Additional Links
Substances : Honey, Neem
Diseases : Head and Neck Cancer, Radiotherapy
Pharmacological Actions : Radioprotective
[+]

Therapeutic role of Azadirachta indica leaves ethanolic extract against diabetic nephropathy in rats neonatally induced by streptozotocin.Nov 01, 2021

Pubmed Data : Ultrastruct Pathol. 2021 Nov 2 ;45(6):391-406. Epub 2021 Oct 31. PMID: 34720017
Article Published Date : Nov 01, 2021
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Diabetic Nephropathy
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Renoprotective, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

A polyphenol-rich fraction of Azadirachta indica could be used for the treatment of hypertension.Jun 18, 2018

Pubmed Data : Drug Res (Stuttg). 2018 Jun 19. Epub 2018 Jun 19. PMID: 29920624
Article Published Date : Jun 18, 2018
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
[+]

A standardized extract of neem has neuroprotective effects in partial sciatic nerve injury.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : EXCLI J. 2017 ;16:546-565. Epub 2017 Apr 18. PMID: 28694757
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Nerve Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

A water extract of neem exhibits gastroprotective effects against ulcers that is safe and effective.Jul 01, 2006

Pubmed Data : Indian J Physiol Pharmacol. 2006 Jul-Sep;50(3):241-9. PMID: 17193895
Article Published Date : Jul 01, 2006
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Duodenal Ulcer
[+]

A. indica may play a significant role in the management of type-2 diabetes mellitusJun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ayurveda Integr Med. 2015 Jul-Sep;6(3):165-174. PMID: 26604551
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypolipidemic
[+]

Antioxidant and chemopreventive effects of Azadirachta indica on lead acetate-induced hepatotoxicity.Dec 30, 2022

Pubmed Data : Niger J Physiol Sci. 2022 Dec 31 ;37(2):219-224. Epub 2022 Dec 31. PMID: 38243572
Article Published Date : Dec 30, 2022
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Chemically-Induced Liver Damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Lead
[+]

Anxiolytic and antidepressant-like activities of aqueous extract of Azadirachta indica.Jan 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2022 Feb ;8(2):e08881. Epub 2022 Feb 3. PMID: 35198760
Article Published Date : Jan 31, 2022
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Anxiety, Depression
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
[+]

Azadirachta indica ameliorates mouse hepatitis virus-induced neuroinflammatory demyelination.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Neurosci. 2020 ;14:116. Epub 2020 May 12. PMID: 32477069
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Neem
Diseases : Brain Inflammation , Hepatitis, Multiple Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents
[+]

Azadirachta indica provides cardio protection by ameliorating oxidative stress in rat model of diabetic mellitus.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Mag. 2016 May ;12(Suppl 3):S371-8. PMID: 27563227
Article Published Date : Apr 30, 2016
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 2, Hyperglycemia
Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Antioxidants, Cardioprotective
[+]

Co-treatment of Nimbolide augmented the anti-arthritic effects of methotrexate while protecting against organ toxicities.Feb 06, 2022

Pubmed Data : Life Sci. 2022 Feb 7 ;295:120372. Epub 2022 Feb 7. PMID: 35143824
Article Published Date : Feb 06, 2022
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Arthritis, Drug Toxicity: Methotrexate
Pharmacological Actions : Hepatoprotective, Renoprotective
[+]

Combating effects of Azadirachta indica leaves extract on biochemical and neuropsychological decline observed in diabetes.Oct 31, 2022

Pubmed Data : Pak J Pharm Sci. 2022 Nov ;35(6(Special)):1725-1731. PMID: 36861235
Article Published Date : Oct 31, 2022
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Diabetes: Cognitive Dysfunction, Diabetes Mellitus: Type 2
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Effects of Azadirachta indica on neuropathic pain induced by chronic constriction injury to sciatic nerve of Wistar rat.Aug 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Adv Vet Anim Res. 2022 Sep ;9(3):359-368. Epub 2022 Sep 29. PMID: 36382046
Article Published Date : Aug 31, 2022
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Sciatic Nerve Crush Injury
Pharmacological Actions : Neuroprotective Agents
[+]

Exploring the prophylactic potential of Azadirachta indica leaf extract against dyslipidemia.Feb 28, 2023

Pubmed Data : J Ethnopharmacol. 2023 Mar 1 ;303:116008. Epub 2022 Dec 12. PMID: 36521768
Article Published Date : Feb 28, 2023
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Dyslipidemias, Oxidative Stress
Pharmacological Actions : Gastrointestinal Agents, Hypolipidemic
Additional Keywords : Plant Extracts
[+]

Extracts of Neem leaf were effective in inducing apoptosis in leukemia and colon cancer cells.Oct 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharm Pharm Sci. 2015 Nov ;18(4):729-46. PMID: 26626256
Article Published Date : Oct 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Neem
Diseases : Acute T cell Leukemias, Colon Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Plant Extracts, Selective Cytotoxicity
[+]

Hematopoietic effects of Azadirachta indica methanolic extract in cyclophosphamide mediated myelosuppression.Aug 31, 2020

Pubmed Data : Pak J Pharm Sci. 2020 Sep ;33(5(Supplementary)):2269-2273. PMID: 33832900
Article Published Date : Aug 31, 2020
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Immunomodulatory
[+]

Improvement in serum amylase and glucose levels after administration of bisdemethoxycurcumin from Curcuma longa and limonoids from Azadirachta indica.Feb 25, 2021

Pubmed Data : J Food Biochem. 2021 Feb 26:e13674. Epub 2021 Feb 26. PMID: 33634871
Article Published Date : Feb 25, 2021
Study Type : Animal Study
Additional Links
Substances : Bisdemethoxycurcumin, Neem
Diseases : Hyperglycemia
Pharmacological Actions : Alpha-amylase inhibitor, Hypoglycemic Agents
[+]

Neem compare favorably to diazepam in reducing anxiety in mice without motor side effects. Jun 01, 2010

Pubmed Data : West Indian Med J. 2010 Jun;59(3):245-8. PMID: 21291100
Article Published Date : Jun 01, 2010
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
Additional Keywords : Benzodiazepine Alternatives, Drug: Diazepam, Plant Extracts
[+]

Neem extract exhibits chemopreventive effects on chemically-induced buccal pouch cancer in hamsters.Jun 01, 2005

Pubmed Data : J Exp Clin Cancer Res. 2005 Jun;24(2):223-30. PMID: 16110755
Article Published Date : Jun 01, 2005
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Oral Cancer
Pharmacological Actions : Anticarcinogenic Agents, Phase II Detoxification Enzyme Inducer
[+]

Neem has an antibacterial, antisecretory and antihemorrhagic activity against Vibrio cholerae.May 22, 2007

Pubmed Data : J Ethnopharmacol. 2007 May 22;111(3):607-12. Epub 2007 Jan 21. PMID: 17314018
Article Published Date : May 22, 2007
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Cholera, Diarrhea
[+]

Neem has anti-clastogenic activity against benzo(a)pyrene induced tumorigenesis.Jul 01, 2010

Pubmed Data : Acta Pol Pharm. 2010 Jul-Aug;67(4):381-90. PMID: 20635534
Article Published Date : Jul 01, 2010
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Benzo[a]pyrene-induced Toxicity , Petroleum Exposure And Toxicity
Pharmacological Actions : Antimutagenic Agents, Antioxidants
Additional Keywords : Plant Extracts
[+]

Neem leaf extract can be considered a potential candidate for protection against renal injury induced by malaria.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Trop Med. 2015 ;2015:961205. Epub 2015 Aug 25. PMID: 26379714
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Malaria
Pharmacological Actions : Renoprotective
Additional Keywords : Plant Extracts
[+]

Neem leaf extract decreased the expression of TNF-α and IL-6 in DSS-induced colitis.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Adv Vet Anim Res. 2020 Dec ;7(4):744-749. Epub 2020 Dec 4. PMID: 33409321
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Neem leaf extract has potential for use in the treatment of chronic obstructive pulmonary disease.Nov 30, 2017

Pubmed Data : Int J Mol Med. 2017 Dec ;40(6):1932-1940. Epub 2017 Oct 10. PMID: 29039495
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Chronic Obstructive Pulmonary Disease, Lipopolysaccharide-Induced Toxicity, Smoking
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Nimbidiol ameliorates renal fibrosis and dysfunction in type-1 diabetes.Dec 14, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2022 Dec 15 ;12(1):21707. Epub 2022 Dec 15. PMID: 36522378
Article Published Date : Dec 14, 2022
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Diabetes Mellitus: Type 1, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Renoprotective
[+]

Nimbidiol protects from renal injury by alleviating redox imbalance in diabetic mice.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2024 ;15:1369408. Epub 2024 May 21. PMID: 38835661
Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Diabetic Nephropathy
Pharmacological Actions : Antioxidants, Renoprotective
[+]

Nimbolide ameliorates the streptozotocin-induced diabetic retinopathy.Jul 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2021 Aug ;28(8):4255-4262. Epub 2021 Jun 19. PMID: 34354407
Article Published Date : Jul 31, 2021
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Diabetic Retinopathy
Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Nimbolide ameliorates unilateral ureteral obstruction-induced renal fibrosis.Dec 31, 2018

Pubmed Data : Mol Immunol. 2019 08 ;112:247-255. Epub 2019 Jun 12. PMID: 31202101
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Renoprotective, Transforming growth factor beta (TGF-β) inhibitor
[+]

Nimbolide attenuated the inflammation in the liver of autoimmune hepatitis's mice through regulation of HDAC3.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Appl Pharmacol. 2022 01 1 ;434:115795. Epub 2021 Nov 12. PMID: 34780724
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Hepatitis: Autoimmune
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Nimbolide attenuates complete Freund's adjuvant induced arthritis.Feb 28, 2023

Pubmed Data : Phytother Res. 2023 Mar ;37(3):903-912. Epub 2022 Nov 27. PMID: 36437579
Article Published Date : Feb 28, 2023
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Arthritis, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-17 downregulation
[+]

Nimbolide has shown promising activity as an anti-psoriatic agent.Jun 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Indian J Pharmacol. 2021 Jul-Aug;53(4):278-285. PMID: 34414905
Article Published Date : Jun 30, 2021
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Psoriasis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Nimbolide inhibits 2D and 3D prostate cancer cells migration, affects microtubules and angiogenesis.Dec 31, 2021

Pubmed Data : Phytomedicine. 2022 Jan ;94:153826. Epub 2021 Nov 1. PMID: 34775358
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Prostate Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative
[+]

Nimbolide protects the pregnant rats from GDM via alteration of inflammation, oxidative stress, and gut microbiota.Feb 24, 2022

Pubmed Data : Environ Toxicol. 2022 Feb 25. Epub 2022 Feb 25. PMID: 35212444
Article Published Date : Feb 24, 2022
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Gestational Diabetes
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Nimbolide represents a novel therapeutic drug for hepatocellular carcinoma treatment.Feb 28, 2022

Pubmed Data : Phytother Res. 2022 Mar 1. Epub 2022 Mar 1. PMID: 35229912
Article Published Date : Feb 28, 2022
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Dysbiosis, Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Gut-Lung-Axis
[+]

Pretreatment with Neem diminishes leukopenia and enhances the effect of chemotherapy. Sep 01, 2006

Pubmed Data : Phytother Res. 2006 Sep;20(9):814-8. PMID: 16807877
Article Published Date : Sep 01, 2006
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Leukopenia: Chemotherapy Induced
Pharmacological Actions : Drug synergy
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Regular consumption of neem oil prevents chemically induced breast cancer.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:2031460. Epub 2019 Apr 7. PMID: 31080481
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

The present investigation provides novel insights into molecular mechanisms of nimbolide inhibited T cell lymphoma progression.Feb 23, 2022

Pubmed Data : Environ Toxicol. 2022 Feb 24. Epub 2022 Feb 24. PMID: 35199915
Article Published Date : Feb 23, 2022
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Lymphoma
Pharmacological Actions : Antiproliferative
[+]

The present study points out the protective effects of A. indica extract on pyramidal neurons in experimental cerebral malaria induced by P. berghei-infection in mice.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Malar J. 2013 ;12:298. Epub 2013 Aug 29. PMID: 23984986
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Brain Inflammation , Malaria
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents
Additional Keywords : Plant Extracts
[+]

The water extract of stem bark of neem possesses significant wound healing property.Jun 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Mag. 2017 Jul ;13(Suppl 2):S316-S320. Epub 2017 Jul 11. PMID: 28808399
Article Published Date : Jun 30, 2017
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Wound Healing
[+]

Thermally activated carbon prepared from neem and acacia arabica leaves were found to have fluoride removal properties.Feb 29, 2008

Pubmed Data : J Environ Biol. 2008 Mar ;29(2):227-32. PMID: 18831380
Article Published Date : Feb 29, 2008
Study Type : Environmental, In Vitro Study
Additional Links
Substances : Acacia arabica, Charcoal , Neem
Additional Keywords : Fluoride In The Water
Problem Substances : Fluoride
[+]

These results suggest that neem leaf extract has beta cell regenerating potential.May 04, 2015

Pubmed Data : West Indian Med J. 2015 May 5. Epub 2015 May 5. PMID: 26716795
Article Published Date : May 04, 2015
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Diabetes Mellitus: Type 1
Additional Keywords : Beta Cell Regeneration, Plant Extracts
[+]

This reports for the first time the genoprotective and antiapoptotic effect of Azadirachta indica against arsenic toxicity. May 03, 2018

Pubmed Data : J Diet Suppl. 2018 May 4 ;15(3):251-268. Epub 2017 Aug 4. PMID: 28777671
Article Published Date : May 03, 2018
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Arsenic Poisoning
Pharmacological Actions : Anti-Apoptotic, Genoprotective
Problem Substances : Arsenic
[+]

This study shows the protective effect of neem on sodium fluoride induced hypertension and genotoxicity.Oct 04, 2017

Pubmed Data : J Basic Clin Physiol Pharmacol. 2017 Oct 5. Epub 2017 Oct 5. PMID: 28981443
Article Published Date : Oct 04, 2017
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Fluoride Toxicity
Pharmacological Actions : Antihypertensive Agents, Antioxidants, Genoprotective
Problem Substances : Sodium Fluoride
[+]

Use of haematological signatures in conjunction with conventional biomarkers to assess Reno-protective effects of Gedunin in diabetic nephropathy.May 31, 2022

Pubmed Data : J Diabetes Metab Disord. 2022 Jun ;21(1):323-332. Epub 2022 Jan 20. PMID: 35673464
Article Published Date : May 31, 2022
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Diabetic Nephropathy
Pharmacological Actions : Renoprotective
[+]

This review is an attempt to assess the antimicrobial efficacy of 10 plant extracts on dental caries and plaque microorganisms.Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Rev. 2015 Jul-Dec;9(18):87-92. PMID: 26392704
Article Published Date : Jun 30, 2015
Study Type : Review
Additional Links
Substances : Curry Leaves, Eucalyptus, Guava, Hibiscus sabdariffa , Holy Basil, Mangifera indica , Neem
Diseases : Dental Caries, Periodontal Diseases, Streptococcus Infections
Pharmacological Actions : Antimicrobial
[+]

A computational prediction of SARS-CoV-2 structural protein inhibitors from Azadirachta indica.May 27, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biomol Struct Dyn. 2020 May 28:1-17. Epub 2020 May 28. PMID: 32462988
Article Published Date : May 27, 2020
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

A review of evolving herbal formulations in management of dengue fever.Aug 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ayurveda Integr Med. 2017 Jul - Sep;8(3):207-210. Epub 2017 Aug 18. PMID: 28823790
Article Published Date : Aug 31, 2017
Study Type : Review
Additional Links
Substances : Neem, Papaya, Sea buckthorn
Diseases : Dengue Fever
[+]

A review of the anticancer activity of Azadirachta indica in oral cancer. Mar 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Oral Biol Craniofac Res. 2020 Apr-Jun;10(2):206-209. Epub 2020 Apr 18. PMID: 32489822
Article Published Date : Mar 31, 2020
Study Type : Review
Additional Links
Substances : Neem
Diseases : Oral Cancer
Pharmacological Actions : Chemopreventive
[+]

A. indica bark extract has a potent antibacterial property against S. aureus, E. faecalis, P. aeruginosa, and P. mirabilis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharm Bioallied Sci. 2019 Jan-Mar;11(1):33-37. PMID: 30906137
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Enterococcus Infections, Pseudomonas aeruginosa, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
[+]

A. indica exhibited the in-vitro immunomodulatory potential to inhibit the continuum of SEB induced CD4+ T-cell activation/ exhaustion.Apr 08, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2021 Apr 9 ;21(1):114. Epub 2021 Apr 9. PMID: 33836748
Article Published Date : Apr 08, 2021
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : HIV Infections
Pharmacological Actions : Immunomodulatory
[+]

A. indica leaf and C. roseus extracts alone or in combination with fluconazole and voriconazole could be promising for the management of candidiasis.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:9373524. Epub 2022 Mar 21. PMID: 35356250
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Candida Albicans, Infection: Antibiotic Resistant, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents, Antifungal Agents
Additional Keywords : Natural Substance/Drug Synergy, Natural Substance Synergy
[+]

All MRSA isolates were found susceptible to organic extracts of A. indica leaves.Jun 30, 2018

Pubmed Data : Pak J Pharm Sci. 2018 Jul ;31(4(Supplementary)):1485-1488. PMID: 30058539
Article Published Date : Jun 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Antimicrobial
[+]

An extract of neem leaf and its bioactive liminoid, nimbolide, suppresses colon cancer in preclinical models.Dec 31, 2017

Pubmed Data : Mol Carcinog. 2018 09 ;57(9):1156-1165. Epub 2018 May 8. PMID: 29697164
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Cancer Metastasis, Colon Cancer, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic
Additional Keywords : Plant Extracts
[+]

Anti-cancer activity of gedunin by induction of apoptosis in human gastric cancer AGS cells.Jun 26, 2022

Pubmed Data : Appl Biochem Biotechnol. 2022 Jun 27. Epub 2022 Jun 27. PMID: 35759172
Article Published Date : Jun 26, 2022
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic
[+]

Anti-dengue infectivity evaluation of bioflavonoid from Azadirachta indica by dengue virus serine protease inhibition.Mar 08, 2020

Pubmed Data : J Biomol Struct Dyn. 2020 Mar 9:1-14. Epub 2020 Mar 9. PMID: 32107969
Article Published Date : Mar 08, 2020
Study Type : In Vitro Study
Additional Links
Substances : Bioflavonoids, Neem
Diseases : Dengue
Pharmacological Actions : Antiviral Agents, Protease Inhibitors
[+]

Antibacterial and antiproliferative activities of Azadirachta indica leaf extract.Nov 10, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2022 Nov 11 ;27(22). Epub 2022 Nov 11. PMID: 36431873
Article Published Date : Nov 10, 2022
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Escherichia coli Infections, Salmonella Infections, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents, Antioxidants, Antiproliferative
Additional Keywords : Plant Extracts
[+]

Antibiofilm and anticancer activities of unripe and ripe Azadirachta indica (neem) seed extracts.Feb 13, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2022 Feb 14 ;22(1):42. Epub 2022 Feb 14. PMID: 35152903
Article Published Date : Feb 13, 2022
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Breast Cancer, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents, Cytotoxic
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation, Plant Extracts
[+]

Antiproliferative activity of neem leaf extracts obtained by a sequential pressurized liquid extraction.Jul 29, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2018 Jul 30 ;11(3). Epub 2018 Jul 30. PMID: 30061479
Article Published Date : Jul 29, 2018
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Breast Cancer, Cervical Cancer, Liver Cancer, Lung Cancer
Pharmacological Actions : Antiproliferative
[+]

Antiproliferative efficacy of the antioxidant bioactive compounds of defatted seeds of Azadirachta indica and Momordica charantia.Jun 07, 2022

Pubmed Data : J Biomol Struct Dyn. 2022 Jun 8:1-15. Epub 2022 Jun 8. PMID: 35674735
Article Published Date : Jun 07, 2022
Study Type : In Vitro Study
Additional Links
Substances : Bitter Melon, Neem
Diseases : Oral Cancer
Pharmacological Actions : Antioxidants, Antiproliferative
[+]

Azadirachta indica A. Juss bark extract and its Nimbin isomers restrict β-coronaviral infection and replication.Feb 14, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Virology. 2022 Feb 15 ;569:13-28. Epub 2022 Feb 15. PMID: 35219218
Article Published Date : Feb 14, 2022
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Azadirachta indica and Moringa oleifera both have an antibacterial effect against Enterococcus faecalis strains.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Dent. 2018 ;2018:1071676. Epub 2018 Sep 25. PMID: 30356384
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Moringa oleifera, Neem
Diseases : Enterococcus Infections
Pharmacological Actions : Anti-Bacterial Agents
[+]

Azadirachta indica and Senna siamea stimulates the production of CD4+ and is not toxic.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Toxicol. 2021 ;2021:5594505. Epub 2021 Jun 23. PMID: 34257647
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Neem, Senna
Diseases : HIV Drug-Induced Toxicity , HIV Infections
Pharmacological Actions : Immunomodulatory
[+]

Azadirachta indica fruit mesocarp and epicarp extracts induce antimicrobial and antiproliferative effects.Jul 29, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Plants (Basel). 2022 Jul 30 ;11(15). Epub 2022 Jul 30. PMID: 35956468
Article Published Date : Jul 29, 2022
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Breast Cancer, Colorectal Cancer, Prostate Cancer
Pharmacological Actions : Antimicrobial, Antiproliferative , Apoptotic
[+]

Azadirachta indica was demonstrated to exhibit neuroprotective antioxidative and anti‑apoptotic effects in Parkinson's disease.May 31, 2018

Pubmed Data : Mol Med Rep. 2018 Jun ;17(6):7959-7965. Epub 2018 Mar 28. PMID: 29620282
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Azadirachtin attenuates lipopolysaccharide-induced ROS production, DNA damage, and apoptosis in Rin-5F pancreatic beta cells.Dec 17, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicines. 2021 Dec 18 ;9(12). Epub 2021 Dec 18. PMID: 34944759
Article Published Date : Dec 17, 2021
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Pancreato Protective Agents
[+]

Catechin obtained from the phytoextract of neem showed a marked ability to inhibit the dental biofilm.Jan 25, 2021

Pubmed Data : Appl Biochem Biotechnol. 2021 Jan 26. Epub 2021 Jan 26. PMID: 33496925
Article Published Date : Jan 25, 2021
Study Type : In Vitro Study
Additional Links
Substances : Catechin , Neem
Diseases : Porphyromonas gingivalis
Pharmacological Actions : Antimicrobial, Quorum Sensing Inhibition
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation
[+]

Computational evaluation of Azadirachta indica-derived bioactive compounds as potential inhibitors of NLRP3 in the treatment of Alzheimer's disease.Jan 17, 2023

Pubmed Data : J Alzheimers Dis. 2023 Jan 18. Epub 2023 Jan 18. PMID: 36683510
Article Published Date : Jan 17, 2023
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Discovery of bioactive natural products for the treatment of acute respiratory infections.Jun 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Planta Med. 2018 Jul ;84(9-10):684-695. Epub 2018 Mar 19. PMID: 29554706
Article Published Date : Jun 30, 2018
Study Type : Review
Additional Links
Substances : Anise, Bael , Black Currant, Black Pepper, Blackberry, Carrot, Chrysanthemum Indicum, Cinnamon, Elderberry, Fennel, Frankincense, Garlic, Honeysuckle, Lemon Balm, Lotus , Marigold, Medicinal Mushrooms, Mugwort, Neem, Oregano, Reishi Mushroom, Rose , Rosemary, White Mulberry , Wormwood
Diseases : Coxsackievirus Infections, Influenza, Respiratory Infections, Rhinovirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Disruption of epigenetic silencing in human colon cancer cells lines utilizing a novel supercritical CO2 extract of neem leaf.Sep 30, 2019

Pubmed Data : Anticancer Res. 2019 Oct ;39(10):5473-5481. PMID: 31570441
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Epigenetic Modification In Cancer, Plant Extracts
[+]

Epoxyazadiradione exhibit activities in head and neck squamous cell carcinoma by targeting multiple pathways.Sep 06, 2020

Pubmed Data : Apoptosis. 2020 Sep 7. Epub 2020 Sep 7. PMID: 32894380
Article Published Date : Sep 06, 2020
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Head and Neck Cancer, Squamous cell carcinoma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Epoxyazadiradione purified from neem seed induced apoptosis in human cervical cancer cells.Nov 30, 2017

Pubmed Data : Phytother Res. 2017 Dec ;31(12):1892-1902. Epub 2017 Oct 18. PMID: 29044755
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor
[+]

Ethanolic extracts from Azadirachta indica leaves modulate transcriptional levels of hormone receptor variant in breast cancer cell lines.Jun 25, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2018 Jun 26 ;19(7). Epub 2018 Jun 26. PMID: 29949923
Article Published Date : Jun 25, 2018
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Chemotherapeutic
[+]

Exploring the therapeutic potential of neem for the treatment of prostate cancer.Jun 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Transl Med. 2022 Jul ;10(13):754. PMID: 35957716
Article Published Date : Jun 30, 2022
Study Type : Review
Additional Links
Substances : Neem
Diseases : Prostate Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Chemotherapeutic
[+]

Extracts of A. indica stem bark had anti-bacterial activity and also exhibited significant antioxidant activity.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2017 Jan ;24(1):11-14. Epub 2015 Aug 6. PMID: 28053565
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Salmonella Infections
Pharmacological Actions : Anti-Bacterial Agents, Antioxidants
Additional Keywords : Natural Substances Versus Drugs
[+]

Extracts of Neem, Noni and Aloe vera showed inhibitory effects against E. faecalis.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Int Soc Prev Community Dent. 2016 May-Jun;6(3):196-9. Epub 2016 May 30. PMID: 27382533
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Aloe Vera, Neem, Noni
Diseases : Gram-Positive Bacterial Infections
Pharmacological Actions : Antimicrobial
Additional Keywords : Plant Extracts
[+]

Gedunin abrogates aldose reductase, PI3K/Akt/mToR, and NF-κB signaling pathways to inhibit angiogenesis in a hamster model of oral carcinogenesis.Jan 31, 2016

Pubmed Data : Tumour Biol. 2016 Feb ;37(2):2083-93. Epub 2015 Sep 5. PMID: 26342697
Article Published Date : Jan 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Oral Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Antineoplastic Agents, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, NF-kappaB Inhibitor
[+]

Gedunin inhibits oligomeric Aβ 1-42-induced microglia activation.Oct 31, 2019

Pubmed Data : Mol Neurobiol. 2019 Nov ;56(11):7851-7862. Epub 2019 May 24. PMID: 31127528
Article Published Date : Oct 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Alzheimer's Disease
Pharmacological Actions : Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation
[+]

Gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathway.Feb 13, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Feb 14 ;8(7):10891-10904. PMID: 26988754
Article Published Date : Feb 13, 2017
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Gedunin may act as an effective GSK-3β inhibitor suggesting that this compound may be used for the management of neuroblastoma.Sep 26, 2021

Pubmed Data : J Biomol Struct Dyn. 2021 Sep 27:1-14. Epub 2021 Sep 27. PMID: 34569452
Article Published Date : Sep 26, 2021
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Neuroblastoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

guava and neem extracts possess compounds containing antibacterial properties. Jan 01, 2007

Pubmed Data : Foodborne Pathog Dis. 2007;4(4):481-8. PMID: 18041957
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Guava, Neem
Diseases : Gram-Negative Bacterial Infections, Gram-Positive Bacterial Infections
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Plant Extracts
[+]

Herbal plants as immunity modulators against COVID-19.Aug 04, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Herb Med. 2021 Aug 5:100501. Epub 2021 Aug 5. PMID: 34377631
Article Published Date : Aug 04, 2021
Study Type : Review
Additional Links
Substances : Aloe Vera, Ashwagandha, Black Pepper, Broccoli, Cinnamon, Ginger, Holy Basil, Licorice, Moringa oleifera, Neem, Turmeric
Diseases : Coronavirus Infection
Pharmacological Actions : Immunomodulatory
[+]

Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells.Aug 31, 2020

Pubmed Data : Life Sci. 2020 Sep 1 ;256:118000. Epub 2020 Jun 22. PMID: 32585246
Article Published Date : Aug 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

In vitro antibacterial activity of nimbolide against Helicobacter pylori.Feb 28, 2022

Pubmed Data : J Ethnopharmacol. 2022 Mar 1 ;285:114828. Epub 2021 Nov 9. PMID: 34763046
Article Published Date : Feb 28, 2022
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Helicobacter Pylori Infection
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Plant Extracts
[+]

In vitro efficacy of Azadirachta indica leaf extract against methicillin resistant Staphylococci isolated from skin infection.Oct 31, 2021

Pubmed Data : Pak J Pharm Sci. 2021 Nov ;34(6(Supplementary)):2303-2308. PMID: 35039267
Article Published Date : Oct 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Antimicrobial
[+]

In-vitro and in-silico antibacterial activity of Azadirachta indica.May 24, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Plant Biol. 2022 May 25 ;22(1):262. Epub 2022 May 25. PMID: 35610569
Article Published Date : May 24, 2022
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Citrobacter Infection, Escherichia coli Infections, Klebsiella Infections, Pseudomonas aeruginosa
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Plant Extracts
[+]

In-vitro morphological assessment of apoptosis induced by nimbolide.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Pharm Res. 2019 ;18(2):846-859. PMID: 31531067
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Lung Cancer, Prostate Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Selective Cytotoxicity
[+]

Individual and synergistic effects of tea tree oil and neem extract on Candida albicans adhesion to denture soft liner.Jul 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cureus. 2022 Aug ;14(8):e27869. Epub 2022 Aug 10. PMID: 36110485
Article Published Date : Jul 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Neem, Tea Tree
Diseases : Candida Albicans, Denture Stomatitis
Pharmacological Actions : Antifungal Agents
Additional Keywords : Natural Substance Synergy
[+]

Involvement of actin cytoskeletal modifications in the inhibition of triple-negative breast cancer growth and metastasis by nimbolide.Mar 25, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Ther Oncolytics. 2021 Mar 26 ;20:596-606. Epub 2021 Feb 24. PMID: 33768141
Article Published Date : Mar 25, 2021
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

Limonoids and tricyclic diterpenoids from Azadirachta indica and their antitumor activities.Jun 30, 2020

Pubmed Data : Bioorg Chem. 2020 Jul ;100:103889. Epub 2020 Apr 28. PMID: 32388432
Article Published Date : Jun 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Cancers: All, Stomach Cancer
Pharmacological Actions : Apoptotic
[+]

Limonoids from seeds of Azadirachta indica and their antibacterial activity.Oct 31, 2019

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2019 Nov ;44(22):4864-4873. PMID: 31872594
Article Published Date : Oct 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Escherichia coli Infections, Pseudomonas aeruginosa, Staphylococcus epidermidis
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Plant Extracts
[+]

Limonoids gedunin and azadiradione from Neem have alpha-Amylase Inhibiting properties. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(10):e0140113. Epub 2015 Oct 15. PMID: 26469405
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Diabetes Mellitus: Type 2, Hyperglycemia
Pharmacological Actions : Alpha-amylase inhibitor, Hypoglycemic Agents
[+]

Mango and neem tree extracts inhibit four organisms associated with dental caries. Oct 01, 2007

Pubmed Data : Indian J Dent Res. 2007 Oct-Dec;18(4):148-51. PMID: 17938488
Article Published Date : Oct 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Mango , Neem
Diseases : Dental Caries, Steptococcus Mutans Infections
[+]

Methanolic neem stem bark extract induces cell cycle arrest, apoptosis and inhibits the migration of cervical cancer cells.Sep 09, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2022 Sep 10 ;22(1):239. Epub 2022 Sep 10. PMID: 36088372
Article Published Date : Sep 09, 2022
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Cervical Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest, Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : Plant Extracts
[+]

Molecular targets of nimbolide for anti-cancer therapy.Dec 31, 2021

Pubmed Data : J Environ Pathol Toxicol Oncol. 2022 ;41(2):69-88. PMID: 35695653
Article Published Date : Dec 31, 2021
Study Type : Review
Additional Links
Substances : Neem
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors, Wnt/β-catenin signaling pathway modulation
[+]

Moringa oleifera and neem showed both potent and significant antiviral activity against foot and mouth disease virus.Jun 30, 2016

Pubmed Data : Pak J Pharm Sci. 2016 Jul ;29(4):1263-8. PMID: 27393440
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Moringa oleifera, Neem
Diseases : Animal Diseases: Infectious , Foot and Mouth Disease
Pharmacological Actions : Antiviral Agents
Additional Keywords : Plant Extracts
[+]

Nanodelivery and anticancer effect of a limonoid, nimbolide, in breast and pancreatic cancer cells.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Nanomedicine. 2019 ;14:8095-8104. Epub 2019 Oct 7. PMID: 31632020
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Breast Cancer, Pancreatic Cancer
Pharmacological Actions : Apoptotic
[+]

Neem and holy basil leaf extracts alleviate arsenic toxicity by reducing arsenic uptake and improving antioxidant system in rice seedlings.Dec 31, 2019

Pubmed Data : Physiol Mol Biol Plants. 2020 Jan ;26(1):63-81. Epub 2019 Nov 27. PMID: 32158121
Article Published Date : Dec 31, 2019
Study Type : Plant Study
Additional Links
Substances : Holy Basil, Neem, Rice
Pharmacological Actions : Antioxidants
Problem Substances : Arsenic
[+]

Neem bark has antiviral activity against herpes simplex virus type-1 infection. Dec 29, 2009

Pubmed Data : Phytother Res. 2009 Dec 29. Epub 2009 Dec 29. PMID: 20041417
Article Published Date : Dec 29, 2009
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : HSV-1
Pharmacological Actions : Antiviral Agents
[+]

Neem compounds have potential activity against influenza viruses.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bioinformation. 2015 ;11(7):359-65. Epub 2015 Jul 31. PMID: 26339153
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Influenza A
Pharmacological Actions : Antiviral Agents
Additional Keywords : Plant Extracts
[+]

Neem contains compounds which induce cell cycle arrest and programmed cell death in cervical cancer cells.Jun 01, 2010

Pubmed Data : Free Radic Res. 2010 Jun;44(6):624-34. PMID: 20429769
Article Published Date : Jun 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Cervical Cancer
Pharmacological Actions : Antioxidants, Apoptotic, Cell cycle arrest
[+]

Neem leaf extract has anticancer activity against a prostate cancer cell line. Apr 21, 2006

Pubmed Data : J Ethnopharmacol. 2006 Apr 21;105(1-2):246-50. Epub 2005 Dec 27. PMID: 16378700
Article Published Date : Apr 21, 2006
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Prostate Cancer
[+]

Neem leaf extract has significant antimicrobial activity against E. faecalis Sep 30, 2016

Pubmed Data : J Contemp Dent Pract. 2016 Oct 1 ;17(10):791-794. Epub 2016 Oct 1. PMID: 27794147
Article Published Date : Sep 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Enterococcus Infections
Pharmacological Actions : Antimicrobial
Additional Keywords : Natural Substances Versus Drugs
[+]

Neem oil as a repellent against Aedes albopictus mosquitoes. Oct 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Insect Sci. 2019 Nov 1 ;19(6). PMID: 31765474
Article Published Date : Oct 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Insect Bites: Repellent
Pharmacological Actions : Insect Repellents
[+]

Neem seed oil inhibits the growth of human breast cancer cells.Jan 26, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2017 08 27 ;18(8):2135-2140. Epub 2017 Aug 27. PMID: 28843234
Article Published Date : Jan 26, 2017
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Plant Oils
[+]

Neem yielded antibacterial activity equivalent to 2% chlorhexidine or sodium hypochlorite against E. faecalis.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bull Tokyo Dent Coll. 2017 ;58(2):103-109. PMID: 28724858
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Neem, Turmeric
Diseases : Enterococcus Infections
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substances Versus Drugs
[+]

Nimbolide abrogates cerulein-induced chronic pancreatitis.Dec 31, 2019

Pubmed Data : Pharmacol Res. 2020 06 ;156:104756. Epub 2020 Mar 16. PMID: 32194177
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Pancreatitis: Chronic
Pharmacological Actions : Anti-Inflammatory Agents, Pancreato Protective Agents
[+]

Nimbolide ameliorates pancreatic inflammation and apoptosis.Dec 31, 2020

Pubmed Data : Int Immunopharmacol. 2021 Jan ;90:107246. Epub 2020 Dec 9. PMID: 33310297
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Pancreatitis
Pharmacological Actions : Anti-Apoptotic, Antioxidants, NF-kappaB Inhibitor
[+]

Nimbolide as a potent anti-fibrotic agent.Sep 30, 2019

Pubmed Data : Int Immunopharmacol. 2019 Oct ;75:105755. Epub 2019 Aug 1. PMID: 31377591
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Pulmonary Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Nimbolide epigenetically regulates autophagy and apoptosis in breast cancer.Aug 31, 2018

Pubmed Data : Toxicol In Vitro. 2018 Sep ;51:114-128. Epub 2018 May 17. PMID: 29778718
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Epigenetic Modification In Cancer
[+]

Nimbolide exerts protective effects in complete Freund's adjuvant induced inflammatory arthritis.Jan 31, 2021

Pubmed Data : Life Sci. 2021 Feb 1 ;266:118911. Epub 2020 Dec 16. PMID: 33333049
Article Published Date : Jan 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, STAT3 Inhibitor
[+]

Nimbolide exhibits anticancer effect by reducing tumor size, tumor burden and by suppressing cell cycle progression in liver cancer.Dec 06, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2020 Dec 7 ;26(45):7131-7152. PMID: 33362373
Article Published Date : Dec 06, 2020
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Inflammation, Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Cyclin D1 Down-Regulation, NF-kappaB Inhibitor
[+]

Nimbolide induces cell death in T lymphoma cells: Implication of altered apoptosis and glucose metabolism.Mar 31, 2021

Pubmed Data : Environ Toxicol. 2021 Apr ;36(4):628-641. Epub 2020 Dec 4. PMID: 33274819
Article Published Date : Mar 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Lymphoma
Pharmacological Actions : Antiproliferative , Apoptotic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]

Nimbolide inhibits angiogenesis in breast cancer.Feb 03, 2022

Pubmed Data : Anticancer Agents Med Chem. 2022 Feb 4. Epub 2022 Feb 4. PMID: 35125086
Article Published Date : Feb 03, 2022
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Breast Cancer
Pharmacological Actions : Angiogenesis Inhibitors
[+]

Nimbolide is a potential chemotherapeutic agent for bladder cancer. Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:3753587. Epub 2019 Jul 14. PMID: 31391858
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Bladder Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Cell cycle arrest, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Nimbolide is a promising candidate for the anticancer drug arsenal.Jan 07, 2021

Pubmed Data : J Med Chem. 2021 04 8 ;64(7):3560-3577. Epub 2021 Mar 19. PMID: 33739088
Article Published Date : Jan 07, 2021
Study Type : Review
Additional Links
Substances : Neem
Diseases : Cancers: All
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Anti-metastatic, Antiproliferative , Apoptotic
[+]

Nimbolide prevents myocardial damage by regulating cardiac biomarkers, antioxidant level, and apoptosis signaling against doxorubicin-induced cardiotoxicity.Jul 05, 2020

Pubmed Data : J Biochem Mol Toxicol. 2020 Jul 6:e22543. Epub 2020 Jul 6. PMID: 32627270
Article Published Date : Jul 05, 2020
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Chemoprotective Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Nimbolide reduces CD44 positive cell population and induces mitochondrial apoptosis in pancreatic cancer cells.Jan 27, 2018

Pubmed Data : Cancer Lett. 2018 01 28 ;413:82-93. Epub 2017 Oct 26. PMID: 29107110
Article Published Date : Jan 27, 2018
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Pancreatic Cancer
Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Nimbolide, a compound from Azadirachta indica (Neem), inhibits proliferation and induces programmed cell death in human choriocarcinoma cells. Jun 01, 2009

Pubmed Data : Invest New Drugs. 2009 Jun;27(3):246-52. Epub 2008 Aug 22. PMID: 18719855
Article Published Date : Jun 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Choriocarcinoma
[+]

NLGP counterbalances the immunosuppressive effect of tumor-associated mesenchymal stem cells to restore effector T cell functions.Jan 22, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Stem Cell Res Ther. 2019 09 23 ;10(1):296. Epub 2019 Sep 23. PMID: 31547863
Article Published Date : Jan 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative , Immunomodulatory
[+]

P-gp modulating effect of Azadirachta indica extract in multidrug-resistant cancer cell lines.Jan 31, 2018

Pubmed Data : Pharmazie. 2018 Feb 1 ;73(2):104-109. PMID: 29442013
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Cancers: All, Cancers: Drug Resistant, Colon Cancer, Liver Cancer
Pharmacological Actions : P-glycoprotein Inhibitors
Additional Keywords : Plant Extracts
[+]

Protective effect of gedunin on TLR-mediated inflammation by modulation of inflammasome activation and cytokine production.Dec 31, 2016

Pubmed Data : Pharmacol Res. 2017 01 ;115:65-77. Epub 2016 Sep 15. PMID: 27641928
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Review on pharmacological and toxicologyical effects of oleum azadirachti oil.Sep 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Trop Biomed. 2013 Oct ;3(10):834-40. Epub 2013 Sep 4. PMID: 24075352
Article Published Date : Sep 30, 2013
Study Type : Review
Additional Links
Substances : Neem
Diseases : Asthma, Cardiovascular Diseases, Chickenpox, Colic, Conjunctivitis, Dysmenorrhea, Fever, Gastric Ulcer, Gout, Headache, Malaria, Muscle Soreness, Psoriasis, Rheumatism, Scabies
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Anti-Ulcer Agents, Antimicrobial, Antiviral Agents, Contraceptive Agents, Insect Repellents
Additional Keywords : Plant Oils
[+]

Screening of potential drug from Azadiractha Indica extracts for SARS-CoV-2.Oct 02, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Mol Struct. 2020 Oct 3:129390. Epub 2020 Oct 3. PMID: 33041371
Article Published Date : Oct 02, 2020
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

The active compound from the neem leaf extract was effective against the envelope protein of all four types of dengue virus.Nov 30, 2015

Pubmed Data : Virusdisease. 2015 Dec ;26(4):243-54. Epub 2015 Nov 20. PMID: 26645034
Article Published Date : Nov 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Dengue
Pharmacological Actions : Antiviral Agents
Additional Keywords : Plant Extracts
[+]

The anti-cancer properties of neem through its antioxidant activity in the liver.May 09, 2021

Pubmed Data : J Complement Integr Med. 2021 May 10. Epub 2021 May 10. PMID: 33964199
Article Published Date : May 09, 2021
Study Type : Review
Additional Links
Substances : Neem
Diseases : Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Hepatoprotective, Tumor Suppressor Protein p53 Upregulation
[+]

The antimicrobial potential of the neem tree Azadirachta indica. Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:891535. Epub 2022 May 30. PMID: 35712721
Article Published Date : Dec 31, 2021
Study Type : Review
Additional Links
Substances : Neem
Diseases : Candida Albicans, Enterococcus Infections, Staphylococcus aureus infection, Steptococcus Mutans Infections
Pharmacological Actions : Antimicrobial
[+]

The highly pure neem leaf extract inhibits tumorigenesis in oral squamous cell carcinoma.Dec 31, 2018

Pubmed Data : Front Oncol. 2019 ;9:890. Epub 2019 Sep 13. PMID: 31572681
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive
[+]

The present study suggested nimbolide as a potent chemotherapeutic and chemopreventive agent.Apr 30, 2017

Pubmed Data : Pak J Pharm Sci. 2017 May ;30(3(Suppl.)):967-973. PMID: 28655693
Article Published Date : Apr 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Lung Cancer, Prostate Cancer
Pharmacological Actions : Chemopreventive, Chemotherapeutic
[+]

The protective effect of Azadirachta indica (neem) against metabolic syndrome.Feb 28, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2021 Mar ;24(3):280-292. PMID: 33995939
Article Published Date : Feb 28, 2021
Study Type : Review
Additional Links
Substances : Neem
Diseases : Metabolic Syndrome X
Pharmacological Actions : Antihypertensive Agents, Antioxidants, Hypolipidemic, Nrf2 activation
[+]

These findings reveal the potential of catechin, epicatechin and garlic extracts for the treatment of acute and chronic wounds.Jun 01, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2023 Jun 2 ;23(1):181. Epub 2023 Jun 2. PMID: 37268940
Article Published Date : Jun 01, 2023
Study Type : In Vitro Study
Additional Links
Substances : Catechin , Curcumin, Epicatechin, Garlic, Neem, Pomegranate
Diseases : Wound Healing
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

This finding is in support to traditional uses of A. indica as cholesterol-lowering agents and regulator of gastrointestinal motility.Dec 18, 2017

Pubmed Data : Nat Prod Res. 2017 Dec 19:1-4. Epub 2017 Dec 19. PMID: 29258345
Article Published Date : Dec 18, 2017
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Hypercholesterolemia
Pharmacological Actions : Anticholesteremic Agents
[+]

This study found that neem and licorice were more effective than ibuprofen in suppressing LPS-induced inflammation in C2C12 cells.Aug 31, 2014

Pubmed Data : Nat Prod Commun. 2014 Sep ;9(9):1351-6. PMID: 25918809
Article Published Date : Aug 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Licorice, Neem
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Plant Extracts, Superiority of Natural Substances versus Drugs
Problem Substances : Ibuprofen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

This study gives a proof of concept that encapsulation of nimbolide in PLGA nanoparticles increases its therapeutic effect on pancreatospheres.Feb 28, 2022

Pubmed Data : Toxicol In Vitro. 2022 Mar ;79:105293. Epub 2021 Dec 6. PMID: 34883246
Article Published Date : Feb 28, 2022
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Pancreatic Cancer
Additional Keywords : Cancer Stem Cells
[+]

This summarizes the results of preclinical trials that investigated the cardioprotective effects of phytochemicals against DOX-induced cardiotoxicity.May 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Jun ;90:935-946. Epub 2017 Apr 26. PMID: 28460429
Article Published Date : May 31, 2017
Study Type : Review
Additional Links
Substances : Astragalus, Chokeberry, Neem
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Cardioprotective, Chemoprotective Agents

Copyright: marilyna / 123RF Stock Photo

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