Nettle

Name	AC	CK
Diabetes Mellitus: Type 2	14	82
Prostatic Hyperplasia: Benign	5	25
Inflammation	9	22
Oxidative Stress	8	21
Insulin Resistance	5	18
Diabetes: Oxidative Stress	2	12
C-Reactive Protein	1	10
Hot Flash	1	10
Menopausal Syndrome	1	10
Osteoarthritis	1	10
Prostatitis: Chronic	1	10
Urinary Flow Problems	1	10
Diabetic Complications	5	9
Brain Inflammation	3	6
Obesity	3	6
Breast Cancer	4	5
Aflatoxicosis	2	4
Anxiety	2	4
Brain: Oxidative Stress	2	4
Colon Cancer	3	4
Diabetes: Cognitive Dysfunction	2	4
Ischemia	2	4
Lipid Peroxidation	2	4
Memory Disorders: Drug-Induced	2	4
Arthritis	2	3
Prostate Cancer	3	3
Wound Healing	2	3
Aging	1	2
Alzheimer's Disease	1	2
Androgen-Induced Diseases	1	2
Arthritis: Rheumatoid	2	2
Asthma	1	2
Atherosclerosis	1	2
Bleeding: Excessive	1	2
Breast Cancer: Triple Negative	2	2
Chemically-Induced Liver Damage	1	2
Chemotherapy-Induced Kidney Damage	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Chronic Pain	1	2
Cognitive Decline/Dysfunction	1	2
Colitis	1	2
Depression	1	2
Depressive Disorder	1	2
Diabetes Mellitus: Type 2: Prevention	1	2
Diabetic Nephropathy	1	2
Diabetic Neuropathy	1	2
Endometriosis	1	2
Epilepsy: Drug-Induced	1	2
Excitotoxicity	1	2
Gastric Cancer	2	2
Gastric Ulcer	1	2
High Fructose Diet	1	2
Hypercholesterolemia	1	2
Hyperglycemia	1	2
Hypertension	1	2
Liver Cancer	2	2
Memory Disorders	1	2
Memory Loss	1	2
Mercury Poisoning	1	2
Mitochondrial Dysfunction	1	2
Neuropathies	1	2
Nicotine/Tobacco Toxicity	1	2
Pain	1	2
Pancreatitis	1	2
Parkinson's Disease	1	2
Pesticide Toxicity	1	2
Polycystic Ovary Syndrome	1	2
Prostatic Hyperplasia	1	2
Severe Acute Respiratory Syndrome	1	2
Stress	1	2
Surgery: Oral	1	2
Acne	1	1
Acute Myeloid Leukemia	1	1
Acute lymphoblastic leukemia (ALL)	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Cardiovascular Diseases	1	1
Colorectal Cancer	1	1
Coronavirus Infection	1	1
Dengue	1	1
HIV Infections	1	1
Heart Disease	1	1
Inflammatory Bowel Diseases	1	1
Kidney Stones	1	1
Leishmaniasis	1	1
Melanoma	1	1
Rheumatoid Arthritis	1	1
Rotavirus Infections	1	1
Staphylococcus aureus infection	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1

Name	AC	CK
Antioxidants	29	73
Anti-Inflammatory Agents	24	55
Hypoglycemic Agents	10	52
Interleukin-6 Downregulation	5	17
Hypolipidemic	3	14
Neuroprotective Agents	6	12
Superoxide Dismutase Up-regulation	2	12
Antiproliferative	9	11
Apoptotic	10	11
Nitric Oxide Enhancer	2	11
Tumor Necrosis Factor (TNF) Alpha Inhibitor	5	9
Renoprotective	4	8
Hepatoprotective	4	7
Analgesics	3	6
Anti-Apoptotic	3	6
Cyclooxygenase 2 Inhibitors	3	5
Pancreato Protective Agents	3	5
Anti-Anxiety Agents	2	4
Antidepressive Agents	2	4
Antihypertensive Agents	2	4
Antiviral Agents	3	4
Chemoprotective Agents	2	4
Regenerative	2	4
Anticarcinogenic Agents	2	3
Cell cycle arrest	3	3
Chemopreventive	2	3
Malondialdehyde Down-regulation	2	3
Nitric Oxide Inhibitor	2	3
Acetylcholinesterase Inhibitor	1	2
Alpha-amylase inhibitor	2	2
Alpha-glucosidase inhibitor	2	2
Anti-Androgen	1	2
Anti-Bacterial Agents	2	2
Anti-Ulcer Agents	1	2
Anti-atherogenic	1	2
Anticholesteremic Agents	1	2
Anticonvulsants	1	2
Antinoceceptive	1	2
Calcium Channel Blockers	1	2
Catalase Up-Regulation	1	2
Chemosensitizer	2	2
Cytoprotective	1	2
Gastrointestinal Agents	1	2
Gastroprotective	1	2
Glutathione Upregulation	1	2
Insulin Sensitizers	1	2
Interleukin-1 beta downregulation	1	2
Osteogenic	1	2
Osteoprotective	1	2
Spermatogenic	1	2
Vascular Endothelial Growth Factor Inhibitors	1	2
Vasodilator Agents	1	2
12-lipoxygenase (12-LOX)	1	1
Adenosine deaminase inhibitor	1	1
Angiotensin-Converting Enzyme Inhibitors	1	1
Anti-metastatic	1	1
Antimicrobial	1	1
Antimutagenic Agents	1	1
Bcl-2 protein down-regulation	1	1
Cardioprotective	1	1
Chemotherapeutic	1	1
Insulin-mimetic	1	1
Interleukin-8 downregulation	1	1
Leishmanicidal	1	1
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1
MicroRNA modulator	1	1

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation

Additional Keywords : Plant Extracts

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A hydro alcoholic extract of nettle increased the levels of TAC and SOD in patients with type 2 diabetes.Jan 14, 2012

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Pubmed Data : Pak J Biol Sci. 2012 Jan 15 ;15(2):98-102. PMID: 22545363

Article Published Date : Jan 14, 2012

Study Type : Human Study

Additional Links

Substances : Nettle

Diseases : Diabetes Mellitus: Type 2, Oxidative Stress

Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

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Extracts of Nettle may decrease risk factors of cardiovascular incidence and other complications in patients with diabetes mellitus.Oct 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Avicenna J Phytomed. 2016 Nov-Dec;6(6):686-695. PMID: 28078249

Pharmacological Actions : Pancreato Protective Agents, Regenerative

Additional Keywords : Plant Extracts

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Nettle extract can decrease the growth of breast tumors and induce apoptosis in tumor cells.Apr 20, 2017

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Pubmed Data : Clin Breast Cancer. 2017 Apr 21. Epub 2017 Apr 21. PMID: 28501502

Article Published Date : Apr 20, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Nettle

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

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Nettle extract might prove to be effective for stress mediated neurological disorders.Jul 27, 2016

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Pubmed Data : Biomed Pharmacother. 2016 Jul 28 ;83:676-686. Epub 2016 Jul 28. PMID: 27470568

Article Published Date : Jul 27, 2016

Study Type : Animal Study

Additional Links

Substances : Nettle

Diseases : Cognitive Decline/Dysfunction, Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Nitric Oxide Inhibitor

Additional Keywords : Plant Extracts

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Nettle extract treatment was associated with less apoptosis in an experimental acute pancreatitis model in rats.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2016 ;16(1):101. Epub 2016 Mar 15. PMID: 26980377

Article Published Date : Dec 31, 2015

Study Type : Animal Study, In Vitro Study

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Substances : Nettle

Diseases : Diabetes Mellitus: Type 2, Diabetes Mellitus: Type 2: Prevention, Insulin Resistance

Therapeutic Actions : Exercise: Swimming

Pharmacological Actions : Hypoglycemic Agents, Insulin Sensitizers, Regenerative

Additional Keywords : Plant Extracts

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The protective role of Urtica dioica seed extract against azoxymethane-induced colon carcinogenesis.Feb 08, 2021

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Pubmed Data : Nutr Cancer. 2021 Feb 9:1-14. Epub 2021 Feb 9. PMID: 33560145

Article Published Date : Feb 08, 2021

Study Type : Animal Study

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Substances : Nettle

Diseases : Colon Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors

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The unexplored wound healing activity of Urtica dioica L. extract.Oct 14, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2021 Oct 15 ;26(20). Epub 2021 Oct 15. PMID: 34684829

Article Published Date : Oct 14, 2021

Study Type : Animal Study, In Vitro Study

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Substances : Nettle

Diseases : Wound Healing

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiproliferative , Cell cycle arrest

Additional Keywords : Plant Extracts

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These results provides support for anxiolytic activity of Urtica urens.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2021 Apr 8 ;139:111577. Epub 2021 Apr 8. PMID: 33839493

Article Published Date : Apr 07, 2021

Study Type : Animal Study

Additional Links

Substances : Nettle

Diseases : Brain Inflammation , Diabetes: Cognitive Dysfunction

Therapeutic Actions : Exercise

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

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Urtica dioica extract had hypoglycemic and antidiabetic activities with no deleterious effect on hepatic enzymes.Aug 31, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Med Sci. 2012 Sep ;37(3):181-6. PMID: 23115450

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Metab Brain Dis. 2014 Mar ;29(1):121-30. Epub 2014 Jan 17. PMID: 24435938

Article Published Date : Feb 28, 2014

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Antileishmanial activity of Urtica dioica extract against zoonotic cutaneous leishmaniasisDec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Afr J Tradit Complement Altern Med. 2014 ;11(5):38-40. Epub 2014 Aug 23. PMID: 25395702

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Elderberry, Nettle

Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA), Staphylococcus aureus infection

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Plant Extracts

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Generally used nutritional extracts of these plants have in vitro antiviral activity against rotavirus.Jul 25, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Virol J. 2012 Jul 26 ;9:137. Epub 2012 Jul 26. PMID: 22834653

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The levels of ORAC in nettles was higher in leaf samples collected before and during flowering from the continental habitats.Jan 17, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Biomed Pharmacother. 2017 Jun 16 ;93:95-102. Epub 2017 Jun 16. PMID: 28628833

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Cancer Prev. 2013 ;14(9):5317-23. PMID: 24175819

Article Published Date : Dec 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Nettle

Diseases : Breast Cancer

Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Urtica dioica L. inhibits proliferation and enhances cisplatin cytotoxicity in NSCLC cells.Mar 20, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2013 ;Suppl 59:OL1882-8. Epub 2013 Nov 3. PMID: 24199953

Article Published Date : Dec 31, 2012

Study Type : Plant Study

Additional Links

Substances : Nettle

Pharmacological Actions : Antioxidants

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View the Evidence: 114 Abstracts with Nettle Research

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Effects of Urtica dioica on metabolic profiles in type 2 diabetes.Sep 28, 2021

The findings of the present study suggest that nettle supplementation may be effective in controlling fasting blood sugar for T2DM patients.Dec 03, 2019

A combination of fish oil, nettle and vitamin E (Phytalgic) decreases the neeed for analgesics and NSAIDs and improves symptoms of osteoarthritis. Dec 16, 2009

A combination of Saw Palmetto, Nettle, Curcumin and Quercetin significantly improves treatment outcome of prulifloxacin in bacterial prostatitis patients. Jun 01, 2009

A hydro alcoholic extract of nettle could decrease the levels of IL-6 and hs-CRP in patients with type 2 diabetes.Jul 31, 2011

A hydro alcoholic extract of nettle increased the levels of TAC and SOD in patients with type 2 diabetes.Jan 14, 2012

Extracts of Nettle may decrease risk factors of cardiovascular incidence and other complications in patients with diabetes mellitus.Oct 31, 2016

Nettle may safely improve glycemic control in type 2 diabetic patients needing insulin therapy.Dec 31, 2012

Nettles has beneficial effects in the treatment of Benign Prostatic Hyperplasia.Jan 01, 2005

This study showed a potential antihyperglycemic and triglyceride lowering effect of the herbal formulation.Dec 31, 2016

Urtica dioica can decrease menopausal hot flashes and increase the quality of life of postmenopausal women.May 31, 2019

Urtica dioica root extract consumption for 12 weeks among BPH patients had clinically significant effects on IPSS, serum hs-CRP, MDA and SOD activity.Dec 31, 2019

Hyperthyroidism treatment by alternative therapies based on cupping and dietary-herbal supplementation.Aug 11, 2021

A hydro-alcoholic extract of Nettle could increase the quality of spermatozoa and inhibits nicotine-induced effects on sperm parameters.May 31, 2014

A methanolic extract of Nettle has a protective capacity and antioxidant activity against cisplatin toxicity.Jun 30, 2012

Ameliorative effect of cotreatment with the methanolic leaf extract of Urtica dioica on acute kidney injury induced by gentamicin. Apr 30, 2020

An ethanolic extract of Urtica urens protects against the toxicity of imidacloprid on bone remodeling in rats.Jun 30, 2017

An extract of Urtica dioica L. mitigates obesity induced insulin resistance in mice skeletal muscle.Dec 31, 2015

An extract of Urtica dioica seeds has a protective hepatorenal effect in broilers affected by aflatoxicosis.Mar 03, 2016

An herbal formula containing Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum and Urtica dioica may dental surgery bleedings. Apr 01, 2009

Antidepressant and anxiolytic like effects of Urtica dioica leaves in streptozotocin induced diabetic mice.Apr 26, 2018

Antiepileptic effects of antioxidant potent extract from Urtica dioica.Jan 31, 2021

Antioxidant and wound healing potential of saponins extracted from the leaves of Algerian Urtica dioica.Apr 30, 2017

Beneficial effects of Urtica dioica on scopolamine-induced memory impairment.May 09, 2018

Combined Sabal and Urtica extracts exert anti-proliferative and anti-inflammatory effects in a model of benign prostate hyperplasia.Dec 31, 2018

Effects of endurance exercise and Urtica dioica on the functional, histological and molecular aspects of the hippocampus in STZ-induced diabetes. Jun 27, 2020

Ethanolic extract of nettle prevents establishment of atherosclerotic lesions in rat aorta.Apr 30, 2018

Evaluation of the antidiabetic potential of extracts of Urtica dioica, Apium graveolens, and Zingiber officinale.Jul 13, 2021

Fresh nettle leaves are a natural protective herb that may play a beneficial role in the prevention of Hg intoxication.Nov 30, 2015

Metagenomic insights into the effects of Urtica dioica vegetable on the gut microbiota.Feb 01, 2021

Nettle could be another therapeutic alternative for relieving pain and for minimising the use of drugs that have long-term secondary effects.Nov 19, 2017

Nettle distillate regenerates pancreatic beta cells in streptozotocin-Induced diabetic rats.Feb 28, 2018

Nettle extract can decrease the growth of breast tumors and induce apoptosis in tumor cells.Apr 20, 2017

Nettle extract might prove to be effective for stress mediated neurological disorders.Jul 27, 2016

Nettle extract treatment was associated with less apoptosis in an experimental acute pancreatitis model in rats.Dec 31, 2013

Nettle has a protective effect against proximal tubule damage after I/R injury in the rat kidney. Nov 30, 2012

Nettle has protective effects on experimental testicular ischemia reperfusion injury in rats.Jul 07, 2016

Nettle inhibits testosterone-induced prostatic hyperplasia. Sep 01, 2008

Nettle leaf extract has considerable anti-inﬂammatory and analgesic activities.Dec 31, 2012

Nettle seed (Urtica dioica) is hepatoprotective in rats with aflatoxicosis. Feb 01, 2009

Nettle showed results comparable to rosiglitazone in reversing the long standing diabetes induced complications.Sep 26, 2013

Nettle supplementation attenuates excitotoxin-induced brain lesions and memory loss in rats. Dec 12, 2008

Nigella sativa and nettle decrease lipid peroxidation and liver enzymes, and increase the antioxidant defence system activity in CCl4-treated rats.May 31, 2003

Peganum harmala seeds, Rhus coriaria, and Urtica dioica had significant antidiabetic, hypolipidemic, and liver and renal damage recovering effects.Jul 31, 2015

Pioglitazone plus nettle has synergistic protective effects against STZ-induced nephropathy.Apr 30, 2017

Polysaccharides from Urtica lobatifolia have anti-aging effects in animal model of aging.Nov 30, 2015

Prostatic hyperplasia could be reduced by oral administration of nettle root extract.Dec 31, 2014

Quercetin can efficiently prevent stress induced neurological complications by rescuing brain from oxidative and inflammatory stress.Mar 14, 2017

Stinging nettle seed oil could be a potential agent in ameliorating colonic inflammation.Nov 30, 2011

Systemic administration of stinging nettle may be effective in accelerating new bone formation and reducing inflammation.Aug 31, 2016

The aerial parts of U. dioica exhibited promising activity in the endometriosis.Jul 16, 2019

The antiulcer activity of the nettle extract was comparable with the effect of buckthorn oil.Dec 31, 2010

The effect of lutein and Urtica dioica extract on in vitro production of embryo and oxidative status in polycystic ovary syndrome in a model of mice.Feb 07, 2021

The in vivo data from this study suggested that UD and exercise training could cure diabetic rats.Dec 31, 2015

The protective role of Urtica dioica seed extract against azoxymethane-induced colon carcinogenesis.Feb 08, 2021

The unexplored wound healing activity of Urtica dioica L. extract.Oct 14, 2021

These results provides support for anxiolytic activity of Urtica urens.Dec 31, 2014

This finding justifies the medicinal application of U. dioica in the management of hypertension.Dec 31, 2015

This herbal extract could have anti-dementia properties and improve spatial learning and memory in sporadic Alzheimer's disease rat model.Jun 30, 2016

This study indicates the anti-hypercholesterolemic effects of Urtica dioica extract in an animal model.Apr 30, 2009

U. dioica vegetable protects against diet induced obesity.Apr 09, 2020

UD leaves extract acts via insulin signalling pathway and might prove to be effective for diabetes mediated central nervous system complications.Jan 13, 2016

Urtica dioica agglutinin or an analog might be a potential therapy for treating SARS-CoV infections.Mar 31, 2011

Urtica dioica attenuates ovalbumin-induced inflammation and lipid peroxidation of lung tissues in rat asthma model.Nov 30, 2017

Urtica dioica extract and exercise training ameliorate cognitive dysfunction.Apr 07, 2021

Urtica dioica extract had hypoglycemic and antidiabetic activities with no deleterious effect on hepatic enzymes.Aug 31, 2012

Urtica dioica extracts abolish scopolamine-induced neuropathies.Jan 05, 2021

Urtica dioica is a potential therapeutic agent for oxidative stress associated with neurodegenerative diseases.Jun 24, 2021

Urtica dioica L. leaf extract modulates blood pressure and oxidative stress in spontaneously hypertensive rats.Jul 14, 2018

Urtica dioica protected the dopaminergic neurons probably by reducing mito-oxidative damage, neuroinflammation, and cellular alteration.Sep 12, 2016

Urtica dioica reversed dexamethasone induced hyperglycemia and its associated complications such as depressive like behavior and cognitive dysfunction.Feb 28, 2014

Urtica dioica showed a therapeutic potential for the attenuation of oxidative stress and diabetes-induced hyperglycemia.Apr 17, 2018

Nettle

View the Evidence:
114 Abstracts with Nettle Research