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Nigella sativa (aka Black Seed)
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234 Diseases Researched for Nigella sativa (aka Black Seed)
Name
AC
CK
Focus
Oxidative Stress
30
103
Diabetes Mellitus: Type 2
16
78
Inflammation
16
70
Obesity
7
65
Asthma
9
57
Hyperglycemia
5
45
Helicobacter Pylori Infection
5
41
Hypertension
9
41
Coronavirus Infection
10
33
Chemotherapy and Radiation Toxicity
7
30
Dyspepsia
3
30
Hashimoto's thyroiditis
3
30
Insulin Resistance
6
28
Lipid Peroxidation
13
25
Breast Cancer
10
24
Nonalcoholic fatty liver disease (NAFLD)
4
23
Rheumatoid Arthritis
4
23
High Cholesterol
2
22
Triglycerides: Elevated
2
21
Allergic Rhinitis
2
20
C-Reactive Protein
2
20
C-Reactive Protein (CRP)
1
20
Cardiovascular Disease: Prevention
1
20
Hyperlipidemia
6
19
Chemically-Induced Liver Damage
9
18
Chemotherapy-Induced Toxicity: Cisplatin
9
18
Endothelial Dysfunction
5
17
Cognitive Decline/Dysfunction
4
16
Diabetic Complications
9
16
Memory Disorders
5
16
Cardiovascular Diseases
5
15
Wound Healing
4
15
Diabetic Nephropathy
3
14
Dyslipidemias
4
14
Liver Cancer
7
14
Drug-Induced Toxicity: Methotrexate
3
13
Kidney Stones
3
13
Asthma: Bronchial
3
12
Chemical Weapon Agent Injury
2
12
Cholesterol: LDL/HDL ratio
2
12
Diabetes: Oxidative Stress
6
12
HDL: Low
2
12
Metabolic Diseases
2
12
Osteoarthritis
2
12
Radiation Induced Illness: Mucositis
2
12
Rhinosinusitis
2
12
Hepatitis C
2
11
Mastalgia
2
11
A1C
1
10
Acne
1
10
Acute Myeloid Leukemia
1
10
Acute lymphoblastic leukemia (ALL)
1
10
Behcet Disease
1
10
Cancers: All
10
10
Chemotherapy-Induced Phlebitis (CIP)
1
10
Chemotherapy-Induced Toxicity: Gentamicin
5
10
Cholesterol: High
1
10
Chronic Kidney Disease (CKD)
1
10
Dermatitis
1
10
Diabetes: Glycation/A1C
1
10
Diabetic Ulcer
1
10
Dysmenorrhea
1
10
Eosinophilia
1
10
Epilepsy: Childhood
1
10
Infertility: Male
1
10
Metabolic Syndrome X
1
10
Opiate Addiction/Withdrawal
1
10
Osteoarthritis: Knee
1
10
Pharyngitis
1
10
Sickle Cell Anemia
1
10
Sperm Quality: Low
1
10
Tonsillitis
1
10
Vitiligo
1
10
Neurodegenerative Diseases
7
9
Acetaminophen (Tylenol) Toxicity
4
8
Ischemia
5
8
Kidney Damage
5
8
Lipopolysaccharide-Induced Toxicity
4
8
Cervical Cancer
3
7
Colon Cancer
4
7
Staphylococcus aureus: Methicillin-resistant (MRSA)
3
7
Alcohol Toxicity
3
6
Brain: Oxidative Stress
3
6
Fibrosis
4
6
Hydrogen Peroxide Induced Toxicity
2
6
Hyperinsulinism
3
6
Hypothyroidism
3
6
Lead Poisoning
3
6
Osteoporosis
3
6
Pain
4
6
Alzheimer's Disease
5
5
Coronavirus Disease
1
5
Multiple Sclerosis
3
5
Severe Acute Respiratory Syndrome
1
5
Anxiety
2
4
Cadmium Poisoning
2
4
Chemotherapy-Induced Toxicity: Cyclophosphamide
2
4
Chemotherapy-Induced Toxicity: Doxorubicin
3
4
Chronic Pain
2
4
Diabetes Mellitus: Type 1
2
4
Epilepsy
3
4
Fatigue: Excercise-Induced
2
4
Gastritis
2
4
HIV Infections
2
4
Kidney Cancer
2
4
Liver Damage
3
4
Menopausal Syndrome
2
4
Morphine Tolerance/Dependence
2
4
Pulmonary Fibrosis: Bleomycin-Induced
2
4
Schistosomiasis
2
4
Seizures
2
4
Staphylococcus aureus infection
4
4
Aflatoxicosis
2
3
Allergies
3
3
Escherichia coli Infections
3
3
Fungal Infection
2
3
Gastric Ulcer
2
3
Hypercholesterolemia
2
3
Hypoglycemia
2
3
Parkinson's Disease
3
3
Salmonella Infections
3
3
Abdominal Adhesions
1
2
Aging
1
2
Arthritis
1
2
Aspirin-Induced Toxicity
1
2
Bacillus Cereus infection
2
2
Bacillus subtilis infections
2
2
Bacterial Infections
2
2
Bisphenol Toxicity
1
2
Breast Cancer: Chemically-Induced
1
2
Cancers: Radiation-Induced
1
2
Candidiasis
1
2
Candidiasis: Vulvovaginal
1
2
Cataract: Radiation-Induced
1
2
Central Nervous System Diseases
2
2
Cerebral Hypoperfusion
1
2
Cerebral Ischemia
1
2
Chemotherapy-Induced Toxicity: Kidney
1
2
Chemotherapy-Induced Toxicity: Tamoxifen
1
2
Cholestasis
1
2
Corticosteroid-Induced Toxicity
1
2
Cytomegalovirus Infections
1
2
DNA damage
1
2
Dementia
1
2
Diabetic Microangiopathy
1
2
Diabetic Neuropathies
1
2
Diabetic Neuropathy
1
2
Diarrhea
1
2
Drug-Induced Toxicity
1
2
Drug-Induced Toxicity: Cyclosporine
1
2
Drug-Induced Toxicity: Gastrointestinal
1
2
Encephalomyelitis
1
2
Food Allergies
1
2
Formaldehyde Toxicity
1
2
Fructose-Induced Toxicity
1
2
Gram-Negative Bacterial Infections
2
2
Gram-Positive Bacterial Infections
2
2
HIV Drug-Induced Toxicity
1
2
Hearing Loss: Noise-Induced
1
2
High Fat Diet
1
2
High Fructose Diet
1
2
High Homocysteine
1
2
Inflammatory Bowel Diseases
1
2
Intestinal Ischemia
1
2
Keratitis
1
2
Kidney Cancer: Prevention
1
2
Kidney Damage: Chemically-Induced
1
2
Kidney Damage: Drug-Induced
1
2
Kidney Fibrosis
1
2
Learning disorders
1
2
Liver Damage: Aflatoxin-Induced
1
2
Lung Cancer
1
2
Lung Damage
1
2
Lung Injury: Smoke-Induced
1
2
Malaria
1
2
Mucosal Damage: Radiation Induced
1
2
Myocardial Fibrosis
1
2
Myocardial Ischemia
1
2
Nicotine/Tobacco Toxicity
1
2
Oral Mucositis
1
2
Osteopenia
1
2
Ovarian Failure
1
2
Pancreatic Cancer
2
2
Pesticide Toxicity
1
2
Postmenopausal Disorders
1
2
Prenatal Chemical Exposures
1
2
Radiotherapy
1
2
Sodium nitrate toxicity
1
2
Spinal Cord Injuries
1
2
Stomach Cancer
1
2
Thyroid Diseases
1
2
Toxoplasma gondii Infection
1
2
Toxoplasmosis
1
2
Traumatic Brain Injury
2
2
Ulcerative Colitis
1
2
Urolithiasis
1
2
Atherosclerosis
1
1
Autoimmune Diseases
1
1
Bacterial Infections: Resistance/Biofilm Formation
1
1
Blastocystis hominis infections
1
1
Brain Ischemia
1
1
Breast Milk: Inadequate/Poor Quality
1
1
Cancer Metastasis
1
1
Chemotherapy-Induced Kidney Damage
1
1
Chlamydia trachomatis
1
1
Chronic Disease
1
1
Chronic Obstructive Pulmonary Disease
1
1
Clostridium Infections
1
1
Cough
1
1
Depression
1
1
Diabetes
1
1
Fungus Diseases
1
1
Histamine: Elevated
1
1
Hodgkin Lymphoma
1
1
Hypersensitivity: Respiratory
1
1
Infection: Antibiotic Resistant
1
1
Kidney Diseases
1
1
Klebsiella Infections
1
1
Leishmaniasis
1
1
Liver Disease
1
1
Liver Diseases
1
1
Lung Diseases
1
1
Lymphoma
1
1
MRSA
1
1
Nephrolithiasis
1
1
Neurotoxicity
1
1
Ovarian Cancer
1
1
Parasitic Diseases
1
1
Periodontal Diseases
1
1
Pseudomonas aeruginosa
1
1
Pulmonary Emphysema
1
1
Respiratory Diseases
1
1
Rheumatism
1
1
Ulcers
1
1
93 Pharmacological Actions Researched for Nigella sativa (aka Black Seed)
Name
AC
CK
Focus
Antioxidants
92
222
Anti-Inflammatory Agents
56
188
Hypoglycemic Agents
23
133
Hypolipidemic
21
121
Anticholesteremic Agents
8
66
Chemoprotective Agents
23
60
Hepatoprotective
23
59
Anti-Bacterial Agents
14
54
Antihypertensive Agents
11
53
Neuroprotective Agents
26
47
Superoxide Dismutase Up-regulation
11
47
Renoprotective
19
43
Analgesics
10
40
Radioprotective
10
36
Immunomodulatory
12
33
Malondialdehyde Down-regulation
16
32
Anti-Asthmatic Agents
3
31
Tumor Necrosis Factor (TNF) Alpha Inhibitor
8
31
Interleukin-6 Downregulation
7
29
Antiproliferative
17
28
Apoptotic
19
27
Prophylactic Agents
3
24
Bronchodilator Agents
3
22
Anti-Ulcer Agents
6
19
Antiviral Agents
12
19
Cardioprotective
5
16
Insulin Sensitizers
4
16
Anti-Apoptotic
8
14
Anticarcinogenic Agents
8
14
Gastroprotective
7
14
Chemotherapeutic
3
12
NF-kappaB Inhibitor
3
12
Vascular Endothelial Growth Factor Inhibitors
2
12
Chemopreventive
6
11
Anti-Fibrotic
6
10
Fertility Agents: Male
1
10
Hypotensive
1
10
Malonaldehyde (MDA) Down-Regulation
1
10
Pancreato Protective Agents
5
10
anti-inflammatory
1
10
Antifungal Agents
7
9
Anti-metastatic
6
7
Antimicrobial
7
7
Nitric Oxide Inhibitor
4
7
Tumor Suppressor Protein p53 Upregulation
3
7
Angiogenesis Inhibitors
5
6
Anticonvulsants
4
6
Antineoplastic Agents
2
6
Antinoceceptive
3
5
Caspase-3 Activation
1
5
Caspase-8 activation
1
5
Caspase-9 Activation
1
5
Interleukin-1 beta downregulation
3
5
Anti-Anxiety Agents
2
4
Antiparasitic Agents
3
4
Cyclooxygenase 2 Inhibitors
4
4
Cytoprotective
2
4
Insulin-releasing
2
4
Gastrointestinal Agents
2
3
Heme oxygenase-1 up-regulation
2
3
Acetylcholinesterase Inhibitor
1
2
Analgesics: Non-Narcotic
1
2
Anti-Allergic Agents
2
2
Anticholinergic
1
2
Antimalarials
1
2
Antioxidant
1
2
Antitussive Agents
2
2
Chondroprotective
1
2
Genoprotective
1
2
Gluconeogenesis Inhibitor
1
2
Histamine Antagonists
1
2
Histamine down-regulation
2
2
Interferon Inducers
1
2
MicroRNA modulator
1
2
Osteoprotective
1
2
Remyelination
1
2
Vascular Endothelial Growth Factor A Inhibitor
1
2
Vasodilator Agents
1
2
Anti-Retroviral Agents
1
1
Anti-cancer
1
1
Antibacterial Effects
1
1
Antidepressive Agents
1
1
Antispasmodic
1
1
Bcl-2 protein down-regulation
1
1
Cell cycle arrest
1
1
Cyclooxygenase 1 Inhibitor
1
1
Galactogogue
1
1
Leishmanicidal
1
1
Leukotriene Antagonists
1
1
Leukotriene D4 antagonist
1
1
Postaglandin PGE2 downregulation
1
1
STAT3 Inhibitor
1
1
Wound Healing Effects
1
1
Research Articles
356
Cumulative Knowledge Score
576
Overall Research Rating
EXCELLENT
Related Topics
Nigella sativa (aka Black Seed) is a Sub of the following Topics
Seeds
Culinary Herbs and Spices
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View the Evidence:
471 Abstracts with Nigella sativa (aka Black Seed) Research
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[+]
Antihypertensive effects of Nigella sativa supplementation.
Jul 31, 2023
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2023 Aug ;37(8):3224-3238. Epub 2023 Jun 21. PMID:
37341696
Article Published Date
: Jul 31, 2023
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
[+]
Nigella sativa and health outcomes: An overview of systematic reviews and meta-analyses.
Dec 31, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Nutr. 2023 ;10:1107750. Epub 2023 Mar 28. PMID:
37057067
Article Published Date
: Dec 31, 2022
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetes Mellitus: Type 2
,
Hypercholesterolemia
,
Hypertension
,
Nonalcoholic fatty liver disease (NAFLD)
,
Obesity
,
Osteoporosis
Pharmacological Actions
:
Antihypertensive Agents
,
Hypolipidemic
,
Osteoprotective
[+]
Nigella sativa supplementation improves cardiometabolic indicators in population with prediabetes and type 2 diabetes mellitus.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Nutr. 2022 ;9:977756. Epub 2022 Aug 11. PMID:
36034891
Article Published Date
: Dec 31, 2021
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Hypoglycemic Agents
,
Hypolipidemic
[+]
The effectiveness of herbal medicines on cyclic mastalgia.
Sep 30, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Rev Bras Ginecol Obstet. 2022 Oct ;44(10):972-985. Epub 2022 Nov 29. PMID:
36446563
Article Published Date
: Sep 30, 2022
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Chamomile
,
Cinnamon
,
Isoflavones
,
Nigella sativa (aka Black Seed)
Diseases
:
Mastalgia
Additional Keywords
:
Plant Extracts
[+]
The therapeutic effects of Nigella sativa on skin disease.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2022 ;2022:7993579. Epub 2022 Dec 5. PMID:
36518853
Article Published Date
: Dec 31, 2021
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Skin Diseases
[+]
A systematic review and meta-analysis of the effect of Nigella sativa supplementation on obesity indices.
May 31, 2018
Click here to read the entire abstract
Pubmed Data
: Complement Ther Med. 2018 Jun ;38:48-57. Epub 2018 Apr 11. PMID:
29857879
Article Published Date
: May 31, 2018
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
Current findings suggest N. sativa supplementation a suitable choice in managing the complications of T2D.
Nov 30, 2017
Click here to read the entire abstract
Pubmed Data
: Complement Ther Med. 2017 Dec ;35:6-13. Epub 2017 Aug 30. PMID:
29154069
Article Published Date
: Nov 30, 2017
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Hypoglycemic Agents
,
Hypolipidemic
[+]
Effect of Nigella sativa in the treatment of nonalcoholic fatty liver disease/
Mar 15, 2021
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2021 Mar 16. Epub 2021 Mar 16. PMID:
33728708
Article Published Date
: Mar 15, 2021
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
[+]
Effectiveness of medicinal plants for glycaemic control in type 2 diabetes.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2021 ;12:777561. Epub 2021 Nov 26. PMID:
34899340
Article Published Date
: Dec 31, 2020
Study Type
: Meta Analysis
Additional Links
Substances
:
Astragalus
,
Nigella sativa (aka Black Seed)
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Hypoglycemic Agents
[+]
Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress.
May 10, 2020
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2020 May 11. Epub 2020 May 11. PMID:
32394508
Article Published Date
: May 10, 2020
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hyperglycemia
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticholesteremic Agents
,
Hypoglycemic Agents
,
Hypolipidemic
[+]
N. sativa consumption has a significant lowering effect on glycemic status.
Mar 13, 2019
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2019 Mar 14. Epub 2019 Mar 14. PMID:
30873688
Article Published Date
: Mar 13, 2019
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hyperglycemia
Pharmacological Actions
:
Hypoglycemic Agents
[+]
Nigella Sativa has a significant impact on plasma lipid concentrations, leading to lower total cholesterol.
Feb 09, 2016
Click here to read the entire abstract
Pubmed Data
: Pharmacol Res. 2016 Feb 10. Epub 2016 Feb 10. PMID:
26875640
Article Published Date
: Feb 09, 2016
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Cardiovascular Disease: Prevention
,
High Cholesterol
,
Triglycerides: Elevated
Pharmacological Actions
:
Anticholesteremic Agents
[+]
Nigella sativa supplementation may provide additional benefits for the treatment of asthma.
Nov 28, 2019
Click here to read the entire abstract
Pubmed Data
: Am J Emerg Med. 2019 Nov 29. Epub 2019 Nov 29. PMID:
31892440
Article Published Date
: Nov 28, 2019
Study Type
: Meta Analysis
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Asthma
Pharmacological Actions
:
Anti-Asthmatic Agents
[+]
Nigella sativa supplementation may provide additional benefits for the treatment of asthma.
Jul 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Postepy Dermatol Alergol. 2021 Aug ;38(4):561-565. Epub 2020 Feb 24. PMID:
34658694
Article Published Date
: Jul 31, 2021
Study Type
: Meta Analysis
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Asthma
Pharmacological Actions
:
Anti-Asthmatic Agents
[+]
Promising preventive and therapeutic effects of TaibUVID nutritional supplements for COVID-19.
Dec 31, 2019
Click here to read the entire abstract
Pubmed Data
: Am J Blood Res. 2020 ;10(5):266-282. Epub 2020 Oct 15. PMID:
33224571
Article Published Date
: Dec 31, 2019
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Chamomile
,
Honey
,
Nigella sativa (aka Black Seed)
Diseases
:
Coronavirus Infection
Pharmacological Actions
:
Prophylactic Agents
[+]
Supplementation with N. sativa exerts a moderate effect on reduction in body weight, body mass index and waist circumference.
Mar 16, 2018
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2018 Mar 17. Epub 2018 Mar 17. PMID:
29559374
Article Published Date
: Mar 16, 2018
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
The effect of Nigella sativa on oxidative stress and inflammatory biomarkers.
Jan 04, 2021
Click here to read the entire abstract
Pubmed Data
: J Complement Integr Med. 2021 Jan 5 ;18(2):235-259. Epub 2021 Jan 5. PMID:
34187123
Article Published Date
: Jan 04, 2021
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
This meta-analysis suggests that Nigella sativa supplementation in humans may benefit as an antioxidant.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: ScientificWorldJournal. 2020 ;2020:2390706. Epub 2020 May 6. PMID:
32454800
Article Published Date
: Dec 31, 2019
Study Type
: Meta Analysis
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Superoxide Dismutase Up-regulation
[+]
This meta-analysis suggests that short-term treatment with N. sativa powder can significantly reduce SBP and DBP levels.
Aug 09, 2016
Click here to read the entire abstract
Pubmed Data
: J Hypertens. 2016 Aug 10. Epub 2016 Aug 10. PMID:
27512971
Article Published Date
: Aug 09, 2016
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
[+]
This meta-analysis suggests thatN. sativa seed and seed oil supplementation can significantly reduce serum CRP level.
Jul 31, 2019
Click here to read the entire abstract
Pubmed Data
: Complement Ther Med. 2019 Aug ;45:149-155. Epub 2019 Jun 14. PMID:
31331553
Article Published Date
: Jul 31, 2019
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
C-Reactive Protein (CRP)
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
A proprietary black cumin oil extract modulates stress-sleep-immunity axis safely.
Dec 31, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Nutr. 2023 ;10:1152680. Epub 2023 Apr 17. PMID:
37139438
Article Published Date
: Dec 31, 2022
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Pharmacological Actions
:
Immunomodulatory
[+]
A randomized controlled trial of a herbal compound for improving metabolic parameters in diabetic patients with uncontrolled dyslipidemia.
Feb 05, 2019
Click here to read the entire abstract
Pubmed Data
: Endocr Metab Immune Disord Drug Targets. 2019 Feb 6. Epub 2019 Feb 6. PMID:
30727929
Article Published Date
: Feb 05, 2019
Study Type
: Human Study
Additional Links
Substances
:
Aloe Vera
,
Fenugreek
,
Milk Thistle
,
Nigella sativa (aka Black Seed)
,
Psyllium
Diseases
:
Diabetes Mellitus: Type 2
,
Dyslipidemias
Pharmacological Actions
:
Hypolipidemic
[+]
Black cumin (Nigella sativa) and Phyllanthus niruri provide symptomatic relief in the treatment of acute tonsillo-pharyngitis patients.
Jun 01, 2008
Click here to read the entire abstract
Pubmed Data
: Int J Clin Pharmacol Ther. 2008 Jun;46(6):295-306. PMID:
18541126
Article Published Date
: Jun 01, 2008
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Phyllanthus niruri (Stonebreaker)
Diseases
:
Pharyngitis
,
Tonsillitis
Additional Keywords
:
Plant Extracts
[+]
Black cumin (Nigella sativa) has a prophylactic effect on chemical war victims.
Nov 01, 2008
Click here to read the entire abstract
Pubmed Data
: J Altern Complement Med. 2008 Nov;14(9):1137-44. PMID:
18991514
Article Published Date
: Nov 01, 2008
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemical Weapon Agent Injury
[+]
Black cumin (Nigella sativa) is effective in long-term treatment of opioid dependence.
Apr 01, 2008
Click here to read the entire abstract
Pubmed Data
: J Ayub Med Coll Abbottabad. 2008 Apr-Jun;20(2):118-24. PMID:
19385474
Article Published Date
: Apr 01, 2008
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Opiate Addiction/Withdrawal
[+]
Black cumin alleviates symptoms of allergic rhinitis.
Oct 12, 2010
Click here to read the entire abstract
Pubmed Data
: Am J Otolaryngol. 2010 Oct 12. Epub 2010 Oct 12. PMID:
20947211
Article Published Date
: Oct 12, 2010
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Allergic Rhinitis
[+]
Black cumin possesses clinical useful anti-H. pylori activity compared to triple therapy.
Jul 01, 2010
Click here to read the entire abstract
Pubmed Data
: Saudi J Gastroenterol. 2010 Jul-Sep;16(3):207-14. PMID:
20616418
Article Published Date
: Jul 01, 2010
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Dyspepsia
,
Helicobacter Pylori Infection
Pharmacological Actions
:
Anti-Bacterial Agents
,
Anti-Ulcer Agents
Additional Keywords
:
Drug: Amoxicillin
,
Drug: Omeprazole
,
Drug-Plant-Vitamin Synergies
,
Natural Substances Versus Drugs
,
Plant Extracts
[+]
Black cumin seeds decreased Methotrexate hepatotoxicity and improved survival in children with ALL
Mar 19, 2015
Click here to read the entire abstract
Pubmed Data
: Infect Disord Drug Targets. 2015 Mar 20. Epub 2015 Mar 20. PMID:
25809628
Article Published Date
: Mar 19, 2015
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Acute lymphoblastic leukemia (ALL)
,
Drug-Induced Toxicity: Methotrexate
Pharmacological Actions
:
Chemotherapeutic
,
Hepatoprotective
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Black cumin seeds have significant anti-diabetic effects in type 2 diabetics.
Oct 01, 2010
Click here to read the entire abstract
Pubmed Data
: Indian J Physiol Pharmacol. 2010 Oct-Dec;54(4):344-54. PMID:
21675032
Article Published Date
: Oct 01, 2010
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
A1C
,
Diabetes: Glycation/A1C
,
Diabetes Mellitus: Type 2
,
Insulin Resistance
Pharmacological Actions
:
Hypoglycemic Agents
,
Insulin Sensitizers
Additional Keywords
:
Beta Cell Protection
,
Beta Cell Regeneration
[+]
Black cumin seeds improves serum lipids, atherogenic index of plasma and modulates anthropometric features in patients with Hashimoto's thyroiditis.
Mar 26, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Lipids Health Dis. 2018 Mar 27 ;17(1):59. Epub 2018 Mar 27. PMID:
29587770
Article Published Date
: Mar 26, 2018
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hashimoto's thyroiditis
Pharmacological Actions
:
Hypolipidemic
[+]
Consumption of Nigella sativa can reduce the inflammatory biomarkers in patients with NAFLD.
May 31, 2019
Click here to read the entire abstract
Pubmed Data
: Complement Ther Med. 2019 Jun ;44:204-209. Epub 2019 Apr 22. PMID:
31126557
Article Published Date
: May 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Daily intake of N. sativa oil for two months improves abnormal semen quality in infertile men without any adverse effects.
May 14, 2014
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2014 May 15 ;21(6):901-5. Epub 2014 Mar 25. PMID:
24680621
Article Published Date
: May 14, 2014
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Infertility: Male
,
Sperm Quality: Low
Pharmacological Actions
:
Fertility Agents: Male
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Dosin eradicated H. pylori in about 57% of infected patients.
Oct 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran Red Crescent Med J. 2016 Nov ;18(11):e23771. Epub 2016 Jun 21. PMID:
28191328
Article Published Date
: Oct 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Honey
,
Nigella sativa (aka Black Seed)
Diseases
:
Helicobacter Pylori Infection
Pharmacological Actions
:
Anti-Bacterial Agents
[+]
Effect of Nigella sativa L. seed oil on urinary incontinence and quality of life in menopausal women.
Jan 13, 2023
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2023 Jan 14. Epub 2023 Jan 14. PMID:
36640148
Article Published Date
: Jan 13, 2023
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Incontinence: Urinary
[+]
Effect of Nigella sativa oil extracts on inflammatory and oxidative stress markers in Behcet's disease.
Feb 29, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Avicenna J Phytomed. 2020 Mar-Apr;10(2):181-189. PMID:
32257890
Article Published Date
: Feb 29, 2020
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Behcet Disease
Pharmacological Actions
:
Antioxidants
,
Malonaldehyde (MDA) Down-Regulation
[+]
Effect of Nigella sativa oil on oxidative stress, inflammatory, and glycemic control indices in diabetic hemodialysis patients.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2022 ;2022:2753294. Epub 2022 Apr 15. PMID:
35463059
Article Published Date
: Dec 31, 2021
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hemodialysis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Hypoglycemic Agents
[+]
Effectiveness of topical Nigella sativa for vitiligo treatment.
Apr 24, 2019
Click here to read the entire abstract
Pubmed Data
: Dermatol Ther. 2019 Apr 25:e12949. Epub 2019 Apr 25. PMID:
31025474
Article Published Date
: Apr 24, 2019
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Vitiligo
[+]
Effects of Nigella sativa extract on chronic rhinosinusitis.
Nov 30, 2021
Click here to read the entire abstract
Pubmed Data
: Indian J Otolaryngol Head Neck Surg. 2021 Dec ;73(4):455-460. Epub 2021 Jan 2. PMID:
34722227
Article Published Date
: Nov 30, 2021
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Rhinosinusitis
Pharmacological Actions
:
Anti-Bacterial Agents
[+]
Effects of resistance training and nigella sativa on type 2 diabetes.
Feb 20, 2021
Click here to read the entire abstract
Pubmed Data
: Arch Physiol Biochem. 2021 Feb 21:1-9. Epub 2021 Feb 21. PMID:
33612031
Article Published Date
: Feb 20, 2021
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetes Mellitus: Type 2
Therapeutic Actions
:
Exercise: Resistance Training
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hypolipidemic
[+]
Efficacy of nigella sativa oil on endothelial function and atherogenic indices in patients with coronary artery diseases.
Jul 23, 2022
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2022 Jul 24. Epub 2022 Jul 24. PMID:
35871718
Article Published Date
: Jul 23, 2022
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Coronary Artery Disease
,
Endothelial Dysfunction
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
[+]
Honey and celery seeds could be beneficial in bronchial asthma.
May 31, 2019
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2019 Jun ;22(6):543-550. Epub 2019 May 24. PMID:
31135254
Article Published Date
: May 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
Celery seed
,
Honey
,
Nigella sativa (aka Black Seed)
Diseases
:
Asthma: Bronchial
Pharmacological Actions
:
Anti-Asthmatic Agents
[+]
Honey and Nigella sativa against COVID-19.
Nov 23, 2022
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2022 Nov 24. Epub 2022 Nov 24. PMID:
36420866
Article Published Date
: Nov 23, 2022
Study Type
: Human Study
Additional Links
Substances
:
Honey
,
Nigella sativa (aka Black Seed)
Diseases
:
Coronavirus Infection
Pharmacological Actions
:
Antiviral Agents
[+]
It is recommended that clinicians and wound care nurses use aloe vera gel instead of Nigella sativa oil gel for the topical treatment of diabetic ulcers.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Evid Based Integr Med. 2018 Jan-Dec;23:2515690X18772804. PMID:
29717629
Article Published Date
: Dec 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
Aloe Vera
,
Nigella sativa (aka Black Seed)
Diseases
:
Diabetic Ulcer
,
Wound Healing
[+]
N sativa supplementation with inhaled maintenance therapy improves some measures of pulmonary function and inflammation in partly controlled asthma.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Ann Saudi Med. 2017 Jan-Feb;37(1):64-71. PMID:
28151459
Article Published Date
: Dec 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Asthma
Pharmacological Actions
:
Bronchodilator Agents
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
N. sativa administration in patients with HCV was tolerable, safe, decreased viral load, and improved oxidative stress, clinical condition and glycemic control in diabetic patients.
Apr 27, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Article Published Date
: Apr 27, 2013
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hepatitis C
[+]
N. sativa could be a promising, safe, and easily available analgesic supplement in women suffering from primary dysmenorrhea.
Aug 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oman Med J. 2020 Sep ;35(5):e167. Epub 2020 Sep 9. PMID:
32953142
Article Published Date
: Aug 31, 2020
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Dysmenorrhea
Pharmacological Actions
:
Analgesics
[+]
N. sativa extract significantly decreases the severity of acute radiation dermatitis and delays the onset of moist desquamation in breast cancer patients.
Nov 30, 2019
Click here to read the entire abstract
Pubmed Data
: Complement Ther Med. 2019 Dec ;47:102205. Epub 2019 Oct 3. PMID:
31780017
Article Published Date
: Nov 30, 2019
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Breast Cancer
,
Chemotherapy and Radiation Toxicity
,
Dermatitis
Pharmacological Actions
:
Radioprotective
[+]
N. sativa hydrogel had significant effects on improving the symptoms of acne vulgaris with acceptable tolerability.
Jun 16, 2020
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2020 Jun 17. Epub 2020 Jun 17. PMID:
32548864
Article Published Date
: Jun 16, 2020
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Acne
Pharmacological Actions
:
Anti-Bacterial Agents
[+]
N. sativa is demonstrated to have significant positive effects on disappearance or reduction of size of kidney stones.
Mar 13, 2019
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2019 Mar 14. Epub 2019 Mar 14. PMID:
30873671
Article Published Date
: Mar 13, 2019
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Kidney Stones
[+]
N. sativa oil improves vascular NO and FMD in subjects with cardiovascular risk factors.
Apr 30, 2022
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2022 May ;36(5):2236-2245. Epub 2022 Apr 12. PMID:
35412685
Article Published Date
: Apr 30, 2022
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Cardiovascular Diseases
,
Endothelial Dysfunction
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
N. sativa oil supplementation along with alpha-keto analogue is efficacious and safe in delaying the progression of disease patients with CKD Stages 3 and 4.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Saudi J Kidney Dis Transpl. 2020 Jan-Feb;31(1):21-31. PMID:
32129194
Article Published Date
: Dec 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chronic Kidney Disease (CKD)
Pharmacological Actions
:
Renoprotective
Additional Keywords
:
Risk Reduction
[+]
N. sativa oil was found to be effective as an add-on therapy in patients of insulin resistance syndrome.
Dec 31, 2007
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Diabetes Dev Ctries. 2008 Jan ;28(1):11-4. PMID:
19902033
Article Published Date
: Dec 31, 2007
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypoglycemic Agents
[+]
N. sativa seed oil has clinical effectiveness comparable to topical diclofenac in the treatment of cyclic mastalgia.
Nov 18, 2015
Click here to read the entire abstract
Pubmed Data
: Planta Med. 2015 Nov 19. Epub 2015 Nov 19. PMID:
26584456
Article Published Date
: Nov 18, 2015
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Mastalgia
Pharmacological Actions
:
Analgesics
Additional Keywords
:
Natural Substances Versus Drugs
Problem Substances
:
Diclofenac
[+]
N. sativa seed supplementation during specific immunotherapy of allergic rhinitis may be considered a potential adjuvant therapy.
Dec 31, 2009
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Med Princ Pract. 2010 ;19(3):206-11. Epub 2010 Mar 29. PMID:
20357504
Article Published Date
: Dec 31, 2009
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Allergic Rhinitis
Pharmacological Actions
:
Immunomodulatory
Additional Keywords
:
Phytotherapy
,
Significant Treatment Outcome
[+]
N. sativa seeds is beneficial in relieving the symptoms of knee osteoarthritis.
Apr 04, 2017
Click here to read the entire abstract
Pubmed Data
: Int J Rheum Dis. 2017 Apr 5. Epub 2017 Apr 5. PMID:
28378356
Article Published Date
: Apr 04, 2017
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Osteoarthritis
Additional Keywords
:
Significant Treatment Outcome
[+]
Nigella sativa (black cumin) has potent antiasthmatic properties.
Feb 08, 2010
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2010 Feb 8. Epub 2010 Feb 8. PMID:
20149611
Article Published Date
: Feb 08, 2010
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Asthma
Pharmacological Actions
:
Bronchodilator Agents
[+]
Nigella sativa could improve inflammation and reduce oxidative stress in patients with rheumatoid arthritis.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Avicenna J Phytomed. 2016 Jan-Feb;6(1):34-43. PMID:
27247920
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
Nigella sativa enhances memory, attention and cognition in healthy human volunteers.
Jul 29, 2013
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2013 Jul 30 ;148(3):780-6. Epub 2013 May 21. PMID:
23707331
Article Published Date
: Jul 29, 2013
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Cognitive Decline/Dysfunction
,
Memory Disorders
[+]
Nigella sativa may represent a promising intervention for obese prediabetic subjects.
Jun 30, 2021
Click here to read the entire abstract
Pubmed Data
: J Diabetes Complications. 2021 Jul ;35(7):107947. Epub 2021 May 8. PMID:
34006388
Article Published Date
: Jun 30, 2021
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Obesity
,
Prediabetes
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Nigella sativa oil concurrent with a low-calorie diet decreased weight and increased SOD levels in obese women.
Jul 13, 2015
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2015 Jul 14. Epub 2015 Jul 14. PMID:
26179113
Article Published Date
: Jul 13, 2015
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Obesity
,
Oxidative Stress
Therapeutic Actions
:
Dietary Modification: Low Calorie Diet
Pharmacological Actions
:
Antioxidants
,
Superoxide Dismutase Up-regulation
[+]
Nigella sativa oil exerted beneficial effects on glycemic control, serum lipid profile, blood pressure, and body weight among people with T2D.
Jun 16, 2021
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2021 Jun 17. Epub 2021 Jun 17. PMID:
34142392
Article Published Date
: Jun 16, 2021
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Antihypertensive Agents
,
Hypoglycemic Agents
,
Hypolipidemic
[+]
Nigella sativa oil mouth rinse improves chemotherapy-induced oral mucositis in patients with acute myeloid leukemia.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2019 ;2019:3619357. Epub 2019 Oct 30. PMID:
31781612
Article Published Date
: Dec 31, 2018
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Acute Myeloid Leukemia
,
Radiation Induced Illness: Mucositis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Radioprotective
[+]
Nigella sativa oil supplement has cardiovascular protective effects in patients with T2DM.
Jun 07, 2020
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2020 Jun 8. Epub 2020 Jun 8. PMID:
32510754
Article Published Date
: Jun 07, 2020
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
C-Reactive Protein
,
Cardiovascular Diseases
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticholesteremic Agents
,
Antioxidants
,
Cardioprotective
,
Hypoglycemic Agents
,
Hypolipidemic
[+]
Nigella sativa oil supplementation combined with a calorie-restricted diet may modulate systemic inflammatory biomarkers in obese women.
Aug 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Clin Lipidol. 2016 Sep-Oct;10(5):1203-11. Epub 2015 Dec 7. PMID:
27678438
Article Published Date
: Aug 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Inflammation
,
Obesity
Therapeutic Actions
:
Dietary Modification: Low Calorie Diet
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Plant Oils
[+]
Nigella sativa oil supplementation had a protective effect in diabetic nephropathy.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Saudi J Kidney Dis Transpl. 2017 Jan-Feb;28(1):9-14. PMID:
28098097
Article Published Date
: Dec 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Hypoglycemic Agents
[+]
Nigella sativa oil supplementation was associated with faster recovery of symptoms than usual care alone for patients with mild COVID-19 infection.
Aug 14, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Complement Ther Med. 2021 Aug 15 ;61:102769. Epub 2021 Aug 15. PMID:
34407441
Article Published Date
: Aug 14, 2021
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Coronavirus Infection
Pharmacological Actions
:
Immunostimulatory
[+]
Nigella sativa seed oil supplements may decrease the liver enzymes and lipid profiles in the patients with NAFLD.
Nov 30, 2019
Click here to read the entire abstract
Pubmed Data
: J Diabetes Metab Disord. 2019 Dec ;18(2):453-459. Epub 2019 Sep 11. PMID:
31890671
Article Published Date
: Nov 30, 2019
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Nigella sativa seeds can be considered as a therapeutic agent in management of Hashimoto-related metabolic abnormalities.
May 31, 2020
Click here to read the entire abstract
Pubmed Data
: Clin Nutr ESPEN. 2020 Jun ;37:207-212. Epub 2020 Mar 10. PMID:
32359745
Article Published Date
: May 31, 2020
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Endothelial Dysfunction
,
Hashimoto's thyroiditis
Pharmacological Actions
:
Antioxidants
[+]
Nigella sativa seeds powder may be of interest in lowering lipid concentrations in hyperlipidemic subjects.
Mar 14, 2019
Click here to read the entire abstract
Pubmed Data
: Br J Clin Pharmacol. 2019 Mar 15. Epub 2019 Mar 15. PMID:
30875097
Article Published Date
: Mar 14, 2019
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hyperlipidemia
Pharmacological Actions
:
Hypolipidemic
[+]
Nigella sativa seeds showed a decrease in incidence of febrile neutropenia in children with brain tumors undergoing chemotherapy.
Mar 26, 2017
Click here to read the entire abstract
Pubmed Data
: Childs Nerv Syst. 2017 Mar 27. Epub 2017 Mar 27. PMID:
28349493
Article Published Date
: Mar 26, 2017
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemotherapy and Radiation Toxicity
Pharmacological Actions
:
Chemoprotective Agents
Additional Keywords
:
Risk Reduction
,
Significant Treatment Outcome
[+]
Nigella sativa Supplementation Improves Asthma Control and Biomarkers: A Randomized, Double-Blind, Placebo-Controlled Trial.
Jan 16, 2017
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2017 Jan 17. Epub 2017 Jan 17. PMID:
28093815
Article Published Date
: Jan 16, 2017
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Asthma
,
Eosinophilia
Pharmacological Actions
:
anti-inflammatory
Additional Keywords
:
anti-inflammatory
,
Asthma
,
Black Seed
,
Eosinophilia
,
Nigella sativa oil (NSO)
[+]
Novel insight into potential leishmanicidal activities of transdermal patches of Nigella sativa.
Jun 27, 2021
Click here to read the entire abstract
Pubmed Data
: Assay Drug Dev Technol. 2021 Jun 28. Epub 2021 Jun 28. PMID:
34182792
Article Published Date
: Jun 27, 2021
Study Type
: Human Study, In Vitro Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Leishmaniasis
Pharmacological Actions
:
Leishmanicidal
[+]
Oral Nigella sativa oil safely reduces the osteoarthritis symptoms and analgesic dose in the knee osteoarthritis patients.
Sep 16, 2022
Click here to read the entire abstract
Pubmed Data
: Complement Ther Clin Pract. 2022 Sep 17 ;49:101666. Epub 2022 Sep 17. PMID:
36150238
Article Published Date
: Sep 16, 2022
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Osteoarthritis: Knee
Pharmacological Actions
:
Analgesics
Additional Keywords
:
Medication Reduction
[+]
Powdered Nigella sativa has potent beneficial effects in improving thyroid status and anthropometric variables.
Nov 15, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2016 Nov 16 ;16(1):471. Epub 2016 Nov 16. PMID:
27852303
Article Published Date
: Nov 15, 2016
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hashimoto's thyroiditis
Pharmacological Actions
:
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Plant Extracts
[+]
Protective Effects of Nigella sativa on Metabolic Syndrome in Menopausal Women
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Adv Pharm Bull. 2014 ;4(1):29-33. Epub 2013 Dec 23. PMID:
24409406
Article Published Date
: Dec 31, 2013
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Cholesterol: High
,
Cholesterol: LDL/HDL ratio
,
HDL: Low
,
Metabolic Syndrome X
[+]
Supplementation of honey and N. sativa can cause significant symptomatic improvement of patients with functional dyspepsia whom received the standard anti-secretory therapy.
Sep 15, 2015
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2015 Sep 16. Epub 2015 Sep 16. PMID:
26386381
Article Published Date
: Sep 15, 2015
Study Type
: Human Study
Additional Links
Substances
:
Honey
,
Nigella sativa (aka Black Seed)
Diseases
:
Dyspepsia
,
Helicobacter Pylori Infection
[+]
Supplementation with N. Sativa powder may be a beneficial adjunctive therapy in H. pylori-infected patients.
Apr 16, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Med Ther. 2023 Apr 17 ;23(1):123. Epub 2023 Apr 17. PMID:
37069587
Article Published Date
: Apr 16, 2023
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Helicobacter Pylori Infection
[+]
The beneficial health effects of Nigella sativa on Helicobacter pylori eradication, dyspepsia symptoms, and quality of life in infected patients.
Jan 08, 2020
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2020 Jan 9. Epub 2020 Jan 9. PMID:
31916648
Article Published Date
: Jan 08, 2020
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Dyspepsia
,
Helicobacter Pylori Infection
Pharmacological Actions
:
Anti-Bacterial Agents
[+]
The combination of black seeds and turmeric can be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression.
Mar 31, 2015
Click here to read the entire abstract
Pubmed Data
: Complement Ther Med. 2015 Apr ;23(2):165-74. Epub 2015 Jan 14. PMID:
25847554
Article Published Date
: Mar 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Turmeric
Diseases
:
Metabolic Diseases
Pharmacological Actions
:
Antihypertensive Agents
,
Hypoglycemic Agents
,
Hypolipidemic
Additional Keywords
:
Natural Substance Synergy
,
Significant Treatment Outcome
[+]
The daily use of black cumin seeds for 2 months may have a blood pressure-lowering effect in patients with mild hypertension.
Apr 01, 2006
Click here to read the entire abstract
Pubmed Data
: Braz J Med Biol Res. 2006 Apr;39(4):421-9. Epub 2006 Apr 3. PMID:
18705755
Article Published Date
: Apr 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
,
Hypotensive
Additional Keywords
:
Plant Extracts
[+]
The effect of nanomicelle curcumin supplementation and Nigella sativa oil on the expression level of miRNA-21, miRNA-422a, and miRNA-503 gene in postmenopausal women.
Oct 31, 2021
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2021 Nov ;35(11):6216-6227. Epub 2021 Sep 8. PMID:
34496087
Article Published Date
: Oct 31, 2021
Study Type
: Human Study
Additional Links
Substances
:
Curcumin
,
Nigella sativa (aka Black Seed)
Diseases
:
Osteoarthritis
Pharmacological Actions
:
MicroRNA modulator
[+]
The effect of Ni gella sativa and vitamin D3 supplementation on the clinical outcome in COVID-19 patients.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2022 ;13:1011522. Epub 2022 Nov 8. PMID:
36425571
Article Published Date
: Dec 31, 2021
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Vitamin D
Diseases
:
Coronavirus Infection
Pharmacological Actions
:
Antiviral Agents
[+]
The effect of Nigella sativa on appetite, anthropometric and body composition indices among overweight and obese women.
Feb 28, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Complement Ther Med. 2021 Mar ;57:102653. Epub 2020 Dec 25. PMID:
33370571
Article Published Date
: Feb 28, 2021
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
The effect of Nigella sativa supplementation on cardiovascular risk factors in obese and overweight women.
May 31, 2021
Click here to read the entire abstract
Pubmed Data
: Eur J Nutr. 2021 Jun ;60(4):1863-1874. Epub 2020 Sep 2. PMID:
32876804
Article Published Date
: May 31, 2021
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Cardiovascular Diseases
,
Obesity
Pharmacological Actions
:
Antihypertensive Agents
,
Cardioprotective
,
Hypolipidemic
[+]
The fixed oil extracted from Nigella sativa seeds has an in vitro antisickling activity.
Feb 28, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Singapore Med J. 2010 Mar ;51(3):230-4. PMID:
20428745
Article Published Date
: Feb 28, 2010
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Sickle Cell Anemia
Additional Keywords
:
Plant Oils
[+]
The impact of Nigella sativa essential oil on T cells in women with Hashimoto's thyroiditis.
Jun 08, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Antioxidants (Basel). 2023 Jun 9 ;12(6). Epub 2023 Jun 9. PMID:
37371976
Article Published Date
: Jun 08, 2023
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hashimoto's thyroiditis
Pharmacological Actions
:
Immunomodulatory
Additional Keywords
:
Essential Oils
[+]
The results indicate a potential beneficiary effect of Nigella sativa on the metabolic parameters in coronary artery disease patients.
Apr 12, 2021
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2021 Apr 13. Epub 2021 Apr 13. PMID:
33851461
Article Published Date
: Apr 12, 2021
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Coronary Artery Disease
Pharmacological Actions
:
Cardioprotective
[+]
The topical application of Nigella sativa cream was effective and comparable to clobetasol propionate 0.05% gel in the management of OLP.
Dec 21, 2022
Click here to read the entire abstract
Pubmed Data
: Oral Maxillofac Surg. 2022 Dec 22. Epub 2022 Dec 22. PMID:
36547822
Article Published Date
: Dec 21, 2022
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Oral Lichen Planus
Additional Keywords
:
Natural Substances Versus Drugs
[+]
The use of N. sativa nasal spray has symptom reliever effect with no adverse effects in patients.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Allergy Rhinol (Providence). 2018 Jan-Dec;9:2152656718800059. Epub 2018 Oct 4. PMID:
30370173
Article Published Date
: Dec 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Rhinosinusitis
Additional Keywords
:
Significant Treatment Outcome
[+]
The use of N. sativa seeds oil as an adjunct to common medications exhibited additional antihypertensive effects as well as beneficial effects on glucose control and lipid metabolism.
May 05, 2021
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2021 May 6. Epub 2021 May 6. PMID:
33957004
Article Published Date
: May 05, 2021
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
,
Cardioprotective
,
Hypoglycemic Agents
,
Hypolipidemic
[+]
The water extract of black cumin seed has significant anti-epileptic activity in children.
Dec 01, 2007
Click here to read the entire abstract
Pubmed Data
: Med Sci Monit. 2007 Dec;13(12):CR555-9. PMID:
18049435
Article Published Date
: Dec 01, 2007
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Epilepsy: Childhood
[+]
This study gives strength to the potential relevance of Nigella sativa in clinical management of rheumatoid arthritis.
Apr 30, 2016
Click here to read the entire abstract
Pubmed Data
: Immunol Invest. 2016 May ;45(4):271-83. Epub 2016 Apr 21. PMID:
27100726
Article Published Date
: Apr 30, 2016
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
C-Reactive Protein
,
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Immunomodulatory
[+]
Topical application of N. sativa oil is effective in the prevention of chemotherapy-induced phlebitis.
Aug 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomedicine (Taipei). 2019 Sep ;9(3):20. Epub 2019 Aug 27. PMID:
31453801
Article Published Date
: Aug 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemotherapy-Induced Phlebitis (CIP)
Pharmacological Actions
:
Chemoprotective Agents
[+]
Topical application of Nigella sativa oil was effective in reducing pain in patients with knee osteoarthritis.
Oct 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Electron Physician. 2016 Nov ;8(11):3193-3197. Epub 2016 Nov 25. PMID:
28344755
Article Published Date
: Oct 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Osteoarthritis: Knee
Pharmacological Actions
:
Analgesics
[+]
A Nigella sativa extract showed a 88.3% inhibition of proliferation of SiHa human cervical cancer cells and increased the expression of caspase-3, -8 and -9 several-fold
Jan 31, 2013
Click here to read the entire abstract
Pubmed Data
: Nat Prod Commun. 2013 Feb ;8(2):213-6. PMID:
23513732
Article Published Date
: Jan 31, 2013
Study Type
: Human In Vitro
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Caspase-3 Activation
,
Caspase-8 activation
,
Caspase-9 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Plant Extracts
[+]
Black seed, sweet orange, and Anthemis hyalina extracts all exhibit antiviral activity against coronavirus.
Mar 01, 2014
Click here to read the entire abstract
Pubmed Data
: Mol Biol Rep. 2014 Mar ;41(3):1703-11. Epub 2014 Jan 12. PMID:
24413991
Article Published Date
: Mar 01, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Sweet Orange
Diseases
:
Coronavirus Disease
,
Coronavirus Infection
,
Severe Acute Respiratory Syndrome
Pharmacological Actions
:
Antiviral Agents
Additional Keywords
:
Plant Extracts
[+]
N. sativa oil could be used against multi-drug resistant S. aureus in the treatment of diabetic wounds.
Oct 31, 2015
Click here to read the entire abstract
Pubmed Data
: Pak J Pharm Sci. 2015 Nov ;28(6):1985-90. PMID:
26639493
Article Published Date
: Oct 31, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions
:
Anti-Bacterial Agents
Additional Keywords
:
Dose Response
[+]
Nigella sativa has successfully produced inhibition of growth of MCF cell lines with an equivalent potency as that of the standard cisplatin.
Mar 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharmacognosy Res. 2015 Apr-Jun;7(2):193-7. PMID:
25829794
Article Published Date
: Mar 31, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Breast Cancer
,
Liver Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
Additional Keywords
:
Natural Substances Versus Drugs
,
Superiority of Natural Substances versus Drugs
[+]
Thymoquinone-rich fractions of Nigella sativa could be an alternative to combat oxidative stress insults in neurodegenerative diseases.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2016 ;2016:2528935. Epub 2015 Dec 28. PMID:
26823946
Article Published Date
: Dec 31, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Hydrogen Peroxide Induced Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
[+]
Black Seeds medical application and pharmaceutical perspectives.
Dec 31, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Pharm Bioallied Sci. 2023 ;15(2):63-67. Epub 2023 Jun 8. PMID:
37469646
Article Published Date
: Dec 31, 2022
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hyperglycemia
,
Hyperlipidemia
Pharmacological Actions
:
Hypoglycemic Agents
,
Hypolipidemic
[+]
Nigella Sativa Concoction Induced Sustained Seroreversion in HIV Patient.
Dec 31, 2012
Click here to read the entire abstract
Pubmed Data
:
PMID: 24311845
Article Published Date
: Dec 31, 2012
Study Type
: Human: Case Report
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
HIV Infections
Pharmacological Actions
:
Antiviral Agents
,
Immunomodulatory
[+]
Nigella sativa oil Improves motor skill learning.
Dec 31, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2023 ;2023:8498066. Epub 2023 Aug 25. PMID:
37663783
Article Published Date
: Dec 31, 2022
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Neurodegenerative Diseases
Pharmacological Actions
:
Neuroprotective Agents
[+]
Immunomodulatory effects of Nigella sativa seed polysaccharides by gut microbial and proteomic technologies
Jun 21, 2021
Click here to read the entire abstract
Pubmed Data
: Int J Biol Macromol. 2021 Jun 22 ;184:483-496. Epub 2021 Jun 22. PMID:
34166694
Article Published Date
: Jun 21, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Pharmacological Actions
:
Gastrointestinal Agents
,
Immunomodulatory
Additional Keywords
:
Polysaccharides
[+]
"Nigella sativa (black cumin) seed extract alleviates symptoms of allergic diarrhea in mice, involving opioid receptors."
Dec 31, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2012 ;7(6):e39841. Epub 2012 Jun 29. PMID:
22768141
Article Published Date
: Dec 31, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diarrhea
,
Food Allergies
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
A combination of black seeds and turmeric at low doses showed enhanced efficacy in preventing metabolic syndrome in fructose fed rats.
Jan 31, 2015
Click here to read the entire abstract
Pubmed Data
: J Cardiovasc Pharmacol. 2015 Feb ;65(2):176-83. PMID:
25384193
Article Published Date
: Jan 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Turmeric
Diseases
:
Dyslipidemias
,
Endothelial Dysfunction
,
Fructose-Induced Toxicity
,
Hyperglycemia
,
Hyperinsulinism
,
Hypertension
,
Metabolic Diseases
Pharmacological Actions
:
Anticholesteremic Agents
,
Antihypertensive Agents
,
Hypoglycemic Agents
,
Hypolipidemic
Additional Keywords
:
Natural Substance Synergy
,
Risk Reduction
[+]
A hydro-alcoholic extract of nigella sativa reduced the LPS-induced sickness behaviors in rats.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Avicenna J Phytomed. 2016 Jan-Feb;6(1):104-16. PMID:
27247927
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Lipopolysaccharide-Induced Toxicity
Additional Keywords
:
Plant Extracts
[+]
A hydroalcoholic extract of the Nigella sativa decreased oxidative stress in hippocampus of the STZ-induced diabetic rats.
Jun 30, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Avicenna J Phytomed. 2015 Jul-Aug;5(4):333-40. PMID:
26445713
Article Published Date
: Jun 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Brain: Oxidative Stress
,
Diabetic Complications
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Plant Extracts
[+]
A liposomal preparation of black seed oil demonstrated significant analgesic activity in mice.
Feb 28, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Saudi Pharm J. 2017 Mar ;25(3):404-412. Epub 2016 Oct 1. PMID:
28344496
Article Published Date
: Feb 28, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chronic Pain
Pharmacological Actions
:
Analgesics
Additional Keywords
:
Liposomal
[+]
A mechanistic insight into the potential anti-cancerous property of Nigella sativa on breast cancer.
Aug 31, 2023
Click here to read the entire abstract
Pubmed Data
: Fitoterapia. 2023 Sep ;169:105601. Epub 2023 Jul 3. PMID:
37406886
Article Published Date
: Aug 31, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anti-Apoptotic
,
MicroRNA modulator
Additional Keywords
:
Plant Extracts
[+]
A plant mixture comprising Nigella sativa, Myrrh, Gum Olibanum (Frankincense), Gum Asafoetida and Aloe lowers blood sugar by inhibiting hepatis gluconeogenesis.
Dec 01, 1991
Click here to read the entire abstract
Pubmed Data
: Diabetes Res. 1991 Dec;18(4):163-8. PMID:
1842751
Article Published Date
: Dec 01, 1991
Study Type
: Animal Study
Additional Links
Substances
:
Aloe Vera
,
Asafoetida
,
Frankincense
,
Myrrh
,
Nigella sativa (aka Black Seed)
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Gluconeogenesis Inhibitor
Additional Keywords
:
Plant Extracts
[+]
A study of antibacterial effect of Nigella sativa seed extracts on bacterial isolates from cases of wound infection.
Apr 02, 2023
Click here to read the entire abstract
Pubmed Data
: Infect Disord Drug Targets. 2023 Apr 3. Epub 2023 Apr 3. PMID:
37016531
Article Published Date
: Apr 02, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Methicillin-resistant Staphylococcus aureus
,
Wound Healing
Pharmacological Actions
:
Anti-Bacterial Agents
[+]
A thymoquinone-rich fraction extracted from Nigella sativa effectively improved the plasma and liver antioxidant capacity.
Feb 28, 2010
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2010 Mar 1 ;48(5):664-72. Epub 2009 Dec 11. PMID:
20005291
Article Published Date
: Feb 28, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hypercholesterolemia
Pharmacological Actions
:
Antioxidants
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Gene Expression Regulation
[+]
Active components in Nigella sativa and Olive oil may prove useful in treating impaired cognition.
Nov 20, 2016
Click here to read the entire abstract
Pubmed Data
: Nutr Neurosci. 2016 Nov 21:1-10. Epub 2016 Nov 21. PMID:
27868798
Article Published Date
: Nov 20, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Olive Oil
Diseases
:
Cognitive Decline/Dysfunction
Pharmacological Actions
:
Neuroprotective Agents
[+]
Administration of either nigella sativa oil counteracts dexamethasone induced-gastric lesions.
Feb 09, 2017
Click here to read the entire abstract
Pubmed Data
: Can J Physiol Pharmacol. 2017 Feb 10. Epub 2017 Feb 10. PMID:
28187265
Article Published Date
: Feb 09, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Corticosteroid-Induced Toxicity
Pharmacological Actions
:
Anti-Ulcer Agents
,
Gastroprotective
,
Malondialdehyde Down-regulation
[+]
Administration of melatonin, retinoic acid and Nigella sativa reduced the carcinogenic effects of DMBA.
Nov 30, 2005
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Exp Pathol. 2005 Dec ;86(6):383-96. PMID:
16309544
Article Published Date
: Nov 30, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Nigella sativa (aka Black Seed)
,
Vitamin A
Diseases
:
Breast Cancer
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Anticarcinogenic Agents
Additional Keywords
:
Metabolites
,
Phytotherapy
,
Plant Extracts
[+]
Administration of Nigella sativa can be used to prevent formaldehyde induced apoptosis and epithelial damage.
Apr 30, 2017
Click here to read the entire abstract
Pubmed Data
: Niger J Clin Pract. 2017 May ;20(5):523-529. PMID:
28513508
Article Published Date
: Apr 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Formaldehyde Toxicity
Pharmacological Actions
:
Anti-Apoptotic
,
Cytoprotective
Problem Substances
:
Formaldehyde
[+]
Administration of Nigella sativa seed oil exerts a protective effect against urolithiasis.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Afr J Tradit Complement Altern Med. 2016 ;13(6):204-214. Epub 2016 Sep 29. PMID:
28480381
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Urolithiasis
[+]
Ameliorative effect of Nigella sativa oil and vitamin C on the thyroid gland and cerebellum.
Sep 30, 2020
Click here to read the entire abstract
Pubmed Data
: Tissue Cell. 2020 Oct ;66:101391. Epub 2020 Jun 8. PMID:
32933714
Article Published Date
: Sep 30, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Vitamin C
Diseases
:
Thyroid Diseases
Pharmacological Actions
:
Neuroprotective Agents
[+]
Antimalarial activity of Nigella sativa seed extracts.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Pathog. 2021 ;2021:6165950. Epub 2021 Feb 3. PMID:
33623718
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Malaria
Pharmacological Actions
:
Antimalarials
[+]
Antioxidant and cytoprotective effects of Nigella sativa L. seeds on the testis of monosodium glutamate challenged rats.
Jun 28, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2021 Jun 29 ;11(1):13519. Epub 2021 Jun 29. PMID:
34188150
Article Published Date
: Jun 28, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Antioxidants
,
Cytoprotective
Problem Substances
:
Monosodium Glutamate (MSG)
[+]
Black cumin exhibit significant antifungal activity against candidasis in mice.
Feb 01, 2003
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2003 Feb;17(2):183-6. PMID:
12601685
Article Published Date
: Feb 01, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Candidiasis
,
Fungal Infection
Pharmacological Actions
:
Antifungal Agents
Additional Keywords
:
Plant Extracts
[+]
Black cumin extract reduces the damage caused by cadmium poisoning in rats.
May 01, 2006
Click here to read the entire abstract
Pubmed Data
: Biol Trace Elem Res. 2006 May;110(2):151-62. PMID:
16757843
Article Published Date
: May 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Cadmium Poisoning
[+]
Black Cumin improves blood lipid profiles.
Oct 04, 2010
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2010 Oct 4;482(3):183-7. Epub 2010 Jun 11. PMID:
16092657
Article Published Date
: Oct 04, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Cholesterol: LDL/HDL ratio
,
HDL: Low
,
High Cholesterol
[+]
Black cumin may have antidiabetic effects by increasing insulin sensitivity.
Jan 01, 2011
Click here to read the entire abstract
Pubmed Data
: Evid Based Complement Alternat Med. 2011;2011:538671. Epub 2011 Apr 14. PMID:
21584245
Article Published Date
: Jan 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetes Mellitus: Type 2
,
Insulin Resistance
Pharmacological Actions
:
Insulin Sensitizers
[+]
Black cumin oil decreased the proinflammatory cytokines, lactate dehydrogenase, triglyceride, and cholesterol, which were increased in colitis.
Feb 28, 2011
Click here to read the entire abstract
Pubmed Data
: Dig Dis Sci. 2011 Mar ;56(3):721-30. Epub 2010 Jul 24. PMID:
20658190
Article Published Date
: Feb 28, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Oxidative Stress
,
Ulcerative Colitis
Pharmacological Actions
:
Antioxidants
,
Hypolipidemic
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Malondialdehyde Down-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Oils
[+]
Black cumin protects against chemical weapon agent induced lung injury.
May 01, 2008
Click here to read the entire abstract
Pubmed Data
: Exp Lung Res. 2008 May;34(4):183-94. PMID:
18432455
Article Published Date
: May 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemical Weapon Agent Injury
Additional Keywords
:
Plant Extracts
[+]
Black cumin seed oil has significant protective activity against cytomegalovirus infection in the mouse experimental model.
Sep 01, 2000
Click here to read the entire abstract
Pubmed Data
: Int J Immunopharmacol. 2000 Sep;22(9):729-40. PMID:
10884593
Article Published Date
: Sep 01, 2000
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Cytomegalovirus Infections
Pharmacological Actions
:
Antiviral Agents
,
Interferon Inducers
[+]
Black cumin's hyperglycemic activity in the rat model of diabetes may be due to beta cell regeneration/proliferation.
Dec 01, 2003
Click here to read the entire abstract
Pubmed Data
: Tohoku J Exp Med. 2003 Dec;201(4):213-9. PMID:
14690013
Article Published Date
: Dec 01, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetes Mellitus: Type 1
Additional Keywords
:
Beta Cell Regeneration
[+]
Black seed oil exhibited an anti-aging effect in a model of aging induced with D-galactose.
Feb 28, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Pharmacopuncture. 2017 Mar ;20(1):29-35. PMID:
28392960
Article Published Date
: Feb 28, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Aging
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
[+]
Black seed oil has significant inhibitory effects against colon cancer in rats, without observable side effects.
Jan 01, 2003
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2003;45(2):195-202. PMID:
12881014
Article Published Date
: Jan 01, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
[+]
Black seed thymoquinone improved insulin secretion, hepatic glycogen storage, and oxidative stress in streptozotocin-induced diabetic male wistar rats.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2018 ;2018:8104165. Epub 2018 Mar 4. PMID:
29686746
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Diabetes: Oxidative Stress
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Antioxidants
,
Insulin-releasing
[+]
Bone marrow-derived mesenchymal stem cells and N.sativa ameliorate the histological, biochemical and immunohistochemical changes induced by energy drink.
Jun 30, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Folia Morphol (Warsz). 2019 Jul 1. Epub 2019 Jul 1. PMID:
31257565
Article Published Date
: Jun 30, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Pharmacological Actions
:
Pancreato Protective Agents
Additional Keywords
:
Mesenchymal Stem Cells
Problem Substances
:
Energy Drinks
[+]
Both Nigella sativa and date reduce the toxic effects of aflatoxin-B1 in liver and kidney.
Jun 30, 2008
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Health Sci (Qassim). 2008 Jul ;2(2):26-44. PMID:
21475486
Article Published Date
: Jun 30, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Dates
,
Nigella sativa (aka Black Seed)
Diseases
:
Liver Damage: Aflatoxin-Induced
Pharmacological Actions
:
Hepatoprotective
,
Renoprotective
Problem Substances
:
Aflatoxin
[+]
Both Nigella sativa and thymoquinone can partly protect gastric mucosa from acute alcohol-induced mucosal injury.
Nov 13, 2005
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: World J Gastroenterol. 2005 Nov 14 ;11(42):6662-6. PMID:
16425361
Article Published Date
: Nov 13, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Alcohol Toxicity
Pharmacological Actions
:
Gastroprotective
,
Malondialdehyde Down-regulation
,
Superoxide Dismutase Up-regulation
[+]
Both Nigella sativa fixed and essential oil are effective in improving the antioxidant indices against potassium bromate induced oxidative stress.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2015 ;15(1):330. Epub 2015 Sep 18. PMID:
26385559
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Essential Oils
[+]
Both Nigella sativa oil and thymoquinone possess gastroprotective effect against gastric lesions.
Jan 31, 2003
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2003 Feb ;84(2-3):251-8. PMID:
12648823
Article Published Date
: Jan 31, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Ischemia
,
Lipid Peroxidation
Pharmacological Actions
:
Anti-Ulcer Agents
,
Gastroprotective
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Plant Oils
[+]
Chondroprotective effect of Nigella sativa oil in the early stages of osteoarthritis.
Aug 31, 2019
Click here to read the entire abstract
Pubmed Data
: J Musculoskelet Neuronal Interact. 2019 Sep 1 ;19(3):362-369. PMID:
31475944
Article Published Date
: Aug 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Chondroprotective
[+]
Chronic administration of N. sativa seed extract has a significant hypoglycemic effect.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Avicenna J Phytomed. 2016 Jan-Feb;6(1):67-76. PMID:
27247923
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetic Complications
,
Endothelial Dysfunction
Pharmacological Actions
:
Hypoglycemic Agents
[+]
Cold-pressed Nigella Sativa oil standardized to 3% thymoquinone potentiates omega-3 protection against obesity.
Jun 03, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Antioxidants (Basel). 2020 Jun 4 ;9(6). Epub 2020 Jun 4. PMID:
32512788
Article Published Date
: Jun 03, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Omega-3 Fatty Acids
,
Thymoquinone
Diseases
:
Insulin Resistance
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Anti-Obesity Agents
[+]
Comparative hepatoprotective effect of Nigella sativa pre- and post-treatment.
Dec 31, 2018
Click here to read the entire abstract
Pubmed Data
: Pak J Pharm Sci. 2019 Jan ;32(1):205-212. PMID:
30772810
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Chemically-Induced Liver Damage
Pharmacological Actions
:
Hepatoprotective
,
Prophylactic Agents
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Covering peritoneal surfaces with nigella sativa oil after peritoneal trauma is effective in decreasing peritoneal adhesion formation.
Oct 06, 2013
Click here to read the entire abstract
Pubmed Data
:
J Obstet Gynaecol Res.
2013 Oct 7. doi: 10.1111/jog.12172.
Article Published Date
: Oct 06, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Abdominal Adhesions
[+]
Curcuma xanthorriza, black cumin seed, and honey preparations display chemopreventive, antioxidant, and immunomodulatory properties.
Jan 10, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2023 Jan 11 ;15(2). Epub 2023 Jan 11. PMID:
36678242
Article Published Date
: Jan 10, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Honey
,
Nigella sativa (aka Black Seed)
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antioxidants
,
Chemopreventive
,
Immunomodulatory
[+]
Effect of Allium sativum and Nigella sativa on alleviating aluminum toxicity.
Dec 31, 2021
Click here to read the entire abstract
Pubmed Data
: Front Vet Sci. 2022 ;9:1042640. Epub 2022 Nov 29. PMID:
36524230
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Garlic
,
Nigella sativa (aka Black Seed)
Diseases
:
Aluminum Toxicity
,
Chemically-Induced Liver Damage
,
Kidney Damage: Chemically-Induced
,
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Hepatoprotective
,
Renoprotective
Problem Substances
:
Aluminum
[+]
Effect of black seeds on inflammatory and immunomodulatory markers in Plasmodium berghei.
Jul 13, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Food Biochem. 2022 Jul 14:e14300. Epub 2022 Jul 14. PMID:
35833536
Article Published Date
: Jul 13, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Malaria
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Immunomodulatory
,
Interleukin-10 upregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Effects of Nigella sativa and human parathyroid hormone on bone mass and strength in diabetic rats.
May 31, 2007
Click here to read the entire abstract
Pubmed Data
: Biol Trace Elem Res. 2007 Jun ;116(3):321-8. PMID:
17709912
Article Published Date
: May 31, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetic Complications
,
Osteoporosis
Pharmacological Actions
:
Osteoprotective
Additional Keywords
:
Plant Extracts
[+]
Effects of Nigella sativa oil and thymoquinone against bisphenol A-induced metabolic disorder.
Dec 13, 2020
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2020 Dec 14. Epub 2020 Dec 14. PMID:
33315269
Article Published Date
: Dec 13, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Bisphenol Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antihypertensive Agents
,
Antioxidants
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances
:
Bisphenol A
[+]
Effects of Nigella sativa oil and thymoquinone on radiation-induced oxidative stress in kidney tissue.
Apr 04, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Pharmacother. 2021 Apr 5 ;139:111540. Epub 2021 Apr 5. PMID:
33831837
Article Published Date
: Apr 04, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Oxidative Stress
,
Radiation
Pharmacological Actions
:
Antioxidants
,
Radioprotective
[+]
Effects of Nigella sativa seed polysaccharides on type 2 diabetic mice and gut microbiota.
May 07, 2020
Click here to read the entire abstract
Pubmed Data
: Int J Biol Macromol. 2020 May 8 ;159:725-738. Epub 2020 May 8. PMID:
32437806
Article Published Date
: May 07, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Gastrointestinal Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Polysaccharides
[+]
Efficient therapeutic effect of Nigella sativa aqueous extract and chitosan nanoparticles against experimentally induced acanthamoeba keratitis.
May 28, 2019
Click here to read the entire abstract
Pubmed Data
: Parasitol Res. 2019 May 29. Epub 2019 May 29. PMID:
31144032
Article Published Date
: May 28, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Keratitis
Additional Keywords
:
Significant Treatment Outcome
[+]
Enhanced antinociceptive activity of Nigella sativa oil after its combined treatment with honey in rats.
Dec 31, 2021
Click here to read the entire abstract
Pubmed Data
: Pak J Pharm Sci. 2022 Jan ;35(1):1-8. PMID:
35221265
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Honey
,
Nigella sativa (aka Black Seed)
Diseases
:
Chronic Pain
Pharmacological Actions
:
Antinoceceptive
[+]
Ethanolic extract of Nigella sativa possessed significant analgesic effect in mice.
Jun 30, 2010
Click here to read the entire abstract
Pubmed Data
: J Coll Physicians Surg Pak. 2010 Jul ;20(7):464-7. PMID:
20642947
Article Published Date
: Jun 30, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chronic Pain
Pharmacological Actions
:
Analgesics
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Evaluation of the antidepressant-like effect of chronic administration of Nigella fixed oil versus fluoxetine.
Nov 30, 2021
Click here to read the entire abstract
Pubmed Data
: CNS Neurol Disord Drug Targets. 2021 Dec 1. Epub 2021 Dec 1. PMID:
34852753
Article Published Date
: Nov 30, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
Additional Keywords
:
Natural Substances Versus Drugs
[+]
Feeding of Nigella sativa during neonatal and juvenile growth improves learning and memory of rats.
Mar 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Tradit Complement Med. 2016 Apr ;6(2):146-52. Epub 2015 Jan 17. PMID:
27114937
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Learning disorders
,
Memory Disorders
Pharmacological Actions
:
Antioxidants
[+]
Fish oil and Nigella sative volatile oil emulsion had promising hepato-regenerative and reno-protective abilities.
Feb 18, 2018
Click here to read the entire abstract
Pubmed Data
: J Oleo Sci. 2018 Feb 19. Epub 2018 Feb 19. PMID:
29459508
Article Published Date
: Feb 18, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Fish Oil
,
Nigella sativa (aka Black Seed)
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Hepatoprotective
,
Renoprotective
Additional Keywords
:
Liver Regeneration
[+]
Garlic extract and Nigella sativa oil are promising agents to complement schistosomiasis specific treatment.
Dec 31, 2007
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Article Publish Status
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Pubmed Data
: Rev Inst Med Trop Sao Paulo. 2008 Jan-Feb;50(1):29-36. PMID:
18327484
Article Published Date
: Dec 31, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Garlic
,
Nigella sativa (aka Black Seed)
Diseases
:
Lipid Peroxidation
,
Schistosomiasis
Pharmacological Actions
:
Antioxidants
,
Antiparasitic Agents
Additional Keywords
:
Plant Extracts
[+]
Grape seed extract, black seed extract and curcumin ameliorate tamoxifen-induced liver injury.
Jan 01, 2007
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Pubmed Data
: Hepatogastroenterology. 2007 Jan-Feb;54(73):320-4. PMID:
21046982
Article Published Date
: Jan 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Grape Seed Extract
,
Nigella sativa (aka Black Seed)
Diseases
:
Chemically-Induced Liver Damage
,
Chemotherapy-Induced Toxicity: Tamoxifen
,
Drug-Induced Toxicity
Pharmacological Actions
:
Hepatoprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Drug: Tamoxifen
,
Plant Extracts
[+]
Hexane extracts of N. sativa have a protective and therapeutic role in the oxidative stress, caused by high-fat diets.
Dec 31, 2017
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Article Publish Status
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Pubmed Data
: Adv Biomed Res. 2018 ;7:121. Epub 2018 Aug 29. PMID:
30211134
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
High Fat Diet
,
Obesity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Anti-Obesity Agents
[+]
Hydro-alcoholic extracts of N.sativa and C.longa led to an improvement in ADR-induced oxidative stress.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Avicenna J Phytomed. 2016 Jan-Feb;6(1):86-94. PMID:
27247925
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Turmeric
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Antioxidants
,
Chemoprotective Agents
Problem Substances
:
Doxorubicin
[+]
In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa.
Feb 22, 2018
Click here to read the entire abstract
Pubmed Data
: Turk J Med Sci. 2018 Feb 23 ;48(1):178-186. Epub 2018 Feb 23. PMID:
29479981
Article Published Date
: Feb 22, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Liver Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Inhibitory effects of Nigella sativa seed oil on the testosterone-induced benign prostatic hyperplasia in rats.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
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Pubmed Data
: Biomedicine (Taipei). 2021 ;11(1):19-25. Epub 2021 Mar 1. PMID:
35223391
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Prostatic Hyperplasia: Benign
Pharmacological Actions
:
Antioxidants
[+]
Intratympanic nigella sativa oil protects against gentamicin induced hearing loss.
May 31, 2017
Click here to read the entire abstract
Pubmed Data
: Int J Pediatr Otorhinolaryngol. 2017 Jun ;97:83-88. Epub 2017 Mar 30. PMID:
28483257
Article Published Date
: May 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions
:
Chemoprotective Agents
[+]
Investigation of the protective effect of Nigella sativa oil in cisplatin induced oral mucositis.
Feb 29, 2020
Click here to read the entire abstract
Pubmed Data
: Turk Arch Otorhinolaryngol. 2020 Mar ;58(1):10-15. Epub 2019 Sep 2. PMID:
32313889
Article Published Date
: Feb 29, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
,
Oral Mucositis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Chemoprotective Agents
[+]
Memory enhancing effect of Nigella Sativa hydro-alcoholic extract on lipopolysaccharide-induced memory impairment.
Mar 27, 2018
Click here to read the entire abstract
Pubmed Data
: Drug Chem Toxicol. 2018 Mar 28:1-10. Epub 2018 Mar 28. PMID:
29589766
Article Published Date
: Mar 27, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Cognitive Decline/Dysfunction
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Antioxidants
,
Malondialdehyde Down-regulation
,
Neuroprotective Agents
,
Nitric Oxide Inhibitor
[+]
Methanolic extracts and volatile oil extracts of N. sativa seed oil may be used as antioxidant as well as hypolipidemic agents
Dec 17, 2015
Click here to read the entire abstract
Pubmed Data
: Nutrition. 2015 Dec 18. Epub 2015 Dec 18. PMID:
26827238
Article Published Date
: Dec 17, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Linoleic acid
,
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Hyperlipidemia
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Hypolipidemic
Additional Keywords
:
Plant Extracts
,
Plant Oils
[+]
Molecular mechanisms of Nigella sativa- and Nigella sativa exercise-induced cardiac hypertrophy in rats.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Evid Based Complement Alternat Med. 2021 ;2021:5553022. Epub 2021 Apr 9. PMID:
34055008
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Cardiac Hypertrophy
Therapeutic Actions
:
Exercise
Pharmacological Actions
:
Cardioprotective
[+]
N sativa may protect brain and medulla spinalis tissues against oxidative stress induced by experimental autoimmune encephalomyelitis.
Sep 04, 2005
Click here to read the entire abstract
Pubmed Data
: Cell Mol Biol (Noisy-le-grand). 2005 Sep 5 ;51(3):337-42. Epub 2005 Sep 5. PMID:
16191402
Article Published Date
: Sep 04, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Encephalomyelitis
,
Multiple Sclerosis
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Malondialdehyde Down-regulation
,
Superoxide Dismutase Up-regulation
[+]
N. sativa administration exerts potent inhibitory effects on rat tumor development and on cellular proliferation in multiple organ sites.
Aug 31, 2010
Click here to read the entire abstract
Article Publish Status
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Pubmed Data
: Oncol Lett. 2010 Sep ;1(5):913-924. Epub 2010 Sep 1. PMID:
22966405
Article Published Date
: Aug 31, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Colon Cancer
,
Lung Cancer
,
Stomach Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
[+]
N. sativa and propolis could be excellent adjuvant support in the therapy of diabetes mellitus and preventing its complications.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Evid Based Complement Alternat Med. 2017 ;2017:5439645. Epub 2017 Feb 16. PMID:
28298934
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Bee Propolis
,
Nigella sativa (aka Black Seed)
Diseases
:
Diabetic Complications
,
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Renoprotective
[+]
N. sativa and thymoquinone may prove clinically useful in the treatment of diabetics and in the protection of β-cells against oxidative stress.
Nov 30, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: J Diabetes. 2010 Dec ;2(4):256-66. PMID:
20923501
Article Published Date
: Nov 30, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Diabetes: Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Malondialdehyde Down-regulation
,
Pancreato Protective Agents
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Antioxidants
,
Diabetes: Oxidative Stress
,
Nigella sativa (aka Black Seed)
,
Phytotherapy
,
Plant Extracts
,
thymoquinone
[+]
N. sativa contains potent bioactive components that may aid in treatment against cisplatin induced renal toxicity.
Jul 02, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Ital J Food Saf. 2018 Jul 3 ;2(7):7242. Epub 2018 Jul 3. PMID:
30046560
Article Published Date
: Jul 02, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Chemoprotective Agents
[+]
N. sativa could be considered as a potential therapy for asthma therapy and prevention.
Oct 18, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: BMC Res Notes. 2018 Oct 19 ;11(1):744. Epub 2018 Oct 19. PMID:
30340634
Article Published Date
: Oct 18, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Asthma
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
N. sativa could be used in the treatment of rhinosinusitis diseases.
Jan 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Acta Otorhinolaryngol Ital. 2017 Feb ;37(1):32-37. PMID:
28374868
Article Published Date
: Jan 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Rhinosinusitis
Pharmacological Actions
:
Nitric Oxide Inhibitor
[+]
N. sativa exerts a protective effect against cadmium toxicity.
Nov 30, 2005
Click here to read the entire abstract
Pubmed Data
: Biol Trace Elem Res. 2005 Dec ;107(3):277-87. PMID:
16286683
Article Published Date
: Nov 30, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Cadmium Poisoning
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Malondialdehyde Down-regulation
,
Superoxide Dismutase Up-regulation
[+]
N. sativa extract and vitamin E improved the serum and urine biochemical parameters and kidney function in cisplatin-induced nephrotoxicity.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Avicenna J Phytomed. 2016 Jan-Feb;6(1):44-54. PMID:
27247921
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Vitamin E
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Chemoprotective Agents
,
Renoprotective
[+]
N. sativa extract has potential to prevent the hippocampal neural damage after inducing hypothyroidism during neonatal and juvenile growth in rats.
May 10, 2017
Click here to read the entire abstract
Pubmed Data
: Metab Brain Dis. 2017 May 11. Epub 2017 May 11. PMID:
28497360
Article Published Date
: May 10, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hypothyroidism
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Plant Extracts
[+]
N. Sativa extract is effective for early and late prevention of pulmonary fibrosis and inflammation.
Apr 30, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Avicenna J Phytomed. 2018 May-Jun;8(3):263-275. PMID:
29881712
Article Published Date
: Apr 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions
:
Anti-Fibrotic
[+]
N. sativa extract significantly promoted wound healing in diabetic rats.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Int J Prev Med. 2019 ;10:18. Epub 2019 Feb 12. PMID:
30820305
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Wound Healing
[+]
N. sativa may be used to minimize the risk of diabetic microangiopathy.
Apr 30, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharmacogn Mag. 2016 May ;12(Suppl 2):S175-80. Epub 2016 May 11. PMID:
27279704
Article Published Date
: Apr 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetic Microangiopathy
Pharmacological Actions
:
Hypoglycemic Agents
Additional Keywords
:
Risk Reduction
[+]
N. sativa may be useful in ameliorating signs of gentamicin nephrotoxicity in rats.
Dec 31, 2003
Click here to read the entire abstract
Pubmed Data
: Am J Chin Med. 2004 ;32(1):49-55. PMID:
15154284
Article Published Date
: Dec 31, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions
:
Chemoprotective Agents
Additional Keywords
:
Phytotherapy
[+]
N. sativa oil is a useful choice for the treatment of anxiety.
Mar 31, 2009
Click here to read the entire abstract
Pubmed Data
: Pak J Pharm Sci. 2009 Apr ;22(2):139-44. PMID:
19339222
Article Published Date
: Mar 31, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Anxiety
Pharmacological Actions
:
Anti-Anxiety Agents
Additional Keywords
:
Plant Oils
[+]
N. sativa oil may be useful for reducing blood glucose levels and elevated oxidant activity in diabetic patients.
Feb 28, 2019
Click here to read the entire abstract
Pubmed Data
: Biotech Histochem. 2019 Mar 1:1-9. Epub 2019 Mar 1. PMID:
30821520
Article Published Date
: Feb 28, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetes: Oxidative Stress
,
Hyperglycemia
Pharmacological Actions
:
Antioxidants
,
Hypoglycemic Agents
[+]
N. sativa oil modulates the proinflammatory actions of human ASM cells by inhibiting the production of GC-insensitive chemokines.
May 29, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Plants (Basel). 2023 May 30 ;12(11). Epub 2023 May 30. PMID:
37299150
Article Published Date
: May 29, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Asthma
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interferon Gamma Reducer
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
N. sativa seed has antidiabetic and antihyperlipidemic properties and improved vasoreactivity, endothelial dysfunction, and vascular inflammation.
Jan 09, 2019
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2019 Jan 10 ;228:142-147. Epub 2018 Sep 14. PMID:
30223051
Article Published Date
: Jan 09, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetic Complications
,
Endothelial Dysfunction
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hypolipidemic
[+]
N. sativa seeds and its active ingredient, thymoquinone have a protective effect against streptozotocin-induced diabetes.
Dec 20, 2022
Click here to read the entire abstract
Pubmed Data
: Cardiovasc Hematol Agents Med Chem. 2022 Dec 21. Epub 2022 Dec 21. PMID:
36545735
Article Published Date
: Dec 20, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypoglycemic Agents
,
Hypolipidemic
[+]
N. sativa seeds appeared to be safe and possibly protective against carbon tetrachloride induced hepatotoxicity.
Dec 31, 2002
Click here to read the entire abstract
Pubmed Data
: Am J Chin Med. 2003 ;31(5):721-8. PMID:
14696675
Article Published Date
: Dec 31, 2002
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
Additional Keywords
:
Phytotherapy
,
Plant Oils
[+]
N. sativa treatment ameliorated the pentylenetetrazol induced neurodegeneration in the cerebral cortex.
Oct 31, 2016
Click here to read the entire abstract
Pubmed Data
: Biotech Histochem. 2016 Nov ;91(8):493-500. PMID:
27849392
Article Published Date
: Oct 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Neurodegenerative Diseases
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Nigella saliva seeds can protect against lead acetate induced hepatic oxidative damage.
Mar 02, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Mar 3 ;89:711-718. Epub 2017 Mar 3. PMID:
28273633
Article Published Date
: Mar 02, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Lead Poisoning
,
Oxidative Stress
Pharmacological Actions
:
Hepatoprotective
Problem Substances
:
Lead
[+]
Nigella sativa stimulate insulin secretion from isolated rat islets and inhibit the digestion and absorption of (CH2O)n in the gut.
Aug 01, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biosci Rep. 2019 Aug 2. Epub 2019 Aug 2. PMID:
31375555
Article Published Date
: Aug 01, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Hypoglycemic Agents
,
Insulin-releasing
[+]
Nigella sativa (black cumin) and Syzygium aromaticum (clove) protect against aflatoxicosis in rats.
May 01, 2005
Click here to read the entire abstract
Pubmed Data
: J Appl Toxicol. 2005 May-Jun;25(3):218-23. PMID:
15856529
Article Published Date
: May 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Clove
,
Nigella sativa (aka Black Seed)
Diseases
:
Aflatoxicosis
Pharmacological Actions
:
Antioxidants
[+]
Nigella sativa (black cumin) protects against chronic antiretroviral therapy-associated insulin resistance in HIV-1 infected rats.
Apr 01, 2009
Click here to read the entire abstract
Pubmed Data
: Can J Physiol Pharmacol. 2009 Apr;87(4):300-9. PMID:
19370083
Article Published Date
: Apr 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
HIV Drug-Induced Toxicity
,
Hyperinsulinism
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Drug Side Effect Attenuation
[+]
Nigella sativa acts in the kidney as a potent scavenger of free radicals to prevent the toxic effects of gentamicin.
Feb 28, 2010
Click here to read the entire abstract
Pubmed Data
: Exp Toxicol Pathol. 2010 Mar ;62(2):183-90. Epub 2009 Apr 23. PMID:
19398313
Article Published Date
: Feb 28, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions
:
Chemoprotective Agents
Additional Keywords
:
Phytotherapy
[+]
Nigella sativa and its main constituent, thymoquinone protect against glycerol-induced acute kidney injury.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Avicenna J Phytomed. 2022 ;12(6):638-648. PMID:
36583174
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Kidney Damage
Pharmacological Actions
:
Renoprotective
[+]
Nigella sativa and nettle decrease lipid peroxidation and liver enzymes, and increase the antioxidant defence system activity in CCl4-treated rats.
May 31, 2003
Click here to read the entire abstract
Pubmed Data
: J Vet Med A Physiol Pathol Clin Med. 2003 Jun ;50(5):264-8. PMID:
14567515
Article Published Date
: May 31, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Nettle
,
Nigella sativa (aka Black Seed)
Diseases
:
Chemically-Induced Liver Damage
,
Lipid Peroxidation
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
Additional Keywords
:
Phytotherapy
,
Plant Oils
[+]
Nigella sativa and onion extract attenuate the pathological effect of nicotine in the lung.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Folia Morphol (Warsz). 2019 ;78(3):554-563. Epub 2018 Dec 21. PMID:
30575005
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Onion
Diseases
:
Lung Injury: Smoke-Induced
,
Nicotine/Tobacco Toxicity
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Plant Extracts
[+]
Nigella sativa and thymoquinone attenuate oxidative stress and cognitive impairment following cerebral hypoperfusion in rats.
Apr 22, 2019
Click here to read the entire abstract
Pubmed Data
: Metab Brain Dis. 2019 Apr 23. Epub 2019 Apr 23. PMID:
31016464
Article Published Date
: Apr 22, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Cerebral Hypoperfusion
,
Dementia
Pharmacological Actions
:
Neuroprotective Agents
[+]
Nigella sativa and thymoquinone could be a potential treatment against peripheral neuropathy.
Dec 31, 2007
Click here to read the entire abstract
Pubmed Data
: Neurochem Res. 2008 Jan ;33(1):87-96. Epub 2007 Aug 23. PMID:
17713854
Article Published Date
: Dec 31, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Diabetic Neuropathy
Pharmacological Actions
:
Neuroprotective Agents
[+]
Nigella sativa could be efficacious against organophosphate induced oxidative damage.
Jun 29, 2018
Click here to read the entire abstract
Pubmed Data
: Niger J Physiol Sci. 2018 Jun 30 ;33(1):83-88. Epub 2018 Jun 30. PMID:
30091737
Article Published Date
: Jun 29, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Brain: Oxidative Stress
,
Lipid Peroxidation
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
Problem Substances
:
Dichlorvos
,
Organophosphates
[+]
Nigella sativa could reduce the chances of hypothyroidism induced gastritis.
Mar 09, 2009
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Physiol Pathophysiol Pharmacol. 2009 Mar 10 ;1(2):143-149. Epub 2009 Mar 10. PMID:
21383883
Article Published Date
: Mar 09, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Gastritis
,
Hypothyroidism
Pharmacological Actions
:
Gastroprotective
[+]
Nigella sativa exerts a therapeutic effect on cholestatic liver injury in bile duct ligated rats.
Dec 31, 2009
Click here to read the entire abstract
Pubmed Data
: Cell Biochem Funct. 2010 Jan ;28(1):83-8. PMID:
20029957
Article Published Date
: Dec 31, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Cholestasis
,
Liver Damage
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Nigella sativa exerts a therapeutic protective effect in diabetes by decreasing oxidative stress and preserving pancreatic beta-cell integrity.
Jun 30, 2004
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Anat Rec A Discov Mol Cell Evol Biol. 2004 Jul ;279(1):685-91. PMID:
15224410
Article Published Date
: Jun 30, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetes: Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Malondialdehyde Down-regulation
,
Pancreato Protective Agents
Additional Keywords
:
Plant Extracts
[+]
Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat.
Sep 30, 2004
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2004 Oct ;94(2-3):251-9. PMID:
15325727
Article Published Date
: Sep 30, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hyperlipidemia
,
Insulin Resistance
Pharmacological Actions
:
Hypolipidemic
,
Insulin Sensitizers
Additional Keywords
:
Plant Extracts
Problem Substances
:
Insulin
[+]
Nigella sativa extract affects conditioned place preference induced by morphine in rats, indicating it may have therapeutic value in treating morphine dependence and/or tolerance.
Sep 30, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
:
Anc Sci Life.
2012 Oct;32(2):82-8. doi: 10.4103/0257-7941.118537.
Article Published Date
: Sep 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Morphine Tolerance/Dependence
[+]
Nigella sativa extract has an anti-fatigue activity against exhaustive swimming.
Mar 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Rep. 2017 Apr ;6(4):468-474. Epub 2017 Feb 24. PMID:
28413647
Article Published Date
: Mar 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Fatigue: Excercise-Induced
Therapeutic Actions
:
Exercise: Swimming
Pharmacological Actions
:
Antioxidants
[+]
Nigella Sativa extract has shown protective effects on kidneys against aspirin-induced damage.
Dec 31, 2020
Click here to read the entire abstract
Pubmed Data
: J Ayub Med Coll Abbottabad. 2021 Jan-Mar;33(1):39-43. PMID:
33774952
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Aspirin-Induced Toxicity
,
Kidney Damage: Drug-Induced
Pharmacological Actions
:
Renoprotective
Problem Substances
:
Aspirin
[+]
Nigella sativa extract possesses hepatoprotective action against paracetamol induced acute hepatoxicity.
Mar 31, 2014
Click here to read the entire abstract
Pubmed Data
: Pak J Biol Sci. 2014 Apr ;17(4):517-22. PMID:
25911839
Article Published Date
: Mar 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Acetaminophen (Tylenol) Toxicity
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
Additional Keywords
:
Phytotherapy
,
Plant Extracts
Problem Substances
:
Paracetamol
[+]
Nigella sativa has a protective roll against the initiation of colon carcinogenesis.
Sep 30, 2008
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2008 Oct ;22(10):1311-23. PMID:
18570215
Article Published Date
: Sep 30, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Selenium
,
Thymoquinone
,
Vitamin A
Diseases
:
Colon Cancer
,
DNA damage
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antioxidants
,
Malondialdehyde Down-regulation
Additional Keywords
:
Plant Extracts
[+]
Nigella sativa has a significant nephroprotective activity on paracetamol-induced nephrotoxicity.
Mar 08, 2016
Click here to read the entire abstract
Pubmed Data
: Pharm Biol. 2016 Mar 9:1-10. Epub 2016 Mar 9. PMID:
26956915
Article Published Date
: Mar 08, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Malondialdehyde Down-regulation
,
Renoprotective
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Nigella sativa has protective effect on aspirin-induced nephrotoxicity in rats.
Sep 30, 2018
Click here to read the entire abstract
Pubmed Data
: J Coll Physicians Surg Pak. 2018 Oct ;28(10):735-738. PMID:
30266114
Article Published Date
: Sep 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Aspirin-Induced Toxicity
,
Kidney Damage: Drug-Induced
Pharmacological Actions
:
Renoprotective
Additional Keywords
:
Phytotherapy
,
Plant Extracts
Problem Substances
:
Aspirin
[+]
Nigella sativa has protective effects against radiation-induced damage.
Feb 16, 2016
Click here to read the entire abstract
Pubmed Data
: Pathol Res Pract. 2016 Feb 17. Epub 2016 Feb 17. PMID:
26944830
Article Published Date
: Feb 16, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Mucosal Damage: Radiation Induced
Pharmacological Actions
:
Malondialdehyde Down-regulation
,
Radioprotective
Anti Therapeutic Actions
:
Radiotherapy
[+]
Nigella sativa is a potent chemopreventive agent and may suppress potassium bromate-mediated renal oxidative stress, toxicity and tumour promotion.
Mar 31, 2003
Click here to read the entire abstract
Pubmed Data
: Hum Exp Toxicol. 2003 Apr ;22(4):193-203. PMID:
12755470
Article Published Date
: Mar 31, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Kidney Cancer
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antioxidants
,
Chemopreventive
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Nigella sativa is a potent chemopreventive agent and suppresses Fe-NTA-induced oxidative stress, hyperproliferative response and renal carcinogenesis.
Mar 31, 2005
Click here to read the entire abstract
Pubmed Data
: Eur J Cancer Prev. 2005 Apr ;14(2):159-68. PMID:
15785320
Article Published Date
: Mar 31, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Kidney Cancer
,
Kidney Cancer: Prevention
,
Oxidative Stress
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antioxidants
,
Antiproliferative
,
Chemopreventive
Additional Keywords
:
Plant Extracts
[+]
Nigella sativa is protective against methotrexate induced nephrotoxicity.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Intercult Ethnopharmacol. 2017 Jan-Mar;6(1):9-13. Epub 2016 Dec 22. PMID:
28163954
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Drug-Induced Toxicity: Methotrexate
Pharmacological Actions
:
Chemoprotective Agents
,
Malondialdehyde Down-regulation
,
Renoprotective
[+]
Nigella sativa L. as immunomodulator and preventive effect on renal tissue damage of lupus mice induced by pristane.
Mar 31, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Heliyon. 2022 Apr ;8(4):e09242. Epub 2022 Apr 6. PMID:
35450390
Article Published Date
: Mar 31, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Systemic Lupus Erythematosus
Pharmacological Actions
:
Immunomodulatory
,
Renoprotective
[+]
Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats.
Aug 31, 2000
Click here to read the entire abstract
Pubmed Data
: Arzneimittelforschung. 2000 Sep ;50(9):832-6. PMID:
11050701
Article Published Date
: Aug 31, 2000
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Anticholesteremic Agents
,
Hepatoprotective
Additional Keywords
:
Plant Oils
[+]
Nigella sativa L. supplementation greatly improves lead-induced neurotoxicity in early life and provides neuroprotective and antioxidant potentials.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Toxicol Res (Camb). 2018 Jan 1 ;7(1):32-40. Epub 2017 Oct 5. PMID:
30090560
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Lead Poisoning
,
Prenatal Chemical Exposures
Pharmacological Actions
:
Neuroprotective Agents
Problem Substances
:
Lead
[+]
Nigella sativa may be a beneficial agent in protection against ionizing radiation-related tissue injury.
Oct 31, 2006
Click here to read the entire abstract
Pubmed Data
: Photochem Photobiol. 2006 Nov-Dec;82(6):1691-6. PMID:
17387769
Article Published Date
: Oct 31, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemotherapy and Radiation Toxicity
Pharmacological Actions
:
Radioprotective
Anti Therapeutic Actions
:
Low Dose Ionizing Radiation
[+]
Nigella sativa may be clinically useful for protecting beta-cells against oxidative stress.
Sep 30, 2009
Click here to read the entire abstract
Pubmed Data
: J Mol Histol. 2009 Oct ;40(5-6):379-85. Epub 2010 Jan 5. PMID:
20049514
Article Published Date
: Sep 30, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetes: Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Pancreato Protective Agents
Additional Keywords
:
Phytotherapy
[+]
Nigella sativa oil (NSO) and its active component, TQ, clearly protect brain tissue from radiation-induced nitrosative stress.
Nov 20, 2013
Click here to read the entire abstract
Pubmed Data
:
Phytomedicine.
2013 Nov 21. pii: S0944-7113(13)00432-7. doi: 10.1016/j.phymed.2013.10.023. [Epub ahead of print]
Article Published Date
: Nov 20, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Cancers: Radiation-Induced
,
Chemotherapy and Radiation Toxicity
Pharmacological Actions
:
Radioprotective
[+]
Nigella sativa oil alleviates mouse testis and sperm abnormalities induced by BPA.
May 13, 2022
Click here to read the entire abstract
Pubmed Data
: Comb Chem High Throughput Screen. 2022 May 14. Epub 2022 May 14. PMID:
35570547
Article Published Date
: May 13, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Bisphenol Toxicity
,
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Antioxidants
,
Malondialdehyde Down-regulation
Problem Substances
:
Bisphenol A
[+]
Nigella sativa oil ameliorates carbon tetrachloride-induced hepatotoxicity.
Dec 09, 2019
Click here to read the entire abstract
Pubmed Data
: J Food Biochem. 2019 Dec 10:e13108. Epub 2019 Dec 10. PMID:
31823399
Article Published Date
: Dec 09, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
[+]
Nigella sativa oil ameliorates sodium nitrite-induced nephrotoxicity in animals.
Jul 28, 2015
Click here to read the entire abstract
Pubmed Data
: Redox Rep. 2015 Jul 29. Epub 2015 Jul 29. PMID:
26221999
Article Published Date
: Jul 28, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Kidney Fibrosis
,
Oxidative Stress
,
Sodium nitrate toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Renoprotective
Problem Substances
:
Sodium Nitrate
[+]
Nigella sativa oil and chromium picolinate monotherapy can reduce fructose-induced insulin resistance.
Oct 03, 2017
Click here to read the entire abstract
Pubmed Data
: Biol Trace Elem Res. 2017 Oct 4. Epub 2017 Oct 4. PMID:
28975521
Article Published Date
: Oct 03, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
High Fructose Diet
,
Hyperinsulinism
Pharmacological Actions
:
Insulin Sensitizers
[+]
Nigella sativa oil and Thymoquinone correct STZ-diabetes-induced alterations in CK-MB and brain monoamines due to their antioxidant properties.
Dec 31, 2008
Click here to read the entire abstract
Pubmed Data
: Pharmacology. 2009 ;84(3):127-34. Epub 2009 Aug 13. PMID:
19684436
Article Published Date
: Dec 31, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Diabetic Neuropathies
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Nigella sativa oil and thymoquinone have protective effects against toxicity induced by the anticancer drug cyclophosphamide.
Dec 31, 2009
Click here to read the entire abstract
Pubmed Data
: Br J Biomed Sci. 2010 ;67(1):20-8. PMID:
20373678
Article Published Date
: Dec 31, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Chemotherapy-Induced Toxicity: Cyclophosphamide
,
Oxidative Stress
Pharmacological Actions
:
Chemoprotective Agents
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Nigella sativa oil and thymoquinone may have protective effects during cerebral ischemia-reperfusion injury.
Aug 31, 2007
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2007 Sep ;14(9):621-7. Epub 2007 Feb 8. PMID:
17291733
Article Published Date
: Aug 31, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Cerebral Ischemia
,
Lipid Peroxidation
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Phytotherapy
[+]
Nigella sativa oil and thymoquinone maybe useful in amelioration of the intestinal toxicity associated with long-term cisplatin chemotherapy.
Jan 03, 2018
Click here to read the entire abstract
Pubmed Data
: Naunyn Schmiedebergs Arch Pharmacol. 2018 Jan 4. Epub 2018 Jan 4. PMID:
29302711
Article Published Date
: Jan 03, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Chemoprotective Agents
Additional Keywords
:
Chemoprotective Agents
,
Chemotherapy-Induced Toxicity: Cisplatin
,
Nigella sativa (aka Black Seed)
,
thymoquinone
[+]
Nigella sativa oil and Thymoquinone reduce oxidative stress in the brain tissue of rats exposed to full head irradiation.
Oct 21, 2019
Click here to read the entire abstract
Pubmed Data
: Int J Radiat Biol. 2019 Oct 22:1-28. Epub 2019 Oct 22. PMID:
31638880
Article Published Date
: Oct 21, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Brain: Oxidative Stress
,
Radiotherapy
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
,
Radioprotective
[+]
Nigella sativa oil and thymoquinone treatment decreased albuminuria in experimental models of the diabetic nephropathy.
May 31, 2016
Click here to read the entire abstract
Pubmed Data
: Eur Rev Med Pharmacol Sci. 2016 Jun ;20(12):2680-8. PMID:
27383323
Article Published Date
: May 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
MicroRNA modulator
,
Vascular Endothelial Growth Factor A Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
Nigella sativa oil appears to have a therapeutic potential in opioid tolerance and dependence.
Sep 30, 2010
Click here to read the entire abstract
Pubmed Data
: Neurochem Res. 2010 Oct ;35(10):1557-65. Epub 2010 Jun 15. PMID:
20552271
Article Published Date
: Sep 30, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Morphine Tolerance/Dependence
,
Oxidative Stress
Pharmacological Actions
:
Nitric Oxide Inhibitor
Additional Keywords
:
Plant Oils
[+]
Nigella sativa oil can protect against Cyclophosphamide-induced DNA damage and hepatotoxicity.
Mar 31, 2017
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2017 Apr ;69(3):498-504. Epub 2017 Feb 17. PMID:
28287318
Article Published Date
: Mar 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions
:
Antioxidants
,
Chemoprotective Agents
,
Hepatoprotective
[+]
Nigella sativa oil could be a promising agent against moto-cognitive dysfunction and cerebelo-hippocampal alterations induced by cannabis.
Aug 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Malays J Med Sci. 2016 Sep ;23(5):17-28. Epub 2016 Oct 5. PMID:
27904421
Article Published Date
: Aug 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabis
,
Nigella sativa (aka Black Seed)
Diseases
:
Cognitive Decline/Dysfunction
Additional Keywords
:
Plant Extracts
[+]
Nigella sativa oil has a possible benefit as disease modifying agents for the insulin resistance in the brain.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2017 ;12(5):e0172429. Epub 2017 May 15. PMID:
28505155
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
Nigella sativa oil has a protective effect on the myocardium of streptozotocin-induced diabetes.
Jun 30, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Acta Endocrinol (Buchar). 2019 Jul-Sep;15(3):289-294. PMID:
32010345
Article Published Date
: Jun 30, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetic Complications
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Nigella sativa oil imparted a protective action against ethanol induced ulcer in rats.
Aug 31, 2000
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2000 Sep ;72(1-2):299-304. PMID:
10967486
Article Published Date
: Aug 31, 2000
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Alcohol Toxicity
,
Gastric Ulcer
Pharmacological Actions
:
Anti-Ulcer Agents
,
Gastroprotective
Additional Keywords
:
Plant Oils
[+]
Nigella sativa oil is a promising natural radioprotective agent against immunosuppressive and oxidative effects of ionizing radiation.
May 31, 2010
Click here to read the entire abstract
Pubmed Data
: Immunopharmacol Immunotoxicol. 2010 Jun ;32(2):284-96. PMID:
20105084
Article Published Date
: May 31, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemotherapy and Radiation Toxicity
,
Lipid Peroxidation
Pharmacological Actions
:
Antioxidants
,
Radioprotective
[+]
Nigella sativa oil may be a safe therapeutic treatment for preventing gastric ulcers.
Mar 21, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2023 Mar 22 ;15(6). Epub 2023 Mar 22. PMID:
36986262
Article Published Date
: Mar 21, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Alcohol Toxicity
,
Gastric Ulcer
Pharmacological Actions
:
Anti-Ulcer Agents
,
Gastroprotective
Additional Keywords
:
Plant Extracts
[+]
Nigella sativa oil may help prevent the accompanying gastrointestinal dysfunction in cisplatin chemotherapy.
Feb 14, 2017
Click here to read the entire abstract
Pubmed Data
: Exp Toxicol Pathol. 2017 Feb 15. Epub 2017 Feb 15. PMID:
28215571
Article Published Date
: Feb 14, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Chemoprotective Agents
,
Gastroprotective
Additional Keywords
:
Chemoprotective Agents
,
Chemotherapy-Induced Toxicity: Cisplatin
,
Gastroprotective
,
Nigella sativa (aka Black Seed)
[+]
Nigella sativa oil may play a role against the alterations caused by S. mansoni infection.
Dec 31, 2001
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2002 Jan ;79(1):1-11. PMID:
11744288
Article Published Date
: Dec 31, 2001
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Schistosomiasis
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Plant Oils
[+]
Nigella sativa oil might be beneficial for controlling hypertension.
Oct 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Clinics (Sao Paulo). 2015 Nov ;70(11):751-7. PMID:
26602523
Article Published Date
: Oct 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
,
Heme oxygenase-1 up-regulation
Additional Keywords
:
Natural Substances Versus Drugs
[+]
Nigella sativa oil mitigates xerostomia and preserves salivary function in radiotherapy.
Jul 31, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Laryngoscope Investig Otolaryngol. 2023 Aug ;8(4):912-920. Epub 2023 Jul 25. PMID:
37621284
Article Published Date
: Jul 31, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Xerostomia
Pharmacological Actions
:
Radioprotective
[+]
Nigella sativa oil protects against cadmium-induced intestinal toxicity.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Avicenna J Phytomed. 2022 ;12(3):241-256. PMID:
36186933
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Cadmium Poisoning
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Gastrointestinal Agents
,
Interleukin-2 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances
:
Cadmium
[+]
Nigella sativa oil protects kidney tissue against oxygen free radicals.
Dec 31, 2007
Click here to read the entire abstract
Pubmed Data
: Am J Nephrol. 2008 ;28(3):517-22. Epub 2008 Jan 25. PMID:
18223305
Article Published Date
: Dec 31, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Drug-Induced Toxicity: Cyclosporine
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Nigella sativa oil protects the rat ovary from oxidative injury due to ischemia-reperfusion.
Oct 20, 2017
Click here to read the entire abstract
Pubmed Data
: Med Sci Monit. 2017 Oct 21 ;23:5027-5033. Epub 2017 Oct 21. PMID:
29055179
Article Published Date
: Oct 20, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Ischemia
Pharmacological Actions
:
Antioxidants
[+]
Nigella sativa oil seems to be a highly promising agent for protecting tissues from oxidative damage and preventing organ damage due to renal I/R.
Jun 30, 2008
Click here to read the entire abstract
Pubmed Data
: Nephrol Dial Transplant. 2008 Jul ;23(7):2206-12. Epub 2008 Jan 22. PMID:
18211980
Article Published Date
: Jun 30, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Ischemia
,
Kidney Damage
Pharmacological Actions
:
Malondialdehyde Down-regulation
,
Renoprotective
,
Superoxide Dismutase Up-regulation
[+]
Nigella sativa oil significantly attenuated adjuvant-arthritis, and the higher dose prevented the development of arthritis with an inhibition of 56%.
Aug 24, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Antioxidants (Basel). 2019 Aug 25 ;8(9). Epub 2019 Aug 25. PMID:
31450670
Article Published Date
: Aug 24, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antinoceceptive
,
Interleukin-6 Downregulation
,
Prophylactic Agents
Additional Keywords
:
Risk Reduction
[+]
Nigella sativa oil significantly lowered blood glucose concentrations in diabetic rats.
Apr 30, 2002
Click here to read the entire abstract
Pubmed Data
: Planta Med. 2002 May ;68(5):465-6. PMID:
12058330
Article Published Date
: Apr 30, 2002
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hypoglycemia
Pharmacological Actions
:
Hypoglycemic Agents
Additional Keywords
:
Plant Oils
[+]
Nigella sativa oil treatment attenuated the effects of bleomycin induced pulmonary fibrosis.
Apr 12, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Apr 13 ;90:626-637. Epub 2017 Apr 13. PMID:
28412654
Article Published Date
: Apr 12, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Fibrosis
,
Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions
:
Anti-Fibrotic
,
Chemoprotective Agents
[+]
Nigella sativa oil was found to be the most effective in preventing PTZ-induced seizures relative to valproate.
Aug 31, 2005
Click here to read the entire abstract
Pubmed Data
: Neuropharmacology. 2005 Sep ;49(4):456-64. PMID:
15913671
Article Published Date
: Aug 31, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Seizures
Pharmacological Actions
:
Anticonvulsants
,
Antioxidants
,
Malondialdehyde Down-regulation
Additional Keywords
:
Superiority of Natural Substances versus Drugs
[+]
Nigella sativa or L-Carnitine has mitigated effects on metabolic and histopathological changes in the liver tissues of rats fed with HFD.
Jun 10, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Pharmacother. 2021 Jun 11 ;141:111818. Epub 2021 Jun 11. PMID:
34126354
Article Published Date
: Jun 10, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
High Fat Diet
,
Obesity
Pharmacological Actions
:
Hepatoprotective
,
Hypolipidemic
Additional Keywords
:
Anti-Obesity Agents
[+]
Nigella sativa possesses a potential ability to prevent hippocampal neural damage which is accompanied with improving effects on memory.
Jun 30, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Tradit Complement Med. 2016 Jul ;6(3):262-8. Epub 2015 Aug 11. PMID:
27419091
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Seizures
Pharmacological Actions
:
Neuroprotective Agents
[+]
Nigella sativa Post-conditioning ameliorated cardiac functions in isolated rat heart during I/R injuries by improving myocardial oxidative stress states.
Jul 07, 2019
Click here to read the entire abstract
Pubmed Data
: Cardiovasc Toxicol. 2019 Jul 8. Epub 2019 Jul 8. PMID:
31286398
Article Published Date
: Jul 07, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
[+]
Nigella sativa provides a therapeutic effect by decreasing the number of fungal colonies and increasing IgM levels.
Jul 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Med Glas (Zenica). 2020 Aug 1 ;17(2). Epub 2020 Aug 1. PMID:
32153156
Article Published Date
: Jul 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Candidiasis: Vulvovaginal
Pharmacological Actions
:
Antifungal Agents
[+]
Nigella Sativa reverses osteoporosis in ovariectomized rats.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2014 ;14(1):22. Epub 2014 Jan 14. PMID:
24422662
Article Published Date
: Dec 31, 2013
Study Type
: Insect Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Menopausal Syndrome
,
Osteopenia
,
Osteoporosis
,
Ovarian Failure
Additional Keywords
:
Ovariectomy-Induced Changes
[+]
Nigella sativa seed extract demonstrated incredibly positive effects on enhanced bone healing in this experimental osteoporotic model.
Aug 09, 2016
Click here to read the entire abstract
Pubmed Data
: J Craniofac Surg. 2016 Aug 10. Epub 2016 Aug 10. PMID:
27513784
Article Published Date
: Aug 09, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Osteoporosis
Additional Keywords
:
Ovariectomy-Induced Changes
[+]
Nigella sativa seed extract has protective effects against acetaminophen induced hepatotoxicity and metabolic disturbances in rats.
Feb 29, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Asian Pac J Trop Med. 2016 Mar ;9(3):221-7. Epub 2016 Jan 13. PMID:
26972391
Article Published Date
: Feb 29, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Acetaminophen (Tylenol) Toxicity
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Nigella sativa seed oil has a protective effect against cisplatin induced acute kidney injury.
Dec 04, 2016
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2016 Dec 5 ;85:7-15. Epub 2016 Dec 5. PMID:
27930989
Article Published Date
: Dec 04, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Chemoprotective Agents
,
Renoprotective
[+]
Nigella sativa seeds possess potent anti-inflammatory effects that were not as strong as diclofenac sodium but was more prolonged in effect.
Jun 30, 2015
Click here to read the entire abstract
Pubmed Data
: J Ayub Med Coll Abbottabad. 2015 Jul-Sep;27(3):523-6. PMID:
26720998
Article Published Date
: Jun 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Natural Substances Versus Drugs
Problem Substances
:
Diclofenac
[+]
Nigella sativa toothpaste promotes anti-inflammatory and anti-destructive effects in a rat model of periodontitis.
Apr 30, 2022
Click here to read the entire abstract
Pubmed Data
: Arch Oral Biol. 2022 May ;137:105396. Epub 2022 Mar 9. PMID:
35286946
Article Published Date
: Apr 30, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Periodontitis
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Nigella sativa treatment might be beneficial in lung injury and have potential clinical use.
Dec 31, 2008
Click here to read the entire abstract
Pubmed Data
: Acta Histochem. 2009 ;111(5):393-403. Epub 2009 May 9. PMID:
19428057
Article Published Date
: Dec 31, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Fibrosis
,
Lung Damage
Pharmacological Actions
:
Anti-Fibrotic
,
Anti-Inflammatory Agents
Additional Keywords
:
Plant Extracts
[+]
Nigella sativa treatment might be beneficial in spinal cord tissue damage.
Feb 28, 2006
Click here to read the entire abstract
Pubmed Data
: Hum Exp Toxicol. 2006 Mar ;25(3):127-33. PMID:
16634331
Article Published Date
: Feb 28, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Lipid Peroxidation
,
Spinal Cord Injuries
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Malondialdehyde Down-regulation
,
Neuroprotective Agents
,
Superoxide Dismutase Up-regulation
[+]
Nigella Sativa treatment protected the rat's intestinal tissue against intestinal ischemia-reperfusion injury.
Jan 31, 2010
Click here to read the entire abstract
Pubmed Data
: J Invest Surg. 2010 Feb ;23(1):21-7. PMID:
20233001
Article Published Date
: Jan 31, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Intestinal Ischemia
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Phytotherapy
[+]
Nigella sativa’s anti-inflammatory and antioxidative effects in experimental inflammation.
Sep 25, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Antioxidants (Basel). 2020 Sep 26 ;9(10). Epub 2020 Sep 26. PMID:
32993150
Article Published Date
: Sep 25, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Malondialdehyde Down-regulation
[+]
Olive oil and N. sativa oil have a protective effect against carbon tetrachloride induced hepatotoxicity.
Nov 03, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2016 Nov 4 ;16(1):438. Epub 2016 Nov 4. PMID:
27814700
Article Published Date
: Nov 03, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Olive Oil
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Plant Extracts
[+]
Omega-3 fatty acids, black seed oil and curcuminoids have a therapeutic role in gastritits in an animal model.
Oct 01, 2007
Click here to read the entire abstract
Pubmed Data
: Eur J Nutr. 2007 Oct;46(7):391-6. Epub 2007 Sep 20. PMID:
18368490
Article Published Date
: Oct 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Nigella sativa (aka Black Seed)
,
Omega-3 Fatty Acids
Diseases
:
Gastritis
Additional Keywords
:
Plant Extracts
[+]
Oral administration of Nigella sativa oil and thymoquinone attenuates long term cisplatin treatment induced toxicity.
Dec 05, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Dec 6. Epub 2017 Dec 6. PMID:
29223554
Article Published Date
: Dec 05, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Antioxidants
,
Chemoprotective Agents
[+]
Oral administration of Nigella sativa oil attenuates arsenic-induced redox imbalance, DNA damage, metabolic distress.
Aug 31, 2023
Click here to read the entire abstract
Pubmed Data
: J Trace Elem Med Biol. 2023 Sep ;79:127238. Epub 2023 Jun 3. PMID:
37343449
Article Published Date
: Aug 31, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Arsenic Poisoning
,
DNA damage
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Gastroprotective
Problem Substances
:
Arsenic
[+]
Oral Nigella sativa oil administration alleviates arsenic-induced redox imbalance, DNA damage, and metabolic and histological alterations.
Mar 29, 2021
Click here to read the entire abstract
Pubmed Data
: Environ Sci Pollut Res Int. 2021 Mar 30. Epub 2021 Mar 30. PMID:
33786765
Article Published Date
: Mar 29, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemically-Induced Liver Damage
,
DNA damage
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
[+]
Peganum harmala and Nigella sativa: anti-leishmanial activity against Leishmania major.
Dec 31, 2020
Click here to read the entire abstract
Pubmed Data
: Ann Parasitol. 2021 ;67(2):313-319. PMID:
34598403
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Syrian rue
Diseases
:
Leishmaniasis
Pharmacological Actions
:
Leishmanicidal
[+]
Pharmacological potential of zonisamide and Nigella sativa per se and combination in high-impact trauma device-induced traumatic brain injury.
Nov 23, 2022
Click here to read the entire abstract
Pubmed Data
: Fundam Clin Pharmacol. 2022 Nov 24. Epub 2022 Nov 24. PMID:
36424858
Article Published Date
: Nov 23, 2022
Study Type
: Insect Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Traumatic Brain Injury
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Pretreatment with Nigella sativa has a protective effect against renal damage induced by renal reperfusion.
Apr 30, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran J Kidney Dis. 2016 May ;10(3):135-43. PMID:
27225721
Article Published Date
: Apr 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Kidney Damage
Pharmacological Actions
:
Renoprotective
[+]
Prevention of doxorubicin-induced experimental cardiotoxicity by Nigella sativa.
Jan 31, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Rev Port Cardiol. 2022 Feb ;41(2):99-105. Epub 2022 Jan 22. PMID:
36062712
Article Published Date
: Jan 31, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Cardioprotective
,
Chemoprotective Agents
[+]
Propolis, caffeic acid phenethyl ester, nigella sativa oil and thymoquinone could prevent cataractogenesis in ionizing radiation-induced cataracts in the lenses of rats.
Apr 09, 2015
Click here to read the entire abstract
Pubmed Data
: Wien Klin Wochenschr. 2015 Apr 10. Epub 2015 Apr 10. PMID:
25860848
Article Published Date
: Apr 09, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Bee Propolis
,
Caffeic acid phenethyl ester
,
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Cataract: Radiation-Induced
Pharmacological Actions
:
Radioprotective
Additional Keywords
:
Plant Extracts
Anti Therapeutic Actions
:
Low Dose Ionizing Radiation
[+]
Protection against radiation-induced oxidative damage by an ethanolic extract of Nigella sativa.
Aug 31, 2010
Click here to read the entire abstract
Pubmed Data
: Int J Radiat Biol. 2010 Sep ;86(9):719-31. PMID:
20670109
Article Published Date
: Aug 31, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemotherapy and Radiation Toxicity
,
Lipid Peroxidation
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Radioprotective
Additional Keywords
:
Plant Extracts
[+]
Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats.
Dec 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
:
PMID: 23947821
Article Published Date
: Dec 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Diabetes Mellitus: Type 1
,
Diabetes Mellitus: Type 2
Additional Keywords
:
Beta Cell Regeneration
[+]
Protective effect of Nigella sativa and onion extract against 5-fluorouracil-induced hepatic toxicity.
Dec 27, 2021
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2021 Dec 28:1-14. Epub 2021 Dec 28. PMID:
34963383
Article Published Date
: Dec 27, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Onion
Diseases
:
Chemotherapy-Induced Toxicity: 5-fluorouracil
Pharmacological Actions
:
Chemoprotective Agents
,
Hepatoprotective
[+]
Protective effect of Nigella sativa oil against acetamiprid induced reproductive toxicity in male rats.
Jul 02, 2017
Click here to read the entire abstract
Pubmed Data
: Drug Chem Toxicol. 2017 Jul 3:1-7. Epub 2017 Jul 3. PMID:
28669218
Article Published Date
: Jul 02, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Pesticide Toxicity
Pharmacological Actions
:
Cytoprotective
Problem Substances
:
Pesticides
[+]
Protective effects of Nigella sativa oil against carboplatin-induced liver damage in rats.
Jan 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Pharmacother. 2019 Feb ;110:742-747. Epub 2018 Dec 13. PMID:
30554112
Article Published Date
: Jan 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemotherapy and Radiation Toxicity
Pharmacological Actions
:
Chemoprotective Agents
,
Hepatoprotective
[+]
Protective effects of nigella sativa oil against gentamicin-induced ototoxicity.
Nov 27, 2022
Click here to read the entire abstract
Pubmed Data
: Int J Pediatr Otorhinolaryngol. 2022 Nov 28 ;164:111405. Epub 2022 Nov 28. PMID:
36481814
Article Published Date
: Nov 27, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions
:
Chemoprotective Agents
[+]
Renoprotective effect of Nigella sativa against cisplatin-induced nephrotoxicity and oxidative stress.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Saudi J Kidney Dis Transpl. 2018 Jan-Feb;29(1):19-29. PMID:
29456204
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Antioxidants
,
Chemoprotective Agents
,
Renoprotective
[+]
Repeated administration of Nigella sativa oil may exert memory enhancing effects against restrained stress.
Aug 31, 2017
Click here to read the entire abstract
Pubmed Data
: Pak J Pharm Sci. 2017 Sep ;30(5(Supplementary)):2039-2046. PMID:
29105641
Article Published Date
: Aug 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Memory Disorders
Pharmacological Actions
:
Acetylcholinesterase Inhibitor
,
Antioxidants
,
Neuroprotective Agents
[+]
Role of thymoquinone and ebselen in the prevention of sodium arsenite-induced nephrotoxicity.
Dec 16, 2018
Click here to read the entire abstract
Pubmed Data
: Hum Exp Toxicol. 2018 Dec 17:960327118818246. Epub 2018 Dec 17. PMID:
30558456
Article Published Date
: Dec 16, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Selenium
,
Thymoquinone
Diseases
:
Kidney Damage: Chemically-Induced
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Renoprotective
Problem Substances
:
Arsenite
[+]
Synergistic effect of honey and Nigella sativa on wound healing in rats.
May 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Acta Cir Bras. 2018 Jun ;33(6):518-523. PMID:
30020313
Article Published Date
: May 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Honey
,
Nigella sativa (aka Black Seed)
Diseases
:
Wound Healing
Additional Keywords
:
Natural Substance Synergy
[+]
The active constituent of black seed, thymoquinone, reversed non-alcoholic fatty liver associated with experimental hypothyroidism in rats.
Jan 01, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Rom J Morphol Embryol. 2019 ;60(2):479-486. PMID:
31658321
Article Published Date
: Jan 01, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hypothyroidism
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidant
,
Hepatoprotective
[+]
The ameliorative effects of Nigella sativa, thymoquinone, and bentonite against aflatoxicosis in broilers.
Dec 05, 2021
Click here to read the entire abstract
Pubmed Data
: Br Poult Sci. 2021 Dec 6:1-8. Epub 2021 Dec 6. PMID:
34738498
Article Published Date
: Dec 05, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Bentonite
,
Nigella sativa (aka Black Seed)
,
Thymoquinone
Diseases
:
Aflatoxicosis
Pharmacological Actions
:
Antioxidants
,
Detoxifier
,
Nrf2 activation
[+]
The combination of nigella sativa oil and pyrimethamine had a synergistic effect in the treatment of toxoplasmosis.
Oct 06, 2015
Click here to read the entire abstract
Pubmed Data
: Parasitol Res. 2015 Oct 7. Epub 2015 Oct 7. PMID:
26446086
Article Published Date
: Oct 06, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Toxoplasma gondii Infection
,
Toxoplasmosis
Therapeutic Actions
:
Integrative Medicine
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
The current findings suggested a water soluble extract if Nigella sativa has promising anxiolytic and anti-inflammatory activities.
Oct 02, 2019
Click here to read the entire abstract
Pubmed Data
: Nat Prod Res. 2019 Oct 3:1-6. Epub 2019 Oct 3. PMID:
31578877
Article Published Date
: Oct 02, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Anxiety
,
Inflammation
Pharmacological Actions
:
Anti-Anxiety Agents
,
Anti-Inflammatory Agents
[+]
The effect of chronic supplementation of Nigella sativa on splenocytes response in rats following treadmill exercise.
May 28, 2019
Click here to read the entire abstract
Pubmed Data
: Drug Chem Toxicol. 2019 May 29:1-6. Epub 2019 May 29. PMID:
31137984
Article Published Date
: May 28, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Fatigue: Excercise-Induced
Therapeutic Actions
:
Exercise
Pharmacological Actions
:
Immunomodulatory
[+]
The effect of dietary supplementation with Nigella sativa (black seeds) mediates immunological function.
Apr 05, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2021 Apr 6 ;11(1):7542. Epub 2021 Apr 6. PMID:
33824353
Article Published Date
: Apr 05, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Pharmacological Actions
:
Immunostimulatory
[+]
The effect of hydroalcoholic extract of Nigella Sativa seed on dehydroepiandrosterone-induced polycystic ovarian syndrome.
Feb 28, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Reprod Biomed. 2021 Mar ;19(3):271-282. Epub 2021 Mar 21. PMID:
33842824
Article Published Date
: Feb 28, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Polycystic Ovary Syndrome
Pharmacological Actions
:
Antioxidants
[+]
The effects of black seed supplementation on cardiovascular risk factors in patients with nonalcoholic fatty liver disease.
Jul 09, 2019
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2019 Jul 10. Epub 2019 Jul 10. PMID:
31293021
Article Published Date
: Jul 09, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Cardiovascular Diseases
,
Insulin Resistance
,
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
[+]
The essential oil extracted from Nigella sativa seeds produces smooth muscle relaxation.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Pak J Pharm Sci. 2016 Jan ;29(1):1-8. PMID:
26826822
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
,
Vasodilator Agents
Additional Keywords
:
Dose Response
,
Essential Oils
[+]
The essential oil of black cumin seed has potent analgesic and antiinflammatory activity.
Mar 01, 2004
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2004 Mar;18(3):195-9. PMID:
15103664
Article Published Date
: Mar 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Inflammation
,
Pain
Pharmacological Actions
:
Analgesics: Non-Narcotic
,
Anti-Inflammatory Agents
[+]
The positive effect of black seed (Nigella sativa L.) essential oil on thyroid hormones.
Jun 02, 2021
Click here to read the entire abstract
Pubmed Data
: J Food Biochem. 2021 Jun 3:e13801. Epub 2021 Jun 3. PMID:
34080722
Article Published Date
: Jun 02, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Hyperthyroidism
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Essential Oils
[+]
The potential therapeutic effect of Nigella sativa and Zingiber officinale extracts versus Nitazoxanide drug against experimentally induced cryptosporidiosis.
May 31, 2023
Click here to read the entire abstract
Pubmed Data
: J Parasit Dis. 2023 Jun ;47(2):329-339. Epub 2023 Mar 25. PMID:
37193490
Article Published Date
: May 31, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Ginger
,
Nigella sativa (aka Black Seed)
Diseases
:
Cryptosporidiosis
Pharmacological Actions
:
Antiparasitic Agents
Additional Keywords
:
Natural Substance Synergy
,
Superiority of Natural Substances versus Drugs
[+]
The present study demonstrates that the cytotoxic activity of blackseed extracts is a complex phenomenon.
May 31, 2007
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Braz J Med Biol Res. 2007 Jun ;40(6):839-47. PMID:
17581684
Article Published Date
: May 31, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Liver Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
Additional Keywords
:
Plant Extracts
[+]
The protective effect of Nigella sativa extract on lung inflammation and oxidative stress induced by lipopolysaccharide.
Feb 05, 2020
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2020 Feb 6 ;253:112653. Epub 2020 Feb 6. PMID:
32035219
Article Published Date
: Feb 05, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
The protective effect of Nigella sativa oil against experimentally induced cisplatin ototoxicity.
Nov 30, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Int Adv Otol. 2020 Dec ;16(3):346-352. PMID:
33136014
Article Published Date
: Nov 30, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Chemoprotective Agents
[+]
The protective effect of Nigella sativa seeds against monosodium glutamate-induced hepatic dysfunction.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Toxicol Rep. 2022 ;9:147-153. Epub 2022 Jan 28. PMID:
35145878
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
