Nobiletin

Name	AC	CK
Alzheimer's Disease	9	16
Inflammation	8	12
Cognitive Decline/Dysfunction	5	9
Colitis	5	9
High Fat Diet	4	8
Oxidative Stress	4	8
Neurodegenerative Diseases	4	7
Colon Cancer	4	6
Nonalcoholic fatty liver disease (NAFLD)	4	6
Obesity	4	6
Parkinson's Disease	4	6
Brain Inflammation	3	5
Breast Cancer	5	5
Cancers: Multi-Drug Resistant	4	5
Cholesterol: Oxidation	1	5
Diabetic Complications	3	5
Gestational Diabetes	1	5
Iron Overload	1	5
Lipopolysaccharide-Induced Toxicity	3	5
Lung Cancer	3	5
Aging	2	4
Cancers: All	4	4
Carcinoma: Non-Small-Cell Lung	3	4
Chemically-Induced Liver Damage	2	4
Colorectal Cancer	4	4
Dementia	3	4
Dyslipidemias	2	4
Insulin Resistance	2	4
Ischemia	2	4
Kidney Damage	2	4
Osteoporosis	2	4
Ovarian Cancer	3	4
Atherosclerosis	2	3
Cancer Metastasis	3	3
Cardiovascular Diseases	2	3
Cerebral Ischemia	2	3
Liver Injury: Ischemia/reperfusion	2	3
Myocardial Ischemia	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Alcohol Toxicity	1	2
Allergies	1	2
Brain Edema	1	2
Brain Ischemia	1	2
Breast Cancer: Chemically-Induced	1	2
Cadmium Poisoning	1	2
Cardiac Hypertrophy	1	2
Cardiomyopathy	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Colon Cancer: Prevention	1	2
Coronary Artery Disease	1	2
DNA damage	1	2
Diabetes Mellitus: Type 1	1	2
Endometriosis	1	2
Fibrosis	1	2
Gastric Cancer	2	2
Gastric Ulcer	1	2
Glioblastoma	1	2
Hepatic Steatosis	1	2
Histamine: Elevated	1	2
Hypothyroidism	1	2
Intestinal Permeability	1	2
Itching	1	2
Kidney Cancer	2	2
Kidney Damage: Drug-Induced	1	2
Metabolic Diseases	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Myocardial Infarction	1	2
Nasopharyngeal Cancer	1	2
Oral Cancer	2	2
Organ Transplantation: Liver	1	2
Osteoarthritis	1	2
Parkinsonian Disorders	1	2
Periodontitis	1	2
Prostate Cancer	2	2
Psychiatric Disorder: Conditioned Fear	1	2
Rheumatoid Arthritis	1	2
Stroke: Attenuation/Recovery	1	2
Stroke: Ischemic	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Thyroid Diseases	1	2
Acute Myeloid Leukemia	1	1
Arterial Calcification	1	1
Bladder Cancer	1	1
Breast Cancer: Triple Negative	1	1
Cancers: Drug Resistant	1	1
Chikungunya Virus	1	1
Chronic Myeloid Leukemia	1	1
Depression	1	1
Diabetes Mellitus: Type 2	1	1
Diabetic Nephropathy	1	1
Endothelial Dysfunction	1	1
Glioblastoma Multiforme	1	1
Heart Disease	1	1
Helicobacter Pylori Infection	1	1
Hepatitis B	1	1
Hepatitis C	1	1
High Fructose Diet	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Hypercalcemia	1	1
Hypertension	1	1
Hypoxia	1	1
Learning disorders	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Leukemia: Chronic myelogenous leukemia (CML)	1	1
Liver Cancer	1	1
Lung Injury: Acute	1	1
Macular Degeneration	1	1
Neurologic Disorders	1	1
Osteosarcoma	1	1
Pancreatic Cancer	1	1
Periodontal Diseases	1	1
Preterm Birth: Prevention	1	1
Skin Cancer	1	1
Skin Cancer: Prevention	1	1
Squamous cell carcinoma	1	1
Thyroid Cancer	1	1

Name	AC	CK
Anti-Inflammatory Agents	32	54
Antioxidants	25	43
Neuroprotective Agents	19	34
Antiproliferative	23	27
Tumor Necrosis Factor (TNF) Alpha Inhibitor	15	24
NF-kappaB Inhibitor	12	21
Anti-Apoptotic	12	20
Apoptotic	15	17
Interleukin-6 Downregulation	10	16
Interleukin-1 beta downregulation	9	14
Hepatoprotective	8	13
Anti-metastatic	10	12
Chemopreventive	9	12
Cardioprotective	7	11
Renoprotective	6	11
Chemotherapeutic	8	9
Hypolipidemic	6	9
Cell cycle arrest	7	8
Chemosensitizer	7	8
Cyclooxygenase 2 Inhibitors	6	8
Anticarcinogenic Agents	4	6
Hypoglycemic Agents	2	6
Matrix metalloproteinase-2 (MMP-2) inhibitor	4	6
Angiogenesis Inhibitors	4	5
Antithrombotic	1	5
Cardiovascular Agents	1	5
Matrix metalloproteinase-9 (MMP-9) inhibitor	4	5
Nitric Oxide Enhancer	1	5
Prophylactic Agents	1	5
Antineoplastic Agents	3	4
MicroRNA modulator	4	4
Nitric Oxide Inhibitor	3	4
Antihypertensive Agents	2	3
Antiviral Agents	3	3
Gastroprotective	2	3
Heme oxygenase-1 inducer	2	3
Vasodilator Agents	2	3
Anti-Allergic Agents	1	2
Chemoprotective Agents	1	2
Cyclin D1 Down-Regulation	2	2
Hypoxia-inducible factor-1 (HIF-1) inhibitor	1	2
Interleukin-10 upregulation	1	2
Interleukin-4 downregulation	1	2
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	2
Nrf2 activation	1	2
Osteoprotective	1	2
P21 Activation	2	2
Vascular Endothelial Growth Factor Inhibitors	1	2
Wnt/β-catenin signaling pathway modulation	2	2
Antidepressive Agents	1	1
Aromatase Inhibitors	1	1
Autophagy Inhibitors	1	1
Autophagy Up-regulation	1	1
Bcl-2 protein down-regulation	1	1
Bcl-xL down-regulation	1	1
Caspase-3 Activation	1	1
E-cadherin down-regulation	1	1
Enzyme Inhibitors	1	1
Interleukin-18 down-regulation	1	1
Interleukin-8 downregulation	1	1
Multidrug Resistance Gene Modulators	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
Pancreato Protective Agents	1	1
Postaglandin PGE2 downregulation	1	1
Prostaglandin PGE2 downregulation	1	1
STAT3 Inhibitor	1	1
Transforming growth factor beta (TGF-β) inhibitor	1	1
Tumor Suppressor Protein p53 Upregulation	1	1

[+]

Potential of nobiletin against Alzheimer's disease through inhibiting neuroinflammation.Mar 09, 2022

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Pubmed Data : Metab Brain Dis. 2022 Mar 10. Epub 2022 Mar 10. PMID: 35267136

Article Published Date : Mar 09, 2022

Study Type : Human In Vitro, Human Study

Additional Links

Substances : Nobiletin

Diseases : Alzheimer's Disease, Brain Inflammation

Pharmacological Actions : Neuroprotective Agents

[+]

Perilla seed oil in combination with nobiletin-rich ponkan powder enhances cognitive function in healthy elderly Japanese individuals.Feb 15, 2022

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2022 May 4 ;12(1):7271. Epub 2022 May 4. PMID: 35508494

Article Published Date : May 03, 2022

Study Type : Animal Study, In Vitro Study

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Substances : Nobiletin

Diseases : High Fat Diet

Pharmacological Actions : Gastrointestinal Agents

[+]

Nobiletin protects retinal ganglion cells in models of ocular hypertension.Jul 07, 2022

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Pubmed Data : Lab Invest. 2022 Jul 8. Epub 2022 Jul 8. PMID: 35804043

Article Published Date : Jul 07, 2022

Study Type : Animal Study, In Vitro Study

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Substances : Nobiletin

Diseases : Glaucoma

Pharmacological Actions : Neuroprotective Agents

[+]

ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer.Apr 18, 2022

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Pubmed Data : Cell Death Dis. 2022 Apr 19 ;13(4):374. Epub 2022 Apr 19. PMID: 35440077

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Pubmed Data : Front Aging Neurosci. 2022 ;14:964077. Epub 2022 Sep 16. PMID: 36185487

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Pubmed Data : Biomolecules. 2021 Jul 9 ;11(7). Epub 2021 Jul 9. PMID: 34356628

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Pubmed Data : Int J Environ Res Public Health. 2021 Aug 26 ;18(17). Epub 2021 Aug 26. PMID: 34501579

Article Published Date : Aug 25, 2021

Study Type : Animal Study, In Vitro Study

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Substances : Nobiletin

Diseases : Sciatic Nerve Crush Injury

Pharmacological Actions : Neuroprotective Agents, Regenerative

Additional Keywords : Nerve Regeneration

[+]

Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in animals.Aug 31, 2018

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Pubmed Data : J Lipid Res. 2018 Sep ;59(9):1714-1728. Epub 2018 Jul 15. PMID: 30008441

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Pubmed Data : Front Physiol. 2021 ;12:687744. Epub 2021 May 20. PMID: 34093242

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Nobiletin

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

[+]

Nobiletin ameliorates cardiac impairment and alleviates cardiac remodeling after acute myocardial infarction.Dec 31, 2020

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Pubmed Data : Biochem Biophys Res Commun. 2017 Aug 19. Epub 2017 Aug 19. PMID: 28830813

Article Published Date : Aug 18, 2017

Study Type : Animal Study

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Substances : Nobiletin

Diseases : Myocardial Infarction

Pharmacological Actions : Cardioprotective

[+]

Nobiletin attenuates cardiac dysfunction, oxidative stress, and inflammatory in streptozotocin: induced diabetic cardiomyopathy.May 31, 2016

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Pubmed Data : Mol Cell Biochem. 2016 Jun ;417(1-2):87-96. Epub 2016 May 10. PMID: 27160937

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Pubmed Data : Biomed Pharmacother. 2017 May ;89:732-741. Epub 2017 Mar 6. PMID: 28273635

Article Published Date : Apr 30, 2017

Study Type : Animal Study

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Substances : Nobiletin

Diseases : Liver Injury: Ischemia/reperfusion , Organ Transplantation: Liver

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Additional Keywords : Risk Reduction

[+]

Nobiletin can specifically improve memories of emotionally salient information associated with fear and novelty.Nov 08, 2016

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Pubmed Data : J Nat Med. 2016 Nov 9. Epub 2016 Nov 9. PMID: 27830412

Article Published Date : Nov 08, 2016

Study Type : Animal Study

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Substances : Nobiletin

Diseases : Psychiatric Disorder: Conditioned Fear

[+]

Nobiletin clearly restored the alveolar bone mass in a mouse experimental model for periodontitis by inhibiting LPS-induced bone resorption.Dec 31, 2011

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The anti-neoplastic activity of nobiletin was due to its ability to inhibit angiogenesisMay 31, 2015

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Pubmed Data : Int J Oncol. 2015 Jun ;46(6):2629-38. Epub 2015 Apr 1. PMID: 25845666

Article Published Date : May 31, 2015

Study Type : Animal Study

Additional Links

Substances : Nobiletin

Diseases : Ovarian Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Hypoxia-inducible factor-1 (HIF-1) inhibitor, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors

[+]

The biological clock enhancer nobiletin ameliorates steatosis in obesity by restoring aberrant hepatic circadian rhythm.Aug 22, 2022

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Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2022 Aug 23. Epub 2022 Aug 23. PMID: 35997288

Article Published Date : Aug 22, 2022

Study Type : Animal Study

Additional Links

Substances : Nobiletin

Diseases : Circadian Dysregulation, Nonalcoholic fatty liver disease (NAFLD), Obesity

Pharmacological Actions : Hepatoprotective

Additional Keywords : Circadian Rhythm

[+]

The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat fed- mice independent of AMPK.Jan 20, 2020

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Pubmed Data : Nutrients. 2020 Sep 23 ;12(10). Epub 2020 Sep 23. PMID: 32977511

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Nobiletin alleviates astrocyte activation and oxidative stress induced by hypoxia.Mar 16, 2022

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Pubmed Data : Molecules. 2022 Mar 17 ;27(6). Epub 2022 Mar 17. PMID: 35335325

Article Published Date : Mar 16, 2022

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Brain: Oxidative Stress, Hypoxia: Brain

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation

[+]

Nobiletin alleviates the hypoxia/reoxygenation-induced damage in myocardial cells.Jun 25, 2021

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Pubmed Data : J Food Biochem. 2021 Jun 26:e13844. Epub 2021 Jun 26. PMID: 34173673

Article Published Date : Jun 25, 2021

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Myocardial Ischemia

Pharmacological Actions : Anti-Apoptotic, Cardioprotective

[+]

Nobiletin and EGCG are good candidates for preventing diseases caused by excessive fructose intake.Nov 30, 2017

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Pubmed Data : Biosci Biotechnol Biochem. 2017 Dec 1:1-11. Epub 2017 Dec 1. PMID: 29191128

Article Published Date : Nov 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : EGCG (Epigallocatechin gallate), Nobiletin

Diseases : High Fructose Diet

[+]

Nobiletin and tangeretin may be beneficial in the treatment and prevention of Alzheimer`s and Parkinson's disease.Mar 26, 2017

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Biomed Pharmacother. 2018 Apr 7 ;103:29-37. Epub 2018 Apr 7. PMID: 29635125

Article Published Date : Apr 06, 2018

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Cancers: Multi-Drug Resistant, Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic, P21 Activation, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Selective Antiproliferation

[+]

Nobiletin decreases inflammatory mediator expression in tumor necrosis factor-stimulated human periodontal ligament cells.Dec 31, 2020

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Pubmed Data : Nutrients. 2018 Nov 26 ;10(12). Epub 2018 Nov 26. PMID: 30486290

Article Published Date : Nov 25, 2018

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

[+]

Nobiletin exhibited memory-improving effects in various animal models of dementia and exerted a wide range of beneficial effects against pathological features of AD.Jul 31, 2014

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Pubmed Data : J Environ Pathol Toxicol Oncol. 2020 ;39(1):77-88. PMID: 32479014

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Gastric Cancer, Helicobacter Pylori Infection

Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Click here to read the entire abstract

Pubmed Data : Biochem Biophys Res Commun. 2019 Jan 1 ;508(1):97-101. Epub 2018 Nov 22. PMID: 30471854

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Atherosclerosis, Cardiovascular Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic, MicroRNA modulator

[+]

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View the Evidence: 184 Abstracts with Nobiletin Research

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Potential of nobiletin against Alzheimer's disease through inhibiting neuroinflammation.Mar 09, 2022

Perilla seed oil in combination with nobiletin-rich ponkan powder enhances cognitive function in healthy elderly Japanese individuals.Feb 15, 2022

Nobiletin appears to be a promising novel prophylactic seed drug or functional food for Alzheimer's disease.Dec 31, 2017

Nobiletin could alleviate iron overload damage in vascular endothelium.Jan 29, 2020

Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes.Mar 26, 2020

These data suggest that nobiletin might be a potential antithrombotic agent of dietary origin.Mar 14, 2017

Nobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion.May 03, 2022

Nobiletin protects retinal ganglion cells in models of ocular hypertension.Jul 07, 2022

ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer.Apr 18, 2022

Ameliorating effect of Citrus aurantium extracts and nobiletin on β‑amyloid (1‑42)‑induced memory impairment.Aug 08, 2019

Analgesic effect of nobiletin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve.Aug 31, 2022

Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency.Dec 31, 2021

Bidirectional interaction of nobiletin and gut microbiota in mice fed with a high-fat diet.Apr 25, 2021

Combinations of nobiletin with paclitaxel and carboplatin significantly suppressed the growth of subcutaneous A549 tumors xenografts in nude mice.Mar 31, 2014

Effects of the clock modulator nobiletin on circadian rhythms and pathophysiology in female mice of an Alzheimer's disease model.Jul 08, 2021

Endothelium-independent vasodilator effects of nobiletin in rat aorta.Apr 30, 2019

Flavonoid nobiletin attenuates cyclophosphamide-induced cystitis.Apr 30, 2022

In vitro and In vivo effects of nobiletin on DRG neurite elongation and axon growth after sciatic nerve injury.Aug 25, 2021

Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in animals.Aug 31, 2018

Long-term dietary supplementation with low-dose nobiletin ameliorates hepatic steatosis, insulin resistance, and inflammation.Jul 31, 2017

Nobiletin alleviates cerebral ischemic-reperfusion injury via MAPK signaling pathway.Dec 31, 2018

Nobiletin alleviates ferroptosis-associated renal injury, inflammation, and fibrosis.Mar 02, 2022

Nobiletin alleviates high-fat diet-induced nonalcoholic fatty liver disease.Oct 19, 2020

Nobiletin alleviates ischemia/reperfusion injury in the kidney by activating PI3K/AKT pathway.Nov 30, 2020

Nobiletin alleviates non-alcoholic steatohepatitis.Dec 31, 2020

Nobiletin ameliorates cardiac impairment and alleviates cardiac remodeling after acute myocardial infarction.Dec 31, 2020

Nobiletin ameliorates myocardial ischemia and reperfusion injury.May 09, 2019

Nobiletin ameliorates streptozotocin-cadmium-induced diabetic nephropathy via NF-κB signalling pathway.Aug 03, 2021

Nobiletin ameliorates the cardiovascular dysfunction of diabetes by inhibiting oxidative stress, MMP-2 and MMP-9.Jul 12, 2016

Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis.Mar 31, 2017

Nobiletin and tangeretin may ameliorate scratching behavioral reactions by inhibiting the action of histamineOct 31, 2013

Nobiletin attenuates acetaminophen-induced hepatorenal toxicity.Nov 26, 2019

Nobiletin attenuates adverse cardiac remodeling after acute myocardial infarction in rats.Aug 18, 2017

Nobiletin attenuates cardiac dysfunction, oxidative stress, and inflammatory in streptozotocin: induced diabetic cardiomyopathy.May 31, 2016

Nobiletin attenuates inflammation via modulating proinflammatory and antiinflammatory cytokine expressions in an autoimmune encephalomyelitis.Dec 08, 2021

Nobiletin attenuates pathological cardiac remodeling after myocardial infarction.Dec 31, 2020

Nobiletin can ameliorate ischemia-reperfusion injury after liver transplantation.Apr 30, 2017

Nobiletin can specifically improve memories of emotionally salient information associated with fear and novelty.Nov 08, 2016

Nobiletin clearly restored the alveolar bone mass in a mouse experimental model for periodontitis by inhibiting LPS-induced bone resorption.Dec 31, 2011

Nobiletin could be used as a potential therapeutic to counter the nonylphenol-prompted oxidative stress and apoptotic damages in testes.Aug 19, 2020

Nobiletin could be used as an intervention that enhances circadian rhythms to combat metabolic disease via the circadian gene network.Apr 11, 2016

Nobiletin could significantly suppress the high blood glucose.May 17, 2022

Nobiletin decreases inflammatory symptoms and markers in murine colitis.Mar 09, 2018

Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge.Aug 27, 2019

Nobiletin has an anticell proliferative effect on DMBA-induced mammary cancer.Dec 31, 2019

Nobiletin has gastroprotective effects against ethanol-induced acute gastric lesions.Sep 25, 2017

Nobiletin has potential application in extension of lifespan.Jan 03, 2020

Nobiletin has shown that it has protective effects by reducing kidney damage caused by ischemia-reperfusion injury.Nov 07, 2019

Nobiletin improves propofol-induced neuroprotection in ischemic brain injury.Dec 31, 2016

Nobiletin may be a potential therapeutic agent for the treatment of osteoarthritis.Dec 31, 2018

Nobiletin may have potential use as a chemopreventive agent against nasopharyngeal cancer metastasis.Feb 28, 2015

Nobiletin may serve as a potential approach to alleviate neuroinflammation-related diseases.May 07, 2019

Nobiletin may serve as a potential therapeutic agent for the treatment of HCD-induced hypercholesterolemia and NAFLD.Jul 31, 2021

Nobiletin might be a novel and promising agent for treatment of NASH and liver fibrosis.Oct 21, 2021

Nobiletin might have a great potential for treating glioblastoma.Apr 30, 2017

Nobiletin mitigates NAFLD via lipophagy and inflammation.Oct 02, 2022

Nobiletin prevents against acute liver injury.Jun 13, 2020

Nobiletin prevents amyloid β 1-40-induced cognitive impairment via inhibition of neuroinflammation and oxidative/nitrosative stress.Mar 15, 2022

Nobiletin prevents high-fat diet-induced dysregulation of intestinal lipid metabolism.Dec 15, 2021

Nobiletin prevents memory impairment and exhibits a protecting action against neurodgeneration in a alzheimer's disease model.Dec 31, 2014

Nobiletin protects against cardiac hypertrophy induced by pressure-overload.Jul 12, 2017

Nobiletin protects against diabetes-induced testicular injury.Oct 27, 2021

Nobiletin protects against myocardial injury and myocardial apoptosis following coronary microembolization.May 08, 2019

Nobiletin protects enteric nerves and ameliorates disordered bowel motility in diet-induced obesity.Oct 04, 2022

Nobiletin reduced the levels of soluble Aβ1-40 in the brain of 3XTg-AD mice and reduced ROS levels in the hippocampus of 3XTg-AD as well as wild-type mice.Jul 31, 2015

Nobiletin rescues motor and cognitive dysfunction in a MPTP-induced Parkinson model mice, in part by enhancing dopamine release.Feb 13, 2014

Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats.Jan 02, 2022

Nobiletin restored intestinal barrier function, which had been damaged after TNBS administration, through the inhibition of the Akt-NF-κB-MLCK pathway.Apr 30, 2015

Nobiletin restores reduced mitochondrial metabolism in hypothyroid rat hippocampus through acceleration of matrix substrate-level phosphorylation.Mar 16, 2014

Nobiletin reversed paclitaxel resistance in multi-drug resistance tumors.Nov 25, 2019

Nobiletin supplementation inhibited activation of apoptotic pathways and DNA damage.May 18, 2015

Nobiletin treatment ameliorated motor functional deficits in the ischemic rats compared with those deficits of the vehicle-treated group.Apr 21, 2014

Nobiletin

View the Evidence:
184 Abstracts with Nobiletin Research