Nobiletin

Name	AC	CK
Cognitive Decline/Dysfunction	5	9
Inflammation	6	9
Alzheimer's Disease	5	7
Neurodegenerative Diseases	4	7
Oxidative Stress	3	7
Colitis	3	6
Colon Cancer	4	6
Cholesterol: Oxidation	1	5
Parkinson's Disease	3	5
Dementia	3	4
Diabetic Complications	2	4
Lipopolysaccharide-Induced Toxicity	2	4
Lung Cancer	2	3
Alcohol Toxicity	1	2
Allergies	1	2
Brain Edema	1	2
Brain Inflammation	1	2
Brain Ischemia	1	2
Breast Cancer	2	2
Cancers: All	2	2
Cancers: Multi-Drug Resistant	2	2
Carcinoma: Non-Small-Cell Lung	1	2
Cardiac Hypertrophy	1	2
Cardiomyopathy	1	2
Cardiovascular Diseases	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Colon Cancer: Prevention	1	2
DNA damage	1	2
Diabetes Mellitus: Type 1	1	2
Dyslipidemias	1	2
Fibrosis	1	2
Gastric Ulcer	1	2
Glioblastoma	1	2
High Fat Diet	1	2
Histamine: Elevated	1	2
Hypothyroidism	1	2
Insulin Resistance	1	2
Intestinal Permeability	1	2
Itching	1	2
Liver Injury: Ischemia/reperfusion	1	2
Metabolic Diseases	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Myocardial Infarction	1	2
Nasopharyngeal Cancer	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Organ Transplantation: Liver	1	2
Osteoporosis	1	2
Ovarian Cancer	1	2
Parkinsonian Disorders	1	2
Periodontitis	1	2
Psychiatric Disorder: Conditioned Fear	1	2
Rheumatoid Arthritis	1	2
Stroke: Attenuation/Recovery	1	2
Stroke: Ischemic	1	2
Thyroid Diseases	1	2
Cancer Metastasis	1	1
Cancers: Drug Resistant	1	1
Chikungunya Virus	1	1
Colorectal Cancer	1	1
Endothelial Dysfunction	1	1
Gastric Cancer	1	1
Glioblastoma Multiforme	1	1
Hepatitis C	1	1
High Fructose Diet	1	1
Hypertension	1	1
Learning disorders	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Neurologic Disorders	1	1
Obesity	1	1
Osteosarcoma	1	1
Preterm Birth: Prevention	1	1
Skin Cancer	1	1
Skin Cancer: Prevention	1	1

Name	AC	CK
Anti-Inflammatory Agents	14	24
Neuroprotective Agents	13	21
Antioxidants	13	20
NF-kappaB Inhibitor	4	11
Antiproliferative	7	10
Tumor Necrosis Factor (TNF) Alpha Inhibitor	6	10
Anti-metastatic	6	8
Apoptotic	6	8
Chemopreventive	5	8
Anti-Apoptotic	3	6
Hepatoprotective	3	6
Anticarcinogenic Agents	3	5
Antithrombotic	1	5
Cardioprotective	3	5
Cardiovascular Agents	1	5
Interleukin-1 beta downregulation	3	5
Interleukin-6 Downregulation	3	5
Matrix metalloproteinase-2 (MMP-2) inhibitor	3	5
Angiogenesis Inhibitors	3	4
Cell cycle arrest	3	4
Cyclooxygenase 2 Inhibitors	3	4
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	4
Antineoplastic Agents	2	3
Heme oxygenase-1 inducer	2	3
Nitric Oxide Inhibitor	2	3
Anti-Allergic Agents	1	2
Antiviral Agents	2	2
Chemoprotective Agents	1	2
Chemosensitizer	2	2
Chemotherapeutic	2	2
Gastroprotective	1	2
Hypoxia-inducible factor-1 (HIF-1) inhibitor	1	2
Interleukin-4 downregulation	1	2
MicroRNA modulator	2	2
Nrf2 activation	1	2
Renoprotective	1	2
Vascular Endothelial Growth Factor Inhibitors	1	2
Antihypertensive Agents	1	1
Aromatase Inhibitors	1	1
Caspase-3 Activation	1	1
Cyclin D1 Down-Regulation	1	1
E-cadherin down-regulation	1	1
Enzyme Inhibitors	1	1
Interleukin-8 downregulation	1	1
Multidrug Resistance Gene Modulators	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
Prostaglandin PGE2 downregulation	1	1
Vasodilator Agents	1	1

[+]

Nobiletin appears to be a promising novel prophylactic seed drug or functional food for Alzheimer's disease.Dec 31, 2017

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Pubmed Data : Biol Pharm Bull. 2018 ;41(4):451-457. PMID: 29607920

Endothelium-independent vasodilator effects of nobiletin in rat aorta.Apr 30, 2019

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Pubmed Data : J Pharmacol Sci. 2019 May ;140(1):48-53. Epub 2019 Apr 17. PMID: 31088764

Article Published Date : Apr 30, 2019

Study Type : Animal Study

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Substances : Nobiletin

Pharmacological Actions : Vasodilator Agents

[+]

Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in animals.Aug 31, 2018

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Pubmed Data : J Lipid Res. 2018 Sep ;59(9):1714-1728. Epub 2018 Jul 15. PMID: 30008441

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Pubmed Data : J Nutr Biochem. 2020 Oct 20 ;87:108526. Epub 2020 Oct 20. PMID: 33096235

Article Published Date : Oct 19, 2020

Study Type : Animal Study

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Substances : Nobiletin

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antihypertensive Agents, Hypolipidemic

[+]

Nobiletin alleviates ischemia/reperfusion injury in the kidney by activating PI3K/AKT pathway.Nov 30, 2020

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Pubmed Data : Biochem Biophys Res Commun. 2017 Aug 19. Epub 2017 Aug 19. PMID: 28830813

Article Published Date : Aug 18, 2017

Study Type : Animal Study

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Substances : Nobiletin

Diseases : Myocardial Infarction

Pharmacological Actions : Cardioprotective

[+]

Nobiletin attenuates cardiac dysfunction, oxidative stress, and inflammatory in streptozotocin: induced diabetic cardiomyopathy.May 31, 2016

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Pubmed Data : Mol Cell Biochem. 2016 Jun ;417(1-2):87-96. Epub 2016 May 10. PMID: 27160937

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Pubmed Data : Phytomedicine. 2013 Jun 15 ;20(8-9):743-52. Epub 2013 Mar 26. PMID: 23537747

Article Published Date : Jun 14, 2013

Study Type : In Vitro Study

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Substances : Nobiletin

Diseases : Cancer Metastasis, Liver Cancer

Pharmacological Actions : Anti-metastatic

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Nobiletin selectively inhibits oral cancer cell growth by promoting apoptosis and DNA damage in vitro.Jul 03, 2020

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Pubmed Data : Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Jul 4. Epub 2020 Jul 4. PMID: 32868254

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Pubmed Data : J Agric Food Chem. 2020 Apr 22 ;68(16):4641-4649. Epub 2020 Apr 13. PMID: 32249565

Article Published Date : Apr 21, 2020

Study Type : In Vitro Study

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Substances : Nobiletin

Diseases : Colitis

Pharmacological Actions : Gastroprotective

[+]

Nobiletin attenuates neurotoxic mitochondrial calcium overload.Apr 30, 2018

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Pubmed Data : Biomed Pharmacother. 2018 Apr 7 ;103:29-37. Epub 2018 Apr 7. PMID: 29635125

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Pubmed Data : Nutrients. 2018 Nov 26 ;10(12). Epub 2018 Nov 26. PMID: 30486290

Article Published Date : Nov 25, 2018

Study Type : In Vitro Study

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Substances : Nobiletin

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

[+]

Nobiletin exhibited memory-improving effects in various animal models of dementia and exerted a wide range of beneficial effects against pathological features of AD.Jul 31, 2014

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Pubmed Data : Biomedicines. 2020 May 5 ;8(5). Epub 2020 May 5. PMID: 32380783

Article Published Date : May 04, 2020

Study Type : In Vitro Study

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Substances : Nobiletin

Diseases : Cancers: All

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, NF-kappaB Inhibitor, STAT3 Inhibitor, Transforming growth factor beta (TGF-β) inhibitor

[+]

Nobiletin induced apoptosis in SNU-16 cellsJul 13, 2016

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Pubmed Data : Food Nutr Res. 2018 ;62. Epub 2018 Nov 21. PMID: 30574046

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

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Substances : Nobiletin

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Nobiletin inhibits cell growth through restraining aerobic glycolysis via PKA-CREB pathway in oral squamous cell carcinoma.Jun 30, 2020

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Pubmed Data : Exp Ther Med. 2018 Aug ;16(2):1470-1476. Epub 2018 Jun 20. PMID: 30116396

Article Published Date : Jul 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Cerebral Ischemia

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

[+]

Nobiletin reduced anaplastic thyroid cancer cell viability as efficiently as conventional drugs.Jul 08, 2019

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Pubmed Data : Nutr Cancer. 2019 Jul 9:1-12. Epub 2019 Jul 9. PMID: 31287730

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Pubmed Data : J Biochem Mol Toxicol. 2018 Apr 24:e22052. Epub 2018 Apr 24. PMID: 29687528

Article Published Date : Apr 23, 2018

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Hydrogen Peroxide Induced Toxicity, Macular Degeneration

Pharmacological Actions : Antioxidants

[+]

Nobiletin significantly reversed ABCB1 mediated multidrug resistance in cancer cells. Dec 31, 2014

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Pubmed Data : Sci Rep. 2015 ;5:18789. Epub 2015 Dec 22. PMID: 26689156

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View the Evidence: 127 Abstracts with Nobiletin Research

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Nobiletin appears to be a promising novel prophylactic seed drug or functional food for Alzheimer's disease.Dec 31, 2017

Nobiletin could alleviate iron overload damage in vascular endothelium.Jan 29, 2020

Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes.Mar 26, 2020

These data suggest that nobiletin might be a potential antithrombotic agent of dietary origin.Mar 14, 2017

Ameliorating effect of Citrus aurantium extracts and nobiletin on β‑amyloid (1‑42)‑induced memory impairment.Aug 08, 2019

Combinations of nobiletin with paclitaxel and carboplatin significantly suppressed the growth of subcutaneous A549 tumors xenografts in nude mice.Mar 31, 2014

Endothelium-independent vasodilator effects of nobiletin in rat aorta.Apr 30, 2019

Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in animals.Aug 31, 2018

Long-term dietary supplementation with low-dose nobiletin ameliorates hepatic steatosis, insulin resistance, and inflammation.Jul 31, 2017

Nobiletin alleviates cerebral ischemic-reperfusion injury via MAPK signaling pathway.Dec 31, 2018

Nobiletin alleviates high-fat diet-induced nonalcoholic fatty liver disease.Oct 19, 2020

Nobiletin alleviates ischemia/reperfusion injury in the kidney by activating PI3K/AKT pathway.Nov 30, 2020

Nobiletin ameliorates myocardial ischemia and reperfusion injury.May 09, 2019

Nobiletin ameliorates the cardiovascular dysfunction of diabetes by inhibiting oxidative stress, MMP-2 and MMP-9.Jul 12, 2016

Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis.Mar 31, 2017

Nobiletin and tangeretin may ameliorate scratching behavioral reactions by inhibiting the action of histamineOct 31, 2013

Nobiletin attenuates acetaminophen-induced hepatorenal toxicity.Nov 26, 2019

Nobiletin attenuates adverse cardiac remodeling after acute myocardial infarction in rats.Aug 18, 2017

Nobiletin attenuates cardiac dysfunction, oxidative stress, and inflammatory in streptozotocin: induced diabetic cardiomyopathy.May 31, 2016

Nobiletin can ameliorate ischemia-reperfusion injury after liver transplantation.Apr 30, 2017

Nobiletin can specifically improve memories of emotionally salient information associated with fear and novelty.Nov 08, 2016

Nobiletin clearly restored the alveolar bone mass in a mouse experimental model for periodontitis by inhibiting LPS-induced bone resorption.Dec 31, 2011

Nobiletin could be used as a potential therapeutic to counter the nonylphenol-prompted oxidative stress and apoptotic damages in testes.Aug 19, 2020

Nobiletin could be used as an intervention that enhances circadian rhythms to combat metabolic disease via the circadian gene network.Apr 11, 2016

Nobiletin decreases inflammatory symptoms and markers in murine colitis.Mar 09, 2018

Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge.Aug 27, 2019

Nobiletin has an anticell proliferative effect on DMBA-induced mammary cancer.Dec 31, 2019

Nobiletin has gastroprotective effects against ethanol-induced acute gastric lesions.Sep 25, 2017

Nobiletin has potential application in extension of lifespan.Jan 03, 2020

Nobiletin has shown that it has protective effects by reducing kidney damage caused by ischemia-reperfusion injury.Nov 07, 2019

Nobiletin improves propofol-induced neuroprotection in ischemic brain injury.Dec 31, 2016

Nobiletin may be a potential therapeutic agent for the treatment of osteoarthritis.Dec 31, 2018

Nobiletin may have potential use as a chemopreventive agent against nasopharyngeal cancer metastasis.Feb 28, 2015

Nobiletin may serve as a potential approach to alleviate neuroinflammation-related diseases.May 07, 2019

Nobiletin might have a great potential for treating glioblastoma.Apr 30, 2017

Nobiletin prevents against acute liver injury.Jun 13, 2020

Nobiletin prevents memory impairment and exhibits a protecting action against neurodgeneration in a alzheimer's disease model.Dec 31, 2014

Nobiletin protects against cardiac hypertrophy induced by pressure-overload.Jul 12, 2017

Nobiletin protects against myocardial injury and myocardial apoptosis following coronary microembolization.May 08, 2019

Nobiletin reduced the levels of soluble Aβ1-40 in the brain of 3XTg-AD mice and reduced ROS levels in the hippocampus of 3XTg-AD as well as wild-type mice.Jul 31, 2015

Nobiletin rescues motor and cognitive dysfunction in a MPTP-induced Parkinson model mice, in part by enhancing dopamine release.Feb 13, 2014

Nobiletin restored intestinal barrier function, which had been damaged after TNBS administration, through the inhibition of the Akt-NF-κB-MLCK pathway.Apr 30, 2015

Nobiletin restores reduced mitochondrial metabolism in hypothyroid rat hippocampus through acceleration of matrix substrate-level phosphorylation.Mar 16, 2014

Nobiletin reversed paclitaxel resistance in multi-drug resistance tumors.Nov 25, 2019

Nobiletin supplementation inhibited activation of apoptotic pathways and DNA damage.May 18, 2015

Nobiletin treatment ameliorated motor functional deficits in the ischemic rats compared with those deficits of the vehicle-treated group.Apr 21, 2014

Nobiletin-loaded micelles reduce ovariectomy-induced bone loss by suppressing osteoclastogenesis.Dec 31, 2018

Oral administration of nobiletin significantly inhibited colitis-associated colon carcinogenesis in mice.Sep 09, 2015

Supplementation with nobiletin may protect against the neurodegeneration involved in PD. Mar 31, 2015

Tangerine peel possesses potent anti-neuroinflammatory capacity which is attributed to the collective effect of hesperidin, nobiletin, and tangeretin.Aug 31, 2014

The anti-neoplastic activity of nobiletin was due to its ability to inhibit angiogenesisMay 31, 2015

The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat fed- mice independent of AMPK.Jan 20, 2020

The observations of this study indicate protective effects of nobiletin against cadmium-induced neurotoxicity.Jan 15, 2018

These findings provide support for the molecular mechanisms underlying the effects of nobiletin treatment on isoflurane-induced damage.Oct 31, 2016

These findings support the potential for nobiletin as a therapeutic agent for the treatment of acute liver injury.Nov 14, 2016

These results demonstrated that nobiletin inhibited the development of rheumatoid arthritis.Nov 20, 2017

These results suggest that nobiletin attenuates high fat diet-induced vascular and renal alterations.Sep 09, 2020

This study provides the first evidence that nobiletin exert protection on endometriosis.Jun 04, 2018

Nobiletin affects circadian rhythms and oncogenic characteristics in a cell-dependent manner.Dec 31, 2019

Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells.Jun 14, 2013

Nobiletin selectively inhibits oral cancer cell growth by promoting apoptosis and DNA damage in vitro.Jul 03, 2020

Citrus flavonoids as a target for the prevention of pancreatic β-cells dysfunction in diabetes.Dec 31, 2019

Citrus flavonoids as promising phytochemicals targeting diabetes and related complications.Sep 22, 2020

Citrus peel flavonoids improve lipid metabolism by inhibiting miR-33 and miR-122 expression in HepG2 cells.Apr 23, 2019

Citrus unshiu peel and its active ingredient nobiletin exhibit anti-hepatitis C activity.Jan 01, 2005

Discovery of nobiletin from citrus peel as a potent inhibitor of β-amyloid peptide toxicity.Nov 03, 2019

Downregulation of Notch-1 and reexpression of miR-200b by nobiletin might be a novel remedy for the therapy of lung cancer.Mar 31, 2015

Evaluation of the effects of nobiletin on toll-like receptor 3 signalling pathways in prostate cancer. Oct 28, 2020

Inhibitory effects of nobiletin and its major metabolites on lung tumorigenesis.Oct 29, 2019

Nchinpi extracts potently facilitated CRE-mediated transcription in cultured hippocampal neurons.Sep 30, 2013

Nobiletin and EGCG are good candidates for preventing diseases caused by excessive fructose intake.Nov 30, 2017

Nobiletin and tangeretin may be beneficial in the treatment and prevention of Alzheimer`s and Parkinson's disease.Mar 26, 2017

Nobiletin

View the Evidence:
127 Abstracts with Nobiletin Research