Nobiletin

Name	AC	CK
Alzheimer's Disease	9	16
Inflammation	8	12
Cognitive Decline/Dysfunction	5	9
Colitis	5	9
High Fat Diet	4	8
Oxidative Stress	4	8
Neurodegenerative Diseases	4	7
Colon Cancer	4	6
Nonalcoholic fatty liver disease (NAFLD)	4	6
Obesity	4	6
Parkinson's Disease	4	6
Brain Inflammation	3	5
Breast Cancer	5	5
Cancers: Multi-Drug Resistant	4	5
Cholesterol: Oxidation	1	5
Diabetic Complications	3	5
Gestational Diabetes	1	5
Iron Overload	1	5
Lipopolysaccharide-Induced Toxicity	3	5
Lung Cancer	3	5
Aging	2	4
Cancers: All	4	4
Carcinoma: Non-Small-Cell Lung	3	4
Chemically-Induced Liver Damage	2	4
Colorectal Cancer	4	4
Dementia	3	4
Dyslipidemias	2	4
Insulin Resistance	2	4
Ischemia	2	4
Kidney Damage	2	4
Osteoporosis	2	4
Ovarian Cancer	3	4
Atherosclerosis	2	3
Cancer Metastasis	3	3
Cardiovascular Diseases	2	3
Cerebral Ischemia	2	3
Liver Injury: Ischemia/reperfusion	2	3
Myocardial Ischemia	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Alcohol Toxicity	1	2
Allergies	1	2
Brain Edema	1	2
Brain Ischemia	1	2
Breast Cancer: Chemically-Induced	1	2
Cadmium Poisoning	1	2
Cardiac Hypertrophy	1	2
Cardiomyopathy	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Colon Cancer: Prevention	1	2
Coronary Artery Disease	1	2
DNA damage	1	2
Diabetes Mellitus: Type 1	1	2
Endometriosis	1	2
Fibrosis	1	2
Gastric Cancer	2	2
Gastric Ulcer	1	2
Glioblastoma	1	2
Hepatic Steatosis	1	2
Histamine: Elevated	1	2
Hypothyroidism	1	2
Intestinal Permeability	1	2
Itching	1	2
Kidney Cancer	2	2
Kidney Damage: Drug-Induced	1	2
Metabolic Diseases	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Myocardial Infarction	1	2
Nasopharyngeal Cancer	1	2
Oral Cancer	2	2
Organ Transplantation: Liver	1	2
Osteoarthritis	1	2
Parkinsonian Disorders	1	2
Periodontitis	1	2
Prostate Cancer	2	2
Psychiatric Disorder: Conditioned Fear	1	2
Rheumatoid Arthritis	1	2
Stroke: Attenuation/Recovery	1	2
Stroke: Ischemic	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Thyroid Diseases	1	2
Acute Myeloid Leukemia	1	1
Arterial Calcification	1	1
Bladder Cancer	1	1
Breast Cancer: Triple Negative	1	1
Cancers: Drug Resistant	1	1
Chikungunya Virus	1	1
Chronic Myeloid Leukemia	1	1
Depression	1	1
Diabetes Mellitus: Type 2	1	1
Diabetic Nephropathy	1	1
Endothelial Dysfunction	1	1
Glioblastoma Multiforme	1	1
Heart Disease	1	1
Helicobacter Pylori Infection	1	1
Hepatitis B	1	1
Hepatitis C	1	1
High Fructose Diet	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Hypercalcemia	1	1
Hypertension	1	1
Hypoxia	1	1
Learning disorders	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Leukemia: Chronic myelogenous leukemia (CML)	1	1
Liver Cancer	1	1
Lung Injury: Acute	1	1
Macular Degeneration	1	1
Neurologic Disorders	1	1
Osteosarcoma	1	1
Pancreatic Cancer	1	1
Periodontal Diseases	1	1
Preterm Birth: Prevention	1	1
Skin Cancer	1	1
Skin Cancer: Prevention	1	1
Squamous cell carcinoma	1	1
Thyroid Cancer	1	1

Name	AC	CK
Anti-Inflammatory Agents	32	54
Antioxidants	25	43
Neuroprotective Agents	19	34
Antiproliferative	23	27
Tumor Necrosis Factor (TNF) Alpha Inhibitor	15	24
NF-kappaB Inhibitor	12	21
Anti-Apoptotic	12	20
Apoptotic	15	17
Interleukin-6 Downregulation	10	16
Interleukin-1 beta downregulation	9	14
Hepatoprotective	8	13
Anti-metastatic	10	12
Chemopreventive	9	12
Cardioprotective	7	11
Renoprotective	6	11
Chemotherapeutic	8	9
Hypolipidemic	6	9
Cell cycle arrest	7	8
Chemosensitizer	7	8
Cyclooxygenase 2 Inhibitors	6	8
Anticarcinogenic Agents	4	6
Hypoglycemic Agents	2	6
Matrix metalloproteinase-2 (MMP-2) inhibitor	4	6
Angiogenesis Inhibitors	4	5
Antithrombotic	1	5
Cardiovascular Agents	1	5
Matrix metalloproteinase-9 (MMP-9) inhibitor	4	5
Nitric Oxide Enhancer	1	5
Prophylactic Agents	1	5
Antineoplastic Agents	3	4
MicroRNA modulator	4	4
Nitric Oxide Inhibitor	3	4
Antihypertensive Agents	2	3
Antiviral Agents	3	3
Gastroprotective	2	3
Heme oxygenase-1 inducer	2	3
Vasodilator Agents	2	3
Anti-Allergic Agents	1	2
Chemoprotective Agents	1	2
Cyclin D1 Down-Regulation	2	2
Hypoxia-inducible factor-1 (HIF-1) inhibitor	1	2
Interleukin-10 upregulation	1	2
Interleukin-4 downregulation	1	2
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	2
Nrf2 activation	1	2
Osteoprotective	1	2
P21 Activation	2	2
Vascular Endothelial Growth Factor Inhibitors	1	2
Wnt/β-catenin signaling pathway modulation	2	2
Antidepressive Agents	1	1
Aromatase Inhibitors	1	1
Autophagy Inhibitors	1	1
Autophagy Up-regulation	1	1
Bcl-2 protein down-regulation	1	1
Bcl-xL down-regulation	1	1
Caspase-3 Activation	1	1
E-cadherin down-regulation	1	1
Enzyme Inhibitors	1	1
Interleukin-18 down-regulation	1	1
Interleukin-8 downregulation	1	1
Multidrug Resistance Gene Modulators	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
Pancreato Protective Agents	1	1
Postaglandin PGE2 downregulation	1	1
Prostaglandin PGE2 downregulation	1	1
STAT3 Inhibitor	1	1
Transforming growth factor beta (TGF-β) inhibitor	1	1
Tumor Suppressor Protein p53 Upregulation	1	1

[+]

Nobiletin appears to be a promising novel prophylactic seed drug or functional food for Alzheimer's disease.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biol Pharm Bull. 2018 ;41(4):451-457. PMID: 29607920

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Pubmed Data : Biomolecules. 2021 Jul 9 ;11(7). Epub 2021 Jul 9. PMID: 34356628

Article Published Date : Jul 08, 2021

Study Type : Animal Study

Additional Links

Substances : Nobiletin

Diseases : Alzheimer's Disease, Circadian Dysregulation

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Gene Expression Regulation

[+]

Endothelium-independent vasodilator effects of nobiletin in rat aorta.Apr 30, 2019

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Pubmed Data : J Pharmacol Sci. 2019 May ;140(1):48-53. Epub 2019 Apr 17. PMID: 31088764

Article Published Date : Apr 30, 2019

Study Type : Animal Study

Additional Links

Substances : Nobiletin

Pharmacological Actions : Vasodilator Agents

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In vitro and In vivo effects of nobiletin on DRG neurite elongation and axon growth after sciatic nerve injury.Aug 25, 2021

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Pubmed Data : Int J Environ Res Public Health. 2021 Aug 26 ;18(17). Epub 2021 Aug 26. PMID: 34501579

Article Published Date : Aug 25, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Sciatic Nerve Crush Injury

Pharmacological Actions : Neuroprotective Agents, Regenerative

Additional Keywords : Nerve Regeneration

[+]

Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in animals.Aug 31, 2018

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Pubmed Data : J Lipid Res. 2018 Sep ;59(9):1714-1728. Epub 2018 Jul 15. PMID: 30008441

The anti-neoplastic activity of nobiletin was due to its ability to inhibit angiogenesisMay 31, 2015

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Pubmed Data : Nutrients. 2020 Sep 23 ;12(10). Epub 2020 Sep 23. PMID: 32977511

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Nobiletin attenuated hypoxia-induced apoptosis in JEG-3 and BeWo cell lines.Dec 31, 2020

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Pubmed Data : Biomed Pharmacother. 2018 Apr 7 ;103:29-37. Epub 2018 Apr 7. PMID: 29635125

Article Published Date : Apr 06, 2018

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Cancers: Multi-Drug Resistant, Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic, P21 Activation, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Selective Antiproliferation

[+]

Nobiletin decreases inflammatory mediator expression in tumor necrosis factor-stimulated human periodontal ligament cells.Dec 31, 2020

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Pubmed Data : Nutrients. 2018 Nov 26 ;10(12). Epub 2018 Nov 26. PMID: 30486290

Article Published Date : Nov 25, 2018

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

[+]

Nobiletin exhibited memory-improving effects in various animal models of dementia and exerted a wide range of beneficial effects against pathological features of AD.Jul 31, 2014

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Pubmed Data : Biomedicines. 2020 May 5 ;8(5). Epub 2020 May 5. PMID: 32380783

Article Published Date : May 04, 2020

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Cancers: All

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, NF-kappaB Inhibitor, STAT3 Inhibitor, Transforming growth factor beta (TGF-β) inhibitor

[+]

Nobiletin induced apoptosis in SNU-16 cellsJul 13, 2016

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Pubmed Data : Food Nutr Res. 2018 ;62. Epub 2018 Nov 21. PMID: 30574046

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Nobiletin inhibits cell growth through restraining aerobic glycolysis via PKA-CREB pathway in oral squamous cell carcinoma.Jun 30, 2020

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Pubmed Data : J Environ Pathol Toxicol Oncol. 2020 ;39(1):77-88. PMID: 32479014

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Gastric Cancer, Helicobacter Pylori Infection

Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Click here to read the entire abstract

Pubmed Data : Biochem Biophys Res Commun. 2019 Jan 1 ;508(1):97-101. Epub 2018 Nov 22. PMID: 30471854

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Atherosclerosis, Cardiovascular Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic, MicroRNA modulator

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View the Evidence: 150 Abstracts with Nobiletin Research

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Nobiletin appears to be a promising novel prophylactic seed drug or functional food for Alzheimer's disease.Dec 31, 2017

Nobiletin could alleviate iron overload damage in vascular endothelium.Jan 29, 2020

Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes.Mar 26, 2020

These data suggest that nobiletin might be a potential antithrombotic agent of dietary origin.Mar 14, 2017

Ameliorating effect of Citrus aurantium extracts and nobiletin on β‑amyloid (1‑42)‑induced memory impairment.Aug 08, 2019

Bidirectional interaction of nobiletin and gut microbiota in mice fed with a high-fat diet.Apr 25, 2021

Combinations of nobiletin with paclitaxel and carboplatin significantly suppressed the growth of subcutaneous A549 tumors xenografts in nude mice.Mar 31, 2014

Effects of the clock modulator nobiletin on circadian rhythms and pathophysiology in female mice of an Alzheimer's disease model.Jul 08, 2021

Endothelium-independent vasodilator effects of nobiletin in rat aorta.Apr 30, 2019

In vitro and In vivo effects of nobiletin on DRG neurite elongation and axon growth after sciatic nerve injury.Aug 25, 2021

Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in animals.Aug 31, 2018

Long-term dietary supplementation with low-dose nobiletin ameliorates hepatic steatosis, insulin resistance, and inflammation.Jul 31, 2017

Nobiletin alleviates cerebral ischemic-reperfusion injury via MAPK signaling pathway.Dec 31, 2018

Nobiletin alleviates high-fat diet-induced nonalcoholic fatty liver disease.Oct 19, 2020

Nobiletin alleviates ischemia/reperfusion injury in the kidney by activating PI3K/AKT pathway.Nov 30, 2020

Nobiletin alleviates non-alcoholic steatohepatitis.Dec 31, 2020

Nobiletin ameliorates cardiac impairment and alleviates cardiac remodeling after acute myocardial infarction.Dec 31, 2020

Nobiletin ameliorates myocardial ischemia and reperfusion injury.May 09, 2019

Nobiletin ameliorates streptozotocin-cadmium-induced diabetic nephropathy via NF-κB signalling pathway.Aug 03, 2021

Nobiletin ameliorates the cardiovascular dysfunction of diabetes by inhibiting oxidative stress, MMP-2 and MMP-9.Jul 12, 2016

Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis.Mar 31, 2017

Nobiletin and tangeretin may ameliorate scratching behavioral reactions by inhibiting the action of histamineOct 31, 2013

Nobiletin attenuates acetaminophen-induced hepatorenal toxicity.Nov 26, 2019

Nobiletin attenuates adverse cardiac remodeling after acute myocardial infarction in rats.Aug 18, 2017

Nobiletin attenuates cardiac dysfunction, oxidative stress, and inflammatory in streptozotocin: induced diabetic cardiomyopathy.May 31, 2016

Nobiletin attenuates pathological cardiac remodeling after myocardial infarction.Dec 31, 2020

Nobiletin can ameliorate ischemia-reperfusion injury after liver transplantation.Apr 30, 2017

Nobiletin can specifically improve memories of emotionally salient information associated with fear and novelty.Nov 08, 2016

Nobiletin clearly restored the alveolar bone mass in a mouse experimental model for periodontitis by inhibiting LPS-induced bone resorption.Dec 31, 2011

Nobiletin could be used as a potential therapeutic to counter the nonylphenol-prompted oxidative stress and apoptotic damages in testes.Aug 19, 2020

Nobiletin could be used as an intervention that enhances circadian rhythms to combat metabolic disease via the circadian gene network.Apr 11, 2016

Nobiletin decreases inflammatory symptoms and markers in murine colitis.Mar 09, 2018

Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge.Aug 27, 2019

Nobiletin has an anticell proliferative effect on DMBA-induced mammary cancer.Dec 31, 2019

Nobiletin has gastroprotective effects against ethanol-induced acute gastric lesions.Sep 25, 2017

Nobiletin has potential application in extension of lifespan.Jan 03, 2020

Nobiletin has shown that it has protective effects by reducing kidney damage caused by ischemia-reperfusion injury.Nov 07, 2019

Nobiletin improves propofol-induced neuroprotection in ischemic brain injury.Dec 31, 2016

Nobiletin may be a potential therapeutic agent for the treatment of osteoarthritis.Dec 31, 2018

Nobiletin may have potential use as a chemopreventive agent against nasopharyngeal cancer metastasis.Feb 28, 2015

Nobiletin may serve as a potential approach to alleviate neuroinflammation-related diseases.May 07, 2019

Nobiletin may serve as a potential therapeutic agent for the treatment of HCD-induced hypercholesterolemia and NAFLD.Jul 31, 2021

Nobiletin might have a great potential for treating glioblastoma.Apr 30, 2017

Nobiletin prevents against acute liver injury.Jun 13, 2020

Nobiletin prevents memory impairment and exhibits a protecting action against neurodgeneration in a alzheimer's disease model.Dec 31, 2014

Nobiletin protects against cardiac hypertrophy induced by pressure-overload.Jul 12, 2017

Nobiletin protects against myocardial injury and myocardial apoptosis following coronary microembolization.May 08, 2019

Nobiletin reduced the levels of soluble Aβ1-40 in the brain of 3XTg-AD mice and reduced ROS levels in the hippocampus of 3XTg-AD as well as wild-type mice.Jul 31, 2015

Nobiletin rescues motor and cognitive dysfunction in a MPTP-induced Parkinson model mice, in part by enhancing dopamine release.Feb 13, 2014

Nobiletin restored intestinal barrier function, which had been damaged after TNBS administration, through the inhibition of the Akt-NF-κB-MLCK pathway.Apr 30, 2015

Nobiletin restores reduced mitochondrial metabolism in hypothyroid rat hippocampus through acceleration of matrix substrate-level phosphorylation.Mar 16, 2014

Nobiletin reversed paclitaxel resistance in multi-drug resistance tumors.Nov 25, 2019

Nobiletin supplementation inhibited activation of apoptotic pathways and DNA damage.May 18, 2015

Nobiletin treatment ameliorated motor functional deficits in the ischemic rats compared with those deficits of the vehicle-treated group.Apr 21, 2014

Nobiletin-loaded composite penetration enhancer vesicles restore the normal miRNA expression and the chief defence antioxidant levels in skin cancer.Oct 11, 2021

Nobiletin-loaded micelles reduce ovariectomy-induced bone loss by suppressing osteoclastogenesis.Dec 31, 2018

Oral administration of nobiletin significantly inhibited colitis-associated colon carcinogenesis in mice.Sep 09, 2015

Protective effects of nobiletin on cisplatin induced neurotoxicity.Mar 07, 2021

Supplementation with nobiletin may protect against the neurodegeneration involved in PD. Mar 31, 2015

Tangerine peel possesses potent anti-neuroinflammatory capacity which is attributed to the collective effect of hesperidin, nobiletin, and tangeretin.Aug 31, 2014

The anti-neoplastic activity of nobiletin was due to its ability to inhibit angiogenesisMay 31, 2015

The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat fed- mice independent of AMPK.Jan 20, 2020

The observations of this study indicate protective effects of nobiletin against cadmium-induced neurotoxicity.Jan 15, 2018

The results suggest that nobiletin attenuates experimental autoimmune encephalomyelitis severity through modulation of Th17 cell differentiation. Aug 31, 2021

These findings provide support for the molecular mechanisms underlying the effects of nobiletin treatment on isoflurane-induced damage.Oct 31, 2016

These findings support the potential for nobiletin as a therapeutic agent for the treatment of acute liver injury.Nov 14, 2016

These results demonstrated that nobiletin inhibited the development of rheumatoid arthritis.Nov 20, 2017

These results suggest that nobiletin attenuates high fat diet-induced vascular and renal alterations.Sep 09, 2020

This study provides the first evidence that nobiletin exert protection on endometriosis.Jun 04, 2018

Nobiletin affects circadian rhythms and oncogenic characteristics in a cell-dependent manner.Dec 31, 2019

Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells.Jun 14, 2013

Nobiletin selectively inhibits oral cancer cell growth by promoting apoptosis and DNA damage in vitro.Jul 03, 2020

Nobiletin

View the Evidence:
150 Abstracts with Nobiletin Research