Oleanolic acid

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77 Diseases Researched for Oleanolic acid
NameACCKFocus
Prediabetes314Locked
Diabetes Mellitus: Type 2: Prevention110Locked
Hyperlipidemia110Locked
Multiple Sclerosis36Locked
Alzheimer's Disease45Locked
Gastric Cancer45Locked
Liver Cancer55Locked
Breast Cancer34Locked
Cancers: All34Locked
Cardiovascular Diseases34Locked
Colorectal Cancer24Locked
Ischemia24Locked
Osteoarthritis34Locked
Osteoporosis24Locked
Breast Cancer: Triple Negative 23Locked
Chemically-Induced Liver Damage23Locked
HIV Infections23Locked
Inflammation23Locked
Lung Cancer33Locked
Allergies12Locked
Atherosclerosis12Locked
Cerebral Ischemia12Locked
Chemotherapy-Induced Toxicity: Cisplatin12Locked
Chemotherapy-Induced Toxicity: Doxorubicin12Locked
Dementia12Locked
Diabetic Complications12Locked
Diarrhea12Locked
Fibrosis12Locked
Gastrointestinal Diseases12Locked
Glioblastoma12Locked
Hyperglycemia12Locked
Hypertension12Locked
Immune Dysregulation: TH1/TH2 imbalance12Locked
Inflammatory Bowel Diseases12Locked
Insulin Resistance12Locked
Kidney Damage12Locked
Liver Injury: Ischemia/reperfusion 12Locked
Lung Inflammation12Locked
Malignant Melanoma12Locked
Melanoma12Locked
Non-Small-Cell Lung Carcinoma12Locked
Nonalcoholic fatty liver disease (NAFLD)12Locked
Obesity12Locked
Osteosarcoma22Locked
Polychlorinated biphenyl toxicity 12Locked
Prostate Cancer12Locked
Salmonella Infections12Locked
Spinal Cord Injuries12Locked
Subarachnoid hemorrhage12Locked
Tuberculosis12Locked
Aging Skin11Locked
Air Pollution Linked Toxicity11Locked
Bacillus Cereus infection11Locked
Bladder Cancer11Locked
Brain Inflammation 11Locked
Cancers: Drug Resistant11Locked
Cervical Cancer11Locked
Colon Cancer11Locked
Coronavirus Infection11Locked
Enterococcus Infections11Locked
Enterovirus 7111Locked
Glioma11Locked
Hepatitis B 11Locked
Hepatitis C11Locked
Herpes Simplex Virus Type 111Locked
Herpes Simplex Virus Type 211Locked
Hypoglycemia11Locked
Klesiella Pneumonia Infection11Locked
Metabolic Syndrome X11Locked
Mycobacterium tuberculosis11Locked
Neurodegenerative Diseases11Locked
Oxidative Stress11Locked
Parkinson's Disease11Locked
Staphylococcus aureus infection11Locked
Staphylococcus aureus: Methicillin-resistant (MRSA)11Locked
Streptococcus Infections11Locked
Thyroid Cancer11Locked
54 Pharmacological Actions Researched for Oleanolic acid
NameACCKFocus
Anti-Inflammatory Agents1727Locked
Antioxidants1117Locked
Apoptotic1214Locked
Hypolipidemic313Locked
Antiproliferative 1012Locked
MicroRNA modulator211Locked
Neuroprotective Agents711Locked
Anti-Apoptotic510Locked
Cardioprotective57Locked
Hepatoprotective47Locked
Interleukin-6 Downregulation47Locked
Cell cycle arrest56Locked
NF-kappaB Inhibitor46Locked
Anti-metastatic55Locked
Autophagy Inhibitors35Locked
Interleukin-1 beta downregulation35Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor35Locked
Antihypertensive Agents34Locked
Chemoprotective Agents24Locked
Chemosensitizer34Locked
Gastrointestinal Agents24Locked
Osteoprotective 24Locked
Anti-Bacterial Agents23Locked
Anti-HIV Agents23Locked
Antiviral Agents33Locked
Autophagy Up-regulation23Locked
Chemotherapeutic33Locked
Hypoglycemic Agents23Locked
Angiogenesis Inhibitors12Locked
Anti-Allergic Agents12Locked
Anti-Angiogenic12Locked
Anti-Fibrotic12Locked
Anti-Tumor12Locked
Antidiarrheals12Locked
Antineoplastic Agents12Locked
Antinoceceptive 12Locked
Antioxidant12Locked
Chemopreventive22Locked
Gastroprotective12Locked
HIV Protease Inhibitors12Locked
Immunomodulatory12Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor12Locked
P21 Activation12Locked
Radiosensitizer12Locked
Renoprotective12Locked
STAT3 Inhibitor12Locked
Tumor Suppressor Protein p53 Upregulation12Locked
Antimicrobial11Locked
Bcl-2 protein down-regulation11Locked
Cytotoxic11Locked
Genoprotective11Locked
Nitric Oxide Inhibitor11Locked
Reverse Transcriptase Inhibitors11Locked
Wnt/β-catenin signaling pathway modulation11Locked

View the Evidence:
80 Abstracts with Oleanolic acid Research

[+]

The intake of oleanolic acid-enriched olive oil reduces the risk of developing diabetes in prediabetic patients.Jul 30, 2019

Pubmed Data : Diabetes Obes Metab. 2019 Jul 31. Epub 2019 Jul 31. PMID: 31364228
Article Published Date : Jul 30, 2019
Study Type : Human Study
Additional Links
Substances : Oleanolic acid, Olive Oil
Diseases : Diabetes Mellitus: Type 2: Prevention, Prediabetes
Additional Keywords : Risk Reduction
[+]

This data showed a clinical evidence that oleanolic acid could improve hyperlipidemia.Apr 30, 2018

Pubmed Data : Chin J Nat Med. 2018 May ;16(5):339-346. PMID: 29860994
Article Published Date : Apr 30, 2018
Study Type : Human Study
Additional Links
Substances : Oleanolic acid
Diseases : Hyperlipidemia
Pharmacological Actions : Hypolipidemic, MicroRNA modulator
[+]

Antihypertensive activity of oleanolic acid is mediated via downregulation of secretory phospholipase A2 and fatty acid synthase.Nov 30, 2020

Pubmed Data : Int J Mol Med. 2020 Dec ;46(6):2019-2034. Epub 2020 Sep 30. PMID: 33125128
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
[+]

Croton tiglium, Cynomorium songaricum, Xanthoceras sorbifolia, and oleanolic acid derivates exhibit anti-HIV activity. Aug 01, 2004

Pubmed Data : Yakugaku Zasshi. 2004 Aug;124(8):519-29. PMID: 15297721
Article Published Date : Aug 01, 2004
Study Type : Animal Study
Additional Links
Substances : Croton Tiglium , Cynomorium songaricum, Oleanolic acid, Xanthoceras sorbifolia
Diseases : HIV Infections
Pharmacological Actions : Anti-HIV Agents, HIV Protease Inhibitors
Additional Keywords : Plant Extracts
[+]

Neuroprotective effects of oleanolic acid against cerebral ischemia-reperfusion injury in mice.Jun 17, 2021

Pubmed Data : Exp Neurol. 2021 Jun 18:113785. Epub 2021 Jun 18. PMID: 34153323
Article Published Date : Jun 17, 2021
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Cerebral Ischemia
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Oleanolic acid acetate alleviates symptoms of experimental autoimmune encephalomyelitis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:556391. Epub 2020 Sep 3. PMID: 33013394
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Multiple Sclerosis
Pharmacological Actions : Immunomodulatory
[+]

Oleanolic acid acetate may mitigate the inflammatory response and development of pulmonary fibrosis in the lungs.Mar 01, 2018

Pubmed Data : Respir Physiol Neurobiol. 2018 Mar 2 ;252-253:1-9. Epub 2018 Mar 2. PMID: 29505886
Article Published Date : Mar 01, 2018
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Fibrosis, Lung Inflammation
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Oleanolic acid ameliorates intestinal alterations associated with EAE.Nov 26, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neuroinflammation. 2020 Nov 27 ;17(1):363. Epub 2020 Nov 27. PMID: 33246492
Article Published Date : Nov 26, 2020
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Multiple Sclerosis
Pharmacological Actions : Antioxidant, Gastrointestinal Agents
[+]

Oleanolic acid ameliorates risk factors of cardiovascular diseases in a diet-Induced pre-diabetic rat model.Jan 17, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Jan 18 ;24(2). Epub 2019 Jan 18. PMID: 30669379
Article Published Date : Jan 17, 2019
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Cardiovascular Diseases, Prediabetes
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Oleanolic acid ameliorates the risk of developing pre-diabetes-related NAFLD.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Diabetes Metab Syndr Obes. 2019 ;12:1953-1962. Epub 2019 Oct 1. PMID: 31632109
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Nonalcoholic fatty liver disease (NAFLD), Prediabetes
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Hypolipidemic
[+]

Oleanolic acid and ursolic acid improve bone properties and calcium nalance and modulate vitamin D metabolism in aged female rats.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:1435. Epub 2018 Dec 4. PMID: 30564129
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid, Ursolic Acid
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
[+]

Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity.Jul 11, 2019

Pubmed Data : Food Chem Toxicol. 2019 Jul 12 ;132:110676. Epub 2019 Jul 12. PMID: 31306688
Article Published Date : Jul 11, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Oleanolic acid attenuates PCBs-induced adiposity and insulin resistance.Jun 03, 2018

Pubmed Data : Free Radic Biol Med. 2018 Jun 4. Epub 2018 Jun 4. PMID: 29879443
Article Published Date : Jun 03, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Insulin Resistance, Polychlorinated biphenyl toxicity
Pharmacological Actions : Antioxidants
Problem Substances : Polychlorinated biphenyls (PCBs)
[+]

Oleanolic acid combined with olaparib enhances radiosensitization in triple negative breast cancer and hypoxia.Apr 24, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2022 Apr 25 ;150:113007. Epub 2022 Apr 25. PMID: 35483190
Article Published Date : Apr 24, 2022
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Radiosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Oleanolic acid could ameliorate Aβ-induced spatial learning and memory loss.May 23, 2018

Pubmed Data : CNS Neurol Disord Drug Targets. 2018 May 24. Epub 2018 May 24. PMID: 29793416
Article Published Date : May 23, 2018
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Oleanolic acid delayed the formation of MGC-803 tumours in an autophagy-dependent manner.Jun 30, 2016

Pubmed Data : Cell Biol Int. 2016 Jul ;40(7):770-8. Epub 2016 May 19. PMID: 27079177
Article Published Date : Jun 30, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Gastric Cancer
Pharmacological Actions : Autophagy Up-regulation
[+]

Oleanolic acid enhances tight junctions and ameliorates inflammation in Salmonella typhimurium-induced diarrhea.Jan 28, 2020

Pubmed Data : Food Funct. 2020 Jan 29 ;11(1):1122-1132. PMID: 31825448
Article Published Date : Jan 28, 2020
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Diarrhea, Salmonella Infections
Pharmacological Actions : Anti-Inflammatory Agents, Antidiarrheals, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Oleanolic acid exerts bone protective effects in ovariectomized mice by inhibiting osteoclastogenesis.Apr 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Sci. 2018 May ;137(1):76-85. Epub 2018 Apr 6. PMID: 29703642
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Osteoporosis
Additional Keywords : Ovariectomy-Induced Changes
[+]

Oleanolic acid exerts inhibitory effects on the late stage of osteoclastogenesis and prevents bone loss in osteoprotegerin knockout mice.Jul 17, 2019

Pubmed Data : J Cell Biochem. 2019 Jul 18. Epub 2019 Jul 18. PMID: 31318102
Article Published Date : Jul 17, 2019
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Pharmacological Actions : Matrix metalloproteinase-9 (MMP-9) inhibitor, Osteoprotective
[+]

Oleanolic acid exerts neuroprotective effects in subarachnoid hemorrhage rats through SIRT1-mediated HMGB1 deacetylation.Feb 14, 2021

Pubmed Data : Eur J Pharmacol. 2021 Feb 15 ;893:173811. Epub 2020 Dec 24. PMID: 33345851
Article Published Date : Feb 14, 2021
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Subarachnoid hemorrhage
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Oleanolic acid exhibits hepatoprotective effects via activation of PPARα and inhibition of apoptosis and autophagy.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PPAR Res. 2018 ;2018:3180396. Epub 2018 Apr 2. PMID: 29805439
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Apoptotic, Autophagy Inhibitors, Hepatoprotective
[+]

Oleanolic acid improves diabetes-induced haematological changes caused by hyperglycaemia and attenuates the progression of cardiovascular complications.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Diabetes Res. 2019 ;2019:6753541. Epub 2019 Nov 19. PMID: 31828165
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Diabetic Complications, Hyperglycemia
Pharmacological Actions : Antioxidants, Hypoglycemic Agents
[+]

Oleanolic acid improves diet-induced obesity by modulating fat preference and inflammation in mice.Jun 28, 2018

Pubmed Data : Biochimie. 2018 Jun 29. Epub 2018 Jun 29. PMID: 29966735
Article Published Date : Jun 28, 2018
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
Additional Keywords : Gene Expression Regulation
[+]

Oleanolic acid improves the symptom of renal ischemia reperfusion injury.Dec 07, 2020

Pubmed Data : Urol Int. 2020 Dec 8:1-6. Epub 2020 Dec 8. PMID: 33291121
Article Published Date : Dec 07, 2020
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Ischemia, Kidney Damage
Pharmacological Actions : Renoprotective
[+]

Oleanolic acid inhibits colorectal cancer angiogenesis in vivo and in vitro.May 31, 2016

Pubmed Data : Mol Med Rep. 2016 Jun ;13(6):5276-82. Epub 2016 Apr 22. PMID: 27108756
Article Published Date : May 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Colorectal Cancer
Pharmacological Actions : Angiogenesis Inhibitors, STAT3 Inhibitor
[+]

Oleanolic acid inhibits mouse spinal cord injury through suppressing inflammation and apoptosis Feb 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Mar ;123:109752. Epub 2020 Jan 8. PMID: 31924596
Article Published Date : Feb 29, 2020
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Oleanolic acid inhibits the growth of DU145, MCF-7, and U87 cancer cells.May 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2018 May 29 ;9(41):26370-26386. Epub 2018 May 29. PMID: 29899865
Article Published Date : May 28, 2018
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Breast Cancer, Glioblastoma, Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, P21 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

Oleanolic acid may have beneficial effects on some processes associated with renal derangement of type 1diabetic rats.Jan 01, 2009

Pubmed Data : Ren Fail. 2009;31(6):481-91. PMID: 19839826
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Additional Keywords : Plant Extracts
[+]

Oleanolic acid protects against mast cell-mediated allergic responses by suppressing Akt/NF-κB and STAT1 activation.Dec 31, 2020

Pubmed Data : Phytomedicine. 2021 Jan ;80:153340. Epub 2020 Oct 15. PMID: 33130471
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Allergies, Inflammation
Pharmacological Actions : Anti-Allergic Agents, Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Oleanolic acid protects against pathogenesis of atherosclerosis.Dec 31, 2017

Pubmed Data : Biomed Pharmacother. 2018 Jan ;97:1694-1700. Epub 2017 Dec 8. PMID: 29793333
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Atherosclerosis
[+]

Oleanolic acid reduces the severity and development of autoimmune encephalomyelitis and improves the TH1/TH2 polarization in an experimental model of multiple sclerosis. Jan 01, 2009

Pubmed Data : Physiol Res. 2009;58(4):511-9. Epub 2008 Jul 25. PMID: 19679109
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Immune Dysregulation: TH1/TH2 imbalance, Multiple Sclerosis
[+]

Peripheral anti-nociceptive and anti-inflammatory effect of oleanolic acid in a rat model of osteoarthritis.Nov 10, 2020

Pubmed Data : Antiinflamm Antiallergy Agents Med Chem. 2020 Nov 11. Epub 2020 Nov 11. PMID: 33183210
Article Published Date : Nov 10, 2020
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive
[+]

Research advances in protective effects of ursolic acid and oleanolic acid against gastrointestinal diseases.Feb 19, 2021

Pubmed Data : Am J Chin Med. 2021 Feb 20:1-23. Epub 2021 Feb 20. PMID: 33622215
Article Published Date : Feb 19, 2021
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid, Ursolic Acid
Diseases : Colorectal Cancer, Gastrointestinal Diseases, Inflammatory Bowel Diseases
Pharmacological Actions : Gastrointestinal Agents, Gastroprotective
[+]

Targeted delivery of ursolic acid and oleanolic acid to lungs in the form of an inhaler for the management of tuberculosis.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2022 ;17(12):e0278103. Epub 2022 Dec 29. PMID: 36580459
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid, Ursolic Acid
Diseases : Tuberculosis
Pharmacological Actions : Anti-Bacterial Agents
[+]

The addition of solubilized mistletoe triterpenoids to conventional mistletoe extracts significantly improves the efficacy of mistletoe treatment.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(4):e62168. Epub 2013 Apr 17. PMID: 23614029
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Mistletoe, Oleanolic acid
Diseases : Cancers: All, Malignant Melanoma, Melanoma
Pharmacological Actions : Anti-Angiogenic, Anti-Tumor, Antineoplastic Agents, Apoptotic
Additional Keywords : Natural Substance Synergy, Phytotherapy, Plant Extracts, Significant Treatment Outcome , Solubilized Triterpenoids
[+]

The present study backs the cardioprotective effect of oleanolic acid on doxorubicin -induced cardiac toxicity.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2016 ;8(1):60-9. Epub 2016 Jan 15. PMID: 27069540
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents
[+]

The present study reported a novel therapeutic strategy for the treatment of renal ischemia/reperfusion injury.May 31, 2016

Pubmed Data : Mol Med Rep. 2016 Jun ;13(6):4697-704. Epub 2016 Apr 14. PMID: 27082705
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Ischemia
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants
[+]

These findings highlighted the protective effects of oleanolic acid against hepatic ischemia reperfusion injury.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2019 ;2019:3240713. Epub 2019 Jun 18. PMID: 31316298
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Anti-Apoptotic, Autophagy Inhibitors, Hepatoprotective
[+]

Ursolic acid and its isomer oleanolic acid are responsible for the anti-dementia effects of Ocimum sanctum.Feb 25, 2022

Pubmed Data : J Nat Med. 2022 Feb 26. Epub 2022 Feb 26. PMID: 35218459
Article Published Date : Feb 25, 2022
Study Type : Animal Study
Additional Links
Substances : Holy Basil, Oleanolic acid, Ursolic Acid
Diseases : Dementia
Pharmacological Actions : Neuroprotective Agents
[+]

Ursolic Acid and oleanolic acid reduced the proliferation of A549 cells in nude mice.Dec 31, 2015

Pubmed Data : Genet Mol Res. 2016 ;15(2). Epub 2016 May 13. PMID: 27323036
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Loquat, Oleanolic acid, Ursolic Acid
Diseases : Non-Small-Cell Lung Carcinoma
Pharmacological Actions : Antiproliferative
Additional Keywords : Plant Extracts, Traditional Chinese Medicine
[+]

Advances on the anti-inflammatory activity of oleanolic acid and derivatives. Jan 25, 2021

Pubmed Data : Mini Rev Med Chem. 2021 Jan 26. Epub 2021 Jan 26. PMID: 33573541
Article Published Date : Jan 25, 2021
Study Type : Review
Additional Links
Substances : Oleanolic acid
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Candidate anti-COVID-19 medicinal plants from Ethiopia.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:6622410. Epub 2021 Jun 4. PMID: 34221083
Article Published Date : Dec 31, 2020
Study Type : Review
Additional Links
Substances : Allicin, Almond, Apigenin, Artemisinin, Curcumin, EGCG (Epigallocatechin gallate), Gingerol , Hesperidin, Kaempferol, Nobiletin , Oleanolic acid, Piperine, Resveratrol, Rosmarinic acid, Tangeretin , Ursolic Acid
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Co-delivery of cisplatin and oleanolic acid by silica nanoparticles-enhanced apoptosis and reverse multidrug resistance in lung cancer.Feb 07, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Kaohsiung J Med Sci. 2021 Feb 8. Epub 2021 Feb 8. PMID: 33559348
Article Published Date : Feb 07, 2021
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Lung Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Co-delivery of doxorubicin and oleanolic acid by triple-sensitive nanocomposite based on chitosan for effective promoting tumor apoptosis.Oct 31, 2020

Pubmed Data : Carbohydr Polym. 2020 Nov 1 ;247:116672. Epub 2020 Jun 23. PMID: 32829800
Article Published Date : Oct 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Cancers: All
Pharmacological Actions : Apoptotic
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin, Tumor Microenvironment
[+]

Exploring the underlying mechanism of oleanolic acid treating glioma by transcriptome and molecular docking.Sep 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2022 Oct ;154:113586. Epub 2022 Aug 22. PMID: 36007277
Article Published Date : Sep 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Glioma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Hypotensive effects of the triterpene oleanolic acid for cardiovascular prevention.Dec 29, 2020

Pubmed Data : Curr Mol Pharmacol. 2020 Dec 30. Epub 2020 Dec 30. PMID: 33390142
Article Published Date : Dec 29, 2020
Study Type : Review
Additional Links
Substances : Oleanolic acid
Diseases : Cardiovascular Diseases
Pharmacological Actions : Antihypertensive Agents, Cardioprotective
[+]

Inhibition of NF-κB is required for oleanolic acid to downregulate PD-L1 by promoting DNA demethylation in gastric cancer cells.Dec 31, 2020

Pubmed Data : J Biochem Mol Toxicol. 2021 Jan ;35(1):e22621. Epub 2020 Sep 7. PMID: 32894642
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Gastric Cancer
Pharmacological Actions : Chemotherapeutic
[+]

Inhibitory role of oleanolic acid and esculetin in HeLa cells involve multiple signaling pathways.Feb 28, 2021

Pubmed Data : Gene. 2021 Mar 1 ;771:145370. Epub 2020 Dec 24. PMID: 33346097
Article Published Date : Feb 28, 2021
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest
[+]

New applications of oleanolic acid and its derivatives as cardioprotective agents.Dec 31, 2018

Pubmed Data : Curr Pharm Des. 2019 ;25(35):3740-3750. PMID: 31692428
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Oleanolic acid
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective
[+]

Oleanolic acid can be a molecule that may be utilised in the treatment of liver cancer in the future.Aug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J BUON. 2019 Sep-Oct;24(5):1964-1969. PMID: 31786862
Article Published Date : Aug 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Cell cycle arrest
[+]

Oleanolic acid could act as a chemopreventive agent in human breast cancer and could inhibit the proliferation of highly invasive breast cancer cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2015 ;20(8):13670-88. Epub 2015 Jul 28. PMID: 26225949
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Chemopreventive, Genoprotective
[+]

Oleanolic acid enhances neural stem cell migration, proliferation, and differentiation in vitro by inhibiting GSK3β activity.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Discov. 2018 ;4:48. Epub 2018 Oct 15. PMID: 30345079
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Neural Stem Cells
[+]

Oleanolic acid exerts a neuroprotective effect against microglial cell activation by modulating cytokine release and antioxidant defense systems.Oct 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2019 Nov 1 ;9(11). Epub 2019 Nov 1. PMID: 31683841
Article Published Date : Oct 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Oleanolic acid exerts an anticancer effect via autophagic cell death in hepatocellular carcinoma.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Physiol Pharmacol. 2016 May ;20(3):237-43. Epub 2016 Apr 26. PMID: 27162477
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
[+]

Oleanolic acid exhibited cytotoxicity which was similar with that of the positive control 5-fluorouracil.Jun 07, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Jun 8 ;23(6). Epub 2018 Jun 8. PMID: 29890672
Article Published Date : Jun 07, 2018
Study Type : In Vitro Study
Additional Links
Substances : Mango , Oleanolic acid
Diseases : Lung Cancer
Pharmacological Actions : Cytotoxic
[+]

Oleanolic acid has anti-HIV activity on infected human mononuclear cells, in vitor. Feb 01, 2002

Pubmed Data : Planta Med. 2002 Feb;68(2):111-4. PMID: 11859458
Article Published Date : Feb 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : HIV Infections
Pharmacological Actions : Anti-HIV Agents, Reverse Transcriptase Inhibitors
[+]

Oleanolic acid induces osteosarcoma cell apoptosis by inhibition of Notch signaling.Mar 21, 2018

Pubmed Data : Mol Carcinog. 2018 Mar 22. Epub 2018 Mar 22. PMID: 29566282
Article Published Date : Mar 21, 2018
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Osteosarcoma
Pharmacological Actions : Apoptotic
[+]

Oleanolic acid inhibited synovial inflammation by suppressing the NF-κB signal pathway.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:7517219. Epub 2020 Sep 28. PMID: 33062145
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Oleanolic acid inhibits cell proliferation migration and invasion and induces SW579 thyroid cancer cell line apoptosis.Mar 13, 2019

Pubmed Data : Anticancer Drugs. 2019 Mar 14. Epub 2019 Mar 14. PMID: 30882397
Article Published Date : Mar 13, 2019
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Thyroid Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

Oleanolic acid inhibits epithelial-mesenchymal transition of hepatocellular carcinoma.Dec 31, 2018

Pubmed Data : Mol Cancer Ther. 2019 01 ;18(1):62-74. Epub 2018 Oct 8. PMID: 30297361
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Oleanolic acid inhibits high salt-induced exaggeration of warburg-like metabolism in breast cancer cells.May 27, 2016

Pubmed Data : Cell Biochem Biophys. 2016 May 28. Epub 2016 May 28. PMID: 27236294
Article Published Date : May 27, 2016
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Warburg Effect
[+]

Oleanolic acid inhibits osteosarcoma cell proliferation and invasion by suppressing the SOX9/Wnt1 signaling pathway.Apr 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2021 May ;21(5):443. Epub 2021 Feb 28. PMID: 33747179
Article Published Date : Apr 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Osteosarcoma
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

Oleanolic acid may be a therapeutic agent in the treatment of human hepatocellular carcinoma.Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2015 Oct ;12(4):5012-8. Epub 2015 Jul 2. PMID: 26151733
Article Published Date : Sep 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest
Additional Keywords : Dose Response
[+]

Oleanolic acid may protect neurons from injury caused by neighbouring astrocyte activation in Alzheimer's disease.May 06, 2018

Pubmed Data : Mol Immunol. 2018 May 7 ;99:95-103. Epub 2018 May 7. PMID: 29747052
Article Published Date : May 06, 2018
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Alzheimer's Disease, Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Oleanolic acid mitigates interleukin-1β-induced chondrocyte dysfunction.Feb 05, 2020

Pubmed Data : J Gene Med. 2020 Feb 6:e3169. Epub 2020 Feb 6. PMID: 32028542
Article Published Date : Feb 05, 2020
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator
[+]

Oleanolic acid produces its anti-tumor effect via induction of cell cycle arrest and apoptosis.Nov 30, 2015

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2015 Dec ;40(24):4897-902. PMID: 27245040
Article Published Date : Nov 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
[+]

Oleanolic acid protects the skin from particulate matter-induced aging.Sep 20, 2020

Pubmed Data : Biomol Ther (Seoul). 2020 Sep 21. Epub 2020 Sep 21. PMID: 32952129
Article Published Date : Sep 20, 2020
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Aging Skin, Air Pollution Linked Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Oleanolic acid reduces aerobic glycolysis-associated proliferation by inhibiting yes-associated protein in gastric cancer cells.Jun 30, 2019

Pubmed Data : Gene. 2019 Jul 1 ;712:143956. Epub 2019 Jul 1. PMID: 31271843
Article Published Date : Jun 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Cancer Glycolysis
[+]

Oleanolic acid reprograms the liver to protect against hepatotoxicants, but is hepatotoxic at high doses.Aug 05, 2018

Pubmed Data : Liver Int. 2018 Aug 6. Epub 2018 Aug 6. PMID: 30079536
Article Published Date : Aug 05, 2018
Study Type : Review
Additional Links
Substances : Oleanolic acid
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Dose Response
[+]

Oleanolic acid suppresses the proliferation of human bladder cancer cells. Dec 31, 2014

Pubmed Data : Int J Clin Exp Pathol. 2015 ;8(11):13864-70. Epub 2015 Nov 1. PMID: 26823699
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Bladder Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemopreventive
[+]

Phyllanthus amarus exerts various anticancer and anti-inflammatory activities.Jan 31, 2020

Pubmed Data : Inflammopharmacology. 2020 Feb ;28(1):1-18. Epub 2019 Dec 2. PMID: 31792765
Article Published Date : Jan 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid, Flavonoids, Oleanolic acid, Phyllanthus amarus , Ursolic Acid
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Wnt/β-catenin signaling pathway modulation
[+]

Potential protective effect of oleanolic acid on the components of metabolic syndrome.Aug 22, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Med. 2019 Aug 23 ;8(9). Epub 2019 Aug 23. PMID: 31450844
Article Published Date : Aug 22, 2019
Study Type : Review
Additional Links
Substances : Oleanolic acid
Diseases : Metabolic Syndrome X
Pharmacological Actions : Antihypertensive Agents, Antioxidants, Hypoglycemic Agents, Hypolipidemic
[+]

Synergism of cisplatin-oleanolic acid co-loaded hybrid nanoparticles on gastric carcinoma cells.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Deliv. 2020 Dec ;27(1):191-199. PMID: 31924110
Article Published Date : Nov 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Cancers: Drug Resistant, Gastric Cancer
Pharmacological Actions : Apoptotic, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

The present review investigates the potential use of these triterpenes against human pathogens, including their mechanisms of action.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:620472. Epub 2015 Feb 22. PMID: 25793002
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Oleanolic acid, Ursolic Acid
Diseases : Bacillus Cereus infection, Enterococcus Infections, Hepatitis B , Hepatitis C, Herpes Simplex Virus Type 1, Herpes Simplex Virus Type 2, Klesiella Pneumonia Infection, Mycobacterium Tuberculosis, Staphylococcus aureus: Methicillin-resistant (MRSA), Staphylococcus aureus infection, Streptococcus Infections
Pharmacological Actions : Anti-Bacterial Agents, Antimicrobial, Antiviral Agents
[+]

The results suggest these compounds show potential for further optimization as antiviral candidates for treatment of EV71 infections.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Chem Pharm Bull (Tokyo). 2014 ;62(8):764-71. PMID: 25087628
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid, Oleanolic acid, Ursolic Acid
Diseases : Enterovirus 71
Pharmacological Actions : Antiviral Agents
[+]

Treatment with oleanolic acid had a protective effect on high glucose-induced injury in cardiomyocytes.Aug 26, 2018

Pubmed Data : Am J Chin Med. 2018 Aug 27:1-15. Epub 2018 Aug 27. PMID: 30149760
Article Published Date : Aug 26, 2018
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid
Diseases : Hypoglycemia
Pharmacological Actions : Cardioprotective
[+]

Tuscan varieties of sweet cherry are rich sources of ursolic and oleanolic acid.Apr 21, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Apr 22 ;24(8). Epub 2019 Apr 22. PMID: 31013661
Article Published Date : Apr 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid, Sweet Cherry, Ursolic Acid
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Ursolic and oleanolic acids in combination therapy inhibit migration of colon cancer cells.Sep 29, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Chem Biol Interact. 2022 Sep 30:110202. Epub 2022 Sep 30. PMID: 36191607
Article Published Date : Sep 29, 2022
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid, Ursolic Acid
Diseases : Colon Cancer
Pharmacological Actions : Anti-metastatic
[+]

Ursolic and oleanolic acids induce mitophagy in A549 human lung cancer cells.Sep 22, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Sep 23 ;24(19). Epub 2019 Sep 23. PMID: 31547522
Article Published Date : Sep 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Oleanolic acid, Ursolic Acid
Diseases : Lung Cancer
Pharmacological Actions : Autophagy Inhibitors, Chemotherapeutic
[+]

Ursolic and oleanolic acids: plant metabolites with neuroprotective potential.Apr 26, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2021 Apr 27 ;22(9). Epub 2021 Apr 27. PMID: 33925641
Article Published Date : Apr 26, 2021
Study Type : Review
Additional Links
Substances : Oleanolic acid, Ursolic Acid
Diseases : Alzheimer's Disease, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents

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