Olive

Name	AC	CK
Oxidative Stress	32	90
Hypertension	11	71
Inflammation	27	68
Cardiovascular Diseases	16	58
Breast Cancer	20	43
Diabetes Mellitus: Type 2	15	33
Obesity	11	33
Upper Respiratory Infections	1	30
Insulin Resistance	6	28
Myocardial Infarction	5	27
Nonalcoholic fatty liver disease (NAFLD)	6	27
Lipopolysaccharide-Induced Toxicity	10	25
Arteriosclerosis	7	21
High Cholesterol	3	21
Breast Cancer: Prevention	2	20
Cancers: All	16	20
Ear Infection	2	20
Gastroesophageal Reflux	2	20
Cholesterol: Oxidation	7	19
Colon Cancer	10	17
DNA damage	7	16
High Fat Diet	8	16
Alzheimer's Disease	9	15
Atherosclerosis	5	15
Chemically-Induced Liver Damage	6	14
Hypercholesterolemia	3	14
HIV Infections	6	13
Hyperglycemia	3	13
Metabolic Syndrome X	4	13
Multiple Sclerosis	3	13
Clotting	2	12
Lipid Peroxidation	2	12
Parkinson's Disease	9	12
Ovarian Cancer	2	11
Anal Fissure	1	10
Angina Pectoris	1	10
Blepharitis	1	10
Blood Coagulation Disorders	1	10
Breast Milk: Inadequate/Poor Quality	1	10
C-Reactive Protein	1	10
Candidiasis: Vulvovaginal	1	10
Chemotherapy-Induced Toxicity: Cisplatin	5	10
Colitis	6	10
Constipation	1	10
Coronary Artery Disease	1	10
Cystitis	1	10
Dermatitis	1	10
Diaper Rash	1	10
Dyslipidemias	1	10
Infant Care	1	10
Meibomian gland dysfunction	1	10
Otitis media	1	10
Pityriasis Versicolor	1	10
Prediabetes	1	10
Prenatal Nutrition: Health of the Offspring	1	10
Prenatal Nutrition: Prevention of Problems	1	10
Psoriasis	1	10
Statin-Induced Pathologies	1	10
Tinea	1	10
Ulcerative Colitis	1	10
Urinary Tract Infections	1	10
Weight Problems	1	10
Wheezing: Infants	1	10
Neurodegenerative Diseases	9	9
Ultraviolet Radiation Induced Damage	4	9
Sepsis	4	8
Skin Diseases: Photo-Aging	3	8
Cognitive Decline/Dysfunction	4	7
Kidney Damage	4	7
Melanoma	5	7
Bisphenol-A Toxicity	1	6
Brain Inflammation	4	6
Brain: Oxidative Stress	4	6
Chemotherapy-Induced Toxicity	3	6
Chemotherapy-Induced Toxicity: Doxorubicin	3	6
Diabetes Mellitus: Type 1	2	6
Drug-Induced Toxicity: Indomethacin	3	6
Fatty Liver	2	6
Liver Fibrosis	3	6
Liver Steatosis	3	6
Mycobacterium Infections	2	6
Myocardial Ischemia	3	6
Prostate Cancer	4	6
Rheumatoid Arthritis	2	6
Skin Cancer	2	6
Asthma	2	5
Endothelial Dysfunction	3	5
Fibromyalgia	1	5
Hydrogen Peroxide Induced Toxicity	4	5
Hyperlipidemia	3	5
Inflammatory Bowel Diseases	3	5
Leishmaniasis	2	5
Liver Damage	3	5
Osteoarthritis	4	5
Osteoporosis	3	5
Arsenic Poisoning	2	4
Bisphenol Toxicity	1	4
Breast Cancer: Triple Negative	3	4
Cardiotoxicity: Chemotherapy-Induced	2	4
Chemotherapy and Radiation Toxicity	2	4
Diabetic Complications	2	4
Glioblastoma	4	4
Gout	1	4
Hyperuricemia	1	4
Insomnia	1	4
Ischemia	2	4
Kidney Damage: Chemically-Induced	2	4
Lead Poisoning	2	4
Liver Cancer	4	4
Opiate Tolerance	1	4
Post-Traumatic Stress Disorders (PTSD)	2	4
Pseudomonas aeruginosa	3	4
Staphylococcus aureus infection	4	4
Cadmium Poisoning	2	3
Colorectal Cancer	3	3
Mitochondrial Dysfunction	2	3
Neuropathic Pain	2	3
Pain	2	3
Pancreatic Cancer	2	3
Acquired Immunodeficiency Syndrome	2	2
Aging	1	2
Air Pollution Linked Toxicity	1	2
Alcohol Toxicity	1	2
Athletic Performance	1	2
Atopic Dermatitis	1	2
Autoimmune Diseases	1	2
Brain Ischemia	1	2
Cancer Metastasis	1	2
Cerebral Ischemia	1	2
Cerebral Stroke	1	2
Cervical Cancer	2	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Cholesterol: LDL/HDL ratio	1	2
Colorectal Cancer: Prevention	1	2
Depression	1	2
Diabetes: Oxidative Stress	1	2
Diabetic Retinopathy	1	2
Dysbiosis	1	2
Erythema	1	2
Esophageal Cancer	1	2
Fibrinogen: Elevated	1	2
Gastric Ulcer	1	2
Gastritis	1	2
Gastrointestinal Inflammation	1	2
Glioma	2	2
Gram-Positive Bacterial Infections	1	2
Heart Failure	1	2
Hyperalgesia	1	2
Infants: Low Birth Weight	1	2
Influenza	2	2
Intestinal Ischemia	1	2
Intracerebral Hemorrhage	1	2
Liver Cirrhosis	1	2
Liver Damage: Drug-Induced	1	2
Low Testosterone	1	2
Lung Cancer	2	2
Lung Injury: Acute	1	2
Malaria	1	2
Malignant Melanoma	1	2
Mastitis	1	2
Mesothelioma	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Mycotoxin Toxicity	1	2
Myocarditis: Autoimmune	1	2
Osteoporosis: Age-Related	1	2
Osteosarcoma	1	2
Pancreatitis	1	2
Periodontitis	1	2
Pesticide Toxicity: Permethrin	1	2
Prehypertension	1	2
Promyelocytic leukemia	2	2
Radiation Induced Illness	1	2
Seizures	1	2
Stroke: Ischemic	1	2
Sunburn	1	2
Testicular Diseases	1	2
Thrombosis	1	2
Triglycerides: Elevated	1	2
Tumors	1	2
Wound Healing	2	2
Advanced Glycation End products (AGE)	1	1
Amyloidosis	1	1
Bladder Cancer	1	1
Blue Light Toxicity	1	1
Breast Cancer: Bone Metastasis	1	1
Campylobacter Infections	1	1
Cancers: Drug Resistant	1	1
Candida Infection	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	1
Chronic Kidney Disease (CKD)	1	1
Chronic Myeloid Leukemia	1	1
Chronic Obstructive Pulmonary Disease	1	1
Common Cold	1	1
Coronavirus Infection	1	1
Dementia	1	1
Dementia: Alzheimer Type	1	1
Drug-Induced Toxicity: L-Thyroxine	1	1
Ebola Virus Infections	1	1
Escherichia coli Infections	1	1
Foodborne Pathogens: Prevention/Food Preservation	1	1
Fungus Diseases	1	1
Gastric Cancer	1	1
Glioblastoma Multiforme	1	1
HDL: Low	1	1
Helicobacter Pylori Infection	1	1
Hepatitis B	1	1
Herpes Simplex Virus Type 1	1	1
High Homocysteine	1	1
Infection: Antibiotic Resistant	1	1
Ischemia: Myocardial	1	1
Leukemia	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Lymphedema	1	1
Mercury Poisoning	1	1
Mycoplasma Infections	1	1
Neuroblastoma	1	1
Oral Cancer	1	1
Pleurisy	1	1
Pregnancy Complications	1	1
Pulmonary Emphysema	1	1
Radiation	1	1
Respiratory Tract Infections	1	1
Rhabdovirus Infections	1	1
Rotavirus Infections	1	1
Staphylococcal Infections	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Steptococcus Mutans Infections	1	1
Tuberculosis	1	1
Vibrio Infections	1	1

Name	AC	CK
Anti-Inflammatory Agents	86	210
Antioxidants	100	208
Tumor Necrosis Factor (TNF) Alpha Inhibitor	25	76
Hepatoprotective	26	71
Interleukin-6 Downregulation	17	60
Neuroprotective Agents	36	57
Hypolipidemic	12	52
Antiproliferative	29	44
Antihypertensive Agents	11	38
Cyclooxygenase 2 Inhibitors	13	36
Apoptotic	28	35
Interleukin-1 beta downregulation	14	33
Anti-Apoptotic	19	32
Cardioprotective	14	29
NF-kappaB Inhibitor	15	27
Renoprotective	11	25
Hypoglycemic Agents	8	24
Analgesics	6	20
Interleukin-10 upregulation	2	20
Anticholesteremic Agents	5	18
Chemotherapeutic	15	18
Gastrointestinal Agents	5	18
Chemopreventive	9	16
Interleukin-8 downregulation	4	16
Vascular Cell Adhesion Molecule-1 Inhibitor	4	16
Anti-atherogenic	4	14
Antineoplastic Agents	6	14
Chemoprotective Agents	7	13
Anti-metastatic	9	12
Antifungal Agents	3	12
Cell cycle arrest	8	12
Interleukin-17 downregulation	2	12
Superoxide Dismutase Up-regulation	7	12
Anti-Bacterial Agents	9	11
Autophagy Up-regulation	7	11
Immunomodulatory	5	11
Insulin Sensitizers	2	11
Antioxidant	1	10
Antioxidant Effects	1	10
Antiviral Agents	9	10
Calcium Channel Blockers	1	10
Genoprotective	4	10
Hypotensive	1	10
Malondialdehyde Down-regulation	5	10
Gastroprotective	4	8
MicroRNA modulator	7	7
Nrf2 activation	5	7
Antimycobacterial	2	6
Matrix metalloproteinase-1 (MMP-1) inhibitor	2	6
Vasodilator Agents	3	6
Anti-Retroviral Agents	1	5
Cytoprotective	4	5
Interferon-gamma (IFN-gamma) inducer	1	5
Leishmanicidal	2	5
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	5
Radioprotective	3	5
Angiogenesis Inhibitors	3	4
Chemosensitizer	3	4
Enzyme Inhibitors	1	4
Hypnotics and Sedatives	1	4
Matrix metalloproteinase-2 (MMP-2) inhibitor	3	4
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	4
Photoprotective	3	4
Xanthine oxidase inhibitor	1	4
Antimicrobial	3	3
Catalase Up-Regulation	2	3
Cytotoxic	2	3
HIV Fusion Inhibitors	1	3
Interferon Gamma Reducer	2	3
Topoisomerase II Inhibitor	1	3
Vascular Endothelial Growth Factor A Inhibitor	2	3
Anti-Angiogenic	1	2
Anti-Anxiety Agents	1	2
Anti-Platelet	1	2
Anti-Ulcer Agents	1	2
Anticonvulsants	1	2
Antidepressive Agents	1	2
Antimalarials	1	2
Antimutagenic Agents	1	2
Autophagy Inhibitors	1	2
Bax/Bcl2 Ratio: Decrease	1	2
Cardiovascular Agents	1	2
Caspase-3 Inhibition	1	2
Chondroprotective	2	2
Glucagon Like peptide 1 (GLP-1) Up-regulation	1	2
Glutathione Peroxidase 1 (GPx1) Up-Regulation	1	2
Glutathione Upregulation	1	2
HIV-1 Integrase Inhibitor	1	2
Heme oxygenase-1 up-regulation	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	2
Neurogenesis	1	2
Osteoprotective	1	2
Quorum Sensing Inhibition	2	2
Thermogenic	1	2
Vascular Endothelial Growth Factor C Inhibitor	1	2
Vascular Endothelial Growth Factor D Inhibitor	1	2
Wnt/β-catenin pathway down-regulation	1	2
Anti-Glycation Agents	1	1
Anti-HIV Agents	1	1
Anti-Proliferative	1	1
Antinoceceptive	1	1
Antitubercular Agents	1	1
Cyclooxygenase 1 Inhibitor	1	1
Epidermal growth factor receptor (EGFR) inhibitor	1	1
Histone deacetylase inhibitor	1	1
Intercellular adhesion molecule 3 down-regulation	1	1
Interleukin-18 down-regulation	1	1
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	1
PI3K/Akt/signaling suppression	1	1
Pancreato Protective Agents	1	1
Postaglandin PGE2 downregulation	1	1
Proteasome Inhibitors	1	1
Radiosensitizer	1	1
SIRT1 Activator	1	1
Scolicidal	1	1
Tumor Suppressor Protein p53 Upregulation	1	1
apoptosis	1	1

[+]

A combination of olive leaf and fruit extracts may be used efficiently and safely in reducing hypertension and MetS markers.Sep 14, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2020 Sep 15 ;9(9). Epub 2020 Sep 15. PMID: 32942738

Article Published Date : Sep 14, 2020

Study Type : Human Study

Additional Links

Substances : Fruit: All, Olive leaf extract

Diseases : Hypertension

Pharmacological Actions : Antihypertensive Agents

Additional Keywords : Plant Extracts

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2019 Dec 16 ;11(12). Epub 2019 Dec 16. PMID: 31888255

Article Published Date : Dec 15, 2019

Study Type : Human Study

Additional Links

Substances : Grape, Olive leaf extract, Polyphenols

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Interleukin-1 beta downregulation, NF-kappaB Inhibitor

Additional Keywords : Plant Extracts, Proanthocyanidins

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Pubmed Data : Int J Epidemiol. 2002 Apr;31(2):474-80. PMID: 11980820

Article Published Date : Apr 01, 2002

Study Type : Human Study

Additional Links

Substances : Olive

Diseases : Coronary Artery Disease, Myocardial Infarction

Additional Keywords : Risk Reduction

[+]

Olive oil consumption is associated with reduced incidence of ovarian cancer. Jun 01, 2002

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Pubmed Data : Cancer Causes Control. 2002 Jun;13(5):465-70. PMID: 12146851

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Alzheimers Dement (N Y). 2022 ;8(1):e12278. Epub 2022 Mar 13. PMID: 35310529

Article Published Date : Dec 31, 2021

Study Type : Human Study

Additional Links

Substances : Glutathione, Olive

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Omega-3 dietary supplementation may have a therapeutic effect in blepharitis and meibomian gland dysfunction.Jan 01, 2008

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Pubmed Data : Trans Am Ophthalmol Soc. 2008;106:336-56. PMID: 19277245

Article Published Date : Jan 01, 2008

Study Type : Human Study

Additional Links

Substances : Flaxseed, Olive, Omega-3 Fatty Acids

Diseases : Blepharitis, Meibomian gland dysfunction

[+]

Oral supplement containing hydroxytyrosol and punicalagin improves dyslipidemia.Apr 28, 2022

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Pubmed Data : Nutrients. 2017 Apr 15 ;9(4). Epub 2017 Apr 15. PMID: 28420140

Article Published Date : Apr 14, 2017

Study Type : Human Study

Additional Links

Substances : Oleuropein

Diseases : Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-17 downregulation

[+]

Usefulness of extra virgin olive oil minor polar compounds in the management of chronic kidney disease patients.Feb 09, 2021

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Pubmed Data : Nutr Hosp. 2020 Sep 22. Epub 2020 Sep 22. PMID: 32960633

Article Published Date : Sep 21, 2020

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Diabetes Mellitus: Type 2, Hypercholesterolemia

Pharmacological Actions : Anticholesteremic Agents

[+]

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2010 Feb;24(2):163-8. PMID: 18549927

Article Published Date : Feb 01, 2010

Study Type : Animal Study

Additional Links

Substances : Coconut, Coconut Oil, Olive

Diseases : Low Testosterone, Testicular Diseases

[+]

Combined hydroxytyrosol and eicosapentaenoic acid drastically decreases NAFLD development.Dec 31, 2017

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[+]

Effects of emulsion formulations of oleuropein isolated from ethanol extract of olive leaf in diabetic rats.Dec 31, 2019

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Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:8487248. Epub 2018 Apr 26. PMID: 30013722

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation

[+]

EVOO polyphenols relieve synergistically autophagy dysregulation in a cellular model of Alzheimer's disease.Jul 04, 2021

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Pubmed Data : Drug Chem Toxicol. 2018 Nov 14:1-13. Epub 2018 Nov 14. PMID: 30426792

Article Published Date : Nov 13, 2018

Study Type : Animal Study

Additional Links

Substances : Oleuropein, Thymol

Diseases : Drug-Induced Toxicity: Indomethacin, Gastric Ulcer

Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective

Problem Substances : Indomethacin

[+]

Hibiscus sabdariffa and Olive leaf extracts could be useful in the treatment of preclinical hypertension.Apr 30, 2016

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Pubmed Data : J Med Food. 2016 May ;19(5):504-12. PMID: 27152980

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Pubmed Data : Molecules. 2018 Dec 5 ;23(12). Epub 2018 Dec 5. PMID: 30563131

Article Published Date : Dec 04, 2018

Study Type : Animal Study

Additional Links

Substances : Hydroxytyrosol

Diseases : DNA damage, Inflammation, Lipopolysaccharide-Induced Toxicity, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Hydroxytyrosol stimulates neurogenesis in aged dentate gyrus by enhancing stem and progenitor cell proliferation and neuron survival.Feb 05, 2020

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O. europaea extract can be used to decrease some side effects of indomethacin on intestinal tissue.Dec 31, 2019

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Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:6669813. Epub 2020 Dec 23. PMID: 33424990

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Olive

Diseases : Drug-Induced Toxicity: Indomethacin

Pharmacological Actions : Gastroprotective

Problem Substances : Indomethacin

[+]

O. europaea leaves could be used for the management of hypercholesterolemia and atherosclerosis.Oct 03, 2018

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Pubmed Data : Food Chem Toxicol. 2018 Oct 4. Epub 2018 Oct 4. PMID: 30292622

Article Published Date : Oct 03, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Olive leaf extract

Diseases : Atherosclerosis, Hypercholesterolemia

Pharmacological Actions : Hypolipidemic

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OEE and HSE exerted negative inotropic and vasorelaxant effects without any chronotropic property with higher cytoprotective effects and antioxidant activities.Dec 31, 2014

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Pubmed Data : Oxid Med Cell Longev. 2015;2015:318125. Epub 2015 Jun 9. PMID: 26180582

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Hibiscus sabdariffa , Olive leaf extract

Diseases : Hypertension, Oxidative Stress

Pharmacological Actions : Antihypertensive Agents, Antioxidants, Cardiovascular Agents, Cytoprotective, Vasodilator Agents

Additional Keywords : Dose Response, Natural Substance Synergy, Plant Extracts

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Oleuropein ameliorates advanced stage of type 2 diabetes.Jun 21, 2021

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Oleuropein might be a potential useful therapeutic intervention for PTSD.Sep 06, 2017

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Pubmed Data : J Nat Med. 2017 Sep 7. Epub 2017 Sep 7. PMID: 28884427

Article Published Date : Sep 06, 2017

Study Type : Animal Study

Additional Links

Substances : Oleuropein

Diseases : Brain Inflammation , Post-Traumatic Stress Disorders (PTSD)

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

[+]

Oleuropein prevents doxorubicin-induced cardiotoxicity and improves therapeutic outcome. Mar 01, 2007

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Pubmed Data : J Mol Cell Cardiol. 2007 Mar;42(3):549-58. Epub 2007 Jan 16. PMID: 17223128

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Pubmed Data : Anim Cells Syst (Seoul). 2018 ;22(2):109-117. Epub 2018 Mar 13. PMID: 30460087

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Oleuropein

Diseases : Post-Traumatic Stress Disorders (PTSD)

Pharmacological Actions : Anti-Anxiety Agents

[+]

Oleuropein reverses repeated corticosterone-induced depressive-like behaviour.Jan 23, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Antioxidants (Basel). 2021 Oct 6 ;10(10). Epub 2021 Oct 6. PMID: 34679712

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Pubmed Data : Int J Mol Sci. 2018 Dec 30 ;20(1). Epub 2018 Dec 30. PMID: 30598025

Article Published Date : Dec 29, 2018

Study Type : Animal Study

Additional Links

Substances : Oleuropein, Olive

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Olive leaf attenuates early diabetic neuropathic pain through prevention of high glucose-induced cell damage. Apr 22, 2011

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Pubmed Data : J Ethnopharmacol. 2011 Apr 22. Epub 2011 Apr 22. PMID: 21540099

Article Published Date : Apr 22, 2011

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Hyperalgesia, Hyperglycemia, Neuropathic Pain

Pharmacological Actions : Analgesics, Antioxidants, Bax/Bcl2 Ratio: Decrease, Caspase-3 Inhibition

[+]

Olive leaf contains phenolics with radioprotective properties. Jan 01, 1994

Problem Substances : Pesticides

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Olive leaf extract prevents spontaneous occurrence of non-alcoholic fatty liver in rats.Jan 01, 2010

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Pubmed Data : Pathology. 2010 Jan;42(1):66-72. PMID: 20025483

Article Published Date : Jan 01, 2010

Study Type : Animal Study

Additional Links

Substances : Oleuropein, Olive leaf extract

Diseases : Fatty Liver

[+]

Olive leaf extract protects against the genetic and oxidative damage by permethrin in vivo.Jan 20, 2012

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Pubmed Data : Cytotechnology. 2012 Jan 20. Epub 2012 Jan 20. PMID: 22262123

Article Published Date : Jan 20, 2012

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : DNA damage, Oxidative Stress, Pesticide Toxicity: Permethrin

Pharmacological Actions : Antioxidants, Genoprotective

Problem Substances : Permethrin

Adverse Pharmacological Actions : Genotoxic, Oxidant

[+]

Olive leaf extract reduces oxidative stress and oxidative stress-related glucose metabolism disruption induced by 2.45 GHz Wi-Fi signals.Nov 01, 2013

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Pubmed Data : Environ Toxicol Pharmacol. 2013 Nov ;36(3):826-34. Epub 2013 Aug 3. PMID: 23994945

Article Published Date : Nov 01, 2013

Study Type : Animal Study

Olive oil has an inhibitory effect on fibrosis induced by carbon tetrachloride in rat liver.Feb 12, 2010

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Pubmed Data : Altern Ther Health Med. 2017 Jun 23. Epub 2017 Jun 23. PMID: 28646810

Article Published Date : Jun 22, 2017

Study Type : Animal Study

Additional Links

Substances : Oleuropein

Diseases : Breast Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Breast Cancer, Chemosensitizer, Chemotherapeutic Synergy: Doxorubicin, Oleuropein

[+]

The oive oil polyphenol, oleuropein aglycone, exhibits therapeutic properties in a murine model of intestinal ischemia/reperfusion injury.Dec 10, 2012

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Pubmed Data : J Leukoc Biol. 2012 Dec 11. Epub 2012 Dec 11. PMID: 23233730

Article Published Date : Dec 10, 2012

Study Type : Animal Study

Additional Links

Substances : Oleuropein

Diseases : Intestinal Ischemia

[+]

The present study demonstrates the hepato-protective and reno-protective effects of oleuropein and hydroxytyrosol olive leaves extracts from BPA and its derivates toxicity.May 07, 2015

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Pubmed Data : Exp Toxicol Pathol. 2015 May 8. Epub 2015 May 8. PMID: 25963946

Article Published Date : May 07, 2015

Study Type : Animal Study

Additional Links

Substances : Hydroxytyrosol, Oleuropein, Olive leaf extract

Diseases : Bisphenol-A Toxicity

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Bisphenol A

[+]

The results of this study indicate that dry olive leaf extract possesses strong antimelanoma potential.Apr 14, 2011

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Cancer. 2011 Apr 15 ;128(8):1955-65. PMID: 20568104

Article Published Date : Apr 14, 2011

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Chemotherapy-Induced Toxicity, Malignant Melanoma, Melanoma, Skin Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic

Additional Keywords : Natural Substance/Drug Antagonism, Natural Substance/Drug Synergy, Plant Leaves, Temozolomide

Problem Substances : Cisplatin, Doxorubicin, Paclitaxel

[+]

This study indicates a protective effect of olive and thyme phenols supplemented in the diet on α-tocopherol.Feb 12, 2018

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Pubmed Data : Food Funct. 2018 Feb 13. Epub 2018 Feb 13. PMID: 29437171

Article Published Date : Feb 12, 2018

Study Type : Animal Study

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Substances : Olive, Thyme, Vitamin E: alpha tocopherol

Additional Keywords : Natural Substance Synergy

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Thymoquinone and oleuropein significantly decrease serum glucose levels in STZ induced diabetic rats.Sep 30, 2015

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Pubmed Data : Curr Med Chem. 2012 Nov 19. Epub 2012 Nov 19. PMID: 23244583

Article Published Date : Nov 18, 2012

Study Type : Review

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Substances : Hydroxytyrosol

Diseases : Cancers: All

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A diet rich in a variety of fruits, vegetables, whole grains, legumes, oils, and nuts is recommended after a review of various studiesDec 29, 2002

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Pubmed Data : Am J Med. 2002 Dec 30 ;113 Suppl 9B:71S-88S. PMID: 12566142

Article Published Date : Dec 29, 2002

Study Type : Review

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Substances : Carotenoids, Fiber, Isoflavones, Lycopene, Olive, Resveratrol, Stilbenes, Tea

Diseases : Cardiovascular Diseases

Pharmacological Actions : Antioxidants

Additional Keywords : Isothiocyanates

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A Mediterranean diet may protect against homocysteine-induced cardiovascular damage. Sep 01, 2010

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Pubmed Data : Chemosphere. 2010 Sep;81(4):464-8. PMID: 17586618

Article Published Date : Sep 01, 2010

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Molecules. 2015 ;20(7):12992-3004. Epub 2015 Jul 17. PMID: 26193251

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Olive leaf extract

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Plant Extracts

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An olive leaf extract rich in polyphenols promotes apoptosis in cervical cancer cells.Dec 31, 2018

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Pubmed Data : Nutr Cancer. 2019 ;71(2):320-333. Epub 2019 Jan 19. PMID: 30661406

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Pubmed Data : Infect Drug Resist. 2020 ;13:3501-3511. Epub 2020 Oct 8. PMID: 33116669

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Tyrosol

Diseases : Pseudomonas aeruginosa

Pharmacological Actions : Anti-Bacterial Agents, Quorum Sensing Inhibition

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Bromelain and Olea europaea (L.) leaf extract mediated alleviation of benzo(a)pyrene induced lung cancer.Apr 22, 2021

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Pubmed Data : Environ Sci Pollut Res Int. 2021 Apr 23. Epub 2021 Apr 23. PMID: 33893581

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Food supplements based on palmitoylethanolamide plus hydroxytyrosol from olive tree or Bacopa monnieri extracts for neurological diseases.Jan 08, 2020

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Pubmed Data : Acta Biomed. 2020 11 9 ;91(13-S):e2020007. Epub 2020 Nov 9. PMID: 33170159

Article Published Date : Jan 08, 2020

Study Type : Review

Additional Links

Substances : Hydroxytyrosol, Palmitoylethanolamide

Diseases : Brain Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

Additional Keywords : Plant Extracts

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Generally used nutritional extracts of these plants have in vitro antiviral activity against rotavirus.Jul 25, 2012

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Pubmed Data : Virol J. 2012 Jul 26 ;9:137. Epub 2012 Jul 26. PMID: 22834653

Article Published Date : Jul 25, 2012

Study Type : In Vitro Study

Additional Links

Substances : Licorice, Lotus , Nettle, Olive, Rooibos

Diseases : Rotavirus Infections

Pharmacological Actions : Antiviral Agents

Additional Keywords : Antiviral Agents, Licorice, Lotus, Natural Substance Synergy, nettle, Olive, Plant Extracts, Rooibos, Rotavirus Infections

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Hydroxytyrosol and oleuropein inhibit migration and invasion in ER-positive breast cancer cell lines (MCF7 and T47D).Apr 13, 2020

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Pubmed Data : Nutr Cancer. 2020 Apr 14:1-11. Epub 2020 Apr 14. PMID: 32286090

Article Published Date : Apr 13, 2020

Study Type : In Vitro Study

Additional Links

Substances : Hydroxytyrosol, Oleuropein

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic, Autophagy Inhibitors

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View the Evidence: 445 Abstracts with Olive Research

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A combination of olive leaf and fruit extracts may be used efficiently and safely in reducing hypertension and MetS markers.Sep 14, 2020

A combination of garlic, mullein, calendula, st. johns wort and olive oil is as effective as an anesthetic drug for the management of acute otitis media-associated pain. Jul 01, 2001

A combination of hydroxytyrosol, omega-3 fatty acids and curcumin improves pain and inflammation among early stage breast cancer patients.Mar 31, 2019

A combination of red yeast rice and olive extract in high-risk hypercholesterolemic patients, without inducing new-onset SAMS.Nov 30, 2017

A Mediterranean diet (that emphasizes olive oil, fiber, fruits, vegetables, fish and alcohol and reduces meat/meat products) can be an effective measure for reducing the risk of myocardial infarction.Apr 01, 2005

A Mediterranean diet rich in olive oil may have a protective role in multiple sclerosis. Jun 01, 2009

A Mediterranean diet rich in virgin olive oil is associated with high plasma antioxidant capacity and reduced body weight gain.Dec 01, 2009

A mixture of honey, olive oil and beeswax is safe and effective for hemorrhoids and anal fissure.Feb 02, 2006

A mixture of natural honey, beeswax and olive oil appears useful in the management of dermatitis and psoriasis vulgaris.Dec 01, 2003

A nut-enriched diet has cholesterol-lowering properties, and olive oil has a cholesterol-lowering property independent of its fatty acid content. May 31, 2011

A red yeast rice-olive extract supplement reduces biomarkers of oxidative stress, OxLDL and Lp-PLA2, in subjects with metabolic syndrome.Jul 02, 2017

A standardized extract of Opuntia ficus-indica (L.) Mill and Olea europaea L. improves gastrointestinal discomfort.Mar 15, 2021

Adherence to a diet comprising mostly fruits, vegetables, fish, and olive/sunflower oil, along with avoidance of Western-type foods, may contribute to a substantial reduction in postmenopausal breast cancer risk.Nov 15, 2009

Adherence to a Mediterranean dietary pattern may protect against coronary artery wall production of inflammatory mediators in patients with unstable angina pectoris. Sep 01, 2005

Administration of olive oil followed by a low volume of polyethylene glycol-electrolyte lavage solution improves patient satisfaction with right-side colonic cleansing over conventional preparation. Sep 01, 2009

An onion-olive-oil combination reduces arterial blood pressure, plasma viscosity and hematocrit, indicating the cardiovascular benefits of a Mediterranean diet. Sep 01, 2000

Antioxidant activity of hydroxytyrosol and vitamin E reduces systemic inflammation in children with paediatric NAFLD.Oct 11, 2020

Chondroprotective properties of human-enriched serum following polyphenol extract absorption.Dec 15, 2019

Extra virgin olive oil mitigates postprandial lipopolysaccharide-induced inflammation and oxidative stress.Mar 01, 2019

Food fried in extra-virgin olive oil improves postprandial insulin response in obese, insulin-resistant women.Dec 13, 2010

Hibiscus sabdariffa and Olea europaea had comparable antihypertensive efficacy and safety to captopril in Egyptian patients with grade 1 hypertension.Jul 28, 2020

Hydroxytyrosol changed body composition parameters and modulated the antioxidant profile, the expression of inflammation and oxidative stress-related genes.Dec 31, 2016

Hydroxytyrosol is effective and safe in preventing recurrent candida episodes.Jun 30, 2020

Mediterranean diets supplemented with olive oil or nuts have beneficial effects on cardiovascular risk factors.Jul 04, 2006

Mucosave formulation is an effective treatment for reducing the frequency and intensity of symptoms associated with gastroesophageal reflux.Dec 31, 2015

Naturopathic treatment for ear pain is demonstrated superior to antibiotic treatment.May 01, 2003

OLE prevents the loss of muscle mass associated with aging and exerts anti-inflammatory and insulin-sensitizing effects on adipose tissue and skeletal muscle.May 06, 2021

Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men.Dec 31, 2012

Olive (Olea europaea) leaf extract, at the dosage regimen of 500 mg twice daily, was similarly effective in lowering systolic and diastolic blood pressures in subjects with stage-1 hypertension as Captopril, given at its effective dose of 12.5-25 mg twiceFeb 14, 2011

Olive fruit and almond skin extract seems to protect LDL from oxidation and to prevent inflammatory status in moderately hypercholesterolemic subjects.Aug 17, 2020

Olive leaf extract has a beneficial effects on upper respiratory illness in high school athletes. Feb 08, 2019

Olive leaf extract has calcium channel blocking activity consistent with its traditional role in the treatment of cardiovascular disease. Nov 20, 2008

Olive leaf tea is beneficial for lipid metabolism in adults with prediabetes.May 10, 2019

Olive oil consumption appears to reduce the risk of non-fatal heart attack in coronary disease. Apr 01, 2002

Olive oil consumption is associated with reduced incidence of ovarian cancer. Jun 01, 2002

Olive oil consumption reduces the susceptibility of LDL to oxidation, supporting the hypothesis that daily virgin olive oil intake protects cardiovascular health. Dec 01, 2007

Olive oil during pregnancy is associated with reduced wheezing during the first year of life of the offspring.Apr 01, 2010

Olive polyphenols and bioavailable glutathione: Promising results in patients diagnosed with mild Alzheimer's disease.Dec 31, 2021

Omega-3 dietary supplementation may have a therapeutic effect in blepharitis and meibomian gland dysfunction.Jan 01, 2008

Oral supplement containing hydroxytyrosol and punicalagin improves dyslipidemia.Apr 28, 2022

Our results support the protective role of olive oil consumption on breast cancer among Canaries women.Feb 01, 2006

Supplementation with hydroxytyrosol and punicalagin improves early atherosclerosis markers.Mar 15, 2019

Supplementation with omega-3 fatty acids in pregnancy is associated with increased omega-3 fatty acids in breast milk and is positively associated with infant DHA status at 1 y.Dec 01, 2007

The combination of D-mannose, inulin, cranberry, bearberry, Olea europaea, Orthosiphon and Lactobacillus acidophilus SGL 11 per os represents a useful therapy for recurrent UTIs.Aug 31, 2020

The consumption of vegetables and fruits are inversely, significantly and strongly associated with breast cancer risk. There also is evidence that olive oil consumption may reduce the risk of breast cancer. Jan 18, 1995

The effect of dietary intervention with high-oleocanthal and oleacein olive oil in Patients with early-stage chronic lymphocytic leukemia.Dec 31, 2020

The results concluded that inflammation as a major cause of hypertension was significantly decreased in patients using olive leaf extract tablets.Dec 31, 2018

The topical application of a honey, olive oil and beeswax mixture has therapeutic effects in patients with Pityriasis Versicolor and Tinea. Mar 01, 2004

The topical application of honey, olive oil and beeswax has benefits in diaper dermatitis.Feb 01, 2005

These findings indicate that oleuropein improves postprandial glycaemic profile via hampering Nox2-derived oxidative stress.Mar 25, 2018

These new data support a potential role of oleuropein in the treatment of ulcerative colitis.Apr 14, 2017

Usefulness of extra virgin olive oil minor polar compounds in the management of chronic kidney disease patients.Feb 09, 2021

Vitamin E and hydroxytyrosol may be a promising strategy that could be easily diet integrated to improve NAFLD-related liver damage in children.Feb 10, 2019

5-Hydroxytyrosol inhibits HIV-1 replication in primary cells of the lower and upper female reproductive tract.Dec 31, 2016

Ethanol extract of olive leaf extract induced its genoprotective effect via the increase in the antioxidant capacity, inhibition of oxidative stress and scavenging of free radicals.Oct 01, 2011

Hydroxytyrosol as a promising ally in the treatment of fibromyalgia.Aug 08, 2020

OLE may promote the brown remodelling of white adipose tissue inducing thermogenesis and improving metabolic homeostasis.Dec 31, 2015

Oleuropein is effective in antimycoplasmal activity.Oct 01, 2002

Oleuropein might provide a basis for developing a new dietary strategy for the prevention and management of rheumatoid arthritis.Apr 19, 2017

Olive leaf extracts act as modulators of the human immune response.Nov 14, 2017

Effect of oleuropein on oxidative stress, inflammation and apoptosis induced by ischemia-reperfusion injury in rat kidney.Aug 14, 2020

Hydroxytyrosol ameliorates oxidative challenge and inflammatory response associated with lipopolysaccharide-mediated sepsis.Aug 24, 2020

Oleuropein protects against lipopolysaccharide-induced sepsis and alleviates inflammatory responses in mice.Jul 24, 2020

A combination of Olea europaea leaf extract and Spirodela polyrhiza extract alleviates atopic dermatitis.Nov 04, 2020

Administration of olive leaf and hydroxytyrosol extracts significantly improved the antioxidant state in asthma disease.Oct 22, 2019

Ameliorative effects of oleuropein on lipopolysaccharide-induced acute lung injury.Sep 12, 2021

An oleuropein rich-olive (Olea europaea L.) leaf extract reduces β-amyloid and tau proteotoxicity.Mar 07, 2022

An oleuropein-enriched olive leaf extract exerted antihypertensive effects on genetic hypertension related to the improvement of vascular function.Nov 22, 2015

Anti-inflammatory and anti-oxidant activity of Hidroxin in rotenone-induced Parkinson's disease.Sep 02, 2020

Antidiabetic effect of olive leaf extract on streptozotocin-induced diabetes mellitus.Sep 21, 2020

Antioxidant and anti-inflammatory effect of olive leaf extract treatment in diabetic rat brain.Jun 16, 2021

Biochemical evaluation of the antioxidant effects of hydroxytyrosol on pancreatitis-associated gut injury.Aug 21, 2020

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View the Evidence:
445 Abstracts with Olive Research