Olive

Name	AC	CK
Oxidative Stress	32	90
Hypertension	11	71
Inflammation	27	68
Cardiovascular Diseases	16	58
Breast Cancer	20	43
Diabetes Mellitus: Type 2	15	33
Obesity	11	33
Upper Respiratory Infections	1	30
Insulin Resistance	6	28
Myocardial Infarction	5	27
Nonalcoholic fatty liver disease (NAFLD)	6	27
Lipopolysaccharide-Induced Toxicity	10	25
Arteriosclerosis	7	21
High Cholesterol	3	21
Breast Cancer: Prevention	2	20
Cancers: All	16	20
Ear Infection	2	20
Gastroesophageal Reflux	2	20
Cholesterol: Oxidation	7	19
Colon Cancer	10	17
DNA damage	7	16
High Fat Diet	8	16
Alzheimer's Disease	9	15
Atherosclerosis	5	15
Chemically-Induced Liver Damage	6	14
Hypercholesterolemia	3	14
HIV Infections	6	13
Hyperglycemia	3	13
Metabolic Syndrome X	4	13
Multiple Sclerosis	3	13
Clotting	2	12
Lipid Peroxidation	2	12
Parkinson's Disease	9	12
Ovarian Cancer	2	11
Anal Fissure	1	10
Angina Pectoris	1	10
Blepharitis	1	10
Blood Coagulation Disorders	1	10
Breast Milk: Inadequate/Poor Quality	1	10
C-Reactive Protein	1	10
Candidiasis: Vulvovaginal	1	10
Chemotherapy-Induced Toxicity: Cisplatin	5	10
Colitis	6	10
Constipation	1	10
Coronary Artery Disease	1	10
Cystitis	1	10
Dermatitis	1	10
Diaper Rash	1	10
Dyslipidemias	1	10
Infant Care	1	10
Meibomian gland dysfunction	1	10
Otitis media	1	10
Pityriasis Versicolor	1	10
Prediabetes	1	10
Prenatal Nutrition: Health of the Offspring	1	10
Prenatal Nutrition: Prevention of Problems	1	10
Psoriasis	1	10
Statin-Induced Pathologies	1	10
Tinea	1	10
Ulcerative Colitis	1	10
Urinary Tract Infections	1	10
Weight Problems	1	10
Wheezing: Infants	1	10
Neurodegenerative Diseases	9	9
Ultraviolet Radiation Induced Damage	4	9
Sepsis	4	8
Skin Diseases: Photo-Aging	3	8
Cognitive Decline/Dysfunction	4	7
Kidney Damage	4	7
Melanoma	5	7
Bisphenol-A Toxicity	1	6
Brain Inflammation	4	6
Brain: Oxidative Stress	4	6
Chemotherapy-Induced Toxicity	3	6
Chemotherapy-Induced Toxicity: Doxorubicin	3	6
Diabetes Mellitus: Type 1	2	6
Drug-Induced Toxicity: Indomethacin	3	6
Fatty Liver	2	6
Liver Fibrosis	3	6
Liver Steatosis	3	6
Mycobacterium Infections	2	6
Myocardial Ischemia	3	6
Prostate Cancer	4	6
Rheumatoid Arthritis	2	6
Skin Cancer	2	6
Asthma	2	5
Endothelial Dysfunction	3	5
Fibromyalgia	1	5
Hydrogen Peroxide Induced Toxicity	4	5
Hyperlipidemia	3	5
Inflammatory Bowel Diseases	3	5
Leishmaniasis	2	5
Liver Damage	3	5
Osteoarthritis	4	5
Osteoporosis	3	5
Arsenic Poisoning	2	4
Bisphenol Toxicity	1	4
Breast Cancer: Triple Negative	3	4
Cardiotoxicity: Chemotherapy-Induced	2	4
Chemotherapy and Radiation Toxicity	2	4
Diabetic Complications	2	4
Glioblastoma	4	4
Gout	1	4
Hyperuricemia	1	4
Insomnia	1	4
Ischemia	2	4
Kidney Damage: Chemically-Induced	2	4
Lead Poisoning	2	4
Liver Cancer	4	4
Opiate Tolerance	1	4
Post-Traumatic Stress Disorders (PTSD)	2	4
Pseudomonas aeruginosa	3	4
Staphylococcus aureus infection	4	4
Cadmium Poisoning	2	3
Colorectal Cancer	3	3
Mitochondrial Dysfunction	2	3
Neuropathic Pain	2	3
Pain	2	3
Pancreatic Cancer	2	3
Acquired Immunodeficiency Syndrome	2	2
Aging	1	2
Air Pollution Linked Toxicity	1	2
Alcohol Toxicity	1	2
Athletic Performance	1	2
Atopic Dermatitis	1	2
Autoimmune Diseases	1	2
Brain Ischemia	1	2
Cancer Metastasis	1	2
Cerebral Ischemia	1	2
Cerebral Stroke	1	2
Cervical Cancer	2	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Cholesterol: LDL/HDL ratio	1	2
Colorectal Cancer: Prevention	1	2
Depression	1	2
Diabetes: Oxidative Stress	1	2
Diabetic Retinopathy	1	2
Dysbiosis	1	2
Erythema	1	2
Esophageal Cancer	1	2
Fibrinogen: Elevated	1	2
Gastric Ulcer	1	2
Gastritis	1	2
Gastrointestinal Inflammation	1	2
Glioma	2	2
Gram-Positive Bacterial Infections	1	2
Heart Failure	1	2
Hyperalgesia	1	2
Infants: Low Birth Weight	1	2
Influenza	2	2
Intestinal Ischemia	1	2
Intracerebral Hemorrhage	1	2
Liver Cirrhosis	1	2
Liver Damage: Drug-Induced	1	2
Low Testosterone	1	2
Lung Cancer	2	2
Lung Injury: Acute	1	2
Malaria	1	2
Malignant Melanoma	1	2
Mastitis	1	2
Mesothelioma	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Mycotoxin Toxicity	1	2
Myocarditis: Autoimmune	1	2
Osteoporosis: Age-Related	1	2
Osteosarcoma	1	2
Pancreatitis	1	2
Periodontitis	1	2
Pesticide Toxicity: Permethrin	1	2
Prehypertension	1	2
Promyelocytic leukemia	2	2
Radiation Induced Illness	1	2
Seizures	1	2
Stroke: Ischemic	1	2
Sunburn	1	2
Testicular Diseases	1	2
Thrombosis	1	2
Triglycerides: Elevated	1	2
Tumors	1	2
Wound Healing	2	2
Advanced Glycation End products (AGE)	1	1
Amyloidosis	1	1
Bladder Cancer	1	1
Blue Light Toxicity	1	1
Breast Cancer: Bone Metastasis	1	1
Campylobacter Infections	1	1
Cancers: Drug Resistant	1	1
Candida Infection	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	1
Chronic Kidney Disease (CKD)	1	1
Chronic Myeloid Leukemia	1	1
Chronic Obstructive Pulmonary Disease	1	1
Common Cold	1	1
Coronavirus Infection	1	1
Dementia	1	1
Dementia: Alzheimer Type	1	1
Drug-Induced Toxicity: L-Thyroxine	1	1
Ebola Virus Infections	1	1
Escherichia coli Infections	1	1
Foodborne Pathogens: Prevention/Food Preservation	1	1
Fungus Diseases	1	1
Gastric Cancer	1	1
Glioblastoma Multiforme	1	1
HDL: Low	1	1
Helicobacter Pylori Infection	1	1
Hepatitis B	1	1
Herpes Simplex Virus Type 1	1	1
High Homocysteine	1	1
Infection: Antibiotic Resistant	1	1
Ischemia: Myocardial	1	1
Leukemia	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Lymphedema	1	1
Mercury Poisoning	1	1
Mycoplasma Infections	1	1
Neuroblastoma	1	1
Oral Cancer	1	1
Pleurisy	1	1
Pregnancy Complications	1	1
Pulmonary Emphysema	1	1
Radiation	1	1
Respiratory Tract Infections	1	1
Rhabdovirus Infections	1	1
Rotavirus Infections	1	1
Staphylococcal Infections	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Steptococcus Mutans Infections	1	1
Tuberculosis	1	1
Vibrio Infections	1	1

Name	AC	CK
Anti-Inflammatory Agents	86	210
Antioxidants	100	208
Tumor Necrosis Factor (TNF) Alpha Inhibitor	25	76
Hepatoprotective	26	71
Interleukin-6 Downregulation	17	60
Neuroprotective Agents	36	57
Hypolipidemic	12	52
Antiproliferative	29	44
Antihypertensive Agents	11	38
Cyclooxygenase 2 Inhibitors	13	36
Apoptotic	28	35
Interleukin-1 beta downregulation	14	33
Anti-Apoptotic	19	32
Cardioprotective	14	29
NF-kappaB Inhibitor	15	27
Renoprotective	11	25
Hypoglycemic Agents	8	24
Analgesics	6	20
Interleukin-10 upregulation	2	20
Anticholesteremic Agents	5	18
Chemotherapeutic	15	18
Gastrointestinal Agents	5	18
Chemopreventive	9	16
Interleukin-8 downregulation	4	16
Vascular Cell Adhesion Molecule-1 Inhibitor	4	16
Anti-atherogenic	4	14
Antineoplastic Agents	6	14
Chemoprotective Agents	7	13
Anti-metastatic	9	12
Antifungal Agents	3	12
Cell cycle arrest	8	12
Interleukin-17 downregulation	2	12
Superoxide Dismutase Up-regulation	7	12
Anti-Bacterial Agents	9	11
Autophagy Up-regulation	7	11
Immunomodulatory	5	11
Insulin Sensitizers	2	11
Antioxidant	1	10
Antioxidant Effects	1	10
Antiviral Agents	9	10
Calcium Channel Blockers	1	10
Genoprotective	4	10
Hypotensive	1	10
Malondialdehyde Down-regulation	5	10
Gastroprotective	4	8
MicroRNA modulator	7	7
Nrf2 activation	5	7
Antimycobacterial	2	6
Matrix metalloproteinase-1 (MMP-1) inhibitor	2	6
Vasodilator Agents	3	6
Anti-Retroviral Agents	1	5
Cytoprotective	4	5
Interferon-gamma (IFN-gamma) inducer	1	5
Leishmanicidal	2	5
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	5
Radioprotective	3	5
Angiogenesis Inhibitors	3	4
Chemosensitizer	3	4
Enzyme Inhibitors	1	4
Hypnotics and Sedatives	1	4
Matrix metalloproteinase-2 (MMP-2) inhibitor	3	4
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	4
Photoprotective	3	4
Xanthine oxidase inhibitor	1	4
Antimicrobial	3	3
Catalase Up-Regulation	2	3
Cytotoxic	2	3
HIV Fusion Inhibitors	1	3
Interferon Gamma Reducer	2	3
Topoisomerase II Inhibitor	1	3
Vascular Endothelial Growth Factor A Inhibitor	2	3
Anti-Angiogenic	1	2
Anti-Anxiety Agents	1	2
Anti-Platelet	1	2
Anti-Ulcer Agents	1	2
Anticonvulsants	1	2
Antidepressive Agents	1	2
Antimalarials	1	2
Antimutagenic Agents	1	2
Autophagy Inhibitors	1	2
Bax/Bcl2 Ratio: Decrease	1	2
Cardiovascular Agents	1	2
Caspase-3 Inhibition	1	2
Chondroprotective	2	2
Glucagon Like peptide 1 (GLP-1) Up-regulation	1	2
Glutathione Peroxidase 1 (GPx1) Up-Regulation	1	2
Glutathione Upregulation	1	2
HIV-1 Integrase Inhibitor	1	2
Heme oxygenase-1 up-regulation	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	2
Neurogenesis	1	2
Osteoprotective	1	2
Quorum Sensing Inhibition	2	2
Thermogenic	1	2
Vascular Endothelial Growth Factor C Inhibitor	1	2
Vascular Endothelial Growth Factor D Inhibitor	1	2
Wnt/β-catenin pathway down-regulation	1	2
Anti-Glycation Agents	1	1
Anti-HIV Agents	1	1
Anti-Proliferative	1	1
Antinoceceptive	1	1
Antitubercular Agents	1	1
Cyclooxygenase 1 Inhibitor	1	1
Epidermal growth factor receptor (EGFR) inhibitor	1	1
Histone deacetylase inhibitor	1	1
Intercellular adhesion molecule 3 down-regulation	1	1
Interleukin-18 down-regulation	1	1
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	1
PI3K/Akt/signaling suppression	1	1
Pancreato Protective Agents	1	1
Postaglandin PGE2 downregulation	1	1
Proteasome Inhibitors	1	1
Radiosensitizer	1	1
SIRT1 Activator	1	1
Scolicidal	1	1
Tumor Suppressor Protein p53 Upregulation	1	1
apoptosis	1	1

[+]

The effects of olive leaf extract on cardiovascular risk factors in the general adult population.Oct 20, 2022

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Pubmed Data : Diabetol Metab Syndr. 2022 Oct 21 ;14(1):151. Epub 2022 Oct 21. PMID: 36271405

Article Published Date : Oct 20, 2022

Study Type : Meta Analysis, Review

Additional Links

Substances : Olive leaf extract

Diseases : Cardiovascular Diseases

Pharmacological Actions : Cardioprotective

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A combination of olive leaf and fruit extracts may be used efficiently and safely in reducing hypertension and MetS markers.Sep 14, 2020

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Pubmed Data : Antioxidants (Basel). 2020 Sep 15 ;9(9). Epub 2020 Sep 15. PMID: 32942738

Article Published Date : Sep 14, 2020

Study Type : Human Study

Additional Links

Substances : Fruit: All, Olive leaf extract

Diseases : Hypertension

Pharmacological Actions : Antihypertensive Agents

Additional Keywords : Plant Extracts

[+]

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2019 Dec 16 ;11(12). Epub 2019 Dec 16. PMID: 31888255

Article Published Date : Dec 15, 2019

Study Type : Human Study

Additional Links

Substances : Grape, Olive leaf extract, Polyphenols

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Interleukin-1 beta downregulation, NF-kappaB Inhibitor

Additional Keywords : Plant Extracts, Proanthocyanidins

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Pubmed Data : Int J Epidemiol. 2002 Apr;31(2):474-80. PMID: 11980820

Article Published Date : Apr 01, 2002

Study Type : Human Study

Additional Links

Substances : Olive

Diseases : Coronary Artery Disease, Myocardial Infarction

Additional Keywords : Risk Reduction

[+]

Olive oil consumption is associated with reduced incidence of ovarian cancer. Jun 01, 2002

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Pubmed Data : Cancer Causes Control. 2002 Jun;13(5):465-70. PMID: 12146851

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Pubmed Data : Alzheimers Dement (N Y). 2022 ;8(1):e12278. Epub 2022 Mar 13. PMID: 35310529

Article Published Date : Dec 31, 2021

Study Type : Human Study

Additional Links

Substances : Glutathione, Olive

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Omega-3 dietary supplementation may have a therapeutic effect in blepharitis and meibomian gland dysfunction.Jan 01, 2008

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Pubmed Data : Trans Am Ophthalmol Soc. 2008;106:336-56. PMID: 19277245

Article Published Date : Jan 01, 2008

Study Type : Human Study

Additional Links

Substances : Flaxseed, Olive, Omega-3 Fatty Acids

Diseases : Blepharitis, Meibomian gland dysfunction

[+]

Oral supplement containing hydroxytyrosol and punicalagin improves dyslipidemia.Apr 28, 2022

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Pubmed Data : J Natl Cancer Inst. 1995 Jan 18;87(2):110-6. PMID: 7503842

Article Published Date : Jan 18, 1995

Study Type : Human Study

Additional Links

Substances : Fruit: All, Olive, Olive Oil, Vegetables: All

Diseases : Breast Cancer: Prevention

Additional Keywords : Inverse Relationship, Risk Reduction

[+]

The effect of dietary intervention with high-oleocanthal and oleacein olive oil in Patients with early-stage chronic lymphocytic leukemia.Dec 31, 2020

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Pubmed Data : Nutrients. 2017 Apr 15 ;9(4). Epub 2017 Apr 15. PMID: 28420140

Article Published Date : Apr 14, 2017

Study Type : Human Study

Additional Links

Substances : Oleuropein

Diseases : Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-17 downregulation

[+]

Topical rosemary essential oil increased warmth perception in patients with systemic sclerosis-related Raynaud's phenomenon.Dec 31, 2021

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Pubmed Data : Complement Med Res. 2022 ;29(3):242-248. Epub 2022 Feb 9. PMID: 35139518

Article Published Date : Dec 31, 2021

Study Type : Human Study

Additional Links

Substances : Olive, Rosemary

Diseases : Raynaud Disease

[+]

Usefulness of extra virgin olive oil minor polar compounds in the management of chronic kidney disease patients.Feb 09, 2021

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Pubmed Data : Phytother Res. 2022 Oct ;36(10):4002-4013. Epub 2022 Aug 10. PMID: 36222190

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Pubmed Data : Food Funct. 2016 Nov 21. Epub 2016 Aug 21. PMID: 27869910

[+]

Effects of emulsion formulations of oleuropein isolated from ethanol extract of olive leaf in diabetic rats.Dec 31, 2019

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Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:8487248. Epub 2018 Apr 26. PMID: 30013722

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation

[+]

EVOO polyphenols relieve synergistically autophagy dysregulation in a cellular model of Alzheimer's disease.Jul 04, 2021

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Pubmed Data : Drug Chem Toxicol. 2018 Nov 14:1-13. Epub 2018 Nov 14. PMID: 30426792

Article Published Date : Nov 13, 2018

Study Type : Animal Study

Additional Links

Substances : Oleuropein, Thymol

Diseases : Drug-Induced Toxicity: Indomethacin, Gastric Ulcer

Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective

Problem Substances : Indomethacin

[+]

Hibiscus sabdariffa and Olive leaf extracts could be useful in the treatment of preclinical hypertension.Apr 30, 2016

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Pubmed Data : J Med Food. 2016 May ;19(5):504-12. PMID: 27152980

Hydroxytyrosol and olive leaf extract exert cardioprotective effects by inhibiting GRP78 and CHOP expression.Dec 31, 2016

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Pubmed Data : J Biomed Res. 2017 11 1. Epub 2017 Nov 1. PMID: 29760296

Article Published Date : Dec 31, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Hydroxytyrosol, Olive leaf extract

Diseases : Myocardial Infarction

Pharmacological Actions : Cardioprotective

[+]

Hydroxytyrosol as anti-parkinsonian molecule.Apr 17, 2021

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Pubmed Data : Molecules. 2018 Dec 5 ;23(12). Epub 2018 Dec 5. PMID: 30563131

Article Published Date : Dec 04, 2018

Study Type : Animal Study

Additional Links

Substances : Hydroxytyrosol

Diseases : DNA damage, Inflammation, Lipopolysaccharide-Induced Toxicity, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Hydroxytyrosol stimulates neurogenesis in aged dentate gyrus by enhancing stem and progenitor cell proliferation and neuron survival.Feb 05, 2020

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O. europaea extract can be used to decrease some side effects of indomethacin on intestinal tissue.Dec 31, 2019

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Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:6669813. Epub 2020 Dec 23. PMID: 33424990

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Olive

Diseases : Drug-Induced Toxicity: Indomethacin

Pharmacological Actions : Gastroprotective

Problem Substances : Indomethacin

[+]

O. europaea leaves could be used for the management of hypercholesterolemia and atherosclerosis.Oct 03, 2018

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Pubmed Data : Food Chem Toxicol. 2018 Oct 4. Epub 2018 Oct 4. PMID: 30292622

Article Published Date : Oct 03, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Olive leaf extract

Diseases : Atherosclerosis, Hypercholesterolemia

Pharmacological Actions : Hypolipidemic

[+]

OEE and HSE exerted negative inotropic and vasorelaxant effects without any chronotropic property with higher cytoprotective effects and antioxidant activities.Dec 31, 2014

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Pubmed Data : Oxid Med Cell Longev. 2015;2015:318125. Epub 2015 Jun 9. PMID: 26180582

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Hibiscus sabdariffa , Olive leaf extract

Diseases : Hypertension, Oxidative Stress

Pharmacological Actions : Antihypertensive Agents, Antioxidants, Cardiovascular Agents, Cytoprotective, Vasodilator Agents

Additional Keywords : Dose Response, Natural Substance Synergy, Plant Extracts

[+]

Olea europaea leaf extract ameliorates learning and memory deficits in streptozotocin-induced diabetic rats.Feb 28, 2022

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Pubmed Data : J Clin Biochem Nutr. 2017 Nov ;61(3):196-202. Epub 2017 Oct 3. PMID: 29203961

Article Published Date : Oct 31, 2017

Study Type : Animal Study

Additional Links

Substances : Oleuropein

Diseases : Diabetes Mellitus: Type 2, Insulin Resistance

[+]

Oleuropein could be used in the prevention of cadmium hepatotoxicity.Dec 31, 2019

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Pubmed Data : Biomed Res Int. 2020 ;2020:4398924. Epub 2020 Apr 3. PMID: 32337247

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Pubmed Data : Anim Cells Syst (Seoul). 2018 ;22(2):109-117. Epub 2018 Mar 13. PMID: 30460087

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Oleuropein

Diseases : Post-Traumatic Stress Disorders (PTSD)

Pharmacological Actions : Anti-Anxiety Agents

[+]

Oleuropein reverses repeated corticosterone-induced depressive-like behaviour.Jan 23, 2020

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Pubmed Data : Antioxidants (Basel). 2021 Oct 6 ;10(10). Epub 2021 Oct 6. PMID: 34679712

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Pubmed Data : Iran J Kidney Dis. 2012 Jan ;6(1):25-32. PMID: 22218116

Article Published Date : Jan 01, 2012

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Chemotherapy-Induced Toxicity: Gentamicin

Pharmacological Actions : Antioxidants, Glutathione Upregulation , Renoprotective

Problem Substances : Gentamicin

Adverse Pharmacological Actions : Nephrotoxic, Oxidant

[+]

Olive leaf extract and glutamine significantly increase GLP-1 up-regulation. Sep 01, 2011

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Pubmed Data : Sci Pharm. 2011 Sep ;79(3):615-621. Epub 2011 Jun 9. PMID: 21886907

Article Published Date : Sep 01, 2011

Study Type : Animal Study

Additional Links

Substances : Glutamine, Olive leaf extract

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Glucagon Like peptide 1 (GLP-1) Up-regulation

[+]

Olive leaf extract attenuates chlorpyrifos-induced neuro-and reproductive toxicity.Sep 26, 2022

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Pubmed Data : Life (Basel). 2022 Sep 27 ;12(10). Epub 2022 Sep 27. PMID: 36294935

Article Published Date : Sep 26, 2022

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Pesticide Toxicity

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Problem Substances : Chlorpyrifos

[+]

Olive leaf extract can inhibit lead-induced brain injury by increasing antioxidant capacity and reducing apoptosis.Aug 04, 2013

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Pubmed Data : Neural Regen Res. 2013 Aug 5 ;8(22):2021-9. PMID: 25206510

Article Published Date : Aug 04, 2013

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Brain: Oxidative Stress, Lead Poisoning, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Catalase Up-Regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation

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[+]

Olive leaf extract is a promising chemotherapeutic agent for reducing the toxicity of carbendazim and possibly other pesticides and toxicants.Apr 01, 2011

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Pubmed Data : Eur Rev Med Pharmacol Sci. 2011 Apr ;15(4):413-26. PMID: 21608437

Article Published Date : Apr 01, 2011

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Therapeutic Actions : anti-cancer, anti-carcinogenic role

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Anti-cancer, Olive Leaf Extract, Phytotherapy, Plant Extracts

Problem Substances : Pesticides

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[+]

Olive leaf extract prevents spontaneous occurrence of non-alcoholic fatty liver in rats.Jan 01, 2010

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Pubmed Data : Pathology. 2010 Jan;42(1):66-72. PMID: 20025483

Article Published Date : Jan 01, 2010

Study Type : Animal Study

Additional Links

Substances : Oleuropein, Olive leaf extract

Diseases : Fatty Liver

[+]

Olive leaf extract protect against L-arginine induced chronic pancreatitis.Jun 29, 2022

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Pubmed Data : Anat Cell Biol. 2022 Jun 30 ;55(2):205-216. PMID: 35773220

Article Published Date : Jun 29, 2022

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Pancreatitis: Chronic

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants

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Olive leaf extract protects against the genetic and oxidative damage by permethrin in vivo.Jan 20, 2012

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Pubmed Data : Cytotechnology. 2012 Jan 20. Epub 2012 Jan 20. PMID: 22262123

Article Published Date : Jan 20, 2012

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : DNA damage, Oxidative Stress, Pesticide Toxicity: Permethrin

Pharmacological Actions : Antioxidants, Genoprotective

Problem Substances : Permethrin

Adverse Pharmacological Actions : Genotoxic, Oxidant

[+]

Olive leaf extract reduces oxidative stress and oxidative stress-related glucose metabolism disruption induced by 2.45 GHz Wi-Fi signals.Nov 01, 2013

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Pubmed Data : Environ Toxicol Pharmacol. 2013 Nov ;36(3):826-34. Epub 2013 Aug 3. PMID: 23994945

Article Published Date : Nov 01, 2013

Study Type : Animal Study

Olive oil has an inhibitory effect on fibrosis induced by carbon tetrachloride in rat liver.Feb 12, 2010

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Seabuckthorn pulp and seed oils protect against mouse intestinal injury from high-dose radiation by reducing cell apoptosis and inflammation.Dec 31, 2016

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Pubmed Data : Life Sci. 2019 Mar 1 ;220:136-146. Epub 2019 Jan 31. PMID: 30710640

Article Published Date : Feb 28, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Oleuropein

Diseases : Prostate Cancer

Pharmacological Actions : Antineoplastic Agents, Apoptotic

[+]

Sweet olive extract attenuates dextran sulfate sodium-induced colitis in mice.Aug 27, 2018

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Pubmed Data : J Med Food. 2018 Aug 28. Epub 2018 Aug 28. PMID: 30153075

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Pubmed Data : Int J Cancer. 2011 Apr 15 ;128(8):1955-65. PMID: 20568104

Article Published Date : Apr 14, 2011

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Chemotherapy-Induced Toxicity, Malignant Melanoma, Melanoma, Skin Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic

Additional Keywords : Natural Substance/Drug Antagonism, Natural Substance/Drug Synergy, Plant Leaves, Temozolomide

Problem Substances : Cisplatin, Doxorubicin, Paclitaxel

[+]

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2017 Mar 20 ;9(3). Epub 2017 Mar 20. PMID: 28335507

Article Published Date : Mar 19, 2017

Study Type : Review

Additional Links

Substances : Hydroxytyrosol

Diseases : Metabolic Syndrome X, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hypolipidemic

[+]

A review of medicinal herbs in the treatment of neuropathic pain.Mar 31, 2018

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Pubmed Data : Molecules. 2015 ;20(7):12992-3004. Epub 2015 Jul 17. PMID: 26193251

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Olive leaf extract

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Plant Extracts

[+]

An olive leaf extract rich in polyphenols promotes apoptosis in cervical cancer cells.Dec 31, 2018

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Pubmed Data : Nutr Cancer. 2019 ;71(2):320-333. Epub 2019 Jan 19. PMID: 30661406

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Pubmed Data : Infect Drug Resist. 2020 ;13:3501-3511. Epub 2020 Oct 8. PMID: 33116669

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Tyrosol

Diseases : Pseudomonas aeruginosa

Pharmacological Actions : Anti-Bacterial Agents, Quorum Sensing Inhibition

[+]

Bromelain and Olea europaea (L.) leaf extract mediated alleviation of benzo(a)pyrene induced lung cancer.Apr 22, 2021

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Pubmed Data : Environ Sci Pollut Res Int. 2021 Apr 23. Epub 2021 Apr 23. PMID: 33893581

Article Published Date : Apr 22, 2021

Study Type : In Vitro Study

Additional Links

Substances : Bromelain, Olive leaf extract

Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

Additional Keywords : Natural Substance Synergy

Problem Substances : Benzo(a)pyrene

[+]

Cancer glycolytic dependence as a new target of olive leaf extract.Jan 28, 2020

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Pubmed Data : Cancers (Basel). 2020 Jan 29 ;12(2). Epub 2020 Jan 29. PMID: 32013090

Article Published Date : Jan 28, 2020

Study Type : In Vitro Study

Additional Links

Substances : Olive leaf extract

Diseases : Breast Cancer, Cancers: All, Chronic Myeloid Leukemia, Colon Cancer, Melanoma

Pharmacological Actions : Antiproliferative , Chemotherapeutic

Additional Keywords : Cancer Glycolysis

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View the Evidence: 477 Abstracts with Olive Research

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The effects of olive leaf extract on cardiovascular risk factors in the general adult population.Oct 20, 2022

A combination of olive leaf and fruit extracts may be used efficiently and safely in reducing hypertension and MetS markers.Sep 14, 2020

A combination of garlic, mullein, calendula, st. johns wort and olive oil is as effective as an anesthetic drug for the management of acute otitis media-associated pain. Jul 01, 2001

A combination of hydroxytyrosol, omega-3 fatty acids and curcumin improves pain and inflammation among early stage breast cancer patients.Mar 31, 2019

A combination of red yeast rice and olive extract in high-risk hypercholesterolemic patients, without inducing new-onset SAMS.Nov 30, 2017

A Mediterranean diet (that emphasizes olive oil, fiber, fruits, vegetables, fish and alcohol and reduces meat/meat products) can be an effective measure for reducing the risk of myocardial infarction.Apr 01, 2005

A Mediterranean diet rich in olive oil may have a protective role in multiple sclerosis. Jun 01, 2009

A Mediterranean diet rich in virgin olive oil is associated with high plasma antioxidant capacity and reduced body weight gain.Dec 01, 2009

A mixture of honey, olive oil and beeswax is safe and effective for hemorrhoids and anal fissure.Feb 02, 2006

A mixture of natural honey, beeswax and olive oil appears useful in the management of dermatitis and psoriasis vulgaris.Dec 01, 2003

A nut-enriched diet has cholesterol-lowering properties, and olive oil has a cholesterol-lowering property independent of its fatty acid content. May 31, 2011

A red yeast rice-olive extract supplement reduces biomarkers of oxidative stress, OxLDL and Lp-PLA2, in subjects with metabolic syndrome.Jul 02, 2017

A standardized extract of Opuntia ficus-indica (L.) Mill and Olea europaea L. improves gastrointestinal discomfort.Mar 15, 2021

Adherence to a diet comprising mostly fruits, vegetables, fish, and olive/sunflower oil, along with avoidance of Western-type foods, may contribute to a substantial reduction in postmenopausal breast cancer risk.Nov 15, 2009

Adherence to a Mediterranean dietary pattern may protect against coronary artery wall production of inflammatory mediators in patients with unstable angina pectoris. Sep 01, 2005

Administration of olive oil followed by a low volume of polyethylene glycol-electrolyte lavage solution improves patient satisfaction with right-side colonic cleansing over conventional preparation. Sep 01, 2009

An onion-olive-oil combination reduces arterial blood pressure, plasma viscosity and hematocrit, indicating the cardiovascular benefits of a Mediterranean diet. Sep 01, 2000

Antioxidant activity of hydroxytyrosol and vitamin E reduces systemic inflammation in children with paediatric NAFLD.Oct 11, 2020

Chondroprotective properties of human-enriched serum following polyphenol extract absorption.Dec 15, 2019

Extra virgin olive oil mitigates postprandial lipopolysaccharide-induced inflammation and oxidative stress.Mar 01, 2019

Food fried in extra-virgin olive oil improves postprandial insulin response in obese, insulin-resistant women.Dec 13, 2010

Hibiscus sabdariffa and Olea europaea had comparable antihypertensive efficacy and safety to captopril in Egyptian patients with grade 1 hypertension.Jul 28, 2020

Hydroxytyrosol changed body composition parameters and modulated the antioxidant profile, the expression of inflammation and oxidative stress-related genes.Dec 31, 2016

Hydroxytyrosol is effective and safe in preventing recurrent candida episodes.Jun 30, 2020

Mediterranean diet enriched in extra-virgin olive oil or nuts modulates circulating exosomal non-coding RNAs.Nov 30, 2021

Mediterranean diets supplemented with olive oil or nuts have beneficial effects on cardiovascular risk factors.Jul 04, 2006

Mucosave formulation is an effective treatment for reducing the frequency and intensity of symptoms associated with gastroesophageal reflux.Dec 31, 2015

Naturopathic treatment for ear pain is demonstrated superior to antibiotic treatment.May 01, 2003

OLE prevents the loss of muscle mass associated with aging and exerts anti-inflammatory and insulin-sensitizing effects on adipose tissue and skeletal muscle.May 06, 2021

Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men.Dec 31, 2012

Olive (Olea europaea) leaf extract, at the dosage regimen of 500 mg twice daily, was similarly effective in lowering systolic and diastolic blood pressures in subjects with stage-1 hypertension as Captopril, given at its effective dose of 12.5-25 mg twiceFeb 14, 2011

Olive fruit and almond skin extract seems to protect LDL from oxidation and to prevent inflammatory status in moderately hypercholesterolemic subjects.Aug 17, 2020

Olive leaf extract can improve the clinical status of the patients and decrease the length of hospitalization.Oct 28, 2022

Olive leaf extract has a beneficial effects on upper respiratory illness in high school athletes. Feb 08, 2019

Olive leaf extract has calcium channel blocking activity consistent with its traditional role in the treatment of cardiovascular disease. Nov 20, 2008

Olive leaf tea is beneficial for lipid metabolism in adults with prediabetes.May 10, 2019

Olive oil consumption appears to reduce the risk of non-fatal heart attack in coronary disease. Apr 01, 2002

Olive oil consumption is associated with reduced incidence of ovarian cancer. Jun 01, 2002

Olive oil consumption reduces the susceptibility of LDL to oxidation, supporting the hypothesis that daily virgin olive oil intake protects cardiovascular health. Dec 01, 2007

Olive oil during pregnancy is associated with reduced wheezing during the first year of life of the offspring.Apr 01, 2010

Olive oil inhibits ageing signs induced by chronic stress.Mar 31, 2019

Olive polyphenols and bioavailable glutathione: Promising results in patients diagnosed with mild Alzheimer's disease.Dec 31, 2021

Omega-3 dietary supplementation may have a therapeutic effect in blepharitis and meibomian gland dysfunction.Jan 01, 2008

Oral supplement containing hydroxytyrosol and punicalagin improves dyslipidemia.Apr 28, 2022

Our results support the protective role of olive oil consumption on breast cancer among Canaries women.Feb 01, 2006

Supplementation with hydroxytyrosol and punicalagin improves early atherosclerosis markers.Mar 15, 2019

Supplementation with omega-3 fatty acids in pregnancy is associated with increased omega-3 fatty acids in breast milk and is positively associated with infant DHA status at 1 y.Dec 01, 2007

The combination of D-mannose, inulin, cranberry, bearberry, Olea europaea, Orthosiphon and Lactobacillus acidophilus SGL 11 per os represents a useful therapy for recurrent UTIs.Aug 31, 2020

The consumption of vegetables and fruits are inversely, significantly and strongly associated with breast cancer risk. There also is evidence that olive oil consumption may reduce the risk of breast cancer. Jan 18, 1995

The effect of dietary intervention with high-oleocanthal and oleacein olive oil in Patients with early-stage chronic lymphocytic leukemia.Dec 31, 2020

The efficacy of honey or olive oil on the severity of oral mucositis and pain compared.Dec 31, 2022

The results concluded that inflammation as a major cause of hypertension was significantly decreased in patients using olive leaf extract tablets.Dec 31, 2018

The topical application of a honey, olive oil and beeswax mixture has therapeutic effects in patients with Pityriasis Versicolor and Tinea. Mar 01, 2004

The topical application of honey, olive oil and beeswax has benefits in diaper dermatitis.Feb 01, 2005

These findings indicate that oleuropein improves postprandial glycaemic profile via hampering Nox2-derived oxidative stress.Mar 25, 2018

These new data support a potential role of oleuropein in the treatment of ulcerative colitis.Apr 14, 2017

Topical rosemary essential oil increased warmth perception in patients with systemic sclerosis-related Raynaud's phenomenon.Dec 31, 2021

Usefulness of extra virgin olive oil minor polar compounds in the management of chronic kidney disease patients.Feb 09, 2021

Vitamin E and hydroxytyrosol may be a promising strategy that could be easily diet integrated to improve NAFLD-related liver damage in children.Feb 10, 2019

5-Hydroxytyrosol inhibits HIV-1 replication in primary cells of the lower and upper female reproductive tract.Dec 31, 2016

Ethanol extract of olive leaf extract induced its genoprotective effect via the increase in the antioxidant capacity, inhibition of oxidative stress and scavenging of free radicals.Oct 01, 2011

Hydroxytyrosol as a promising ally in the treatment of fibromyalgia.Aug 08, 2020

OLE may promote the brown remodelling of white adipose tissue inducing thermogenesis and improving metabolic homeostasis.Dec 31, 2015

Oleuropein is effective in antimycoplasmal activity.Oct 01, 2002

Oleuropein might provide a basis for developing a new dietary strategy for the prevention and management of rheumatoid arthritis.Apr 19, 2017

Olive leaf extracts act as modulators of the human immune response.Nov 14, 2017

Combination treatment with hydroxytyrosol and vitamin E improves NAFLD-related fibrosis.Sep 13, 2022

Extra virgin olive oil inhibits Helicobacter pylori growth in vitro and the development of mice gastric mucosa lesions.Dec 31, 2021

Olive leaf extract inhibits metastatic melanoma spread through suppression of epithelial to mesenchymal transition.Sep 30, 2022

Effect of oleuropein on oxidative stress, inflammation and apoptosis induced by ischemia-reperfusion injury in rat kidney.Aug 14, 2020

Hydroxytyrosol ameliorates oxidative challenge and inflammatory response associated with lipopolysaccharide-mediated sepsis.Aug 24, 2020

Oleuropein can not only improve the inflammatory and oxidative indexes of castrated rats but also prevent osteoporosis.Dec 31, 2021

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View the Evidence:
477 Abstracts with Olive Research