Olive leaf extract

Name	AC	CK
Hypertension	7	46
Diabetes Mellitus: Type 2	4	16
Oxidative Stress	6	14
Cardiovascular Diseases	5	10
Cystitis	1	10
Dyslipidemias	1	10
Gastroesophageal Reflux	1	10
High Cholesterol	1	10
Inflammation	6	10
Insulin Resistance	1	10
Metabolic Syndrome X	1	10
Statin-Induced Pathologies	1	10
Upper Respiratory Infections	1	10
Urinary Tract Infections	1	10
Obesity	3	9
Chemically-Induced Liver Damage	4	8
DNA damage	3	8
Brain: Oxidative Stress	3	5
Colon Cancer	4	5
Atherosclerosis	3	4
Cancers: All	4	4
HIV Infections	4	4
Hypercholesterolemia	2	4
Lead Poisoning	2	4
Skin Cancer	2	4
Ultraviolet Radiation Induced Damage	3	4
Arteriosclerosis	2	3
Breast Cancer	2	3
Cadmium Poisoning	2	3
Glioblastoma	3	3
Kidney Damage	2	3
Melanoma	2	3
Myocardial Infarction	2	3
Skin Diseases: Photo-Aging	2	3
Alcohol Toxicity	1	2
Asthma	1	2
Autoimmune Diseases	1	2
Bisphenol-A Toxicity	1	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Toxicity	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Colitis	1	2
Colorectal Cancer	2	2
Diabetes Mellitus: Type 1	1	2
Dysbiosis	1	2
Fatty Liver	1	2
Gastritis	1	2
Gastrointestinal Inflammation	1	2
Gout	1	2
Hyperalgesia	1	2
Hyperglycemia	1	2
Hyperlipidemia	1	2
Hyperuricemia	1	2
Inflammatory Bowel Diseases	1	2
Kidney Damage: Chemically-Induced	1	2
Liver Damage: Drug-Induced	1	2
Malaria	1	2
Malignant Melanoma	1	2
Neurodegenerative Diseases	2	2
Neuropathic Pain	1	2
Opiate Tolerance	1	2
Osteoarthritis	1	2
Parkinson's Disease	1	2
Pesticide Toxicity: Permethrin	1	2
Prehypertension	1	2
Promyelocytic leukemia	2	2
Radiation Induced Illness	1	2
Sepsis	1	2
Staphylococcus aureus infection	2	2
Acquired Immunodeficiency Syndrome	1	1
Advanced Glycation End products (AGE)	1	1
Benzo[a]pyrene-induced Toxicity	1	1
Brain Inflammation	1	1
Campylobacter Infections	1	1
Cervical Cancer	1	1
Chronic Myeloid Leukemia	1	1
Clotting	1	1
Common Cold	1	1
Drug-Induced Toxicity: L-Thyroxine	1	1
Escherichia coli Infections	1	1
Fungus Diseases	1	1
Glioblastoma Multiforme	1	1
Gram-Positive Bacterial Infections	1	1
Helicobacter Pylori Infection	1	1
Herpes Simplex Virus Type 1	1	1
Infection: Antibiotic Resistant	1	1
Influenza	1	1
Leishmaniasis	1	1
Leukemia	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Liver Cancer	1	1
Liver Damage	1	1
Lung Cancer	1	1
Mesothelioma	1	1
Pancreatic Cancer	1	1
Pregnancy Complications	1	1
Prostate Cancer	1	1
Pseudomonas aeruginosa	1	1
Respiratory Tract Infections	1	1
Rhabdovirus Infections	1	1
Staphylococcal Infections	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Steptococcus Mutans Infections	1	1
Thrombosis	1	1

Name	AC	CK
Antioxidants	31	62
Anti-Inflammatory Agents	22	58
Hypolipidemic	5	29
Tumor Necrosis Factor (TNF) Alpha Inhibitor	8	22
Antihypertensive Agents	5	17
Hepatoprotective	9	17
Interleukin-6 Downregulation	3	14
Interleukin-8 downregulation	3	14
Gastrointestinal Agents	2	12
Antiproliferative	9	11
Renoprotective	6	11
Apoptotic	6	10
Calcium Channel Blockers	1	10
Hypotensive	1	10
Insulin Sensitizers	1	10
Interleukin-1 beta downregulation	6	10
Neuroprotective Agents	6	10
Chemotherapeutic	6	8
Genoprotective	3	8
Anti-Apoptotic	4	7
Cardioprotective	5	7
Immunomodulatory	3	7
Chemopreventive	5	6
Interferon-gamma (IFN-gamma) inducer	1	5
Chemoprotective Agents	2	4
Malondialdehyde Down-regulation	2	4
NF-kappaB Inhibitor	3	4
Superoxide Dismutase Up-regulation	2	4
Vasodilator Agents	2	4
Anti-Bacterial Agents	3	3
Anticholesteremic Agents	2	3
Antiviral Agents	3	3
Cell cycle arrest	2	3
Cyclooxygenase 2 Inhibitors	2	3
Cytoprotective	2	3
Analgesics	1	2
Anti-metastatic	2	2
Antimalarials	1	2
Antineoplastic Agents	1	2
Bax/Bcl2 Ratio: Decrease	1	2
Cardiovascular Agents	1	2
Caspase-3 Inhibition	1	2
Catalase Up-Regulation	1	2
Enzyme Inhibitors	1	2
Gastroprotective	1	2
Glucagon Like peptide 1 (GLP-1) Up-regulation	1	2
Glutathione Peroxidase 1 (GPx1) Up-Regulation	1	2
Glutathione Upregulation	1	2
Heme oxygenase-1 up-regulation	1	2
Nrf2 activation	1	2
Osteoprotective	1	2
Radioprotective	1	2
Xanthine oxidase inhibitor	1	2
Angiogenesis Inhibitors	1	1
Anti-Glycation Agents	1	1
Anti-HIV Agents	1	1
Anti-Platelet	1	1
Anti-Proliferative	1	1
Anti-atherogenic	1	1
Anticarcinogenic Agents	1	1
Antifungal Agents	1	1
Antimicrobial	1	1
Antimutagenic Agents	1	1
Cytotoxic	1	1
HIV Fusion Inhibitors	1	1
Hypoglycemic Agents	1	1
Interferon Gamma Reducer	1	1
Leishmanicidal	1	1
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1
MicroRNA modulator	1	1
Photoprotective	1	1
Quorum Sensing Inhibition	1	1
Scolicidal	1	1
Vascular Endothelial Growth Factor A Inhibitor	1	1
apoptosis	1	1

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Pubmed Data : J Food Biochem. 2022 Nov 2:e14494. Epub 2022 Nov 2. PMID: 36322398

Article Published Date : Nov 01, 2022

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Cardiac Hypertrophy, Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Cardioprotective

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Comparison of olive leaf, olive oil, palm oil, and omega-3 oil in acute kidney injury induced by sepsis.Dec 31, 2018

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Pubmed Data : Iran J Kidney Dis. 2012 Jan ;6(1):25-32. PMID: 22218116

Article Published Date : Jan 01, 2012

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Chemotherapy-Induced Toxicity: Gentamicin

Pharmacological Actions : Antioxidants, Glutathione Upregulation , Renoprotective

Problem Substances : Gentamicin

Adverse Pharmacological Actions : Nephrotoxic, Oxidant

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Olive leaf extract and glutamine significantly increase GLP-1 up-regulation. Sep 01, 2011

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Pubmed Data : Sci Pharm. 2011 Sep ;79(3):615-621. Epub 2011 Jun 9. PMID: 21886907

Article Published Date : Sep 01, 2011

Study Type : Animal Study

Additional Links

Substances : Glutamine, Olive leaf extract

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Glucagon Like peptide 1 (GLP-1) Up-regulation

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Olive leaf extract attenuates chlorpyrifos-induced neuro-and reproductive toxicity.Sep 26, 2022

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Pubmed Data : Life (Basel). 2022 Sep 27 ;12(10). Epub 2022 Sep 27. PMID: 36294935

Article Published Date : Sep 26, 2022

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Pesticide Toxicity

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Problem Substances : Chlorpyrifos

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Olive leaf extract can inhibit lead-induced brain injury by increasing antioxidant capacity and reducing apoptosis.Aug 04, 2013

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Pubmed Data : Neural Regen Res. 2013 Aug 5 ;8(22):2021-9. PMID: 25206510

Article Published Date : Aug 04, 2013

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Brain: Oxidative Stress, Lead Poisoning, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Catalase Up-Regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation

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Olive leaf extract is a promising chemotherapeutic agent for reducing the toxicity of carbendazim and possibly other pesticides and toxicants.Apr 01, 2011

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Pubmed Data : Eur Rev Med Pharmacol Sci. 2011 Apr ;15(4):413-26. PMID: 21608437

Article Published Date : Apr 01, 2011

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Therapeutic Actions : anti-cancer, anti-carcinogenic role

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Anti-cancer, Olive Leaf Extract, Phytotherapy, Plant Extracts

Problem Substances : Pesticides

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Olive leaf extract prevents spontaneous occurrence of non-alcoholic fatty liver in rats.Jan 01, 2010

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Pubmed Data : Pathology. 2010 Jan;42(1):66-72. PMID: 20025483

Article Published Date : Jan 01, 2010

Study Type : Animal Study

Additional Links

Substances : Oleuropein, Olive leaf extract

Diseases : Fatty Liver

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Olive leaf extract protect against L-arginine induced chronic pancreatitis.Jun 29, 2022

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Pubmed Data : Anat Cell Biol. 2022 Jun 30 ;55(2):205-216. PMID: 35773220

Article Published Date : Jun 29, 2022

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Pancreatitis: Chronic

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants

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Olive leaf extract protects against the genetic and oxidative damage by permethrin in vivo.Jan 20, 2012

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Pubmed Data : Cytotechnology. 2012 Jan 20. Epub 2012 Jan 20. PMID: 22262123

Article Published Date : Jan 20, 2012

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : DNA damage, Oxidative Stress, Pesticide Toxicity: Permethrin

Pharmacological Actions : Antioxidants, Genoprotective

Problem Substances : Permethrin

Adverse Pharmacological Actions : Genotoxic, Oxidant

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Olive leaf extract reduces oxidative stress and oxidative stress-related glucose metabolism disruption induced by 2.45 GHz Wi-Fi signals.Nov 01, 2013

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Pubmed Data : Environ Toxicol Pharmacol. 2013 Nov ;36(3):826-34. Epub 2013 Aug 3. PMID: 23994945

Article Published Date : Nov 01, 2013

Study Type : Animal Study

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Pubmed Data : Nutr Cancer. 2019 May 10:1-8. Epub 2019 May 10. PMID: 31074644

Article Published Date : May 09, 2019

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemopreventive

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Protective effects of olive leaf extract against reproductive toxicity of the lead acetate.Jul 02, 2021

Pharmacological Actions : Antiproliferative

Additional Keywords : Plant Extracts

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An olive leaf extract rich in polyphenols promotes apoptosis in cervical cancer cells.Dec 31, 2018

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Pubmed Data : Nutr Cancer. 2019 ;71(2):320-333. Epub 2019 Jan 19. PMID: 30661406

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Pubmed Data : Environ Sci Pollut Res Int. 2021 Apr 23. Epub 2021 Apr 23. PMID: 33893581

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Pubmed Data : Phytother Res. 2016 Mar ;30(3):503-9. Epub 2016 Jan 11. PMID: 26931616

Article Published Date : Feb 29, 2016

Study Type : In Vitro Study

Additional Links

Substances : Olive leaf extract

Diseases : Escherichia coli Infections, Staphylococcus aureus infection

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

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Olea europaea leaf extract improves the efficacy of temozolomide therapy in glioblastoma.Jul 31, 2017

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Pubmed Data : Biochem Biophys Res Commun. 2003 Aug 8;307(4):1029-37. PMID: 12878215

Article Published Date : Aug 08, 2003

Study Type : In Vitro Study

Additional Links

Substances : Olive leaf extract

Diseases : HIV Infections

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Olive leaf Extract suppresses inflammatory cytokine production and NLRP3 inflammasomes in human placenta.Apr 27, 2019

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Proliferation of hepatic and colon cancer cells, HepG2 and Caco-2, were shown to be sensitive to olive leaf extract. Mar 26, 2017

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Pubmed Data : Biomed Pharmacother. 2017 Mar 27 ;90:179-186. Epub 2017 Mar 27. PMID: 28360012

Article Published Date : Mar 26, 2017

Study Type : In Vitro Study

Additional Links

Substances : Olive leaf extract

Diseases : Colon Cancer, Colorectal Cancer, Liver Cancer

Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Plant Extracts

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Propolis and olive leaf extract alone and in combinations with acyclovir have antiviral efficacy against HSV-1.Dec 31, 2019

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Pubmed Data : Mikrobiyol Bul. 2020 Jan ;54(1):79-94. PMID: 32050880

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Bee Propolis, Olive leaf extract

Diseases : Herpes Simplex Virus Type 1

Pharmacological Actions : Antiviral Agents

Additional Keywords : Plant Extracts

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Protective effects of olive leaf extract on acrolein-exacerbated myocardial infarction.Feb 06, 2018

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Pubmed Data : Antioxidants (Basel). 2020 Feb 10 ;9(2). Epub 2020 Feb 10. PMID: 32050687

Article Published Date : Feb 09, 2020

Study Type : Review

Additional Links

Substances : Olive leaf extract

Diseases : Brain Inflammation , Cancers: All, Cardiovascular Diseases, Neurodegenerative Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Immunomodulatory, Neuroprotective Agents

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The total phenolic content and antioxidant activities of olive leaf extracts were determined.Jan 01, 2012

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View the Evidence: 139 Abstracts with Olive leaf extract Research

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The effects of olive leaf extract on cardiovascular risk factors in the general adult population.Oct 20, 2022

A combination of olive leaf and fruit extracts may be used efficiently and safely in reducing hypertension and MetS markers.Sep 14, 2020

A combination of red yeast rice and olive extract in high-risk hypercholesterolemic patients, without inducing new-onset SAMS.Nov 30, 2017

A red yeast rice-olive extract supplement reduces biomarkers of oxidative stress, OxLDL and Lp-PLA2, in subjects with metabolic syndrome.Jul 02, 2017

A standardized extract of Opuntia ficus-indica (L.) Mill and Olea europaea L. improves gastrointestinal discomfort.Mar 15, 2021

Chondroprotective properties of human-enriched serum following polyphenol extract absorption.Dec 15, 2019

OLE prevents the loss of muscle mass associated with aging and exerts anti-inflammatory and insulin-sensitizing effects on adipose tissue and skeletal muscle.May 06, 2021

Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men.Dec 31, 2012

Olive (Olea europaea) leaf extract, at the dosage regimen of 500 mg twice daily, was similarly effective in lowering systolic and diastolic blood pressures in subjects with stage-1 hypertension as Captopril, given at its effective dose of 12.5-25 mg twiceFeb 14, 2011

Olive leaf extract can improve the clinical status of the patients and decrease the length of hospitalization.Oct 28, 2022

Olive leaf extract has a beneficial effects on upper respiratory illness in high school athletes. Feb 08, 2019

Olive leaf extract has calcium channel blocking activity consistent with its traditional role in the treatment of cardiovascular disease. Nov 20, 2008

The combination of D-mannose, inulin, cranberry, bearberry, Olea europaea, Orthosiphon and Lactobacillus acidophilus SGL 11 per os represents a useful therapy for recurrent UTIs.Aug 31, 2020

The effect of dietary intervention with high-oleocanthal and oleacein olive oil in Patients with early-stage chronic lymphocytic leukemia.Dec 31, 2020

The results concluded that inflammation as a major cause of hypertension was significantly decreased in patients using olive leaf extract tablets.Dec 31, 2018

Ethanol extract of olive leaf extract induced its genoprotective effect via the increase in the antioxidant capacity, inhibition of oxidative stress and scavenging of free radicals.Oct 01, 2011

OLE may promote the brown remodelling of white adipose tissue inducing thermogenesis and improving metabolic homeostasis.Dec 31, 2015

Olive leaf extracts act as modulators of the human immune response.Nov 14, 2017

Extra virgin olive oil inhibits Helicobacter pylori growth in vitro and the development of mice gastric mucosa lesions.Dec 31, 2021

In vitro and in vivo assessment of the anti-inflammatory activity of olive leaf extract in rats.May 31, 2023

Olive leaf extract inhibits metastatic melanoma spread through suppression of epithelial to mesenchymal transition.Sep 30, 2022

Olive leaves extract and oleuropein improve insulin sensitivity.Dec 31, 2022

Administration of olive leaf and hydroxytyrosol extracts significantly improved the antioxidant state in asthma disease.Oct 22, 2019

An oleuropein-enriched olive leaf extract exerted antihypertensive effects on genetic hypertension related to the improvement of vascular function.Nov 22, 2015

Antidiabetic effect of olive leaf extract on streptozotocin-induced diabetes mellitus.Sep 21, 2020

Antidiabetic potential and antioxidant activity of Olea europaea extracts.Dec 31, 2021

Antioxidant and anti-inflammatory effect of olive leaf extract treatment in diabetic rat brain.Jun 16, 2021

Bone-marrow-derived mesenchymal stem cells, their conditioned media, and olive leaf extract protect against cisplatin-induced toxicity.Sep 05, 2022

Cardiac hypertrophy and fibrosis were attenuated by olive leaf extract treatment in a rat model of diabetes.Nov 01, 2022

Comparison of olive leaf, olive oil, palm oil, and omega-3 oil in acute kidney injury induced by sepsis.Dec 31, 2018

Consumption of citrus fruit and olive leaf extract have beneficial effects on lipid metabolism.Sep 25, 2017

Dried leaf extract of Olea europaea ameliorates islet-directed autoimmunity in mice.Dec 22, 2009

Effect of the olive leaf extract in chronic spinal cord injury model.Feb 28, 2023

Evaluation of the anti-malarial activity of crude extract and solvent fractions of the leaves of Olea europaea.Jul 10, 2019

Evaluation of the protective effect of olive leaf extract on cisplatin-induced testicular damage.Dec 31, 2017

Hibiscus sabdariffa and Olive leaf extracts could be useful in the treatment of preclinical hypertension.Apr 30, 2016

Higher concentrations of Olive leaf extract significantly decreased mitochondrial membrane potential, respiratory control ratio, and ADP/O. Sep 01, 2011

Hydroxytyrosol and olive leaf extract exert cardioprotective effects by inhibiting GRP78 and CHOP expression.Dec 31, 2016

Immunomodulatory properties of Olea europaea leaf extract in intestinal inflammation.Sep 30, 2017

O. europaea leaves could be used for the management of hypercholesterolemia and atherosclerosis.Oct 03, 2018

OEE and HSE exerted negative inotropic and vasorelaxant effects without any chronotropic property with higher cytoprotective effects and antioxidant activities.Dec 31, 2014

Olea europaea leaf extract ameliorates learning and memory deficits in streptozotocin-induced diabetic rats.Feb 28, 2022

Oleuropein could be used in the prevention of cadmium hepatotoxicity.Dec 31, 2019

Oleuropein-rich olive leaf extract attenuates neuroinflammation in the Alzheimer's disease model.Mar 08, 2022

Olive leaf attenuates early diabetic neuropathic pain through prevention of high glucose-induced cell damage. Apr 22, 2011

Olive leaf contains phenolics with radioprotective properties. Jan 01, 1994

Olive leaf extract ameliorates gentamicin nephrotoxicity via antioxidant activity, increase of renal glutathione content, and increase of renal antioxidant enzymes activity, except for glutathione peroxidase.Jan 01, 2012

Olive leaf extract and glutamine significantly increase GLP-1 up-regulation. Sep 01, 2011

Olive leaf extract attenuates chlorpyrifos-induced neuro-and reproductive toxicity.Sep 26, 2022

Olive leaf extract can inhibit lead-induced brain injury by increasing antioxidant capacity and reducing apoptosis.Aug 04, 2013

Olive leaf extract exerts beneficial effects in high fat diet-induced obesity.Oct 10, 2019

Olive leaf extract has a potential antitolerant property against the chronic usage of morphine and that its main component, oleuropein, is responsible for such effect.Mar 15, 2012

Olive leaf extract has xanthine-oxidase inhibiting activity which confirms its traditional use for gout. May 14, 2011

Olive leaf extract in a dose-dependent manner ameliorates cardiac damage in diabetic cardiomyopathy.May 09, 2022

Olive leaf extract influences liver microsomal detoxifying enzymes in rats orally exposed to 2-amino-l-methyI-6-phenyI-imidazo pyridine.Sep 30, 2022

Olive leaf extract is a promising chemotherapeutic agent for reducing the toxicity of carbendazim and possibly other pesticides and toxicants.Apr 01, 2011

Olive leaf extract is superior to the drug glibenclamide in significantly reversing the symptoms of diabetes in type 2 diabetic rats. Oct 01, 2007

Olive leaf extract modulates glycerol-induced kidney and liver damage.Apr 14, 2020

Olive leaf extract prevents cartilage degeneration in osteoarthritis.Mar 26, 2018

Olive leaf extract prevents chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice. Nov 01, 2009

Olive leaf extract prevents obesity development by regulating the expression of molecules involved in adipogenesis and thermogenesis.Apr 30, 2019

Olive leaf extract prevents obesity, cognitive decline, and depression and improves exercise capacity in mice.Jun 13, 2021

Olive leaf extract prevents spontaneous occurrence of non-alcoholic fatty liver in rats.Jan 01, 2010

Olive leaf extract protect against L-arginine induced chronic pancreatitis.Jun 29, 2022

Olive leaf extract protects against the genetic and oxidative damage by permethrin in vivo.Jan 20, 2012

Olive leaf extract reduces oxidative stress and oxidative stress-related glucose metabolism disruption induced by 2.45 GHz Wi-Fi signals.Nov 01, 2013

Olive leaf extract suppresses atherosclerosis through the inhibition of inflammation. Aug 01, 2008

Olive leaf extract treatment may be effective in decreasing DOX-induced cardiac, hepatic and renal oxidative stress and injury.May 31, 2015

Olive leaf extract was effective in reducing hepatic damage caused by carbon tetrachloride.Mar 19, 2018

Olive leaf methanolic extract prevents ethanol-induced gastritis.Jun 30, 2017

Olive leaves extract might be useful for preventing the death of dopaminergic neurons in patients with Parkinson's disease.Jan 31, 2018

Olive oil and leaf extract could protect against ﬂuoxetine-induced liver injury.Dec 22, 2017

Olive leaf extract

View the Evidence:
139 Abstracts with Olive leaf extract Research