Orange

Name	AC	CK
Oxidative Stress	9	56
Inflammation	8	47
Cardiovascular Diseases	3	30
Lipid Peroxidation	3	22
Anxiety Disorders	2	20
Hormone Imbalances: Low Melatonin	2	20
Hypertension	2	20
Mood Disorders	2	20
Aging	2	12
Cancers: All	3	12
Cognitive Decline/Dysfunction	2	12
Obesity	2	12
Birth: Labor & Delivery	1	10
C-Reactive Protein	1	10
Cervical Dysplasia	1	10
Cholesterol: Oxidation	1	10
DNA damage	1	10
Diabetes Mellitus: Type 2	1	10
Elevated CRP	1	10
Endothelial Dysfunction	1	10
Esophageal Cancer	1	10
Fatigue	1	10
Fibrinogen: Elevated	1	10
HDL: Low	1	10
Hemodialysis	1	10
Hepatitis C	1	10
High Fat Diet	1	10
Hydrogen Peroxide Induced Toxicity	1	10
Kidney Stones	1	10
Macular Degeneration	1	10
Nonalcoholic fatty liver disease (NAFLD)	1	10
Osteoarthritis: Knee	1	10
Peripheral Arterial Disease	1	10
Prehypertension	1	10
Sleep Disorders	1	10
Stroke	1	10
Triglycerides: Elevated	1	10
Breast Cancer	2	3
Colon Cancer	2	3
Gastric Ulcer	2	3
Osteoarthritis	2	3
Adenomatous Polyposis Coli	1	2
Alcohol Toxicity	1	2
Arthritis	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Depression	1	2
Diabetic Nephropathy	1	2
Endotoxemia	1	2
Erectile Dysfunction	1	2
Hyperthyroidism	1	2
Hyperuricemia	1	2
Inflammatory Bowel Diseases	1	2
Intestinal Cancer	1	2
Intestinal Polyps	1	2
Kidney Damage: Chemically-Induced	1	2
Lung Cancer	2	2
Metabolic Syndrome X	1	2
Osteoporosis	1	2
Osteoporosis: Male	1	2
Promyelocytic leukemia	2	2
Aspergillosis	1	1
Cancers: Multi-Drug Resistant	1	1
Candida Albicans	1	1
Colorectal Cancer	1	1
Diabetes: Oxidative Stress	1	1
Dysbiosis	1	1
Helicobacter Pylori Infection	1	1
Leishmaniasis	1	1
Leukemia: T-cell acute Lymphoblastic	1	1
Premenstrual syndrome	1	1
Prostate Cancer	1	1
Prostatic Hyperplasia: Benign	1	1
Pseudomonas aeruginosa	1	1
Skin Diseases: Photo-Aging	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Sunburn	1	1

Name	AC	CK
Antioxidants	17	94
Anti-Inflammatory Agents	9	57
Malondialdehyde Down-regulation	3	22
Gastrointestinal Agents	2	12
Anti-Anxiety Agents	1	10
Anticholesteremic Agents	1	10
Antihypertensive Agents	1	10
Hypoglycemic Agents	1	10
Hypolipidemic	1	10
Insulin Sensitizers	1	10
Sedative effects	1	10
Uricosuric Agents	1	10
Antiproliferative	9	9
Apoptotic	7	9
Tumor Necrosis Factor (TNF) Alpha Inhibitor	4	8
Anticarcinogenic Agents	5	7
Chemopreventive	3	5
Interleukin-1 beta downregulation	2	4
Renoprotective	2	4
Anti-Bacterial Agents	3	3
Anti-Apoptotic	1	2
Anti-Fibrotic	1	2
Anti-Ulcer Agents	1	2
Antidepressive Agents	1	2
Antineoplastic Agents	1	2
Chemoprotective Agents	1	2
Cyclooxygenase 2 Inhibitors	1	2
Hepatoprotective	1	2
Interleukin-6 Downregulation	1	2
Matrix metalloproteinase-2 (MMP-2) inhibitor	1	2
Neuroprotective Agents	1	2
Superoxide Dismutase Up-regulation	1	2
Anti-metastatic	1	1
Antimicrobial	1	1
Cell cycle arrest	1	1
Chemosensitizer	1	1
Gastroprotective	1	1
Leishmanicidal	1	1
Nitric Oxide Inhibitor	1	1
Proteasome Inhibitors	1	1

[+]

This meta-analysis demonstrates the beneficial effects of chronic orange juice consumption on blood pressure and HDL-C in overweight and obese adults.Nov 27, 2022

Click here to read the entire abstract

Pubmed Data : Food Funct. 2022 Nov 28 ;13(23):11945-11953. Epub 2022 Nov 28. PMID: 36383179

Article Published Date : Nov 27, 2022

Study Type : Meta Analysis

Additional Links

Substances : Orange

Diseases : Hypertension, Obesity, Overweight

Pharmacological Actions : Antihypertensive Agents, Cardioprotective

[+]

Ambient odor of orange in a dental office reduces anxiety and improves mood in female patients.Dec 13, 1901

Click here to read the entire abstract

Pubmed Data : Physiol Behav. 2000 Oct 1-15;71(1-2):83-6. PMID: 11134689

Study Type : Human Study

Additional Links

Substances : Orange

Diseases : Anxiety Disorders, Mood Disorders

Therapeutic Actions : Aromatherapy

[+]

Ambient odors of orange and lavender reduce anxiety and improve mood in a dental office.Sep 15, 2005

Click here to read the entire abstract

Pubmed Data : Physiol Behav. 2005 Sep 15;86(1-2):92-5. PMID: 16095639

Article Published Date : Sep 15, 2005

Study Type : Human Study

Additional Links

Substances : Lavender, Orange

Diseases : Anxiety Disorders, Mood Disorders

Therapeutic Actions : Aromatherapy

[+]

Antioxidant efficacy of a standardized red orange extract in elderly subjects.Oct 10, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Oct 11 ;14(20). Epub 2022 Oct 11. PMID: 36296919

Article Published Date : Oct 10, 2022

Study Type : Human Study

Additional Links

Substances : Orange

Diseases : Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Aroma-massage therapy with ginger and orange oil have potential as an alternative method for short-term knee pain relief.May 01, 2006

Click here to read the entire abstract

Pubmed Data : Microbes Infect. 2006 May;8(6):1450-4. Epub 2006 Mar 29. PMID: 18534325

Article Published Date : May 01, 2006

Study Type : Human Study

Additional Links

Substances : Ginger, Orange

Diseases : Osteoarthritis: Knee

Therapeutic Actions : Aromatherapy , Massage/Therapeutic Touch

[+]

Aromatherapy blend of thyme, orange, clove bud, and frankincense boosts energy levels in post-COVID-19 female patients.Mar 23, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Complement Ther Med. 2022 Mar 24:102823. Epub 2022 Mar 24. PMID: 35341944

Article Published Date : Mar 23, 2022

Study Type : Human Study

Additional Links

Substances : Clove, Frankincense, Orange, Thyme

Diseases : Coronavirus Infection, Fatigue

Therapeutic Actions : Aromatherapy

[+]

Aromatherapy is a noninvasive and effective method to help women overcome their anxiety during labor.Oct 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Nurs Midwifery Res. 2015 Nov-Dec;20(6):661-4. PMID: 26793249

Article Published Date : Oct 31, 2015

Study Type : Human Study

Additional Links

Substances : Orange

Diseases : Birth: Labor & Delivery

Therapeutic Actions : Aromatherapy

Pharmacological Actions : Anti-Anxiety Agents

Additional Keywords : Essential Oils

[+]

Blood orange juice intake modulates plasma and PBMC microRNA expression in overweight and insulin resistance women.Nov 24, 2022

Click here to read the entire abstract

Pubmed Data : J Nutr Biochem. 2022 Nov 25:109240. Epub 2022 Nov 25. PMID: 36442716

Article Published Date : Nov 24, 2022

Study Type : Human Study

Additional Links

Substances : Orange

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, MicroRNA modulator, NF-kappaB Inhibitor

[+]

Chronic daily consumption of flavanone-rich 100% orange juice over 8 week was beneficial for cognitive function in healthy older adults.Feb 28, 2015

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 2015 Mar ;101(3):506-14. Epub 2015 Jan 14. PMID: 25733635

Article Published Date : Feb 28, 2015

Study Type : Human Study

Additional Links

Substances : Orange

Diseases : Cognitive Decline/Dysfunction

Additional Keywords : Fruit Juice

[+]

Common fruit provide a dietary source of melatonin.Jan 16, 2013

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2013 Jan 17. Epub 2013 Jan 17. PMID: 23252791

Article Published Date : Jan 16, 2013

Study Type : Human Study

Additional Links

Substances : Banana, Orange, Pineapple

Diseases : Hormone Imbalances: Low Melatonin

[+]

Comparing effects of aromatherapy with lavender essential oil and orange essential oil on fatigue of hemodialysis patients.Jul 31, 2019

Click here to read the entire abstract

Pubmed Data : Complement Ther Clin Pract. 2019 Aug ;36:64-68. Epub 2019 May 29. PMID: 31383445

Article Published Date : Jul 31, 2019

Study Type : Human Study

Additional Links

Substances : Lavender: Essential Oil, Orange

Diseases : Fatigue, Hemodialysis

Therapeutic Actions : Aromatherapy

Additional Keywords : Essential Oils

[+]

Consumption of fruits that are high in antioxidants could represent a useful means to improve the antioxidant status of NAFLD.Jul 13, 2016

Click here to read the entire abstract

Pubmed Data : Int J Vitam Nutr Res. 2016 Jul 14:1-7. Epub 2016 Jul 14. PMID: 27414418

Article Published Date : Jul 13, 2016

Study Type : Human Study

Additional Links

Substances : Orange, Pomegranate

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation

[+]

Consumption of orange fermented beverage improves antioxidant status and reduces peroxidation lipid and inflammatory markers.Apr 30, 2018

Click here to read the entire abstract

Pubmed Data : J Sci Food Agric. 2018 May ;98(7):2777-2786. Epub 2017 Nov 28. PMID: 29124773

Article Published Date : Apr 30, 2018

Study Type : Human Study

Additional Links

Substances : Fermented Foods and Beverages, Orange

Diseases : C-Reactive Protein, Cholesterol: Oxidation, Inflammation, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Uricosuric Agents

[+]

Dietary consumption of fruits high in antioxidant nutrients reduce the risk of incident cervical intraepithelial neoplasia.Sep 01, 2010

Click here to read the entire abstract

Pubmed Data : Gynecol Oncol. 2010 Sep;118(3):289-94. Epub 2010 Jun 18. PMID: 20691333

Article Published Date : Sep 01, 2010

Study Type : Human Study

Additional Links

Substances : Alpha-Carotene, Cryptoxanthin, Fruit: All, Orange, Papaya

Diseases : Cervical Dysplasia

Pharmacological Actions : Antioxidants

[+]

Dietary flavonoid intake at midlife and healthy aging in women.Nov 30, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Clin Nutr. 2014 Dec ;100(6):1489-97. Epub 2014 Oct 29. PMID: 25411284

Article Published Date : Nov 30, 2014

Study Type : Human Study

Additional Links

Substances : Apple, Berries: All, Flavonoids, Onion, Orange

Diseases : Aging, Cancers: All, Cardiovascular Diseases, Diabetes Mellitus: Type 2, Hypertension, Stroke

Additional Keywords : Risk Reduction

[+]

Effect of the consumption of hesperidin in orange juice on the transcriptomic profile of subjects with elevated blood pressure.Nov 30, 2021

Click here to read the entire abstract

Pubmed Data : Clin Nutr. 2021 Dec ;40(12):5812-5822. Epub 2021 Oct 21. PMID: 34800819

Article Published Date : Nov 30, 2021

Study Type : Human Study

Additional Links

Substances : Hesperidin, Orange

Diseases : Hypertension

Pharmacological Actions : Anti-Inflammatory Agents, Insulin Sensitizers

[+]

Effects of blood orange juice intake on antioxidant bioavailability and on different markers related to oxidative stress.Feb 22, 2005

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2005 Feb 23 ;53(4):941-7. PMID: 15713002

Article Published Date : Feb 22, 2005

Study Type : Human Study

Additional Links

Substances : Orange

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation

[+]

Effects of tangerine essential oil on brain waves, moods, and sleep onset latency.Oct 20, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2020 Oct 21 ;25(20). Epub 2020 Oct 21. PMID: 33096890

Article Published Date : Oct 20, 2020

Study Type : Human Study

Additional Links

Substances : Orange

Diseases : Sleep Disorders

Pharmacological Actions : Sedative effects

Additional Keywords : Essential Oils

[+]

Flavanone intake is inversely associated with esophageal cancer risk and may account, with vitamin C, for the protective effect of fruit, especially citrus fruit, on esophageal cancer. Apr 10, 2000

Click here to read the entire abstract

Pubmed Data : Arch Intern Med. 2000 Apr 10;160(7):1009-13. PMID: 17192901

Article Published Date : Apr 10, 2000

Study Type : Human Study

Additional Links

Substances : Flavonoids, Fruit: All, Grapefruit, Lemon Juice, Orange, Vitamin C

Diseases : Esophageal Cancer

Additional Keywords : Risk Reduction

[+]

Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans.Nov 30, 2016

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2016 Dec ;116(12):1999-2010. Epub 2017 Jan 9. PMID: 28065188

Article Published Date : Nov 30, 2016

Study Type : Human Study

Additional Links

Substances : Orange

Diseases : Cardiovascular Diseases, Endothelial Dysfunction

Additional Keywords : Citrus Juice

[+]

Flavonoid-rich orange juice intake and altered gut microbiome in young adults with depressive symptoms.Jun 17, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2020 Jun 18 ;12(6). Epub 2020 Jun 18. PMID: 32570775

Article Published Date : Jun 17, 2020

Study Type : Human Study

Additional Links

Substances : Flavonoids, Orange

Diseases : Depression

Pharmacological Actions : Antidepressive Agents, Gastrointestinal Agents

[+]

Hesperidin-enriched orange juice could be a useful co-adjuvant tool for BP and pulse pressures management in pre- and stage-1 hypertensive individuals.Jul 12, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur J Nutr. 2020 Jul 13. Epub 2020 Jul 13. PMID: 32661681

Article Published Date : Jul 12, 2020

Study Type : Human Study

Additional Links

Substances : Hesperidin, Orange

Diseases : Hypertension, Prehypertension

Pharmacological Actions : Antihypertensive Agents

[+]

In healthy subjects the concomitant intake of orange juice may prevent the low-grade inflammatory reaction induced by a fatty meal.Jan 31, 2015

Click here to read the entire abstract

Pubmed Data : Thromb Res. 2015 Feb ;135(2):255-9. Epub 2014 Dec 13. PMID: 25550188

Article Published Date : Jan 31, 2015

Study Type : Human Study

Additional Links

Substances : Orange

Diseases : High Fat Diet, Inflammation, Triglycerides: Elevated

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Orange juice consumption is associated with better diet quality, improved nutrient adequacy and a decreased risk for obesity.Dec 11, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutr J. 2012 Dec 12 ;11:107. Epub 2012 Dec 12. PMID: 23234248

Article Published Date : Dec 11, 2012

Study Type : Human Study

Additional Links

Substances : Orange

Diseases : Cardiovascular Diseases, Obesity

Additional Keywords : Anti-Obesity Agents, Risk Reduction

[+]

Orange juice ingestion and supplemental vitamin C are equally effective at reducing plasma lipid peroxidation.Nov 30, 2003

Click here to read the entire abstract

Pubmed Data : J Am Coll Nutr. 2003 Dec ;22(6):519-23. PMID: 14684757

Article Published Date : Nov 30, 2003

Study Type : Human Study

Additional Links

Substances : Orange, Vitamin C

Diseases : Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Orange juice intake improved depressive symptoms in young adults with major depressive disorder.Dec 27, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Dec 28 ;15(1). Epub 2022 Dec 28. PMID: 36615801

Article Published Date : Dec 27, 2022

Study Type : Human Study

Additional Links

Substances : Flavonoids, Orange

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

[+]

Orange juice may have a therapeutic effect in reducing stone-forming risk. Nov 01, 2006

Click here to read the entire abstract

Pubmed Data : Clin J Am Soc Nephrol. 2006 Nov;1(6):1269-74. Epub 2006 Aug 30. PMID: 17699358

Article Published Date : Nov 01, 2006

Study Type : Human Study

Additional Links

Substances : Orange

Diseases : Kidney Stones

[+]

Orange juice raises HDL cholesterol in subjects with high cholesterol. Nov 01, 2000

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 2000 Nov;72(5):1095-100. PMID: 11063434

Article Published Date : Nov 01, 2000

Study Type : Human Study

Additional Links

Substances : Orange

Diseases : HDL: Low

[+]

Orange juice vs vitamin C: effect on hydrogen peroxide-induced DNA damage in mononuclear blood cells.Mar 31, 2007

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Br J Nutr. 2007 Apr ;97(4):639-43. PMID: 17349075

Article Published Date : Mar 31, 2007

Study Type : Human Study

Additional Links

Substances : Orange, Vitamin C

Diseases : DNA damage, Hydrogen Peroxide Induced Toxicity, Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Orange juice was a convenient food in the diet of patients due to the increase in antioxidant capacity and decreased inflammation and cholesterol.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Food Nutr Res. 2017 ;61(1):1296675. Epub 2017 Mar 22. PMID: 28469541

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Substances : Orange

Diseases : Hepatitis C

Pharmacological Actions : Anti-Inflammatory Agents, Anticholesteremic Agents, Antioxidants

[+]

Photoprotective and antiaging effects of a standardized red orange.May 26, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 May 27 ;14(11). Epub 2022 May 27. PMID: 35684041

Article Published Date : May 26, 2022

Study Type : Human Study

Additional Links

Substances : Orange

Diseases : Aging, Ultraviolet Radiation Induced Damage

Therapeutic Actions : Sunlight exposure

Pharmacological Actions : Antioxidants, Photoprotective

Additional Keywords : Plant Extracts

[+]

Supplementation with orange and blackcurrant juice improves inflammatory markers in patients with peripheral arterial disease. Jan 01, 2009

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2009 Jan;101(2):263-9. Epub 2008 May 28. PMID: 18507878

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Substances : Black Currant, Orange, Sweet Orange

Diseases : Elevated CRP, Fibrinogen: Elevated, Inflammation, Peripheral Arterial Disease

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Oranges are Anti-inflammatory

[+]

The consumption of an orange juice with a high content of flavanones improved oxidative stress and inflammatory biomarkers.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Mol Nutr Food Res. 2017 02 ;61(2). Epub 2016 Dec 9. PMID: 27689343

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Substances : Orange

Diseases : Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

The effect of a citrus and pomegranate complex on physical fitness and mental well-being in healthy elderly.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Nutr Health Aging. 2022 ;26(9):839-846. PMID: 36156675

Article Published Date : Dec 31, 2021

Study Type : Human Study

Additional Links

Substances : Flavonoids, Grapefruit, Lemon, Orange, Pomegranate

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation

[+]

The oral supplement assessed in this study safely and effectively promotes significant hair growth in women with temporary hair thinning.Oct 31, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Aesthet Dermatol. 2012 Nov ;5(11):28-34. PMID: 23198010

Article Published Date : Oct 31, 2012

Study Type : Human Study

Additional Links

Substances : Cherry: All Varieties, Orange, Silica

Diseases : Hair Loss

Additional Keywords : Hair Regeneration

[+]

These findings suggest a protective association between dietary intake of flavonoids and the likelihood of having age-related macular degeneration.Jul 05, 2018

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 2018 Jul 6. Epub 2018 Jul 6. PMID: 29982448

Article Published Date : Jul 05, 2018

Study Type : Human Study

Additional Links

Substances : Flavonoids, Orange

Diseases : Macular Degeneration

Additional Keywords : Risk Reduction

[+]

These results suggested that a daily consumption of orange had a positive effect on the intestinal microbiota and metabolic biomarkers of young women.Jan 31, 2019

Click here to read the entire abstract

Pubmed Data : J Med Food. 2019 Feb ;22(2):202-210. Epub 2019 Jan 14. PMID: 30638420

Article Published Date : Jan 31, 2019

Study Type : Human Study

Additional Links

Substances : Orange

Pharmacological Actions : Gastrointestinal Agents, Hypoglycemic Agents, Hypolipidemic, Insulin Sensitizers

Additional Keywords : Microbiota

[+]

Tropical fruit consumption increases the serum melatonin concentrations and also raises the antioxidant capacity in the serum of healthy volunteers in proportion to serum melatonin levels.Oct 04, 2012

Click here to read the entire abstract

Pubmed Data : J Pineal Res. 2012 Oct 5. Epub 2012 Oct 5. PMID: 23137025

Article Published Date : Oct 04, 2012

Study Type : Human Study

Additional Links

Substances : Banana, Orange, Pineapple

Diseases : Hormone Imbalances: Low Melatonin

[+]

Anti-inflammatory effect of a flavonoid-rich extract of orange juice in adult zebrafish subjected to Vibrio anguillarum-induced enteritis.Apr 26, 2020

Click here to read the entire abstract

Pubmed Data : Nat Prod Res. 2020 Apr 27:1-4. Epub 2020 Apr 27. PMID: 32338069

Article Published Date : Apr 26, 2020

Study Type : Animal Study

Additional Links

Substances : Orange

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

A standardized extract prepared from red orange and lemon wastes blocks high-fat diet-induced hyperglycemia and hyperlipidemia.Jul 14, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2021 Jul 15 ;26(14). Epub 2021 Jul 15. PMID: 34299566

Article Published Date : Jul 14, 2021

Study Type : Animal Study

Additional Links

Substances : Lemon, Orange

Diseases : High Fat Diet, Hyperglycemia, Hyperlipidemia

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic

[+]

A variety of orange by-products could be used as food supplements in the potential amelioration of inflammatory bowel diseases.Sep 18, 2018

Click here to read the entire abstract

Pubmed Data : Food Funct. 2018 Sep 19 ;9(9):4888-4896. PMID: 30167607

Article Published Date : Sep 18, 2018

Study Type : Animal Study

Additional Links

Substances : Orange

Diseases : Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Ameliorating effect of Citrus trifoliata L. fruits extract on motor incoordination, neurodegeneration and oxidative stress in Parkinson's disease model.Sep 01, 2023

Click here to read the entire abstract

Pubmed Data : Nutr Neurosci. 2023 Sep 2:1-13. Epub 2023 Sep 2. PMID: 37658797

Article Published Date : Sep 01, 2023

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Orange

Diseases : Parkinson's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents

[+]

Antidepressant-like effect of Citrus sinensis essential oil and its main component limoneneApr 01, 2019

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2019 Apr 2. Epub 2019 Apr 2. PMID: 30905156

Article Published Date : Apr 01, 2019

Study Type : Animal Study

Additional Links

Substances : D-Limonene, Orange

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

[+]

Blood orange juice intake changes specific bacteria of gut microbiota associated with cardiometabolic biomarkers.Dec 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Microbiol. 2023 ;14:1199383. Epub 2023 Jul 4. PMID: 37469434

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Orange

Diseases : Metabolic Diseases

Pharmacological Actions : Gastrointestinal Agents

[+]

Citrus juice positively affects serum antioxidant status and bone strength.May 01, 2006

Click here to read the entire abstract

Pubmed Data : Nutrition. 2006 May;22(5):559-63. Epub 2006 Feb 10. PMID: 16472977

Article Published Date : May 01, 2006

Study Type : Animal Study

Additional Links

Substances : Orange

Diseases : Osteoporosis

Pharmacological Actions : Antioxidants

[+]

Effects of Moro orange juice on some metabolic and morphological parameters in obese and diabetes.Aug 05, 2020

Click here to read the entire abstract

Pubmed Data : J Sci Food Agric. 2020 Aug 6. Epub 2020 Aug 6. PMID: 32767388

Article Published Date : Aug 05, 2020

Study Type : Animal Study

Additional Links

Substances : Orange

Diseases : Metabolic Syndrome X, Obesity

Additional Keywords : Anti-Obesity Agents

[+]

Effects of orange essential oil on intestinal microflora in mice.Feb 05, 2019

Click here to read the entire abstract

Pubmed Data : J Sci Food Agric. 2019 Feb 6. Epub 2019 Feb 6. PMID: 30729524

Article Published Date : Feb 05, 2019

Study Type : Animal Study

Additional Links

Substances : Orange

Pharmacological Actions : Gastrointestinal Agents

[+]

Enriching orange with leaf and stem juice results in a functional and nutritious beverage that protects against obesity and its associated health issues.Feb 24, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2022 Feb 25 ;11(3). Epub 2022 Feb 25. PMID: 35326107

Article Published Date : Feb 24, 2022

Study Type : Animal Study

Additional Links

Substances : Beet, Orange

Diseases : High Fat Diet, Hyperlipidemia, Obesity, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Hypolipidemic

Additional Keywords : Anti-Obesity Agents

[+]

Flavonoids bergamot and orange juices may be of use in preventing oxidative cell injury and pave the way for further research into a novel healthy approach to avoid lung disorders.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:957031. Epub 2015 Jun 21. PMID: 26221182

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Bergamot orange, Orange

Diseases : Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Inhibition of azoxymethane-induced colon cancer by orange juice.Dec 31, 1999

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2000 ;36(2):224-9. PMID: 10890034

Article Published Date : Dec 31, 1999

Study Type : Animal Study

Additional Links

Substances : Orange

Diseases : Colon Cancer

Pharmacological Actions : Antineoplastic Agents, Chemopreventive

Additional Keywords : Fruit Juice, Phytotherapy

[+]

Orange fruit peel extract attenuates chemotherapy-induced toxicity.Oct 03, 2021

Click here to read the entire abstract

Pubmed Data : Food Funct. 2021 Oct 4 ;12(19):9443-9455. Epub 2021 Oct 4. PMID: 34606555

Article Published Date : Oct 03, 2021

Study Type : Animal Study

Additional Links

Substances : Citrus Peel , Orange

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Orange juice and hesperetin supplementation have significant therapeutic activity in hyperuricemic rats. Nov 01, 2009

Click here to read the entire abstract

Pubmed Data : J Clin Biochem Nutr. 2009 Nov;45(3):285-91. Epub 2009 Oct 28. PMID: 19902018

Article Published Date : Nov 01, 2009

Study Type : Animal Study

Additional Links

Substances : Hesperidin, Orange

Diseases : Hyperuricemia

[+]

Orange juice attenuated cardiac remodeling in infarcted rats and HO-1 may be play an important role in this process.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Arq Bras Cardiol. 2021 06 ;116(6):1127-1136. PMID: 34133599

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Orange

Diseases : Myocardial Infarction

Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation

[+]

Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin induced toxicity.Apr 01, 2010

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Pubmed Data : Am J Clin Nutr. 2010 Apr;91(4):940-9. Epub 2010 Mar 3. PMID: 20200256

Article Published Date : Apr 01, 2010

Study Type : Animal Study

Additional Links

Substances : Orange

Diseases : Endotoxemia, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Matrix metalloproteinase-2 (MMP-2) inhibitor

[+]

Orange peel extract and physical exercise synergistically ameliorate type 2 diabetes mellitus-induced dysmetabolism.Jun 30, 2023

Click here to read the entire abstract

Pubmed Data : J Med Food. 2023 Jul ;26(7):470-479. Epub 2023 Jun 28. PMID: 37379466

Article Published Date : Jun 30, 2023

Study Type : Animal Study

Additional Links

Substances : Citrus Peel , Orange

Diseases : Diabetes Mellitus: Type 2, Insulin Resistance

Therapeutic Actions : Exercise

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic

Additional Keywords : Plant Extracts, Synergistic

[+]

Orange peel extract has chemopreventive properties against lesions in the mouse mammary gland.Mar 01, 2007

Click here to read the entire abstract

Pubmed Data : J Med Food. 2007 Mar;10(1):18-24. PMID: 17472462

Article Published Date : Mar 01, 2007

Study Type : Animal Study

Additional Links

Substances : Orange

Diseases : Breast Cancer

Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Chemopreventive

Additional Keywords : Plant Extracts

[+]

Orange peel extract inhibited tumorigenesis in this preclinical mouse model of adenomatous polyposis and increases programmed cell death. Mar 01, 2007

Click here to read the entire abstract

Pubmed Data : J Med Food. 2007 Mar;10(1):11-7. PMID: 17472461

Article Published Date : Mar 01, 2007

Study Type : Animal Study

Additional Links

Substances : Citrus Peel , Orange

Diseases : Adenomatous Polyposis Coli, Intestinal Cancer, Intestinal Polyps

Pharmacological Actions : Anticarcinogenic Agents, Apoptotic

Additional Keywords : Plant Extracts

[+]

Orange peel flavonoids inhibit experimental adjuvant-induced rat arthritis.May 01, 2010

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2010 May;35(10):1298-301. PMID: 20707201

Article Published Date : May 01, 2010

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Orange

Diseases : Arthritis, Inflammation, Osteoarthritis

Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Adjuvant-Induced Injury, Plant Extracts

[+]

Orange peels and Chlorella vulgaris supplementation ameliorate gamma radiation-induced oxidative stress.Sep 26, 2023

Click here to read the entire abstract

Pubmed Data : Cell Biochem Funct. 2023 Sep 27. Epub 2023 Sep 27. PMID: 37756035

Article Published Date : Sep 26, 2023

Study Type : Animal Study

Additional Links

Substances : Chlorella (Algae), Fruit Peel, Orange

Diseases : Oxidative Stress, Radiation

Pharmacological Actions : Antioxidants, Radioprotective, Transforming growth factor beta (TGF-β) upregulation

[+]

Orange pulp improved bone quality in a rat model of male osteoporosis.Apr 01, 2009

Click here to read the entire abstract

Pubmed Data : J Med Food. 2009 Apr;12(2):298-303. PMID: 19459729

Article Published Date : Apr 01, 2009

Study Type : Animal Study

Additional Links

Substances : Orange

Diseases : Osteoporosis: Male

[+]

Pera and Moro orange juices attenuated cardiac remodeling induced by doxorubicin.Jun 01, 2021

Click here to read the entire abstract

Pubmed Data : Nutrition. 2021 Jun 2 ;91-92:111350. Epub 2021 Jun 2. PMID: 34265580

Article Published Date : Jun 01, 2021

Study Type : Animal Study

Additional Links

Substances : Orange

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Cardioprotective, Chemoprotective Agents

[+]

Protective and anticancer effects of orange peel extract and naringin in doxorubicin treated esophageal cancer stem cell xenograft tumor mouse model.Nov 06, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2019 Nov 7 ;121:109594. Epub 2019 Nov 7. PMID: 31707344

Article Published Date : Nov 06, 2019

Study Type : Animal Study

Additional Links

Substances : Citrus naringin, Citrus Peel , Orange

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Cancer Stem Cells

[+]

Protective effect of the combination of essential oil from patchouli and tangerine peel against gastric ulcer,Jan 09, 2022

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2022 Jan 10 ;282:114645. Epub 2021 Sep 13. PMID: 34530094

Article Published Date : Jan 09, 2022

Study Type : Animal Study

Additional Links

Substances : Citrus Peel , Orange, Patchouli

Diseases : Gastric Ulcer

Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective

[+]

Protective effects of orange peel aqueous extract and hesperidin on oxidative stress and peptic ulcer induced by alcohol.Aug 13, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Lipids Health Dis. 2017 Aug 14 ;16(1):152. Epub 2017 Aug 14. PMID: 28806973

Article Published Date : Aug 13, 2017

Study Type : Animal Study

Additional Links

Substances : Citrus Peel , Hesperidin, Orange

Diseases : Alcohol Toxicity , Gastric Ulcer, Oxidative Stress

Pharmacological Actions : Anti-Ulcer Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Drug: Omeprazole, Plant Extracts

[+]

Red orange and lemon extract could prevent the renal damage induced by diabetic nephropathy.May 24, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Med. 2020 May 25 ;9(5). Epub 2020 May 25. PMID: 32466228

Article Published Date : May 24, 2020

Study Type : Animal Study

Additional Links

Substances : Lemon, Orange

Diseases : Diabetic Nephropathy

Pharmacological Actions : Renoprotective

Additional Keywords : Plant Extracts

[+]

Red orange and lemon extract prevents the renal toxicity induced by ochratoxin A in rats.Jan 02, 2020

Click here to read the entire abstract

Pubmed Data : J Cell Physiol. 2020 Jan 3. Epub 2020 Jan 3. PMID: 31898818

Article Published Date : Jan 02, 2020

Study Type : Animal Study

Additional Links

Substances : Lemon, Orange

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Anti-Fibrotic, Renoprotective

Problem Substances : Ochratoxin A

[+]

Sweet Orange peel has antithyroidal activity which may be therapeutic in hyperthyroidism. Jun 01, 2008

Click here to read the entire abstract

Pubmed Data : J Med Food. 2008 Jun;11(2):376-81. PMID: 18598183

Article Published Date : Jun 01, 2008

Study Type : Animal Study

Additional Links

Substances : Orange, Sweet Orange

Diseases : Hyperthyroidism

[+]

The navel orange peel hydroethanolic extract, naringin, and naringenin induced potential hepatopreventive effects.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:2745352. Epub 2019 Mar 26. PMID: 31049130

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Citrus naringin, Citrus Peel , Naringenin , Orange

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Apoptotic, Hepatoprotective

[+]

The use of orange, tangerine, and grapefruit peels as dietary supplements which offers potential life span promoting properties.Jan 31, 2021

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Pubmed Data : J Food Biochem. 2021 Feb ;45(2):e13616. Epub 2021 Feb 3. PMID: 33533492

Article Published Date : Jan 31, 2021

Study Type : Insect Study

Additional Links

Substances : Grapefruit, Orange

Diseases : Aging, Cognitive Decline/Dysfunction

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

This study showed some possible biochemical basis underlying the use of orange peels infusion in erectile dysfunction management.Jul 25, 2019

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Pubmed Data : Andrologia. 2019 Jul 26:e13371. Epub 2019 Jul 26. PMID: 31347717

Article Published Date : Jul 25, 2019

Study Type : Animal Study

Additional Links

Substances : Citrus Peel , Orange

Diseases : Erectile Dysfunction

[+]

Antiproliferative activity of Citrus juices and HPLC evaluation of their flavonoid composition.Aug 31, 2007

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Pubmed Data : Fitoterapia. 2007 Sep ;78(6):426-9. Epub 2007 May 23. PMID: 17628348

Article Published Date : Aug 31, 2007

Study Type : In Vitro Study

Additional Links

Substances : Orange

Diseases : Promyelocytic leukemia

Pharmacological Actions : Antiproliferative

Additional Keywords : Phytotherapy

[+]

Antibiofilm efficacies of flavonoid-rich sweet orange waste extract against dual-species biofilms.Apr 27, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pathogens. 2023 Apr 28 ;12(5). Epub 2023 Apr 28. PMID: 37242327

Article Published Date : Apr 27, 2023

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids, Orange

Diseases : Steptococcus Mutans Infections

Pharmacological Actions : Antimicrobial

Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation

[+]

Antioxidant and anticancer activities of essential oil from Gannan navel orange peel.Aug 21, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2017 Aug 22 ;22(8). Epub 2017 Aug 22. PMID: 28829378

Article Published Date : Aug 21, 2017

Study Type : In Vitro Study

Additional Links

Substances : Citrus Peel , Orange

Diseases : Lung Cancer, Prostate Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Essential Oils

[+]

Blond and red fleshed sweet orange juice had potential chemopreventive effects on the loucy leukemia cell line.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(15):6491-9. PMID: 26434864

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Bergamot orange, Orange

Diseases : Leukemia: T-cell acute Lymphoblastic

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive

[+]

C. sinensis fruit juice has a potential for causing both anti-proliferative and cytostatic effects on fast proliferating cells and hence cancerous cells.Aug 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Appl Basic Med Res. 2014 Sep ;4(Suppl 1):S20-2. PMID: 25298937

Article Published Date : Aug 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Orange

Diseases : Cancers: All

Pharmacological Actions : Antiproliferative

Additional Keywords : Fruit Juice, Superiority of Natural Substances versus Drugs

[+]

Carotenoids extracted from red paprika, Valencia orange and Golden delicious apple exhibit anti-H. pylori and anti-multidrug resistance activity.Aug 01, 2005

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Pubmed Data : Phytother Res. 2005 Aug;19(8):700-7. PMID: 16177974

Article Published Date : Aug 01, 2005

Study Type : In Vitro Study

Additional Links

Substances : Apple: Golden Delicious, Carotenoids, Orange, Paprika

Diseases : Cancers: All, Cancers: Multi-Drug Resistant, Helicobacter Pylori Infection

Pharmacological Actions : Anti-Bacterial Agents, Antioxidants, Chemosensitizer

[+]

Citrus fruit extracts represent an important source of antioxidants and reduces advanced glycation end products (AGEs).Sep 30, 2010

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20882960

Article Published Date : Sep 30, 2010

Study Type : In Vitro Study

Additional Links

Substances : Orange

Diseases : Diabetes: Oxidative Stress, Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Comparative effects of five polymethoxyflavones purified from Citrus tangerina on inflammation and cancer.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Nutr. 2022 ;9:963662. Epub 2022 Sep 8. PMID: 36159482

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Orange

Diseases : Cancers: All, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-10 upregulation, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Compounds from orange peel have anti-cancer activity against breast cancer cells. Dec 01, 2007

Click here to read the entire abstract

Pubmed Data : Mol Nutr Food Res. 2007 Dec;51(12):1478-84. PMID: 17979096

Article Published Date : Dec 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Orange

Diseases : Breast Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic

[+]

Compounds from orange peel inhibit the proliferation of promyelocytic leukemia (HL-60) cells.May 15, 2007

Click here to read the entire abstract

Pubmed Data : Bioorg Med Chem. 2007 May 15;15(10):3381-9. Epub 2007 Mar 13. PMID: 17391969

Article Published Date : May 15, 2007

Study Type : In Vitro Study

Additional Links

Substances : Orange

Diseases : Promyelocytic leukemia

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic

Additional Keywords : Plant Extracts

[+]

Compounds from sweet orange peel inhibit the growth of human lung cancer cells. Mar 01, 2009

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Pubmed Data : Mol Nutr Food Res. 2009 Mar;53(3):398-406. PMID: 19065586

Article Published Date : Mar 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids, Orange

Diseases : Lung Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Antiproliferative , Apoptotic

[+]

Extracellular vesicles derived from Citrus sinensis modulate inflammatory genes and tight junctions in a human model of intestinal epithelium.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Nutr. 2021 ;8:778998. Epub 2021 Nov 24. PMID: 34901124

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Orange

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Exosomes, Gene Expression Regulation

[+]

Inhibition of metalloproteinase and proteasome activities in colon cancer cells by citrus peel extracts.Aug 31, 2015

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Pubmed Data : J Basic Clin Physiol Pharmacol. 2015 Sep ;26(5):471-7. PMID: 26030791

Article Published Date : Aug 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Grapefruit, Orange, Pomelo

Diseases : Colon Cancer

Pharmacological Actions : Anti-metastatic, Proteasome Inhibitors

Additional Keywords : Plant Extracts

[+]

Limonene and essential oil from orange has gastroprotective actions. Aug 14, 2009

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Pubmed Data : Chem Biol Interact. 2009 Aug 14;180(3):499-505. Epub 2009 May 3. PMID: 19410566

Article Published Date : Aug 14, 2009

Study Type : In Vitro Study

Additional Links

Substances : D-Limonene, Orange

Diseases : Gastric Ulcer

Pharmacological Actions : Gastroprotective

[+]

M. oleifera and C. sinensis extracts have effectively blocked MRSA and ESBL development in the biofilm matrix.Dec 27, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cureus. 2020 Dec 28 ;12(12):e12337. Epub 2020 Dec 28. PMID: 33520533

Article Published Date : Dec 27, 2020

Study Type : In Vitro Study

Additional Links

Substances : Moringa oleifera, Orange

Diseases : Pseudomonas aeruginosa, Staphylococcus aureus: Methicillin-resistant (MRSA)

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation

[+]

Orange juice inhibits prostate cell proliferation. Apr 01, 2006

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Pubmed Data : Fitoterapia. 2006 Apr;77(3):151-5. Epub 2006 Feb 23. PMID: 16530345

Article Published Date : Apr 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Orange

Diseases : Prostatic Hyperplasia: Benign

Pharmacological Actions : Antiproliferative

Additional Keywords : Plant Extracts

[+]

Polymethoxylated flavones from orange peels inhibit cell proliferation in a 3D cell model of human colorectal cancer.Jan 08, 2018

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2018 Jan 9:1-10. Epub 2018 Jan 9. PMID: 29313727

Article Published Date : Jan 08, 2018

Study Type : In Vitro Study

Additional Links

Substances : Fruit Peel, Nobiletin , Orange, Tangeretin

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Cancer Stem Cells

[+]

Red orange extract exerts anti-inflammatory effects probably through the suppression of COX-2 and iNOS expression.Sep 01, 2010

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Pubmed Data : Nat Prod Res. 2010 Sep;24(15):1469-80. PMID: 20812134

Article Published Date : Sep 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Orange

Diseases : Inflammation, Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Nitric Oxide Inhibitor

[+]

Red orange extract protects against UVB-induced damage in human skin cells.Jan 01, 2007

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Pubmed Data : Biofactors. 2007;30(2):129-38. PMID: 18356584

Article Published Date : Jan 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Orange

Diseases : Skin Diseases: Photo-Aging, Sunburn

Pharmacological Actions : Apoptotic

Additional Keywords : Plant Extracts

[+]

Role of citrus fruit juices in prevention of kidney stone disease.Nov 16, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2021 Nov 17 ;13(11). Epub 2021 Nov 17. PMID: 34836376

Article Published Date : Nov 16, 2021

Study Type : Review

Additional Links

Substances : Grapefruit, Lemon, Orange

Diseases : Kidney Stones

Additional Keywords : Risk Reduction

Problem Substances : Antacids: Aluminium-Containing

[+]

The essential oils of Caraway (C. carvi), Lavender (L. angustifolia), Ajwain (T.copticum), and Orange (C. aurantium) may have therapeutic value in treating intestinal dysbios. Dec 01, 2009

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Pubmed Data : Altern Med Rev. 2009 Dec;14(4):380-4. PMID: 20030464

Article Published Date : Dec 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Ajwain, Caraway , Lavender, Orange

Diseases : Dysbiosis

Pharmacological Actions : Anti-Bacterial Agents

[+]

The results in this study indicate that C. sinensis seed oil and non-oil extracts possess antioxidant, and antibacterial and antifungal properties.Sep 29, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Prev Nutr Food Sci. 2020 Sep 30 ;25(3):280-285. PMID: 33083377

Article Published Date : Sep 29, 2020

Study Type : In Vitro Study

Additional Links

Substances : Orange

Diseases : Aspergillosis, Candida Albicans, Oxidative Stress

Pharmacological Actions : Antimicrobial, Antioxidants

[+]

The results presented here highlight C. sinensis as a promising source of antileishmanial agents.Nov 30, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharm Biol. 2017 Dec ;55(1):1780-1786. PMID: 28524774

Article Published Date : Nov 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Orange

Diseases : Leishmaniasis

Pharmacological Actions : Leishmanicidal

Additional Keywords : Phytotherapy, Plant Extracts

[+]

This research demonstrated efficacy and safety of Iranian herbal medicines in alleviating PMS.Feb 28, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Avicenna J Phytomed. 2018 Mar-Apr;8(2):96-113. PMID: 29632841

Article Published Date : Feb 28, 2018

Study Type : Review

Additional Links

Substances : Chamomile, Chaste Tree (Chasteberry), Curcumin, Fennel, Flaxseed, Ginger, Lemon Balm, Orange, Saffron, St. Johns Wort, Valerian, Wheat Germ, Zataria multiflora

Diseases : Premenstrual syndrome

Additional Keywords : Traditional Iranian Medicine

[+]

This study reports on the potential involvement of the colonic microbiota in the overall bioavailability of orange juice polyphenols.Feb 28, 2015

Click here to read the entire abstract

Pubmed Data : Mol Nutr Food Res. 2015 Mar ;59(3):465-75. Epub 2015 Jan 22. PMID: 25545994

Article Published Date : Feb 28, 2015

Study Type : In Vitro Study

Additional Links

Substances : Orange, Polyphenols

Additional Keywords : Bioavailability, Microbiota

[+]

Unveiling the nature's fruit basket to computationally identify Citrus sinensis csi-mir169-3p as a probable plant miRNA against SARS-CoV-2 genome.Jun 30, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Comput Biol Med. 2022 Jul ;146:105502. Epub 2022 Apr 8. PMID: 35605482

Article Published Date : Jun 30, 2022

Study Type : In Vitro Study

Additional Links

Substances : Apple, Grape, Orange, Peach

Diseases : Coronavirus Infection

Pharmacological Actions : Immunomodulatory

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This meta-analysis demonstrates the beneficial effects of chronic orange juice consumption on blood pressure and HDL-C in overweight and obese adults.Nov 27, 2022

Ambient odor of orange in a dental office reduces anxiety and improves mood in female patients.Dec 13, 1901

Ambient odors of orange and lavender reduce anxiety and improve mood in a dental office.Sep 15, 2005

Antioxidant efficacy of a standardized red orange extract in elderly subjects.Oct 10, 2022

Aroma-massage therapy with ginger and orange oil have potential as an alternative method for short-term knee pain relief.May 01, 2006

Aromatherapy blend of thyme, orange, clove bud, and frankincense boosts energy levels in post-COVID-19 female patients.Mar 23, 2022

Aromatherapy is a noninvasive and effective method to help women overcome their anxiety during labor.Oct 31, 2015

Blood orange juice intake modulates plasma and PBMC microRNA expression in overweight and insulin resistance women.Nov 24, 2022

Chronic daily consumption of flavanone-rich 100% orange juice over 8 week was beneficial for cognitive function in healthy older adults.Feb 28, 2015

Common fruit provide a dietary source of melatonin.Jan 16, 2013

Comparing effects of aromatherapy with lavender essential oil and orange essential oil on fatigue of hemodialysis patients.Jul 31, 2019

Consumption of fruits that are high in antioxidants could represent a useful means to improve the antioxidant status of NAFLD.Jul 13, 2016

Consumption of orange fermented beverage improves antioxidant status and reduces peroxidation lipid and inflammatory markers.Apr 30, 2018

Dietary consumption of fruits high in antioxidant nutrients reduce the risk of incident cervical intraepithelial neoplasia.Sep 01, 2010

Dietary flavonoid intake at midlife and healthy aging in women.Nov 30, 2014

Effect of the consumption of hesperidin in orange juice on the transcriptomic profile of subjects with elevated blood pressure.Nov 30, 2021

Effects of blood orange juice intake on antioxidant bioavailability and on different markers related to oxidative stress.Feb 22, 2005

Effects of tangerine essential oil on brain waves, moods, and sleep onset latency.Oct 20, 2020

Flavanone intake is inversely associated with esophageal cancer risk and may account, with vitamin C, for the protective effect of fruit, especially citrus fruit, on esophageal cancer. Apr 10, 2000

Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans.Nov 30, 2016

Flavonoid-rich orange juice intake and altered gut microbiome in young adults with depressive symptoms.Jun 17, 2020

Hesperidin-enriched orange juice could be a useful co-adjuvant tool for BP and pulse pressures management in pre- and stage-1 hypertensive individuals.Jul 12, 2020

In healthy subjects the concomitant intake of orange juice may prevent the low-grade inflammatory reaction induced by a fatty meal.Jan 31, 2015

Orange juice consumption is associated with better diet quality, improved nutrient adequacy and a decreased risk for obesity.Dec 11, 2012

Orange juice ingestion and supplemental vitamin C are equally effective at reducing plasma lipid peroxidation.Nov 30, 2003

Orange juice intake improved depressive symptoms in young adults with major depressive disorder.Dec 27, 2022

Orange juice may have a therapeutic effect in reducing stone-forming risk. Nov 01, 2006

Orange juice raises HDL cholesterol in subjects with high cholesterol. Nov 01, 2000

Orange juice vs vitamin C: effect on hydrogen peroxide-induced DNA damage in mononuclear blood cells.Mar 31, 2007

Orange juice was a convenient food in the diet of patients due to the increase in antioxidant capacity and decreased inflammation and cholesterol.Dec 31, 2016

Photoprotective and antiaging effects of a standardized red orange.May 26, 2022

Supplementation with orange and blackcurrant juice improves inflammatory markers in patients with peripheral arterial disease. Jan 01, 2009

The consumption of an orange juice with a high content of flavanones improved oxidative stress and inflammatory biomarkers.Dec 31, 2016

The effect of a citrus and pomegranate complex on physical fitness and mental well-being in healthy elderly.Dec 31, 2021

The oral supplement assessed in this study safely and effectively promotes significant hair growth in women with temporary hair thinning.Oct 31, 2012

These findings suggest a protective association between dietary intake of flavonoids and the likelihood of having age-related macular degeneration.Jul 05, 2018

These results suggested that a daily consumption of orange had a positive effect on the intestinal microbiota and metabolic biomarkers of young women.Jan 31, 2019

Tropical fruit consumption increases the serum melatonin concentrations and also raises the antioxidant capacity in the serum of healthy volunteers in proportion to serum melatonin levels.Oct 04, 2012

Anti-inflammatory effect of a flavonoid-rich extract of orange juice in adult zebrafish subjected to Vibrio anguillarum-induced enteritis.Apr 26, 2020

A standardized extract prepared from red orange and lemon wastes blocks high-fat diet-induced hyperglycemia and hyperlipidemia.Jul 14, 2021

A variety of orange by-products could be used as food supplements in the potential amelioration of inflammatory bowel diseases.Sep 18, 2018

Ameliorating effect of Citrus trifoliata L. fruits extract on motor incoordination, neurodegeneration and oxidative stress in Parkinson's disease model.Sep 01, 2023

Antidepressant-like effect of Citrus sinensis essential oil and its main component limoneneApr 01, 2019

Blood orange juice intake changes specific bacteria of gut microbiota associated with cardiometabolic biomarkers.Dec 31, 2022

Citrus juice positively affects serum antioxidant status and bone strength.May 01, 2006

Effects of Moro orange juice on some metabolic and morphological parameters in obese and diabetes.Aug 05, 2020

Effects of orange essential oil on intestinal microflora in mice.Feb 05, 2019

Enriching orange with leaf and stem juice results in a functional and nutritious beverage that protects against obesity and its associated health issues.Feb 24, 2022

Flavonoids bergamot and orange juices may be of use in preventing oxidative cell injury and pave the way for further research into a novel healthy approach to avoid lung disorders.Dec 31, 2014

Inhibition of azoxymethane-induced colon cancer by orange juice.Dec 31, 1999

Orange fruit peel extract attenuates chemotherapy-induced toxicity.Oct 03, 2021

Orange juice and hesperetin supplementation have significant therapeutic activity in hyperuricemic rats. Nov 01, 2009

Orange juice attenuated cardiac remodeling in infarcted rats and HO-1 may be play an important role in this process.Dec 31, 2020

Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin induced toxicity.Apr 01, 2010

Orange peel extract and physical exercise synergistically ameliorate type 2 diabetes mellitus-induced dysmetabolism.Jun 30, 2023

Orange peel extract has chemopreventive properties against lesions in the mouse mammary gland.Mar 01, 2007

Orange peel extract inhibited tumorigenesis in this preclinical mouse model of adenomatous polyposis and increases programmed cell death. Mar 01, 2007

Orange peel flavonoids inhibit experimental adjuvant-induced rat arthritis.May 01, 2010

Orange peels and Chlorella vulgaris supplementation ameliorate gamma radiation-induced oxidative stress.Sep 26, 2023

Orange pulp improved bone quality in a rat model of male osteoporosis.Apr 01, 2009

Pera and Moro orange juices attenuated cardiac remodeling induced by doxorubicin.Jun 01, 2021

Protective and anticancer effects of orange peel extract and naringin in doxorubicin treated esophageal cancer stem cell xenograft tumor mouse model.Nov 06, 2019

Protective effect of the combination of essential oil from patchouli and tangerine peel against gastric ulcer,Jan 09, 2022

Protective effects of orange peel aqueous extract and hesperidin on oxidative stress and peptic ulcer induced by alcohol.Aug 13, 2017

Red orange and lemon extract could prevent the renal damage induced by diabetic nephropathy.May 24, 2020

Red orange and lemon extract prevents the renal toxicity induced by ochratoxin A in rats.Jan 02, 2020

Sweet Orange peel has antithyroidal activity which may be therapeutic in hyperthyroidism. Jun 01, 2008

The navel orange peel hydroethanolic extract, naringin, and naringenin induced potential hepatopreventive effects.Dec 31, 2018

The use of orange, tangerine, and grapefruit peels as dietary supplements which offers potential life span promoting properties.Jan 31, 2021

This study showed some possible biochemical basis underlying the use of orange peels infusion in erectile dysfunction management.Jul 25, 2019

Antiproliferative activity of Citrus juices and HPLC evaluation of their flavonoid composition.Aug 31, 2007

Antibiofilm efficacies of flavonoid-rich sweet orange waste extract against dual-species biofilms.Apr 27, 2023

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96 Abstracts with Orange Research