Organosulfur Compounds

Name	AC	CK
Oxidative Stress	42	98
Inflammation	20	53
Athletic Performance: Recovery	4	40
Prostate Cancer	24	39
Breast Cancer	29	38
Colon Cancer	16	30
DNA damage	10	30
Helicobacter Pylori Infection	7	28
Breast Cancer: Triple Negative	7	27
Osteoarthritis	4	27
Cancers: All	15	24
Pancreatic Cancer	15	24
Autism Spectrum Disorders	3	21
Allergic Rhinitis	2	20
Schizophrenia	2	20
Bladder Cancer	8	19
Diabetes Mellitus: Type 2	7	18
Melanoma	6	17
Alzheimer's Disease	8	16
Depression	4	16
Insulin Resistance	4	16
Liver Cancer	13	16
Immune Disorders: Low Immune Function	4	15
Chemotherapy-Induced Toxicity: Cisplatin	8	14
Endothelial Dysfunction	6	14
Fatty Liver	3	14
Lipopolysaccharide-Induced Toxicity	11	14
Lung Cancer	10	14
Prostate Cancer: Prevention	4	14
Autism	2	12
Cancer Metastasis	10	12
Diesel Exhaust Particle Toxicity	3	12
Glutathione Deficiency	3	12
Muscle Damage: Exercise-Induced	2	12
Air Pollution Linked Toxicity	2	11
Skin Diseases	2	11
Anemia: Sickle Cell	1	10
Asthma	1	10
Athletic Performance	1	10
Bipolar Disorder	1	10
Bladder Degeneration	1	10
COPD	1	10
Cancers: Drug Resistant	5	10
Cognitive Decline/Dysfunction	5	10
Cystic Fibrosis	1	10
Cystitis	1	10
Gastritis	1	10
Hyperhomocysteinemia	1	10
Hyperinsulinism	1	10
Influenza in Swine	1	10
Interstitial Lung Diseases	1	10
Lung Diseases	1	10
Lymphopenia	1	10
Neutrophils: Elevated	1	10
Obesity	5	10
Osteoarthritis: Knee	1	10
Prostate: PSA Doubling	1	10
Pulmonary Fibrosis	1	10
Radical Prostatectomy	1	10
Respiratory Diseases	1	10
Rosacea	1	10
Swine Flu Associated Virus	1	10
Thrush	1	10
Cerebral Ischemia	5	9
Gastric Cancer	8	9
Colorectal Cancer	5	8
Chemically-Induced Liver Damage	5	7
Chemotherapy-Induced Toxicity: Doxorubicin	5	7
Hypoxia	5	7
Myocardial Ischemia	4	7
Neurodegenerative Diseases	5	7
Acetaminophen (Tylenol) Toxicity	3	6
Adenomatous Polyposis Coli	3	6
Hypertension	3	6
Spinal Cord Injuries	3	6
Testicular Injury: Chemical/Metal Induced	3	6
Cancer Stem Cells	5	5
Diabetic Nephropathy	3	5
Drug-Induced Toxicity: Indomethacin	3	5
Endothelial Damage	1	5
Gastric Ulcer	3	5
Glioblastoma	4	5
Ovarian Cancer	5	5
Pesticide Toxicity	3	5
Aflatoxicosis	3	4
Arteriosclerosis	2	4
Aspirin-Induced Toxicity	2	4
Brain Inflammation	3	4
Brain Injury: Traumatic	2	4
Brain: Microglial Activation	2	4
Cadmium Poisoning	3	4
Cardiovascular Diseases	4	4
Cervical Cancer	4	4
Chronic Kidney Disease (CKD)	2	4
Diabetic Complications	2	4
Head and Neck Cancer	4	4
Hydrogen Peroxide Induced Toxicity	4	4
Intestinal Polyps	2	4
Ischemia	2	4
Lead Poisoning	2	4
Leishmaniasis	2	4
Leukemia	4	4
Liver Disease	2	4
Lung Injury: Acute	2	4
Myocardial Infarction	2	4
NSAID-induced toxicity	2	4
Oral Cancer	3	4
Organ Transplantation: Pancreatic Islet Cells	2	4
Parkinson's Disease	4	4
Sepsis	2	4
Skin Cancer	3	4
Skin Cancer: Prevention	2	4
Traumatic Brain Injury	2	4
Advanced Glycation End products (AGE)	2	3
Aging Skin	2	3
Arsenic Poisoning	2	3
Benzo[a]pyrene-induced Toxicity	2	3
Blood-Brain-Barrier Disorders	2	3
Brain Cancer	3	3
Brain Damage	2	3
Carcinoma: Non-Small-Cell Lung	2	3
Cardiac Hypertrophy	2	3
Chemotherapy-Induced Toxicity	2	3
Colon Cancer: Prevention	2	3
Diabetes Mellitus: Type 1: Prevention	2	3
Glioma	3	3
Intestinal Diseases	2	3
Lipid Peroxidation	2	3
Liver Cancer: Prevention	2	3
Liver Damage: Aflatoxin-Induced	2	3
Low Disorders: Low TH1	2	3
Lymphoma	2	3
Melanoma: Metastatic	2	3
Multiple Myeloma	2	3
Nasopharyngeal Cancer	2	3
Neurologic Disorders	2	3
Osteosarcoma	2	3
Petroleum Exposure And Toxicity	2	3
Polycyclic aromatic hydrocarbon (PAH) toxicity	2	3
Promyelocytic leukemia	3	3
Rheumatoid Arthritis	2	3
Skin Diseases: Photo-Aging	2	3
Aging	2	2
Alcohol Toxicity	1	2
Alcoholic Liver Disease	1	2
Amebiasis	1	2
Amphetamine Addiction/Withdrawal	1	2
Antibiotic Toxicity	1	2
Anxiety Disorders	1	2
Arterial Calcification	1	2
Arterial Plaque	1	2
Arterial Thickening	1	2
Asphyxia	1	2
Atherosclerosis	1	2
Bacterial Infections and Mycoses	2	2
Bladder Dysfunction	1	2
Bladder Outlet Obstruction	1	2
Brain Edema	1	2
Brain Hypoxia	2	2
Breast Cancer: Metastatic	2	2
Cancers: Multi-Drug Resistant	1	2
Candida Infection	2	2
Carbon Monoxide Poisoning	1	2
Chemical Exposure	1	2
Chemical Weapon Agent Injury	1	2
Cholangiocarcinoma	1	2
Colitis	1	2
Depressive Disorder	1	2
Diabetes Mellitus: Type 1	1	2
Diabetes: Cognitive Dysfunction	1	2
Diabetes: Memory Problems	1	2
Drug-Induced Toxicity: Cyclosporine	1	2
Duchenne's Muscular Dystrophy	1	2
Epstein-Barr Virus Infections	1	2
Eye Damage	1	2
Fluoride Toxicity	1	2
Gastrointestinal Cancer	1	2
Gout	1	2
Hearing Loss	1	2
Heart Failure	1	2
Hypertension: Pulmonary	1	2
Hypoglycemia	2	2
Immune Dysregulation: TH1/TH2 imbalance	1	2
Intima Media Thickening	1	2
Intoxication	1	2
Kidney Damage: Chemically-Induced	1	2
Kidney Diseases	1	2
Kidney Stones	1	2
Light Sensitivity	1	2
Liver Damage	1	2
Low Immune Function: Natural Killer Cells	1	2
Malathion Toxicity	1	2
Mercury Poisoning	1	2
Muscle Fatigue	1	2
Muscle Soreness	1	2
Mycobacterium tuberculosis	1	2
Nephropathy	1	2
Neuropathic Pain	1	2
Nicotine/Tobacco Toxicity	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Obsessive-Compulsive Disorder	1	2
Organ Transplantation	1	2
Pancreatitis	1	2
Respiratory Syncytial Virus Infections	1	2
Respiratory Tract Infections	1	2
Right Ventricular Hypertrophy	1	2
Salivary Gland Adenoid Cystic Carcinoma.	2	2
Salivary Gland Diseases	2	2
Schistosomiasis	1	2
Schwannoma: Vestibular	1	2
Seizures	1	2
Serotonin Disorders	1	2
Smoking	1	2
Streptococcus infections: Group A	2	2
Stroke	1	2
Stroke: Recovery	1	2
Subarachnoid hemorrhage	1	2
Tumors	2	2
Uremia	1	2
Acute Myeloid Leukemia	1	1
Allergies	1	1
Androgen-Induced Diseases	1	1
Aortic Plaques	1	1
Aphthous Ulcer	1	1
Aspergillosis	1	1
Bone Destructive Diseases: Over-Active Osteoclasts	1	1
Brain Injury: Hippocampal Damage	1	1
Brain: Oxidative Stress	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Breast Cancer: Prevention	1	1
Candidiasis	1	1
Canker Sore	1	1
Cardiovascular Disease: Prevention	1	1
Cholesterol: LDL/HDL ratio	1	1
Chronic Myeloid Leukemia	1	1
Colorectal Tumors	1	1
Dementia	1	1
Dental Caries	1	1
Dopamine Deficiency	1	1
Drug-Induced Toxicity	1	1
Dystrophic retinal detachment (DRD)	1	1
Encephalomyelitis	1	1
Endometrial Cancer	1	1
Excitotoxicity	1	1
Fibrosarcoma	1	1
Fibrosis	1	1
Fungal Infection	1	1
Gastrointestinal Diseases	1	1
Gastrointestinal Inflammation	1	1
Giardiasis	1	1
Gonorrhea	1	1
Gram-Negative Bacterial Infections	1	1
Gram-Positive Bacterial Infections	1	1
HDL: Low	1	1
HIV Infections	1	1
Hepatitis	1	1
Hepatitis C	1	1
Hepatitis: Lectin-Induced (concanavalin)	1	1
Heterocyclic Aromatic Amine Induced Toxicity	1	1
Hyperglycemia	1	1
Hyperlipidemia	1	1
IgE-Mediated Hypersensitivity	1	1
Infection: Antibiotic Resistant	1	1
Keloid	1	1
Kidney Damage	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Leukemia: Chronic Lymphocytic Leukemia (CLL)	1	1
Low Human Growth Hormone	1	1
Lung Cancer: Prevention	1	1
Lymphoma: B-Cell	1	1
Lymphoma: Mantle Cell	1	1
MRSA	1	1
Macular Degeneration	1	1
Medulloblastoma	1	1
Melanism	1	1
Methicillin-resistant Staphylococcus aureus	1	1
Microcystis aeruginosa	1	1
Mitochondrial Diseases	1	1
Multiple Sclerosis	1	1
Napthalene-Induced Toxicity	1	1
Oral Cancer: Prevention	1	1
Osteoporosis: Over-active Osteoclasts	1	1
Pancreatic Cancer Stem Cell	1	1
Periodontal Diseases	1	1
Pneumococcal Infections	1	1
Prediabetes	1	1
Pseudomonas Infections	1	1
Restenosis	1	1
Retinal Diseases	1	1
Squamous cell carcinoma	1	1
Staphylococcus aureus infection	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Staphylococcus epidermidis	1	1
Stomach Cancer	1	1
Streptococcus Infections	1	1
Streptococcus infections: Group B	1	1
Striatonigral Degeneration: Autosomal Dominant	1	1
Sunburn	1	1
Thyroid Cancer	1	1
Ultraviolet Radiation Induced Damage	1	1

Name	AC	CK
Antioxidants	91	219
Anti-Inflammatory Agents	65	167
Apoptotic	101	144
Anticarcinogenic Agents	76	128
Chemopreventive	55	106
Antiproliferative	63	100
Neuroprotective Agents	40	77
Nrf2 activation	39	77
Tumor Necrosis Factor (TNF) Alpha Inhibitor	25	41
Phase II Detoxification Enzyme Inducer	14	40
Cell cycle arrest	30	34
Cardioprotective	16	33
Interleukin-1 beta downregulation	20	33
Cytoprotective	7	28
Hepatoprotective	12	28
NF-kappaB Inhibitor	22	27
Anti-metastatic	21	26
Cyclooxygenase 2 Inhibitors	14	26
Interleukin-6 Downregulation	17	26
Chemotherapeutic	18	25
Glutathione Upregulation	5	24
Antineoplastic Agents	17	22
Anti-Allergic Agents	2	20
Histone deacetylase inhibitor	10	19
Enzyme Inhibitors	8	17
Antidepressive Agents	4	16
Chemosensitizer	13	16
Renoprotective	9	16
Anti-Apoptotic	9	15
Genoprotective	3	13
Matrix metalloproteinase-9 (MMP-9) inhibitor	9	13
Superoxide Dismutase Up-regulation	5	13
Chemoprotective Agents	7	12
Matrix metalloproteinase-2 (MMP-2) inhibitor	7	12
MicroRNA modulator	11	11
Anti-Bacterial Agents	10	10
Anticholesteremic Agents	1	10
Insulin Down-Regulation	1	10
Malondialdehyde Down-regulation	5	9
NF-E2-Related Factor-2 (Nrf2) Modulator	8	9
Heme oxygenase-1 up-regulation	6	7
Immunomodulatory	5	7
Antihypertensive Agents	3	6
Autophagy Up-regulation	4	6
Hypolipidemic	4	6
Anti-Angiogenic	4	5
Antifungal Agents	4	4
Antiviral Agents	3	4
Bcl-2 protein down-regulation	4	4
Gastroprotective	2	4
Heat Shock Protein Inducer	2	4
Leishmanicidal	2	4
Telomerase Inhibitor	4	4
Vascular Endothelial Growth Factor Inhibitors	2	4
Anti-Proliferative	2	3
Anti-Ulcer Agents	2	3
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	3
Radioprotective	2	3
Tumor Suppressor Protein p53 Upregulation	3	3
Angiogenesis Inhibitors	1	2
Anti-Anxiety Agents	1	2
Anti-Fibrotic	2	2
Anticonvulsants	1	2
Antimicrobial	2	2
Antinoceceptive	1	2
Autophagy Inhibitors	1	2
Detoxifier	2	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Hypotensive	1	2
Immunomodulatory: Th17 downregulation	1	2
Interleukin-17 downregulation	1	2
Interleukin-18 down-regulation	1	2
Interleukin-2 upregulation	1	2
Interleukin-8 downregulation	2	2
Leptin Down-Regulation	1	2
P21 Activation	2	2
Phase I Detoxification Enzyme Inducer	1	2
Photoprotective	1	2
Prostaglandin PGE2 downregulation	1	2
Proteasome Inhibitors	2	2
STAT3 Activation	1	2
Schistosomicides	1	2
Serotonergic	1	2
Vasodilator Agents	1	2
Wnt/β-catenin signaling pathway modulation	2	2
Anti Inflammatory	1	1
Anti-Glycation Agents	1	1
Anti-atherogenic	1	1
Antimitotic Agents	1	1
Antiparasitic Agents	1	1
Beta-Defensin-2 Up-Regulation	1	1
Caspase-3 Activation	1	1
Cell Differentiation Inducer	1	1
Cytotoxic	1	1
Estrogen Receptor Modulators	1	1
HMG-CoA reductase inhibitor	1	1
Hypoglycemic Agents	1	1
Immunostimulatory	1	1
Interferon Gamma Reducer	1	1
Interleukin-1 alpha downregulation	1	1
Interleukin-10 upregulation	1	1
Interleukin-4 upregulation	1	1
Postaglandin PGE2 downregulation	1	1
Quinone Reductase-Inducer	1	1
Radiopharmaceuticals	1	1
Radiosensitizer	1	1
Secretagogue	1	1
Survivin Down-Regulation	1	1
Vascular Cell Adhesion Molecule-1 Inhibitor	1	1
Vascular Endothelial Growth Factor Regulator	1	1
Wnt/β-catenin pathway down-regulation	1	1

[+]

Sulforaphane ameliorates lipid profile.Apr 07, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Nrf2 activation

[+]

Effect of supplemental antioxidant-based therapy on the oxidative stress level in COVID-19 patients.Feb 28, 2023

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Pubmed Data : Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2023 Mar 1 ;44(1):7-16. Epub 2023 Mar 29. PMID: 36987766

Article Published Date : Feb 28, 2023

Study Type : Human Study

Additional Links

Substances : Lycopene, Reishi Mushroom, Resveratrol, Sulforaphane

Diseases : Inflammation, Oxidative Stress

Pharmacological Actions : Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Effects of sulforaphane intake on processing speed and negative moods in healthy older adults.Dec 31, 2021

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Pubmed Data : Geriatr Gerontol Int. 2008 Dec;8(4):243-50. PMID: 19149835

Article Published Date : Dec 01, 2008

Study Type : Human Study

Additional Links

Substances : Cysteine (see N-Acetylcysteine), Theanine

Diseases : Influenza in Swine, Swine Flu Associated Virus

Additional Keywords : Drug-Plant-Vitamin Synergies

[+]

Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritisFeb 29, 2016

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Pubmed Data : Int J Immunopathol Pharmacol. 2016 Mar ;29(1):140-6. Epub 2015 Dec 18. PMID: 26684635

Article Published Date : Feb 29, 2016

Study Type : Human Study

Additional Links

Substances : Frankincense, MSM (Methylsulfonylmethane)

Diseases : Osteoarthritis: Knee

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors

[+]

Methylsulfonylmethane appears to dampen the release of inflammatory molecules in response to exercise.Dec 31, 2015

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Pubmed Data : J Sports Med (Hindawi Publ Corp). 2016 ;2016:7498359. Epub 2016 Oct 23. PMID: 27844051

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Substances : MSM (Methylsulfonylmethane)

Diseases : Inflammation, Muscle Damage: Exercise-Induced

Therapeutic Actions : Exercise

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Methylsulfonylmethane may favourably influence selected markers of exercise recovery.Sep 26, 2012

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Pubmed Data : J Int Soc Sports Nutr. 2012 Sep 27 ;9(1):46. Epub 2012 Sep 27. PMID: 23013531

Pubmed Data : J Pharm Pharmacol. 2011 Oct ;63(10):1290-4. Epub 2011 Aug 1. PMID: 21899544

Article Published Date : Oct 01, 2011

Study Type : Human Study

Additional Links

Substances : MSM (Methylsulfonylmethane)

Diseases : Athletic Performance: Recovery , Oxidative Stress

Pharmacological Actions : Antioxidants, Glutathione Upregulation

[+]

Polyphenol and methylsulfonylmethane supplementation improves immune, DAMP signaling, and inflammatory responses during recovery from all-out running efforts.Dec 31, 2020

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Pubmed Data : Front Physiol. 2021 ;12:712731. Epub 2021 Aug 31. PMID: 34531760

Pubmed Data : Am J Clin Nutr. 2019 Jul 3. Epub 2019 Jul 3. PMID: 31268126

Article Published Date : Jul 03, 2019

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Pubmed Data : Phytother Res. 2003 Jan;17(1):66-9. PMID: 20810543

Article Published Date : Jan 01, 2003

Study Type : Human Study

Additional Links

Substances : Sulforaphane

Diseases : Bladder Cancer, Bladder Degeneration, DNA damage

Pharmacological Actions : Chemopreventive, Genoprotective

[+]

Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.Dec 31, 2014

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Pubmed Data : Acta Medica (Hradec Kralove). 2001;44(3):97-100. PMID: 11811084

Article Published Date : Jan 01, 2001

Study Type : Human Study

Additional Links

Substances : Allicin

Diseases : Helicobacter Pylori Infection

Additional Keywords : Drug-Plant-Vitamin Synergies

[+]

The methylsulfonylmethane study product provided significant relief of allergic rhinitis symptoms.Nov 28, 2018

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Pubmed Data : JMIR Res Protoc. 2018 Nov 29 ;7(11):e11139. Epub 2018 Nov 29. PMID: 30497995

Article Published Date : Nov 28, 2018

Study Type : Human Study

Additional Links

Substances : MSM (Methylsulfonylmethane)

Diseases : Allergic Rhinitis

Pharmacological Actions : Anti-Allergic Agents

[+]

The results of this study found that dosing twice a day may be important for increasing or prolonging certain chemopreventive benefits associated with sulforaphane consumption.Feb 28, 2015

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Pubmed Data : Mol Nutr Food Res. 2015 Mar ;59(3):424-33. Epub 2015 Jan 22. PMID: 25522265

Article Published Date : Feb 28, 2015

Study Type : Human Study

Additional Links

Substances : Cruciferous Vegetables, Sulforaphane

Diseases : Cancers: All

Pharmacological Actions : Chemopreventive

Additional Keywords : Absorption, Bioavailability, Dietary Modification

[+]

Theanine/cysteine intake suppresses exercise-induced neutrophilia and lymphopenia in athletes.Jan 01, 2010

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Pubmed Data : J Int Soc Sports Nutr. 2010;7(1):23. Epub 2010 Jun 4. PMID: 20525371

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Substances : Cysteine (see N-Acetylcysteine), Theanine

Diseases : Athletic Performance, Athletic Performance: Recovery , Lymphopenia, Neutrophils: Elevated

[+]

Click here to read the entire abstract

Pubmed Data : Free Radic Biol Med. 2018 08 20 ;124:532-540. Epub 2018 Jun 30. PMID: 29969714

Article Published Date : Jan 20, 2018

Study Type : Human In Vitro

Additional Links

Substances : Sulforaphane

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidant Effects, Nrf2 activation

Additional Keywords : Antioxidants, Broccoli, Broccoli Sprouts, Cruciferous Vegetables

[+]

[+]

Sulforaphane decreases leukemia cell viability in vitro by inhibiting NADPH oxidase enzymes and redox transporter signaling.Jan 01, 2018

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Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:4125297. Epub 2018 Nov 18. PMID: 30581529

Article Published Date : Jan 01, 2018

Study Type : Human In Vitro

Additional Links

Substances : Cruciferous Vegetables, Sulforaphane

Diseases : Leukemia

Pharmacological Actions : Antioxidant, Antioxidant Effects, Antiproliferative , NADPH Oxidase Inhibitors

Additional Keywords : Broccoli, Broccoli Sprouts, Isothiocyanates

[+]

Sulforaphane delays fibroblast aging in vitro by decreasing glycolysis and reducing oxidative stress.Jan 01, 2018

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Pubmed Data : Phytomedicine. 2023 Apr ;112:154705. Epub 2023 Feb 9. PMID: 36796188

Article Published Date : Mar 31, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Organosulfur Compounds

Diseases : Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation

[+]

In silico and in vitro analysis of sulforaphane anti-candida activity. Dec 18, 2022

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Pubmed Data : Antibiotics (Basel). 2022 Dec 19 ;11(12). Epub 2022 Dec 19. PMID: 36551499

Article Published Date : Dec 18, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Candida Albicans

Pharmacological Actions : Antifungal Agents, Antimicrobial

Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation

[+]

Lipid-based nanoparticle formulation of diallyl trisulfide chemosensitizes the growth inhibitory activity of doxorubicin in colorectal cancer.Mar 27, 2022

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Pubmed Data : Molecules. 2022 Mar 28 ;27(7). Epub 2022 Mar 28. PMID: 35408590

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Pubmed Data : Curr Pharm Des. 2012 Aug 23. Epub 2012 Aug 23. PMID: 22950492

Article Published Date : Aug 22, 2012

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Aspirin-Induced Toxicity , NSAID-induced toxicity

[+]

Acetaminophen-induced liver injury: Molecular mechanism and treatments from natural products.Dec 31, 2022

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Pubmed Data : Front Pharmacol. 2023 ;14:1122632. Epub 2023 Mar 27. PMID: 37050900

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Polyphenols, Sulforaphane

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen

[+]

Addition of bromelain and acetylcysteine to gemcitabine potentiates tumor inhibition in vivo in human colon cancer cell line LS174T.Dec 31, 2020

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Pubmed Data : Am J Cancer Res. 2021 ;11(5):2252-2263. Epub 2021 May 15. PMID: 34094682

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Pubmed Data : J Biol Inorg Chem. 2021 May 22. Epub 2021 May 22. PMID: 34023945

Article Published Date : May 21, 2021

Study Type : Animal Study

Additional Links

Substances : Allicin

Diseases : Aluminum Toxicity , Cognitive Decline/Dysfunction, Copper Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

[+]

Allicin ameliorates cognitive impairment in APP/PS1 mice.Jan 31, 2018

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Pubmed Data : Tissue Cell. 2018 Feb ;50:89-95. Epub 2017 Dec 2. PMID: 29429523

Article Published Date : Jan 31, 2018

Study Type : Transgenic Animal Study

Additional Links

Substances : Allicin

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Allicin ameliorates renal ischemia/reperfusion injury via inhibition of oxidative stress and inflammation.Aug 22, 2021

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Pubmed Data : Life Sci. 2022 May 21 ;302:120656. Epub 2022 May 21. PMID: 35605695

Article Published Date : May 20, 2022

Study Type : Animal Study

Additional Links

Substances : Allicin

Diseases : Chemotherapy and Radiation Toxicity

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective

[+]

Allicin could be used as a pharmacologic treatment in tunicamycin induced cognitive deficits.May 31, 2017

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Pubmed Data : Iran J Basic Med Sci. 2017 Jun ;20(6):676-682. PMID: 28868122

Article Published Date : May 31, 2017

Study Type : Animal Study

Additional Links

Substances : Allicin

Diseases : Antibiotic Toxicity

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Antibiotics

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Allicin could be used in protection in traumatic spinal cord injury.Sep 30, 2016

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Pubmed Data : Nutrients. 2019 Dec 2 ;11(12). Epub 2019 Dec 2. PMID: 31810206

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Pubmed Data : iScience. 2020 May 22 ;23(5):101113. Epub 2020 Apr 28. PMID: 32413611

Article Published Date : May 21, 2020

Study Type : Animal Study

Additional Links

Substances : Allicin

Diseases : Hepatic Steatosis, Obesity

Pharmacological Actions : Hepatoprotective

Additional Keywords : Anti-Obesity Agents

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Allicin is highly effective in the treatment and prevention of acrylamide-induced intestinal injury.Oct 24, 2021

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Pubmed Data : J Agric Food Chem. 2021 Oct 25. Epub 2021 Oct 25. PMID: 34694121

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Pubmed Data : Environ Toxicol Pharmacol. 2019 Nov 23 ;74:103306. Epub 2019 Nov 23. PMID: 31812117

Article Published Date : Nov 22, 2019

Study Type : Animal Study

Additional Links

Substances : Allicin

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Diclofenac

[+]

Allicin promotes functional recovery in ischemic stroke.Sep 05, 2023

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Allicin regulates Treg/Th17 balance in mice with collagen-induced arthritis.Apr 30, 2021

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Pubmed Data : FASEB J. 2020 Jul 3. Epub 2020 Jul 3. PMID: 32619085

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Pubmed Data : Vascular. 2021 Jul 23:17085381211035291. Epub 2021 Jul 23. PMID: 34301159

Article Published Date : Jul 22, 2021

Study Type : Animal Study

Additional Links

Substances : Allicin

Diseases : Vascular Calcification

Pharmacological Actions : Vasoprotective

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Ameliorative role of diallyl disulfide against glycerol-induced nephrotoxicity.Dec 31, 2020

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Pubmed Data : J Pharm Bioallied Sci. 2021 Jan-Mar;13(1):129-135. Epub 2020 Dec 21. PMID: 34084059

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Garlic, Organosulfur Compounds

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Renoprotective

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Anti-gastric cancer effects of Z Ajoene and its molecular mechanisms.Aug 31, 2021

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Pubmed Data : Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2021 Sep ;37(5):514-519. PMID: 34816664

Article Published Date : Aug 31, 2021

Study Type : Animal Study

Additional Links

Substances : Organosulfur Compounds

Diseases : Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

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Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.Sep 28, 2006

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Pubmed Data : Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID: 16386831

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Pubmed Data : J Agric Food Chem. 2018 Jun 6 ;66(22):5574-5580. Epub 2018 May 23. PMID: 29730925

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Pubmed Data : Free Radic Biol Med. 2015 May 26. Epub 2015 May 26. PMID: 26025579

Article Published Date : May 25, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress

Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents, Nrf2 activation

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Co-treatment with vitamin E, sulphoraphane and Ficus religiosa were found to be effective in reversing cadmium induced reproductive toxicity.Jul 31, 2014

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Pubmed Data : Syst Biol Reprod Med. 2014 Aug ;60(4):199-205. Epub 2014 Apr 23. PMID: 24758558

Pubmed Data : Inflammation. 2021 Aug ;44(4):1381-1395. Epub 2021 Jan 29. PMID: 33511484

Article Published Date : Jul 31, 2021

Study Type : Animal Study

Additional Links

Substances : Garlic, Organosulfur Compounds

Diseases : Brain Inflammation , Depression, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Antioxidants

[+]

Diallyl disulfide alleviates hypercholesterolemia induced by a western diet.May 02, 2023

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Pubmed Data : J Cell Mol Med. 2019 01 ;23(1):194-204. Epub 2018 Nov 5. PMID: 30394654

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Garlic, Organosulfur Compounds

Diseases : Leukemia: Acute myelogenous leukemia (AML)

Pharmacological Actions : Antiproliferative

[+]

Diallyl disulfide may be a potential therapeutic candidate for the treatment of rheumatoid arthritis.Dec 31, 2017

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Pubmed Data : J Environ Pathol Toxicol Oncol. 2018 ;37(4):291-303. PMID: 30806236

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Garlic, Organosulfur Compounds

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Freund adjuvant

[+]

Diallyl disulfide mitigates DNA damage and spleen tissue effects after irradiation.Nov 23, 2019

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Pubmed Data : Life Sci. 2021 Aug 1 ;278:119631. Epub 2021 May 19. PMID: 34022202

Article Published Date : Jul 31, 2021

Study Type : Animal Study

Additional Links

Substances : Organosulfur Compounds

Diseases : Inflammation, Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Concanavalin A

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Pubmed Data : Antioxidants (Basel). 2021 Dec 11 ;10(12). Epub 2021 Dec 11. PMID: 34943080

Article Published Date : Dec 10, 2021

Study Type : Animal Study

Additional Links

Substances : Organosulfur Compounds

Diseases : Chronic Pain, Inflammation

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Antioxidants, Nrf2 activation

Additional Keywords : Natural Substance/Drug Synergy

[+]

Hypertensive vascular and cardiac remodeling protection by allicin in spontaneous hypertension rats via CaMK Ⅱ/NF-κB pathway.Oct 31, 2022

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Methylsulfonylmethane and tamoxifen synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts.Jun 18, 2015

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Pubmed Data : BMC Cancer. 2015 Jun 19 ;15:474. Epub 2015 Jun 19. PMID: 26084564

Article Published Date : Jun 18, 2015

Study Type : Animal Study

Additional Links

Substances : MSM (Methylsulfonylmethane)

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative

Additional Keywords : Synergy with Tamoxifen

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Methylsulfonylmethane increases the alveolar bone density of mandibles in aging female mice.Dec 31, 2020

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Pubmed Data : Front Physiol. 2021 ;12:708905. Epub 2021 Oct 4. PMID: 34671266

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Pubmed Data : Iran J Basic Med Sci. 2013 Aug ;16(8):896-900. PMID: 24106592

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Pubmed Data : World J Hepatol. 2014 Feb 27 ;6(2):98-106. PMID: 24575169

Article Published Date : Feb 26, 2014

Study Type : Animal Study

Additional Links

Substances : MSM (Methylsulfonylmethane)

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic, Chemopreventive

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MSM has therapeutic value in an animal model of colitis. Jun 15, 2011

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Pubmed Data : Toxicol Appl Pharmacol. 2011 Jun 15 ;253(3):197-202. Epub 2011 Apr 2. PMID: 21463646

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Pubmed Data : Dis Markers. 2018 ;2018:5046372. Epub 2018 Jan 30. PMID: 29651324

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Cysteine (see N-Acetylcysteine)

Diseases : Asphyxia

Pharmacological Actions : Antioxidants

[+]

N-acetylcysteine and thymoquinone have renoprotective effects of against the toxicity of fluoride via multiple mechanisms.Dec 31, 2017

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Pubmed Data : J Agric Food Chem. 2022 May 18 ;70(19):5829-5837. Epub 2022 May 6. PMID: 35522133

Article Published Date : May 17, 2022

Study Type : Animal Study

Additional Links

Substances : Garlic, Organosulfur Compounds

Diseases : Metabolic Diseases

Pharmacological Actions : Gastrointestinal Agents

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Obesity may increase susceptibility to chronic pain often due to poor diet.Dec 31, 2017

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Pubmed Data : J Surg Res. 2016 Jun 15 ;203(2):348-59. Epub 2016 Mar 24. PMID: 27363643

Article Published Date : Jun 14, 2016

Study Type : Animal Study

Additional Links

Substances : Sulforaphane, Thymoquinone

Diseases : Gastric Ulcer

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Anti-Ulcer Agents, Antioxidants, Gastroprotective

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Profile of insulin resistance in adipose tissue of diet induced obese mice in response to anti-obesity treatment.Apr 30, 2022

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Pubmed Data : FASEB J. 2022 May ;36 Suppl 1. PMID: 35559539

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The Following are Sub-Topics of Organosulfur Compounds

View the Evidence: 938 Abstracts with Organosulfur Compounds Research

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Sulforaphane ameliorates lipid profile.Apr 07, 2021

Sulforaphane exhibits potent renoprotective effects in preclinical models of kidney diseases.May 31, 2023

Allicin as an add-on therapy improves H. pylori eradication, healing of ulcers, and remission of symptoms.Oct 20, 2019

Sulforaphane and EGCG restore estrogen receptor expression by modulating epigenetic events in the breast cancer cell line MDA-MB-231.Oct 17, 2017

In vitro effects of sulforaphane on interferon-driven inflammation and exploratory evaluation in two healthy volunteers.Jun 11, 2021

Accumulation of sulforaphane and alliin in human prostate tissue. Aug 09, 2022

Acetylcysteine is beneficial in treating idiopathic pulmonary fibrosis. - Article 2Sep 01, 1995

After 4 weeks consuming broccoli sprouts powder it resulted in a significant decrease in serum insulin concentration in patients. Oct 31, 2012

Allicin extract and sodium bicarbonate may be suitable as drug alternatives in prevention of thrush in newborn infants. Jan 01, 1992

Allicin improves carotid artery intima-media thickness in coronary artery disease patients with hyperhomocysteinemia.Jul 31, 2017

Broccoli sprout homogenate is safe in stable SCD patients and may induce changes in gene expression levels.Dec 31, 2015

Broccoli sprouts may enhance detoxication of airborne pollutants and attenuate their associated health risks.Dec 31, 2011

Broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Apr 01, 2009

Consumption of broccoli sprouts modulated the excretion of biomarkers linked to inflammation and vascular reactions.Apr 14, 2015

Cystine (a dipeptide of cysteine) and theanine supplementation restores high-Intensity resistance exercise-induced atenuation of natural killer cell activity in well-trained men.Feb 09, 2010

Daily administration of free sulforaphane shows promise in managing biochemical recurrences in prostate cancer after radical prostatectomy.May 11, 2015

Effect of a sulforaphane supplement on muscle soreness and damage induced by eccentric exercise.Jan 11, 2021

Effect of supplemental antioxidant-based therapy on the oxidative stress level in COVID-19 patients.Feb 28, 2023

Effects of sulforaphane intake on processing speed and negative moods in healthy older adults.Dec 31, 2021

Efficacy of N-acetylcysteine, D-mannose and Morinda citrifolia to treat recurrent cystitis in breast cancer survivors. Aug 31, 2017

Efficacy of sulforaphane in treatment of children with autism spectrum disorder.Nov 23, 2022

Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients.Apr 23, 2018

Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli.Dec 31, 2017

L-cystine and l-theanine may contribute to enhancing the immune response against the H1N1 virus. Dec 01, 2008

Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritisFeb 29, 2016

Methylsulfonylmethane appears to dampen the release of inflammatory molecules in response to exercise.Dec 31, 2015

Methylsulfonylmethane may favourably influence selected markers of exercise recovery.Sep 26, 2012

MSM contributes to the improvement of the symptoms of rosacea.Mar 01, 2008

MSM improves symptoms of pain and physical function in those with osteoarthritis.Mar 01, 2006

MSM relieves symptoms in the treatment of seasonal allergic rhinitis.Apr 01, 2002

MSM supplementation has therapeutic value in osteoarthritis. Jan 01, 2011

N-acetyl cysteine appears to be a safe and moderately effective augmentation strategy in chronic schizophrenia.Sep 01, 2008

N-acetylcysteine could be associated with a reduction in depressive symptoms.Dec 03, 2018

Optimized curcumin, pomegranate extract, and methylsulfonylmethane reduce acute, systemic inflammatory response to a half-marathon race. Jun 30, 2020

Oral chronic sulforaphane effects on heavy resistance exercise.Sep 30, 2021

Oral sulforaphane safely and effectively induces mucosal Phase II enzyme expression in the upper airway of human subjects. Mar 01, 2009

Oral supplementation of MSM has alleviating effects on known markers of oxidative stress following acute bouts of exercise in healthy young men.Oct 01, 2011

Polyphenol and methylsulfonylmethane supplementation improves immune, DAMP signaling, and inflammatory responses during recovery from all-out running efforts.Dec 31, 2020

Raw broccoli results in faster absorption, higher bioavailability, and higher peak plasma amounts of sulforaphane, compared to cooked broccoli.Nov 26, 2008

Safety Study: Brocolli sprouts (sulforaphane) are safe, tolerable and do not adversely effect thyroid hormone levels.Jan 01, 2006

Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder.Apr 28, 2020

Sulforaphane detoxifies benzene, an air pollutant, in a dose-dependent manner and may attentuate attenuate associated long-term health risks of air pollution. Jul 03, 2019

Sulforaphane from broccoli was able to reduce some of the symptoms of autism.Dec 31, 2016

Sulforaphane has a novel chemopreventive mechanism in human colon cancer cells and prostate epithelial cells, namely the inhibition of histone deacetylase (HDAC). IFeb 01, 2007

Sulforaphane may improve endothelial function and blood pressure in women with pregnancy hypertension.Apr 30, 2021

Sulforaphane promotes white matter plasticity and improves long-term neurological outcomes after ischemic stroke.Nov 19, 2022

Sulforaphane protects against chemically-induced damage in bladder cells and tissues. Jan 01, 2003

Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.Dec 31, 2014

Sulforaphane-containing broccoli sprout extracts induce a cytoprotective phase 2 response in mouse and human skin.Apr 01, 2007

Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles.Dec 31, 2013

Sulforaphane’s capacity to activate the Keap1–Nrf2 cytoprotective signaling pathway, and may protect against environmental and endogenous risk factors in autism spectrum disorders.Oct 27, 2014

Supplementation therapy of sulforaphane rich broccoli sprout extract may have the potential to improve cognitive deficits in patients with schizophrenia. Apr 29, 2015

Supplementation with sulforaphane rich broccoli sprout extract could improve liver function through reduction of oxidative stress.Nov 20, 2015

Synergism of allicin in combination with itraconazole and terbinafine, which could be a reference for the treatment of tinea capitis due to M. canis.Dec 31, 2020

The bioavailability of isothiocyanates from fresh broccoli is approximately three times greater than that from cooked broccoli,Jan 01, 2000

The bioavailability of sulforaphane from glucoraphanin supplements was equal to that from broccoli sprouts.Dec 31, 2014

The effect of daily methylsulfonylmethane (MSM) consumption on high-density lipoprotein cholesterol.Oct 14, 2021

The garlic compound allicin improves Helicobacter pylori eradication outcomes in patients who are HP positive in biopsy. Jan 01, 2001

The methylsulfonylmethane study product provided significant relief of allergic rhinitis symptoms.Nov 28, 2018

The results of this study found that dosing twice a day may be important for increasing or prolonging certain chemopreventive benefits associated with sulforaphane consumption.Feb 28, 2015

Theanine/cysteine intake suppresses exercise-induced neutrophilia and lymphopenia in athletes.Jan 01, 2010

This data suggest the therapeutic effect of allicin (L-cysteine) on COVID-19.Jun 17, 2021

Week-long oral administration of sulforaphane increased blood and thalamic glutathione levels in healthy human subjects.May 01, 2018

A diet rich in sulforaphane and related mustard oils may be considered as a supportive nutritional strategy to enhance therapeutic efficacy in patients suffering from pancreatic cancer.Mar 29, 2014

Combination of epigallocatechin gallate and sulforaphane dounteracts In Vitro oxidative stress and delays stemness loss of amniotic fluid stem cells.Jan 01, 2018

Free radicals enhance the activation of Antioxidant Response Element (ARE) by sulforaphane, despite suppression of Nrf2 nuclear accumulation.Jan 20, 2018

Methylsulfonylmethane and mobilee prevent negative effect of IL-1β in human chondrocyte cultures.Nov 30, 2018

Protective role of allicin and L-ascorbic acid against the genotoxic damage induced by chlormadinone acetate.Aug 31, 2005

Sulforaphane attentuates cadmium-induced carcinogenesis through Nrf2, antioxidant, and autophagy mechanisms.Jan 15, 2018

Sulforaphane combats colon cancer in vitro by inhibiting COX-2 and prostaglandin E1 synthase and exhibiting anti-angiogenic, anti-proliferative, and anti-metastatic properties.Jan 01, 2018

Sulforaphane decreases leukemia cell viability in vitro by inhibiting NADPH oxidase enzymes and redox transporter signaling.Jan 01, 2018

Sulforaphane delays fibroblast aging in vitro by decreasing glycolysis and reducing oxidative stress.Jan 01, 2018

Organosulfur Compounds

View the Evidence:
938 Abstracts with Organosulfur Compounds Research