P-Coumaric Acid

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58 Diseases Researched for P-Coumaric Acid
NameACCKFocus
Oxidative Stress1017Locked
Lipid Peroxidation510Locked
Arthritis48Locked
Chemotherapy-Induced Toxicity: Doxorubicin58Locked
Inflammation47Locked
Lipopolysaccharide-Induced Toxicity47Locked
Colon Cancer45Locked
Myocardial Infarction35Locked
Brain Inflammation 24Locked
Diabetes Mellitus: Type 224Locked
Hyperlipidemia23Locked
Acetaminophen (Tylenol) Toxicity 12Locked
Alcohol Toxicity 12Locked
Alcoholic Liver Disease12Locked
Anxiety12Locked
Atopic Dermatitis12Locked
Brain Hypoxia12Locked
Brain: Oxidative Stress12Locked
Cadmium Poisoning 12Locked
Cancers: All12Locked
Cerebral Ischemia12Locked
Cholesterol: Oxidation12Locked
DNA damage12Locked
Depression12Locked
Diabetes: Cognitive Dysfunction12Locked
Diabetic Complications12Locked
Diabetic Nephropathy12Locked
Dyslipidemias12Locked
Erectile Dysfunction12Locked
Hypoglycemia12Locked
Ischemia12Locked
Kidney Damage12Locked
Kidney Damage: Chemically-Induced12Locked
Lung Inflammation12Locked
Lung Injury: Smoke-Induced12Locked
Memory Disorders: Drug-Induced12Locked
Periodontal Diseases12Locked
Rheumatoid Arthritis12Locked
Alzheimer's Disease11Locked
Cardiomegaly11Locked
Cataract11Locked
Chronic Obstructive Pulmonary Disease11Locked
Colorectal Cancer11Locked
Coronavirus Infection11Locked
Escherichia coli Infections11Locked
Hyperglycemia11Locked
Listeria Infections11Locked
Lung Cancer11Locked
Lung Injury: Acute11Locked
Melanoma11Locked
Neuroblastoma11Locked
Obesity11Locked
Osteoarthritis11Locked
Pseudomonas aeruginosa11Locked
Radiation11Locked
Skin Cancer11Locked
Squamous cell carcinoma11Locked
Ulcerative Colitis11Locked
47 Pharmacological Actions Researched for P-Coumaric Acid
NameACCKFocus
Antioxidants2443Locked
Anti-Inflammatory Agents2238Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor1120Locked
Interleukin-6 Downregulation611Locked
Neuroprotective Agents611Locked
Cardioprotective69Locked
Anti-Apoptotic58Locked
Nrf2 activation58Locked
Antiproliferative 66Locked
Chemoprotective Agents46Locked
Interleukin-1 beta downregulation46Locked
Apoptotic44Locked
Chemopreventive24Locked
Cyclooxygenase 2 Inhibitors34Locked
Malondialdehyde Down-regulation24Locked
Renoprotective24Locked
Hypoglycemic Agents23Locked
Hypolipidemic23Locked
Adiponectin upregulation12Locked
Anti-Angiogenic12Locked
Anti-Anxiety Agents12Locked
Anticholesteremic Agents12Locked
Antidepressive Agents12Locked
Brain-derived neurotrophic factor modulator12Locked
Catalase Up-Regulation12Locked
Chondroprotective12Locked
Enzyme Inhibitors12Locked
Glucose transporter-2 (GLUT2) expression down-regulation12Locked
Hepatoprotective12Locked
Immunomodulatory12Locked
Interleukin-4 downregulation12Locked
Prophylactic Agents12Locked
Superoxide Dismutase Up-regulation12Locked
Transforming growth factor beta (TGF-β) inhibitor12Locked
Anti-Bacterial Agents11Locked
Anti-metastatic11Locked
Antimicrobial11Locked
Antineoplastic Agents11Locked
Antiviral Agents11Locked
Cell cycle arrest11Locked
Glutathione Upregulation 11Locked
Heme oxygenase-1 up-regulation11Locked
NF-kappaB Inhibitor11Locked
Postaglandin PGE2 downregulation 11Locked
Quorum Sensing Inhibition11Locked
Radioprotective11Locked
Tumor Suppressor Protein p53 Upregulation11Locked

View the Evidence:
56 Abstracts with P-Coumaric Acid Research

[+]

Antiangiogenic effects of p-coumaric acid in human endothelial cells.Feb 28, 2013

Pubmed Data : Phytother Res. 2013 Mar ;27(3):317-23. Epub 2012 May 14. PMID: 22585412
Article Published Date : Feb 28, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Cancers: All
Pharmacological Actions : Anti-Angiogenic, Chemopreventive
[+]

Antidiabetic and antihyperlipidemic activity of p-coumaric acid in diabetic rats, role of pancreatic GLUT 2.Nov 30, 2016

Pubmed Data : Biomed Pharmacother. 2016 Dec ;84:230-236. Epub 2016 Sep 20. PMID: 27662473
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Hypoglycemia
Pharmacological Actions : Glucose transporter-2 (GLUT2) expression down-regulation, Hypoglycemic Agents
[+]

Antioxidant effect of p-coumaric acid on interleukin 1-β and tumor necrosis factor-α in rats with renal ischemic reperfusion.Dec 27, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nefrologia. 2019 Dec 28. Epub 2019 Dec 28. PMID: 31892486
Article Published Date : Dec 27, 2019
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Ischemia, Kidney Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Gallic acid and p-coumaric acid attenuate type 2 diabetes-induced neurodegeneration.Dec 31, 2016

Pubmed Data : Metab Brain Dis. 2017 08 ;32(4):1279-1286. Epub 2017 Jun 2. PMID: 28573601
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Gallic Acid, P-Coumaric Acid
Diseases : Diabetes: Cognitive Dysfunction, Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Gallic acid and p-coumaric acid exhibited marked anti-diabetic action.Aug 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Sep ;105:1091-1097. Epub 2018 Jun 20. PMID: 30021345
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : Gallic Acid, P-Coumaric Acid
Diseases : Diabetes Mellitus: Type 2, Dyslipidemias
Pharmacological Actions : Adiponectin upregulation, Anti-Inflammatory Agents, Hypolipidemic, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Involvement of NLRP3 inflammasome pathway in the protective mechanisms of ferulic acid and p-coumaric acid in LPS-induced sickness behavior and neuroinflammation.Sep 26, 2023

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2023 Sep 27. Epub 2023 Sep 27. PMID: 37755515
Article Published Date : Sep 26, 2023
Study Type : Animal Study
Additional Links
Substances : Ferulic acid, P-Coumaric Acid
Diseases : Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Neuroprotective effect of p-coumaric acid in mice with cerebral ischemia reperfusion injuries.May 31, 2018

Pubmed Data : Metab Brain Dis. 2018 Jun ;33(3):765-773. Epub 2018 Jan 17. PMID: 29344828
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Cerebral Ischemia
Pharmacological Actions : Neuroprotective Agents
[+]

Oral administration of p-coumaric acid for 30 days significantly inhibited LDL oxidation.Sep 30, 2000

Pubmed Data : Am J Physiol Cell Physiol. 2000 Oct ;279(4):C954-60. PMID: 11003575
Article Published Date : Sep 30, 2000
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Cholesterol: Oxidation
Pharmacological Actions : Anticholesteremic Agents, Antioxidants
[+]

Oral administration of p-coumaric acid significantly protected against cadmium-induced nephrotoxicity.Feb 28, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ren Fail. 2014 Mar ;36(2):244-51. Epub 2013 Sep 24. PMID: 24060003
Article Published Date : Feb 28, 2014
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Cadmium Poisoning , Kidney Damage: Chemically-Induced, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Renoprotective
Problem Substances : Cadmium
[+]

Oral supplementation with p-coumaric acid protects mice against diabetes-associated spontaneous destruction of periodontal tissue.Nov 30, 2019

Pubmed Data : J Periodontal Res. 2019 Dec ;54(6):690-701. Epub 2019 Jul 21. PMID: 31328274
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Diabetic Complications, Periodontal Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

p-Coumaric acid activates the GABA-A receptor in vitro and is orally anxiolytic in vivo.Jan 31, 2014

Pubmed Data : Phytother Res. 2014 Feb ;28(2):207-11. Epub 2013 Mar 26. PMID: 23533066
Article Published Date : Jan 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Anxiety
Pharmacological Actions : Anti-Anxiety Agents
Additional Keywords : Natural Substances Versus Drugs
[+]

P-Coumaric acid alleviates experimental diabetic nephropathy.Nov 30, 2019

Pubmed Data : Life Sci. 2019 Dec 1 ;238:116965. Epub 2019 Oct 17. PMID: 31629762
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Renoprotective, Transforming growth factor beta (TGF-β) inhibitor
[+]

p-coumaric acid ameliolates atopic dermatitis-like skin lesions.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ginseng Res. 2021 Jan ;45(1):176-182. Epub 2020 Jul 5. PMID: 33437169
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Atopic Dermatitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-4 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

p-Coumaric acid attenuates alcohol exposed hepatic injury through MAPKs, apoptosis and Nrf2 signaling in experimental models.Apr 24, 2020

Pubmed Data : Chem Biol Interact. 2020 Apr 25 ;321:109044. Epub 2020 Mar 7. PMID: 32151596
Article Published Date : Apr 24, 2020
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Alcohol Toxicity , Alcoholic Liver Disease, Lipid Peroxidation
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, Nrf2 activation
[+]

P-coumaric acid attenuates lipopolysaccharide-induced lung inflammation.Nov 30, 2019

Pubmed Data : Inflammation. 2019 Dec ;42(6):1939-1950. PMID: 31267276
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

p-coumaric acid could be considered a potential immunosuppressive agent in treating autoimmune inflammatory diseases like rheumatoid arthritis.Jan 31, 2013

Pubmed Data : Inflammation. 2013 Feb ;36(1):169-76. PMID: 22923003
Article Published Date : Jan 31, 2013
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Immunomodulatory, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

p-Coumaric acid enhances long-term potentiation and recovers scopolamine-induced learning and memory impairments.Jan 20, 2017

Pubmed Data : Biochem Biophys Res Commun. 2017 10 21 ;492(3):493-499. Epub 2017 Aug 19. PMID: 28830814
Article Published Date : Jan 20, 2017
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Memory Disorders: Drug-Induced
Pharmacological Actions : Neuroprotective Agents
[+]

P-coumaric acid has anti-inflammatory effects in an arthritis model.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:5198594. Epub 2018 Feb 22. PMID: 29681976
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

P-coumaric acid is capable of causing inhibitory effects on the activities of enzymes, associated with oxidative stress-induced erectile dysfunction.Jun 30, 2019

Pubmed Data : Andrologia. 2019 Jul ;51(6):e13281. Epub 2019 Apr 14. PMID: 30983021
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Erectile Dysfunction, Oxidative Stress
Pharmacological Actions : Antioxidants, Enzyme Inhibitors
[+]

p-coumaric acid protected the myocardial infarcted rat's heart against apoptosis by inhibiting oxidative stress.Oct 08, 2013

Pubmed Data : Int J Cardiol. 2013 Oct 9 ;168(4):3259-66. Epub 2013 May 16. PMID: 23684599
Article Published Date : Oct 08, 2013
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Myocardial Infarction, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective
Problem Substances : Isoproterenol
[+]

p-Coumaric acid protects cardiac function against lipopolysaccharide-induced acute lung injury by attenuation of oxidative stress.Jul 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2019 Aug ;22(8):949-955. PMID: 31579452
Article Published Date : Jul 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Lipopolysaccharide-Induced Toxicity, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

p-coumaric acid suppresses cigarette smoke-induced pulmonary inflammation.Dec 31, 2017

Pubmed Data : Am J Chin Med. 2018 ;46(2):407-421. Epub 2018 Feb 12. PMID: 29433391
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Inflammation, Lung Injury: Smoke-Induced
Pharmacological Actions : Anti-Inflammatory Agents
[+]

P-coumaric acid, a dietary polyphenol ameliorates inflammation and curtails cartilage and bone erosion in the rheumatoid arthritis rat model.Sep 09, 2017

Pubmed Data : Biofactors. 2017 Sep 10 ;43(5):698-717. Epub 2017 Jul 25. PMID: 28742266
Article Published Date : Sep 09, 2017
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Arthritis, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective
[+]

p-coumaric protects rats hearts against doxorubicin-induced oxidative stress.Oct 31, 2003

Pubmed Data : Pharmacol Res. 2003 Nov ;48(5):461-5. PMID: 12967591
Article Published Date : Oct 31, 2003
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents, Malondialdehyde Down-regulation
[+]

Preventive effects of p-coumaric acid on lysosomal dysfunction and myocardial infarct size in experimentally induced myocardial infarction.Jan 14, 2013

Pubmed Data : Eur J Pharmacol. 2013 Jan 15 ;699(1-3):33-9. Epub 2012 Nov 22. PMID: 23178520
Article Published Date : Jan 14, 2013
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Lipid Peroxidation, Myocardial Infarction
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Prophylactic effect and mechanism of p-coumaric acid against hypoxic cerebral edema in mice.Dec 31, 2018

Pubmed Data : Respir Physiol Neurobiol. 2019 02 ;260:95-104. Epub 2018 Nov 14. PMID: 30447305
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Brain: Oxidative Stress, Brain Hypoxia, Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents, Prophylactic Agents
[+]

Protective effects of p-coumaric acid against acetaminophen-induced hepatotoxicity.Oct 31, 2018

Pubmed Data : Food Chem Toxicol. 2018 Nov ;121:131-139. Epub 2018 Aug 24. PMID: 30149109
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Acetaminophen (Tylenol) Toxicity , DNA damage, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants
Problem Substances : Acetaminophen, Paracetamol
[+]

Protective effects of p-coumaric acid against oxidant and hyperlipidemia.Feb 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Mar ;111:579-587. Epub 2018 Dec 31. PMID: 30599319
Article Published Date : Feb 28, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Hyperlipidemia, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Results describe a protective effect of P-coumaric acid against doxorubicin-induced nephrotoxicity.Dec 31, 2019

Pubmed Data : Arch Med Res. 2020 01 ;51(1):32-40. Epub 2020 Feb 18. PMID: 32086107
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Inflammation, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Chemoprotective Agents, Interleukin-1 beta downregulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Supplementation of p-coumaric acid exhibits chemopreventive effect via induction of Nrf2 in a short-term preclinical model of colon cancer.Oct 31, 2019

Pubmed Data : Eur J Cancer Prev. 2019 Nov ;28(6):472-482. PMID: 30407216
Article Published Date : Oct 31, 2019
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Colon Cancer
Pharmacological Actions : Antioxidants, Chemopreventive, Nrf2 activation
[+]

The present study clearly demonstrates the anti-inflammatory potential of the p-coumaric acid against adjuvant-induced arthritis.Jan 31, 2013

Pubmed Data : Rheumatol Int. 2013 Feb ;33(2):325-34. Epub 2012 Mar 25. PMID: 22447332
Article Published Date : Jan 31, 2013
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

These findings suggest the potential use of p-coumaric acid as a preventive and therapeutic medicine for depression.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Neurobiol. 2018 Jun ;27(3):189-199. Epub 2018 Jun 30. PMID: 30022870
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Depression, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Brain-derived neurotrophic factor modulator, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Antiproliferative effect of p-Coumaric acid targets UPR activation by downregulating Grp78 in colon cancer.Jul 31, 2018

Pubmed Data : Chem Biol Interact. 2018 Aug 1 ;291:16-28. Epub 2018 Jun 5. PMID: 29879413
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation
[+]

Caffeic, coumaric and ferulic acids may participate as active ingredients in anticancer agents against lung and colon cancer development, at adhesion and migration steps of tumor progression.Sep 29, 2015

Pubmed Data : Eur J Pharmacol. 2015 Sep 30. Epub 2015 Sep 30. PMID: 26432689
Article Published Date : Sep 29, 2015
Study Type : In Vitro Study
Additional Links
Substances : Caffeic Acid, Ferulic acid, P-Coumaric Acid
Diseases : Colon Cancer, Lung Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

Drug-induced anti-inflammatory response in A549 cells, as detected by Raman spectroscopy: a comparative analysis of the actions of dexamethasone and p-coumaric acid.Feb 24, 2019

Pubmed Data : Analyst. 2019 Feb 25 ;144(5):1622-1631. PMID: 30633254
Article Published Date : Feb 24, 2019
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Chronic Obstructive Pulmonary Disease, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Ferulic acid and p-coumaric acid inhibit colorectal cancer cell proliferation. Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2016 ;17(8):4019-23. PMID: 27644655
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Ferulic acid, P-Coumaric Acid
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative
[+]

In silico screening of potent bioactive compounds from honeybee products against COVID-19 target enzymes.May 01, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Sci Pollut Res Int. 2021 May 2. Epub 2021 May 2. PMID: 33934306
Article Published Date : May 01, 2021
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid, Honey, Kaempferol, P-Coumaric Acid, Quercetin
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

In vitro evaluation of p-coumaric acid and naringin combination in human epidermoid carcinoma cell line.Nov 28, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Oncol. 2023 Nov 29 ;41(1):4. Epub 2023 Nov 29. PMID: 38019336
Article Published Date : Nov 28, 2023
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin, P-Coumaric Acid
Diseases : Skin Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Local administration of p-coumaric acid decreases lipopolysaccharide-induced acute lung injury.Feb 05, 2021

Pubmed Data : Eur J Pharmacol. 2021 Feb 6 ;897:173929. Epub 2021 Feb 6. PMID: 33561444
Article Published Date : Feb 05, 2021
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Low-level laser irradiation potentiates anticancer activity of p-coumaric acid against human malignant melanoma cells.Mar 05, 2019

Pubmed Data : Melanoma Res. 2019 Mar 6. Epub 2019 Mar 6. PMID: 30855528
Article Published Date : Mar 05, 2019
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Melanoma
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Natural compounds against doxorubicin-induced cardiotoxicity.Sep 27, 2020

Pubmed Data : Phytother Res. 2020 Sep 28. Epub 2020 Sep 28. PMID: 32985744
Article Published Date : Sep 27, 2020
Study Type : In Vitro Study
Additional Links
Substances : Alpha Linolenic Acid, Apigenin, Asiatic Acid, Ferulic acid, Genistein, Ginsenosides, Indole-3-Carbinol, Naringenin , P-Coumaric Acid, Punicalagin, Quercetin, Reishi Mushroom, Sulforaphane, Tanshinone IIA
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents, Nrf2 activation
Additional Keywords : Polysaccharides
[+]

P-coumaric acid ameliorates ionizing radiation-induced intestinal injury through modulation of oxidative stress and pyroptosis.Jul 31, 2021

Pubmed Data : Life Sci. 2021 Aug 1 ;278:119546. Epub 2021 Apr 26. PMID: 33915129
Article Published Date : Jul 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Oxidative Stress, Radiation
Pharmacological Actions : Radioprotective
[+]

P-coumaric acid and ursolic acid from Corni fructus attenuated β-amyloid(25-35)-induced toxicity.May 27, 2014

Pubmed Data : J Agric Food Chem. 2014 May 28 ;62(21):4911-6. Epub 2014 May 19. PMID: 24815946
Article Published Date : May 27, 2014
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid, Ursolic Acid
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

p-coumaric acid has a potential therapeutic role in the prevention of cataract.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:8549052. Epub 2018 Apr 10. PMID: 29849919
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Cataract
Pharmacological Actions : Anti-Apoptotic, Antioxidants
[+]

P-coumaric acid inhibits the Listeria monocytogenes RecA protein functions and SOS response: An antimicrobial target.Sep 30, 2019

Pubmed Data : Biochem Biophys Res Commun. 2019 Oct 1 ;517(4):655-661. Epub 2019 Aug 13. PMID: 31416617
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Listeria Infections
Pharmacological Actions : Antimicrobial
[+]

P-coumaric acid may be a promising candidate for the treatment of osteoarthritis.Dec 09, 2019

Pubmed Data : Inflammation. 2019 Dec 10. Epub 2019 Dec 10. PMID: 31823179
Article Published Date : Dec 09, 2019
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

P-coumaric acid mediated protection of H9c2 cells from doxorubicin-induced cardiotoxicity.May 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Jun ;102:823-832. Epub 2018 Apr 5. PMID: 29605770
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Cardioprotective, Chemoprotective Agents
[+]

P-coumaric acid modulates glucose and lipid metabolism via AMP-activated protein kinase in L6 skeletal muscle cells.Mar 21, 2013

Pubmed Data : Biochem Biophys Res Commun. 2013 Mar 22 ;432(4):553-7. Epub 2013 Feb 26. PMID: 23485470
Article Published Date : Mar 21, 2013
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Hyperglycemia, Hyperlipidemia
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic
[+]

p-coumaric acid was effective in production of ROS-dependent mitochondrial damage-induced cytotoxicity in neuroblastoma N2a cells.Jan 31, 2015

Pubmed Data : Mol Neurobiol. 2015 Feb ;51(1):119-30. Epub 2014 Apr 24. PMID: 24760364
Article Published Date : Jan 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Neuroblastoma
Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Polyphenols as inhibitors of antibiotic resistant bacteria-mechanisms underlying rutin interference with bacterial virulence.Mar 20, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2022 Mar 21 ;15(3). Epub 2022 Mar 21. PMID: 35337182
Article Published Date : Mar 20, 2022
Study Type : In Vitro Study
Additional Links
Substances : Chlorogenic Acid, Citrus naringin, Ferulic acid, Gallic Acid, Hesperidin, Naringenin , P-Coumaric Acid, Rutin
Diseases : Pseudomonas aeruginosa
Pharmacological Actions : Anti-Bacterial Agents
[+]

Preventive effects of p-coumaric acid on cardiac hypertrophy and alterations in electrocardiogram, lipids, and lipoproteinsSep 30, 2013

Pubmed Data : Food Chem Toxicol. 2013 Oct ;60:348-54. Epub 2013 May 10. PMID: 23669407
Article Published Date : Sep 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Cardiomegaly, Myocardial Infarction
Pharmacological Actions : Cardioprotective
[+]

Spectroscopic studies on the antioxidant activity of p-coumaric acid.Oct 31, 2013

Pubmed Data : Spectrochim Acta A Mol Biomol Spectrosc. 2013 Nov ;115:719-24. Epub 2013 Jul 8. PMID: 23892112
Article Published Date : Oct 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

The coumaric acid and syringic acid ameliorate acetic acid-induced ulcerative colitis.Jun 30, 2023

Pubmed Data : Int Immunopharmacol. 2023 Jul ;120:110309. Epub 2023 May 12. PMID: 37182450
Article Published Date : Jun 30, 2023
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid, Syringic Acid
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The results suggest that p-coumaric acid might act as quorum sensing inhibitor.Oct 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lett Appl Microbiol. 2009 Nov ;49(5):551-5. Epub 2009 Jul 24. PMID: 19709367
Article Published Date : Oct 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Garlic, P-Coumaric Acid
Diseases : Escherichia coli Infections
Pharmacological Actions : Quorum Sensing Inhibition
Additional Keywords : Plant Extracts
[+]

These results depicted that p-Coumaric acid inhibited the growth of colon cancer cells by inducing apoptosis through ROS-mitochondrial pathway.Nov 20, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2013 Nov 21 ;19(43):7726-34. PMID: 24282361
Article Published Date : Nov 20, 2013
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Colon Cancer, Oxidative Stress
Pharmacological Actions : Antineoplastic Agents, Antioxidants, Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Various polyphenols exhibit potential anti-obesity activity. Jan 26, 2011

Pubmed Data : J Agric Food Chem. 2011 Jan 26;59(2):546-51. Epub 2010 Dec 27. PMID: 21186817
Article Published Date : Jan 26, 2011
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid, Quercetin, Resveratrol
Diseases : Obesity
Pharmacological Actions : Glutathione Upregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor

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